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  • Springer  (61,770)
  • Annual Reviews
  • Seismological Society of America (SSA)
  • 1995-1999  (62,750)
  • 1980-1984
  • 1965-1969
  • 1945-1949
  • 1997  (62,750)
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  • 1995-1999  (62,750)
  • 1980-1984
  • 1965-1969
  • 1945-1949
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  • 101
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 42 (1997), S. 231-267 
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Silks belong to the class of molecules called structural proteins. The ability to produce silk proteins has evolved multiple times in the arthropods, and silk secreting glands have evolved via two different pathways. The comparative data and phylogenetic analyses in this review suggest that the silk-secreting systems of spiders and insects are homologous and linked to the crural gland (origin of systemic pathway to silk production) and cuticular secretions (origin of surficial pathway to silk production) of an onychophoran-like ancestor. The evolution of silk secreting organs via a surficial pathway is possible in adult and larval hexapods, regardless of their developmental mode. Silk secretion via a systemic pathway is possible in either adult or larval hexapods, but only larval insects have dedicated silk producing glands. Spiders, however, have evolved silk producing systems via both systemic pathway and surficial pathways, and a single individual retains both throughout its lifespan. Early in the evolution of spiders, silk glands were undifferentiated, suggesting that the number of silk secreting glands of any individual was related to the spider's energetic need to produce large quantities of protein. However, the complex silk-producing systems that characterize the aerial web-building spiders and the diverse types of proteins they produce suggest that their silks reflect the diverse and increasing number of ways in which spiders use them. Because the muscular and innervated spinnerets and spigots of spiders allow them to control fiber functional properties, silk proteins represent an avenue through which animal behavior may directly affect the molecular properties of a protein.
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  • 102
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 42 (1997), S. 525-550 
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Formed of proteins, glycoproteins, and chitin microfibrils in a proteoglycan matrix, the peritrophic matrix (PM) separates the food from the midgut epithelium in most but not all insects. A PM occurs in two forms. A type I PM is delaminated from the entire midgut epithelium and, in some cases, may only be formed in response to feeding and the type of meal ingested. A type II PM is produced by a specialized region of the anterior midgut called the cardia and forms a continuous sleeve (or sleeves) that is always present. As it is positioned between food and midgut epithelium, the PM plays key roles in the intestinal biology of the insect. The PM may protect the midgut epithelium from mechanical damage and insult from pathogens and toxins; it must act as a semipermeable membrane regulating passage of molecules between the different midgut compartments; and it may separate the midgut lumen into different, physiologically significant compartments.
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  • 103
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 93-124 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Naturally occurring genetic disorders of the immune system provide many models for the study of its development and function. In a way, their analysis complements the information provided by the generation of genetic defects in mice created using homologous recombination techniques. In this review, the recent findings made in three areas are focused upon deficiencies in T cell differentiation and in T lymphocyte activation, and on the control process of peripheral immune response.
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  • 104
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    Annual Review of Immunology 15 (1997), S. 203-234 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract This review deals with membrane Fc receptors (FcR) of the immunoglobulin superfamily. It is focused on the mechanisms by which FcR trigger and regulate biological responses of cells on which they are expressed. FcR deliver signals when they are aggregated at the cell surface. The aggregation of FcR having immunoreceptor tyrosine-based activation motifs (ITAMs) activates sequentially src family tyrosine kinases and syk family tyrosine kinases that connect transduced signals to common activation pathways shared with other receptors. FcR with ITAMs elicit cell activation, endocytosis, and phagocytosis. The nature of responses depends primarily on the cell type. The aggregation of FcR without ITAM does not trigger cell activation. Most of these FcR internalize their ligands, which can be endocytosed, phagocytosed, or transcytosed. The fate of internalized receptor-ligand complexes depends on defined sequences in the intracytoplasmic domain of the receptors. The coaggregation of different FcR results in positive or negative cooperation. Some FcR without ITAM use FcR with ITAM as signal transduction subunits. The coaggregation of antigen receptors or of FcR having ITAMs with FcR having immunoreceptor tyrosine-based inhibition motifs (ITIMs) negatively regulates cell activation. FcR therefore appear as the subunits of multichain receptors whose constitution is not predetermined and which deliver adaptative messages as a function of the environment.
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  • 105
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    Annual Review of Immunology 15 (1997), S. 297-322 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract T helper lymphocytes can be divided into two distinct subsets of effector cells based on their functional capabilities and the profile of cytokines they produce. The Th1 subset of CD4+ T cells secretes cytokines usually associated with inflammation, such as IFN-gamma and TNF and induces cell-mediated immune responses. The Th2 subset produces cytokines such as IL-4 and IL-5 that help B cells to proliferate and differentiate and is associated with humoral-type immune responses. The selective differentiation of either subset is established during priming and can be significantly influenced by a variety of factors. One of these factors, the cytokine environment, has been put forward as the major variable influencing Th development and is already well reviewed by others. Instead, in the current review, we focus on some of the alternative approaches for skewing Th1/Th2 responses. Specifically, we discuss the effects on Th priming of (a) using altered peptide ligands as antigens, (b) varying the dose of antigen, and (c) altering costimulatory signals. The potential importance of each of these variables to influence immune responses to pathogens in vivo is discussed throughout.
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  • 106
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 405-431 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Epstein-Barr virus (EBV) provides one of the most informative systems with which to study cytotoxic T lymphocyte (CTL) responses in humans. The virus establishes a highly immunogenic growth-transforming infection of B lymphocytes, associated with the coordinate expression of six virus-coded nuclear antigens (EBNAs 1, 2, 3A, 3B, 3C, -LP) and two latent membrane proteins (LMPs 1 and 2). This elicits both primary and memory CT8+ CTL responses that are markedly skewed toward HLA allele-specific epitopes drawn from the EBNA3A, 3B, 3C subset of latent proteins, with reactivities to other antigens being generally much less frequent. This heirarchy of immunodominance among the different latent proteins may at least partly reflect their differential accessibility to the HLA class I-processing pathway. Furthermore, CTLs to some of the immunodominant epitopes involve highly conserved T cell receptor (TCR) usage, a level of focusing which evidence suggests could have immunopathological consequences from cross-reactive recognition of other target structures. EBV is associated with a range of human tumors, and there is increasing interest in the possibility of targeting such malignancies using virus-specific CTLs. The dramatic reversal of EBV-driven lymphoproliferations in bone marrow transplant patients following CTL infusion demonstrates the potential of this approach, and here we discuss prospects for its extension to other EBV-positive tumors in which the immunodominant EBNA3A, 3B, 3C proteins are not expressed.
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  • 107
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 535-562 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract NK1 T cells are a specialized population of alpha/beta T cells that coexpress receptors of the NK lineage and have the unique potential to very rapidly secrete large amounts of cytokines, providing early help for effector cells and regulating the Th1 or Th2 differentiation of some immune responses. NK1 T cells express a restricted TCR repertoire made of an invariant TCR alpha chain, Valpha14-Jalpha281, associated with polyclonal Vbeta8, Vbeta7, and Vbeta2 TCR beta chains. NK1 T cells recognize the products of the conserved family of MHC class I-like CD1 genes, apparently in the absence of foreign antigens. Thus, this novel regulatory pathway, which straddles the innate and the adaptive immune systems, is unique in that its activation may not require associative recognition of antigen. Here, we review the specificity and function of mouse NK1 T cells, and we discuss the relationship of this lineage to mainstream T cells and NK cells.
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  • 108
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    Annual Review of Immunology 15 (1997), S. 797-819 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Receptors for most interleukins and cytokines that regulate immune and hematopoietic systems belong to the class I cytokine receptor family. These molecules form multichain receptor complexes in order to exhibit high-affinity binding to, and mediate biological functions of, their respective cytokines. In most cases, these functional receptor complexes share common signal transducing receptor components that are also in the class I cytokine receptor family, i.e. gp130, common beta, and common gamma molecules. Interleukin-6 and related cytokines, interleukin-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1 are all pleiotropic and exhibit overlapping biological functions. Functional receptor complexes for this interleukin-6 family of cytokines share gp130 as a component critical for signal transduction. Unlike cytokines sharing common beta and common gamma chains that mainly function in hematopoietic and lymphoid cell systems, the interleukin-6 family of cytokines function extensively outside these systems as well, e.g. from the cardiovascular to the nervous system, owing to ubiquitously expressed gp130. Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. Although gp130 and its dimer partners possess no intrinsic tyrosine kinase domain, the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. This paper reviews recent progress in the study of the interleukin-6 family of cytokines and gp130.
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  • 109
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 59 (1997), S. 273-298 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract The study of gastrin continues to serve as an excellent model for gastrointestinal regulatory processes. This review highlights some recent advances in the field by outlining gastrin biosynthesis, summarizing current understanding of gastrin receptors, describing the regulation of gastrin release, and discussing the clinical implications of gastrin in the pathogenesis of peptic ulcer disease. Emphasis is on three emerging areas of gastrin research: the novel finding that one of gastrin's posttranslational processing intermediates has biological activity distinct from that of the mature peptide; elucidation of gastrin's signal transduction mechanisms that mediate the trophic effects of the peptide; and the role of gastrin in peptic ulcer disease pathogenesis secondary to Helicobacter pylori infection.
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  • 110
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 59 (1997), S. 395-412 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Angiotensin receptors are present in a number of organs and systems including heart, kidney, gonad, and placenta; pituitary and adrenal glands; the peripheral vessels, and the central nervous system. This octapeptide exerts diverse effects that include induction of cell hypertrophy and/or hyperplasia and a stimulation of hormone synthesis and ion transport in the heart, kidney, and adrenal, primarily through type 1 (AT1) receptors. In the kidney, several heterogeneous cell populations-endothelial, epithelial, and vascular-carry AT1 receptors. Some studies suggest that AT2 receptors are also functional, but the cell type carrying this receptor and the nature of its specific function have not been fully elucidated. Although studies indicate that AT1 receptors are affected in response to physiological and pathophysiological manipulations, the functional significance of these modulations remains largely uncertain. Nevertheless, recent human genetic studies indicate that polymorphisms in AT1 receptors, as well as in other angiotensin-related genes, have significant impact on organ remodeling processes of the heart and the kidney.
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  • 111
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    Annual Review of Physiology 59 (1997), S. 457-482 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Chemical activation of sensory neurons plays an important role in the somatosensory system. The actions of both endogenous mediators such as excitatory amino acids, acetylcholine, bradykinin, and ATP, as well as selective exogenous activators of nociceptive sensory neurons are reviewed. The physiological significance of these mediators in both nociception and other types of sensation are discussed.
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  • 112
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    Annual Review of Physiology 59 (1997), S. 483-504 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract M-current is a non-inactivating potassium current found in many neuronal cell types. In each cell type, it is dominant in controlling membrane excitability by being the only sustained current in the range of action potential initiation. It can be modulated by a large array of receptor types, and the modulation can occur either by suppression or enhancement. Modulation of M-current has dramatic effects on neuronal excitability. This review discusses the numerous second messenger pathways that converge on regulation of this current: in particular, two forms of regulation of the M-current, receptor-mediated modulation and the control of macroscopic current amplitude by intracellular calcium. Both types of regulation are discussed with reference to the modulation of single-channel gating properties.
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  • 113
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    Annual Review of Physiology 59 (1997), S. 437-455 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Adaptation of cells to hypertonicity often involves changes in gene expression. Since the concentration of salt in the interstitial fluid surrounding renal inner medullary cells varies with operation of the renal concentrating mechanism and generally is very high, the adaptive mechanisms of these cells are of special interest. Renal medullary cells compensate for hypertonicity by accumulating variable amounts of compatible organic osmolytes, including sorbitol, myo-inositol, glycine betaine, and taurine. In this review we consider how these solutes help relieve the stress of hypertonicity and the nature of transporters and enzymes responsible for their variable accumulation. We emphasize recent developments concerning the molecular basis for osmotic regulation of these genes, including identification and characterization of osmotic response elements. Although osmotic stresses are much smaller in other parts of the body than in the renal medulla, similar mechanisms operate throughout, yielding important physiological and pathophysiological consequences.
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  • 114
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Blood flow interactions with the vascular endothelium represent a specialized example of mechanical regulation of cell function that has important physiological and pathological cardiovascular consequences. The endothelial monolayer in vivo acts as a signal transduction interface for forces associated with flowing blood (hemodynamic forces) in the acute regulation of artery tone and chronic structural remodeling of arteries, including the pathology of atherosclerosis. Mechanisms related to spatial relationships at the cell surfaces and throughout the cell that influence flow-mediated endothelial mechanotransduction are discussed. In particular, flow-mediated ion channel activation and cytoskeletal dynamics are considered in relation to topographic analyses of the luminal and abluminal surfaces of living endothelial cells.
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  • 115
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 59 (1997), S. 573-574 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
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  • 116
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    Annual Review of Physiology 59 (1997), S. 551-571 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract External load plays a critical role in determining muscle mass and its phenotype in cardiac myocytes. Cardiac myocytes have the ability to sense mechanical stretch and convert it into intracellular growth signals, which lead to hypertrophy. Mechanical stretch of cardiac myocytes in vitro causes activation of multiple second messenger systems that are very similar to growth factor-induced cell signaling systems. Stretch of neonatal rat cardiac myocytes stimulates a rapid secretion of angiotensin II which, together with other growth factors, mediates stretch-induced hypertrophic responses in vitro. In this review, various cell signaling mechanisms initiated by mechanical stress on cardiac myocytes are summarized with emphasis on potential mechanosensing mechanisms and the relationship between mechanical loading and the cardiac renin-angiotensin system.
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  • 117
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    Annual Review of Anthropology 26 (1997), S. 73-85 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract This review is an overview of the newly developing field of language rights. It distinguishes between (a) historical/descriptive studies where language rights are treated as the resultant variable with no attempt to predict consequences, and (b) exhortatory and ideologically based studies in which language rights are considered a causal variable. An attempt at definitions follows, set within the field of language planning. Principal concerns, such as territoriality versus personality principles and individual versus collective rights, are discussed. The review ends with an argument to consider language rights as emic rights, which is to say culture-language-context-specific rights, rather than to consider linguistic human rights from a universal rights perspective which overstates issues and masks rights to as also being rights against. We need a careful exploration of the nature of language rights and their consequences.
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  • 118
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    Annual Review of Anthropology 26 (1997), S. 211-234 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract This review addresses issues of governmentality for Mesoamerica's earliest kingdoms. About 3200 years ago the Olmecs instituted stratified society based upon sacred kingship. Supervision of public works projects, the creation and deployment of monumental art, and control of ritual and ideology were the kings' principal means of governance within their kingdoms. Evidence for Olmec governance outside their region is equivocal. Olmecs may have conquered the societies of the Mazatan region, but they interacted with societies in the Mexican Highlands on a less coercive and more equitable basis.
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  • 119
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    Annual Review of Anthropology 26 (1997), S. 385-409 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract Anthropology has always involved men talking to men about men, yet until fairly recently very few within the discipline had truly examined men as men. This chapter explores how anthropologists understand, utilize, and debate the category of masculinity by reviewing recent examinations of men as engendered and engendering subjects. Beginning with descriptions of four distinct ways in which masculinity is defined and treated in anthropology, special attention is paid to the relations of difference, inequality, and women to the anthropological study of masculinities, including the awkward avoidance of feminist theory on the part of many anthropologists who study manhood. Specific topics discussed include the diverse cultural economies of masculinity, the notion of cultural regions in relation to images of manhood, male friendship, machismo, masculine embodiment, violence, power, and sexual faultlines.
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  • 120
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    Annual Review of Anthropology 26 (1997), S. 487-514 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract As a strategy of self-representation and a device of power, Europeanization is fundamentally reorganizing territoriality and peoplehood, the two principles of group identification that have shaped modern European order. It is the result of a new level and intensity of integration that has been a reaction to the destruction of this century's first and second world wars and the collapse of the cold-war division of Europe into an East and West. Driven above all by the organizational and administrative power of the European Union (EU), Europeanization is still distinct from the EU. Neither Europeanization nor the EU will replace the nation-state, which, for now, remains a superior form for organizing democratic participation and territoriality. Nonetheless, they will likely force states to yield some questions of sovereignty-above all, military, political, and economic-to the EU or other transnational bodies. Nations are now being brought into new relations with each other, creating new alliances and enmities, and are even recreating themselves. The authors explore five domains of practice where the process of Europeanization might be fruitfully studied: language, money, tourism, sex, and sport. They suggest dealing with the EU as a continental political unit of a novel order and with Europeanization pragmatically as both a vision and a process.
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  • 121
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    Annual Review of Anthropology 26 (1997), S. 25-46 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract This essay explores the continuing relevance of Marx's work in anthropological theory by examining three dimensions of his thought, concentrating on a central text in each: historical materialism (The German Ideology), the analysis of capitalism (Volume 1 of Capital), and political analysis (The Eighteenth Brumaire). Each of these dimensions is related to present-day discussions in anthropological and social theory, but the emphasis remains on an interpretation of Marx's work.
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  • 122
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    Annual Review of Anthropology 26 (1997), S. 109-128 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract The integration of gesture with speech production is described, and the various ways in which-in conversational settings-gesture functions in relation to spoken discourse are discussed. Cultural differences in gesture use are outlined, and the possible relationship between these differences and language differences, on the one hand, and the microecology of social life, on the other, are considered. Conventionalization in speech-associated gestures and in gestures that can be used without speech is discussed. Various kinds of "gesture systems" and sign languages used in speaking communities (alternate sign languages) are described along with their relationships to spoken language. Fully autonomous sign languages, as developed among the deaf, are briefly considered in regard to how signs and signing may be related to gestures and gesturing.
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  • 123
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    Annual Review of Anthropology 26 (1997), S. 291-312 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract The linguistic relativity hypothesis, the proposal that the particular language we speak influences the way we think about reality, forms one part of the broader question of how language influences thought. Despite long-standing historical interest in the hypothesis, there is relatively little empirical research directly addressing it. Existing empirical approaches are classified into three types. 1. Structure-centered approaches begin with language differences and ask about their implications for thought. 2. Domain-centered approaches begin with experienced reality and ask how different languages encode it. 3. Behavior-centered approaches begin with some practical concern and seek an explanation in language. These approaches are compared, and recent methodological improvements highlighted. Despite empirical advances, a theoretical account needs to articulate exactly how languages interpret experiences and how those interpretations influence thought. This will entail integrating theory and data concerning both the general relation of language and thought and the shaping influence of specific discursive structures and practices.
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  • 124
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    Annual Review of Anthropology 26 (1997), S. 313-335 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract Many measures in human biology that are studied as immutable traits are actually fluctuating physiological functions that adjust body systems to rapid changes in the environment. This overview discusses what has been learned about the response to the stressors inherent in continuously changing microenvironments in modern Western societies of two related physiological functions: the release of catecholamines and blood pressure. The review shows that many factors that are part of or influence lifestyle-including perception and cognitive state, the nature of the social situation, foods, stimulants and exercise-and external conditions such as temperature, continuously alter catecholamine levels and blood pressure. Because lifestyle stress may be an important selective force in human populations, studies of dynamic functions that react to it, such as catecholamine release and blood pressure, may be important in understanding the ongoing dynamics of human evolution.
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  • 125
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    Annual Review of Anthropology 26 (1997), S. 411-437 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract In the past decade, archaeologists have given considerable attention to research on gender in the human past. In this review, we attempt to acknowledge much of this diverse and abundant work from an explicitly feminist perspective. We focus on reviewing a selection of approaches to gender that are anchored to specific theoretical standpoints. In addition, we highlight several approaches that challenge an archaeology of gender that does not explicitly engage with the implications of this topic for research, practice, and interpretation. From our perspective, we suggest the value of situating gender research within an explicitly feminist framework, and we draw attention to some of the important insights for archaeology from the wider field of feminist critiques of science. Last, we draw attention to the crucial implications for the practice of archaeology.
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  • 126
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    Annual Review of Anthropology 26 (1997), S. 515-540 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract Humans are only one of the species produced by the hominoid evolutionary radiation. Common and pygmy chimpanzees (our closest relatives), gorillas, orangutans, and the lesser apes also belong to this group. In humans, patterns of genetic variation are becoming increasingly better characterized by modern molecular methods. Understanding human variation in an evolutionary context, however, requires comparison of human patterns with those of other hominoids, to reveal features shared among hominoids and those unique to humans. Genetic variation among chimpanzees, gorillas, and orangutans is beginning to be characterized, so that comparisons are now possible. From genetic data, several different kinds of information can be reconstructed, including the evolutionary relatedness of subspecies and populations, time estimates for evolutionary divergences, past population dynamics, extent of gene flow over geographical landscapes, and group social structure. Knowledge of hominoid genetic variation is also relevant to applied fields such as primate conservation and medicine.
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  • 127
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    Annual Review of Anthropology 26 (1997), S. 591-621 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract This review essay illustrates how changes in the conception of gender define the historical production of feminist ethnography in four distinct periods. In the first period (1880-1920), biological sex was seen to determine social roles, and gender was not seen as separable from sex, though it was beginning to emerge as an analytical category. The second period (1920-1960) marks the separation of sex from gender as sex was increasingly seen as indeterminative of gender roles. In the third period (1960-1980), the distinction between sex and gender was elaborated into the notion of a sex/gender system-the idea that different societies organized brute biological facts into particular gender regimes. By the contemporary period (1980-1996), critiques of "gender essentialism" (the reification of "woman" as a biological or universal category) suggest that the analytical separation between sex and gender is miscast because "sex" is itself a social category.
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    Annual Review of Nuclear and Particle Science 47 (1997), S. 67-109 
    ISSN: 0163-8998
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Notes: Abstract The development, in the early 1960s, of the dynamic nuclear polarization process in solid diamagnetic materials, doped with paramagnetic radicals, led to the use of solid polarized targets in numerous nuclear and particle physics experiments. Since then steady progress has been made in all contributing subsystems so that proton polarizations near 100% and deuteron polarizations higher than 50% have been achieved in various materials. More radiation-resistant materials, such as ammonia, have made it possible to perform experiments with high beam intensities and experiments that benefit from 4He cooling at 1K and high magnetic fields. The development of dilution refrigerators have allowed frozen spin operation so that experiments with large angular acceptance for the scattered particles have become routine. Many experiments have taken advantage of these developments and many more are being planned, especially with electromagnetic probes.
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    Annual Review of Plant Physiology and Plant Molecular Biology 48 (1997), S. 1-25 
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: The C2 oxidative photosynthetic carbon cycle plus the C3 reductive photosynthetic carbon cycle coexist. Both are initiated by Rubisco, use about equal amounts of energy, must regenerate RuBP, and result in exchanges of CO2 and O2 to establish rates of net photosynthesis, CO2 and O2 compensation points, and the ratio of CO2 and O2 in the atmosphere. These concepts evolved from research on O2 inhibition, glycolate metabolism, leaf peroxisomes, photorespiration, 18O2/16O2 exchange, CO2 concentrating processes, and a requirement for the oxygenase activity of Rubisco. Nearly 80 years of research on these topics are unified under the one process of photosynthetic carbon metabolism and its self-regulation.
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    Annual Review of Plant Physiology and Plant Molecular Biology 48 (1997), S. 297-326 
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Plant transformation is now a core research tool in plant biology and a practical tool for cultivar improvement. There are verified methods for stable introduction of novel genes into the nuclear genomes of over 120 diverse plant species. This review examines the criteria to verify plant transformation; the biological and practical requirements for transformation systems; the integration of tissue culture, gene transfer, selection, and transgene expression strategies to achieve transformation in recalcitrant species; and other constraints to plant transformation including regulatory environment, public perceptions, intellectual property, and economics. Because the costs of screening populations showing diverse genetic changes can far exceed the costs of transformation, it is important to distinguish absolute and useful transformation efficiencies. The major technical challenge facing plant transformation biology is the development of methods and constructs to produce a high proportion of plants showing predictable transgene expression without collateral genetic damage. This will require answers to a series of biological and technical questions, some of which are defined.
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    Annual Review of Plant Physiology and Plant Molecular Biology 48 (1997), S. 525-545 
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Plants cope with pathogen attacks by using mechanisms of resistance that rely both on preformed protective defenses and on inducible defenses. The latter are the most well studied, and progress is being made in determining which induced responses are responsible for limiting pathogen growth. Many plant-pathogen interactions are accompanied by plant cell death. Recent evidence suggests that this cell death is often programmed and results from an active process on the part of the host. The review considers the roles and possible mechanisms of plant cell death in response to pathogens.
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    Annual Review of Plant Physiology and Plant Molecular Biology 48 (1997), S. 641-671 
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Photosystem II (PSII) is the pigment protein complex embedded in the thylakoid membrane of higher plants, algae, and cyanobacteria that uses solar energy to drive the photosynthetic water-splitting reaction. This chapter reviews the primary, secondary, tertiary, and quaternary structures of PSII as well as the function of its constituent subunits. The understanding of in vivo organization of PSII is based in part on freeze-etched and freeze-fracture images of thylakoid membranes. These images show a resolution of about 40-50 A and so provide information mainly on the localization, heterogeneity, dimensions, and shapes of membrane-embedded PSII complexes. Higher resolution of about 15-40 A has been obtained from single particle images of isolated PSII complexes of defined and differing subunit composition and from electron crystallography of 2-D crystals. Observations are discussed in terms of the oligomeric state and subunit organization of PSII and its antenna components.
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    Annual Review of Plant Physiology and Plant Molecular Biology 48 (1997), S. 493-523 
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Infection of legume roots or stems with soil bacteria of the Rhizobiaceae results in the formation of nodules that become symbiotic nitrogen-fixing organs. Within the infected cells of these nodules, bacteria are enveloped in a membrane of plant origin, called the peribacteroid membrane (PBM), and divide and differentiate to form nitrogen-fixing bacteroids. The organelle-like structure comprised of PBM and bacteroids is termed the symbiosome, and is the basic nitrogen-fixing unit of the nodule. The major exchange of nutrients between the symbiotic partners is reduced carbon from the plant, to fuel nitrogenase activity in the bacteroid, and fixed nitrogen from the bacteroid, which is assimilated in the plant cytoplasm. However, many other metabolites are also exchanged. The metabolic interaction between the plant and the bacteroids is regulated by a series of transporters and channels on the PBM and the bacteroid membrane, and these form the focus of this review.
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    Annual Review of Plant Physiology and Plant Molecular Biology 48 (1997), S. 609-639 
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract The primary effect of the response of plants to rising atmospheric CO2 (Ca) is to increase resource use efficiency. Elevated Ca reduces stomatal conductance and transpiration and improves water use efficiency, and at the same time it stimulates higher rates of photosynthesis and increases light-use efficiency. Acclimation of photosynthesis during long-term exposure to elevated Ca reduces key enzymes of the photosynthetic carbon reduction cycle, and this increases nutrient use efficiency. Improved soil-water balance, increased carbon uptake in the shade, greater carbon to nitrogen ratio, and reduced nutrient quality for insect and animal grazers are all possibilities that have been observed in field studies of the effects of elevated Ca. These effects have major consequences for agriculture and native ecosystems in a world of rising atmospheric Ca and climate change.
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    Annual Review of Plant Physiology and Plant Molecular Biology 48 (1997), S. 673-701 
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Recent progress has been made in the genetic dissection of angiosperm shoot apical meristem (SAM) structure and function. Genes required for proper SAM development have been identified in a variety of species through the isolation of mutants. In addition, genes with expression patterns indicating they play a role in SAM function have been identified molecularly. The processes of SAM formation, self-renewal, and pattern formation within the SAM are examined with an emphasis on the contributions of recent classical and molecular genetic experiments to our understanding of this basic problem in plant developmental biology.
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    Annual Review of Environment and Resources 22 (1997), S. 155-185 
    ISSN: 1056-3466
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The distributed utility concept provides an alternate approach to guide electric utility expansion. The fundamental idea within the distributed utility concept is that particular local load increases can be satisfied at least cost by avoiding or delaying the more traditional investments in central generation capacity, bulk transmission expansion, and local transmission and distribution upgrades. Instead of these investments, the distributed utility concept suggests that investments in local generation, local storage, and local demand-side management technologies can be designed to satisfy increasing local demand at lower total cost. Critical to installation of distributed assets is knowledge of a utility system's area- and time-specific costs. This review introduces the distributed utility concept, describes an application of ATS costs to investment planning, discusses the various motivations for further study of the concept, and reviews relevant literature. Future research directions are discussed.
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    Annual Review of Environment and Resources 22 (1997), S. 217-262 
    ISSN: 1056-3466
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Assessments of global coal, oil, and natural gas occurrences usually focus on conventional hydrocarbon reserves, i.e. those occurrences that can be exploited with current technology and present market conditions. The focus on reserves seriously underestimates long-term global hydrocarbon availability. Greenhouse gas emissions based on these estimates may convey the message that the world is running out of fossil fuels, and as a result, emissions would be reduced automatically. If the vast unconventional hydrocarbon occurrences are included in the resource estimates and historically observed rates of technology change are applied to their mobilization, the potential accessibility of fossil sources increases dramatically with long-term production costs that are not significantly higher than present market prices. Although the geographical hydrocarbon resource distribution varies significantly, a regional breakdown for 11 world regions indicates that neither hydrocarbon resource availability nor costs are likely to become forces that automatically would help wean the global energy system from the use of fossil fuel during the next century.
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    Annual Review of Environment and Resources 22 (1997), S. 187-215 
    ISSN: 1056-3466
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The costs and performance of renewable energy technologies have reached the stage where the number of economical applications in developing countries is increasing, particularly in the grid and off-grid markets for electricity. The paper provides a review of policies. The conclusions are as follows. (a) Investments in renewable energy should be helped by competition and regulatory reform in the energy industry, in the electricity industry in particular, since such reforms should reduce the subsidies, which historically have permeated the countries' industries, for electricity production from fossil and hydro resources. (b) The scope for further cost reductions is appreciable in all key technologies. There are positive externalities to investment, in the sense that each generation of investments is acting to reduce the costs of future generations; such benefits ideally need to be recognized in tax and regulatory policies and in budgetary allocations for research and development (R&D) and education and training. (c) The environmental advantages of renewable energy will become more apparent as developing countries begin to introduce their environmental policies on fossil fuels. The paper also evaluates the economists' recommendations for carbon taxes, which would favor renewable energy investments. The case for such taxes has been widely ignored by policy makers. The paper suggests that (d ) a more workable and focused policy would be to accelerate the development of the "renewable energy option"; this would be economically beneficial in itself and at the same time would reduce the uncertainties and costs of responding to the challenges posed by climate change.
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    Annual Review of Environment and Resources 22 (1997), S. 263-303 
    ISSN: 1056-3466
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The quality of electric power depends on the power network topology, the amount of harmonic pollution injected in the network by nonlinear loads, and the severity of switching transients. Many of the loads encountered in modern power electronics, such as arc and induction furnaces, welders, motor drives, and many types of converters, cause a significant level of harmonic pollution and/or recurrent voltage transients. This paper describes the major sources of disturbances that affect electric service quality and explains the indices that help quantify the severity of disturbances. The loads that are most sensitive to power quality are discussed, and techniques intended to avoid or mitigate power quality problems are detailed. Finally, a brief survey of the cost of harmonic pollution and consumer outages is presented.
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    Annual Review of Environment and Resources 22 (1997), S. 305-356 
    ISSN: 1056-3466
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Geothermal energy technology is reviewed in terms of its current impact and future potential as an energy source. In general, the geothermal energy resource base is large and well distributed globally. Geothermal systems have a number of positive social characteristics (they are simple, safe, and adaptable systems with modular 1-50 MW [thermal (t) or electric (e)] plants capable of providing continuous baseload, load following, or peaking capacity) and benign environmental attributes (negligible emissions of CO2, SOx, NOx, and particulates, and modest land and water use). Because these features are compatible with sustainable growth of global energy supplies in both developed and developing countries, geothermal energy is an attractive option to replace fossil and fissile fuels. In 1997, about 7,000 MWe of base-load generating capacity and over 15,000 MWt of heating capacity from high-grade geothermal resources are in commercial use worldwide. A key question is whether these levels can grow to a point where geothermal energy is more universally available and thus have a significant impact on global energy supplies in the twenty-first century. Such an achievement will require the economic development of low-grade resources. The current status of commercial and emerging technologies for electric power production and direct heat use is reviewed for the major geothermal resources including hydrothermal, geopressured, hot dry rock, and magma. Typically, high-temperature resources (〉150oC) provide base-load generating capacity while lower-temperature resources provide energy for geothermally assisted heat pumps and for direct use in domestic, agricultural, and aquacultural heating applications. Critical development issues relating to resource quality and distribution, drilling costs, and reservoir productivity are discussed in the context of their economic impact on production costs. Advanced drilling and improved heat mining methods are suggested as approaches to increase the worldwide use of geothermal energy by reducing field development costs. With these improvements, lower-grade resources can compete in growing global energy markets that are currently controlled by abundant and low-cost fossil fuels.
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    Annual Review of Environment and Resources 22 (1997), S. 357-401 
    ISSN: 1056-3466
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The environmental agenda for mitigating climate change through international transfers of technology is linked with a diverse literature, reviewed here within a framework that combines technological, agent/agenda, and market/transaction perspectives. Literature that bears on international technology transfer for climate change mitigation is similar in many w ays for Russia and China: opportunities for energy efficiency and renewable energy, economic reform and restructuring, the difficulties enterprises face in responding to market conditions, international assistance policies, international joint ventures, market intermediation, and capacity building for market development. In both countries, capacity building means enhancing market-oriented capabilities in addition to technological capabilities. For Russia, institutional development is critical, such as new commercial legal codes and housing-sector changes beyond privatization. For China, technology policies and modernization programs significantly influence technology transfers.
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    Annual Review of Environment and Resources 22 (1997), S. 403-486 
    ISSN: 1056-3466
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Effective approaches to the management of plutonium and highly enriched uranium (HEU)-the essential ingredients of nuclear weapons-are fundamental to controlling nuclear proliferation and providing the basis for deep, transparent, and irreversible reductions in nuclear weapons stockpiles. The collapse of the Soviet Union and the ongoing dismantlement of tens of thousands of nuclear weapons are creating unprecedented stresses on the systems for managing these materials, as well as unprecedented opportunities for cooperation to improve these systems. In this article, we summarize the technical background to this situation, and the current and prospective security challenges posed by military stockpiles of these materials in the United States and Russia. We then review the programs in place to address these challenges, the progress of these programs to date, and the work remaining to be done, in five areas: (a) preventing theft and smuggling of nuclear warheads and fissile materials; (b) building a regime of monitored reductions in nuclear warhead and fissile material stockpiles; (c) ending further production of excess fissile materials; (d ) reducing stockpiles of excess fissile materials; and (e) avoiding economic collapse in the nuclear cities where substantial fractions of these materials and their guardians reside.
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    Annual Review of Environment and Resources 22 (1997), S. 487-535 
    ISSN: 1056-3466
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Codes of environmental management practice emerged as a tool of environmental policy in the late 1980s. Industry and other groups have developed codes for two purposes: to change the environmental behavior of participating firms and to increase public confidence in industry's commitment to environmental protection. This review examines five codes of environmental management practice: Responsible Care, the International Chamber of Commerce's Business Charter for Sustainable Development, ISO 14000, the CERES Principles, and The Natural Step. The first three codes have been drafted and promoted primarily by industry; the others have been developed by non-industry groups. These codes have spurred participating firms to introduce new practices, including the institution of environmental management systems, public environmental reporting, and community advisory panels. The extent to which codes are introducing a process of cultural change is considered in terms of four dimensions: new consciousness, norms, organization, and tools.
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    Annual Review of Biochemistry 66 (1997), S. 93-116 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Abstract Bacterial cell division occurs through the formation of an FtsZ ring (Z ring) at the site of division. The ring is composed of the tubulin-like FtsZ protein that has GTPase activity and the ability to polymerize in vitro. The Z ring is thought to function in vivo as a cytoskeletal element that is analogous to the contractile ring in many eukaryotic cells. Evidence suggests that the Z ring is utilized by all prokaryotic organisms for division and may also be used by some eukaryotic organelles. This review summarizes our present knowledge about the formation, function, and evolution of the Z ring in prokaryotic cell division.
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    Annual Review of Biochemistry 66 (1997), S. 337-345 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Abstract d-amino acids have been detected in a variety of peptides synthesized by animal cells. These include opiate and antimicrobial peptides from amphibian skin, neuropeptides from snail ganglia, a hormone from crustaceans, and a constituent of a spider venom. cDNA cloning has shown that at those positions where a d-amino acid is found in the end-product, a normal codon for the corresponding l-amino acid is present. This implies that the d-residues are formed from l-amino acids by a posttranslational reaction. A prototype enzyme catalyzing such a reaction has recently been isolated from the venom of the funnel web spider.
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    Annual Review of Biochemistry 66 (1997), S. 409-435 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Abstract The discovery that mutations in mitochondrial DNA (mtDNA) can be pathogenic in humans has increased interest in understanding mtDNA maintenance. The functional state of mtDNA requires a great number of factors for gene expression, DNA replication, and DNA repair. These processes are ultimately controlled by the cell nucleus, because the requisite proteins are all encoded by nuclear genes and imported into the mitochondrion. DNA replication and transcription are linked in vertebrate mitochondria because RNA transcripts initiated at the light-strand promoter are the primers for mtDNA replication at the heavy-strand origin. Study of this transcription-primed DNA replication mechanism has led to isolation of key factors involved in mtDNA replication and transcription and to elucidation of unique nucleic acid structures formed at this origin. Because features of a transcription-primed mechanism appear to be conserved in vertebrates, a general model for initiation of vertebrate heavy-strand DNA synthesis is proposed. In many organisms, mtDNA maintenance requires not only faithful mtDNA replication, but also mtDNA repair and recombination. The extent to which these latter two processes are involved in mtDNA maintenance in vertebrates is also appraised.
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    Annual Review of Biochemistry 66 (1997), S. 549-579 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Abstract The last stage of protein folding, the "endgame," involves the ordering of amino acid side-chains into a well defined and closely packed configuration. We review a number of topics related to this process. We first describe how the observed packing in protein crystal structures is measured. Such measurements show that the protein interior is packed exceptionally tightly, more so than the protein surface or surrounding solvent and even more efficiently than crystals of simple organic molecules. In vitro protein folding experiments also show that the protein is close-packed in solution and that the tight packing and intercalation of side-chains is a final and essential step in the folding pathway. These experimental observations, in turn, suggest that a folded protein structure can be described as a kind of three-dimensional jigsaw puzzle and that predicting side-chain packing is possible in the sense of solving this puzzle. The major difficulty that must be overcome in predicting side-chain packing is a combinatorial "explosion" in the number of possible configurations. There has been much recent progress towards overcoming this problem, and we survey a variety of the approaches. These approaches differ principally in whether they use ab initio (physical) or more knowledge-based methods, how they divide up and search conformational space, and how they evaluate candidate configurations (using scoring functions). The accuracy of side-chain prediction depends crucially on the (assumed) positioning of the main-chain. Methods for predicting main-chain conformation are, in a sense, not as developed as that for side-chains. We conclude by surveying these methods. As with side-chain prediction, there are a great variety of approaches, which differ in how they divide up and search space and in how they score candidate conformations.
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    Annual Review of Ecology, Evolution, and Systematics 28 (1997), S. 129-152 
    ISSN: 0066-4162
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract The diversity of organismic form has evolved nonuniformly during the history of life. Quantitative morphological studies reveal profound changes in evolutionary rates corresponding with the generation of morphological disparity at low taxonomic diversity during the early radiation of many clades. These studies have also given insight into the relative importance of genomic and ecological factors in macroevolution, the selectivity of extinction, and other issues. Important progress has been made in the development of morphological spaces that can accommodate highly disparate forms, although this area still needs more attention. Other future directions include the relationship between morphological and ecological diversification, geographic patterns in morphological diversity, and the role of morphological disparity as a causal factor in macroevolution.
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    Annual Review of Ecology, Evolution, and Systematics 28 (1997), S. 85-104 
    ISSN: 0066-4162
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Although the history of life has been characterized by intermittent episodes of radiation that can be recognized in global compilations of biodiversity, it does not necessarily follow that these episodes are caused by processes that occurred uniformly around the world. Major diversity increases could be generated by the cumulative effects of different mechanisms operating simultaneously at several geographic or environmental scales. The purpose of this review is to describe ongoing research on the manifestations, at several scales, of the Ordovician Radiation, which was among the most extensive intervals of diversification in the history of life. Through much of the period, diversity was concentrated most heavily near regions of active mountain building and volcanism; differences in diversity patterns from continent to continent, and among regions within continents, reflect this overprint. While this suggests a linkage of the Radiation and tectonic activity, this is by no means the only mediating agent. Outcrop-based research in North America has demonstrated that tectonic activity was detrimental to some biotic elements, in contrast to its effects on other organisms. Moreover, in the Great Basin of North America where the local stratigraphic record is of particularly high quality, biotic transitions characteristic of the period occurred far more rapidly than observed in global compilations of diversity, suggesting that the global rate of transition may represent the aggregate sum of transitions that occurred abruptly, but at different times, around the world. Finally, it has been demonstrated that, in concert with an increase in average age, the environmental and geographic ranges of Ordovician genera both increased significantly through the period, indicating a role for intrinsic factors in producing Ordovician biotic patterns.
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    Annual Review of Ecology, Evolution, and Systematics 28 (1997), S. 269-288 
    ISSN: 0066-4162
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract The development of theory on density-dependent natural selection has seen a transition from very general, logistic growth-based models to theories that incorporate details of specific life histories. This transition has been justified by the need to make predictions that can then be tested experimentally with specific model systems like bacteria or Drosophila. The most general models predict that natural selection should increase density-dependent rates of population growth. When trade-offs exist, those genotypes favored in low-density environments will show reduced per capita growth rates under crowded conditions and vice versa for evolution in crowded environments. This central prediction has been verified twice in carefully controlled experiments with Drosophila. Empirical research in this field has also witnessed a major transition from field-based observations and conjecture to carefully controlled laboratory selection experiments. This change in approach has permitted crucial tests of theories of density-dependent natural selection and a deeper understanding of the mechanisms of adaptation to different levels of population crowding. Experimental research with Drosophila has identified several phenotypes important to adaptation, especially at high larval densities. This same research revealed that an important trade-off occurs between competitive ability and energetic efficiency.
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    Annual Review of Ecology, Evolution, and Systematics 28 (1997), S. 317-339 
    ISSN: 0066-4162
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract A feature common to many benthic marine plants and animals is the release of propagules that serve as the organism's only mechanism of dispersal. Successful dispersal depends to a large extent on the process of settlement-the transient phase between the pelagic life of the propagule and the benthic existence of the adult. The flow of water may affect settlement on three levels: 1. Flow can act by exerting hydrodynamic forces on settling propagules. These forces may affect the propagule's encounter with the substratum, its behavior following encounter, or both. 2. Flow may provide a settlement cue that induces active behavior of motile propagules. 3. Flow may act to mediate various settlement cues (e.g. sediment load and the concentration of attractants). We discuss these three levels of flow effects as a means of examining the potential importance of flow in the settlement process, and then we explore the ecological consequences of settlement in different flow-regimes in light of the direct effects of flow and flow-derived factors.
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    Annual Review of Ecology, Evolution, and Systematics 28 (1997), S. 341-358 
    ISSN: 0066-4162
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Parasite communities are arranged into hierarchical levels of organization, covering various spatial and temporal scales. These range from all parasites within an individual host to all parasites exploiting a host species across its geographic range. This arrangement provides an opportunity for the study of patterns and structuring processes operating at different scales. Across the parasite faunas of various host species, several species-area relationships have been published, emphasizing the key role of factors such as host size or host geographical range in determining parasite species richness. When corrections are made for unequal sampling effort or phylogenetic influences, however, the strength of these relationships is greatly reduced, casting a doubt over their validity. Component parasite communities, or the parasites found in a host population, are subsets of the parasite fauna of the host species. They often form saturated communities, such that their richness is not always a reflection of that of the entire parasite fauna. The species richness of component communities is instead influenced by the local availability of parasite species and their probability of colonization. At the lowest level, infracommunities in individual hosts are subsets of the species occurring in the component community. Generally, their structure does not differ from that expected from a random assembly of available species, although comparisons with precise null models are still few. Overall studies of parasite communities suggest that the action of processes determining species richness of parasite assemblages becomes less detectable as focus shifts from parasite faunas to infracommunities.
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    Annual Review of Ecology, Evolution, and Systematics 28 (1997), S. 545-570 
    ISSN: 0066-4162
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Belowground competition occurs when plants decrease the growth, survival, or fecundity of neighbors by reducing available soil resources. Competition belowground can be stronger and involve many more neighbors than aboveground competition. Physiological ecologists and population or community ecologists have traditionally studied belowground competition from different perspectives. Physiologically based studies often measure resource uptake without determining the integrated consequences for plant performance, while population or community level studies examine plant performance but fail to identify the resource intermediary or mechanism. Belowground competitive ability is correlated with such attributes as root density, surface area, and plasticity either in root growth or in the properties of enzymes involved in nutrient uptake. Unlike competition for light, in which larger plants have a disproportionate advantage by shading smaller ones, competition for soil resources is apparently more symmetric. Belowground competition often decreases with increases in nutrient levels, but it is premature to generalize about the relative importance of above- and belowground competition across resource gradients. Although shoot and root competition are often assumed to have additive effects on plant growth, some studies provide evidence to the contrary, and potential interactions between the two forms of competition should be considered in future investigations. Other research recommendations include the simultaneous study of root and shoot gaps, since their closures may not occur simultaneously, and improved estimates of the belowground neighborhood. Only by combining the tools and perspectives from physiological ecology and population and community biology can we fully understand how soil characteristics, neighborhood structure, and global climate change influence or are influenced by plant competition belowground.
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    Annual Review of Ecology, Evolution, and Systematics 28 (1997), S. 621-658 
    ISSN: 0066-4162
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Riparian zones possess an unusually diverse array of species and environmental processes. The ecological diversity is related to variable flood regimes, geographically unique channel processes, altitudinal climate shifts, and upland influences on the fluvial corridor. The resulting dynamic environment supports a variety of life-history strategies, biogeochemical cycles and rates, and organisms adapted to disturbance regimes over broad spatial and temporal scales. Innovations in riparian zone management have been effective in ameliorating many ecological issues related to land use and environmental quality. Riparian zones play essential roles in water and landscape planning, in restoration of aquatic systems, and in catalyzing institutional and societal cooperation for these efforts.
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    Annual Review of Ecology, Evolution, and Systematics 28 (1997), S. 659-687 
    ISSN: 0066-4162
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Sexual size dimorphism (SSD) is common in both plants and animals, and current evidence suggests that it reflects the adaptation of males and females to their different reproductive roles. When species are compared within a clade, SSD is frequently found to vary with body size. This allometry is detected as betane 1, where beta is the slope of a model II regression of log(male size) on log(female size). Most frequently, beta exceeds 1, indicating that SSD increases with size where males are the larger sex, but decreases with size where females are larger, a trend formalized as "Rensch's rule." Exceptions are uncommon and associated with female-biased SSD. These trends are derived from a sample of 40 independent clades of terrestrial animals, primarily vertebrates. Their extension to plants and aquatic animals awaits quantitative assessments of allometry for SSD within these groups. Many functional hypotheses have been proposed to explain the evolution of allometry for SSD, most featuring sexual selection on males or reproductive selection on females. Of these, the hypothesis that allometry evolves because of correlational selection between the sexes appears most promising as a general model but remains untested.
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    Annual Review of Physiology 59 (1997), S. 1-21 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: This perspective tells the story of the discovery, characterization, and understanding of the surfactant system of the lung; of how investigators from many disciplines studied the system, stimulated by the demonstration of surfactant deficiency in respiratory distress syndrome of the newborn; and of how the resulting knowledge formed a basis for highly successful surfactant substitution treatment for this syndrome. The chapter includes personal reminiscences and reflections of the author and ends with a few thoughts about the present status and future prospects of this field of research.
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    Annual Review of Physiology 59 (1997), S. 23-42 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Although carotid chemosensitive glomus cells have been the most extensively studied from the vantage point of how cells sense the lack of O2, it is clear that all tissues sense O2 deprivation. In addition, all mammalian cells can trigger a cascade of events that, depending on the severity and duration of hypoxia-induced stress, can lead to permanent injury and death or to adaptation and survival. Crucial in this cascade, we believe, how the cascade is initiated, how O2 lack is detected by cells, and how these initial steps can activate further processes. In this chapter, we focus on the initial steps of O2 sensing in tissues most commonly studied, i.e. carotid glomus cells, central neurons, smooth muscle cells, and neuro-epithelial bodies of the airways. Recently it has become clear that plasma membranes of various tissues can sense the lack of O2, not only indirectly via alterations in the intracellular milieu (such as pH, Ca, ATP, etc), but also directly through an unknown mechanism that involves plasma-membrane K channels and possibly other membrane proteins. This latter mechanism is suspected to be totally independent of cytosolic changes because excised patches from plasma membranes were used in these experiments from carotid cells and neurons. There are a number of questions in this exciting area of research that pertain to the role of this plasma-membrane O2-sensing mechanism in the overall cell response, identification of all the important steps in O2 sensing, differences between O2-tolerant and O2-susceptible cells, and differences between acute and chronic cell responses to lack of O2.
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    Annual Review of Physiology 59 (1997), S. 43-62 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract The pulmonary lipofibroblast is located in the alveolar interstitium and is recognizable by its characteristic lipid droplets. During alveolar development it participates in the synthesis of extracellular matrix structural proteins, such as collagen and elastin, and as an accessory cell to the type II pneumocyte, in the synthesis of surfactant. The lipofibroblast contains cortical contractile filaments and is thereby related to the contractile interstitial cells that are normally found at the alveolar septal tips and after lung injury. The morphologic, immunologic, and biochemical characteristics of the lipofibroblast and its probable physiologic functions are reviewed. The retinoid and lipid metabolism of the lipofibroblast is compared with that of the hepatic lipocyte and the adipocyte. Although the functions of the lipofibroblast remain incompletely characterized, this cell type is emerging as an important contributor to pulmonary alveolar septal development.
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    Annual Review of Physiology 59 (1997), S. 63-88 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Cysteine proteases have traditionally been viewed as lysosomal mediators of terminal protein degradation. However, recent findings refute this limited view and suggest a more expanded role for cysteine proteases in human biology. Several newly discovered members of this enzyme class are regulated proteases with limited tissue expression, which implies specific roles in cellular physiology. These roles appear to include apoptosis, MHC class II immune responses, prohormone processing, and extracellular matrix remodeling important to bone development. The ability of macrophages and other cells to mobilize elastolytic cysteine proteases to their surfaces under specialized conditions may also lead to accelerated collagen and elastin degradation at sites of inflammation in diseases such as atherosclerosis and emphysema. The development of inhibitors of specific cysteine proteases promises to provide new drugs for modifying immunity, osteoporosis, and chronic inflammation.
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    Annual Review of Physiology 59 (1997), S. 89-144 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract In many organs and tissues, the cellular response to injury is associated with a reiteration of specific developmental processes. Studies have shown that, in response to injury, vascular wall cells in adult organisms express genes or gene products characteristic of earlier developmental states. Other genes, expressed preferentially in adult cells in vivo, are down-regulated following injurious stimuli. Complicating matters, however, are recent observations demonstrating that the vascular wall is comprised of phenotypically heterogeneous subpopulations of endothelial cells, smooth muscle cells, and fibroblasts. It is unclear how specific subsets of cells respond to injury and thus contribute to the vascular remodeling that characterizes chronic pulmonary hypertension. This review discusses vascular development in the lung and the cellular responses occurring in pulmonary hypertension; special attention is given to heterogeneity of responses within cell populations and reiteration of developmental processes.
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    Annual Review of Physiology 59 (1997), S. 145-170 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract The functional impact of ion channels in vascular endothelial cells (ECs) is still a matter of controversy. This review describes different types of ion channels in ECs and their role in electrogenesis, Ca2+ signaling, vessel permeability, cell-cell communication, mechano-sensor functions, and pH and volume regulation. One major function of ion channels in ECs is the control of Ca2+ influx either by a direct modulation of the Ca2+ influx pathway or by indirect modulation of K+ and Cl- channels, thereby clamping the membrane at a sufficiently negative potential to provide the necessary driving force for a sustained Ca2+ influx. We discuss various mechanisms of Ca2+ influx stimulation: those that activate nonselective, Ca2+-permeable cation channels or those that activate Ca2+-selective channels, exclusively or partially operated by the filling state of intracellular Ca2+ stores. We also describe the role of various Ca2+- and shear stress-activated K+ channels and different types of Cl- channels for the regulation of the membrane potential.
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    Annual Review of Physiology 59 (1997), S. 221-242 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Cholecystokinin (CCK) is an important hormonal regulator of the digestive process. CCK cells are concentrated in the proximal small intestine, and hormone is secreted into the blood upon the ingestion of food. The physiological actions of CCK include stimulation of pancreatic secretion and gallbladder contraction, regulation of gastric emptying, and induction of satiety. Therefore, in a highly coordinated manner, CCK regulates the ingestion, digestion, and absorption of nutrients. CCK is produced by two separate cell types: endocrine cells of the small intestine and various neurons in the gastrointestinal tract and central nervous system. Accordingly, CCK can function as either a hormone or a neuropeptide. This review focuses on the physiology of the CCK cell in the intestine and, in particular, on how the CCK cell is regulated to secrete its hormone product. The effects of ingested nutrients on the CCK cell and the intracellular messenger systems involved in controlling secretion are reviewed. A summary is provided of recent studies examining the electrophysiological properties of CCK cells and newly discovered proteins that act as releasing factors for CCK, which mediate feedback pathways critical for regulated secretion in the intact organism.
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    Annual Review of Physiology 59 (1997), S. 171-191 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract The past three years have seen remarkable progress in research on the molecular basis of inward rectification, with significant implications for basic understanding and pharmacological manipulation of cellular excitability. Expression cloning of the first inward rectifier K channel (Kir) genes provided the necessary breakthrough that has led to isolation of a family of related clones encoding channels with the essential functional properties of classical inward rectifiers, ATP-sensitive K channels, and muscarinic receptor-activated K channels. High-level expression of cloned channels led to the discovery that classical inward so-called anomalous rectification is caused by voltage-dependent block of the channel by polyamines and Mg2+ ions, and it is now clear that a similar mechanism results in inward rectification of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-kainate receptor channels. Knowledge of the primary structures of Kir channels and the ability to mutate them also has led to the determination of many of the structural requirements of inward rectification.
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    Annual Review of Physiology 59 (1997), S. 193-220 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Many ion transporters and channels appear to be regulated by ATP-dependent mechanisms when studied in planar bilayers, excised membrane patches, or with whole-cell patch clamp.Protein kinases are obvious candidates to mediate ATP effects, but other mechanisms are also implicated. They include lipid kinases with the generation of phosphatidylinositol phosphates as second messengers, allosteric effects of ATP binding, changes of actin cytoskeleton, and ATP-dependent phospholipases. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a possible membrane-delimited messenger that activates cardiac sodium-calcium exchange, KATP potassium channels, and other inward rectifier potassium channels. Regulation of PIP2 by phospholipase C, lipid phosphatases, and lipid kinases would thus tie surface membrane transport to phosphatidylinositol signaling. Sodium-hydrogen exchange is activated by ATP through a phosphorylation-independent mechanism, whereas ion cotransporters are activated by several protein kinase mechanisms. Ion transport in epithelium may be particularly sensitive to changes of cytoskeleton that are regulated by ATP-dependent cell signaling mechanisms.
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    Annual Review of Physiology 59 (1997), S. 243-256 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract The regulation of gastric acid secretion is achieved in the periphery by interplay between three major gastric endocrine cells: the enterochromaffin-like (ECL) cell, the gastrin or G cell, and the somatostatin or D cell. Regulation of these cells is via stimulatory or inhibitory paracrine, endocrine, and neural pathways. Upregulation of ECL function is determined by activation of CCK-B receptors, by gastrin, and by activation of beta-adrenergic receptors, as well as by acetylcholine in some (10-29%) of the cells. Gastrin and acetylcholine produce typical biphasic calcium signals. Inhibition of ECL cell histamine release and calcium signaling is produced by somatostatin acting at a type 2 receptor, histamine acting at a histamine-3 receptor, and by peptide PYY. Stimulation of ECL cells results in activation of chloride channels, and there is evidence that voltage-dependent calcium channels, along with the receptor-operated calcium channels, also are responsible for elevation of [Ca]i. Depolarization-activated K+ channels presumably restore the potential after depolarization by activation of the chloride channel. The D cell is activated by either gastrin or CCK and appears to be inhibited by acetylcholine and somatostatin. The G cell is activated by acetylcholine and gastrin-releasing peptide (GRP) and is inhibited by somatostatin. The functional integration of these three cell types is the primary determinant of the degree of stimulation of the parietal cell.
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    Annual Review of Physiology 59 (1997), S. 257-271 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract The gene encoding proglucagon, the biosynthetic precursor of glucagon, is expressed not only in the pancreatic islets but also in endocrine cells of the gastrointestinal mucosa. The proglucagon (PG)-derived peptides from the gut include glicentin (corresponding to PG 1-69); smaller amounts of oxyntomodulin (PG 33-69) and glicentin-related pancreatic polypeptide (GRPP, PG 1-30); glucagon-like peptide-1 (GLP-1, PG 78-107 amide); intervening peptide-2 (IP-2, PG 111-122 amide); and glucagon-like peptide-2 (GLP-2, PG 126-158). All are secreted into the blood in response to ingestion of carbohydrates and lipids. Only oxyntomodulin and GLP-1 have proven biological activity; oxyntomodulin possibly because it interacts (but with lower potency) with GLP-1 and glucagon receptors. GLP-1 is the most potent insulinotropic hormone known and functions as an incretin hormone. It also inhibits glucagon secretion and, therefore, lowers blood glucose. This effect is preserved in patients with non-insulin-dependent diabetes mellitus, in whom infusions of GLP-1 may completely normalize blood glucose. However, GLP-1 also potently inhibits gastrointestinal secretion and motility, and its physiological functions include mediation of the "ileal-brake" effect, i.e. the inhibition of upper gastrointestinal functions elicited by the presence of unabsorbed nutrients in the ileum. As such it may serve to regulate food intake.
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    Annual Review of Physiology 59 (1997), S. 325-347 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract This review focuses on the structure and function of the branchial chloride cell in freshwater fishes. The mitochondria-rich chloride cell is believed to be the principal site of trans-epithelial Ca2+ and Cl- influxes. Though currently debated, there is accruing evidence that the pavement cell is the site of Na+ uptake via channels linked electrically to an apical membrane vacuolar H+-ATPase (proton pump). Chloride cells perform an integral role in acid-base regulation. During conditions of alkalosis, the surface area of exposed chloride cells is increased, which serves to enhance base equivalent excretion as the rate of Cl-/HCO3- exchange is increased. Conversely, during acidosis, the chloride cell surface area is diminished by an expansion of the adjacent pavement cells. This response reduces the number of functional Cl-/HCO3- exchangers. Under certain conditions that challenge ion regulation, chloride cells proliferate on the lamellae. This response, while optimizing the Ca2+ and Cl- transport capacity of the gill, causes a thickening of the blood-to-water diffusion barrier and thus impedes respiratory gas transfer.
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    Annual Review of Physiology 59 (1997), S. 349-363 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract The majority of ovarian follicles undergo atresia, a hormonally controlled apoptotic process. Monitoring apoptotic DNA fragmentation provides a quantitative and sensitive endpoint to study the hormonal regulation of atresia in ovarian follicles. During follicle development, gonadotropins, together with local ovarian growth factors (IGF-I, EGF/TGF-alpha, basic FGF) and cytokine (interleukin-1beta), as well as estrogens, activate different intracellular pathways to rescue follicles from apoptotic demise. In contrast, TNF-alpha, Fas ligand, presumably acting through receptors with a death domain, and androgens are atretogenic factors. These diverse hormonal signals probably converge on selective intracellular pathways (including genes of the bcl-2 and ICE families) to regulate apoptosis. With a constant loss of follicles from the original stockpile, the ovary provides a unique model for studying the hormonal regulation of apoptosis.
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    Annual Review of Physiology 59 (1997), S. 299-323 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Selected teleostean (bony) fish species of the family Batrachoididae (toadfishes and midshipmen) possess high titers of all enzymes of the ornithine-urea cycle in their livers. These species have proven valuable in understanding the short-term regulation of urea synthesis, urea permeability, and transport across epithelial tissues, and how urea synthesis and excretion have evolved among vertebrates. One species in particular, the gulf toadfish (Opsanus be), has been shown to rapidly switch from ammonia excretion to urea synthesis and excretion during a variety of stress conditions (including confinement). The transition is accompanied by an upregulation of hepatic glutamine synthetase activity, and a switch to pulsatile urea excretion from the anterior end of the fish. In fact, a single day's excretion can be voided in a period of 〈3 h. Hypotheses on the environmental significance of these patterns of urea synthesis and excretion are discussed.
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    Annual Review of Physiology 59 (1997), S. 365-393 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Traditionally, steroid hormone action has been described as the modulation of nuclear transcription, thus triggering genomic events that are responsible for physiological effects. Despite early observations of rapid steroid effects that were incompatible with this theory, nongenomic steroid action has been widely recognized only recently. Evidence for these rapid effects is available for steroids of all clones and for a multitude of species and tissues. Examples of nongenomic steroid action include rapid aldosterone effects in lymphocytes and vascular smooth muscle cells, vitamin D3 effects in epithelial cells, progesterone action in human sperm, neurosteroid effects on neuronal function, and vascular effects of estrogens. Mechanisms of action are being studied with regard to signal perception and transduction, and researchers have developed a patchy sketch of a membrane receptor-second messenger cascade similar to those involved in catecholamine and peptide hormone action. Many of these effects appear to involve phospholipase C, phosphoinositide turnover, intracellular pH and calcium, protein kinase C, and tyrosine kinases. The physiological and pathophysiological relevance of these effects is unclear, but rapid steroid effects on cardiovascular, central nervous, and reproductive functions may occur in vivo. The cloning of the cDNA for the first membrane receptor for steroids should be achieved in the near future, and the physiological and clinical relevance of these rapid steroid effects can then be established.
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    Annual Review of Physiology 59 (1997), S. 413-436 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract The activity of potassium (K+) channels is intimately linked to several important transport functions in renal tubules. We review recent progress concerning the properties, site along the nephron, and physiological regulation of native K+ channels, and compare their characteristics with those of recently cloned K+ channels. We do not fully cover work on K+ channels in amphibian tubules, cell cultures, and single tubule cells and do not review K+ channels in mesangial cells.
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    Annual Review of Physiology 59 (1997), S. 621-631 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Practical limitations of the patch-clamp technique when recording mechanogated membrane ion channels are considered. Mechanical overstimulation of the patch or the cell from excessive suction/pressure protocols induces morphological and functional changes. In particular, the plasma membrane becomes decoupled from the underlying cytoskeleton to form either membrane blebs (cell-attached) or ghosts (whole cell). As a consequence, a membrane ion channel may show either a decrease or an increase in its native mechanosensitivity or even acquire mechanosensitivity. The effect varies with ion channel and cell type and presumably arises because of a disruption of membrane-cytoskeleton interactions. We consider that such disruptions are a pathological consequence of excessive mechanical stress, either during or after seal formation, rather than an immutable consequence of patch-clamp recording. By careful attention to the suction/pressure protocols during sealing and throughout recording, such artifacts can be avoided.
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    Annual Review of Physiology 59 (1997), S. 601-619 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Osmoreceptors regulate sodium and water balance in a manner that maintains the osmotic pressure of the extracellular fluid (ECF) near an ideal set point. In rats, the concerted release of oxytocin and vasopressin, which is determined by the firing rate of magnocellular neurosecretory cells (MNCs), plays a key role in osmoregulation through the effects of natriuresis and diuresis. Changes in excitatory synaptic drive, derived from osmosensitive neurons in the organum vasculosum lamina terminalis (OVLT), combine with endogenously generated osmoreceptor potentials to modulate the firing rate of MNCs. The cellular basis for osmoreceptor potentials has been characterized using patch-clamp recordings and morphometric analysis in MNCs isolated from the supraoptic nucleus of the adult rat. In these cells, stretch-inactivated cationic channels transduce osmotically evoked changes in cell volume into functionally relevant changes in membrane potential. The experimental details of these mechanisms are reviewed in their physiological context.
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    Annual Review of Physiology 59 (1997), S. 659-689 
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    Topics: Medicine , Biology
    Notes: Abstract Genetic and molecular studies of touch avoidance in the nematode Caenorhabditis elegans have resulted in a molecular model for a mechanotransducing complex. mec-4 and mec-10 encode proteins hypothesized to be subunits of a mechanically gated ion channel that are related to subunits of the vertebrate amiloride-sensitive epithelial Na+ channel. Products of mec-5, a novel collagen, and mec-9, a protein that includes multiple Kunitz-type protease inhibitor repeats and EGF repeats, may interact with the channel in the extracellular matrix. Inside the cell, specialized 15-protofilament microtubules composed of mec-12alpha-tubulin and mec-7beta-tubulin may be linked to the mechanosensitive channel by stomatin-homologous MEC-2. MEC-4 and MEC-10 are members of a large family of C. elegans proteins, the degenerins. Two other degenerins, UNC-8 and DEL-1, are candidate components of a stretch-sensitive channel in motor neurons. Implications for advancing understanding of mechanotransduction in other systems are discussed.
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    Annual Review of Anthropology 26 (1997), S. 185-210 
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract Fossils pose special problems for making phylogenetic and functional inferences about evolution. One reason is that bones have numerous functions and grow through a variety of processes, some of which are under strong genetic control, but many of which are highly influenced by external stimuli. Analyses of the angular kinetics, cross-sectional geometries, and microstructural properties of bones reveal information not only about the forces generated by habitual activities but also about osteogenic responses to such forces. Consequently, comparisons of osseous characters are at best an indirect and frequently misleading source of systematic information. By integrating functional and phylogenetic studies of the skeleton with analyses of how bones develop, we may find a useful solution to these problems.
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    Annual Review of Anthropology 26 (1997), S. 129-161 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract Between 100 BCE and 200 CE, the city of Teotihuacan grew rapidly, most of the Basin of Mexico population was relocated in the city, immense civic-religious structures were built, and symbolic and material evidence shows the early importance of war. Rulers were probably able and powerful. Subsequently the city did not grow, and government may have become more collective, with significant constraints on rulers' powers. A state religion centered on war and fertility deities presumably served elite interests, but civic consciousness may also have been encouraged. A female goddess was important but probably not as pervasive as has been suggested. Political control probably did not extend beyond central Mexico, except perhaps for some outposts, and the scale and significance of commerce are unclear. Teotihuacan's prestige, however, spread widely in Mesoamerica, manifested especially in symbols of sacred war, used for their own ends by local elites.
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    Annual Review of Anthropology 26 (1997), S. 163-183 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract The study of colonialism erases the boundaries between anthropology and history or literary studies, and between the postcolonial present and the colonial past. From the standpoint of anthropology, it is also reflexive, addressing the colonial use and formation of ethnography and its supporting practices of travel. Since the 1960s, the study of colonialism has increasingly presented a view of colonialism as struggle and negotiation, analyzing how the dichotomous representations that Westerners use for colonial rule are the outcome of much more murky and complex practical interactions. By thus treating Western governmentality as emergent and particular, it is rewriting our histories of the present.
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    Annual Review of Anthropology 26 (1997), S. 235-261 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: Abstract Pastoralist societies face more threats to their way of life now than at any previous time. Population growth; loss of herding lands to private farms, ranches, game parks, and urban areas; increased commoditization of the livestock economy; out-migration by poor pastoralists; and periodic dislocations brought about by drought, famine, and civil war are increasing in pastoralist regions of the world. Mongolia and China, however, have seen a revitalization of pastoral production with decollectivization. This review examines problems of pastoral governance and development including the "tragedy of the commons" debate, threats to common property rights, the effects of commercial ranching on pastoral economies, decollectivization in the former socialist countries, and the current state of development policies of Western donor countries. Case examples from the Maasai and Barabaig of East Africa and pastoralists of Mongolia and China illustrate these changes.
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    Annual Review of Neuroscience 20 (1997), S. 1-24 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Regionalization of the cerebral cortex occurs during development by the formation of anatomically and functionally discrete areas of the brain. Descriptive evidence based on expression of molecules and structural features suggests that an early parcelation of the cerebral wall may occur during fetal development. Experimental strategies using tissue transplants and cell culture models have explored the nature of the timing of areal specification. New signaling systems displaying the sensitivity of precursor cells to environmental cues that define the fate of neurons destined for specific areas of the cortex have been discovered. Studies in the field now suggest mechanisms of regulating cell phenotype in the cortex that are common to all parts of the neuraxis.
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    Annual Review of Neuroscience 20 (1997), S. 25-42 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The dorsal premotor cortex is a functionally distinct cortical field or group of fields in the primate frontal cortex. Anatomical studies have confirmed that most parietal input to the dorsal premotor cortex originates from the superior parietal lobule. However, these projections arise not only from the dorsal aspect of area 5, as has long been known, but also from newly defined areas of posterior parietal cortex, which are directly connected with the extrastriate visual cortex. Thus, the dorsal premotor cortex receives much more direct visual input than previously accepted. It appears that this fronto-parietal network functions as a visuomotor controller-one that makes computations based on proprioceptive, visual, gaze, attentional, and other information to produce an output that reflects the selection, preparation, and execution of movements.
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    Annual Review of Neuroscience 20 (1997), S. 43-60 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract During early vertebrate development, the cells of the ectoderm choose between two possible fates: neural and epidermal. The process of neural induction was discovered nearly 70 years ago in vertebrates, and molecular analyses in recent years using Xenopus laevis embryos have identified several secreted factors with direct neural-inducing ability. There is considerable evidence that the mechanism of neuralization by these inducing factors is under inhibitory control and involves derepression. This review focuses on factors involved in the specification of neural fate within the frame of the default model of neural induction.
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    Annual Review of Neuroscience 20 (1997), S. 61-90 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The concept of developmental compartments originated in studies of Drosophila embryogenesis. This review examines the hypothesis that the modular structure of the vertebrate cerebellum is strongly analogous to this earlier scheme. The pattern of cerebellar development, the adult circuitry, a variety of molecular markers expressed in specific subdivisions, and the phenotypes of several neurological mutations all provide abundant evidence that the vertebrate cerebellum is organized into modules. We present the case that, as a group, these markers reveal distinct boundaries that partition the cerebellum into true developmental compartments. Although this reductionist viewpoint advances our understanding of cerebellar organization, the relationship between these compartments and the functional behavior of the cerebellum remains a mystery.
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  • 183
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    Annual Review of Neuroscience 20 (1997), S. 91-123 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Potassium channels contribute to the excitability of neurons and signaling in the nervous system. They arise from multiple gene families including one for voltage-gated potassium channels and one for inwardly rectifying potassium channels. Features of potassium permeation, channel gating and regulation, and subunit interaction have been analyzed. Potassium channels of similar design have been found in animals ranging from jellyfish to humans, as well as in plants, yeast, and bacteria. Structural similarities are evident for the pore-forming alpha subunits and for the beta subunits, which could potentially regulate channel activity according to the level of energy and/or reducing power of the cell.
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  • 184
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    Annual Review of Neuroscience 20 (1997), S. 157-184 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Recently, dozens of mutant mice generated with gene targeting or transgenic technologies have been shown to exhibit a distinct set of impairments in the brain and behavior. In this review, we discuss how studies of mutant mice have helped elucidate the mechanisms that underlie synaptic plasticity and the relationship of these synaptic mechanisms to the activity-dependent phase of neural development and learning and memory. We focus on the recent progress in the analysis of whisker-related pattern formation, elimination of climbing fibers, long-term potentiation, long-term depression, and various learning and memory tasks in mutant mice.
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  • 185
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    Annual Review of Neuroscience 20 (1997), S. 125-156 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Classical neurotransmitters are synthesized in the cytoplasm, so they require transport into secretory vesicles for regulated exocytotic release. Previous work has identified distinct vesicular transport activities for the different classical transmitters, and all depend on the H+-electrochemical gradient across the vesicle membrane but differ in the extent to which they rely on the chemical and electrical components of this gradient. Drugs that interfere with vesicular amine transport have implicated this activity in psychiatric disease. Selection for a cDNA encoding vesicular amine transport in the neurotoxin MPP+ also implicates the activity in Parkinson's disease. Molecular cloning of vesicular monoamine transporters shows sequence similarity to bacterial antibiotic resistance proteins, supporting a role for transport in detoxification and defining a novel mammalian gene family that now also includes a transporter for acetylcholine. Current work focuses on the mechanism of transport and the role that regulation of activity and its subcellular localization have in transmitter release, behavior, and neural degeneration.
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    Annual Review of Neuroscience 20 (1997), S. 185-215 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Thalamocortical activity exhibits two distinct states: (a) synchronized rhythmic activity in the form of delta, spindle, and other slow waves during EEG-synchronized sleep and (b) tonic activity during waking and rapid-eye-movement sleep. Spindle waves are generated largely through a cyclical interaction between thalamocortical and thalamic reticular neurons involving both the intrinsic membrane properties of these cells and their anatomical interconnections. Specific alterations in the interactions between these cells can result in the generation of paroxysmal events resembling absence seizures in children. The release of several different neurotransmitters from the brain stem, hypothalamus, basal forebrain, and cerebral cortex results in a depolarization of thalamocortical and thalamic reticular neurons and an enhanced excitability in many cortical pyramidal cells, thereby suppressing the generation of sleep rhythms and promoting a state that is conducive to sensory processing and cognition.
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  • 187
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    Annual Review of Neuroscience 20 (1997), S. 217-244 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The development of techniques to record from populations of neurons has made it possible to ask questions concerning the encoding of task-relevant information in awake, behaving animals. The issue of how groups of neurons within different brain structures register and retrieve representations of behaviorally significant events can now be addressed using multineuron-recording techniques. This review examines recent studies employing simultaneous recording of ten or more individual neurons in the mammalian brain. A major issue discussed is whether ensemble information content reconstructed from single-neuron recordings may be underestimated if compared to ensembles where those same neurons were recorded simultaneously. The mechanics of ensemble information encoding in the hippocampus is illustrated from population statistical analyses of ensemble activity during performance of a delay task. Detailed descriptions of methods of extracting ensemble information, as well as cross-correlational analyses, are discussed in the context of emergent issues regarding interpretation of ensemble data.
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    Annual Review of Neuroscience 20 (1997), S. 245-267 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract A growing family of genes that share homology with the bcl-2 proto-oncogene is involved in the regulation of cell death. Many of these proteins show widespread expression and are expressed in the nervous system in developing and adult organisms. A physiologic role for Bcl-2 and Bcl-x in neuron survival has been shown. In addition, these proteins have been shown to protect neurons from a wide array of toxic insults. In this review, we discuss the Bcl-2 family of proteins with regard to their structure and interactions. We then discuss the role of apoptotic cell death in the development of the nervous system and as a response to neuronal injury. Lastly, we discuss the evidence for a role for these cell death regulators in neuronal death decisions.
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    Annual Review of Neuroscience 20 (1997), S. 269-301 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract RNA molecules synthesized in the nucleus are transported to their sites of function throughout the eukaryotic cell by specific transport pathways. This review focuses on transport of messenger RNA, small nuclear RNA, ribosomal RNA, and transfer RNA between the nucleus and the cytoplasm. The general molecular mechanisms involved in nucleocytoplasmic transport of RNA are only beginning to be understood. However, during the past few years, substantial progress has been made. A major theme that emerges from recent studies of RNA transport is that specific signals mediate the transport of each class of RNA, and these signals are provided largely by the specific proteins with which each RNA is associated.
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    Annual Review of Neuroscience 20 (1997), S. 331-353 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The mechanisms by which human speech is processed in the brain are reviewed from both behavioral and neurobiological perspectives. Special consideration is given to the separation of speech processing as a complex acoustic-processing task versus a linguistic task. Relevant animal research is reviewed, insofar as these data provide insight into the neurobiological basis of complex acoustic processing in the brain.
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    Annual Review of Neuroscience 20 (1997), S. 303-330 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Recent experiments are reviewed that indicate that sensory signals from many modalities, as well as efference copy signals from motor structures, converge in the posterior parietal cortex in order to code the spatial locations of goals for movement. These signals are combined using a specific gain mechanism that enables the different coordinate frames of the various input signals to be combined into common, distributed spatial representations. These distributed representations can be used to convert the sensory locations of stimuli into the appropriate motor coordinates required for making directed movements. Within these spatial representations of the posterior parietal cortex are neural activities related to higher cognitive functions, including attention. We review recent studies showing that the encoding of intentions to make movements is also among the cognitive functions of this area.
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    Annual Review of Neuroscience 20 (1997), S. 355-373 
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Manic depressive illness is a common and frequently debilitating familial psychiatric disorder. Efforts to understand the mechanisms of inheritance have been hindered by the complexity of the phenotype, which may range from benign mood swings to chronic psychosis, and by apparently nonmendelian modes of transmission. Early reports of linkage to chromosomal loci have fallen into doubt; however they have helped encourage the development of more sophisticated methods for analyzing complex phenotypes. Using such methods, linkage of manic depressive illness to loci on chromosome 18 has been reported and apparently replicated, and work is proceeding to identify genes associated with what is probably a genetically heterogeneous set of disorders. As molecular mechanisms of inheritance are elucidated, it will be important to consider the ethical implications of genetic testing in a clinically and genetically complex disorder such as manic depressive illness.
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    Annual Review of Neuroscience 20 (1997), S. 429-458 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Motor neurons influence the expression and the distribution of acetylcholine receptors in skeletal muscle. Molecules that mediate this carefully choreographed interaction have recently been identified. One of them, ARIA, is a polypeptide purified from chicken brain on the basis of its ability to stimulate the synthesis of muscle acetylcholine receptors. The predicted amino acid sequence suggests that ARIA is synthesized as a transmembrane precursor protein and that it is a member of a family of ligands that activate receptor tyrosine kinases related to the epidermal growth factor receptor. Certain features of the ligand family (the neuregulins) and their receptors (erbBs) are reviewed. Evidence that ARIA plays an important role at developing and mature neuromuscular junctions is discussed.
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    Annual Review of Neuroscience 20 (1997), S. 375-397 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Physiological activation of the magnocellular hypothalamo-neurohypophysial system induces a coordinated astrocytic withdrawal from between the magnocellular somata and the parallel-projecting dendrites of the supraoptic nucleus. Neural lobe astrocytes release engulfed axons and retract from their usual positions along the basal lamina. Occurring on a minutes-to-hours time scale, these changes are accompanied by increased direct apposition of both somatic and dendritic membrane, the formation of dendritic bundles, the appearance of novel multiple synapses in both the somatic and dendritic zones, and increased neural occupation of the perivascular basal lamina. Reversal, albeit with varying time courses, is achieved by removing the activating stimuli. Additionally, activation results in interneuronal coupling increases that are capable of being modulated synaptically via second messenger-dependent mechanisms. These changes appear to play important roles in control and coordination of oxytocin and vasopressin release during such conditions as lactation and dehydration.
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    Annual Review of Neuroscience 20 (1997), S. 399-427 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract A prerequisite for the maintenance of homeostasis in a living organism is fine-tuned communication between different cells. The majority of extracellular signaling molecules, such as hormones and neurotransmitters, interact with a three-protein transmembrane signaling system consisting of a receptor, a G protein, and an effector. These single components interact sequentially and reversibly. Considering that hundreds of G-protein-coupled receptors interact with a limited repertoire of G proteins, the question of coupling specificity is worth considering. G-protein-mediated signal transduction is a complex signaling network with diverging and converging transduction steps at each coupling interface. The recent realization that classical signaling pathways are intimately intertwined with growth-factor-signaling cascades adds another level of complexity. Elaborate studies have significantly enhanced our knowledge of the functional anatomy of G-protein-coupled receptors, and the concept has emerged that receptor function can be modulated with high specificity by coexpressed receptor fragments. These results may have significant clinical impact in the future.
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    Annual Review of Neuroscience 20 (1997), S. 459-481 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The neural substrate underlying learned vocal behavior in songbirds provides a textbook illustration of anatomical localization of function for a complex learned behavior in vertebrates. The song-control system has become an important model for studying neural systems related to learning, behavior, and development. The song system of zebra finches is characterized by a heightened capacity for both neural and behavioral change during development and has taught us valuable information regarding sensitive periods, rearrangement of synaptic connections, topographic specificity, cell death and neurogenesis, experience-dependent neural plasticity, and sexual differentiation. The song system differs in some interesting ways from some well-studied mammalian model systems and thus offers fresh perspectives on specific theoretical issues. In this highly selective review, we concentrate on two major questions: What are the developmental changes in the song system responsible for song learning and the restriction of learning to a sensitive period, and what factors explain the highly sexually dimorphic development of this system? We discuss the important role of sex steroid hormones and of neurotrophins in creating a male-typical neural song circuit (which can learn to produce complex vocalizations) instead of a reduced, female-typical song circuit that does not produce learned song.
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    Annual Review of Neuroscience 20 (1997), S. 483-532 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosophila melanogaster, and Caenorhabditis elegans suggest that Pax-6 homologues share conserved functions. In this review, we present recent data on the structural and functional characterization of Pax-6 homologues from species of different animal phyla. We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems.
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    Annual Review of Neuroscience 20 (1997), S. 567-594 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Mechanosensation, the transduction of mechanical forces into a cellular electrochemical signal, enables living organisms to detect touch; vibrations, such as sound; accelerations, including gravity; body movements; and changes in cellular volume and shape. Ion channels directly activated by mechanical tension are thought to mediate mechanosensation in many systems. Only one channel has been cloned that is unequivocably mechanically gated: the MscL channel in bacteria. Genetic screens for touch-insensitive nematodes or flies promise to identify the proteins that constitute a mechanosensory apparatus in eukaryotes. In Caenorhabditis elegans, the mec genes thus identified encode molecules for a candidate structure, which includes a "degenerin" channel tethered to specialized extracellular and intracellular structural proteins. In hair cells of the inner ear, evidence suggests that an extracellular tip link pulls on a channel, which attached intracellularly to actin via a tension-regulating myosin 1beta. The channel and the tip link have not been cloned. Because degenerins and MscL homologs have not been found outside of nematodes and prokaryotes, respectively, and because intracellular and extracellular accessory structures apparently differ among organs and species, it may be that mechanosensory channel complexes evolved multiple times.
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    Annual Review of Neuroscience 20 (1997), S. 533-566 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Geoffrey Harris is responsible for our view that the brain controls the endocrine system by an exquisitely regulated pattern of synthesis and release of individual members of a family of peptide hormones. These hormones are carried through a portal vascular system that passes from the hypothalamus to the pituitary gland, where they selectively regulate the secretion of the six anterior pituitary hormones. This family of hypothalamic hormones is highly conserved in all vertebrates, including humans. They are essential for all aspects of reproduction-courtship, mating, pregnancy and young rearing-and they are responsible for the seasonal regulation of breeding. The hypothalamic control mechanism for reproduction is sexually dimorphic, with a basic female pattern that becomes masculinized under the influence of specific steroid hormones acting during development. Other members of the hypothalamic hormone family specifically regulate the secretion of pituitary growth hormone and the anterior pituitary hormones controlling the functions of the thyroid and adrenal glands. The secretion of the hypothalamic hormones is itself regulated by the feedback of the target gland hormones (such as estrogen and progesterone), which concurrently act on the brain to elicit appropriate behavior patterns. The hypothalamo-hypophysial axis plays a crucial role in the struggle for the survival of the species. By bringing the endocrine system under the control of the brain, it allows access to external environmental inputs, learned behavior patterns, and the whole of the central integrative machinery needed for the bodily functions to be sensitively and optimally adapted to the ever-changing challenges and opportunities in the outside world.
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    Annual Review of Neuroscience 20 (1997), S. 595-631 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Olfaction begins with the transduction of the information carried by odor molecules into electrical signals in sensory neurons. The activation of different subsets of sensory neurons to different degrees is the basis for neural encoding and further processing of the odor information by higher centers in the olfactory pathway. Recent evidence has converged on a set of transduction mechanisms, involving G-protein-coupled second-messenger systems, and neural processing mechanisms, involving modules called glomeruli, that appear to be adapted for the requirements of different species. The evidence is highlighted in this review by focusing on studies in selected vertebrates and in insects and crustaceans among invertebrates. The findings support the hypothesis that olfactory transduction and neural processing in the peripheral olfactory pathway involve basic mechanisms that are universal across most species in most phyla.
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