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  • Binding Sites  (465)
  • 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems
  • 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport
  • 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy
  • 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
  • Acoustics
  • Applied geophysics
  • Data analysis / ~ processing
  • Fluids
  • Schussler
  • Textbook of geophysics
  • American Association for the Advancement of Science (AAAS)  (470)
  • Elsevier  (66)
  • Springer  (25)
  • Kluwer  (18)
  • Cambridge Univ. Press  (11)
  • Cambridge U. Press  (6)
  • Soc. of Exploration Geophys.
  • W.H. Freeman
  • 2020-2023  (2)
  • 2010-2014  (172)
  • 2000-2004  (373)
  • 1980-1984  (53)
Collection
Keywords
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 186 (2000), S. 447-465 
    ISSN: 1432-1351
    Keywords: Key words Hearing ; Middle ear ; Cat family ; Body size ; Acoustics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Is the acoustic performance of the mammalian middle ear dependent on body size? We focus on the cat family, because of its qualitatively uniform (and distinctive) middle-ear structure, large size range, and the extensive data available from domestic cats which provide a framework for relating middle-ear acoustics to structure. We report measurements of acoustic admittance in 17 live adult ears of 11 exotic species, ranging in size from sand cat (3 kg) to tiger (180 kg). For low frequencies, the middle-ear response is compliant for all species and generally increases with size. The compliance of the middle-ear air space increases with size, but the compliance of the tympanic membrane and ossicular chain is not correlated with size. Structure-based rules are developed to represent some features of middle-ear performance: (1) low-frequency sensitivity increases with size; and (2) the frequency of a prominent notch in admittance decreases with size. Although some species deviate from the rules, the data generally support the idea that in larger felids the middle-ear response is shifted to lower frequencies. Thus, in the cat family, body size partly describes variations in auditory features. More speculatively, ethological pressures which might influence hearing performance are discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 122 (1984), S. 492-530 
    ISSN: 1420-9136
    Keywords: Lithosphere ; Fluids ; Earthquakes ; Fracture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The Earth is continuously expelling gases and liquids from great depths—juvenile volatiles from the mantle and recycled metamorphic products. Some of these fluids ascend through liquid rock in volcanic processes, but others utilize fractures and faults as conduits through the solid lithosphere. The latter process may have a major influence on earthquakes, since fluids at near lithostatic pressures appear to be required to activate deep faults that would otherwise remain locked. Fluids can be driven upward through solid rock by buoyancy, but only if present in sufficient concentration to form large-scale domains occupying interconnected fracture porosity. A growing fluid domain becomes so mobilized only when it attains the critical vertical dimension required for hydrostatic instability. This dimension, depending on the ultimate compressive yield strength of the rock, may be as much as several kilometers. Any column of fluid ascending through fractures in the solid lithosphere from a prolific deep source must become organized into a vertical sequence of discrete domains, separated by fluid-pressure discontinuities. This is required because a continuous hydrostatic-fluid-pressure profile extending from an arbitrarily deep source to the surface cannot be permitted by the finite strength of rock. A vertically stacked sequence of domains allows the internal fluid-pressure profile to approximate the external rock-stress profile in a stepwise fashion. The pressure discontinuity below the base of the uppermost hydrostatic domain may be responsible for some occurrences of so-called anomalous geopressures. An ascending stream of fluid that percolates upward from a deep source through a column of domains must encounter a sequence of abrupt pressure decreases at the transitions between successive domains. If supercritical gases act as solvents, the dissolved substances may drop out of solution at such pressure discontinuities, resulting in a local concentration of minerals and other substances. At great depths, brittle fracture would normally be prevented by high pressure and temperature, with all excessive stress discharged by ductile flow. Rock strata invaded by an ascending fluid domain are weakened, however, because cracks generated or reactivated by the high-pressure fluid can support the overburden, greatly reducing internal friction. This reduction of strength may cause a previously stressed rock to fail, resulting in hydraulic shear fracture. Thus, earthquakes may be triggered by the buoyant migration of deep-source fluids. The actual timing of the failure that leads to such an earthquake may be determined by the relatively rapid inflation of a fluid domain and not by any significant increase in the probably much slower rate of regional tectonic strain. Many earthquake precursory phenomena may be secondary symptoms of an increase in pore-fluid pressure, and certain coseismic phenomena may result from the venting of high-pressure fluids when faults break the surface. Instabilities in the migration of such fluid domains may also contribute to or cause the eruption of mud volcanoes, magma volcanoes, and kimberlite pipes.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 40 (2000), S. 242-247 
    ISSN: 1741-2765
    Keywords: Acoustics ; damping ; instruments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A method for determining the tone quality of a classical guitar is described. The method is applied to several high- and low-quality classical guitars. In comparison to bad tones, the timbre of good tones consists of stronger consonant (pleasant) and weaker dissonant (unpleasant) intervals. This empirical criterion of tone quality is called the rule of consonance-dissonance (RC-D). The RC-D is defined mathematically and interpreted in physical and musical terms. The RC-D allows a luthier to pursue systematically the tone quality during guitar production and to improve the instrument's tone after its assembly.
    Type of Medium: Electronic Resource
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  • 4
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    Cambridge U. Press
    In:  New York, Cambridge U. Press, (ISBN 0-521-81734-X)
    Publication Date: 2003
    Keywords: Textbook of physics ; Textbook of geophysics ; Elasticity ; Dynamic ; Waves ; Wave propagation
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  • 5
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    Cambridge U. Press
    In:  New York, Cambridge U. Press, vol. A 744, pp. 6322, (ISBN 0-521-79203-7)
    Publication Date: 2003
    Keywords: Textbook of geophysics ; Seismics (controlled source seismology) ; Three dimensional
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  • 6
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    Elsevier
    In:  Amsterdam, Elsevier, vol. 14 B, pp. 225, (ISBN 3-7643-7011-4)
    Publication Date: 1984
    Keywords: Applied geophysics ; seismic Migration ; Seismics (controlled source seismology) ; Acoustics
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  • 7
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    Kluwer
    In:  Orlando, Florida, Kluwer, vol. 27, pp. 559-932, (1-4020-2401-0, 792 pp.)
    Publication Date: 2004
    Keywords: Proceedings of a conference ; Tomography ; Acoustics ; Seismology ; Seismics (controlled source seismology) ; Textbook of physics ; Textbook of geophysics ; Textbook of mathematics
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  • 8
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    Cambridge Univ. Press
    In:  New York (306 pp.), Cambridge Univ. Press, vol. 4, no. 3, pp. 2-203, (ISBN 0-521-80604-6, ISBN 0-521-01472-7 paper)
    Publication Date: 2001
    Keywords: Textbook of geophysics ; hot ; spots ; Plate tectonics ; ConvolutionE ; Geol. aspects
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  • 9
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    Kluwer
    In:  Dordrecht, 396 pp., Kluwer, vol. 138, no. 2, pp. 527-553, (ISBN: 1-4020-1179-2)
    Publication Date: 2003
    Keywords: Earthquake risk ; Earthquake hazard ; interdisciplinary ; Textbook of geophysics ; Textbook of geology
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  • 10
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    Cambridge U. Press
    In:  New York, Cambridge U. Press, vol. 15, no. Subvol. b, pp. 220, (ISBN 0-521-52569-1)
    Publication Date: 2004
    Keywords: Textbook of geophysics ; Time series analysis ; Inversion
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  • 11
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    Elsevier
    In:  Amsterdam, 528 pp., Elsevier, vol. 32, no. XVI:, pp. 227-235, (ISBN 0231-12739-1 hb, 0231127383 pb)
    Publication Date: 2000
    Keywords: Seismics (controlled source seismology) ; Applied geophysics ; Wave propagation ; Waves ; Acoustics ; Fluids ; Textbook of geophysics
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  • 12
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    Elsevier
    In:  Amsterdam, 346 pp., Elsevier, vol. 1, no. 1, pp. 65-66, (ISBN 3-936546-23-1, 2. Auflage 2005. 876 Seiten + CD-ROM)
    Publication Date: 2000
    Keywords: Textbook of engineering ; Textbook of geophysics ; Applied geophysics ; recovery ; hydro-carbons
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  • 13
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    Soc. of Exploration Geophys.
    In:  Tulsa, Okl., Soc. of Exploration Geophys., vol. IUGG Volume 18, no. 85, pp. 175, (3-7723-6434-9)
    Publication Date: 1982
    Keywords: Data analysis / ~ processing ; Handbook of geophysics ; Seismics (controlled source seismology)
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  • 14
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    Kluwer
    In:  Dordrecht, 308 pp., Kluwer, vol. 15, no. Publ. No. 12, pp. 585, (ISBN 0080424309)
    Publication Date: 2000
    Keywords: Earthquake hazard ; Earthquake risk ; Earthquake engineering, engineering seismology ; Textbook of geophysics ; Textbook of engineering
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  • 15
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    Springer
    In:  New York. 145 pp., Springer, vol. 4, no. Publ. No. 12, pp. 127, (3-540-43395-3)
    Publication Date: 2002
    Keywords: Rheology ; Textbook of geophysics ; Textbook of physics
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  • 16
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    Kluwer
    In:  Dordrecht, 348 pp., Kluwer, vol. 20, no. Publ. No. 12, pp. 81-89, (ISBN 1-4020-1729-4)
    Publication Date: 2003
    Keywords: GFZ ; M04.0014 ; 000266148 ; Textbook of geophysics ; Statistical investigations ; Artificial intelligence (AI) ; Seismics (controlled source seismology) ; Borehole geophys. ; Applied geophysics ; Electromagnetic methods/phenomena ; Seismology
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  • 17
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    Kluwer
    In:  Dordrecht, Kluwer, vol. 15, no. Publ. No. 12, pp. 23-40, (ISBN 1-4020-3326-5, VIII + 343 pp.)
    Publication Date: 2001
    Keywords: Textbook of geophysics ; digital signal analysis (also DSP) ; Data analysis / ~ processing ; Seismology ; Filter- ; Spectrum ; Waves ; exercises ; teaching
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  • 18
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    Elsevier
    In:  Amsterdam, Elsevier, vol. Developments in Petroleum Science vol. 15A, no. Publ. No. 12, pp. 9, (ISBN: 0-12-636380-3)
    Publication Date: 1984
    Keywords: Borehole geophys. ; Textbook of geophysics ; GFZ ; RUB ; GMG ; 3.45.8 ; UniL ; IfGuG ; in ; Französisch
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  • 19
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    Cambridge Univ. Press
    In:  Cambridge, Cambridge Univ. Press, vol. 25, no. Publ. No. 12, pp. 95-104, (ISBN: 0-08-043930-6)
    Publication Date: 2000
    Keywords: Textbook of geophysics ; Textbook of physics ; Textbook of mathematics ; cylindrical ; spherical ; coordinates ; vector ; calculus ; scale ; analysis ; linear ; algebra ; Fourier ; analysis ; Fourier transform ; complex ; integration ; Laplacian ; Green ; NOModelling ; potential ; theory ; Cartesian ; tensors ; perturbation ; Taylor ; Stokes
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  • 20
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    Kluwer
    In:  Dordrecht, 388 pp., Kluwer, vol. 26, no. Publ. No. 12, pp. 95-104, (ISBN: 1-4020-1592-5)
    Publication Date: 2003
    Description: Data assimilation is the combination of information from observations and models of a particular physical system in order to get the best possible estimate of the state of that system. The technique has wide applications across a range of earth sciences, a major application being the production of operational weather forecasts. Others include oceanography, atmospheric chemistry, climate studies, and hydrology. Data Assimilation for the Earth System is a comprehensive survey of both the theory of data assimilation and its application in a range of earth system sciences. Data assimilation is a key technique in the analysis of remote sensing observations and is thus particularly useful for those analysing the wealth of measurements from recent research satellites. This book is suitable for postgraduate students and those working on the application of data assimilation in meteorology, oceanography and other earth sciences.
    Keywords: Modelling ; Data analysis / ~ processing ; Textbook of geophysics ; Textbook of geology ; TBMeteorology
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  • 21
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    Kluwer
    In:  Dordrecht, IX+266 pp., Kluwer, vol. 3, no. ALEX(01)-FR-77-01, AFTAC Contract F08606-76-C-0025, pp. 329, (ISBN 1-903544-06-8)
    Publication Date: 2000
    Keywords: Textbook of geophysics ; Seismology ; Location ; 7215 ; Seismology ; Earthquake ; parameters ; 7219 ; Nuclear ; explosion ; seismology ; 7294 ; Instruments ; and ; techniques
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  • 22
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    Elsevier
    In:  Amsterdam, 253 pp., Elsevier, vol. 10, no. 1, pp. 1-40, (ISBN: 3-540-23712-7)
    Publication Date: 1983
    Keywords: Textbook of geophysics ; Acoustics ; Seismics (controlled source seismology) ; Waves ; Wave propagation
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  • 23
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    Cambridge Univ. Press
    In:  New York, 475 pp., Cambridge Univ. Press, vol. 17, pp. 225, (ISBN 1-4020-1408-2)
    Publication Date: 2000
    Keywords: Waves ; Textbook of physics ; Textbook of geophysics ; Non-linear effects ; Fluids ; Elasticity ; Electromagnetic methods/phenomena ; hydro-dynamics
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  • 24
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    Springer
    In:  New York, 1108 pp., Springer, vol. 96, pp. 225, (ISBN 0-471-95596-5)
    Publication Date: 1981
    Keywords: FROTH ; RUB ; GMG ; 3.15.80 ; Textbook of geophysics ; Seismology ; Waves ; Wavelet processing ; SModelling ; Dislocation ; Elasticity theory of dislocations ; Source
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  • 25
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    Kluwer
    In:  Dordrecht, 368 pp., Kluwer, vol. 70, pp. 71-83, (ISBN: 1-4020-0821-X)
    Publication Date: 2003
    Description: Preface. 1. Introduction; B. Boots, et al. Part I: Statistical models of spatial systems. Section A: Spatial statistics. 2. Geographic patterns of urban residential development; J. Lee. 3. Using local statistics for boundary characterization; B. Boots. 4. Local spatial interaction modelling based on the geographically weighted regression approach; T. Nakaya. Section B: Space-time analysis. 5. Understanding activity scheduling and rescheduling behaviour: theory and numerical illustration; Chang-Hyeon Joh, et al. 6. Geographical model of a self-organizing megalopolis with time-space convergence; I. Mizuno. 7. Epidemic modelling of HIV/AIDS transfers between eastern and western Europe; P. Smith, R. Thomas. Part II: Computational methods. Section A: Simulation models. 8. A spatial microsimulation model for social policy evaluation; D. Ballas, et al. 9. Analysis of the effect of land use patterns on the anthropogenic energy discharged from air conditioning and hot water supply using a modified CSU mesoscale model; T. Watanabe, et al. 10. Generalized Thuenen and Thuenen-Ricardo models for Asian land use; K. Konagaya. Section B: GIS models. 11. Balancing consensus and conflict with a GIS-based multi-participant, multi-criteria decision support tool; R. D. Feick, G. B. Hall. 12. Grid-based population distribution estimates from historical Japanese topographical maps using GIS: Y. Arai, S. Koike. 13. GIS modelling for rain-induced debris-flow hazards in a small watershed; S. Zhao, T. Tamura. Section C: The internet. 14. A geographical interpretation of cyberspace: preliminary analysis on the scaling tendency of information spaces; N. Shiode. 15. On modelling internet transactions as a time-dependent random walk: an application of the retail aggregate space-time trip (RASTT) model; R. G. V. Baker. 16. Development of disaster information network system in the Asian region: internet GIS for disaster information management; Y. Ogawa, et al. 17. Geographical conceptualization of cyberplaces; M. Takeyama.
    Keywords: Modelling ; Data analysis / ~ processing ; Textbook of geophysics ; Textbook of geology ; TBMeteorology
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  • 26
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    Cambridge Univ. Press
    In:  Cambridge, 287 pp., Cambridge Univ. Press, vol. 2, no. 3, pp. 2-203, (ISBN 3-0521-81830-3)
    Publication Date: 2002
    Keywords: Elasticity ; Textbook of geophysics ; Gravimetry, Gravitation ; Rheology ; Inelastic
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  • 27
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    Kluwer
    In:  Dordrecht, Kluwer, vol. 10, no. Subvol. b, pp. 220, (ISBN 1-4020-0653-5)
    Publication Date: 2002
    Keywords: Textbook of geophysics ; Earthquake ; Seismology ; Tectonics ; Plate tectonics ; Strong motions ; Sea seismics ; Geol. aspects ; Tsunami(s) ; Earthquake catalog ; Seismicity ; Velocity depth profile ; Stress ; triggering ; Earthquake hazard ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Geodesy ; Turkey ; Greece ; Goeruer ; Gorur
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  • 28
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    Cambridge Univ. Press
    In:  Cambridge, XIII+248 pp., Cambridge Univ. Press, vol. 7, no. XVI:, pp. 227-235, (ISBN 0231-12739-1 hb, 0231127383 pb)
    Publication Date: 1981
    Keywords: Seismology ; Earthquake ; Textbook of geophysics
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  • 29
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    Elsevier
    In:  Amsterdam, 530 pp., Elsevier, vol. 37, no. XVI:, pp. 227-235, (ISBN 0231-12739-1 hb, 0231127383 pb)
    Publication Date: 2002
    Keywords: Seismics (controlled source seismology) ; Applied geophysics ; Wave propagation ; Waves ; Textbook of geophysics ; Acoustics ; Fluids ; High frequency ... ; Kirchoff ; seismic Migration ; Layers ; Channel waves
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  • 30
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    Springer
    In:  Berlin, 306 pp., Springer, vol. 2, no. XVI:, pp. 1-14, (ISBN: 0-387-30752-4)
    Publication Date: 2000
    Keywords: Textbook of geophysics ; Textbook of geology ; Textbook of mathematics ; Data analysis / ~ processing ; Modelling ; Inversion
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  • 31
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    Elsevier
    In:  Amsterdam, Elsevier, vol. 81A and 81B, no. 22, pp. 65-70, (1405101733, 336 p.)
    Publication Date: 1984
    Keywords: Textbook of geophysics ; Earth model, also for more shallow analyses !
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  • 32
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    Kluwer
    In:  Dordrecht, 344 pp., Kluwer, vol. 20, no. Publ. No. 12, pp. 81-89, (ISBN 1-4020-1267-5 (hb), ISBN 1-4020-1268-3 (pb))
    Publication Date: 2004
    Keywords: Textbook of geophysics ; NOModelling ; GeodesyY ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; post-glacial ; Rheology ; Earth rotation ; Inelastic ; Seismology ; earth mantle ; post-seismic ; Dislocation
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  • 33
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    Elsevier
    In:  Amsterdam, Elsevier, vol. 65, no. ALEX(01)-FR-77-01, AFTAC Contract F08606-76-C-0025, pp. 95-104, (ISBN: 0-08-044051-7)
    Publication Date: 2000
    Keywords: Seismology ; Textbook of geophysics
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  • 34
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    Elsevier
    In:  Amsterdam, 628 pp., Elsevier, vol. 31, no. 1, pp. 1-40, (ISBN 0-691-01019-6)
    Publication Date: 2002
    Keywords: Textbook of geophysics ; Inversion ; instability ; well-posed ; ill-posed ; problems ; Least-squares ; Backus ; Gilbert ; Non-linear effects ; regularization ; potential ; Electromagnetic methods/phenomena ; Seismology ; Gram ; Schmidt ; Singular value decomposition ; Lanczos ; Green's function ; Tikhonov ; potential ; methods ; Seismics (controlled source seismology) ; Gravimetry, Gravitation ; Geomagnetics ; Textbook of mathematics ; seismic Migration
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  • 35
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    Elsevier
    In:  304 pp., Elsevier, vol. 6, no. 1, pp. 1-40, (ISBN: 0-444-51340-X)
    Publication Date: 2003
    Keywords: Seismology ; Volcanology ; Seismicity ; Seismic networks ; explosions ; tremor ; Tectonics ; Textbook of geophysics
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  • 36
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    Elsevier
    In:  Bull., Polar Proj. OP-O3A4, Signal Processing II: Theories and Applications, Bath, Elsevier, vol. 186, no. XVI:, pp. 689-692, (ISBN: 3-540-23712-7)
    Publication Date: 1983
    Keywords: Seismology ; Seismic arrays ; Spectrum ; Broad-band ; Data analysis / ~ processing ; f-k-Analysis ; Schuessler ; Schussler
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  • 37
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    Elsevier
    In:  Bull., Polar Proj. OP-O3A4, Signal Processing II: Theories and Applications, Leiden, Elsevier, vol. 11, no. XVI:, pp. 673-680, (ISBN: 3-540-23712-7)
    Publication Date: 1983
    Keywords: Seismology ; Seismics (controlled source seismology) ; Filter- ; Data analysis / ~ processing ; Schuessler ; Schussler
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  • 38
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    Springer
    In:  Bull., Open-File Rept., Zahlenwerte und Funktionen aus Naturwiss. und Technik, L.B. V-1b, Berlin, Springer, vol. 81A, no. 16, pp. 141-238, (ISBN 0080419208)
    Publication Date: 1982
    Keywords: Textbook of geophysics ; Fracture ; Rock mechanics ; Rheology
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  • 39
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    W.H. Freeman
    In:  San Francisco, W.H. Freeman, vol. 1, pp. 559-932, (ISBN 0-521-81734-X)
    Publication Date: 1980
    Keywords: Textbook of geophysics ; Seismology ; Band2 ; Spectrum ; Inversion ; Data analysis / ~ processing ; Inhomogeneity ; Dynamic ; cracks and fractures (.NE. fracturing) ; Fracture
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  • 40
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    Kluwer
    In:  Dordrecht, 368 pp., Kluwer, vol. V/1, subvol. b, pp. 559-932, (ISBN: 1-4020-1827-4)
    Publication Date: 2004
    Keywords: Earthquake engineering, engineering seismology ; Textbook of geophysics ; Textbook of engineering ; Earthquake risk ; Site amplification ; vulnerability ; microzonation ; Earthquake hazard ; CD-Rom
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  • 41
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    Kluwer
    In:  Dordrecht, 460 pp., Kluwer, vol. 12, pp. 6322, (ISBN 0-521-79203-7)
    Publication Date: 2000
    Keywords: Earthquake hazard ; Earthquake risk ; Seismology ; Earthquake engineering, engineering seismology ; Earthquake precursor: prediction research ; Earthquake precursor: chemical (Rn, water(-level,...) ; eastern ; Europe ; Caucasus ; China ; Mexico ; Textbook of geophysics ; JICA ; RADIUS ; Spitak ; Iran ; Armenia ; Georgia
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  • 42
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    Springer
    In:  New York, 348 pp., Springer, vol. 8, no. 3, pp. 2-203, (ISBN: 3-540-41598-X)
    Publication Date: 2002
    Keywords: Textbook of geophysics ; Textbook of physics ; Finite Element Method ; Finite difference method ; perfectly ; matched ; Layers ; PML ; Gauss-Labatto ; element ; shape
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  • 43
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    Cambridge U. Press
    In:  New York (573 pp.), Cambridge U. Press, vol. 10, no. 2, pp. 125-169, (ISBN 0-521-00098-X)
    Publication Date: 2001
    Keywords: Geomagnetics ; Physical properties of rocks ; Textbook of geophysics ; Oezdemir ; Ozdemir
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  • 44
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    Elsevier
    In:  Amsterdam, 304 pp., Elsevier, vol. 49, no. 2, pp. 497-504, (ISBN 0-8137-2359-0)
    Publication Date: 2000
    Keywords: Fluids ; Textbook of geophysics ; Textbook of engineering
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  • 45
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    Springer
    In:  New York, 473 pp., Springer, vol. 10, no. Subvol. b, pp. 220, (ISBN 3-540-43160-8)
    Publication Date: 2003
    Keywords: Geodesy ; Textbook of geodesy ; methods ; Data analysis / ~ processing ; Instruments ; Global Positioning System ; Very Long Baseline Interferometry ; InSAR ; geoid ; Gravimetry, Gravitation ; Earth rotation ; Strain ; visions ; for ; the ; future ; state ; of ; the ; science
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    Kluwer
    In:  Dordrecht, xii + 314 pp., Kluwer, vol. 15, no. Subvol. b, pp. 220, (ISBN 0-12-305355-2)
    Publication Date: 2000
    Keywords: Textbook of geophysics ; Induced seismicity ; Rock bursts (see also ERDSTOSS and GEBIRGSSCHLAG)
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    Elsevier
    In:  New York, Elsevier, vol. 15, no. Subvol. b, pp. 220, (ISBN 0-12-305355-2)
    Publication Date: 2004
    Keywords: Rock mechanics ; Fluids ; Stress ; Strength
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    Springer
    In:  New York, Springer, vol. III/12, Supplement to III/4, no. XVI:, pp. 1-14, (ISBN 0-87590-299-5 (soft cover))
    Publication Date: 2002
    Keywords: SOC ; FractureT ; Textbook of geophysics ; Seismicity ; Gutenberg-Richter magnitude frequency b-value ; forest ; fires ; land ; slides
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    Elsevier
    In:  Amsterdam, 300 pp., Elsevier, vol. 34, no. 22, pp. 65-70, (ISBN 3-7643-0253-4)
    Publication Date: 2001
    Keywords: Fluids ; Textbook of geophysics ; Geochemistry
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    Cambridge Univ. Press
    In:  New York, 398 pp., Cambridge Univ. Press, vol. 34, no. 22, pp. 65-70, (ISBN 3-7643-0253-4)
    Publication Date: 2000
    Keywords: Data analysis / ~ processing ; Modelling ; Statistical investigations ; Textbook of physics
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    Soc. of Exploration Geophys.
    In:  Tulsa, Okl., Soc. of Exploration Geophys., vol. 50, no. 22, pp. 65-83, (ISBN 0-87590-422-X)
    Publication Date: 1982
    Keywords: Seismics (controlled source seismology) ; Data analysis / ~ processing
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    Elsevier
    In:  Amsterdam, 360 pp., Elsevier, vol. 26, no. 22, pp. 662-664, (ISBN 0-470-87000-1 (HB), ISBN 0-470-87001-X (PB))
    Publication Date: 2002
    Description: The vertical seismic profile, acquired with an array of 3C receivers and either a single source or several arranged in a multi-component configuration, provides an ideal high fidelity calibration tool for seismic projects involved in the application of seismic anisotropy. This book catalogues the majority of specialized tools necessary to work with P-P, P-S and S-S data from such Vertical seismic profiling surveys at the acquisition design, processing and interpretation stages. In particular, it discusses 3C, 4C, 6C and 9C Vertical seismic profiling, marine and land surveys with near and multiple offsets (walkways), azimuths (walkarounds) or a combination of both. These are considered for TIH or TIV flavours of seismic anisotropy arising from cracks, fractures, sedimentary layering, and shales. The anisotropic adaptation of familiar seismic methods for velocity analysis and inversion, reflected amplitude interpretation, are given together with more multi-component specific algorithms based upon the principles dictated by the vector convolutional model. Thus, multi-component methods are described that provide tests and compensation for source or receiver vector fidelity, tool rotation correction, layer stripping, near-surface correction, wavefield separation, and the Alford rotation with its variants. The work will be of interest to geophysicists involved in research or the application of seismic anisotropy using multi-component seismic. CONTENTS 1. Introduction. 2. Anisotropic replacement media. 3. Fundamentals of seismic anisotropy analysis. 4. Pre-requisites for near-offset Vertical seismic profiling analysis. 5. Anisotropy analysis from near-offset Vertical seismic profiling I - symmetry and uniformity. 6. Anisotropy analysis from far-offset Vertical seismic profiling II - asymmetry and non-uniformity. 7. Multiple-offset Vertical seismic profiling - kinematics. 8. Multiple-offset Vertical seismic profiling - dynamics. 9. The road ahead. Appendix - shear-wave birefringence analysis.
    Keywords: Applied geophysics ; Seismics (controlled source seismology) ; Vertical seismic profiling ; Anisotropy ; Textbook of geophysics
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    Kluwer
    In:  Dordrecht, 356 pp., Kluwer, vol. 22, no. 1, pp. 799-804, (ISBN 1-4020-1777-4 (hb) and ISBN 1-4020-1778-2 (pb))
    Publication Date: 2003
    Keywords: Textbook of geophysics ; Seismology ; Seismicity ; Earthquake hazard ; Source ; Earthquake risk ; Earthquake engineering, engineering seismology ; Earthquake precursor: prediction research ; Greece ; Turkey
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    Cambridge Univ. Press
    In:  New York (343 pp.), Cambridge Univ. Press, vol. 1, no. Publ. No. 12, pp. 127, (ISBN 0-521-66034-3, ISBN 0-521-66948-0 paper)
    Publication Date: 2001
    Keywords: Textbook of geophysics ; Textbook of geology ; optics ; LASER ; RADAR
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    Elsevier
    In:  Amsterdam, 298 pp., Elsevier, vol. 70, no. Publ. No. 12, pp. 1039-1054, (ISBN 0-444-50971-2)
    Publication Date: 2001
    Keywords: Subduction zone ; Review article ; Hypocentral depth ; Fault plane solution, focal mechanism ; Seismicity ; Mineralogy ; Hilst ; triggering ; Stress ; Rheology ; Geochemistry ; Strength ; Fluids ; ConvolutionE
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    Kluwer
    In:  Dordrecht, 260 pp., Kluwer, vol. 25, no. Publ. No. 12, pp. 95-104, (ISBN: 0-08-043930-6)
    Publication Date: 2000
    Keywords: Tsunami(s) ; Earthquake catalog ; Textbook of geophysics
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    Springer
    In:  Berlin Heidelberg, Springer, vol. 98, no. ALEX(01)-FR-77-01, AFTAC Contract F08606-76-C-0025, pp. 95-104, (ISBN: 1-4020-1592-5)
    Publication Date: 2003
    Keywords: digital signal analysis (also DSP) ; DSP ; Seismology ; Early warning systems (earthquakes, volcanic eruptions, tsunamis etc.) ; earthquake ; warning ; Seismic networks ; Data analysis / ~ processing ; Location ; Detectors ; Time series analysis ; Seismology
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    Elsevier
    In:  Amsterdam, Elsevier, vol. 10, no. ALEX(01)-FR-77-01, AFTAC Contract F08606-76-C-0025, pp. 329, (ISBN: 0-08-043649-8)
    Publication Date: 2001
    Description: Following the breakthrough in the last decade in identifying the key parameters for time and depth imaging in anisotropic media and developing practical methodologies for estimating them from seismic data, this title primarily focuses on the far reaching exploration benefits of anisotropic processing. This volume provides the first comprehensive description of reflection seismic signatures and processing methods in anisotropic media. It identifies the key parameters for time and depth imaging in transversely isotropic media and describes practical methodologies for estimating them from seismic data. Also, it contains a thorough discussion of the important issues of uniqueness and stability of seismic velocity analysis in the presence of anisotropy. The book contains a complete description of anisotropic imaging methods, from the theoretical background to algorithms to implementation issues. Numerous applications to synthetic and field data illustrate the improvements achieved by the anisotropic processing and the possibility of using the estimated anisotropic parameters in lithology discrimination.
    Keywords: Textbook of geophysics ; Seismics (controlled source seismology) ; Reflection seismics ; Anisotropy
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    Cambridge Univ. Press
    In:  New York, Cambridge Univ. Press, vol. 10, no. 1, pp. 1-40, (ISBN 0-521-62272-7, ISBN 0-521-00600-7 paper)
    Publication Date: 2001
    Keywords: Textbook of geophysics ; Gravimetry, Gravitation ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Tectonics ; density
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    Elsevier
    In:  Amsterdam, 300 pp., Elsevier, vol. 4, no. 1, pp. 1-40, (ISBN 0-691-01019-6)
    Publication Date: 2002
    Keywords: Stress ; Tectonics ; Modelling ; Fluids ; Two-dimensional ; percolation ; cracks and fractures (.NE. fracturing) ; Fracture ; Three ; Gorges ; China ; Discrete / Distinct Element Method ; permeability ; Rock mechanics
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    Springer
    In:  Professional Paper, Methods and Applications of Signal Processing in Seismic Network Operations, Berlin Heidelberg, Springer, vol. 98, no. 16, pp. 131-148, (ISBN 0080419208)
    Publication Date: 2003
    Keywords: digital signal analysis (also DSP) ; DSP ; Seismology ; Early warning systems (earthquakes, volcanic eruptions, tsunamis etc.) ; earthquake ; warning ; Seismic networks ; Data analysis / ~ processing ; Location ; Detectors ; Time series analysis ; Seismology ; Boedvarsson ; Bodvarsson
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    W.H. Freeman
    In:  San Francisco, W.H. Freeman, vol. 1, pp. 1-558, (ISBN 0-521-81734-X)
    Publication Date: 1980
    Keywords: Textbook of geophysics ; Seismology ; Band1 ; Elasticity ; Source ; Fault plane solution, focal mechanism ; Waves ; Instruments ; Surface waves ; (The Earth's free) oscillations ; Reflection seismics ; Inhomogeneity ; Detectors
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    Elsevier
    In:  Amsterdam, Elsevier
    Publication Date: 1980
    Keywords: Seismology ; Seismics (controlled source seismology) ; Wave propagation ; Waves ; Textbook of geophysics
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    Springer
    In:  Berlin, Springer, vol. 45, pp. 3. erweiterte u. aktualisierte Auflage, x+419 pp., (ISBN 0-471-95596-5)
    Publication Date: 2000
    Keywords: GIS ; Textbook of geophysics ; geography ; data ; base ; fuzzy ; Data analysis / ~ processing ; interpolation ; SQL
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    Kluwer
    In:  Dordrecht, 460 pp., Kluwer, vol. 17, pp. 225, (ISBN 1-4020-1408-2)
    Publication Date: 2003
    Description: Foreword. How to climb the gravity wall; R. Rummel. I: Precise orbit determination and gravity field modelling. Strategies for precise orbit determination of low earth orbiters using the Global Positioning System; U. Hugentobler, G. Beutler. Aiming at a 1 cm orbit for low earth orbiters: reduced-dynamic and kinematic precise orbit determination; P. N. A. M. Visser, J. van den Ijssel. Space-wise, time-wise, torus and Rosborough representations in gravity field modelling; N. Sneeuw. Gravity field recovery from GRACE: unique aspects of the high precision inter-satellite data and analysis methods; G. Balmino. Global gravity field recovery using solely Global Positioning System tracking and accelerometer data from CHAMP; C. Reigber, et al. The processing of band-limited measurements: filtering techniques in the least squares context and in the presence of data gaps; W.-D. Schuh. II: Solid earth physics. Long wavelength sea level and solis surface perturbations driven by polar ice mass variations: fingerprinting Greenland and Antarctic ice sheet flux; M. E. Tamisiea, et al. Benefits from GOCE within solid earth geophysics; A. M. Marotta. The potential of GOCE in constraining the structure of the crust and lithosphere from post-glacial rebound; L. L. A. Vermeersen. Deep and shallow solid-earth structures reconstructed with sequential integrated inversion (SII) of seismic and gravity data; R. Tondi, et al. Present-day sea level change: observations and causes; A. Cazenave, et al. III: Ocean circulation. Global ocean data assimilation and geoid measurements; C. Wunsch, D. Stammer. Resolution needed for an adequate determination of the mean ocean circulation from altimetry and an improved geoid; C. Le Provost, M. Bremond. Error characteristics estimated from CHAMP, GRACE and GOCE derived geoids and from satellite altimetry derived mean dynamic topography; E. J. O. Schrama. Estimating the high-resolution mean sea-surface velocity field by combined use of altimeter and drifter data for geoid model improvement; S. Imawaki, et al. Combined use of altimetry and in situ gravity data for coastal dynamics studies; K. Haines, et al. Feasibility and contribution to ocean circulation studies of ocean bottom pressure determination; C. W. Hughes, V. Stepanov. Impact of geoid improvement on ocean mass and heat transport estimates; P. Le Grand. How operational oceanography can benefit from dynamic topography estimates as derived from altimetry and improved geoid; P. Y. Le Traon, et al. IV: Geodesy. Remarks on the role of height datum in altimetry-gravity boundary-value problems; F. Sacerdote, F. Sanso. Ocean tides in GRACE monthly averaged gravity fields; P. Knudsen. Tidal models in a new era of satellite gravimetry; R. D. Ray, et al. The elusive stationary geoid; M. Vermeer. Geodetic methods for calibration of GRACE and GOCE; J. Bouman, R. Koop. V: Sea level. Benefits of GRACE and GOCE to sea level studies; P. Woodworth, J. M. Gregory. What might GRACE contribute to studies of post glacial rebound? J. Wahr, I. Velicogna. Measuring the distribution of ocean mass using GRACE; R. S. Nerem, et al. Monitoring changes in continental water storage with GRACE; S. Swenson, J. Wahr. VI: Future concepts. Attitude and drag control: an application to the GOCE satellite; E. Canuto, et al. On superconductive gravity gradiometry in space; S. Zarembinski. Satellite-satellite laser links for future gravity missions; P. L. Bender et al. Possible future use of laser gravity gradiometers; P. L. Bender, et al. MICROSCOPE instrument development lessons for GOCE; P. Touboul. Needs and tools for future gravity measuring missions; M. Aguirre-Martinez, N. Sneeuw. VII: Closing session. GOCE: first earth explorer core mission; M. R. Drinkwater, et al. Earth gravity field from space from senors to earth sciences: closing remarks; G. Beutler.
    Keywords: Textbook of geodesy ; Earth tides ; Least-squares ; Data analysis / ~ processing ; Geodesy ; Rheology ; Inelastic ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Gravimetry, Gravitation ; Modelling
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    Springer
    In:  New York, Springer, vol. 31, no. 3, pp. 2-203, (ISBN 0-87590-533-1)
    Publication Date: 2000
    Keywords: Data analysis / ~ processing ; Error analysis ; Handbook of geophysics ; Handbook of geodesy ; toolbox ; Statistical investigations ; Inversion ; Non-linear effects ; aerial ; images ; Diffraction ; Tomography ; 1214 ; Geodesy ; and ; gravity ; Geopotential ; theory ; and ; determination ; 1224 ; Photogrammetry ; remote ; sensing ; 0902 ; Exploration ; geophysics ; Computational ; methods, ; seismic ; Gruen ; Grun
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    Elsevier
    In:  Amsterdam, 680 pp., Elsevier, vol. 33, no. 2, pp. 125-169, (ISBN: 3-540-42642-6, Approx. 620 p. 30 illus., Hardcover)
    Publication Date: 2001
    Keywords: Borehole geophys. ; Textbook of geophysics ; Electromagnetic methods/phenomena
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    Kluwer
    In:  Dordrecht, 358 pp., Kluwer, vol. 10, no. Subvol. b, pp. 220, (ISBN 1-4020-0653-5)
    Publication Date: 2002
    Keywords: Textbook of geophysics ; Seismics (controlled source seismology) ; Seismology ; Layers ; Velocity depth profile ; Physical properties of rocks
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    Cambridge Univ. Press
    In:  Cambridge, Cambridge Univ. Press, vol. 2, no. XVI:, pp. 1-14, (ISBN: 0-691-05010-4)
    Publication Date: 1980
    Keywords: Waves ; Elasticity ; Source ; Wave propagation ; Seismology ; Textbook of geophysics
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    Cambridge U. Press
    In:  New York (370 pp.), Cambridge U. Press, vol. 13, no. XVI:, pp. 227-235, (ISBN 0-521-80945-2, ISBN 0-521-00663-5 paper)
    Publication Date: 2001
    Keywords: Waves ; Wave propagation ; Textbook of geophysics ; observations ; (part ; 1), ; theory ; (part ; 2) ; Ray seismics ; Anisotropy ; Attenuation ; Elasticity
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    Elsevier
    In:  Amsterdam, 356 pp., Elsevier, vol. 2, no. XVI:, pp. 1-14, (ISBN: 0-387-30752-4)
    Publication Date: 2001
    Keywords: Textbook of engineering ; Textbook of geophysics ; Statistical investigations
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    Cambridge U. Press
    In:  New York (xii + 534 pp.), Cambridge U. Press, vol. 13, no. XVI:, pp. 227-235, (ISBN 0-521-00665-1)
    Publication Date: 2002
    Keywords: WAVE ; Wave propagation ; Textbook of geophysics ; observations ; (part ; 1), ; theory ; (part ; 2) ; Ray seismics ; Anisotropy ; AnisotropyS ; Earthquake ; Chi-Chi ; Kobe ; Loma ; Prieta ; North ; Ridge ; Tennant ; Creek ; Aftershocks ; Inhomogeneity ; basins ; Data analysis / ~ processing ; Modelling ; wavefiled ; decomposition ; Dispersion ; Three dimensional ; Earth model, also for more shallow analyses ! ; CRUST ; earth mantle ; earth Core ; D-double-prime ; ultra ; Low velocity layer ; NOModelling ; Surface waves ; Tomography ; Receiver functions ; Source ; Moment tensor ; Inversion ; perturbation ; methods ; Handbook of geophysics
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    Elsevier
    In:  Amsterdam, 656 pp., Elsevier, vol. 38, no. XVI:, pp. 227-235, (ISBN: 0-444-50983-6)
    Publication Date: 2003
    Description: The monograph introduces the reader to the world of inductive well logging - an established method for surveying the electrical conductivity of rocks surrounding a borehole. The emphasis is on developing a theory of inductive logging and on understanding logging tools basic physics, since this theory and understanding furnish valuable insights for inventing practical induction logging techniques. The first chapter of the book presents the basic laws of electromagnetism from a point of view that will facilitate the application of the theory to problems in electromagnetic logging. Many topics that play an important role in the design and interpretation of tools readings are covered. The vertical resolution and radial depth of investigation of different induction tools is systematically considered. Special attention is paid to principles of induction logging with transversal induction coils, to transient method of induction logging in media with cylindrical and horizontal interfaces and to the influence of anisotropy on the electromagnetic field measured in a conducting medium. Multi-coil differential induction probes and induction logging based on measuring the inphase component of the secondary field or the quadrature component difference are also described in detail. The last chapter is devoted to mathematical modeling of the response of induction logging tools in 3D geometries. The theory of inductive logging presented in this volume can be applied to logging after drilling as well as logging while drilling. Introduction. 1. Basic electromagnetic laws and Maxwell's equations. 2. Electromagnetic field of the magnetic dipole in a uniform conducting medium. 3. Methods for the solution of direct problems of induction logging. 4. Electromagnetic field of a vertical magnetic dipole on the axis of a borehole 5. Quasistationary magnetic field of a vertical magnetic dipole in a formation with a finite thickness. 6. The two-coil induction probe on the borehole axis, when the bed has a finite thickness. 7. Multi-coil dioeerential induction probes. 8. Induction logging based on measuring the inphase component of the secondary field or the quadrature component difference of type Q Hz(omega1) - omega1/omega2 Q Hz(omega2). 9. Transient induction logging. 10. Principles of induction logging with transversal induction coils. 11. The influence of anisotropy on the field of the magnetic dipole in a conducting medium. 12. Mathematical modeling of the response of induction logging tools in 3D geometries.
    Keywords: Borehole geophys. ; Textbook of geophysics ; Dual Induction Latero log
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    Cambridge Univ. Press
    In:  New York, Cambridge Univ. Press, vol. 22, no. 1, pp. 799-804, (ISBN 1-4020-1777-4 (hb) and ISBN 1-4020-1778-2 (pb))
    Publication Date: 2000
    Keywords: Textbook of geology ; Textbook of geophysics ; Applied geophysics ; Tectonics ; Plate tectonics ; textbook ; for ; future ; non-geophysicists
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    Cambridge Univ. Press
    In:  Cambridge, 2nd. ed. 496 pp., Cambridge Univ. Press, vol. 18, no. Publ. No. 12, pp. 267, (ISBN: 0521652235)
    Publication Date: 2002
    Keywords: Textbook of geophysics ; Seismology ; Tectonics ; Fault zone ; cracks and fractures (.NE. fracturing) ; Rock mechanics ; Laboratory measurements ; Fracture ; rate ; and ; state ; dependent ; Friction ; Stress ; scaling ; GFZ ; M ; 03.0198, ; RUB ; GMG ; 3.15.164
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    Kluwer
    In:  Dordrecht, 352 pp., Kluwer, vol. 4, no. 1, pp. 1-40, (ISBN: 1-4020-1348-5 hb, ISBN: 1-4020-1349-3 pb)
    Publication Date: 2003
    Keywords: Tsunami(s) ; Textbook of geophysics ; Textbook of geology ; Yalciner
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    Springer
    In:  Berlin, Springer, vol. 4, no. 1, pp. 1-40, (ISBN 0-06-057199-3)
    Publication Date: 2003
    Keywords: Geodesy ; Textbook of geodesy ; Handbook of geodesy ; Data analysis / ~ processing ; KSGSoft ; program ; software ; Filter- ; Error analysis
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    Springer
    In:  Bull., Open-File Rept., Methods and Applications of Signal Processing in Seismic Network Operations, Berlin Heidelberg, Springer, vol. 98, no. 16, pp. 149-172, (ISBN 1-86239-165-3, vi + 330 pp.)
    Publication Date: 2003
    Keywords: digital signal analysis (also DSP) ; DSP ; Seismology ; Early warning systems (earthquakes, volcanic eruptions, tsunamis etc.) ; Seismic networks ; Data analysis / ~ processing ; Location ; Detectors ; Time series analysis ; Seismology
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    Elsevier
    In:  Bull., Open-File Rept., Signal Processing II: Theories and Applications, Orlando, Elsevier, vol. 37, no. 16, pp. 681-684, (ISBN 1-86239-165-3, vi + 330 pp.)
    Publication Date: 1983
    Keywords: Detectors ; Seismic arrays ; Seismology ; Schuessler ; Schussler
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-23
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907122/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907122/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Falke, Joseph J -- R01 GM040731/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 22;295(5559):1480-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biophysics Program and the Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA. falke@colorado.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11859184" target="_blank"〉PubMed〈/a〉
    Keywords: Arginine/chemistry ; Binding Sites ; Catalysis ; Cyclophilin A/*chemistry/*metabolism ; Hydrogen Bonding ; Models, Molecular ; Nitrogen/chemistry ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Thermodynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, John H -- Elledge, Stephen J -- New York, N.Y. -- Science. 2002 Sep 13;297(5588):1822-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12228708" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; BRCA1 Protein/metabolism ; BRCA2 Protein/*chemistry/*metabolism ; Binding Sites ; Breast Neoplasms/genetics ; Crystallography, X-Ray ; DNA/*metabolism ; DNA Damage ; *DNA Repair ; DNA, Single-Stranded/metabolism ; DNA-Binding Proteins/metabolism ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Humans ; Mice ; Ovarian Neoplasms/genetics ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rad51 Recombinase ; Rats ; Recombination, Genetic ; Replication Protein A
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 82
    Publication Date: 2002-06-22
    Description: Positive-strand RNA viruses such as poliovirus replicate their genomes on intracellular membranes of their eukaryotic hosts. Electron microscopy has revealed that purified poliovirus RNA-dependent RNA polymerase forms planar and tubular oligomeric arrays. The structural integrity of these arrays correlates with cooperative RNA binding and RNA elongation and is sensitive to mutations that disrupt intermolecular contacts predicted by the polymerase structure. Membranous vesicles isolated from poliovirus-infected cells contain structures consistent with the presence of two-dimensional polymerase arrays on their surfaces during infection. Therefore, host cytoplasmic membranes may function as physical foundations for two-dimensional polymerase arrays, conferring the advantages of surface catalysis to viral RNA replication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyle, John M -- Bullitt, Esther -- Bienz, Kurt -- Kirkegaard, Karla -- AI-42119/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2218-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12077417" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Binding Sites ; Catalysis ; Crystallography, X-Ray ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Inclusion Bodies, Viral/metabolism/ultrastructure ; Microscopy, Electron ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Nucleic Acid Conformation ; Poliovirus/*enzymology/physiology ; Protein Conformation ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; RNA Replicase/*chemistry/isolation & purification/*metabolism/ultrastructure ; RNA, Viral/biosynthesis/*metabolism ; Viral Core Proteins/metabolism ; Virus Replication
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  • 83
    Publication Date: 2003-07-12
    Description: Direct interaction between platelet receptor glycoprotein Ibalpha (GpIbalpha) and thrombin is required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIbalpha-thrombin binding is associated with many pathological conditions,including occlusive arterial thrombosis and bleeding disorders. The crystal structure of the GpIbalpha-thrombin complex at 2.6 angstrom resolution reveals simultaneous interactions of GpIbalpha with exosite I of one thrombin molecule,and with exosite II of a second thrombin molecule. In the crystal lattice,the periodic arrangement of GpIbalpha-thrombin complexes mirrors a scaffold that could serve as a driving force for tight platelet adhesion. The details of these interactions reconcile GpIbalpha-thrombin binding modes that are presently controversial,highlighting two distinct interfaces that are potential targets for development of novel antithrombotic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dumas, John J -- Kumar, Ravindra -- Seehra, Jasbir -- Somers, William S -- Mosyak, Lidia -- New York, N.Y. -- Science. 2003 Jul 11;301(5630):222-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical and Screening Sciences, Wyeth, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12855811" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Blood Platelets/chemistry/physiology ; Crystallization ; Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Platelet Adhesiveness ; *Platelet Aggregation ; Platelet Glycoprotein GPIb-IX Complex/*chemistry/*metabolism ; Protein Binding ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Thrombin/*chemistry/*metabolism
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  • 84
    Publication Date: 2003-05-06
    Description: We have used adenosine diphosphate analogs containing electron paramagnetic resonance (EPR) spin moieties and EPR spectroscopy to show that the nucleotide-binding site of kinesin-family motors closes when the motor.diphosphate complex binds to microtubules. Structural analyses demonstrate that a domain movement in the switch 1 region at the nucleotide site, homologous to domain movements in the switch 1 region in the G proteins [heterotrimeric guanine nucleotide-binding proteins], explains the EPR data. The switch movement primes the motor both for the free energy-yielding nucleotide hydrolysis reaction and for subsequent conformational changes that are crucial for the generation of force and directed motion along the microtubule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naber, Nariman -- Minehardt, Todd J -- Rice, Sarah -- Chen, Xiaoru -- Grammer, Jean -- Matuska, Marija -- Vale, Ronald D -- Kollman, Peter A -- Car, Roberto -- Yount, Ralph G -- Cooke, Roger -- Pate, Edward -- AR39643/AR/NIAMS NIH HHS/ -- AR42895/AR/NIAMS NIH HHS/ -- DK05915/DK/NIDDK NIH HHS/ -- GM29072/GM/NIGMS NIH HHS/ -- RR1081/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2003 May 2;300(5620):798-801.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of California, San Francisco, CA 94143, USA. naber@itsa.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12730601" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/*metabolism ; Adenosine Diphosphate/analogs & derivatives/metabolism ; Adenosine Triphosphate/analogs & derivatives/metabolism ; Animals ; Binding Sites ; Computer Simulation ; Crystallography, X-Ray ; *Drosophila Proteins ; Drosophila melanogaster ; Electron Spin Resonance Spectroscopy ; Humans ; Hydrogen Bonding ; Hydrolysis ; Kinesin/*chemistry/*metabolism ; Microtubules/*metabolism ; Models, Molecular ; Molecular Motor Proteins/*chemistry/*metabolism ; Molecular Probes/metabolism ; Protein Conformation ; Spin Labels
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  • 85
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-02-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hederstedt, Lars -- New York, N.Y. -- Science. 2003 Jan 31;299(5607):671-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Organism Biology, Lund University, SE-22362 Lund, Sweden. lars.hederstedt@cob.lu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12560540" target="_blank"〉PubMed〈/a〉
    Keywords: Aerobiosis ; Anaerobiosis ; Binding Sites ; Crystallography, X-Ray ; Electron Transport ; Electron Transport Complex II ; Escherichia coli/*enzymology ; Flavin-Adenine Dinucleotide/metabolism ; Heme/chemistry/metabolism ; Models, Molecular ; Multienzyme Complexes/antagonists & inhibitors/*chemistry/*metabolism ; Oxidation-Reduction ; Oxidoreductases/antagonists & inhibitors/*chemistry/*metabolism ; Protein Conformation ; Protein Structure, Tertiary ; Protein Subunits/chemistry ; Reactive Oxygen Species/metabolism ; Succinate Dehydrogenase/antagonists & inhibitors/*chemistry/*metabolism ; Succinic Acid/metabolism ; Ubiquinone/chemistry/metabolism
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  • 86
    Publication Date: 2003-09-13
    Description: During spliceosome activation, a large structural rearrangement occurs that involves the release of two small nuclear RNAs, U1 and U4, and the addition of a protein complex associated with Prp19p. We show here that the Prp19p-associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is dissociated. Ultraviolet crosslinking analysis revealed the existence of two modes of base pairing between U6 and the 5' splice site, as well as a switch of such base pairing from one to the other that required the Prp19p-associated complex during spliceosome activation. Moreover, a Prp19p-dependent structural change in U6 small nuclear ribonucleoprotein particles was detected that involves destabilization of Sm-like (Lsm) proteins to bring about interactions between the Lsm binding site of U6 and the intron sequence near the 5' splice site, indicating dynamic association of Lsm with U6 and a direct role of Lsm proteins in activation of the spliceosome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, Shih-Peng -- Kao, Der-I -- Tsai, Wei-Yu -- Cheng, Soo-Chen -- New York, N.Y. -- Science. 2003 Oct 10;302(5643):279-82. Epub 2003 Sep 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Microbiology and Immunology, National Yang-Ming University, Shih-Pai, Taiwan, Republic of China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12970570" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Base Pairing ; Binding Sites ; Blotting, Northern ; Introns ; Molecular Sequence Data ; RNA Precursors/metabolism ; RNA Splicing ; RNA, Small Nuclear/metabolism ; RNA-Binding Proteins/chemistry/metabolism ; Ribonuclease H/metabolism ; Ribonucleoprotein, U4-U6 Small Nuclear/chemistry/*metabolism ; Saccharomyces cerevisiae Proteins/*metabolism ; Spliceosomes/*metabolism
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  • 87
    Publication Date: 2003-05-10
    Description: Multidrug efflux pumps cause serious problems in cancer chemotherapy and treatment of bacterial infections. Yet high-resolution structures of ligand transporter complexes have previously been unavailable. We obtained x-ray crystallographic structures of the trimeric AcrB pump from Escherichia coli with four structurally diverse ligands. The structures show that three molecules of ligands bind simultaneously to the extremely large central cavity of 5000 cubic angstroms, primarily by hydrophobic, aromatic stacking and van der Waals interactions. Each ligand uses a slightly different subset of AcrB residues for binding. The bound ligand molecules often interact with each other, stabilizing the binding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yu, Edward W -- McDermott, Gerry -- Zgurskaya, Helen I -- Nikaido, Hiroshi -- Koshland, Daniel E Jr -- AI 09644/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2003 May 9;300(5621):976-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12738864" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Infective Agents/chemistry/metabolism ; Anti-Infective Agents, Local/chemistry/metabolism ; Binding Sites ; Carrier Proteins/*chemistry/isolation & purification/*metabolism ; Cell Membrane/chemistry ; Chemistry, Physical ; Ciprofloxacin/chemistry/metabolism ; Crystallization ; Crystallography, X-Ray ; Dequalinium/chemistry/metabolism ; Escherichia coli Proteins/*chemistry/isolation & purification/*metabolism ; Ethidium/chemistry/metabolism ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Ligands ; Membrane Proteins/*chemistry/isolation & purification/*metabolism ; Models, Molecular ; Multidrug Resistance-Associated Proteins ; Physicochemical Phenomena ; Protein Binding ; Protein Conformation ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rhodamines/chemistry/metabolism ; Static Electricity
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  • 88
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-03-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allen, John F -- New York, N.Y. -- Science. 2003 Mar 7;299(5612):1530-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Biochemistry, Center for Chemistry and Chemical Engineering, Box 124, Lund University, SE-221 00 Lund, Sweden. john.allen@plantbio.lu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12624254" target="_blank"〉PubMed〈/a〉
    Keywords: Algal Proteins/chemistry/genetics/isolation & purification/metabolism ; Animals ; Binding Sites ; Chlamydomonas reinhardtii/*enzymology/genetics/metabolism ; Chlorophyll/metabolism ; Electron Transport ; Fluorescence ; Gene Library ; Light ; Light-Harvesting Protein Complexes ; Models, Biological ; Mutation ; Oxidation-Reduction ; Phosphorylation ; Photosynthesis ; Photosynthetic Reaction Center Complex Proteins/*metabolism ; Plastoquinone/metabolism ; Protein-Serine-Threonine Kinases/chemistry/genetics/*isolation & ; purification/*metabolism ; Signal Transduction ; Thylakoids/*enzymology ; Transcription, Genetic
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  • 89
    Publication Date: 2000-01-05
    Description: Phytochromes are a family of photoreceptors used by green plants to entrain their development to the light environment. The distribution of these chromoproteins has been expanded beyond photoautotrophs with the discovery of phytochrome-like proteins in the nonphotosynthetic eubacteria Deinococcus radiodurans and Pseudomonas aeruginosa. Like plant phytochromes, the D. radiodurans receptor covalently binds linear tetrapyrroles autocatalytically to generate a photochromic holoprotein. However, the attachment site is distinct, using a histidine to potentially form a Schiff base linkage. Sequence homology and mutational analysis suggest that D. radiodurans bacteriophytochrome functions as a light-regulated histidine kinase, which helps protect the bacterium from visible light.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, S J -- Vener, A V -- Vierstra, R D -- New York, N.Y. -- Science. 1999 Dec 24;286(5449):2517-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Genetics, Cellular and Molecular Biology Program and Department of Horticulture, University of Wisconsin-Madison, 1575 Linden Drive, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10617469" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acid Substitution ; Bacterial Proteins/chemistry/genetics/*metabolism ; Biliverdine/analogs & derivatives/metabolism ; Binding Sites ; Gram-Positive Cocci/genetics/*metabolism ; Histidine/metabolism ; Light ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Photoreceptors, Microbial/chemistry/genetics/*metabolism ; Phytochrome/metabolism ; Protein Kinases/chemistry/genetics/*metabolism ; Pseudomonas aeruginosa/*metabolism ; Signal Transduction
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  • 90
    Publication Date: 2000-01-05
    Description: Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell-specific growth factors. Direct comparison of transgenic mice overexpressing these factors in the skin revealed that the VEGF-induced blood vessels were leaky, whereas those induced by Ang1 were nonleaky. Moreover, vessels in Ang1-overexpressing mice were resistant to leaks caused by inflammatory agents. Coexpression of Ang1 and VEGF had an additive effect on angiogenesis but resulted in leakage-resistant vessels typical of Ang1. Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thurston, G -- Suri, C -- Smith, K -- McClain, J -- Sato, T N -- Yancopoulos, G D -- McDonald, D M -- HL-24136/HL/NHLBI NIH HHS/ -- HL-59157/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1999 Dec 24;286(5449):2511-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0452, USA. gavint@itsa.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10617467" target="_blank"〉PubMed〈/a〉
    Keywords: Angiopoietin-1 ; Animals ; Arterioles/anatomy & histology/physiology ; Binding Sites ; Capillaries/anatomy & histology/physiology ; *Capillary Permeability ; Ear ; Endothelial Growth Factors/genetics/*physiology ; Endothelium, Vascular/metabolism ; Inflammation/chemically induced ; Inflammation Mediators/pharmacology ; Lymphokines/genetics/*physiology ; Membrane Glycoproteins/genetics/*physiology ; Mice ; Mice, Transgenic ; Microcirculation/anatomy & histology/*physiology ; Mustard Plant ; *Neovascularization, Physiologic ; Plant Extracts/pharmacology ; Plant Lectins ; Plant Oils ; Plants, Medicinal ; Platelet Activating Factor/pharmacology ; Ricin/metabolism ; Serotonin/pharmacology ; Skin/blood supply/metabolism ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Venules/anatomy & histology/physiology
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  • 91
    Publication Date: 2000-08-01
    Description: The path of the nucleic acids through a transcription elongation complex was tracked by mapping cross-links between bacterial RNA polymerase (RNAP) and transcript RNA or template DNA onto the x-ray crystal structure. In the resulting model, the downstream duplex DNA is nestled in a trough formed by the beta' subunit and enclosed on top by the beta subunit. In the RNAP channel, the RNA/DNA hybrid extends from the enzyme active site, along a region of the beta subunit harboring rifampicin resistance mutations, to the beta' subunit "rudder." The single-stranded RNA is then extruded through another channel formed by the beta-subunit flap domain. The model provides insight into the functional properties of the transcription complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korzheva, N -- Mustaev, A -- Kozlov, M -- Malhotra, A -- Nikiforov, V -- Goldfarb, A -- Darst, S A -- GM30717/GM/NIGMS NIH HHS/ -- GM49242/GM/NIGMS NIH HHS/ -- GM53759/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Jul 28;289(5479):619-25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Public Health Research Institute, 455 First Avenue, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10915625" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Cross-Linking Reagents ; Crystallography, X-Ray ; DNA/chemistry/genetics/*metabolism ; DNA Primers ; DNA-Directed RNA Polymerases/*chemistry/genetics/metabolism ; Models, Molecular ; Mutation ; Nucleic Acid Conformation ; Nucleic Acid Hybridization ; Oligodeoxyribonucleotides/chemistry/metabolism ; Oligoribonucleotides/chemistry/metabolism ; Protein Conformation ; Protein Structure, Tertiary ; RNA, Messenger/chemistry/genetics/*metabolism ; Templates, Genetic ; Thermus/enzymology ; *Transcription, Genetic
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  • 92
    Publication Date: 2000-01-15
    Description: Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class Ib proteins that bind to certain gammadelta T cell receptors (TCRs) in the absence of other components. The crystal structure of T22b at 3.1 angstroms reveals similarities to MHC class I molecules, but one side of the normal peptide-binding groove is severely truncated, which allows direct access to the beta-sheet floor. Potential gammadelta TCR-binding sites can be inferred from functional mapping of T10 and T22 point mutants and allelic variants. Thus, T22 represents an unusual variant of the MHC-like fold and indicates that gammadelta and alphabeta TCRs interact differently with their respective MHC ligands.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wingren, C -- Crowley, M P -- Degano, M -- Chien, Y -- Wilson, I A -- AI33431/AI/NIAID NIH HHS/ -- CA58896/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2000 Jan 14;287(5451):310-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10634787" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Amino Acid Substitution ; Animals ; Binding Sites ; Crystallography, X-Ray ; Glycosylation ; Histocompatibility Antigens Class I/*chemistry ; Hydrogen Bonding ; Ligands ; Mice ; Models, Molecular ; Point Mutation ; Protein Conformation ; Protein Folding ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Proteins/*chemistry/immunology/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/immunology/*metabolism ; Surface Properties ; beta 2-Microglobulin/chemistry
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  • 93
    Publication Date: 2000-01-22
    Description: The genome sequences of certain archaea do not contain recognizable cysteinyl-transfer RNA (tRNA) synthetases, which are essential for messenger RNA-encoded protein synthesis. However, a single cysteinyl-tRNA synthetase activity was detected and purified from one such organism, Methanococcus jannaschii. The amino-terminal sequence of this protein corresponded to the predicted sequence of prolyl-tRNA synthetase. Biochemical and genetic analyses indicated that this archaeal form of prolyl-tRNA synthetase can synthesize both cysteinyl-tRNA(Cys) and prolyl-tRNA(Pro). The ability of one enzyme to provide two aminoacyl-tRNAs for protein synthesis raises questions about concepts of substrate specificity in protein synthesis and may provide insights into the evolutionary origins of this process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stathopoulos, C -- Li, T -- Longman, R -- Vothknecht, U C -- Becker, H D -- Ibba, M -- Soll, D -- New York, N.Y. -- Science. 2000 Jan 21;287(5452):479-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10642548" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acyl-tRNA Synthetases/chemistry/genetics/isolation & ; purification/*metabolism ; Binding Sites ; Cysteine/metabolism/pharmacology ; Escherichia coli/genetics/growth & development ; Evolution, Molecular ; Genes, Archaeal ; Methanococcus/*enzymology/genetics ; Multienzyme Complexes/chemistry/genetics/isolation & purification/*metabolism ; Proline/metabolism/pharmacology ; RNA, Transfer, Amino Acyl/*biosynthesis ; Sequence Analysis, Protein ; Substrate Specificity ; Transfer RNA Aminoacylation ; Transformation, Bacterial
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  • 94
    Publication Date: 2000-06-10
    Description: Cyclic nucleotides are second messengers that are essential in vision, muscle contraction, neurotransmission, exocytosis, cell growth, and differentiation. These molecules are degraded by a family of enzymes known as phosphodiesterases, which serve a critical function by regulating the intracellular concentration of cyclic nucleotides. We have determined the three-dimensional structure of the catalytic domain of phosphodiesterase 4B2B to 1.77 angstrom resolution. The active site has been identified and contains a cluster of two metal atoms. The structure suggests the mechanism of action and basis for specificity and will provide a framework for structure-assisted drug design for members of the phosphodiesterase family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, R X -- Hassell, A M -- Vanderwall, D -- Lambert, M H -- Holmes, W D -- Luther, M A -- Rocque, W J -- Milburn, M V -- Zhao, Y -- Ke, H -- Nolte, R T -- AI33072/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2000 Jun 9;288(5472):1822-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Structural Chemistry, Department of Molecular Sciences, Glaxo Wellcome Research and Development, Research Triangle Park, NC 27709, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10846163" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases/*chemistry/*metabolism ; Binding Sites ; Catalytic Domain ; Crystallization ; Crystallography, X-Ray ; Cyclic AMP/chemistry/*metabolism ; Cyclic GMP/chemistry/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Hydrogen Bonding ; Hydrolysis ; Metals/metabolism ; Models, Molecular ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Substrate Specificity
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  • 95
    Publication Date: 2000-12-23
    Description: Understanding how DNA binding proteins control global gene expression and chromosomal maintenance requires knowledge of the chromosomal locations at which these proteins function in vivo. We developed a microarray method that reveals the genome-wide location of DNA-bound proteins and used this method to monitor binding of gene-specific transcription activators in yeast. A combination of location and expression profiles was used to identify genes whose expression is directly controlled by Gal4 and Ste12 as cells respond to changes in carbon source and mating pheromone, respectively. The results identify pathways that are coordinately regulated by each of the two activators and reveal previously unknown functions for Gal4 and Ste12. Genome-wide location analysis will facilitate investigation of gene regulatory networks, gene function, and genome maintenance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ren, B -- Robert, F -- Wyrick, J J -- Aparicio, O -- Jennings, E G -- Simon, I -- Zeitlinger, J -- Schreiber, J -- Hannett, N -- Kanin, E -- Volkert, T L -- Wilson, C J -- Bell, S P -- Young, R A -- New York, N.Y. -- Science. 2000 Dec 22;290(5500):2306-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11125145" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Cell Cycle ; DNA, Fungal/genetics/metabolism ; DNA-Binding Proteins/*metabolism ; Fungal Proteins/*metabolism ; Galactose/metabolism ; *Gene Expression Profiling ; *Gene Expression Regulation, Fungal ; Genes, Fungal ; *Genome, Fungal ; Oligonucleotide Array Sequence Analysis ; Peptides/pharmacology ; Promoter Regions, Genetic ; Saccharomyces cerevisiae/*genetics/metabolism/physiology ; *Saccharomyces cerevisiae Proteins ; Transcription Factors/*metabolism ; Transcriptional Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
    Publication Date: 2000-07-06
    Description: A conserved domain in the extracellular region of the 60- and 80-kilodalton tumor necrosis factor receptors (TNFRs) was identified that mediates specific ligand-independent assembly of receptor trimers. This pre-ligand-binding assembly domain (PLAD) is physically distinct from the domain that forms the major contacts with ligand, but is necessary and sufficient for the assembly of TNFR complexes that bind TNF-alpha and mediate signaling. Other members of the TNFR superfamily, including TRAIL receptor 1 and CD40, show similar homotypic association. Thus, TNFRs and related receptors appear to function as preformed complexes rather than as individual receptor subunits that oligomerize after ligand binding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, F K -- Chun, H J -- Zheng, L -- Siegel, R M -- Bui, K L -- Lenardo, M J -- New York, N.Y. -- Science. 2000 Jun 30;288(5475):2351-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10875917" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Antigens, CD/chemistry/metabolism ; Apoptosis ; Binding Sites ; Cross-Linking Reagents ; Dimerization ; Energy Transfer ; Fluorescence ; Humans ; Ligands ; Macromolecular Substances ; Mutation ; Protein Conformation ; Protein Structure, Tertiary ; Receptors, Tumor Necrosis Factor/*chemistry/*metabolism ; Receptors, Tumor Necrosis Factor, Type I ; Receptors, Tumor Necrosis Factor, Type II ; Recombinant Fusion Proteins/chemistry/metabolism ; *Signal Transduction ; Succinimides ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/*metabolism
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
    Publication Date: 2000-10-20
    Description: Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR). In situ binding and organ culture studies indicate that EDA-A1 and EDA-A2 are differentially expressed and play a role in epidermal morphogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yan, M -- Wang, L C -- Hymowitz, S G -- Schilbach, S -- Lee, J -- Goddard, A -- de Vos, A M -- Gao, W Q -- Dixit, V M -- New York, N.Y. -- Science. 2000 Oct 20;290(5491):523-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11039935" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Binding Sites ; Cell Line ; DNA-Binding Proteins/metabolism ; Ectodermal Dysplasia/genetics ; Ectodysplasins ; Epidermis/embryology/*metabolism ; Humans ; *I-kappa B Proteins ; In Situ Hybridization ; Ligands ; Membrane Proteins/*chemistry/*metabolism ; Mice ; Models, Molecular ; Molecular Sequence Data ; Morphogenesis ; NF-kappa B/metabolism ; Phosphorylation ; Point Mutation ; Protein Conformation ; Proteins/metabolism ; Receptors, Cell Surface/chemistry/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; TNF Receptor-Associated Factor 6 ; Transfection
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
    Publication Date: 2000-02-11
    Description: Gradients of chemoattractants elicit signaling events at the leading edge of a cell even though chemoattractant receptors are uniformly distributed on the cell surface. In highly polarized Dictyostelium discoideum amoebas, membrane-associated betagamma subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins) were localized in a shallow anterior-posterior gradient. A uniformly applied chemoattractant generated binding sites for pleckstrin homology (PH) domains on the inner surface of the membrane in a pattern similar to that of the Gbetagamma subunits. Loss of cell polarity resulted in uniform distribution of both the Gbetagamma subunits and the sensitivity of PH domain recruitment. These observations indicate that Gbetagamma subunits are not sufficiently localized to restrict signaling events to the leading edge but that their distribution may determine the relative chemotactic sensitivity of polarized cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jin, T -- Zhang, N -- Long, Y -- Parent, C A -- Devreotes, P N -- GM-28007/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Feb 11;287(5455):1034-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10669414" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Cell Membrane/metabolism ; Cell Polarity ; Chemotactic Factors/pharmacology ; Chemotaxis/*physiology ; Cyclic AMP/pharmacology ; Dictyostelium/metabolism/*physiology ; *GTP-Binding Protein beta Subunits ; *GTP-Binding Protein gamma Subunits ; GTP-Binding Proteins/*metabolism ; *Heterotrimeric GTP-Binding Proteins ; Recombinant Fusion Proteins/metabolism ; Signal Transduction
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
    Publication Date: 2000-08-19
    Description: In thioredoxin reductase (TrxR) from Escherichia coli, cycles of reduction and reoxidation of the flavin adenine dinucleotide (FAD) cofactor depend on rate-limiting rearrangements of the FAD and NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) domains. We describe the structure of the flavin-reducing conformation of E. coli TrxR at a resolution of 3.0 angstroms. The orientation of the two domains permits reduction of FAD by NADPH and oxidation of the enzyme dithiol by the protein substrate, thioredoxin. The alternate conformation, described by Kuriyan and co-workers, permits internal transfer of reducing equivalents from reduced FAD to the active-site disulfide. Comparison of these structures demonstrates that switching between the two conformations involves a "ball-and-socket" motion in which the pyridine nucleotide-binding domain rotates by 67 degrees.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lennon, B W -- Williams, C H Jr -- Ludwig, M L -- GM16429/GM/NIGMS NIH HHS/ -- GM18723/GM/NIGMS NIH HHS/ -- GM21444/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Aug 18;289(5482):1190-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biophysics Research Division, Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10947986" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Catalysis ; Crystallography, X-Ray ; Escherichia coli/*enzymology ; Flavin-Adenine Dinucleotide/metabolism ; Hydrogen Bonding ; Models, Molecular ; NADP/metabolism ; Oxidation-Reduction ; Protein Conformation ; Protein Structure, Tertiary ; Thioredoxin-Disulfide Reductase/*chemistry/*metabolism ; Thioredoxins/metabolism
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-08-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, K -- New York, N.Y. -- Science. 2000 Jun 30;288(5475):2319.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10917828" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Binding Sites ; Consensus Sequence ; Conserved Sequence ; DNA-Binding Proteins/*metabolism ; *Databases, Factual ; GATA3 Transcription Factor ; Gene Expression Regulation ; Humans ; Interleukins/*genetics ; NFATC Transcription Factors ; *Nuclear Proteins ; Trans-Activators/*metabolism ; Transcription Factors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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