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  • Wiley  (84,334)
  • Nature Publishing Group
  • 2010-2014  (57,890)
  • 2005-2009  (31,112)
  • 2013  (34,864)
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  • 1
    Publication Date: 2019-03-08
    Description: Coccolithophores have influenced the global climate for over 200 million years1. These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems2. They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering themvisible fromspace3.Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean4. Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate thatE. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
    Repository Name: EPIC Alfred Wegener Institut
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  • 2
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    Wiley
    In:  EPIC3Journal of Geophysical Research-Earth Surface, Wiley, 118(4), pp. 2546-2556, ISSN: 0148-0227
    Publication Date: 2016-11-15
    Description: The roughness of a glacier bed has high importance for the estimation of the sliding velocity and can also provide valuable insights into the dynamics and history of ice sheets, depending on scale. Measurement of basal properties in present-day ice sheets is restricted to ground-penetrating radar and seismics, with surveys retrieving relatively coarse data sets. Deglaciated areas, like the Barents Sea, can be surveyed by shipborne 2-D and 3-D seismics and multibeam sonar and provide the possibility of studying the basal roughness of former ice sheets and ice streams with high resolution. Here, for the first time, we quantify the subglacial roughness of the former Barents Sea ice sheet by estimating the spectral roughness of the basal topography. We also make deductions about the past flow directions by investigating how the roughness varies along a 2-D line as the orientation of the line changes. Lastly, we investigate how the estimated basal roughness is affected by the resolution of the basal topography data set by comparing the spectral roughness along a cross section using various sampling intervals. We find that the roughness typically varies on a similar scale as for other previously marine-inundated areas in West Antarctica, with subglacial troughs having very low roughness, consistent with fast ice flow and high rates of basal erosion. The resolution of the data set seems to be of minor importance when comparing roughness indices calculated with a fixed profile length. A strong dependence on track orientation is shown for all wavelengths, with profiles having higher roughness across former flow directions than along them.
    Repository Name: EPIC Alfred Wegener Institut
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  • 3
    Publication Date: 2017-01-30
    Repository Name: EPIC Alfred Wegener Institut
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  • 4
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    Wiley
    In:  EPIC3Journal of Geophysical Research-Earth Surface, Wiley, 115, pp. F04032, ISSN: 0148-0227
    Publication Date: 2016-11-14
    Description: Recent advances in three‐dimensional (3D) imaging of snow and firn combined with numerical modeling of flow through complex geometries have greatly improved the ability to predict permeability values based on microstructure. In this work, we combined 3D reconstructions of polar firn microstructure obtained from microcomputed tomography (mCT) and a 3D lattice‐Boltzmann (LB) model of air flow. We compared the modeled results to measurements of permeability for polar firn with a wide range of grain and pore‐scale characteristics. The results show good agreement between permeability measurements and calculated permeability values from the LB model over a wide range of sample types. The LB model is better at predicting measured permeability values than traditional empirical equations for polar firn.
    Repository Name: EPIC Alfred Wegener Institut
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  • 5
    Publication Date: 2015-10-21
    Repository Name: EPIC Alfred Wegener Institut
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  • 6
    Publication Date: 2019-07-17
    Description: Enhancement of ocean alkalinity using calcium compounds, e.g., lime has been proposed to mitigate further increase of atmospheric CO2 and ocean acidification due to anthropogenic CO2 emissions. Using a global model, we show that such alkalinization has the potential to preserve pH and the saturation state of carbonate minerals at close to today’s values. Effects of alkalinization persist after termination: Atmospheric CO2 and pH do not return to unmitigated levels. Only scenarios in which large amounts of alkalinity (i.e., in a ratio of 2:1 with respect to emitted CO2) are added over large ocean areas can boost oceanic CO2 uptake sufficiently to avoid further ocean acidification on the global scale, thereby elevating some key biogeochemical parameters, e.g., pH significantly above preindustrial levels. Smaller-scale alkalinization could counteract ocean acidification on a subregional or even local scale, e.g., in upwelling systems. The decrease of atmospheric CO2 would then be a small side effect.
    Repository Name: EPIC Alfred Wegener Institut
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  • 7
    Publication Date: 2017-04-04
    Description: Stress can undergo rapid temporal changes in volcanic environments, and this is particularly true during eruptions. We use two independent methods, coda wave interferometry (CWI) and shear wave splitting (SWS) analysis to track stress related wave propagation effects during the waning phase of the 2002 NE fissure eruption at Mt Etna. CWI is used to estimate temporal changes in seismic wave velocity, while SWS is employed to monitor changes in elastic anisotropy. We analyse seismic doublets, detecting temporal changes both in wave velocities and anisotropy, consistent with observed eruptive activity. In particular, syn-eruptive wave propagation changes indicate a depressurization of the system, heralding the termination of the eruption, which occurs three days later.
    Description: Published
    Description: 1779-1788
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Interferometry ; Seismic anisotropy ; Volcano seismology ; Volcano monitoring ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 8
    Publication Date: 2017-04-04
    Description: Stromboli is a 3000 m high island volcano, rising to 900 m above sea-level. It is the most active volcano of the Aeolian Archipelago in the Tyrrhenian Sea (Italy). Major, large volume (1 km3) sector collapses, four occurring in the last 13 kyr, have played an important role in shaping the north-western flank (Sciara del Fuoco) of the volcano, potentially generating a high-risk tsunami hazard for the Aeolian Islands and the Italian coast. However, smaller volume, partial collapses of the Sciara del Fuoco have been shown to be more frequent tsunami-generating events. One such event occurred on 30 December 2002, when a partial collapse of the north-western flank of the island took place. The resulting landslide generated 10 m high tsunami waves that impacted the island. Multibeam bathymetry, side-scan sonar imaging and visual observations reveal that the landslide deposited 25 to 30 × 106 m3 of sediment on the submerged slope offshore from the Sciara del Fuoco. Two contiguous main deposit facies are recognized: (i) a chaotic, coarse-grained (metre-sized to centimetre-sized clasts) deposit; and (ii) a sand deposit containing a lower, cross-bedded sand layer and an upper structureless pebbly sand bed capped by sea floor ripple bedforms. The sand facies develops adjacent to and partially overlying the coarse deposits. Characteristics of the deposits suggest that they were derived from cohesionless, sandy matrix density flows. Flow rheology and dynamics led to the segregation of the density flow into sand-rich and clast-rich regions. A range of density flow transitions, both in space and in time, caused principally by particle concentration and grain-size partitioning within cohesionless parent flows was identified in the deposits of this relatively small-scale submarine landslide event.
    Description: Published
    Description: 1488-1504
    Description: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: reserved
    Keywords: Flow transitions ; island volcano ; subaqueous cohesionless density flows ; submarine landslide deposits ; 04. Solid Earth::04.04. Geology::04.04.04. Marine geology ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 9
    Publication Date: 2017-04-04
    Description: A series of computer microtomography experiments are reported which were performed by using a third-generation synchrotron radiation source on volcanic rocks from various active hazardous volcanoes in Italy and other volcanic areas in the world. The applied technique allowed the internal structure of the investigated material to be accurately imaged at the micrometer scale and three-dimensional views of the investigated samples to be produced as well as three-dimensional quantitative measurements of textural features. Thegeometryof thevesicle (gas-filledvoid) network in volcanic products of both basaltic and trachytic compositions were particularly focused on, as vesicle textures are directly linked to the dynamics of volcano degassing. This investigation provided novel insights into modes of gas exsolution, transport and loss in magmas that were not recognized in previous studies using solely conventional two- dimensional imaging techniques. The results of this study are important to understanding the behaviour of volcanoes and can be combined with other geosciences disciplines to forecast their future activity.
    Description: In press
    Description: 2.3. TTC - Laboratori di chimica e fisica delle rocce
    Description: JCR Journal
    Description: reserved
    Keywords: high-resolution three-dimensional imaging ; X-ray computed microtomography ; volcanic eruptions ; volcanic rock textures ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 10
    Publication Date: 2017-04-04
    Description: We present a duration-amplitude procedure for rapid determination of a moment magnitude, Mwpd, for large earthquakes using P-wave recordings at teleseismic distances. Mwpd can be obtained within 20 minutes or less after the event origin time as the required data is currently available in near-real time. The procedure determines apparent source durations, T0, from high-frequency, P-wave records, and estimates moments through integration of broadband displacement waveforms over the interval tP to tP+T0, where tP is the P arrival time. We apply the duration-amplitude methodology to 79 recent, large earthquakes (Global Centroid- Moment Tensor magnitude, MwCMT, 6.6 to 9.3) with diverse source types. The results show that a scaling of the moment estimates for interplate thrust and possibly tsunami earthquakes is necessary to best match MwCMT. With this scaling, Mwpd matches MwCMT typically within ±0.2 magnitude units, with a standard deviation of σ=0.11, equaling or outperforming other approaches to rapid magnitude determination. Furthermore, Mwpd does not exhibit saturation; that is, for the largest events, Mwpd does not systematically underestimate MwCMT. The obtained durations and duration-amplitude moments allow rapid estimation of an energy-to-moment parameter Θ* used for identification of tsunami earthquakes. Our results show that Θ* ≤ -5.7 is an appropriate cutoff for this identification, but also show that neither Θ* nor Mw is a good indicator for tsunamigenic events in general. For these events we find that a reliable indicator is simply that the duration T0 is greater than about 50 sec. The explicit use of the source duration for integration of displacement seismograms, the moment scaling, and other characteristics of the duration-amplitude methodology make it an extension of the widely used, Mwp, rapid-magnitude procedure. The need for a moment scaling for interplate thrust and possibly tsunami earthquakes may have important implications for the source physics of these events.
    Description: DPC-INGV (2007-2009) S3 Project
    Description: Published
    Description: 200-214
    Description: 3.1. Fisica dei terremoti
    Description: JCR Journal
    Description: open
    Keywords: earthquakes, Richter magnitude, seismic moment, seismograms, tsunami,  earthquake­source mechanism ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 11
    Publication Date: 2017-04-04
    Description: Rapid extension and active normal faulting in the western extremity of the Corinth Gulf are accompanied by fast coastal uplift.We investigate Pleistocene uplift west of Aigion, by attempting to date remains of marine terraces and sedimentary sequences by calcareous nannoplankton and U-series analyses. Net uplift initiated recently, due to abandonment of an older rift-bounding fault zone and increase in activity on the presently active, coastal fault zone. This change apparently coincides with an abrupt slow down (or, termination) of secondary fault block tilting within the broader hangingwall block of the older zone, indicated by an angular unconformity that dates in the early part ofMIS10 ( 390–350 ka BP, preferably, in the earlier part of this period). Net uplift driven by the coastal zone resulted in the formation of MIS9c (330 ka) and younger terraces. The formation of the unconformity and the initiation of net uplift coincide temporally with a 300–400 ka unconformity recognized by recent studies in a wide area offshore Aigion i.e. they could be part of an evolutionary event that affected the entirewestern part of the Corinth Rift or, a large area therein. Uplift rate estimates at four locations are discussed with reference to the morphotectonic context of differential uplift of secondary fault blocks, and the context of possible increase in uplift ratewith time. Themost reliable and most useful estimate for uplift rate at the longitude of the studied transect is 1.74–1.85mm/year (time-averaged estimate for the last 240 ka, based on calcareous nannoplankton and sequence-stratigraphic interpretation)
    Description: ‘3HAZ Corinth’ E.U. research project 004043 (GOCE)-3HAZ-Corinth
    Description: Published
    Description: 78 - 104
    Description: 3.2. Tettonica attiva
    Description: JCR Journal
    Description: partially_open
    Keywords: coastal uplift ; marine terraces ; marine sequences ; deformation rate ; Pleistocene ; Corinth Gulf Reef ; 04. Solid Earth::04.04. Geology::04.04.01. Earthquake geology and paleoseismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 12
    Publication Date: 2017-04-04
    Description: The 2011 Tohoku-oki (Mw 9.1) earthquake is so far the best-observed megathrust rupture, which allowed the collection of unprecedented offshore data. The joint inversion of tsunami waveforms (DART buoys, bottom pressure sensors, coastal wave gauges, and GPS-buoys) and static geodetic data (onshore GPS, seafloor displacements obtained by a GPS/acoustic combination technique), allows us to retrieve the slip distribution on a non-planar fault. We show that the inclusion of near-source data is necessary to image the details of slip pattern (maximum slip ,48 m, up to ,35 m close to the Japan trench), which generated the large and shallow seafloor coseismic deformations and the devastating inundation of the Japanese coast. We investigate the relation between the spatial distribution of previously inferred interseismic coupling and coseismic slip and we highlight the importance of seafloor geodetic measurements to constrain the interseismic coupling, which is one of the key-elements for long-term earthquake and tsunami hazard assessment.
    Description: Published
    Description: 385
    Description: 3.1. Fisica dei terremoti
    Description: N/A or not JCR
    Description: restricted
    Keywords: Tohoku ; Subduction ; Tsunami ; Inverse problem ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.07. Tectonophysics::04.07.06. Subduction related processes
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 13
    Publication Date: 2019-07-17
    Description: The mid-Piacenzian climate represents the most geologically recent interval of long-term average warmth relative to the last million years, and shares similarities with the climate projected for the end of the 21st century. As such, it represents a natural experiment from which we can gain insight into potential climate change impacts, enabling more informed policy decisions for mitigation and adaptation. Here, we present the first systematic comparison of Pliocene sea surface temperature (SST) between an ensemble of eight climate model simulations produced as part of PlioMIP (Pliocene Model Intercomparison Project) with the PRISM (Pliocene Research, Interpretation and Synoptic Mapping) Project mean annual SST field. Our results highlight key regional and dynamic situations where there is discord between the palaeoenvironmental reconstruction and the climate model simulations. These differences have led to improved strategies for both experimental design and temporal refinement of the palaeoenvironmental reconstruction.
    Repository Name: EPIC Alfred Wegener Institut
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  • 14
    Publication Date: 2019-07-17
    Description: Comparing simulations of key warm periods in Earth history with contemporaneous geological proxy data is a useful approach for evaluating the ability of climate models to simulate warm, high-CO2 climates that are unprecedented in the more recent past. Here we use a global data set of confidence-assessed, proxy-based temperature estimates and biome reconstructions to assess the ability of eight models to simulate warm terrestrial climates of the Pliocene epoch. The Late Pliocene, 3.6–2.6 million years ago, is an accessible geological interval to understand climate processes of a warmer world. We show that model-predicted surface air temperatures reveal a substantial cold bias in the Northern Hemisphere. Particularly strong data–model mismatches in mean annual temperatures (up to 18 °C) exist in northern Russia. Our model sensitivity tests identify insufficient temporal constraints hampering the accurate configuration of model boundary conditions as an important factor impacting on data–model discrepancies. We conclude that to allow a more robust evaluation of the ability of present climate models to predict warm climates, future Pliocene data–model comparison studies should focus on orbitally defined time slices.
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  • 15
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    Wiley
    In:  EPIC3Geophysical Research Letters, Wiley, 40(22), pp. 5882-5887, ISSN: 0094-8276
    Publication Date: 2019-07-17
    Description: Optical televiewer luminosity logs are compared with densities measured gravimetrically on 520 snow, firn and ice samples from two locations of similar annual temperature (~-14 °C) and contrasting accumulation rates (0.23 and 0.43 m w.e. per year) on the Roi Baudouin Ice Shelf, Antarctica. At the scale of ≥10-1 m, an inverse exponential relationship (R2 = 0.96) is recorded between density and luminosity, indicating (i) that OPTV luminosity provides an effective proxy for density at such ice shelves, and (ii) that densities may be reconstructed from boreholes drilled elsewhere by hot water without the need for core material. Our analysis also suggests that this relationship may hold for newly-formed ice as well as for snow and firn. At the scale of ≤10-1 m, both luminosity and density show similar patterns, but precise correlation is confounded by detailed differences between the two records.
    Repository Name: EPIC Alfred Wegener Institut
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  • 16
    Publication Date: 2014-04-02
    Description: Over the last decade, several hundred seals have been equipped with conductivity-temperature-depth sensors in the Southern Ocean for both biological and physical oceanographic studies. A calibrated collection of seal-derived hydrographic data is now available, consisting of more than 165,000 profiles. The value of these hydrographic data within the existing Southern Ocean observing system is demonstrated herein by conducting two state estimation experiments, differing only in the use or not of seal data to constrain the system. Including seal-derived data substantially modifies the estimated surface mixedlayer properties and circulation patterns within and south of the Antarctic Circumpolar Current. Agreement with independent satellite observations of sea ice concentration is improved, especially along the East Antarctic shelf. Instrumented animals efficiently reduce a critical observational gap, and their contribution to monitoring polar climate variability will continue to grow as data accuracy and spatial coverage increase.
    Repository Name: EPIC Alfred Wegener Institut
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  • 17
    Publication Date: 2017-10-18
    Description: Efforts to extract a Greenland ice core with a complete record of the Eemian interglacial (130,000 to 115,000 years ago) have until now been unsuccessful. The response of the Greenland ice sheet to the warmer-than-present climate of the Eemian has thus remained unclear. Here we present the new North Greenland Eemian Ice Drilling (‘NEEM’) ice core and show only a modest ice-sheet response to the strong warming in the early Eemian. We reconstructed the Eemian record from folded ice using globally homogeneous parameters known from dated Greenland and Antarctic ice-core records. On the basis of water stable isotopes, NEEM surface temperatures after the onset of the Eemian (126,000 years ago) peaked at 8 ± 4 degrees Celsius above the mean of the past millennium, followed by a gradual cooling that was probably driven by the decreasing summer insolation. Between 128,000 and 122,000 years ago, the thickness of the northwest Greenland ice sheet decreased by 400 ± 250 metres, reaching surface elevations 122,000 years ago of 130 ± 300 metres lower than the present. Extensive surface melt occurred at the NEEM site during the Eemian, a phenomenon witnessed when melt layers formed again at NEEM during the exceptional heat of July 2012. With additional warming, surface melt might become more common in the future.
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  • 18
    Publication Date: 2014-12-16
    Description: [1] The Antarctic Intermediate Water (AAIW) is a key player in global-scale oceanic overturning processes and an important conduit for heat, fresh water, and carbon transport. The AAIW past variability is poorly understood mainly due to the lack of sedimentary archives at intermediate water depths. We present records of benthic stable isotopes from sediments retrieved with the seafloor drill rig MARUM-MeBo at 956 m water depth off northern Chile (GeoB15016, 27°29.48′S, 71°07.58′W) that extend back to 970 ka. The sediments at this site are presently deposited at the boundary between AAIW and Pacific Deep Water (PDW). For previous peak interglacials, our results reveal similar benthic δ13C values at site GeoB15016 and of a newly generated stack of benthic δ13C from various deep Pacific cores representing the “average PDW.” This suggests, unlike today, the absence of AAIW at the site and the presence of nearly pure PDW. In contrast, more positive δ13C values at site GeoB15016 compared to the stack imply a considerable AAIW contribution during cold phases of interglacials and especially during glacials. Besides, we used three short sediment cores to reconstruct benthic δ13C values from the AAIW core during the last glacial and found a δ13C signature similar to today's. Assuming that this was the case also for the past 970 kyr, we demonstrate that sea level changes and latitudinal migrations of the AAIW formation site can only account for about 50% of the full range of past δ13C increases at site GeoB15016 during cold periods. Other processes that could explain the remaining of the positive δ13C anomalies are increases in glacial AAIW production and/or deeper convection of the AAIW with respect to preceding interglacials.
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  • 19
    Publication Date: 2014-06-25
    Description: wo commonly used proxies based on the distribution of glycerol dialkyl glycerol tetraethers (GDGTs) are the TEX86 (TetraEther indeX of 86 carbon atoms) paleothermometer for sea surface temperature reconstructions and the BIT (Branched Isoprenoid Tetraether) index for reconstructing soil organic matter input to the ocean. An initial round-robin study of two sediment extracts, in which 15 laboratories participated, showed relatively consistent TEX86 values (reproducibility ±3–4°C when translated to temperature) but a large spread in BIT measurements (reproducibility ±0.41 on a scale of 0–1). Here we report results of a second round-robin study with 35 laboratories in which three sediments, one sediment extract, and two mixtures of pure, isolated GDGTs were analyzed. The results for TEX86 and BIT index showed improvement compared to the previous round-robin study. The reproducibility, indicating interlaboratory variation, of TEX86 values ranged from 1.3 to 3.0°C when translated to temperature. These results are similar to those of other temperature proxies used in paleoceanography. Comparison of the results obtained from one of the three sediments showed that TEX86 and BIT indices are not significantly affected by interlaboratory differences in sediment extraction techniques. BIT values of the sediments and extracts were at the extremes of the index with values close to 0 or 1, and showed good reproducibility (ranging from 0.013 to 0.042). However, the measured BIT values for the two GDGT mixtures, with known molar ratios of crenarchaeol and branched GDGTs, had intermediate BIT values and showed poor reproducibility and a large overestimation of the “true” (i.e., molar-based) BIT index. The latter is likely due to, among other factors, the higher mass spectrometric response of branched GDGTs compared to crenarchaeol, which also varies among mass spectrometers. Correction for this different mass spectrometric response showed a considerable improvement in the reproducibility of BIT index measurements among laboratories, as well as a substantially improved estimation of molar-based BIT values. This suggests that standard mixtures should be used in order to obtain consistent, and molar-based, BIT values.
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  • 20
    Publication Date: 2019-07-16
    Description: Estimates of the relative motion between the Hawaiian and Louisville hot spots have consequences for understanding the role and character of deep Pacific-mantle return flow. The relative motion between these primary hot spots can be inferred by comparing the age records for their seamount trails. We report 40Ar/39Ar ages for 18 lavas from 10 seamounts along the Hawaiian-Emperor Seamount Chain (HESC), showing that volcanism started in the sharp portion of the Hawaiian-Emperor Bend (HEB) at ≥47.5 Ma and continued for ≥5 Myr. The slope of the along-track distance from the currently active Hawaiian hot spot plotted versus age is constant (57 ± 2 km/Myr) between ∼57 and 25 Ma in the central ∼1900 km of the seamount chain, including the HEB. This model predicts an age for the oldest Emperor Seamounts that matches published ages, implying that a linear age-distance relationship might extend back to at least 82 Ma. In contrast, Hawaiian age progression was much faster since at least ∼15 Ma and possibly as early as ∼27 Ma. Linear age-distance relations for the Hawaii-Emperor and Louisville seamount chains predict ∼300 km overall hot spot relative motion between 80 and 47.5 Ma, in broad agreement with numerical models of plumes in a convecting mantle, and paleomagnetic data. We show that a change in hot spot relative motion may also have occurred between ∼55 Ma and ∼50 Ma. We interpret this change in hot spot motion as evidence that the HEB reflects a combination of hot spot and plate motion changes driven by the same plate/mantle reorganization.
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  • 21
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    Wiley
    In:  EPIC3Geophysical Research Letters, Wiley, 40(21), pp. 5735-5739, ISSN: 0094-8276
    Publication Date: 2019-07-16
    Description: The western Ross Sea is one of the key sites for cross-shelf water exchange around Antarctica. The mech- anism through which tides affect the cross-shelf exchange in the northwestern Ross Sea is investigated using numeri- cal simulations. Tides are found to increase the high-salinity shelf water (HSSW) outflow through the impact on the warm water intrusion of open ocean origin. The residual tidal currents are onshore along the Modified Circumpolar Deep Water pathway and therefore enhance its intrusion. Lighter ambient water adjacent to the HSSW increases the cross-flow density gradient, thus strengthening the HSSW export. At the same time, the onshore residual current and increased dilution of the HSSW have the potential to reduce the export rate. Owing to the existence of opposite tidal effects, the strongest HSSW export happens at the inter- mediate tidal forcing strength. The amplification of tides on cross-shelf exchange indicates that the relevant dynam- ical processes should be simulated or parameterized in climate models in order to adequately predict the ocean.
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  • 22
    Publication Date: 2019-07-17
    Description: We present a climatology of the diurnal variation of short-lived atmospheric compounds, such as ClO, BrO, HO2, and HOCl, as well as longer-lived species: O3, the hydrogen chloride isotopes H35Cl and H37Cl, and HNO3. Measurements were taken by the Superconducting Submillimeter-wave Limb-Emission Sounder (SMILES). This spectrally resolving radiometer, with very low observation noise and altitude range from the lower stratosphere to the lower thermosphere (20–100km), was measuring vertical profiles of absorption spectra along a non-sun-synchronous orbit, thus observing at all local times. We used the retrieved volume mixing ratio profiles to compile climatologies that are a function of pressure, a horizontal coordinate (latitude or equivalent latitude), and a temporal coordinate (solar zenith angle or local solar time). The main product presented are climatologies with a high resolution of the temporal coordinate (diurnal variation climatologies). In addition, we provide climatologies with a high resolution of the horizontal coordinate (zonal climatologies).The diurnal variation climatologies are based on data periods of 2 months and the zonal climatologies on monthly data periods. Consideration of the SMILES time-space sampling patterns with respect to the averaging coordinates is a key issue for climatology creation, especially in case of diurnal variation climatologies. Biases induced by inhomogeneous sampling are minimized by carefully choosing the size of averaging bins. The sampling biases of the diurnal variation climatology of ClO and BrO are investigated in a comparison of homogeneously sampled model data versus SMILES-sampled model data from the stratospheric Lagrangian chemistry and transport model ATLAS. In most cases, the relative sampling error is in the range of 0–20%. The strongest impact of sampling biases is found where the species' temporal gradients are strongest (mostly at sunrise and sunset), with a relative error of 60–100%. The SMILES climatology data sets are available via the SMILES data distribution home page.
    Repository Name: EPIC Alfred Wegener Institut
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  • 23
    Publication Date: 2014-11-28
    Description: We explore the impact of a latitudinal shift in the westerly wind belt over the Southern Ocean on the Atlantic meridional overturning circulation (AMOC) and on the carbon cycle for Last Glacial Maximum background conditions using a state-of-the-art ocean general circulation model. We find that a southward (northward) shift in the westerly winds leads to an intensification (weakening) of no more than 10% of the AMOC. This response of the ocean physics to shifting winds agrees with other studies starting from pre-industrial background climate, but the responsible processes are different. In our setup changes in AMOC seemed to be more pulled by upwelling in the south than pushed by down-welling in the north, opposite to what previous studies with different background climate are suggesting. The net effects of the changes in ocean circulation lead to a rise in atmospheric pCO2 of less than 10 μatm for both a northward and a southward shift in the winds. For northward shifted winds the zone of upwelling of carbon and nutrient rich waters in the Southern Ocean is expanded, leading to more CO2 out-gassing to the atmosphere but also to an enhanced biological pump in the subpolar region. For southward shifted winds the upwelling region contracts around Antarctica leading to less nutrient export northwards and thus a weakening of the biological pump. These model results do not support the idea that shifts in the westerly wind belt play a dominant role in coupling atmospheric CO2 rise and Antarctic temperature during deglaciation suggested by the ice core data.
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  • 24
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    Wiley
    In:  EPIC3Journal of Geophysical Research: Atmospheres, Wiley, 118(14), pp. 7698-7714, ISSN: 2169-8996
    Publication Date: 2014-06-06
    Description: The coupled regional climate model HIRHAM-NAOSIM is used to investigate feedbacks between September sea ice anomalies in the Arctic and atmospheric conditions in autumn and the subsequent winter. A six-member ensemble of simulations spanning the period 1949–2008 is analyzed. The results show that negative Arctic sea ice anomalies are associated with increased heat and moisture fluxes, decreased static stability, increased lower tropospheric moisture, and modified baroclinicity, synoptic activity, and atmospheric large-scale circulation. The circulation changes in the following winter display meridionalized flow but are not fully characteristic of a negative Arctic Oscillation pattern, though they do support cold winter temperatures in northern Eurasia. Internally generated climate variability causes significant uncertainty in the simulated circulation changes due to sea ice-atmosphere interactions. The simulated atmospheric feedback patterns depend strongly on the position and strength of the regional sea ice anomalies and on the analyzed time period. The strongest atmospheric feedbacks are related to sea ice anomalies in the Beaufort Sea. This work suggests that there are complex feedback mechanisms that support a statistical link between reduced September sea ice and Arctic winter circulation. However, the feedbacks depend on regional and decadal variations in the coupled atmosphere-ocean-sea ice system.
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  • 25
    Publication Date: 2017-06-27
    Description: Paleoceanographic archives derived from 17 marine sediment cores reconstruct the response of the Southwest Pacific Ocean to the peak interglacial, Marine Isotope Stage (MIS) 5e (ca. 125 ka). Paleo-Sea Surface Temperature (SST) estimates were obtained from the Random Forest model—an ensemble decision tree tool—applied to core-top planktonic foraminiferal faunas calibrated to modern SSTs. The reconstructed geographic pattern of the SST anomaly (maximum SST between 120 and 132 ka minus mean modern SST) seems to indicate how MIS 5e conditions were generally warmer in the Southwest Pacific, especially in the western Tasman Sea where a strengthened East Australian Current (EAC) likely extended subtropical influence to ca. 45°S off Tasmania. In contrast, the eastern Tasman Sea may have had a modest cooling except around 45°S. The observed pattern resembles that developing under the present warming trend in the region. An increase in wind stress curl over the modern South Pacific is hypothesized to have spun-up the South Pacific Subtropical Gyre, with concurrent increase in subtropical flow in the western boundary currents that include the EAC. However, warmer temperatures along the Subtropical Front and Campbell Plateau to the south suggest that the relative influence of the boundary inflows to eastern New Zealand may have differed in MIS 5e, and these currents may have followed different paths compared to today.
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  • 26
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    Wiley
    In:  EPIC3Journal of Geophysical Research-Earth Surface, Wiley, 118(2), pp. 693-705, ISSN: 0148-0227
    Publication Date: 2017-05-29
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  • 27
    Publication Date: 2022-05-25
    Description: © Macmillan Publishers Limited, 2010. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. The definitive version was published in Nature Communications 1 (2010): 49, doi:10.1038/ncomms1045.
    Description: Motor innervation to the tetrapod forelimb and fish pectoral fin is assumed to share a conserved spinal cord origin, despite major structural and functional innovations of the appendage during the vertebrate water-to-land transition. In this paper, we present anatomical and embryological evidence showing that pectoral motoneurons also originate in the hindbrain among ray-finned fish. New and previous data for lobe-finned fish, a group that includes tetrapods, and more basal cartilaginous fish showed pectoral innervation that was consistent with a hindbrain-spinal origin of motoneurons. Together, these findings support a hindbrain–spinal phenotype as the ancestral vertebrate condition that originated as a postural adaptation for pectoral control of head orientation. A phylogenetic analysis indicated that Hox gene modules were shared in fish and tetrapod pectoral systems. We propose that evolutionary shifts in Hox gene expression along the body axis provided a transcriptional mechanism allowing eventual decoupling of pectoral motoneurons from the hindbrain much like their target appendage gained independence from the head.
    Description: Th is work was supported by the National Institutes of Health and National Science Foundation.
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  • 28
    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 3 (2013): 2802, doi:10.1038/srep02802.
    Description: It is usually assumed that metabolic constraints restrict deep-sea corals to cold-water habitats, with ‘deep-sea’ and ‘cold-water’ corals often used as synonymous. Here we report on the first measurements of biological characters of deep-sea corals from the central Red Sea, where they occur at temperatures exceeding 20°C in highly oligotrophic and oxygen-limited waters. Low respiration rates, low calcification rates, and minimized tissue cover indicate that a reduced metabolism is one of the key adaptations to prevailing environmental conditions. We investigated four sites and encountered six species of which at least two appear to be undescribed. One species is previously reported from the Red Sea but occurs in deep cold waters outside the Red Sea raising interesting questions about presumed environmental constraints for other deep-sea corals. Our findings suggest that the present understanding of deep-sea coral persistence and resilience needs to be revisited.
    Keywords: Ecosystem ecology ; Biodiversity ; Genetics ; Metabolism
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  • 29
    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 496 (2013): 311-316, doi:10.1038/nature12027.
    Description: The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.
    Description: cquisition and storage of Latimeria chalumnae samples was supported by grants from the African Coelacanth Ecosystem Programme of the South African National Department of Science and Technology. Generation of the Latimeria chalumnae and Protopterus annectens sequences by the Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard University was supported by grants from the National Human Genome Research Institute (NHGRI). K.L.T. is the recipient of a EURYI award from the European Science Foundation.
    Keywords: Genome evolution ; Comparative genomics
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  • 30
    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 499 (2013): 209–213, doi:10.1038/nature12221.
    Description: Coccolithophores have influenced the global climate for over 200 million years1. These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems2. They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space3. Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean4. Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
    Description: Joint Genome Institute (JGI) contributions were supported by the Office of Science of the US Department of Energy (DOE) under contract no. 7DE-AC02-05CH11231.
    Keywords: Genetic variation
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  • 31
    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 499 (2013): 431–437, doi:10.1038/nature12352.
    Description: Genome sequencing enhances our understanding of the biological world by providing blueprints for the evolutionary and functional diversity that shapes the biosphere. However, microbial genomes that are currently available are of limited phylogenetic breadth, owing to our historical inability to cultivate most microorganisms in the laboratory. We apply single-cell genomics to target and sequence 201 uncultivated archaeal and bacterial cells from nine diverse habitats belonging to 29 major mostly uncharted branches of the tree of life, so-called ‘microbial dark matter’. With this additional genomic information, we are able to resolve many intra- and inter-phylum-level relationships and to propose two new superphyla. We uncover unexpected metabolic features that extend our understanding of biology and challenge established boundaries between the three domains of life. These include a novel amino acid use for the opal stop codon, an archaeal-type purine synthesis in Bacteria and complete sigma factors in Archaea similar to those in Bacteria. The single-cell genomes also served to phylogenetically anchor up to 20% of metagenomic reads in some habitats, facilitating organism-level interpretation of ecosystem function. This study greatly expands the genomic representation of the tree of life and provides a systematic step towards a better understanding of biological evolution on our planet.
    Description: The work conducted by the US Department of Energy Joint Genome Institute is supported by the Office of Science of the US Department of Energy under Contract No. DE-AC02-05CH11231. We also thank the CeBiTec Bioinformatics Resource Facility, which is supported byBMBF grant 031A190. B.P.H. and J.A.D. were supported by the NASA Exobiology grant EXO-NNX11AR78GandNSFOISE 096842and B.P.H. by a generous contribution from G. Fullmer through the UNLV Foundation. S.M.S was supported by NSF grants OCE-0452333 and OCE-1136727, and the WHOI’s Andrew W. Mellon Fund for Innovative Research; and S.J.H. by the Canadian Foundation for Innovation, the British Columbia Knowledge Development Fund, the National Sciences and Engineering Research Council (NSERC) of Canada and the TULA foundation funded Centre for Microbial Diversity and Evolution (CMDE), and the Canadian Institute for Advanced Research (CIFAR). R.S. was supported by NSF grants DEB-841933, EF-826924, OCE-1232982, OCE-821374 and OCE-1136488, and the Deep Life I grant by the Alfred P. Sloan Foundation. P.H.was supported by a Discovery Outstanding Researcher Award (DORA) from the Australian Research Council, grant DP120103498.
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  • 32
    Publication Date: 2022-05-26
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 500 (2013): 453–457, doi:10.1038/nature12326.
    Description: Loss of sexual reproduction is considered an evolutionary dead end for metazoans, but bdelloid rotifers challenge this view as they appear to have persisted asexually for millions of years1. Neither male sex organs nor meiosis have ever been observed in these microscopic animals: oocytes are formed through mitotic divisions, with no reduction of chromosome number and no indication of chromosome pairing2. However, current evidence does not exclude that they may engage in sex on rare, cryptic occasions. Here we report the genome of a bdelloid rotifer, Adineta vaga (Davis, 1873)3, and show that its structure is incompatible with conventional meiosis. At gene scale, the genome of A. vaga is tetraploid and comprises both anciently duplicated segments and less divergent allelic regions. However, in contrast to sexual species, the allelic regions are rearranged and sometimes even found on the same chromosome. Such structure does not allow meiotic pairing; instead, we find abundant evidence of gene conversion, which may limit the accumulation of deleterious mutations in the absence of meiosis. Gene families involved in resistance to oxidation, carbohydrate metabolism and defence against transposons are significantly expanded, which may explain why transposable elements cover only 3% of the assembled sequence. Furthermore, 8% of the genes are likely to be of non-metazoan origin and were probably acquired horizontally. This apparent convergence between bdelloids and prokaryotes sheds new light on the evolutionary significance of sex.
    Description: This work was supported by Genoscope-CES (where most of the sequencing was performed), by US National Science Foundation grants MCB-0821956 and MCB-1121334 to I.A., by German Research Foundation grant HA 5163/2-1 to O.H., by grant 11.G34.31.0008 fromthe Ministry of Education and Science of the Russian Federation to A.S.K., by grant NSF CAREER number 0644282 to M.K., by US National Science Foundation grant MCB-0923676 to D.B.M.W., by FRFC grant 2.4.655.09.F from the Belgian Fonds National de la Recherche Scientifique (FNRS) and a start-up grant from the University of Namur to K.V.D.; J.F.F. and K.V.D. thank also J.-P. Descy (University of Namur) for funding support.
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  • 33
    Publication Date: 2022-05-26
    Description: © Macmillan Publishers, 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Oncogene 32 (2013): 1135–1143, doi:10.1038/onc.2012.135.
    Description: Neurofibromatosis type 2 patients develop schwannomas, meningiomas and ependymomas resulting from mutations in the tumor suppressor gene, NF2, encoding a membrane-cytoskeleton adapter protein called merlin. Merlin regulates contact inhibition of growth and controls the availability of growth factor receptors at the cell surface. We tested if microtubule-based vesicular trafficking might be a mechanism by which merlin acts. We found that schwannoma cells, containing merlin mutations and constitutive activation of the Rho/Rac family of GTPases, had decreased intracellular vesicular trafficking relative to normal human Schwann cells. In Nf2−/− mouse Schwann (SC4) cells, re-expression of merlin as well as inhibition of Rac or its effector kinases, MLK and p38SAPK, each increased the velocity of Rab6 positive exocytic vesicles. Conversely, an activated Rac mutant decreased Rab6 vesicle velocity. Vesicle motility assays in isolated squid axoplasm further demonstrated that both mutant merlin and active Rac specifically reduce anterograde microtubule-based transport of vesicles dependent upon the activity of p38SAPK kinase. Taken together, our data suggest loss of merlin results in the Rac-dependent decrease of anterograde trafficking of exocytic vesicles, representing a possible mechanism controlling the concentration of growth factor receptors at the cell surface.
    Description: This work was supported by NIH R01 CA118032 (to NR), and MBL research fellowships (to NR and GM), NIH R01 NS23868 (to STB).
    Keywords: Merlin ; NF2 ; Rac ; Trafficking ; Exocytosis
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  • 34
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    Nature medicine 13 (2007), S. 1-1 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] In the future, Nature Medicine will be famous to 15 ...
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  • 35
    ISSN: 1546-170X
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    Notes: [Auszug] TH17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions ...
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    Nature medicine 13 (2007), S. 13-13 
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    Notes: [Auszug] To the editor: The recent article by Kerkelä et al. reported clinical findings of congestive heart failure (CHF) in ten patients, and preclinical studies showing that imatinib-treated mice can develop left ventricular contractile dysfunction and cellular abnormalities suggestive of a toxic ...
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    Nature medicine 13 (2007), S. 14-14 
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    Notes: [Auszug] To the editor: We read with interest the article of Kerkelä et al. discussing the potential cardiotoxicity of imatinib mesylate in animal models and detailing ten patients, nine from our institution, who developed congestive heart failure (CHF) on imatinib therapy. This report has generated ...
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    Nature medicine 13 (2007), S. 17-18 
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    Notes: [Auszug] To the Editor: Binding between C-reactive protein (CRP) and human leptin in vitro, and inhibition by CRP of the effects of human leptin in mice in vivo, have recently been reported by Chen et al.. In their in vitro studies the authors showed that after exposure of leptin-coupled agarose beads to ...
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  • 39
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    Nature medicine 13 (2007), S. 649-649 
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    Topics: Biology , Medicine
    Notes: [Auszug] The issue of aging academics in times of budgetary constraints has stirred vigorous debate. Many older professors continue to be productive researchers and inspiring teachers with plenty of wind in their sails. However, some say the abundance of older professors is clogging an already narrow ...
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    Nature medicine 13 (2007), S. 652-652 
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    Notes: [Auszug] Did you wear a thick, blue plastic bracelet with the words “I decline the Northfield PolyHeme study” splashed across it in bold black writing during the years 2004 to 2006?... If not, and had you been in a serious accident during that time, you could have been unwittingly enrolled in a ...
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    Nature medicine 13 (2007), S. 651-651 
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    Notes: [Auszug] In the fight against malaria, long-lasting insecticidal bed nets—made from polyester or plastic and treated with insecticides—are a favorite tool. Because they can be washed and reused for years, donors such as the Roll Back Malaria Partnership push for their use.... But the nets are ...
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    Notes: [Auszug] British doctors have begun collecting samples for Britain's first storehouse of infectious diseases, two years after the launch of the UK's ambitious BioBank project.... Following nearly a year of discussion over ethical approval, Guy’s & St Thomas’ hospital in London has a £45 million ...
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  • 43
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    Notes: [Auszug] Interstitial loss of all or part of the long arm of chromosome 5, or del(5q), is a frequent clonal chromosomal abnormality in human myelodysplastic syndrome (MDS, a preleukemic disorder) and acute myeloid leukemia (AML), and is thought to contribute to the pathogenesis of these diseases by deleting ...
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    Notes: [Auszug] Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial ...
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    Notes: [Auszug] Here's how doctors decide which mental or neurological disorder their troubled patients suffer from: they ask questions like, “Are you hearing voices?” and “Do you feel like people are out to get you?”... Not all that different from how they used to do it about 100 years ...
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    Notes: [Auszug] Findings by Obeid et al. in this issue highlight a way to potentially enhance the ability of the immune system to kill tumor cells. The authors suggest that how cells die during chemotherapy is critical; one set of chemotherapeutic agents in particular, anthracyclins, seem to foster a favorable ...
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  • 47
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    Notes: [Auszug] Nur77 (NR4A1) and Nor-1 (NR4A3) are highly homologous orphan nuclear receptors that regulate the transcription of overlapping target genes. The transcriptional activity of both proteins is regulated in a ligand-independent manner by cell- and stimulus-specific gene induction and protein ...
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  • 48
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    Notes: [Auszug] Exotoxins of Staphylococcus aureus belong to a family of bacterial proteins that act as superantigens by activating a large subset of the T-cell population, causing massive release of inflammatory cytokines. This cascade can ultimately result in toxic shock syndrome and death. Therapeutics ...
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    ISSN: 1546-170X
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    Notes: [Auszug] T-helper type 17 cells (TH17) are implicated in rodent models of immune-mediated diseases. Here we report their involvement in human uveitis and scleritis, and validate our findings in experimental autoimmune uveoretinitis (EAU), a model of uveitis. TH17 cells were present in human peripheral blood ...
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    ISSN: 1546-170X
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    Notes: [Auszug] The metabolism of vitamin A and the diverse effects of its metabolites are tightly controlled by distinct retinoid-generating enzymes, retinoid-binding proteins and retinoid-activated nuclear receptors. Retinoic acid regulates differentiation and metabolism by activating the retinoic acid receptor ...
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    Notes: [Auszug] Soldier's son, wife develop rare case of eczema ...
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    Nature medicine 13 (2007), S. 522-523 
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    Notes: [Auszug] In the ongoing battle between bacteria and antibiotics, strains of Staphylococcus aureus are emerging the winners, reports Douglas ...
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    Nature medicine 13 (2007), S. 524-524 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] How good is the new prostate cancer ...
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    Nature medicine 13 (2007), S. 520-521 
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    Notes: [Auszug] 19 Mar A group of nine prominent American scientific institutions call for an increase in funding for the US National Institutes of Health, warning that stagnant budgets outpaced by inflation threaten the progress of biomedical research.... 19 Mar Mosquitoes modified to carry a gene that ...
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    Nature medicine 13 (2007), S. 527-528 
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    Notes: [Auszug] To the editor: Adult T-cell leukemia/lymphoma (ATLL) is a fatal T-cell neoplasm caused by infection with human T-cell leukemia virus type I (HTLV-I). Hasegawa et al. have described transgenic mice that express HTLV-I Tax viral regulatory protein/oncoprotein in thymocytes. These mice developed ...
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    Nature medicine 13 (2007), S. 534-536 
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    Notes: [Auszug] Until recently, only 5–10% of autism cases were traceable to an underlying genetic cause. Two studies now change this. Jacquemont et al. and Sebat et al. suggest that this number is actually 10–20%, and it may grow to 30–40% with further research. The advance is based primarily on ...
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    Nature medicine 13 (2007), S. 538-539 
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    Notes: [Auszug] This year marks the twentieth anniversary of the discovery of the dystrophin gene, which is mutated in the devastating X-linked recessive muscle disease Duchenne muscular dystrophy (DMD). During DMD, heart and skeletal muscles break down, so that the affected boys are typically wheelchair-bound by ...
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    Nature medicine 13 (2007), S. 536-538 
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    Notes: [Auszug] The key immunological regulator osteopontin was first identified as a structural protein in bone that formed a bridge (Latin pons) between the bone's mineral matrix and the bone cells inside it. Later, expression of osteopontin by activated T cells and dendritic cells was found to be an essential ...
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    Nature medicine 13 (2007), S. 539-541 
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    Notes: [Auszug] Heart failure is a common and lethal condition, yet why the heart muscle fails remains a mystery. Alterations in myocardial metabolism, defects in calcium handling, alterations in myosin isoforms, cytoskeletal abnormalities and excessive cardiac myocyte apoptosis have all been implicated as causal ...
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    Nature medicine 13 (2007), S. 541-541 
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    Notes: [Auszug] How microRNAs (miRNAs) influence heart development and disease is a topic of growing interest. miRNAs regulate gene expression post-transcriptionally, typically by binding to mRNAs and inhibiting their translation. Three recent papers show that miRNAs are essential for heart development and ...
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    Nature medicine 13 (2007), S. 542-542 
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    Notes: [Auszug] Gender matters How infertility-causing mutations are inherited is a tough puzzle. A dominant mutation with sex-specific phenotypes provides a clue (PLoS, doi:10.1371/journal.pbio.0050105). In screening mice for infertility, Laura Bannister et al. isolated a male sterile allele of ...
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    Notes: [Auszug] Human embryonic stem cells (hESCs) are a promising source for cell therapy in degenerative diseases. A key step in establishing the medical potential of hESCs is the development of techniques for the conversion of hESCs into tissue-restricted precursors suitable for transplantation. We recently ...
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    Notes: [Auszug] The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated uropathogenic Escherichia coli (UPEC) ...
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    Notes: [Auszug] During physical exercise, increases in motor neuron activity stimulate the expression of muscle-specific genes through the myocyte enhancer factor 2 (MEF2) family of transcription factors. Elevations in intracellular calcium increase MEF2 activity via the phosphorylation-dependent inactivation of ...
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    Nature medicine 13 (2007), S. 392-393 
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    Notes: [Auszug] When Gardasil, the first vaccine against human papilloma virus (HPV), was approved in June 2006 by the US Food and Drug Administration, it was widely hailed as a godsend for women.... Clinical trials involving more than 20,000 women showed the vaccine to be safe and effective. But the vaccine's ...
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    Nature medicine 13 (2007), S. 393-393 
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    Notes: [Auszug] The average doctor's office these days looks much like a pharmaceutical sales convention: patients wipe their noses with Lipitor tissues and sign forms with Boniva pens attached to Lunesta clipboards. The ubiquity of these drug ads—and the sales representatives that place them—is ...
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    Notes: [Auszug] Cbl-associated protein (Cap) is a member of a phosphatidylinositol 3-kinase–independent pathway for insulin-stimulated translocation of the glucose transporter GLUT4. Despite this positive role of Cap in glucose uptake, here we show that deletion of the gene encoding Cap (official gene name: ...
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    Notes: [Auszug] The germinal matrix of premature infants is selectively vulnerable to hemorrhage within the first 48 h of life. To assess the role of vascular immaturity in germinal matrix hemorrhage (GMH), we evaluated germinal matrix angiogenesis in human fetuses and premature infants, as well as in premature ...
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    Nature medicine 13 (2007), S. 234-235 
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    Notes: [Auszug] 22 Jan Hoping to raise flagging employee morale, the US Centers for Disease Control and Prevention will hire a full-time ombudsman, agency director Julie Gerberding announces. 24 Jan The first draft of the human 'metabolome' describes more than 2,500 metabolites found in the body, of which fewer ...
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    Nature medicine 13 (2007), S. 239-239 
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    Notes: [Auszug] In the history many of us are taught, the fates of societies are determined almost exclusively by the acts of humans, and then primarily humans bearing at least one Y chromosome. In The Power of Plagues, Irwin Sherman challenges this perspective. In the tradition of the Hans Zinsser's 1935 Rats, ...
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    Nature medicine 13 (2007), S. 245-246 
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    Notes: [Auszug] Paul Langerhans, a German medical student, was 21 when he described in 1868 a new epidermal cell type which now bears his name. The cells have long dendrites, so Langerhans regarded them as a component of the nervous system. A century later, Inga Silberberg discovered that these cells instead have ...
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    Nature medicine 13 (2007), S. 242-244 
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    Notes: [Auszug] Recent research has led to a shift in thinking about the pathology of Crohn disease, in which chronic inflammation damages the gastrointestinal track. This paradigm shift highlights a key role for the interleukin (IL)-23 cytokine, rather than the previous emphasis on IL-12, as the driving force ...
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    Nature medicine 13 (2007), S. 246-248 
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    Notes: [Auszug] G protein–coupled receptors (GPCRs) are the largest superfamily of receptors in the human genome. These cell surface receptors transduce signals of an amazing diversity: vision, smell, central and peripheral neurotransmission, and a host of hormone, autocrine and paracrine actions regulating ...
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    Nature medicine 13 (2007), S. 248-250 
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    Notes: [Auszug] Can a vaccine be 'too efficient'? Can it provide such a strong stimulus to the immune system that the response is ultimately abortive rather than productive? In this issue, Berner et al. use mouse models to show that a widely heralded approach to vaccine adjuvants, targeting of the CD40 receptor, ...
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    Nature medicine 13 (2007), S. 250-253 
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    Notes: [Auszug] Tregs play essential roles in immune homeostasis and protection against autoimmunity, but also contribute to immunopathology in cancers, infections and other diseases. The recent discovery that the nuclear transcription factor forkhead box P3 (Foxp3) appeared necessary and sufficient for Treg ...
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    Nature medicine 13 (2007), S. 253-254 
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    Notes: [Auszug] Pneumonic plague is one of the most feared infectious diseases, but it is only recently that progress has been made in understanding the molecular interplay between pathogen and host during the disease. A recent study by Lathem et al. in Science shows that plasminogen activator (Pla), a surface ...
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    Nature medicine 13 (2007), S. 269-269 
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    Notes: [Auszug] For more than a decade, the World Health Organization (WHO) has relied on Direct Observed Therapy Short-course, or DOTS, to fight tuberculosis (TB)—and for nearly as long, the strategy has been controversial.... The idea behind DOTS is that a healthcare worker should directly observe those ...
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    Nature medicine 13 (2007), S. 270-270 
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    Notes: [Auszug] For a liberal arts graduate with no formal science background, Mark Harrington has a lot of influence on research for AIDS and tuberculosis (TB).... The head of the New York–based activist organization Treatment Action Group (TAG), Harrington commands respect from even the most senior AIDS ...
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    Nature medicine 13 (2007), S. 271-271 
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    Notes: [Auszug] Ken Duncan began the year with a new job to fight an old foe.... In January, he became a senior program officer for the Bill & Melinda Gates Foundation's tuberculosis (TB) program, where his job will be to shepherd the development of new drugs for the disease. Duncan's main goal is to help ...
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    Nature medicine 13 (2007), S. 271-271 
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    Notes: [Auszug] Like something out of a horror movie, a lethal strain of tuberculosis blazed in 2005 across Tugela Ferry, a small village in South Africa, striking down nearly everyone it touched.... The strain, dubbed XDR for extensively drug-resistant, doesn't respond to known TB drugs and killed 52 of 53 ...
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    Nature medicine 13 (2007), S. 274-274 
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    Notes: [Auszug] The best hope of eradicating tuberculosis (TB) is to prevent it with mass vaccination. Trouble is, those vaccines don't exist—at least, not yet. The World Health Organization (WHO) has set a goal for a new vaccine by 2015. That may be a bit ambitious: scientists are still trying to pin down ...
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    Nature medicine 13 (2007), S. 275-275 
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    Notes: [Auszug] In January, Médecins Sans Frontières hosted a two-day symposium in New York on tuberculosis (TB). The speakers were much like those at most scientific meetings—a long list of men, most of them from the US or Europe, speaking in lofty terms about big-picture goals.... Then came ...
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    Nature medicine 13 (2007), S. 276-277 
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    Notes: [Auszug] Which papers have provided the most interesting recent advances in tuberculosis research? Which new discoveries in pathogenesis, epidemiology, drug discovery or vaccine development have been the most important or are likely to have the highest impact to the ...
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    Nature medicine 13 (2007), S. 279-280 
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    Notes: [Auszug] Poor William Stewart. This former US Surgeon General is unfairly credited with stating in 1967 that it was “time to close the book on infectious disease.” Although it appears that he never said such a thing, the sentiment was certainly widely shared. For the past several decades, while ...
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    Nature medicine 13 (2007), S. 278-278 
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    Notes: [Auszug] The following tables show the primary research papers on tuberculosis published between 2003 and 2005 that have had the highest number of citations in the literature. To create these tables, we queried the Scopus database (http://www.scopus.com) to search for articles that included the term ...
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    Nature medicine 13 (2007), S. 280-282 
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    Notes: [Auszug] The worldwide mortality and morbidity due to tuberculosis remains excessive despite the availability of drugs that can stably cure it. Multiple factors underlie this paradox. One is treatment duration: regimens of multiple drugs that need to be taken for at least six months without interruption ...
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    Nature medicine 13 (2007), S. 282-284 
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    Notes: [Auszug] Macrophages are phagocytes at the frontline of host immune defense against microbial pathogens. They are also the primary habitat of Mycobacterium tuberculosis: unlike bacteria that dependent on the avoidance of phagocytosis to survive, M. tuberculosis preferentially targets macrophage vacuoles. ...
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    Nature medicine 13 (2007), S. 288-289 
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    Notes: [Auszug] Meet the family From an evolutionary perspective, Mycobacterium tuberculosis and its close relatives are so similar that they seem to have separated from a common ancestor only 20,000–35,000 years ago. What happened before this separation? A 2005 paper by Cristina Gutierrez et al. has ...
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    Nature medicine 13 (2007), S. 284-285 
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    Notes: [Auszug] Lipids have long been thought to play key roles in the pathogenesis of Mycobacterium tuberculosis. In early studies, Segal and Bloch found fatty acids rather than carbohydrates to stimulate respiration of M. tuberculosis if the bacteria were isolated from mouse lungs instead of liquid cultures. In ...
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    Nature medicine 13 (2007), S. 286-287 
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    Notes: [Auszug] Since its introduction as a public health intervention in 1921, vaccination with Bacillus Calmette-Guérin (BCG) has a long and controversial history. As a tool to study the pathogenesis of tuberculosis, BCG has a much shorter, but no less interesting, history. Despite its excellent safety ...
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    Nature medicine 13 (2007), S. 290-294 
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    Notes: [Auszug] The present decade has seen a reawakening of tuberculosis (TB) drug research and development (R&D), spurred on by an urgent need to stem the tide of the disease globally and develop new, more effective treatments against drug-sensitive and resistant strains. As a result, there are now seven ...
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    Nature medicine 13 (2007), S. 295-298 
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    Notes: [Auszug] Extensively drug-resistant tuberculosis (XDR-TB) occurs where health systems have been historically weak; it lays bare the reality of TB as a serious public health problem, especially in areas of high HIV prevalence, and reinforces the need for effective TB control strategies that are coordinated ...
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    Nature medicine 13 (2007), S. 299-303 
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    Notes: [Auszug] Exactly 125 years after the discovery of the etiological agent of tuberculosis (TB), the disease remains as threatening as ever. The insufficient control measures in place today were developed in the late nineteenth and early twentieth centuries. A research and development gap in the latter half of ...
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    Nature medicine 13 (2007), S. 304-308 
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    Notes: [Auszug] How can we make vaccines and medicines for major diseases that have been largely ignored? How can we get vaccines and medicines to populations that cannot afford them? A fundamental solution to these problems requires aligning three basic processes—innovation, incentive and access—so ...
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    Nature medicine 13 (2007), S. 385-385 
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    Notes: [Auszug] Nature Med. 13, 139–145 (2007); published online 6 February 2007; corrected after print 21 February 2007. In the version of this article initially published, the labeling in Figure 1 is incorrect. Tregs should be shown as producing TGF-β, not IL-17. The error has been corrected in the ...
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    Nature medicine 13 (2007), S. 385-385 
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    Notes: [Auszug] Nature Medicine 12, 1259–1268 (2006); published online 22 October 2006. In page 1264 of this article, it is stated that “The donor cells were dispersed over an average radius of 1.6 ± 0.6 mm, and the mean number of HNA+ nuclei/mm3 within each was 136,726 ± 23,515”. ...
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    Nature medicine 13 (2007), S. 309-312 
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    Notes: [Auszug] Historically, tuberculosis (TB) has fallen firmly in the group of 'neglected diseases'—diseases in which pharmaceutical companies have been reluctant to invest due to a perception of low commercial potential. According to the World Health Organization (WHO), an estimated 1.7 million deaths ...
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    Nature medicine 13 (2007), S. 372-377 
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    Notes: [Auszug] With the increased potential of RNA interference (RNAi) as a therapeutic strategy, new noninvasive methods for detection of siRNA delivery and silencing are urgently needed. Here we describe the development of dual-purpose probes for in vivo transfer of siRNA and the simultaneous imaging of its ...
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    Notes: [Auszug] Transmissibility of characteristic lesions to experimental animals may help us understand the pathomechanism of human autoimmune disease. Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious ...
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    Notes: [Auszug] Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN). However, the epithelial Langerhans cells ...
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