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  • Articles  (671)
  • United States  (490)
  • Kinetics  (182)
  • American Association for the Advancement of Science (AAAS)  (671)
  • Annual Reviews
  • 1980-1984  (515)
  • 1975-1979  (156)
  • 1965-1969
  • 1955-1959
  • 1930-1934
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  • Articles  (671)
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1978 Nov 10;202(4368):603.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705348" target="_blank"〉PubMed〈/a〉
    Keywords: Economics ; *Environmental Health ; Government Agencies ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):191-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694524" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Exposure ; Legislation as Topic ; Mining/*standards ; New Mexico ; United States ; *Uranium ; Utah
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1978-11-03
    Description: Between 1973 and 1977 the total number of Ph.D.'s holding postdoctoral appointments in the biomedical sciences increased at a rate of more than 550 individuals (12.5 percent) per year. During this same period the total number of doctorates awarded each year in these disciplines showed very little change. The postdoctoral growth can be attributed to substantial increases in both the numbers of recent graduates taking postdoctorals and the length of stay on these appointments. The lack of alternative employment opportunities has contributed heavily to the postdoctoral buildup. Continued growth is likely to have important consequences for biomedical research and research training.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coggeshall, P E -- Norvell, J C -- Bogorad, L -- Bock, R M -- New York, N.Y. -- Science. 1978 Nov 3;202(4367):487-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705338" target="_blank"〉PubMed〈/a〉
    Keywords: Biology/*manpower/trends ; Education, Continuing/*trends ; Employment ; *Research Support as Topic ; Salaries and Fringe Benefits ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1978 May 26;200(4344):883-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644330" target="_blank"〉PubMed〈/a〉
    Keywords: Bed Occupancy ; Diagnosis/economics ; Economics, Hospital ; *Economics, Medical ; Education, Medical ; Fees and Charges ; Insurance, Health/economics ; Legislation, Medical ; Medical Laboratory Science/economics ; Therapeutics/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-05-26
    Description: This article classifies the major approaches to the assessment of the process and outcomes of medical care. The apparent need to safeguard and enhance the quality of care has led to the institution of mechanisms that subject care to constant review so that deficiencies may be found and corrected. The article reviews the developments that led to the involvement of the federal government in this activity through its sponsorship of professional standards review organizations (PSRO's). The major features of the PSRO's are described and their possible effects discussed. It is too early to say how the PSRO's will fare, but should they fail to accomplish their objectives the pressure for more radical solutions will be difficult to resist.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donabedian, A -- New York, N.Y. -- Science. 1978 May 26;200(4344):856-64.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417400" target="_blank"〉PubMed〈/a〉
    Keywords: Computers ; Concurrent Review ; Cost-Benefit Analysis ; Humans ; Medical Records/standards ; Methods ; Peer Review ; Physician-Patient Relations ; Professional Review Organizations/economics/legislation & jurisprudence/standards ; *Quality of Health Care ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-09-08
    Description: The reactive superoxide radical, O2-, formerly of concern only to radiation chemists and radiobiologists, is now understood to be a normal product of the biological reduction of molecular oxygen. An unusual family of enzymes, the superoxide dismutases, protect against the deleterious actions of this radical by catalyzing its dismutation to hydrogen peroxide plus oxygen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fridovich, I -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):875-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210504" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Catalase/metabolism ; Free Radicals ; Inflammation/metabolism ; Kinetics ; Metals ; Oxidation-Reduction ; Oxygen/*metabolism ; Paraquat/pharmacology ; Peroxidases/metabolism ; Superoxide Dismutase/*metabolism ; Superoxides/*metabolism/toxicity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graham, L R -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):383-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705332" target="_blank"〉PubMed〈/a〉
    Keywords: *Foreign Professional Personnel ; *International Cooperation ; *Science ; Ussr ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-09-22
    Description: This article reports a study of the activities and performance of institutional review boards to protect human research subjects. Researchers and institutional review board members were generally supportive of the review system, although substantial criticisms were also heard. Institutional review boards had some direct impact on half of the proposals reviewed by requiring either modification of or additional information about proposed research. The data, however, raise questions about the effectiveness of some review board actions, for example, with regard to informed consent. Some policy implications of the study are presented.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, B H -- Cooke, R A -- Tannenbaum, A S -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1094-101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/356268" target="_blank"〉PubMed〈/a〉
    Keywords: Attitude ; Behavioral Research ; Bioethics ; Clinical Trials as Topic ; Consent Forms ; *Ethical Review ; *Ethics Committees, Research ; *Human Experimentation ; Humans ; Informed Consent ; *Research/standards ; Risk ; Risk Assessment ; United States ; United States Dept. of Health and Human Services
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 1978-07-07
    Description: The density but not the affinity of beta-adrenergic receptors declined significantly with age in rat pineal gland, corpus striatum, and cerebellum, as determined by the binding of tritiated dihydroalprenolol. Exposing rats to light for 12 hours increased the binding of this radioligand in 3-month-old but not in 24-month-old rats. The reduced responsiveness to catecholamines seen in aging may be due to a decrease in the number of beta-adrenergic receptors which, in turn, may be caused by an impaired capacity of receptors in aged animals to adapt to changes in adrenergic neuronal input.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenberg, L H -- Weiss, B -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):61-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208145" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Alprenolol/analogs & derivatives/metabolism ; Animals ; Brain/*metabolism ; Cerebellum/metabolism ; Circadian Rhythm ; Corpus Striatum/metabolism ; Kinetics ; Light ; Male ; Neuroglia/metabolism ; Pineal Gland/*metabolism ; Rats ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 1978-11-17
    Description: When adenosine deaminase activity is inhibited, low concentrations of adenosine are toxic to human lymphoblast mutants that are unable to convert adenosine to intracellular nucleotides. In order to identify the mediator of this cytotoxicity, we searched for a cytoplasmic protein capable of binding adenosine with high affinity. Such a protein was identified in extracts of human lymphoblasts and placenta as the enzyme S-adenosylhomocysteine hydrolase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hershfield, M S -- Krodich, N M -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):757-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715439" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*metabolism ; Adenosine Deaminase/*deficiency ; Carrier Proteins/*metabolism ; Female ; Humans ; Hydrolases/*metabolism ; Kinetics ; Lymphocytes/metabolism ; Nucleoside Deaminases/*deficiency ; Placenta/metabolism ; Pregnancy ; S-Adenosylhomocysteine/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):196.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694525" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdalin/*therapeutic use ; Federal Government ; Humans ; National Institutes of Health (U.S.) ; Neoplasms/*drug therapy ; Research Support as Topic ; United States
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  • 12
    Publication Date: 1978-10-13
    Description: Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after intravenous administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Javaid, J I -- Fischman, M W -- Schuster, C R -- Dekirmenjian, H -- Davis, J M -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):227-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694530" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intranasal ; Cocaine/administration & dosage/*blood/*pharmacology ; Dose-Response Relationship, Drug ; Euphoria/*drug effects ; Heart Rate/drug effects ; Humans ; Injections, Intravenous ; Kinetics ; Metabolic Clearance Rate
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-05-26
    Description: Long-term care for the aged in the United States is overly dependent upon the nursing home. This hospital-like model for long-term care is particularly inappropriate since it imposes a medical solution on a variety of social problems. An adequate long-term care program requires a range of resources in the community as well as in institutions; sheltered housing options seem a desirable alternative to the nursing home. To ensure the quality of nursing home care, the present focus on setting standards for care activities should be abandoned in favor of a focus on care outcomes (physical, mental, and social). In an effort to change our present perverse incentives in the nursing home industry, the proposal is made that nursing homes be reimbursed according to the degree to which patient outcomes meet predicted outcomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kane, R L -- Kane, R A -- New York, N.Y. -- Science. 1978 May 26;200(4344):913-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417403" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Financing, Government ; Health Facilities, Proprietary ; *Homes for the Aged/economics ; Humans ; Long-Term Care/*methods ; *Nursing Homes/economics/standards ; Socioeconomic Factors ; United States
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-01-27
    Description: A stopped-flow circular dichroism instrument, with a total accessible wavelength range of 200 to 750 nanometers, has been constructed and provides a spectroscopic method for kinetic investigations of a wide array of fast reactions in which optical activity changes in absorbing regions are involved. An important biochemical application depends on the far-ultraviolet capability, which allows observation of the rapid alterations in backbone conformation associated with folding and unfolding reactions of proteins. Results obtained by following two such reactions at 222 nanometers represent direct monitoring by circular dichroism of rapid secondary structure changes in proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luchins, J -- Beychok, S -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):425-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619462" target="_blank"〉PubMed〈/a〉
    Keywords: *Circular Dichroism ; Hemoglobins ; Kinetics ; Methemoglobin ; *Protein Conformation ; Protein Denaturation ; Spectrophotometry, Ultraviolet/methods ; *Spectrum Analysis
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1265-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725600" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Recombinant/*standards ; Environment ; Environmental Pollution/prevention & control ; Government Regulation ; Legislation as Topic ; Research Design/*standards ; Risk Assessment ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):949-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715452" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants/toxicity ; Dose-Response Relationship, Drug ; Environmental Exposure ; Government Agencies ; Humans ; Industry ; Ozone/toxicity ; United States
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-09-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):795-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684406" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.) ; Nicotine/toxicity ; Smoking/*complications ; Tars/toxicity ; United States ; United States Dept. of Health and Human Services
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  • 18
    Publication Date: 1978-09-01
    Description: Hepatic pigment clearance in rats can be followed continuously with photometric detectors designed for high-pressure liquid chromatography. This method showed that light has a fast effect on bilirubin metabolism in homozygous Gunn rats, even at low doses and intensities. This is consistent with geometric isomerization of bilirubin IXalpha as a primary step in phototherapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McDonagh, A F -- Ramonas, L M -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):829-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/581101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bile/metabolism ; Bilirubin/blood/*metabolism/radiation effects ; *Disease Models, Animal ; Humans ; Infant, Newborn ; Jaundice, Neonatal/*therapy ; Kinetics ; Liver/metabolism ; *Phototherapy ; Rats
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-03-10
    Description: Incubation of ribonuclease with 0.1M mercaptoethanol at pH 8.5 can increase the enzyme's hydrolytic activity toward cytidine 2',3'-monophosphate (cyclic CMP) under standard assay conditions. Cation-exchange chromatography of the ribonuclease-thiol reaction mixture revealed seven fractions. The fraction with the highest activity had an approximate tenfold decrease in the apparent Michaelis constant for cyclic CMP with respect to native ribonuclease. The enhanced activity is a metastable property since this fraction reverts back to the control activity and chromatographic behavior of native ribonuclease on standing in solution at room temperature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watkins, J B -- Benz, F W -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1084-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/564548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Disulfides/pharmacology ; Enzyme Activation/drug effects ; Glutathione/pharmacology ; Kinetics ; Mercaptoethanol/*pharmacology ; Oxidation-Reduction ; Pancreas/enzymology ; Protein Conformation ; Ribonucleases/*metabolism ; Structure-Activity Relationship
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1978 May 26;200(4344):886-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347578" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Medical ; *Financing, Government ; Health Services/*economics ; Legislation, Medical ; Medicaid/economics ; Medicare/economics ; Professional Review Organizations/economics ; Research Support as Topic ; Training Support ; United States
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-08-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):600-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/353985" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Recombinant/*standards ; DNA, Viral/genetics ; Escherichia coli/genetics/pathogenicity ; *Federal Government ; *Government Regulation ; National Institutes of Health (U.S.) ; Research Design/standards ; Risk Assessment ; United States ; United States Dept. of Health and Human Services
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208151" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Warfare ; Centers for Disease Control and Prevention (U.S.) ; *Smallpox/prevention & control ; United States ; Variola virus ; Virus Cultivation ; *World Health Organization
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):952-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/341315" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; *Delivery of Health Care ; *Public Policy ; United States ; *United States Department of Veterans Affairs
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-05-26
    Description: Defensive medicine--the use of diagnostic and end-treatment measures explicitly for the purposes of averting malpractice suits--is frequently cited as one of the least desirable effects of the current rise in medical litigation. Many physicians and policy-makers claim that defensive medicine is responsible not only for the increasing costs of health care but the exposing of patients to significant risks of harm from unnecessary procedures. Very little solid information is available about defensive medicine. The studies that have been conducted have been fraught with statistical difficulties and are by no means definitive. Even more important than the issue of defensive medicine is the more basic problem of our system of compensation for medical injuries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tancredi, L R -- Barondess, J A -- New York, N.Y. -- Science. 1978 May 26;200(4344):879-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644329" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cesarean Section/utilization ; Child ; Costs and Cost Analysis ; Craniocerebral Trauma/radiography ; *Defensive Medicine/economics ; Female ; Fetal Monitoring/utilization ; Humans ; *Malpractice/economics ; Physician-Patient Relations ; Pregnancy ; Quality of Health Care ; Surveys and Questionnaires ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):666-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493971" target="_blank"〉PubMed〈/a〉
    Keywords: Diet/*adverse effects ; Disease/*etiology ; Humans ; Legislation as Topic ; National Institutes of Health (U.S.) ; Nutritional Physiological Phenomena ; Peer Review ; Preventive Medicine/methods ; Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1175-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451563" target="_blank"〉PubMed〈/a〉
    Keywords: Diabetes Mellitus/etiology ; Diet/*adverse effects ; Disease/*etiology ; *National Institutes of Health (U.S.) ; Neoplasms/etiology ; *Nutritional Physiological Phenomena ; Preventive Medicine ; United States
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1164, 1166.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504999" target="_blank"〉PubMed〈/a〉
    Keywords: *Chemical Warfare Agents ; Containment of Biohazards ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1324-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/106470" target="_blank"〉PubMed〈/a〉
    Keywords: Benzene/*toxicity ; *Carcinogens ; Cost-Benefit Analysis ; Environmental Exposure ; Government Agencies ; Legislation, Drug ; Risk ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):540-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493959" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic/standards ; Analgesics/*standards ; Aspirin/*standards ; Drug Industry/*standards ; Jurisprudence ; Nonprescription Drugs/*standards ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Handler, P -- New York, N.Y. -- Science. 1979 May 4;204(4392):474-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432651" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/history ; Biology/history ; Chemistry/history ; Environment ; Government Agencies/history ; History, 20th Century ; Physics/history ; *Research Support as Topic ; Science/*history ; Social Sciences/history ; United States ; Universities/history/manpower
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hiatt, H H -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1361.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505011" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Health ; Research ; United States
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  • 32
    Publication Date: 1979-09-14
    Description: Binding sites for tritum-labeled gamma-aminobutyric acid (GABA) in cerebellar cortex of Huntington's chorea patients have an increased affinity but unaltered maximum capacity as compared to binding sites in tissue from control patients. A similar binding pattern is produced in control membranes by treatment with Triton X-100, phospholipase C, or glycerophosphoethanolamine. Thus, it is likely that phospholipids or their metabolites regulate the accessibility of the GABA binding site and that this regulation is abnormal in Huntington's chorea.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lloyd, K G -- Davidson, L -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1147-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224459" target="_blank"〉PubMed〈/a〉
    Keywords: Cerebellar Cortex/*metabolism ; Humans ; Huntington Disease/*metabolism ; Kinetics ; Membrane Lipids ; Phosphatidylethanolamines/physiology ; Polyethylene Glycols/pharmacology ; Receptors, Neurotransmitter/drug effects/*metabolism ; gamma-Aminobutyric Acid/*metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knapka, J J -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1367.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/582217" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed/*analysis ; Animals ; Animals, Laboratory ; Hot Temperature ; National Institutes of Health (U.S.) ; Nitrosamines/analysis ; United States
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  • 34
    Publication Date: 1979-05-25
    Description: Single islet cells in monolayer cultures of neonatal rat pancreas were microinjected with fluorescein and scanned topographically by microfluorometry. Fluorescein spread from an injected islet cell directly into neighboring islet cells, and, in the presence of 16.7 millimolar glucose, significantly more islet cells communicated with the injected cell than in glucose-free medium. Islet cells were also microinjected with glycolytic substrates and activators that produced transient changes in cellular levels of reduced pyridine nucleotides-nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate [NAD(P)H]. Changes in NAD(P)H fluorescence were observed in islet cells incubated first for 18 hours in very low glucose concentrations and then in a glucose-free medium and injected with glycolytic substrates and activators; however, little change of fluorescence occurred in adjacent islet cells. In contrast, after adding 16.7 millimolar glucose to the medium, injection of glycolytic substrates and activators produced transient changes in NAD(P)H fluorescence in the injected cell and in neighboring cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kohen, E -- Kohen, C -- Thorell, B -- Mintz, D H -- Rabinovitch, A -- New York, N.Y. -- Science. 1979 May 25;204(4395):862-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/35828" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Communication/drug effects ; Fluoresceins ; Glucose/pharmacology ; Glycolysis ; Islets of Langerhans/cytology/*physiology ; Kinetics ; NAD/metabolism ; NADP/metabolism ; Rats ; Spectrometry, Fluorescence
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1054-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493991" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Drug Industry/*economics ; Legislation, Drug ; *Therapeutic Equivalency ; United States ; United States Food and Drug Administration
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1094-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424735" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Lactates/blood ; Legislation, Drug ; Phenformin/adverse effects/*standards ; United States ; United States Dept. of Health and Human Services ; United States Food and Drug Administration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):774-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/379998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; France ; History, 20th Century ; Humans ; Mice ; Psychotropic Drugs/*history/metabolism/therapeutic use ; Rats ; Schizophrenia/drug therapy ; United States
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):986-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/370980" target="_blank"〉PubMed〈/a〉
    Keywords: Cardiovascular Diseases/chemically induced ; Clinical Trials as Topic ; Diabetes Mellitus/*drug therapy ; Drug Information Services ; History, 20th Century ; Humans ; Hypoglycemic Agents/adverse effects/history/*standards ; Jurisprudence ; Legislation, Drug/*history ; Phenformin/adverse effects ; Research Design/standards ; Tolbutamide/adverse effects ; United States ; United States Food and Drug Administration/history
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1058-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/386515" target="_blank"〉PubMed〈/a〉
    Keywords: Amantadine/history/*therapeutic use ; History, 20th Century ; Humans ; Influenza A virus ; Influenza, Human/prevention & control/*therapy ; National Institutes of Health (U.S.) ; United States
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-11-30
    Description: The tertiary structures of all liganded hemoglobins in the R state differ in detail. Steric hindrance arising from nonbonded ligand-globin interactions affects the binding of ligands such as CO and cyanide which preferentially form linear axial complexes to heme; these ligands bind in a strained off-axis configuration. Ligands such as O2 and NO, which preferentially form bent complexes, encounter less steric hindrance and can bind in their (preferred) unstrained configuration. Linear complexes distort the ligand pockets in the R state (and by inference, in the T state) more than bent complexes. These structural differences between linear and bent complexes are reflected in the kinetic behavior of hemoglobin. Structural interpretation of this kinetic behavior indicates that the relative contributions of nonbonded ligand-globin interactions and nonbonded heme interactions to transition state free energies differ for linear and bent ligands. The relative contributions of these interactions to the free energy of cooperativity may also differ for linear and bent ligands. Thus the detailed molecular mechanism by which the affinity of heme is regulated differs for different ligands.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moffat, K -- Deatherage, J F -- Seybert, D W -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1035-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493990" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Animals ; Heme/*metabolism ; Hemoglobins/metabolism ; Horses ; Kinetics ; Ligands ; Oxygen/*metabolism ; Oxyhemoglobins/*metabolism ; Protein Conformation ; Stereoisomerism ; Structure-Activity Relationship
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-05-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1979 May 18;204(4394):711, 713-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441736" target="_blank"〉PubMed〈/a〉
    Keywords: Congenital Abnormalities/etiology ; Dose-Response Relationship, Radiation ; Humans ; Maximum Allowable Concentration ; Neoplasms, Radiation-Induced/etiology ; Radiation Injuries/*etiology ; Risk ; Societies, Scientific ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-01-05
    Description: An adenylate cyclase activated as much as 25-fold by low concentrations of octopamine has been identified in the firefly lantern. The relative potency of octopamine and various other amines in stimulating this enzyme, and effects of antagonists in blocking octopamine activation, correlate well with the known effects of these agents in affecting light production. In addition to suggesting a role for adenosine 3',5'-monophosphate (or pyrophosphate) in the neural control of firefly flashing, identification of this potent enzyme should facilitate the characterization of phenylethylamine receptors in excitable tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathanson, J A -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):65-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214856" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Beetles/*physiology ; Catecholamines/pharmacology ; Cyclic AMP/*biosynthesis ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Kinetics ; Octopamine/*pharmacology ; Phentolamine/pharmacology ; Propranolol/pharmacology ; Receptors, Cell Surface/*drug effects ; Receptors, Neurotransmitter/*drug effects ; Structure-Activity Relationship
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-10
    Description: A competitive inhibitor of colchicine binding to tubulin has been found in rat brain. Most of the inhibitor is associated with microsomes but some inhibitor, with an apparent molecular weight of approximately 250,000, is found in the cytosol. Both the microsomal and cytosol inhibitors are heat- and trypsin-sensitive, indicating that a protein moiety is required for activity. The microsomes bind tubulin directly; the microsomal and cytosol fractions both inhibit microtubule assembly in vitro. The inhibitor may function in the living cell to bind and sequester non-polymerized tubulin. Regulation of tubulin attachment to microsomes could then control the concentration of cytosolic tubulin available for microtubule assembly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sherline, P -- Schiavone, K -- Brocato, S -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):593-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451622" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Colchicine/*metabolism ; Cytosol/physiology ; Glycoproteins/*metabolism ; Kinetics ; Microsomes/metabolism ; Microtubules/ultrastructure ; Nerve Tissue Proteins/*physiology ; Protein Binding/drug effects ; Rats ; Tubulin/*metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shubik, P -- Clayson, D B -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):746, 748.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462187" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; *Drug Evaluation, Preclinical ; *National Institutes of Health (U.S.) ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1287-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay/methods ; *Carcinogens ; Legislation as Topic ; Mice ; *National Institutes of Health (U.S.) ; Research Design/standards ; Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-06-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pings, C J -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1158.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451562" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; *Research Support as Topic ; United States
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  • 47
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-08-17
    Description: Platelet lysates obtained from blood of humans, dogs, and rats catalyzed the transamination of 4-aminobutyrate with 2-oxoglutarate as cosubstrate. Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet protein) resembled the brain enzyme in kinetic properties and in response to cofactors and inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, H L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):696-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462176" target="_blank"〉PubMed〈/a〉
    Keywords: 4-Aminobutyrate Transaminase/*blood ; Animals ; Blood Platelets/*enzymology ; Brain/enzymology ; Dogs ; Enzyme Activation/drug effects ; Humans ; Kinetics ; Pyridoxal Phosphate/pharmacology ; Rats ; Substrate Specificity ; Transaminases/*blood ; gamma-Aminobutyric Acid/blood
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1980 Sep 26;209(4464):1497-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433971" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Legislation as Topic ; *National Institutes of Health (U.S.) ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-04-04
    Description: The rapid advances in computer and communication technology in the 1970's have enabled large interactive scientific and technical information retrieval systems to be implemented. Major search services today offer on-line access to millions of bibliographic citations and an increasing number of "electronic handbooks." In addition, development of knowledge bases is well under way. Despite the impressive speed and flexibility of interactive retrieval systems, their impact has been lessened by limited awareness of their existence, uneven quality of retrieval, inadequate linkages among data bases, and reliance on specially trained intermediaries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doszkocs, T E -- Rapp, B A -- Schoolman, H M -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):25-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6987735" target="_blank"〉PubMed〈/a〉
    Keywords: *Computers ; History, 20th Century ; *Information Systems ; MEDLARS/history ; *National Library of Medicine (U.S.) ; *Science ; *Technology ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eisenbud, M -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1299.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355289" target="_blank"〉PubMed〈/a〉
    Keywords: Hospitals ; Laboratories ; Medical Waste ; *Radioactive Waste ; United States
    Print ISSN: 0036-8075
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  • 51
    Publication Date: 1980-03-28
    Description: When microbial strains compete for the same limiting nutrient in continuous culture, resource-based competition theory predicts that only one strain will survive and all others will die out. The surviving strain expected from theory will be the one with the smallest subsistence or "break-even" concentration of the limiting resource, a concentration defined by the J parameter. This prediction has been confirmed in the case of auxotrophic bacterial strains competing for limiting tryptophan. Because the value of J can be measured on the strains grown alone, the theory can predict the qualitative outcomes of mixed-growth competition in advance of actual competition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansen, S R -- Hubbell, S P -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6767274" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteria/*growth & development ; Culture Media ; Drug Resistance, Microbial ; Escherichia coli/growth & development ; Kinetics ; Models, Theoretical ; Nalidixic Acid/pharmacology ; Nutritional Physiological Phenomena ; Pseudomonas aeruginosa/growth & development ; Tryptophan/metabolism
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):160-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985747" target="_blank"〉PubMed〈/a〉
    Keywords: Hospices/*economics ; Humans ; Insurance, Health ; Medicaid ; Medicare ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-11-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marston, R Q -- New York, N.Y. -- Science. 1980 Nov 14;210(4471):721.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433994" target="_blank"〉PubMed〈/a〉
    Keywords: Legislation as Topic ; *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knox, R A -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):570-2, 574-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6994226" target="_blank"〉PubMed〈/a〉
    Keywords: Boston ; Cardiac Surgical Procedures/*economics ; *Federal Government ; Government Agencies ; Government Regulation ; *Heart Transplantation ; Hospitals, General ; Humans ; *Patient Selection ; *Resource Allocation ; Transplantation, Homologous ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-10-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):518-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423201" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*etiology ; Dicyclomine ; Doxylamine/*adverse effects ; Drug Combinations/adverse effects ; Drug Evaluation ; Female ; Humans ; Jurisprudence ; Pregnancy ; Pyridines/*adverse effects ; Pyridoxine/*adverse effects ; United States ; United States Food and Drug Administration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6157193" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Therapeutic/standards ; Female ; Genetic Diseases, Inborn ; Government Regulation ; Great Britain ; Humans ; Neural Tube Defects/*diagnosis ; Pregnancy ; *Pregnant Women ; *Prenatal Diagnosis ; Reagent Kits, Diagnostic ; Social Justice ; Spina Bifida Occulta/diagnosis ; United States ; Voluntary Programs ; alpha-Fetoproteins/analysis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 May 2;208(4443):473-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6988966" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; Humans ; *Medicare ; Quality of Health Care ; Renal Dialysis/economics/rehabilitation/*trends ; Resource Allocation ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-07-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):475-6, 478-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394512" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anorexia Nervosa ; Female ; *Human Experimentation ; Humans ; *Jurisprudence ; Lithium ; *National Institutes of Health (U.S.) ; *Patient Selection ; *Research ; *Research Subjects ; Sleep ; United States ; Vomiting
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Jun 13;208(4449):1239-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375934" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Aberrations ; Chromosomes/*drug effects ; Drug Industry ; Government Agencies ; Humans ; New York ; Research Design ; Soil Pollutants/*adverse effects ; United States ; Water Pollutants/*adverse effects ; Water Pollutants, Chemical/*adverse effects
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mac Lane, S -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):158-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7414327" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Consultants ; *Government Agencies ; *Research Support as Topic/economics ; Salaries and Fringe Benefits ; United States ; Universities
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1228-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434021" target="_blank"〉PubMed〈/a〉
    Keywords: *Radioactive Waste/economics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-07-11
    Description: The appropriate technology for control of diseases of economically underdeveloped countries happens to be mainly that applicable to groups as a whole; whereas that effective for most diseases of industrialized societies must be individually delivered. The latter area is where the pharmaceutical industry has scored its greatest triumphs, yet most of this technology does not fit the major disease problems as they now exist in the developing countries. The argument is presented that in order for the U.S. industry to do more in the developing countries, the most needed invention is not a new drug, but a new system for drug development--a new R & D system tailored specially to both the financial and the biologic needs of the problem.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McDermott, W -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):240-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384797" target="_blank"〉PubMed〈/a〉
    Keywords: *Delivery of Health Care ; *Developing Countries ; Humans ; Infant Mortality ; Infant, Newborn ; *Public Health ; Research ; *Technology, Pharmaceutical ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-02-15
    Description: Autoradiographic and biochemical analyses of the hearts of female rhesus monkeys and baboons indicate that atrial and ventricular myocardial cells contain androgen receptors. Although the specific effects of nuclear uptake and retention of androgen on the function of heart muscle cells are not known, the presence of this receptor suggests that sex steroid hormones may affect myocardial function directly and may explain some of the peculiar differences in heart disease between men and women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGill, H C Jr -- Anselmo, V C -- Buchanan, J M -- Sheridan, P J -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6766222" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/*metabolism ; Animals ; Coronary Disease/*etiology ; Dihydrotestosterone/metabolism ; Estradiol/metabolism ; Female ; Haplorhini ; Kinetics ; Macaca mulatta ; Myocardium/*metabolism ; Papio ; Receptors, Androgen/*metabolism ; Receptors, Steroid/*metabolism ; Sex Factors
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  • 64
    Publication Date: 1980-07-25
    Description: Accurate measurements of intracellular calcium activities in salivary gland epithelial cells of the insect Phormia regina were obtained with microelectrodes in which N,N'-di(11-ethoxycarbonyl)undecyl-N,N'-4,5-tetramethyl-3,6-dioxaoctane diacid diamide wsa incorporated in a liquid membrane system. When calibrated in solutions approximating the ionic concentration of the cell interior, these microelectrodes gave rapid stable responses that were linear functions of the logarithm of calcium activities and were not affected by potassium, sodium and magnesium. Continuous monitoring of calcium activities during serotonin-induced saliva release provided direct evidence of hormonal influence on transmembrane calcium movement and spontaneous regulation of intracellular calcium by stimulated cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Doherty, J -- Youmans, S J -- Armstrong, W M -- Stark, R J -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):510-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394518" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Diptera/*metabolism ; Epithelium/metabolism ; Kinetics ; Magnesium/pharmacology ; Microelectrodes ; Salivary Glands/drug effects/*metabolism ; Serotonin/pharmacology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oettinger, A G -- New York, N.Y. -- Science. 1980 Jul 4;209(4452):191-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280661" target="_blank"〉PubMed〈/a〉
    Keywords: *Information Services/trends ; Jurisprudence ; United States ; Warfare
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parloff, M B -- New York, N.Y. -- Science. 1980 Feb 22;207(4433):823.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7356844" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; Humans ; Psychotherapy/*standards ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-11-21
    Description: The rate at which glucose enters nerve terminals in muscle was estimated indirectly by measuring changes in miniature end-plate potential frequency D-Glucose entered nerve terminals in muscles with a fast twitch more rapidly than it entered those with a slow twitch. This suggests that nerve terminals in fast- and slow-twitch muscles differ in their rate of metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickett, J B -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):927-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434009" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; Diaphragm/innervation ; Glucose/*metabolism ; Kinetics ; Membrane Potentials ; Nerve Endings/*metabolism ; Neuromuscular Junction/*metabolism ; Osmolar Concentration ; Rats
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-01-25
    Description: Carter Administration actions to enhance basic research and stimulate industrial innovation have focused attention on the importance of formal university-industry cooperative relationships in science and engineering. We have examined the status of, and potential for, university-industry research consortia and research partnerships and the current and prospective roles of the federal government in stimulating such relationships.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prager, D J -- Omenn, G S -- New York, N.Y. -- Science. 1980 Jan 25;207(4429):379-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350670" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Economics ; Government Agencies ; *Industry ; Patents as Topic ; *Research ; Research Support as Topic ; Taxes ; United States ; *Universities
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-05-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1980 May 9;208(4444):581.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367880" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Industry/*standards ; *Environmental Exposure ; Government Agencies ; Humans ; United States ; *Waste Products
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-03-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1188.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355280" target="_blank"〉PubMed〈/a〉
    Keywords: Economics ; Government Agencies ; *Industrial Waste ; United States ; *Water Pollutants/analysis ; *Water Pollutants, Chemical/analysis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-03-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1189-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355281" target="_blank"〉PubMed〈/a〉
    Keywords: *Aircraft ; Government Agencies ; Humans ; Legislation as Topic ; *Noise/economics ; *Noise, Transportation/economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-02-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1980 Feb 29;207(4434):963.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352300" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Pollutants ; *Government Agencies ; Jurisprudence ; Legislation as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):567-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394522" target="_blank"〉PubMed〈/a〉
    Keywords: Benzene ; *Carcinogens ; *Government Agencies ; Humans ; Legislation as Topic ; *Occupational Medicine ; Safety ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stumpf, W E -- New York, N.Y. -- Science. 1980 Feb 22;207(4433):822-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355264" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; Peer Review/*methods ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):618.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159683" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Drug Industry ; Fibroblasts/metabolism ; Humans ; Interferons/*biosynthesis ; Male ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):616-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7001624" target="_blank"〉PubMed〈/a〉
    Keywords: *Health Policy ; History, 20th Century ; *Societies, Medical ; United States
    Print ISSN: 0036-8075
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-12-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1105-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444437" target="_blank"〉PubMed〈/a〉
    Keywords: Education ; Engineering/economics ; *Government Agencies/organization & administration ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1980 Jul 4;209(4452):52-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7025203" target="_blank"〉PubMed〈/a〉
    Keywords: History of Medicine ; Periodicals as Topic/*history ; Publishing/history ; Societies, Scientific/*history ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):252-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6104358" target="_blank"〉PubMed〈/a〉
    Keywords: Congresses as Topic ; *Research Support as Topic ; Societies, Scientific ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weneser, J -- New York, N.Y. -- Science. 1980 Feb 22;207(4433):861-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6986649" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; History, 20th Century ; Physics/history ; Societies, Scientific/*history ; United States
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  • 81
    Publication Date: 1980-08-22
    Description: The binding of [6-alanine]gonadotropin-releasing hormone to pituitary plasma membranes increased threefold between metestrus and early proestrus in female rats. Receptor numbers fell rapidly on the afternoon of proestrus coincident with the preovulatory gonadotropin surge. The numbers of receptors for gonadotropin-releasing hormone were positively correlated with concentrations of estradiol in serum; this pattern may be a necessary component of increased pituitary sensitivty to gonadotropin-releasing hormone observed during proestrus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savoy-Moore, R T -- Schwartz, N B -- Duncan, J A -- Marshall, J C -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):942-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/metabolism ; Estradiol/blood ; *Estrus ; Feedback ; Female ; Follicle Stimulating Hormone/blood ; Gonadotropin-Releasing Hormone/analogs & derivatives/*metabolism ; Kinetics ; Luteinizing Hormone/blood ; Pituitary Gland, Anterior/*metabolism ; Pregnancy ; Progesterone/blood ; Rats ; Receptors, Cell Surface/*metabolism
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  • 82
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wharton, C R Jr -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1415.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384783" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; *Food Supply ; Humans ; *Starvation ; United Nations ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolfle, D -- New York, N.Y. -- Science. 1980 Jul 4;209(4452):57-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7025204" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; Periodicals as Topic/economics/*history ; Societies, Scientific/*history ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-05-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Branscomb, L M -- New York, N.Y. -- Science. 1981 May 1;212(4494):514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209546" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior ; Budgets ; Cognition ; Economics ; Engineering/economics ; Forecasting ; *Government Agencies ; Research Support as Topic/*economics ; Social Sciences/economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1981 Apr 10;212(4491):137-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209527" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; *Fraud ; National Institutes of Health (U.S.) ; *Research ; Social Control, Formal ; United States
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1981 Jul 3;213(4503):117.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244625" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; National Institutes of Health (U.S.)/*organization & administration ; *Neoplasms ; *Research ; United States
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  • 87
    Publication Date: 1981-07-31
    Description: Benzodiazepines inhibit Ca2+-calmodulin-stimulated membrane protein phosphorylation. The effects of the benzodiazepines on protein phosphorylation are stereospecific and produced by membrane-bound benzodiazepine. The potency of benzodiazepine kinase inhibition is correlated with the ability of the benzodiazepines to inhibit electric shock-induced convulsions. These findings provide evidence that some of the anticonvulsant and neuronal stabilizing effects of benzodiazepines may be modulated by the Ca2+-calmodulin protein kinase system and indicate that this calmodulin-kinase system represents an identifiable benzodiazepine receptor in brain that is distinquishable by several criteria from the previously described high affinity benzodiazepine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeLorenzo, R J -- Burdette, S -- Holderness, J -- NS 1352/NS/NINDS NIH HHS/ -- NSI-EA-1-K04-NS245/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):546-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/metabolism ; Brain/*enzymology ; Calcium/*pharmacology ; Calcium-Binding Proteins/*pharmacology ; Calmodulin/*pharmacology ; Cell Membrane/enzymology ; Chlordiazepoxide/*pharmacology ; Diazepam/*pharmacology ; Enzyme Activation ; Kinetics ; Molecular Weight ; Phosphorylation ; Protein Kinases/*metabolism ; Rats ; Receptors, Drug/metabolism ; Receptors, GABA-A
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-09-04
    Description: The university system in Canada, as well as its method of funding, was built on the expectation of growth. It is now necessary to consider what effect the expected decline in enrollment may have on the ability of the university system to serve national needs. Neither the government nor the universities have had any experience that would fit them for carrying out effectively, humanly, and economically the kind of contraction that may be required, while still maintaining the quality of education. Such an adjustment is going to require the best efforts of the universities and the two senior levels of government working in concert, as well as the support of the public. Parallels are drawn with the situation in the United States.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fortier, C -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1065-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268413" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; *Science ; United States ; Universities/manpower/*trends
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evans, C H -- Tew, W P -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):653-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256262" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Cations ; *Erbium ; Kinetics ; *Magnetics
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  • 90
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gonzalez, M F -- Deutsch, J A -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1283-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Feeding Behavior ; Kinetics ; Male ; Rats ; *Satiation ; *Satiety Response ; Stomach/*physiology ; *Vagotomy
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  • 91
    Publication Date: 1981-12-04
    Description: The persistence of synthetic herbicides such as 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and its release in massive amounts as a herbicide (Agent Orange) have created toxicological problems in many countries. In nature, 2,4,5-T is slowly degraded by cooxidation and is not utilized as a sole source of carbon and energy. The technique of plasmid-assisted molecular breeding has led to the development of bacterial strains capable of totally degrading 2,4,5-T by using it as their sole source of carbon at high concentrations (greater than 1 mg/ml). Spectrophotometry and gas chromatography reveal various intermediates during growth of the culture with 2,4,5-T.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kellogg, S T -- Chatterjee, D K -- Chakrabarty, A M -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1133-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302584" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/*metabolism ; Bacteria/*genetics/metabolism ; Biotransformation ; Cell Division ; Kinetics ; Nucleic Acid Hybridization ; *Plasmids
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1125-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015508" target="_blank"〉PubMed〈/a〉
    Keywords: Industry ; *Information Services ; *Medlars ; *National Library of Medicine (U.S.) ; United States
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  • 93
    Publication Date: 1981-06-05
    Description: Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations. Both agents inhibited DNA synthesis at concentrations that stimulated resorption. These results might explain the differences in ionophore effects on bone previously reported, and they imply that cell replication is not required for osteoclast formation in fetal rat long bone cultures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorenzo, J A -- Raisz, L G -- AM 07290/AM/NIADDK NIH HHS/ -- AM 18063/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1157-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785885" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/*pharmacology ; Bone Resorption/*drug effects ; Bone and Bones/drug effects/*metabolism ; Calcimycin/*pharmacology ; Calcium/metabolism ; Calcium Radioisotopes ; Cells, Cultured ; DNA/*biosynthesis ; DNA Replication/*drug effects ; Ethers/pharmacology ; Fetus ; Ionomycin ; Ionophores/pharmacology ; Kinetics ; Mice ; Parathyroid Hormone/pharmacology
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  • 94
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-07-31
    Description: A loss in the number of functional, sodium ion-dependent, high-affinity choline transport sites was observed in the cortex and hippocampus of mice given an intracerebroventricular injection of 65 nanomoles of AF64A (ethylcholine mustard aziridinium ion) 3 days earlier. Such an effect was not observed in the striatum. This effect of AF64A represents a long-term neurochemical deficit at cholinergic nerve terminals in some brain regions which can lead to a persistent deficiency in central cholinergic transmission. The AF64A-treated animal may thus be a model for certain psychiatric or neurological disorders that appear to involve central cholinergic hypofunction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mantione, C R -- Fisher, A -- Hanin, I -- MH 26320/MH/NIMH NIH HHS/ -- MH/AG 34893/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):579-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6894649" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aziridines/*pharmacology ; Azirines/*pharmacology ; Biological Transport/drug effects ; Brain/drug effects/*metabolism ; Cerebral Cortex/metabolism ; Choline/*analogs & derivatives/*metabolism/pharmacology ; Corpus Striatum/metabolism ; Hippocampus/metabolism ; Kinetics ; Mice ; Sodium/pharmacology ; Synaptosomes/drug effects/*metabolism
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1120-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7248044" target="_blank"〉PubMed〈/a〉
    Keywords: *Data Display ; Humans ; Radiation Injuries/*etiology ; Risk ; United States ; United States Food and Drug Administration
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-12-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1225-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302591" target="_blank"〉PubMed〈/a〉
    Keywords: *Cephalosporins/therapeutic use ; Humans ; Research ; Structure-Activity Relationship ; United States
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1113.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302582" target="_blank"〉PubMed〈/a〉
    Keywords: Hepatitis B/*prevention & control ; Hepatitis B Surface Antigens/*standards ; Humans ; United States ; United States Food and Drug Administration ; *Vaccines
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  • 98
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rubin, V C -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):915-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008193" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/history ; History, 20th Century ; Societies, Scientific/*history ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmitt, H -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):226.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444463" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-07-31
    Description: During normal development of the hamster eye, there is a substantial loss of cells from the retinal ganglion cell layer in the first two postnatal weeks. If one eye is lost at birth, this cell death is reduced in the remaining eye. This may account for the increased ipsilateral projection from this eye to the thalamus and midbrain observed in these animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sengelaub, D R -- Finlay, B L -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):573-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244655" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Cell Survival ; Cricetinae ; Kinetics ; Neurons/*physiology ; Rats ; Retina/cytology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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