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  • Articles  (316)
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  • 2005-2009
  • 2000-2004  (316)
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-23
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907122/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907122/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Falke, Joseph J -- R01 GM040731/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 22;295(5559):1480-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biophysics Program and the Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA. falke@colorado.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11859184" target="_blank"〉PubMed〈/a〉
    Keywords: Arginine/chemistry ; Binding Sites ; Catalysis ; Cyclophilin A/*chemistry/*metabolism ; Hydrogen Bonding ; Models, Molecular ; Nitrogen/chemistry ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Thermodynamics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogelstein, Bert -- Alberts, Bruce -- Shine, Kenneth -- New York, N.Y. -- Science. 2002 Feb 15;295(5558):1237.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Kimmel Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA. vogelbe@welch.jhu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11847324" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethical Issues ; Cell Line ; *Cloning, Organism/legislation & jurisprudence ; Embryo Research ; Embryo, Mammalian/*cytology ; Humans ; *Nuclear Transfer Techniques ; *Stem Cells ; *Terminology as Topic ; United States
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  • 3
    Publication Date: 2002-06-22
    Description: Positive-strand RNA viruses such as poliovirus replicate their genomes on intracellular membranes of their eukaryotic hosts. Electron microscopy has revealed that purified poliovirus RNA-dependent RNA polymerase forms planar and tubular oligomeric arrays. The structural integrity of these arrays correlates with cooperative RNA binding and RNA elongation and is sensitive to mutations that disrupt intermolecular contacts predicted by the polymerase structure. Membranous vesicles isolated from poliovirus-infected cells contain structures consistent with the presence of two-dimensional polymerase arrays on their surfaces during infection. Therefore, host cytoplasmic membranes may function as physical foundations for two-dimensional polymerase arrays, conferring the advantages of surface catalysis to viral RNA replication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyle, John M -- Bullitt, Esther -- Bienz, Kurt -- Kirkegaard, Karla -- AI-42119/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2218-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12077417" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Binding Sites ; Catalysis ; Crystallography, X-Ray ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Inclusion Bodies, Viral/metabolism/ultrastructure ; Microscopy, Electron ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Nucleic Acid Conformation ; Poliovirus/*enzymology/physiology ; Protein Conformation ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; RNA Replicase/*chemistry/isolation & purification/*metabolism/ultrastructure ; RNA, Viral/biosynthesis/*metabolism ; Viral Core Proteins/metabolism ; Virus Replication
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  • 4
    Publication Date: 2002-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1320-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12434031" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Planets ; Research Personnel ; Research Support as Topic ; Solar System ; Space Flight/*economics/*organization & administration/trends ; Spacecraft ; United States ; United States National Aeronautics and Space ; Administration/*economics/*organization & administration/trends
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2002 May 24;296(5572):1383.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12029105" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Specimen Banks ; *Research ; Russia ; United States ; *Variola virus ; *World Health Organization
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2002 May 17;296(5571):1212.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016275" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Drug Industry/legislation & jurisprudence ; Drug Screening Assays, Antitumor ; Mice ; *Mice, Transgenic ; National Institutes of Health (U.S.)/legislation & jurisprudence ; *Neoplasms, Experimental ; *Patents as Topic ; United States ; Universities/legislation & jurisprudence
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2002 Nov 22;298(5598):1534.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12446877" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioterrorism ; Financing, Government ; Government Agencies/economics/legislation & jurisprudence/*organization & ; administration ; National Institutes of Health (U.S.) ; Research/*organization & administration ; Research Support as Topic ; Security Measures/economics/legislation & jurisprudence/*organization & ; administration ; United States
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, Robert C -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1728-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459576" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Serodiagnosis/history ; Acquired Immunodeficiency Syndrome/diagnosis/*history/immunology/virology ; CD4-Positive T-Lymphocytes/virology ; Cell Line ; Cells, Cultured ; France ; *HIV/classification/isolation & purification/physiology ; History, 20th Century ; Human T-lymphotropic virus 1/isolation & purification/physiology ; Human T-lymphotropic virus 2/isolation & purification/physiology ; Humans ; Interleukin-2/history/isolation & purification/physiology ; Patents as Topic/history ; RNA-Directed DNA Polymerase/history/isolation & purification/metabolism ; United States ; Virus Cultivation
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):1000-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11834810" target="_blank"〉PubMed〈/a〉
    Keywords: Cardiac Output, Low/surgery/*therapy ; Costs and Cost Analysis ; Device Approval ; Equipment Design ; Heart Failure/surgery/*therapy ; *Heart, Artificial/economics ; *Heart-Assist Devices ; Humans ; Medicare ; United States ; United States Food and Drug Administration
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  • 10
    Publication Date: 2002-02-02
    Description: In bacteria, promoter recognition depends on the RNA polymerase sigma subunit, which combines with the catalytically proficient RNA polymerase core to form the holoenzyme. The major class of bacterial promoters is defined by two conserved elements (the -10 and -35 elements, which are 10 and 35 nucleotides upstream of the initiation point, respectively) that are contacted by sigma in the holoenzyme. We show that recognition of promoters of this class depends on the "flexible flap" domain of the RNA polymerase beta subunit. The flap interacts with conserved region 4 of sigma and triggers a conformational change that moves region 4 into the correct position for interaction with the -35 element. Because the flexible flap is evolutionarily conserved, this domain may facilitate promoter recognition by specificity factors in eukaryotes as well.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuznedelov, Konstantin -- Minakhin, Leonid -- Niedziela-Majka, Anita -- Dove, Simon L -- Rogulja, Dragana -- Nickels, Bryce E -- Hochschild, Ann -- Heyduk, Tomasz -- Severinov, Konstantin -- GM44025/GM/NIGMS NIH HHS/ -- GM50514/GM/NIGMS NIH HHS/ -- R01 GM044025/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 1;295(5556):855-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Waksman Institute, Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11823642" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Amino Acid Sequence ; Bacterial Proteins/chemistry/genetics/*metabolism ; DNA, Bacterial/genetics/metabolism ; DNA-Directed RNA Polymerases/chemistry/genetics/*metabolism ; Energy Transfer ; Escherichia coli/*enzymology/genetics ; Holoenzymes/chemistry/metabolism ; Models, Molecular ; Molecular Sequence Data ; *Promoter Regions, Genetic ; Protein Conformation ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry/metabolism ; Sigma Factor/chemistry/genetics/*metabolism ; *Transcription, Genetic ; Two-Hybrid System Techniques
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Oct 18;298(5593):522-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12386312" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Antineoplastic Agents/*therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Benzamides ; Carcinoma, Non-Small-Cell Lung/*drug therapy/metabolism ; Clinical Trials as Topic ; *Drug Approval ; Drug Industry ; Epidermal Growth Factor/antagonists & inhibitors/metabolism ; Erlotinib Hydrochloride ; Humans ; Imatinib Mesylate ; Lung Neoplasms/*drug therapy/metabolism ; Neoplasms/*drug therapy ; Patient Selection ; Piperazines/therapeutic use ; Pyrimidines/therapeutic use ; Quinazolines/*therapeutic use ; United States ; United States Food and Drug Administration
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):36-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364757" target="_blank"〉PubMed〈/a〉
    Keywords: History, 21st Century ; Politics ; United States ; United States Food and Drug Administration/*organization & administration
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  • 13
    Publication Date: 2002-09-14
    Description: Mutations in the BRCA2 (breast cancer susceptibility gene 2) tumor suppressor lead to chromosomal instability due to defects in the repair of double-strand DNA breaks (DSBs) by homologous recombination, but BRCA2's role in this process has been unclear. Here, we present the 3.1 angstrom crystal structure of a approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif. We also (i) demonstrate that this BRCA2 domain binds single-stranded DNA, (ii) present its 3.5 angstrom structure bound to oligo(dT)9, (iii) provide data that implicate the HTH motif in dsDNA binding, and (iv) show that BRCA2 stimulates RAD51-mediated recombination in vitro. These findings establish that BRCA2 functions directly in homologous recombination and provide a structural and biochemical basis for understanding the loss of recombination-mediated DSB repair in BRCA2-associated cancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Haijuan -- Jeffrey, Philip D -- Miller, Julie -- Kinnucan, Elspeth -- Sun, Yutong -- Thoma, Nicolas H -- Zheng, Ning -- Chen, Phang-Lang -- Lee, Wen-Hwa -- Pavletich, Nikola P -- New York, N.Y. -- Science. 2002 Sep 13;297(5588):1837-48.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Sloan-Kettering Division, Joan and Sanford I. Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12228710" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; BRCA2 Protein/*chemistry/genetics/*metabolism ; Binding Sites ; Crystallography, X-Ray ; DNA/metabolism ; *DNA Repair ; DNA, Single-Stranded/*metabolism ; DNA-Binding Proteins/metabolism ; Genes, BRCA2 ; Helix-Turn-Helix Motifs ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Mice ; Molecular Sequence Data ; Mutation ; Proteasome Endopeptidase Complex ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Proteins/chemistry/*metabolism ; Rad51 Recombinase ; Rats ; *Recombination, Genetic
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gewolb, Josh -- New York, N.Y. -- Science. 2002 Mar 22;295(5563):2205-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11910091" target="_blank"〉PubMed〈/a〉
    Keywords: Bacillus subtilis/genetics/metabolism ; Bacteria/enzymology/genetics ; Bacterial Proteins/biosynthesis ; Cyclosporine/metabolism ; Drug Design ; Fungi/enzymology/genetics ; Genetic Engineering ; Models, Molecular ; Penicillins/biosynthesis ; Peptide Synthases/chemistry/genetics/*metabolism ; *Protein Biosynthesis ; Protein Conformation ; Protein Engineering/*methods ; Protein Subunits ; Proteins/*chemistry ; Stereoisomerism ; Substrate Specificity
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lashof, Joyce C -- Margen, Sheldon -- Swartzberg, John E -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):46-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11962490" target="_blank"〉PubMed〈/a〉
    Keywords: *Dietary Supplements ; *Legislation, Food ; United States ; United States Food and Drug Administration/*legislation & jurisprudence
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ozonoff, David -- Robbins, Anthony -- New York, N.Y. -- Science. 2002 May 24;296(5572):1400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12030273" target="_blank"〉PubMed〈/a〉
    Keywords: New England ; *Public Health/manpower ; United States
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, Laurence R -- New York, N.Y. -- Science. 2002 Apr 19;296(5567):429.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11964444" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *International Cooperation ; *Research ; *Space Flight/economics ; *Spacecraft/economics ; United States
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):28-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11934996" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid beta-Peptides/chemistry ; Animals ; Humans ; Mice ; Protein Conformation ; *Protein Folding ; *Protein Structure, Quaternary ; Proteins/*chemistry ; Rats
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1315-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12434026" target="_blank"〉PubMed〈/a〉
    Keywords: Materials Testing ; Physical Phenomena ; *Physics ; Research Support as Topic ; Space Flight/*organization & administration ; *Spacecraft ; United States ; United States National Aeronautics and Space Administration/*organization & ; administration ; *Weightlessness
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Vivien -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):39-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098684" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; *Biological Science Disciplines ; Brain/anatomy & histology/pathology ; Computational Biology ; Computer Communication Networks ; Copyright ; Database Management Systems ; *Databases, Factual ; *Diagnostic Imaging ; European Union ; Gene Expression Profiling ; Humans ; Imaging, Three-Dimensional ; Internet ; Nervous System Diseases/pathology ; Periodicals as Topic ; Software ; United States
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):1008.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11834814" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Clinical Trials as Topic ; Europe ; Graft Rejection ; Humans ; Islets of Langerhans Transplantation ; Japan ; Liver, Artificial ; Neurons/transplantation ; *Organ Transplantation/adverse effects ; *Swine ; *Transplantation, Heterologous/adverse effects ; United States ; United States Food and Drug Administration ; Virus Diseases/transmission
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Aug 30;297(5586):1463.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12202797" target="_blank"〉PubMed〈/a〉
    Keywords: California ; China ; Gels ; History, 21st Century ; Ophthalmology/history ; Proteins ; Theft/history/*legislation & jurisprudence ; United States ; *Universities/history
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1153-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424345" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Proteins/genetics ; *Bacterial Toxins ; Drug Resistance ; Endotoxins/genetics ; *Food, Genetically Modified/adverse effects ; Hemolysin Proteins ; Humans ; Plants, Genetically Modified/adverse effects ; Starvation ; United States ; Zambia ; Zea mays/*genetics
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 May 24;296(5572):1387-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12029109" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Astronauts ; *Biology ; Budgets ; *Extraterrestrial Environment ; *Research ; *Space Flight ; *Spacecraft ; United States ; United States National Aeronautics and Space Administration ; Weightlessness
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 May 17;296(5571):1216-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016279" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; Budgets ; *Drug Industry ; Europe ; International Cooperation ; Massachusetts ; *Research/economics ; Research Personnel ; Switzerland ; United States ; Universities
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teitelbaum, Steven L -- New York, N.Y. -- Science. 2002 Nov 22;298(5598):1515.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12446873" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Dementia Complex/physiopathology/virology ; *Animal Experimentation ; *Animal Rights ; Animals ; Brain/drug effects/virology ; Cats ; Disease Models, Animal ; Financing, Government ; HIV/drug effects/physiology ; Humans ; Immunodeficiency Virus, Feline/drug effects/physiology ; Methamphetamine/pharmacology ; National Institutes of Health (U.S.) ; *Research Support as Topic ; United States ; Virus Replication/drug effects
    Print ISSN: 0036-8075
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    Publication Date: 2002-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, Erica -- Marshall, Eliot -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):40-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364762" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; *Biological Science Disciplines/education ; *Career Mobility ; Employment ; Fellowships and Scholarships ; Financing, Government ; *National Institutes of Health (U.S.) ; *Research Personnel ; *Research Support as Topic ; United States ; Universities
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGrayne, Sharon Bertsch -- New York, N.Y. -- Science. 2002 May 3;296(5569):851-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉5233 Pullman Avenue, NE, Seattle, WA 98105, USA. McGrayne@alum.swarthmore.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11988556" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/history ; Chemistry, Pharmaceutical/*history ; Drug Design ; History, 20th Century ; *Nobel Prize ; Pharmacology/history ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davidson, Amy L -- New York, N.Y. -- Science. 2002 May 10;296(5570):1038-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. davidson@bcm.tmc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004108" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/*chemistry/metabolism ; Adenosine Triphosphate/metabolism ; Amino Acid Motifs ; Amino Acid Transport Systems, Basic/chemistry/metabolism ; Bacterial Proteins/chemistry/metabolism ; Binding Sites ; Carrier Proteins/chemistry/metabolism ; *DNA-Binding Proteins ; Dimerization ; Escherichia coli/*chemistry/metabolism ; Escherichia coli Proteins/*chemistry/metabolism ; Fungal Proteins/chemistry/metabolism ; Hydrolysis ; Models, Molecular ; *Periplasmic Binding Proteins ; Protein Conformation ; Protein Folding ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Subunits ; *Saccharomyces cerevisiae Proteins ; Vitamin B 12/metabolism
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGrayne, Sharon B -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):47.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11963927" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/history ; Faculty/history ; History, 20th Century ; Marriage ; United States ; Universities/history
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McSweegan, Edward -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):771-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12162320" target="_blank"〉PubMed〈/a〉
    Keywords: Emigration and Immigration/*legislation & jurisprudence ; Government Agencies/*legislation & jurisprudence ; International Cooperation ; National Academy of Sciences (U.S.) ; Research/legislation & jurisprudence ; Research Personnel/*legislation & jurisprudence ; Security Measures/*legislation & jurisprudence ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):28.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11934995" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; China ; *Human Experimentation ; Humans ; Informed Consent ; Internationality ; Research/*standards ; Rural Population ; United States ; United States Dept. of Health and Human Services ; Universities
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seife, Charles -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1257-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12193762" target="_blank"〉PubMed〈/a〉
    Keywords: *Databases, Bibliographic ; Government Agencies ; *Information Storage and Retrieval ; *Internet ; *Natural Science Disciplines ; Online Systems ; *Publishing ; United States
    Print ISSN: 0036-8075
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  • 34
    Publication Date: 2002-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gostin, Lawrence O -- Sapsin, Jason W -- Teret, Stephen P -- Burris, Scott -- Mair, Julie Samia -- Hodge, James G Jr -- Vernick, Jon S -- New York, N.Y. -- Science. 2002 Dec 13;298(5601):2129; author reply 2129.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12481781" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioterrorism ; *Civil Rights ; Health Policy ; Humans ; Public Health/*legislation & jurisprudence ; *State Government ; United States
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    Publication Date: 2002-03-09
    Description: The structure of the membrane protein formate dehydrogenase-N (Fdn-N), a major component of Escherichia coli nitrate respiration, has been determined at 1.6 angstroms. The structure demonstrates 11 redox centers, including molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters, two heme b groups, and a menaquinone analog. These redox centers are aligned in a single chain, which extends almost 90 angstroms through the enzyme. The menaquinone reduction site associated with a possible proton pathway was also characterized. This structure provides critical insights into the proton motive force generation by redox loop, a common mechanism among a wide range of respiratory enzymes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jormakka, Mika -- Tornroth, Susanna -- Byrne, Bernadette -- Iwata, So -- New York, N.Y. -- Science. 2002 Mar 8;295(5561):1863-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biomedical Sciences, Imperial College, London SW7 2AZ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11884747" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Catalysis ; Catalytic Domain ; Cell Membrane/enzymology ; Crystallography, X-Ray ; Electron Transport ; Escherichia coli/*enzymology ; Formate Dehydrogenases/*chemistry/metabolism ; Formates/metabolism ; Guanine Nucleotides/chemistry/metabolism ; Hydrogen Bonding ; Iron-Sulfur Proteins/chemistry/metabolism ; Membrane Potentials ; Models, Molecular ; Nitrate Reductases/chemistry/metabolism ; Oxidation-Reduction ; Protein Conformation ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Subunits ; *Proton-Motive Force ; Protons ; Pterins/chemistry/metabolism ; Vitamin K 2/chemistry/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1694-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459558" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Computational Biology ; *Genetic Research ; *Genomics ; *Human Genome Project ; Humans ; *National Institutes of Health (U.S.) ; Sequence Analysis, DNA ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tickell, Crispin -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):737.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12161617" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution/economics/prevention & control ; Atmosphere/chemistry ; Carbon/metabolism ; *Ecosystem ; Europe ; *Greenhouse Effect ; Humans ; Industry/economics/legislation & jurisprudence ; International Cooperation ; Japan ; Public Policy ; *Public Relations ; South Africa ; United States ; Vehicle Emissions/prevention & control
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Mar 1;295(5560):1623.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11872810" target="_blank"〉PubMed〈/a〉
    Keywords: Body Constitution ; Budgets ; Equipment Design ; Female ; Humans ; Male ; *Sex Characteristics ; *Space Flight ; *Space Suits ; United States ; *United States National Aeronautics and Space Administration/economics ; Weightlessness
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2002 Jul 19;297(5580):321.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12130761" target="_blank"〉PubMed〈/a〉
    Keywords: Accreditation ; Advisory Committees ; Ethics, Professional/*education ; Financial Support ; Financing, Government ; Institute of Medicine (U.S.) ; Research/*standards ; *Scientific Misconduct ; United States ; United States Office of Research Integrity ; *Universities
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):1945-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12065806" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/*adverse effects ; Carbon/*adverse effects ; Cities ; Computer Simulation ; Heart Diseases/*mortality ; Humans ; Lung Diseases/*mortality ; *Models, Statistical ; Particle Size ; Risk Assessment ; *Software ; United States ; United States Environmental Protection Agency
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meisterernst, Michael -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):984-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gene Expression Department, National Research Center for Environment and Health-GSF Institute of Molecular Immunology, Marchionini-Strasse 25, D-81377 Munich, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11834806" target="_blank"〉PubMed〈/a〉
    Keywords: CCAAT-Enhancer-Binding Proteins/chemistry/metabolism ; Chromatin/metabolism ; DNA-Binding Proteins/chemistry/metabolism ; Herpes Simplex Virus Protein Vmw65/chemistry/metabolism ; Macromolecular Substances ; Microscopy, Electron ; Molecular Weight ; Protein Conformation ; Protein Structure, Tertiary ; Protein Subunits ; RNA Polymerase II/chemistry/metabolism ; Sterol Regulatory Element Binding Protein 1 ; Trans-Activators/*chemistry/isolation & purification/*metabolism ; *Transcription Factors ; *Transcription, Genetic
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2002 Nov 22;298(5598):1568.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12446898" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; *Biological Science Disciplines/history ; History, 21st Century ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hagmann, Michael -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2006-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896256" target="_blank"〉PubMed〈/a〉
    Keywords: Acetic Acid/chemistry ; Amino Acids/chemistry ; Catalysis ; Chemistry, Physical/history ; *Evolution, Chemical ; History, 20th Century ; History, 21st Century ; Iron/chemistry ; Organic Chemicals/chemistry ; *Origin of Life ; Sulfides/chemistry ; Temperature ; Thermodynamics ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-07-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2002 Jul 26;297(5581):506-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12142512" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics/organization & administration ; Administrative Personnel ; Financing, Government ; *Government Agencies ; Humans ; Industry ; Minority Groups ; Research Personnel ; *Research Support as Topic ; *Science/education ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1160.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424350" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethical Issues ; Biological Specimen Banks/*ethics ; Confidentiality ; Dna ; Databases, Factual/ethics ; Databases, Genetic/ethics ; Ethics, Clinical ; Humans ; Medical Records Systems, Computerized/ethics ; Private Sector/*ethics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):39.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364761" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cnidaria ; *Conservation of Natural Resources ; *Ecosystem ; Financing, Government ; *Marine Biology ; Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1158-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424349" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Bioethical Issues ; Biological Specimen Banks/ethics ; Confidentiality ; *Databases, Factual/ethics ; *Databases, Genetic/ethics ; Diet ; Ethics, Clinical ; Genetic Markers ; Genetic Predisposition to Disease ; *Genetics, Medical/ethics ; *Genetics, Population/ethics ; Humans ; Iceland ; Informed Consent ; Life Style ; *Medical Records Systems, Computerized/ethics ; Registries ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Jan 4;295(5552):32-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11778022" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Astronomy/economics ; Budgets ; *Exobiology ; Meteoroids ; Minor Planets ; National Academy of Sciences (U.S.) ; Planets ; Politics ; *Solar System ; United States ; United States National Aeronautics and Space Administration/economics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-16
    Description: We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber. This methodology can be applied to the spatial organization of entire genomes in organisms from bacteria to human. Using the yeast Saccharomyces cerevisiae, we could confirm known qualitative features of chromosome organization within the nucleus and dynamic changes in that organization during meiosis. We also analyzed yeast chromosome III at the G1 stage of the cell cycle. We found that chromatin is highly flexible throughout. Furthermore, functionally distinct AT- and GC-rich domains were found to exhibit different conformations, and a population-average 3D model of chromosome III could be determined. Chromosome III emerges as a contorted ring.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dekker, Job -- Rippe, Karsten -- Dekker, Martijn -- Kleckner, Nancy -- GM25326/GM/NIGMS NIH HHS/ -- GM44794/GM/NIGMS NIH HHS/ -- R01 GM025326/GM/NIGMS NIH HHS/ -- R01 GM044794/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 15;295(5558):1306-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. jdekker@fas.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11847345" target="_blank"〉PubMed〈/a〉
    Keywords: AT Rich Sequence ; Cell Fractionation ; Cell Nucleus/ultrastructure ; Centromere/chemistry/ultrastructure ; Chromatin/*chemistry/metabolism ; Chromosomes, Fungal/*chemistry/genetics/metabolism/*ultrastructure ; Cross-Linking Reagents ; Deoxyribonuclease EcoRI/metabolism ; Formaldehyde ; *G1 Phase ; GC Rich Sequence ; Genome, Fungal ; Mathematics ; *Meiosis ; Mitosis ; Polymerase Chain Reaction ; Protein Conformation ; Saccharomyces cerevisiae/*genetics/physiology/ultrastructure ; Telomere/chemistry/ultrastructure
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- Stokstad, Erik -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):1973-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242412" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; Advisory Committees ; *Agriculture ; *Bioterrorism ; Government ; Government Agencies ; *National Academy of Sciences (U.S.) ; United States ; United States Department of Agriculture
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  • 51
    Publication Date: 2002-01-19
    Description: Mycobacterium tuberculosis (Mtb) mounts a stubborn defense against oxidative and nitrosative components of the immune response. Dihydrolipoamide dehydrogenase (Lpd) and dihydrolipoamide succinyltransferase (SucB) are components of alpha-ketoacid dehydrogenase complexes that are central to intermediary metabolism. We find that Lpd and SucB support Mtb's antioxidant defense. The peroxiredoxin alkyl hydroperoxide reductase (AhpC) is linked to Lpd and SucB by an adaptor protein, AhpD. The 2.0 angstrom AhpD crystal structure reveals a thioredoxin-like active site that is responsive to lipoamide. We propose that Lpd, SucB (the only lipoyl protein detected in Mtb), AhpD, and AhpC together constitute a nicotinamide adenine dinucleotide (reduced)-dependent peroxidase and peroxynitrite reductase. AhpD thus represents a class of thioredoxin-like molecules that enables an antioxidant defense.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bryk, R -- Lima, C D -- Erdjument-Bromage, H -- Tempst, P -- Nathan, C -- HL61241/HL/NHLBI NIH HHS/ -- P30 CA08748/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):1073-7. Epub 2002 Jan 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799204" target="_blank"〉PubMed〈/a〉
    Keywords: Acyltransferases/*metabolism ; Amino Acid Sequence ; Antioxidants ; Binding Sites ; Catalysis ; Cloning, Molecular ; Crystallization ; Crystallography, X-Ray ; Dihydrolipoamide Dehydrogenase/*metabolism ; Hydrogen Bonding ; Hydrogen Peroxide/metabolism ; Models, Molecular ; Molecular Sequence Data ; Mycobacterium tuberculosis/*enzymology/genetics/metabolism ; NAD/metabolism ; Oxidation-Reduction ; Oxidoreductases/*metabolism ; Peroxidases/*chemistry/*metabolism ; Peroxiredoxins ; Peroxynitrous Acid/metabolism ; Protein Conformation ; Protein Folding ; Protein Structure, Quaternary ; Thioctic Acid/*analogs & derivatives/metabolism ; Thioredoxins/chemistry/metabolism
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  • 52
    Publication Date: 2002-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2002 Sep 6;297(5587):1630-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12215622" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/economics ; Bioterrorism/economics/*prevention & control ; Cooperative Behavior ; Financing, Government ; Government Agencies/economics ; National Institutes of Health (U.S.)/economics ; *Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, Dana -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1866-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471229" target="_blank"〉PubMed〈/a〉
    Keywords: Climate ; Dry Ice ; Extraterrestrial Environment ; *Ice ; *Mars ; Space Flight ; United States ; United States National Aeronautics and Space Administration ; Water
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-24
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220017/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220017/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henry, Michelle R -- Cho, Mildred K -- Weaver, Meredith A -- Merz, Jon F -- R01 HG002034/HG/NHGRI NIH HHS/ -- R01 HG002034-01A1/HG/NHGRI NIH HHS/ -- R01 HG002034-01A1S1/HG/NHGRI NIH HHS/ -- R01 HG002034-01A1S2/HG/NHGRI NIH HHS/ -- R01 HG002034-02/HG/NHGRI NIH HHS/ -- R01 HG002034-03/HG/NHGRI NIH HHS/ -- R01HG02034/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1279.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Bioethics, University of Pennsylvania, Philadelphia, PA, 19104-3308, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12193770" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/legislation & jurisprudence ; Commerce/*legislation & jurisprudence ; *Dna ; Financing, Government ; *Genetics ; Interviews as Topic ; National Institutes of Health (U.S.) ; *Patents as Topic ; Research Support as Topic ; *Technology Transfer ; United States ; Universities/*legislation & jurisprudence
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):754-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12161624" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Biotechnology/*economics/legislation & jurisprudence ; Cloning, Organism/economics/legislation & jurisprudence ; *DNA/genetics ; Embryo, Mammalian/cytology ; Europe ; Genes ; Humans ; Patents as Topic/*legislation & jurisprudence ; *Stem Cells/metabolism ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-23
    Description: Internal protein dynamics are intimately connected to enzymatic catalysis. However, enzyme motions linked to substrate turnover remain largely unknown. We have studied dynamics of an enzyme during catalysis at atomic resolution using nuclear magnetic resonance relaxation methods. During catalytic action of the enzyme cyclophilin A, we detect conformational fluctuations of the active site that occur on a time scale of hundreds of microseconds. The rates of conformational dynamics of the enzyme strongly correlate with the microscopic rates of substrate turnover. The present results, together with available structural data, allow a prediction of the reaction trajectory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eisenmesser, Elan Zohar -- Bosco, Daryl A -- Akke, Mikael -- Kern, Dorothee -- GM62117/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 22;295(5559):1520-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11859194" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Catalysis ; Cyclophilin A/*chemistry/*metabolism ; Hydrogen Bonding ; Isomerism ; Kinetics ; Mathematics ; Models, Molecular ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loomis, Dana -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1335-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12436979" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Federal Government ; Human Engineering ; *National Institute for Occupational Safety and Health (U.S.) ; Peer Review, Research ; *Politics ; Public Policy ; Research Support as Topic ; United States ; *United States Dept. of Health and Human Services
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2002 Mar 1;295(5560):1601.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11872803" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Vaccines ; *Biological Warfare ; *Botulinum Toxins, Type A/administration & dosage/therapeutic use ; Clostridium botulinum/immunology ; *Cosmetic Techniques ; *Drug Approval ; Humans ; *Public Health ; United States ; United States Food and Drug Administration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Sep 13;297(5588):1788-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12228693" target="_blank"〉PubMed〈/a〉
    Keywords: *Diet ; Dietary Carbohydrates/administration & dosage ; Dietary Fats/administration & dosage ; Dietary Fiber/administration & dosage ; Dietary Proteins/administration & dosage ; Exercise ; *Health ; Humans ; *Institute of Medicine (U.S.) ; *Nutrition Policy ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2002 Oct 18;298(5593):526.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12386313" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; *Biology/history ; Caenorhabditis elegans/*physiology ; Great Britain ; History, 21st Century ; *Nobel Prize ; United States
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  • 61
    Publication Date: 2002-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1264-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12193766" target="_blank"〉PubMed〈/a〉
    Keywords: *Anthrax ; Bacillus anthracis ; Biological Warfare ; *Bioterrorism ; *Government Agencies ; History, 21st Century ; Humans ; *Social Control, Formal ; Spores, Bacterial ; United States
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  • 62
    Publication Date: 2002-08-24
    Description: Populations of the garter snake Thamnophis sirtalis have evolved geographically variable resistance to tetrodotoxin (TTX) in a coevolutionary arms race with their toxic prey, newts of the genus Taricha. Here, we identify a physiological mechanism, the expression of TTX-resistant sodium channels in skeletal muscle, responsible for adaptive diversification in whole-animal resistance. Both individual and population differences in the ability of skeletal muscle fibers to function in the presence of TTX correlate closely with whole-animal measures of TTX resistance. Demonstration of individual variation in an essential physiological function responsible for the adaptive differences among populations is a step toward linking the selective consequences of coevolutionary interactions to geographic and phylogenetic patterns of diversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geffeney, Shana -- Brodie, Edmund D Jr -- Ruben, Peter C -- Brodie, Edmund D 3rd -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1336-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Utah State University, Logan, UT 84322, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12193784" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Adaptation, Physiological ; Animals ; *Biological Evolution ; Colubridae/*physiology ; Drug Resistance ; Linear Models ; Locomotion/drug effects ; Muscle Fibers, Skeletal/drug effects/physiology ; Muscle, Skeletal/drug effects/*physiology ; Neuromuscular Junction/drug effects/physiology ; Predatory Behavior ; *Salamandridae/metabolism ; Skin/chemistry ; Sodium Channels/*drug effects/physiology ; Tetrodotoxin/*toxicity ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):749-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12161619" target="_blank"〉PubMed〈/a〉
    Keywords: Bioterrorism/*prevention & control ; DNA, Viral/chemical synthesis/genetics ; Genetic Engineering ; Humans ; National Academy of Sciences (U.S.) ; Poliovirus/genetics/physiology ; Publishing/*legislation & jurisprudence/standards ; Research/*legislation & jurisprudence ; Security Measures/*legislation & jurisprudence/standards ; United States ; Variola virus/genetics/physiology ; Virus Replication
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 May 24;296(5572):1391-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12029111" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Mapping/economics ; Continental Population Groups/genetics ; Costs and Cost Analysis ; Databases, Nucleic Acid ; Financing, Government ; Genetic Predisposition to Disease ; *Genome, Human ; *Genomics ; Genotype ; *Haplotypes ; Humans ; Mutation ; National Institutes of Health (U.S.) ; Polymorphism, Single Nucleotide ; Research Support as Topic ; United States
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  • 65
    Publication Date: 2002-04-16
    Description: One of the most complex biosynthetic processes in metallobiochemistry is the assembly of nitrogenase, the key enzyme in biological nitrogen fixation. We describe here the crystal structure of an iron-molybdenum cofactor-deficient form of the nitrogenase MoFe protein, into which the cofactor is inserted in the final step of MoFe protein assembly. The MoFe protein folds as a heterotetramer containing two copies each of the homologous alpha and beta subunits. In this structure, one of the three alpha subunit domains exhibits a substantially changed conformation, whereas the rest of the protein remains essentially unchanged. A predominantly positively charged funnel is revealed; this funnel is of sufficient size to accommodate insertion of the negatively charged cofactor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmid, Benedikt -- Ribbe, Markus W -- Einsle, Oliver -- Yoshida, Mika -- Thomas, Leonard M -- Dean, Dennis R -- Rees, Douglas C -- Burgess, Barbara K -- New York, N.Y. -- Science. 2002 Apr 12;296(5566):352-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Chemistry and Chemical Engineering, Mail Code 147-75CH, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11951047" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Azotobacter vinelandii/*enzymology ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; Dimerization ; Hydrogen Bonding ; Models, Molecular ; Molecular Sequence Data ; Molybdoferredoxin/*chemistry/genetics/*metabolism ; Protein Conformation ; Protein Folding ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Static Electricity ; Surface Properties
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  • 66
    Publication Date: 2002-09-21
    Description: To make messenger RNA transcripts, bacteriophage T7 RNA polymerase (T7 RNAP) undergoes a transition from an initiation phase, which only makes short RNA fragments, to a stable elongation phase. We have determined at 2.1 angstrom resolution the crystal structure of a T7 RNAP elongation complex with 30 base pairs of duplex DNA containing a "transcription bubble" interacting with a 17-nucleotide RNA transcript. The transition from an initiation to an elongation complex is accompanied by a major refolding of the amino-terminal 300 residues. This results in loss of the promoter binding site, facilitating promoter clearance, and creates a tunnel that surrounds the RNA transcript after it peels off a seven-base pair heteroduplex. Formation of the exit tunnel explains the enhanced processivity of the elongation complex. Downstream duplex DNA binds to the fingers domain, and its orientation relative to upstream DNA in the initiation complex implies an unwinding that could facilitate formation of the open promoter complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yin, Y Whitney -- Steitz, Thomas A -- GM57510/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1387-95. Epub 2002 Sep 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520-8114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242451" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteriophage T7/enzymology ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; DNA/*chemistry/metabolism ; DNA-Directed RNA Polymerases/*chemistry/genetics/*metabolism ; Models, Molecular ; Mutation ; N-Acetylmuramoyl-L-alanine Amidase/metabolism ; Nucleic Acid Heteroduplexes ; Promoter Regions, Genetic ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Subunits ; RNA Polymerase II/chemistry ; RNA, Messenger/*chemistry/metabolism ; Taq Polymerase/chemistry ; Templates, Genetic ; Transcription Initiation Site ; *Transcription, Genetic ; Viral Proteins
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gewolb, Josh -- New York, N.Y. -- Science. 2002 Jan 4;295(5552):31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11778021" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Biochemistry/history ; History, 21st Century ; United States ; Universities
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  • 68
    Publication Date: 2002-02-23
    Description: The chromodomain of the HP1 family of proteins recognizes histone tails with specifically methylated lysines. Here, we present structural, energetic, and mutational analyses of the complex between the Drosophila HP1 chromodomain and the histone H3 tail with a methyllysine at residue 9, a modification associated with epigenetic silencing. The histone tail inserts as a beta strand, completing the beta-sandwich architecture of the chromodomain. The methylammonium group is caged by three aromatic side chains, whereas adjacent residues form discerning contacts with one face of the chromodomain. Comparison of dimethyl- and trimethyllysine-containing complexes suggests a role for cation-pi and van der Waals interactions, with trimethylation slightly improving the binding affinity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobs, Steven A -- Khorasanizadeh, Sepideh -- GM63959-01/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2080-3. Epub 2002 Feb 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908-0733, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11859155" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Chromosomal Proteins, Non-Histone/*chemistry/genetics/*metabolism ; Crystallography, X-Ray ; Drosophila Proteins/chemistry/metabolism ; Histones/*chemistry/genetics/*metabolism ; Hydrogen Bonding ; Lysine/*analogs & derivatives/chemistry/*metabolism ; Methylation ; Models, Molecular ; Molecular Sequence Data ; Mutagenesis ; Peptides/chemistry/metabolism ; Point Mutation ; Protein Binding ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Sequence Alignment
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blanchard, Michelle -- New York, N.Y. -- Science. 2002 Aug 16;297(5584):1122.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12192658" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/organization & administration ; *Communicable Diseases ; *Military Medicine ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- Enserink, Martin -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):942.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411676" target="_blank"〉PubMed〈/a〉
    Keywords: *Clinical Trials as Topic ; *Drug Combinations ; Drug Labeling ; *Estrogen Replacement Therapy/adverse effects ; *Estrogens, Conjugated (USP)/adverse effects/therapeutic use ; Female ; Great Britain ; Hot Flashes/drug therapy ; Humans ; *Medroxyprogesterone Acetate/adverse effects/therapeutic use ; Menopause ; Middle Aged ; National Institutes of Health (U.S.) ; Risk Factors ; United States
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  • 71
    Publication Date: 2002-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parascandola, Mark -- New York, N.Y. -- Science. 2002 Oct 11;298(5592):338.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12376672" target="_blank"〉PubMed〈/a〉
    Keywords: Brain Neoplasms/epidemiology/*etiology ; Expert Testimony ; Humans ; *Jurisprudence ; Male ; Maryland ; Peer Review, Research ; Publishing ; Risk Factors ; *Telephone ; United States
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  • 72
    Publication Date: 2002-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):1972-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242410" target="_blank"〉PubMed〈/a〉
    Keywords: France ; *International Cooperation ; Italy ; *Mars ; *Space Flight ; United States ; United States National Aeronautics and Space Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):748-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12161618" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/abnormalities/*drug effects/metabolism/*physiopathology ; Genetics, Medical/economics/trends ; Government ; Humans ; Magnetic Resonance Imaging/economics/trends ; Neurosciences/*economics/*trends ; Research/economics/trends ; Substance-Related Disorders/diagnosis/genetics/*physiopathology ; United States
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  • 74
    Publication Date: 2002-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zerhouni, Elias -- New York, N.Y. -- Science. 2002 Sep 27;297(5590):2197-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12351769" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Specimen Banks ; Bioterrorism ; Budgets ; Clinical Trials as Topic ; Financing, Government ; National Institutes of Health (U.S.)/economics/*organization & administration ; *Research ; Research Support as Topic ; Stem Cells ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teeri, James A -- Raven, Peter H -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1893.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12474846" target="_blank"〉PubMed〈/a〉
    Keywords: Data Collection ; *Ecology ; Ecosystem ; Financing, Government ; *Government Agencies/economics/organization & administration ; Human Activities ; United States
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  • 76
    Publication Date: 2002-06-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Jun 28;296(5577):2310-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12089411" target="_blank"〉PubMed〈/a〉
    Keywords: *Academic Medical Centers ; *Graft Rejection/genetics ; Humans ; *Intellectual Property ; Massachusetts ; Ownership ; Patents as Topic ; Research ; *Theft ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-06-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2002 Jun 28;296(5577):2316.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12089417" target="_blank"〉PubMed〈/a〉
    Keywords: Australia ; Financing, Government ; Foreign Professional Personnel/*legislation & jurisprudence ; *International Cooperation ; National Institutes of Health (U.S.)/*legislation & jurisprudence ; *Patents as Topic ; Public Policy ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
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  • 78
    Publication Date: 2002-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1328-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12434035" target="_blank"〉PubMed〈/a〉
    Keywords: *Education, Graduate ; Humans ; *Labor Unions ; United States ; *Universities
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-01-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Jan 18;295(5554):435.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799222" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/economics/*organization & administration ; Aerospace Medicine/economics/*organization & administration ; *Astronauts ; Budgets ; History, 21st Century ; Humans ; Research ; Research Support as Topic ; *Space Flight ; United States ; United States National Aeronautics and Space Administration/economics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2002 Feb 1;295(5556):785.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11823618" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioterrorism ; *Budgets ; National Institutes of Health (U.S.)/*economics/organization & administration ; *Neoplasms ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2002 May 10;296(5570):1001-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004095" target="_blank"〉PubMed〈/a〉
    Keywords: National Academy of Sciences (U.S.)/*organization & administration ; United States
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  • 82
    Publication Date: 2002-04-27
    Description: Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levinson, Douglas F -- Holmans, Peter A -- Laurent, Claudine -- Riley, Brien -- Pulver, Ann E -- Gejman, Pablo V -- Schwab, Sibylle G -- Williams, Nigel M -- Owen, Michael J -- Wildenauer, Dieter B -- Sanders, Alan R -- Nestadt, Gerald -- Mowry, Bryan J -- Wormley, Brandon -- Bauche, Stephanie -- Soubigou, Stephane -- Ribble, Robert -- Nertney, Deborah A -- Liang, Kung Yee -- Martinolich, Laura -- Maier, Wolfgang -- Norton, Nadine -- Williams, Hywel -- Albus, Margot -- Carpenter, Eric B -- DeMarchi, Nicola -- Ewen-White, Kelly R -- Walsh, Dermot -- Jay, Maurice -- Deleuze, Jean-Francois -- O'Neill, F Anthony -- Papadimitriou, George -- Weilbaecher, Ann -- Lerer, Bernard -- O'Donovan, Michael C -- Dikeos, Dimitris -- Silverman, Jeremy M -- Kendler, Kenneth S -- Mallet, Jacques -- Crowe, Raymond R -- Walters, Marilyn -- G9309834/Medical Research Council/United Kingdom -- G9810900/Medical Research Council/United Kingdom -- K24-MH64197/MH/NIMH NIH HHS/ -- KO2-01207/PHS HHS/ -- MH 41953/MH/NIMH NIH HHS/ -- MH 45390/MH/NIMH NIH HHS/ -- MH 52537/MH/NIMH NIH HHS/ -- MH61602/MH/NIMH NIH HHS/ -- R01-MH57314/MH/NIMH NIH HHS/ -- U01 MH46289/MH/NIMH NIH HHS/ -- U01 MH46318/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):739-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. dfl@mail.med.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976456" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Alleles ; Australia ; Canada ; Chromosomes, Human, Pair 1/*genetics ; Europe ; Female ; Genes, Recessive ; *Genetic Linkage ; *Genetic Predisposition to Disease ; Genotype ; Humans ; Lod Score ; Male ; Microsatellite Repeats ; Pedigree ; Schizophrenia/ethnology/*genetics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamburg, Margaret A -- New York, N.Y. -- Science. 2002 Feb 22;295(5559):1425.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11859157" target="_blank"〉PubMed〈/a〉
    Keywords: Bioterrorism ; Communicable Disease Control ; *Communicable Diseases/diagnosis/therapy ; Disease Notification ; *Disease Outbreaks ; Humans ; Population Surveillance ; *Public Health/manpower ; Public Health Administration ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donnelly, John J -- Barnett, Susan W -- Dorenbaum, Alejandro -- Stamatatos, Leonidas -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1277-8; author reply 1277-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12194177" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*immunology ; Animals ; Drug Evaluation, Preclinical ; HIV Antibodies/biosynthesis/immunology ; HIV-1/*immunology ; Humans ; Macaca mulatta ; National Institutes of Health (U.S.) ; Neutralization Tests ; United States ; Vaccines, DNA/*immunology ; Viral Envelope Proteins/*immunology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):1957-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12065816" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/economics/history/*organization & administration ; Biotechnology ; Budgets ; Computational Biology ; *Genomics/history ; History, 20th Century ; History, 21st Century ; Maryland ; Molecular Biology/history ; National Institutes of Health (U.S.) ; Research ; Research Personnel ; Research Support as Topic ; Sequence Analysis, DNA ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-07-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2002 Jul 26;297(5581):492.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12142501" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Neoplasms/epidemiology/etiology ; Confidence Intervals ; *Controlled Clinical Trials as Topic/standards ; Coronary Disease/epidemiology/etiology ; Estrogen Replacement Therapy/*adverse effects ; Female ; Great Britain ; Humans ; Menopause ; Risk Assessment ; Stroke/epidemiology/etiology ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helvarg, David -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):46.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11963926" target="_blank"〉PubMed〈/a〉
    Keywords: *Science ; *Societies, Scientific ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raven, Peter H -- New York, N.Y. -- Science. 2002 Aug 9;297(5583):954-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Missouri Botanical Garden, St. Louis, MO 63166, USA. praven@nas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12169719" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Conservation of Natural Resources ; *Ecosystem ; *Environment ; Global Health ; Humans ; *International Cooperation ; *Science ; Technology ; Technology Transfer ; United States
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  • 89
    Publication Date: 2002-09-07
    Description: A high-resolution crystallographic analysis of the nitrogenase MoFe-protein reveals a previously unrecognized ligand coordinated to six iron atoms in the center of the catalytically essential FeMo-cofactor. The electron density for this ligand is masked in structures with resolutions lower than 1.55 angstroms, owing to Fourier series termination ripples from the surrounding iron and sulfur atoms in the cofactor. The central atom completes an approximate tetrahedral coordination for the six iron atoms, instead of the trigonal coordination proposed on the basis of lower resolution structures. The crystallographic refinement at 1.16 angstrom resolution is consistent with this newly detected component being a light element, most plausibly nitrogen. The presence of a nitrogen atom in the cofactor would have important implications for the mechanism of dinitrogen reduction by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Einsle, Oliver -- Tezcan, F Akif -- Andrade, Susana L A -- Schmid, Benedikt -- Yoshida, Mika -- Howard, James B -- Rees, Douglas C -- New York, N.Y. -- Science. 2002 Sep 6;297(5587):1696-700.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Division of Chemistry and Chemical Engineering, California Institute of Technology, Mail Code 147-75CH, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12215645" target="_blank"〉PubMed〈/a〉
    Keywords: Azotobacter vinelandii/enzymology ; Coenzymes/*chemistry/metabolism ; Crystallography, X-Ray ; Ligands ; Models, Molecular ; Molybdoferredoxin/*chemistry/metabolism ; Nitrogen/chemistry ; Nitrogenase/*chemistry/metabolism ; Protein Conformation
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  • 90
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caplan, Arthur L -- Sankar, Pamela -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):923.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411671" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Warfare ; *Chemical Warfare ; Clinical Trials, Phase I as Topic ; Ethics, Research ; Guidelines as Topic ; Human Experimentation/*ethics ; Humans ; Informed Consent ; Nontherapeutic Human Experimentation/*ethics ; *Research Subjects ; Security Measures ; United States
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  • 91
    Publication Date: 2002-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- Lawler, Andrew -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):1944-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12065805" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioterrorism ; Budgets ; *Government Agencies/economics/organization & administration ; *Research ; Research Personnel ; *Security Measures ; *Terrorism ; United States ; United States Department of Agriculture/economics ; United States Dept. of Health and Human Services/economics
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  • 92
    Publication Date: 2002-05-11
    Description: The ABC transporters are ubiquitous membrane proteins that couple adenosine triphosphate (ATP) hydrolysis to the translocation of diverse substrates across cell membranes. Clinically relevant examples are associated with cystic fibrosis and with multidrug resistance of pathogenic bacteria and cancer cells. Here, we report the crystal structure at 3.2 angstrom resolution of the Escherichia coli BtuCD protein, an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and appears to represent a conserved motif among the ABC transporters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Locher, Kaspar P -- Lee, Allen T -- Rees, Douglas C -- New York, N.Y. -- Science. 2002 May 10;296(5570):1091-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, Mail Code 147-75CH, California Institute of Technology, Pasadena, CA 91125, USA. locher@caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004122" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/*chemistry/metabolism ; Adenosine Triphosphate/metabolism ; Amino Acid Motifs ; Amino Acid Sequence ; Binding Sites ; Biological Transport ; Cell Membrane/chemistry ; Crystallization ; Crystallography, X-Ray ; Dimerization ; Escherichia coli/*chemistry ; Escherichia coli Proteins/*chemistry/metabolism ; Hydrolysis ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protein Folding ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Subunits ; Vitamin B 12/*metabolism
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2305-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493883" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Graduate ; *Emigration and Immigration ; *National Academy of Sciences (U.S.) ; *Research Personnel ; *Security Measures ; Students ; *Travel ; United States
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  • 94
    Publication Date: 2002-05-23
    Description: The crystal structure of the initiating form of Thermus aquaticus RNA polymerase, containing core RNA polymerase (alpha2betabeta'omega) and the promoter specificity sigma subunit, has been determined at 4 angstrom resolution. Important structural features of the RNA polymerase and their roles in positioning sigma within the initiation complex are delineated, as well as the role played by sigma in modulating the opening of the RNA polymerase active-site channel. The two carboxyl-terminal domains of sigma are separated by 45 angstroms on the surface of the RNA polymerase, but are linked by an extended loop. The loop winds near the RNA polymerase active site, where it may play a role in initiating nucleotide substrate binding, and out through the RNA exit channel. The advancing RNA transcript must displace the loop, leading to abortive initiation and ultimately to sigma release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murakami, Katsuhiko S -- Masuda, Shoko -- Darst, Seth A -- GM53759/GM/NIGMS NIH HHS/ -- GM61898/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 May 17;296(5571):1280-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016306" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; DNA, Bacterial/metabolism ; DNA-Directed RNA Polymerases/*chemistry/*metabolism ; Eukaryotic Cells/metabolism ; Holoenzymes/chemistry/metabolism ; Models, Molecular ; Promoter Regions, Genetic ; Protein Conformation ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; RNA, Bacterial/metabolism ; RNA, Messenger/metabolism ; Sigma Factor/metabolism ; Thermus/*enzymology ; *Transcription, Genetic
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  • 95
    Publication Date: 2002-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Renner, Rebecca -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):938-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411672" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aromatase/metabolism ; Atrazine/administration & dosage/*toxicity ; Disorders of Sex Development/*chemically induced ; Herbicides/administration & dosage/*toxicity ; Male ; Metamorphosis, Biological ; Oocytes ; Population Density ; Rana pipiens/*abnormalities/growth & development/metabolism ; Testis/*abnormalities ; United States ; United States Environmental Protection Agency ; Water Pollutants, Chemical/toxicity ; Xenopus laevis/*abnormalities/growth & development/metabolism
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moses, William W -- New York, N.Y. -- Science. 2002 Jan 11;295(5553):275.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11789535" target="_blank"〉PubMed〈/a〉
    Keywords: California ; Humans ; *Isotope Labeling ; *Laboratories ; *National Institutes of Health (U.S.) ; Radioactive Waste ; Safety ; *Tritium ; United States
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- Marshall, Eliot -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):639-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976419" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthrax/*prevention & control ; *Anthrax Vaccines/administration & dosage/adverse effects/immunology ; *Antigens, Bacterial ; Bacterial Toxins/*immunology ; Humans ; Macaca mulatta ; Military Medicine ; National Institutes of Health (U.S.) ; Respiratory Tract Infections/prevention & control ; United States ; Vaccines, Synthetic/administration & dosage/adverse effects/immunology
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  • 98
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baird, Patricia -- Downie, Jocelyn -- Thompson, Jon -- New York, N.Y. -- Science. 2002 Sep 27;297(5590):2211.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Genetics, University of British Columbia, Vancouver, BC, V6T 1Z3 Canada. pbaird@interchange.ubc.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12351773" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; Clinical Trials as Topic/legislation & jurisprudence/*standards ; *Confidentiality ; Conflict of Interest ; *Disclosure ; *Drug Industry/legislation & jurisprudence ; Ethics, Clinical ; Hospitals, Teaching ; Humans ; Multicenter Studies as Topic ; *Patient Rights ; Periodicals as Topic ; Publishing ; Research Support as Topic ; Risk ; United States ; Universities
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1313.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12434024" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Cloning, Organism/legislation & jurisprudence ; Financing, Government ; Government Agencies/economics ; National Institutes of Health (U.S.)/economics ; Politics ; *Research Support as Topic ; *Science ; United States
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  • 100
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):722-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399555" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Government Agencies/*legislation & jurisprudence ; Maps as Topic ; Mexico ; Noise/*adverse effects ; *Oceanography ; Pacific Ocean ; Sound/adverse effects ; United States ; *Whales
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