ALBERT

Description: Although there is general agreement that a high degree of variability exists between subjects in their autonomic nervous system responses to motion sickness stimulation, very little evidence exists that examines the reproducibility of autonomic responses within subjects during motion sickness stimulation. Our objectives were to examine the reliability of autonomic responses and symptom levels across five testing occasions using the (1) final minute of testing, (2) change in autonomic response and the change in symptom level, and (3) strength of the relationship between the change in symptom level and the change in autonomic responses across the entire motion sickness test. The results indicate that, based on the final minute of testing, the autonomic responses of heart rate, blood volume pulse, and respiration rate are moderately stable across multiple tests. Changes in heart rate, blood volume pulse, respiration rate, and symptoms throughout the test duration are less stable across the tests. Finally, autonomic responses and symptom levels are significantly related across the entire motion sickness test.

Description: Hind limb elevation of the growing rat provides a good model for the skeletal changes that occur during space flight. In this model the bones of the forelimbs (normally loaded) are used as an internal control for the changes that occur in the unloaded bones of the hind limbs. Previous studies have shown that skeletal unloading of the hind limbs results in a transient reduction of bone formation in the tibia and femur, with no change in the humerus. This fall in bone formation is accompanied by a fall in serum osteocalcin (bone Gla protein, BGP) and bone BGP messenger RNA (mRNA) levels, but a rise in bone insulin-like growth factor-I (IGF-I) protein and mRNA levels and resistance to the skeletal growth-promoting actions of IGF-I. To determine whether skeletal unloading also induced resistance to GH, we evaluated the response of the femur and humerus of sham and hypophysectomized rats, control and hind limb elevated, to GH (two doses), measuring mRNA levels of IGF-I, BGP, rat bone alkaline phosphatase (RAP), and alpha 1(1)-procollagen (coll). Hypophysectomy (HPX) decreased the mRNA levels of IGF-I, BGP, and coll in the femur, but was either less effective or had the opposite effect in the humerus. GH at the higher dose (500 micrograms/day) restored these mRNA levels to or above the sham control values in the femur, but generally had little or no effect on the humerus. RAP mRNA levels were increased by HPX, especially in the femur. The lower dose of GH (50 micrograms/day) inhibited this rise in RAP, whereas the higher dose raised the mRNA levels and resulted in the appearance of additional transcripts not seen in controls. As for the other mRNAs, RAP mRNA in the humerus was less affected by HPX or GH than that in the femur. Hind limb elevation led to an increase in IGF-I, coll, and RAP mRNAs and a reduction in BGP mRNA in the femur and either had no effect or potentiated the response of these mRNAs to GH. We conclude that GH stimulates a number of markers of bone formation by raising their mRNA levels, and that skeletal unloading does not block this response, but the response varies substantially from bone to bone.

Description: Eye movements have attracted an unusually large number of researchers from many disparate fields, especially over the past 35 years. The lure of this system stemmed from its apparent simplicity of description, measurement, and analysis, as well as the promise of providing a "window in the mind." Investigators in areas ranging from biological control systems and neurological diagnosis to applications in advertising and flight simulation expected eye movements to provide clear indicators of what the sensory-motor system was accomplishing and what the brain found to be of interest. The parallels between compensatory eye movements and perception of spatial orientation have been a subject for active study in visual-vestibular interaction, where substantial knowledge has accumulated through experiments largely guided by the challenge of proving or disproving model predictions. Even though oculomotor control has arguably benefited more from systems theory than any other branch of motor control, many of the original goals remain largely unfulfilled. This paper considers some of the promising potential benefits of eye movement research and compares accomplishments with anticipated results. Four topics are considered in greater detail: (i) the definition of oculomotor system input and output, (ii) optimization of the eye movement system, (iii) the relationship between compensatory eye movements and spatial orientation through the "internal model," and (iv) the significance of eye movements as measured in (outer) space.

Description: Intramuscular pressures, electromyography (EMG) and torque generation during isometric, concentric and eccentric maximal isokinetic muscle activity were recorded in 10 healthy volunteers. Pressure and EMG activity were continuously and simultaneously measured side by side in the tibialis anterior and soleus muscles. Ankle joint torque and position were monitored continuously by an isokinetic dynamometer during plantar flexion and dorsiflexion of the foot. The increased force generation during eccentric muscular activity, compared with other muscular activity, was not accompanied by higher intramuscular pressure. Thus, this study demonstrated that eccentric muscular activity generated higher torque values for each increment of intramuscular pressure. Intramuscular pressures during antagonistic co-activation were significantly higher in the tibilis anterior muscle (42-46% of maximal agonistic activity) compared with the soleus muscle (12-29% of maximal agonistic activity) and was largely due to active recruitment of muscle fibers. In summary, eccentric muscular activity creates higher torque values with no additional increase of the intramuscular pressure compared with concentric and isometric muscular activity.

Description: The effects of atrial natriuretic peptide (ANP), vasopressin (AVP) and angiotensin (ANG) on blood and intraocular pressures of pentobarbital anesthetized rats were evaluated following intravenous, intracerebroventricular or anterior chamber routes of administration. Central injections did not affect intraocular pressure. Equipressor intravenous infusions of ANG raised, whereas AVP decreased, intraocular pressure. Direct infusions of a balanced salt solution (0.175 microliter/min) raised intraocular pressure between 30 and 60 min. Adding ANG or ANP slightly reduced this solvent effect but AVP was markedly inhibitory. An AVP-V1 receptor antagonist reversed the blunting of the solvent-induced rise by the peptide, indicating receptor specificity. Acetazolamide pretreatment lowered intraocular pressure, but the solvent-induced rise in intraocular pressure and inhibition by AVP still occurred without altering the temporal pattern. Thus, these effects appear unrelated to aqueous humor synthesis rate. The data support the possibility of intraocular pressure regulation by peptides acting from the blood and aqueous humor.

Description: Bone mass is the primary, although not the only, determinant of fracture. Over the past few years a number of noninvasive techniques have been developed to more sensitively quantitate bone mass. These include single and dual photon absorptiometry (SPA and DPA), single and dual X-ray absorptiometry (SXA and DXA) and quantitative computed tomography (QCT). While differing in anatomic sites measured and in their estimates of precision, accuracy, and fracture discrimination, all of these methods provide clinically useful measurements of skeletal status. It is the intent of this review to discuss the pros and cons of these techniques and to present the new applications of ultrasound (US) and magnetic resonance (MRI) in the detection and management of osteoporosis.

Description: Historically the major impediment to radiation cataract follow-up has been the necessarily subjective nature of assessing the degree of lens transparency. This has spurred the development of instruments which produce video images amenable to digital analysis. One such system, the Zeiss Scheimpflug slit lamp measuring system (SLC), was incorporated into our ongoing studies of radiation cataractogenesis. It was found that the Zeiss SLC measuring system has high resolution and permits the acquisition of reproducible images of the anterior segment of the eye. Our results, based on about 650 images of lenses followed over a period of 91 weeks of radiation cataract development, showed that the changes in the light scatter of the lens correlated well with conventional assessment of radiation cataracts with the added advantages of objectivity, permanent and transportable records and linearity as cataracts become more severe. This continuous data acquisition, commencing with cataract onset, can proceed through more advanced stages. The SLC exhibits much greater sensitivity reflected in a continuously progressive severity thereby avoiding the artifactual plateaus in staging which occur using conventional scoring methods.

Description: We measured the linear vestibulo-ocular reflex (LVOR) and vergence, using binocular search coils, in 3 humans. The subjects were accelerated sinusoidally at 0.5 Hz and 0.2 g peak acceleration, in complete darkness, while performing three different tasks: i) mental arithmetic; ii) tracking a remembered target at either 0.34 m or 0.14 m distance; and iii) maintaining vergence at either of these distances by means of audio biofeedback based on vergence. Subjects could control vergence using the audio feedback; there was greater convergence with the near audio target. However, there was no significant difference in vergence between the near and far remembered target conditions. With audio feedback, the amplitude of smooth tracking was not consistently different for the near and the far conditions. However, the amplitude of tracking (saccades and smooth component) in the remembered target conditions was greater for near than for far targets. These results suggest that linear VOR amplitude is not determined by vergence alone.

Description: This study reports on the short-term in vivo precision and absolute measurements of three combinations of whole-body scan modes and analysis software using a Hologic QDR 2000 dual-energy X-ray densitometer. A group of 21 normal, healthy volunteers (11 male and 10 female) were scanned six times, receiving one pencil-beam and one array whole-body scan on three occasions approximately 1 week apart. The following combinations of scan modes and analysis software were used: pencil-beam scans analyzed with Hologic's standard whole-body software (PB scans); the same pencil-beam analyzed with Hologic's newer "enhanced" software (EPB scans); and array scans analyzed with the enhanced software (EA scans). Precision values (% coefficient of variation, %CV) were calculated for whole-body and regional bone mineral content (BMC), bone mineral density (BMD), fat mass, lean mass, %fat and total mass. In general, there was no significant difference among the three scan types with respect to short-term precision of BMD and only slight differences in the precision of BMC. Precision of BMC and BMD for all three scan types was excellent: 〈 1% CV for whole-body values, with most regional values in the 1%-2% range. Pencil-beam scans demonstrated significantly better soft tissue precision than did array scans. Precision errors for whole-body lean mass were: 0.9% (PB), 1.1% (EPB) and 1.9% (EA). Precision errors for whole-body fat mass were: 1.7% (PB), 2.4% (EPB) and 5.6% (EA). EPB precision errors were slightly higher than PB precision errors for lean, fat and %fat measurements of all regions except the head, although these differences were significant only for the fat and % fat of the arms and legs. In addition EPB precision values exhibited greater individual variability than PB precision values. Finally, absolute values of bone and soft tissue were compared among the three combinations of scan and analysis modes. BMC, BMD, fat mass, %fat and lean mass were significantly different between PB scans and either of the EPB or EA scans. Differences were as large as 20%-25% for certain regional fat and BMD measurements. Additional work may be needed to examine the relative accuracy of the scan mode/software combinations and to identify reasons for the differences in soft tissue precision with the array whole-body scan mode.

Description: A mathematical model has been developed to help explain human multi-sensory interactions. The most important constituent of the model is the hypothesis that the nervous system incorporates knowledge of sensory dynamics into an "internal model" of these dynamics. This internal model allows the nervous system to integrate the sensory information from many different sensors into a coherent estimate of self-motion. The essence of the model is unchanged from a previously published model of monkey eye movement responses; only a few variables have been adjusted to yield the prediction of human responses. During eccentric rotation, the model predicts that the axis of eye rotation shifts slightly toward alignment with gravito-inertial force. The model also predicts that the time course of the perception of tilt following the acceleration phase of eccentric rotation is much slower than that during deceleration. During off vertical axis rotation (OVAR) the model predicts a small horizontal bias along with small horizontal, vertical, and torsional oscillations. Following OVAR stimulation, when stopped right- or left-side down, a small vertical component is predicted that decays with the horizontal post-rotatory response. All of the predictions are consistent with measurements of human responses.

Description: We have examined the feasibility of using massively-parallel and vector-processing supercomputers to solve large-scale optimization problems for human movement. Specifically, we compared the computational expense of determining the optimal controls for the single support phase of gait using a conventional serial machine (SGI Iris 4D25), a MIMD parallel machine (Intel iPSC/860), and a parallel-vector-processing machine (Cray Y-MP 8/864). With the human body modeled as a 14 degree-of-freedom linkage actuated by 46 musculotendinous units, computation of the optimal controls for gait could take up to 3 months of CPU time on the Iris. Both the Cray and the Intel are able to reduce this time to practical levels. The optimal solution for gait can be found with about 77 hours of CPU on the Cray and with about 88 hours of CPU on the Intel. Although the overall speeds of the Cray and the Intel were found to be similar, the unique capabilities of each machine are better suited to different portions of the computational algorithm used. The Intel was best suited to computing the derivatives of the performance criterion and the constraints whereas the Cray was best suited to parameter optimization of the controls. These results suggest that the ideal computer architecture for solving very large-scale optimal control problems is a hybrid system in which a vector-processing machine is integrated into the communication network of a MIMD parallel machine.

Description: Prolonged head-down bed rest (HDBR) provides a model for examining responses to chronic weightlessness in humans. Eight healthy volunteers underwent HDBR for 2 wk. Antecubital venous blood was sampled for plasma levels of catechols [norepinephrine (NE), epinephrine, dopamine, dihydroxyphenylalanine, dihydroxyphenylglycol, and dihydroxyphenylacetic acid] after supine rest on a control (C) day and after 4 h and 7 and 14 days of HDBR. Urine was collected after 2 h of supine rest during day C, 2 h before HDBR, and during the intervals 1-4, 4-24, 144-168 (day 7), and 312-336 h (day 14) of HDBR. All subjects had decreased plasma and blood volumes (mean 16%), atriopeptin levels (31%), and peripheral venous pressure (26%) after HDBR. NE excretion on day 14 of HDBR was decreased by 35% from that on day C, without further trends as HDBR continued, whereas plasma levels were only variably and nonsignificantly decreased. Excretion rates of dihydroxyphenylglycol and dihydroxyphenylalanine decreased slightly during HDBR; excretion rates of epinephrine, dopamine, and dihydroxyphenylacetic acid and plasma levels of catechols were unchanged. The results suggest that HDBR produces sustained inhibition of sympathoneural release, turnover, and synthesis of NE without affecting adrenomedullary secretion or renal dopamine production. Concurrent hypovolemia probably interferes with detection of sympathoinhibition by plasma levels of NE and other catechols in this setting. Sympathoinhibition, despite decreased blood volume, may help to explain orthostatic intolerance in astronauts returning from spaceflights.

Description: The purpose was to determine whether extracellular volume or osmolality was the major contributing factor for reduction of thirst in air and head-out water immersion in hypohydrated subjects. Eight males (19-25 yr) were subjected to thermoneutral immersion and thermoneutral air under two hydration conditions without further drinking: euhydration in water (Eu-H2O) and euhydration in air, and hypohydration in water (Hypo-H2O) and hypohydration in air (3.7% wt loss after exercise in heat). The increased thirst sensation with Hypo-H2O decreased (P 〈 0.05) within 10 min of immersion and continued thereafter. Mean plasma osmolality (288 +/- 1 mosmol/kgH2O) and sodium (140 +/- 1 meq/l) remained elevated, and plasma volume increased by 4.2 +/- 1.0% (P 〈 0.05) throughout Hypo-H2O. A sustained increase (P 〈 0.05) in stroke volume accompanied the prompt and sustained decrease in plasma renin activity and sustained increase (P 〈 0.05) in plasma atrial natriuretic peptide during Eu-H2O and Hypo-H2O. Plasma vasopressin decreased from 5.3 +/- 0.7 to 2.9 +/- 0.5 pg/ml (P 〈 0.05) during Hypo-H2O but was unchanged in Eu-H2O. These findings suggest a sustained stimulation of the atrial baroreceptors and reduction of a dipsogenic stimulus without major alterations of extracellular osmolality in Hypo-H2O. Thus it appears that vascular volume-induced stimuli of cardiopulmonary baroreceptors play a more important role than extracellular osmolality in reducing thirst sensations during immersion in hypohydrated subjects.

Description: Loss of skeletal weight bearing or physical unloading of bone in the growing animal inhibits bone formation and induces a bone mineral deficit. To determine whether the inhibition of bone formation induced by skeletal unloading in the growing animal is a consequence of diminished sensitivity to growth hormone (GH) we studied the effects of skeletal unloading in young hypophysectomized rats treated with GH (0, 50, 500 micrograms/100 g body weight/day). Skeletal unloading reduced serum osteocalcin, impaired uptake of 3H-proline into bone, decreased proximal tibial mass, and diminished periosteal bone formation at the tibiofibular junction. When compared with animals receiving excipient alone, GH administration increased bone mass in all animals. The responses in serum osteocalcin, uptake of 3H-proline and 45Ca into the proximal tibia, and proximal tibial mass in non-weight bearing animals were equal to those in weight bearing animals. The responses in trabecular bone volume in the proximal tibia and bone formation at the tibiofibular junction to GH, however, were reduced significantly by skeletal unloading. Bone unloading prevented completely the increase in metaphyseal trabecular bone normally induced by GH and severely dampened the stimulatory effect (158% vs. 313%, p 〈 0.002) of GH on periosteal bone formation. These results suggest that while GH can stimulate the overall accumulation of bone mineral in both weight bearing and non-weight bearing animals, skeletal unloading selectively impairs the response of trabecular bone and periosteal bone formation to the anabolic actions of GH.

Description: We tested the hypothesis that one bout of maximal exercise performed 24 h before reambulation from 16 days of 6 degrees head-down tilt (HDT) could increase integrated baroreflex sensitivity. Isolated carotid-cardiac and integrated baroreflex function was assessed in seven subjects before and after two periods of HDT separated by 11 mo. On the last day of one HDT period, subjects performed a single bout of maximal cycle ergometry (exercise). Subjects did not exercise after the other HDT period (control). Carotid-cardiac baroreflex sensitivity was evaluated using a neck collar device. Integrated baroreflex function was assessed by recording heart rate (HR) and blood pressure (MAP) during a 15-s Valsalva maneuver (VM) at a controlled expiratory pressure of 30 mmHg. The ratio of change in HR to change in MAP (delta HR/ delta MAP) during phases II and IV of the VM was used as an index of cardiac baroreflex sensitivity. Baroreflex-mediated vasoconstriction was assessed by measuring the late phase II rise in MAP. Following HDT, carotid-cardiac baroreflex sensitivity was reduced (2.8 to 2.0 ms/mmHg; P = 0.05) as was delta HR/ delta MAP during phase II (-1.5 to -0.8 beats/mmHg; P = 0.002). After exercise, isolated carotid baroreflex activity and phase II delta HR/ delta MAP returned to pre-HDT levels but remained attenuated in the control condition. Phase IV delta HR/ delta MAP was not altered by HDT or exercise. The late phase II increase of MAP was 71% greater after exercise compared with control (7 vs. 2 mmHg; P = 0.041).(ABSTRACT TRUNCATED AT 250 WORDS).

Description: Orthostatic hypotension is characterized by low upright blood pressure levels and symptoms of cerebral hypoperfusion. Whereas orthostatic hypotension is heterogeneous, correct pathophysiologic diagnosis is important because of therapeutic and prognostic considerations. Although therapy is not usually curative, it can be extraordinarily beneficial if it is individually tailored. Management of the Shy-Drager syndrome (multiple-system atrophy) remains a formidable challenge.

Description: Mechanotransduction plays a crucial role in the physiology of many tissues including bone. Mechanical loading can inhibit bone resorption and increase bone formation in vivo. In bone, the process of mechanotransduction can be divided into four distinct steps: (1) mechanocoupling, (2) biochemical coupling, (3) transmission of signal, and (4) effector cell response. In mechanocoupling, mechanical loads in vivo cause deformations in bone that stretch bone cells within and lining the bone matrix and create fluid movement within the canaliculae of bone. Dynamic loading, which is associated with extracellular fluid flow and the creation of streaming potentials within bone, is most effective for stimulating new bone formation in vivo. Bone cells in vitro are stimulated to produce second messengers when exposed to fluid flow or mechanical stretch. In biochemical coupling, the possible mechanisms for the coupling of cell-level mechanical signals into intracellular biochemical signals include force transduction through the integrin-cytoskeleton-nuclear matrix structure, stretch-activated cation channels within the cell membrane, G protein-dependent pathways, and linkage between the cytoskeleton and the phospholipase C or phospholipase A pathways. The tight interaction of each of these pathways would suggest that the entire cell is a mechanosensor and there are many different pathways available for the transduction of a mechanical signal. In the transmission of signal, osteoblasts, osteocytes, and bone lining cells may act as sensors of mechanical signals and may communicate the signal through cell processes connected by gap junctions. These cells also produce paracrine factors that may signal osteoprogenitors to differentiate into osteoblasts and attach to the bone surface. Insulin-like growth factors and prostaglandins are possible candidates for intermediaries in signal transduction. In the effector cell response, the effects of mechanical loading are dependent upon the magnitude, duration, and rate of the applied load. Longer duration, lower amplitude loading has the same effect on bone formation as loads with short duration and high amplitude. Loading must be cyclic to stimulate new bone formation. Aging greatly reduces the osteogenic effects of mechanical loading in vivo. Also, some hormones may interact with local mechanical signals to change the sensitivity of the sensor or effector cells to mechanical load.

Description: The Division of Emergency Medicine at the University of Florida coordinates a unique program with the NASA John F. Kennedy Space Center (KSC) to provide emergency medical support (EMS) for the United States Space Transportation System. This report outlines the organization of the KSC EMS system, training received by physicians providing medical support, logistic and operational aspects of the mission, and experiences of team members. The participation of emergency physicians in support of manned space flight represents another way that emergency physicians provide leadership in prehospital care and disaster management.

Description: No abstract available

Description: We examine 10 coronal mass ejections from the in-ecliptic portion of the Ulysses mission. Five of these CMEs are magnetic clouds. In each case we observe an inverse relationship between electron temperature and density. For protons this relationship is less clear. Earlier work has shown a similar inverse relationship for electrons inside magnetic clouds and interpreted it to mean that the polytropic index governing the expansion of electrons is less than unity. This requires electrons to be heated as the CME expands. We offer an alternative view that the inverse relationship between electron temperature and density is caused by more rapid cooling of the denser plasma through collisions. More rapid cooling of denser plasma has been shown for 1 AU measurements in the solar wind. As evidence for this hypothesis we show that the denser plasma inside the CMEs tends to be more isotropic indicating a different history of collisions for the dense plasma. Thus, although the electron temperature inside CMEs consistently shows an inverse correlation with the density, this is not an indication of the polytropic index of the plasma but instead supports the idea of collisional modification of the electrons during their transit from the sun.

Description: Mean values of a number of parameters of the most powerful coronal mass ejections (CMEs) and interplanetary shocks generated by these ejections are estimated using an analysis of data obtained by the cosmic coronagraphs and spacecrafts, and geomagnetic storm measurements. It was payed attention that the shock mass and mechanical energy, averaging 5 x 10(exp 16) grm and 2 x 10(exp 32) erg respectively, are nearly 10 times larger than corresponding parameters of the ejections. So, the CME energy deficit problem seems to exist really. To solve this problem one can make an assumption that the process of the mass and energy growth of CMEs during their propagation out of the Sun observed in the solar corona is continued in supercorona too up to distances of 10-30 solar radii. This assumption is confirmed by the data analysis of five events observed using zodiacal light photometers of the HELIOS- I and HELIOS-2 spacecrafts. The mass growth rate is estimated to be equal to (1-7) x 10(exp 11) grm/sec. It is concluded that the CME contribution to mass and energy flows in the solar winds probably, is larger enough than the value of 3-5% adopted usually.

Description: Solar wind proton temperatures lower than expected for 'normal' solar wind expansion are a common signature of 'ejecta' (i.e. interplanetary coronal mass ejections). We have surveyed the OMNI solar wind data base for 1965-1991, and Helios data for 1974-1980, to identify regions of abnormally low temperatures. Their occurrence rate is clearly dependent on solar activity levels, in particular when the minority of events associated with encounters with the heliospheric plasma sheet are excluded. The analysis of the OMNI data may provide an indication of the rate of ejecta at the Earth, and hence of the CME rate, extending back to before spacecraft coronagraph observations became available in the early 1970's. We discuss the association of these solar wind structures with cosmic ray depressions bidirectional particle flows, and other ejecta signatures. Our impression is that no one ejecta signature provides a truly comprehensive indication of the presence of ejecta, but that abnormally low temperature depressions encompass most of the regions identified by these other individual signatures.

Description: We have been carrying out the interplanetary scintillation observations at a frequency of 327 MHz. The IPS measurements at this frequency can probe the distance range of 0.1-1 AU. We will report on source regions of the low-speed winds which were observed within 0.3 AU by the IPS method. The source regions of low-speed winds have been studied. In 1991, two spacecraft of Sakigake and IMP observed two low-speed streams in one solar rotation, which originated from a magnetic neutral line on the source surface. However speeds are slightly different from each other: one is 300 km/s while the other one is 400 km/s. Similar speed difference was also observed by the IPS method. We examined differences of these source regions in the soft X-ray images observed by the Yohkoh satellite. At the source region of the lower speed wind, sun spots were found under the neutral line, while nothing except the neutral line was found for the higher speed wind. We made a synoptic chart of the solar wind speeds which were observed within 0.3 AU. In this chart, compact regions of very low speed can be found clearly, and the amplitude of a low-speed belt is smaller than that of a magnetic neutral line. Distribution of the low-speed belt is rather suited above active regions than on a neutral line calculated by the potential field model.

Description: The radial distance dependence of solar wind speeds, which were measured by interplanetary scintillation method, has been studied especially for a high-speed solar wind, and large increase of the IPS speeds (300 km/s) was observed at the distance range of 0.1 - 0.3 AU. When the streams are mapped back onto the source surface, they distribute in polar coronal holes or their boundaries. Since the IPS measurement can be biased by several effects such as of line-of-sight integration, strong scattering and random velocities, we examined these biasing effects and have found difficulty to explain the large IPS speed increase with the biasing effects.

Description: Two-antenna scintillation (IPS) observations can provide accurate measurements of the velocity with which electron density fluctuations drift past the line of sight. We will present recent IPS measurements made with the EISCAT and VLBA arrays. It is common, particularly during declining activity. for the line of sight to pass through plasma with a wide range of speed. Therefore it is important to account for the line of sight integration. It is clear from ULYSSES measurements that the speed is bimodal in nature, i.e., either 'fast' or 'slow.' Thus it is not necessary to model a continuous velocity distribution - one need only locate the 'fast-slow' interface. In addition one must consider the possibility that the density fluctuations are moving with respect to the flow of particles. Alfven waves propagating through field-aligned density fluctuations can mimic a sound wave in this respect, so the apparent IPS velocity can be the flow speed plus the Alfven speed. In modeling the IPS it is important that the scattering be 'weak,' because the weak scattering model requires only 1 spatial parameter instead of 3. Furthermore the effect of multiple velocities in much more distinct in weak scattering. EISCAT can only operate near 933 MHz, which limits the observations to outside of 17R(solar mass). The VLBA is the only facility with the combination of high frequency operation and long baselines required to observe inside of 15R(solar mass). A simple bimodal model has been successfully used to interpret our IPS observations near the sun. Farther out interaction regions have built up significantly and a two speed model is no longer valid. An apparent deceleration in the fast polar wind is sometimes evident when compared to the ULYSSES observation. The density variance delta N(exp 2)e in the fast wind appears to decrease from equator to pole.

Description: Recent observations of coronal holes made with the soft X-ray telescope aboard Yohkoh have indicated a temperature of 1.8 approximately 2.1 x 10(exp 6) K and an emission measure of 10(exp 25.7 approximately 26.2) cm (exp -5). This is almost the same as in quiet regions of the Sun. Numerical simulations of the temperature density and velocity structure in a coronal hole. using a parameterized heating distribution have been used for a comparison with the Yohkoh observations. Models are obtained which fit the observed temperature and emission measure. with heating fluxes which are consistent with other measurements. However, the final velocity of the solar wind is very slow which indicates the necessity of another acceleration mechanism such as alfven waves.

Description: In the solar corona shock waves generated by flares and/or coronal mass ejections can be observed by radio astronomical methods in terms of solar type 2 radio bursts. In dynamic radio spectra they appear as emission stripes slowly drifting from high to low frequencies. A sample of 25 solar type 2 radio bursts observed in the range of 40 - 170 MHz with a time resolution of 0.1 s by the new radiospectrograph of the Astrophvsikalisches Institut Potsdam in Tremsdorf is statistically investigated concerning their spectral features, i.e, drift rate, instantaneous bandwidth, and fundamental harmonic ratio. In-situ plasma wave measurements at interplanetary shocks provide the assumption that type 2 radio radiation is emitted in the vicinity of the transition region of shock waves. Thus, the instantaneous bandwidth of a solar type 2 radio burst would reflect the density jump across the associated shock wave. Comparing the inspection of the Rankine-Hugoniot relations of shock waves under coronal circumstances with those obtained from the observational study, solar type 2 radio bursts should be regarded to be generated by weak supercritical, quasi-parallel, fast magnetosonic shock waves in the corona.

Description: A number of theoretical works have suggested that MHD plasma fluctuations in solar winds should play an important role particularly in the acceleration of high speed winds inside or near 0.1 AU from the sun. Since velocity fluctuations in solar winds are expected to be caused by the MHD plasma fluctuations, measurements of the velocity fluctuations give clues to reveal the acceleration process of solar winds. We made interplanetary scintillation (IPS) observations at the region out of 0.1 AU to investigate dependence of velocity fluctuations on flow speeds. For evaluating the velocity fluctuation of a flow, we selected the IPS data-set acquired at 2 separate antennas which located in the projected flow direction onto the baseline plane, and tried to compare skewness of the observed cross correlation function(CCF) with skewness of modeled CCFs in which velocity fluctuations were parametrized. The integration effect of IPS along a ray path was also taken into account in the estimation of modeled CCFs. Although this analysis method is significant to derive only parallel fluctuation components to the flow directions, preliminary analyses show following results: (1) High speed winds (Vsw greater than or equal to 500 km/s out of 0.3 AU) indicate enhancement of velocity fluctuations near 0.1 AU; and (2) Low speed winds (Vsw less than or equal to 400 Km/s out of 0.3 AU) indicate small velocity fluctuations at any distances.

Description: Interplanetary scintillation observations of the solar wind acceleration region (solar elongation: R approximately 4-30 R(solar mass)) have been performed at the Effelsberg and Pushino telescopes using natural radio sources. The water maser source IRC-20431 was observed at the wavelength lambda = 1.35 cm in a series of nine scintillation experiments performed during the December solar occultations from 1981 to 1994. Dramatic changes in the radial dependence of the scintillation index m(R) were recorded over the course of the 11-year solar cycle. Decidedly reduced scattering, attributed to a pronounced heliolatitude effect, was observed at the closest solar approach distances in the years around solar activity minimum. The anisotropy of the solar scattering region slowly evolves to a spherically symmetric pattern in the years of high solar activity as more intensive scattering returns to the polar latitudes.

Description: We have studied the evolution of the velocity distribution function of a test population of electrons in the solar corona and inner solar wind region, using a recently developed kinetic model. The model solves the time dependent, linear transport equation, with a Fokker-Planck collision operator to describe Coulomb collisions between the 'test population' and a thermal background of charged particles, using a finite differencing scheme. The model provides information on how non-Maxwellian features develop in the distribution function in the transition region from collision dominated to collisionless flow. By taking moments of the distribution the evolution of higher order moments, such as the heat flow, can be studied.

Description: The outflow of coronal plasma into interplanetary space is a consequence of the coronal heating process. Therefore the formation of the corona and the acceleration of the solar wind should be treated as a single problem. Traditionally the mass or particle flux emanating from the extended corona has been thought of as being determined by the coronal temperature or scale height and the coronal (base) density. This argument follows from considerations of the momentum balance of the corona-wind system from which one obtains models of a close to hydrostatic corona out to the critical point where the flow becomes supersonic. With this approach to the acceleration of the wind is has been difficult to reconcile the relatively small variation observed in the proton flux at 1 AU with the predicted exponential dependence of the proton flux on the coronal temperature. In this talk we would like to emphasize another approach in which coronal energetics play the primary role. The deposition of energy into the corona through some 'mechanical' energy flux is balanced by the various energy sinks available to the corona and the sum of these processes determine the coronal structure, i.e. its temperature and density. The corona loses energy through heat conduction into the transition region, through radiative losses, and through the gravitational potential energy and kinetic energy put into the solar wind itself. We will show from a series of models of the chromosphere transition region-corona-solar wind system that most of the energy deposited in a magnetically open region will go into the solar wind, with roughly half going into kinetic energy and half into lifting the plasma out of the solar gravity field. The coronal base density will adjust itself in such a way that the heat conductive flux flowing into the transition region is radiated away in the upper chromosphere. The coronal temperature is set by the requirements that most of the deposited energy goes into accelerating the solar wind; the coronal scale height will adjust itself so that the solar wind energy losses conform to the amplitude of the input energy. These processes are modified by the 'mode' of energy deposition, and we will show the effects on coronal structure of changing the parameters describing coronal heating as well as the effects of including a helium fluid in the models. However, the location, scale height and/or form of the energy deposition (i.e. heating or direct acceleration) are not too important for the solar wind, the coronal density and temperature structure will vary with the 'mode' of energy deposition, but the solar wind mass flux depends mainly on the amplitude of the energy flux.

Description: Coronal heating is at the origin of the X-ray emission and mass loss from the sun and many other stars. While different scenarios have been proposed to explain the heating of magnetically confined and open regions of the corona, they must all rely on the transfer, storage and dissipation of the abundant energy present in photospheric motions. Here we focus on theories which rely on magnetic fields and electric currents both for the energy transfer and storage in the corona. The dissipation of this energy, whether in the form of reconnection in current sheets (nanoflare?) or the dissipation of MHD waves, depends crucially on the development of extremely small scales in the coronal magnetic field, where kinetic effects are likely to be fundamental. The question of whether coronal heating and flares may be viewed respectively as the macroscopic, low-energy average and the high-energy, temporally intermittent aspect of the same underlying driven, dissipative, turbulent system is also addressed, with emphasis placed on the main observational and theoretical stumbling blocks in the way of a confinement or disproof of such a conjecture.

Description: In weakly dissipative media governed by the magnetohydrodynamics (MHD) equations, any efficient mechanism of energy dissipation requires the formation of small scales. The possibility to produce small scales has been studied by Malara et al. in the case of MHD disturbances propagating in an incompressible and inhomogeneous medium, for a strictly 2D geometry. We extend the work of Malara et al. to include both compressibility and the third component for vector quantities. Using numerical simulations we show that, when an Alfven wave propagates in a compressible nonuniform medium, the two dynamical effects responsible for the small scales formation in the incompressible case are still at work: energy pinching and phase-mixing. Moreover, the interaction between the initial Alfven wave and the inhomogeneity gives rise to the formation of compressible perturbations (fast and slow waves or a static entropy wave). Some of these compressive fluctuations are subject to the steepening of the wave front and become shock waves, which are extremely efficient in dissipating their energy, their dissipation being independent of the Reynolds number. A rough estimate of the typical times which the various dynamical processes take to produce small scales and then to dissipate the energy show that these times are consistent with those required to dissipate inside the solar corona the energy of Alfven waves of photospheric origin.

Description: The National Solar Observatory synoptic program provides an extensive and unique data base of high-resolution full-disk observations of the line-of-sight photospheric magnetic fields and of the He I lambda 10830 equivalent width. These data have been taken nearly daily for more than 21 years since 1974 and provide the opportunity to investigate the behavior of the magnetic fields in the photosphere and those inferred for the corona spanning on the time scales of a day to that of a solar cycle. The intensity of structures observed in He I lambda 10830 are strongly modulated by overlying coronal radiation; areas with low coronal emission are generally brighter in He I lambda 10830, while areas with high coronal emission are darker. For this reason, He I lambda 10830 was selected in the mid-1970's as way to identify and monitor coronal holes, magnetic fields with an open configuration, and the sources of high-speed solar wind streams. The He I lambda 10830 spectroheliograms also show a wide variety of other structures from small-scale, short-lived dark points (less than 30 arc-sec, hours) to the large-scale, long-lived two 'ribbon' flare events that follow the filament eruptions (1000 arc-sec, days). Such structures provide clues about the connections and changes in the large-scale coronal magnetic fields that are rooted in concentrations of magnetic network and active regions in the photosphere. In this paper, what observations of the photospheric magnetic field and He I lambda 10830 can tell us about the short- and long-term evolution of the coronal magnetic fields will be discussed, focussing on the quiet Sun and coronal holes. These data and what we infer from them will be compared with direct observations of the coronal structure from the Yohkoh Soft X-ray Telescope.

Description: The high speed solar wind, which is associated with coronal holes and unipolar interplanetary magnetic field, has now been observed in situ beyond 0.3 a.u. and at latitudes up to 80 degrees. Its important characteristics are that it is remarkably steady in terms of flow properties and composition and that the ions, especially minor species, are favored in terms of heating and acceleration. We have proposed that the high speed wind, with its associated coronal holes, forms the basic mode of solar wind flow. In contrast, the low speed wind is inherently non-stationary, filamentary and not in equilibrium with conditions at the coronal base. It is presumably the result of continual reconfigurations of the force-free magnetic field in the low-latitude closed corona which allow trapped plasma to drain away along transiently open flux tubes. Observations of high speed solar wind close to its source are hampered by the essential heterogeneity of the corona, even at sunspot minimum. In particular it is difficult to determine more than limits to the density, temperature and wave amplitude near the coronal base as a result of contamination from fore- and back-ground plasma. We interpret the observations as indicating that the high speed solar wind originates in the chromospheric network, covering only about 1% of the surface of the sun, where the magnetic field is complex and not unipolar. As a result of small-scale reconnection events in this 'furnace', Alfven waves are generated with a flat spectrum covering the approximate range 10 kHz to 10 Hz. The plasma is likely to be produced as a result of downwards thermal conduction and possibly photoionization at the top of the low density chromospheric interface to the furnace, thus controlling the mass flux in the wind. The immediate source of free (magnetic) energy is in the form of granule-sized loops which are continually carried into the network from the sides. The resulting wave spectrum is such that energy can be efficiently transferred to the ions within a few solar radii of the base of the corona, favoring heavy species and creating stable, fast solar wind.

Description: Observations of solar Lyman alpha have been interpreted as indicating that the polar mass flux density is lower than the equatorial average. This led Lallement et al (1986) to make a parametric study of solar wind acceleration, along the lines of earlier the Munro-Jackson study (1977), in which they concluded that uncertainties in the polar mass flux were large enough to be consistent with two extreme opposites: (1) a substantial energy supply beyond classical thermal conduction is required; or (2) classical thermal conduction is adequate to drive the flow. This ambiguity has been clarified by Ulysses observations of the polar outflow (Phillips et al, 1994). The polar mass flux density lies in the middle of the range studies by Lallement et al (1986), which suggests that extended heating is going on out to at least approximately 5 AU. Independent, purely energetic arguments can be made to estimate the required coronal source (electron) temperature that would be required to account for the observed energy flux density. An electron temperature of at least 2 x 10(exp 6) K would be required for the classical conduction flux density to be comparable to the total energy flux density; such a high temperature is thought to be unlikely in a coronal hole. These arguments strongly suggest that some extended heating or momentum transfer mechanism is required to drive the solar wind from the polar coronal hole. A number of mechanisms are discussed.

Description: Different types of nonlinear shock wave interactions in some regions of the solar wind flow are considered. It is shown, that the solar flare or nonflare CME fast shock wave may disappear as the result of the collision with the rotational discontinuity. By the way the appearance of the slow shock waves as the consequence of the collision with other directional discontinuity namely tangential is indicated. Thus the nonlinear oblique and normal MHD shock waves interactions with different solar wind discontinuities (tangential, rotational, contact, shock and plasmoidal) both in the free flow and close to the gradient regions like the terrestrial magnetopause and the heliopause are described. The change of the plasma pressure across the solar wind fast shock waves is also evaluated. The sketch of the classification of the MHD discontinuities interactions, connected with the solar wind evolution is given.

Description: A fundamental problem in Solar-Terrestrial Physics is the origin of the solar transient plasma output, which includes the coronal mass ejection and its interplanetary manifestation, e.g. the magnetic cloud. The traditional blast wave model resulted from solar thermal pressure impulse has faced with challenge during recent years. In the MHD numerical simulation study of CME, the authors find that the basic feature of the asymmetrical event on 18 August 1980 can be reproduced neither by a thermal pressure nor by a speed increment. Also, the thermal pressure model fails in simulating the interplanetary structure with low thermal pressure and strong magnetic field strength, representative of a typical magnetic cloud. Instead, the numerical simulation results are in favor of the magnetic field expansion as the likely mechanism for both the asymmetrical CME event and magnetic cloud.

Description: Coronal holes are the sources of the solar wind and, according to recent YOKOH observations, may undergo rapid changes which are associated with manifestations of explosive solar activity. Rapid changes in a hole's structure will produce rapid changes in the characteristics of the wind emerging from it and, in the particular c se of a sudden increase in wind velocity, this may lead to the formation of an interplanetary shock. We discuss the characteristics of shocks formed in such a way and compare them with interplanetary observations.

Description: Ulysses observations have revealed a new class of forward-reverse shock pairs in the solar wind that appears to be restricted to high heliographic latitudes. Shock pairs in this new class of events are produced by over-expansion (i.e., expansion driven by a high internal pressure) of coronal mass ejections, CMEs, that have speeds comparable to that of the surrounding solar wind plasma. Here we compare low- and high-latitude observations of an event observed both near Earth by IMP 8 and at high latitudes by Ulysses. At the time of these observations Ulysses was at 3.53 AU and was situated 47.2 deg south and 11.4 deg west of Earth (in the sense of planetary motion about the Sun). A fast CME that departed from the Sun on February 20, 1994 produced both a major (forward) shock wave disturbance in the ecliptic plane at 1 AU (and a large geomagnetic storm) and a forward reverse shock pair associated with over-expansion of the CME at high heliographic latitudes. The combined measurements provide a graphic illustration of how the same fast CME can produce totally different types of disturbances at low and high latitudes. Differences in the disturbances generated by the CME at high and low latitudes are due primarily to the different speeds initially prevailing in the ambient solar wind ahead of it. These observations are consistent with the results of simple numerical simulations of the event.

Description: Masses have now been determined for many of the CMEs observed in the inner heliosphere by the HELIOS 1 and 2 zodiacal light photometers. The speed of the brightest material of each CME has also been measured so that, for events having both mass and speed determinations, the kinetic energies of the CMEs are estimated. We compare the masses and kinetic energies of the individual CMEs measured in the inner heliosphere by HELIOS and near the Sun from observations by the SOLWIND (1979-1983) and SMM coronagraphs (1980). Where feasible we also compare the speeds of the same CMEs. We find that the HELIOS masses and energies tend to be somewhat larger by factors of 2-5 than those derived from the coronagraph data. We also compare the distribution of the masses and energies of the HELIOS and coronagraph CMEs over the solar cycle. These results provide an important baseline for observations of CMEs from coronagraphs, from the ISEE-3/ICE, WIND and Ulysses spacecraft and in the future from SOHO.

Description: A large number of magnetic holes have been found in the Ulysses data during its cruise in the ecliptic. They are interpreted as convecting structures, probably caused by the mirror instability which exists in high beta plasmas with anisotropic temperatures. The characteristics of the holes reflect the solar wind condition of the region in which the holes are formed, and the point of observation may be far removed from where the instability occurs. A preliminary survey appears to indicate that the number of holes has no significant radial dependence. However, the number of holes does appear to increase with increasing heliographic latitude. Yet the large scale solar wind structures with their compression regions disappeared at approximately 57 deg south latitude. Thus any causal relationship between the holes and large scale solar wind structures is questionable. The temperature anisotropy and high beta required by the mirror instability must be generated by other mechanisms. In order to tie the magnetic holes and the mirror instability to their cause, the evolution of their characteristics with heliocentric distance and latitude needs to be investigated. With the progression of Ulysses around the sun a survey will be conducted to ascertain the characteristics of the magnetic holes as a function of heliographic latitude and heliocentric distance. A comparison of the results with the solar wind conditions may lead to the identification of the magnetic hole generating mechanism(s).

Description: The solar corona was observed with an externally occulted White Light Coronagraph (WLC) carried on the SPARTAN 201-1 spacecraft on 11-12 Apr. 1993. With observations from WLC and the ground based Mauna Loa White Light Coronagraph, a large number of polar plumes both in the north and south polar holes were traced from 1.16 to 5.5 Rs. Flow properties of the solar wind in coronal holes have been determined (Habbal et al., 1995) by using a two fluid model constrained by density profiles and scale height temperatures from the white light observations, and interplanetary measurements of the flow speed and proton mass flux from Ulysses' south polar passage. Provisions for acceleration by Alfven waves, as well as electron and proton heating, are included in the momentum and the energy equations respectively. The model computations fit remarkably well the empirical constraints of the two different density structures (plumes and coronal holes) for a range of input parameters. In this study we investigate the physical nature of the heating function used in the two-fluid model. Alfven waves have been suggested as the possible source of heating that accelerates the solar wind (Ofman and Davila, 1995). We utilize the density contrast observed in WLC data in the plume and ambient coronal hole region to estimate the Alfven wave frequencies responsible for heating these structures. The source heating function utilized in the two fluid model of the solar wind acceleration will be compared with the resonant Alfven wave heating function.

Description: We have been comparing measurements of solar wind speed at the Ulysses spacecraft with coronal flux-tube expansion rates, derived from photospheric field measurements using a current-free coronal model. The large-scale patterns of derived speed have continued to reproduce the observed patterns from launch through south polar passage to the present 40S latitude of the spacecraft. The fastest non-transient wind speeds of approx. 860 km/s were encountered at midlatitudes en route to the south pole, rather than during polar passage when the peak speeds were approx. 820 km/s. Although this result is in qualitative agreement with the idea that the wind speed is controlled by the coronal flux-tube expansion rate, the 40 km/s difference is significantly smaller than the 100-150 km/s difference based on our in-ecliptic calibration. This paper will summarize our attempts to resolve this discrepancy and will show the observational status of our coronal/interplanetary comparison at the time of the meeting.

Description: The Yohkoh/SXT images provide full-disk coverage of the solar corona, usually extending before and after one of the large-scale eruptive events that occur in the polar crown These produce large arcades of X-ray loops, often with a cusp-shaped coronal extension, and are known to be associated with coronal mass ejections. The Yohkoh prototype of such events occurred 12 Nov. 1991. This allows us to determine heights from the apparent rotation rates of these structures. In comparison v with magnetic-field extrapolations from Wilcox Solar Observatory. use use this tool to infer the three dimensional structure of the corona in particular cases: 24 Jan. 1992, 24 Feb. 1993, 14 Apr. 1994, and 13 Nov. 1994. The last event is a long-duration flare event.

Description: The single-station measurements of interplanetary scintillation (IPS) at 2 and 8 GHz have been made at the Kashima Space Research Center of the Communications Research Laboratory in the period from 1990 to 1994. These IPS data are used to study the radial distribution of solar wind velocity and density fluctuations near the sun (i.e. 10-70 Rs), and the long-term variation in these properties. The IPS co-spectrum technique is applied here to estimate the solar wind velocity. Derived velocities show that the solar wind gains a speed significantly in the radial range from 10 to 30 Rs (solar radii). which is much farther than the source surface of the thermally driven solar wind model. From the scintillation index analysis. it is found that the radial fall of density fluctuations is well described by the power-law function. A series of IPS observations reveals that a pronounced change in velocity and turbulence level for this radial range occurs at the polar region of the sun during 1990-1994. That is, the high speed wind and the reduced turbulence region develop there as the solar activity declines. On the other hand, little long-term variation is observed for the solar wind acceleration region at a low latitude. From the comparison with He 1O83 nm observations. it is demonstrated that the change of the solar wind structure is closely linked with the evolution of the coronal hole on the solar surface.

Description: Results of the close-to-Sun plasmas sounding at the transonic region of the solar wind, where the sub-to supersonic flow transition proceeds (at 10 to 40 solar radii from the Sun), are presented. Natural sources of two types were used, water vapour maser sources at 1.35 cm and guasars at 2.9 m wavelength. scattering observations cover the period of 1986 to 1993, Russian Academy of Sciences telescopes RT-22 and DCR-1000 were used, IPS index and scattering angle being the immediate results of observations. Extensive studies of the scintillation index and scattering angle radial profiles reveal a remarkable structural detail, 'transonic region forrunner'-narrow region of diminished scattering close to the internal border of the extended transonic region with its characteristic enhanced scattering. Comparisons of the scattering and plasma velocity profiles let it possible to determine the critical point positions by the comparatively simple scattering observations. This new possibility widely improves the process of the basic data accumulation in the fundamental problem of the solar wind acceleration mechanism.

Description: Helioseismology began in earnest in the mid 1970's. In the two decades which have elapsed since that time this branch of solar physics has become a mature field of research. Helioseismology has demonstrated that the solar convection zone is about twice as deep as was generally thought to be the case before 1977. Helioseismology has also provided measurements of the solar internal angular velocity over much of the sun's interior. Helioseismology has also ruled out models which would solve the solar neutrino problem by a lowering of the temperature of the core. Recently, some of the seismic properties of the sun have been demonstrated to vary with changing levels of solar activity. Also, helioseismology has recently provided evidence for helical flow patterns in the shallow, sub-photosphere layers. The techniques of helioseismology are also expanding to include seismic probes of solar active regions. Some work is also being conducted into the possible contributions of the solar acoustic models to the heating of the solar atmosphere. In this talk I will highlight a few of the above results and concentrate on current areas of research in the field.

Description: The traditionally measured electric fields in the solar wind plasma (about 1-10 mV/m) are not the natural, primordial ones but are the result of plasma-vehicle interaction. The theory of this interaction is not complete now and current interpretation of the measurements can fail. The state of fully ionized plasma depends on the entropy of the creating source and on the process in which plasma is involved. The increasing twofold of a moving volume in the solar wind (with energy transfer across its surface which is comparable with its whole internal energy) is a more rapid process than the relaxation for the pressure. The presumptive source of the solar wind creation - the induction electric field of the solar origin - has very low entropy. The state of plasma must be very far from the state of thermodynamic equilibrium. The internal energy of plasma can be contained mainly in plasma waves, resonant plasma oscillations, and electric currents. The primordial microscopic oscillating electric fields could be about 1 V/m. It can be checked by special measurements, not ruining the natural plasma state. The tool should be a dielectrical microelectroscope outside the distortion zone of the spacecraft, having been observed from the latter.

Description: Using the empirical constraints provided by observations in the inner corona and in interplanetary space. we derive the flow properties of the solar wind using a two fluid model. Density and scale height temperatures are derived from White Light coronagraph observations on SPARTAN 201-1 and at Mauna Loa, from 1.16 to 5.5 R, in the two polar coronal holes on 11-12 Apr. 1993. Interplanetary measurements of the flow speed and proton mass flux are taken from the Ulysses south polar passage. By comparing the results of the model computations that fit the empirical constraints in the two coronal hole regions, we show how the effects of the line of sight influence the empirical inferences and subsequently the corresponding numerical results.

Description: Weak (discontinuous) solutions of the 3-D MHD equations look like a promising tool to model the transonic solar wind with structural elements: current sheets, coronal plumes etc. Using the observational information about various coronal emissions one can include these structural elements into the 3-D MHD solar wind model by embedding the discontinuities of given type. Such 3-D MHD structured solar wind is calculated self-consistently: variants are examined via numerical experiments. In particular, the behavior of coronal plumes in the transonic solar wind flow, is modeled. The input information for numerical modeling (for example, the magnetic field map at the very base of the solar corona) can be adjusted so that fast stream arises over the center of the coronal hole, over the coronal hole boundaries and, even, over the region with closed magnetic topology. 3-D MHD equations have the analytical solution which can serve as a model of supersonic trans-alfvenic solar wind in the (5-20) solar radii heliocentric distance interval. The transverse, nonradial total (gas + magnetic field) pressure balance in the flow is the corner-stone of this solution. The solution describes the filamentation (ray-like structure of the solar corona) and streaming (formation of high-speed streams with velocities up to 800 km/sec) as a consequence of the magnetic field spatial inhomogeneous structure and trans-alfvenic character of the flow. The magnetic field works in the model as a 'controller' for the solar wind streaming and filamentation.

Description: The solar wind is not an isotropic medium; two symmetry axis are provided, first the radial direction (because the mean wind is radial) and second the spiral direction of the mean magnetic field, which depends on heliocentric distance. Observations show very different anisotropy directions, depending on the frequency waveband; while the large-scale velocity fluctuations are essentially radial, the smaller scale magnetic field fluctuations are mostly perpendicular to the mean field direction, which is not the expected linear (WkB) result. We attempt to explain how these properties are related, with the help of numerical simulations.

Description: One of the striking results of the Sun's south polar pass by Ulysses was the discovery of large amplitude, long period Alfvenic fluctuations that were continuously present in the solar wind flow from the polar coronal hole. The fluctuations dominate the variances and power spectra at periods greater than or equal to 1 hour and are evident as correlated fluctuations in the magnetic field and solar wind velocity components. Various properties of the fluctuations in the magnetic field, in the velocity, and in the electric field have been established. The waves appear to have important implications for galactic cosmic rays and for the solar wind, topics which have continued to be investigated. Their origin is also under study, specifically whether or not they represent motions of the ends of the field lines at the Sun. The resolution of these issues has benefited from the more recent observations as the spacecraft traveled northward toward the ecliptic and passed into the northern solar hemisphere. All these observations will be presented and their implications will be discussed.

Description: The electron temperature is a fundamental physical parameter of the coronal plasma. Currently, there are no direct measurements of this quantity in the extended corona. Observations with the Ultraviolet Coronagraph Spectrometer (UVCS) aboard the upcoming Solar and Heliospheric Observatory (SOHO) mission can provide the most direct determination of the electron kinetic temperature (or, more precisely, the electron velocity distribution along the line of sight). This measurement is based on the observation of the Thomson-scattered Lyman alpha (Ly-alpha) profile. This observation is made particularly challenging by the fact that the integrated intensity of the electron-scattered Ly-alpha line is about 10(exp 3) times fainter than that of the resonantly-scattered Ly-alpha component. In addition, the former is distributed across 50 A (FWHM), unlike the latter that is concentrated in 1 A. These facts impose stringent requirements on the stray-light rejection properties of the coronagraph/spectrometer, and in particular on the requirements for the grating. We make use of laboratory measurements of the UVCS Ly-alpha grating stray-light, and of simulated electron-scattered Ly-alpha profiles to estimate the expected confidence levels of electron temperature determination. Models of different structures typical of the corona (e.g., streamers, coronal holes) are used for this parameter study.

Description: The magnetic field plays a major role in the physics of the solar corona. However, there are no direct measurements of this physical parameter. We describe a method that can provide the most direct determination of the vector magnetic field in the extended corona (i.e., at heliocentric heights between 1.2 R(solar radius) and 2.0 R(solar radius)). The method is based on polarimetric observations of UV lines of the Lyman series, that is, Lyman alpha (Ly-alpha), lambda 1216 A, Lyman beta (Ly-beta), lambda 1025 A, and Lyman gamma (Ly-gamma), lambda 972 A. These lines have a collisional and a resonantly scattered component. Linear polarization is induced in the resonant component by the anisotropy in the chromospheric radiation field that illuminates the corona. Magnetic fields can be suitably determined through the effects that they induce on this resonance polarization (Hanle effect). The Hanle effect of the Ly-alpha is sensitive to field strengths in the 10 - 100 gauss range. The resonance polarization of Ly-beta and Ly-gamma is sensitive, through the Hanle effect, to fields with strengths between 3 - 30 gauss, and 0.3 - 6 gauss, respectively. We describe a new method for separating the resonant from the collisional component of the Ly-beta and Ly-gamma; the method is based on the approximation, valid within 10%, that the collisional component of the Ly-alpha is negligible, in typical coronal conditions. From the intensity and the polarization of the resonant components of these Lyman lines, the strength and direction of coronal fields can be determined. We model the sensitivity of Hanle-effect diagnostics for different coronal structures (e.g., coronal holes and loops).

Description: MHD equations are considered for the solar atmosphere. 15 different simplest MHD regimes are indicated for the momentum transport equation depending on the mutual binary interplay between 6 possible and locally dominant terms: non-stationarity and inhomogeneity of the flow, gas pressure, magnetic tensions, viscous and gravity forces. These regimes are delimited by five physically independent dimensionless parameters, for example, Strouhal, sonic Mach, alfvenic Mach, Reynolds and Froude numbers or their combinations. Another partially overlapping classification of the simplest regimes may be introduced based on the energy conservation equation. There are also 15 independent binary combinations between nonstationary and inhomogeneous convective terms, dissipative energy sinks and sources (viscous, heat-conductive, Joule and radiative ones) in the energy equation. More complicated regimes are considered with multiple dominated terms. All these MHD regimes play their important role somewhere in the solar atmosphere complicated by the tensor transport coefficients in the magnetically dominated regions of the upper atmosphere. Nearly sonic and transsonic nonstationary convective motions with ascending and descending flows are observed in the solar chromosphere. the transition region and the lower pans of the solar corona together with related horizontal velocity components. This convection represents a kind of the 'cocoonery' manufacturing nonstationary vortices generated here and partially connected to the photosphere and to the solar wind. The solar wind originates from this powerful transsonic muddle in the solar atmosphere as a tiny fraction of the streamlines which are temporarily getting detached from the 'cocoons; and going to the infinity. The topologically complicated instantaneous 'runaway surface' around the Sun, i.e., the surface which separates outgoing to the infinity streams from other finite flows in the solar atmosphere was not described in the literature and needs additional investigation. We conclude that a simple one-connected smooth and quasistationary 'critical surface' which is often supposed to be placed somewhere in the solar corona (say, at 4 solar radii) in reality does not exist. Observational and theoretical arguments favor instead of this a highly structured, disordered, patched and time-dependent sonic transition surface in the solar atmosphere permanently fluctuating at positional dependent heights starting sometimes from photospheric (and maybe subphotospheric) levels and more frequently from the chromosphenc network up to several solar radii in the solar corona.

Description: Coronal hole regions are well known sources of high-speed solar wind, however to account for the observed properties of the solar wind a source of momentum and heat must be included. Alfven waves were suggested as the possible source of heating that accelerates the solar wind. We investigate the propagation of the Alfven waves in coronal holes via numerical solution of the linearized 2-D resistive MHD equations in slab geometry. The Alfven waves are driven at the lower boundary of the coronal hole and propagate into the corona. The waves are reflected at the coronal hole boundary and part of the wave energy leaks out of the coronal hole. We compare the calculated wavelengths and the attenuation rate of the fast mode Alfven waves in the leaky waveguide formed by the coronal hole with the analytical ideal MHD solutions. The formation of resonance heating layers is found to occur when shear Alfven waves propagate in an inhomogeneous coronal hole. The heating is enhanced when fast mode waves couple to the shear Alfven waves. The narrow heating layers are formed near the location of the ideal resonance, which might occur near the coronal hole boundary for a nearly constant density coronal hole, surrounded by a higher density plasma. We investigate the dependence of the heating on the driver frequency, the Lundquist number, and on the heliocentric distance. and find that the low frequency Alfven waves can be an efficient source of heating at large distances from the Sun. We discuss the relation of our results to the observed properties of high-speed solar wind and coronal holes.

Description: We report results from a dynamic approach to equilibrium for a three fluid solar-wind model in spherical 1D. We advance the mass, momentum and energy transport equations for protons, alpha particles and electrons, with full interspecies coulomb coupling and the simplifications recommended by Burgi (1992). They include no ion heat conduction and an ambipolar electric field in place of the negligible electron momentum coupling. At the inner boundary (the solar surface) we specify the inflow velocity, mass flux, and temperature for each species, and at the outer boundary at large radius we allow the fluids to flow freely from the computational domain. Starting from an initial wind model (e.g.. single fluid) we evolve to a three-fluid steady state. We will describe comparisons with Burgi's static equilibrium results. and examine the stability of the discontinuities which appear in his derived parameter variations.

Description: We present a study of a three-fluid solar wind model. with continuity, momentum and separate energy equations for protons. alpha particles and electrons. Allowing separate coronal heat sources for all three species, we study the flow properties of the solar wind as a function of heat input, Alfven wave energy input, and alpha particle abundance.

Description: Petschek's 're-connection' model, aspiring to be universal, treated as a boundary problem meets unresolvable difficulties connected with impossibility to specify correctly boundary and initial conditions. This problem was incorrectly formulated. Hence, ineradicable logarithmic singularities occurred on the boundary surfaces. Attempts to eliminate them by incorporating the finite electrical conductivity are incorrect. This should lead to the change in the equation type, boundary condition type and in consequence to the change in solutions. Besides, the slow mode shocks cannot be driven by small internal source. As an alternative a new plasma concept is suggested. The state of fully ionized plasma in space depends completely on the entropy of the plasma heating source and on the process in which plasma is involved. The presumptive source of the solar wind creation - the induction electric field of the solar origin - has very low entropy. The state of plasma should be very far from the thermodynamic equilibrium. Debye's screening is not complete. The excitation of the powerful resonant self-consistent electric fields in plasma provides low electric conductivity. The MHD problems should be treated in frameworks of dissipative theories.

Description: A nonlinear, time-dependent, ideal MHD code has been developed and used to compute the flow induced by nonlinear Alfven waves propagating in an isothermal, stratified, plane-parallel atmosphere. The code is based on characteristic equations solved in a Lagrangian frame and is highly accurate. Results show that resonance behavior of Alfven waves exists in the presence of a continuous density gradient and that the waves with periods corresponding to resonant peaks exert considerably more force on the medium than off-resonance periods; this leads to enhanced flow. If only off-peak periods are considered, the relationship between the wave period and induced longitudinal velocity shows that short period WKB waves push more on the background medium than longer period, non-WKB, waves. The results also show the development of the longitudinal waves produced by the finite amplitude of the Alfven waves. The longitudinal wave becomes strong as the Alfven wave relative amplitude grows above 10 percent and will lead to strong damping of the Alfven waves.

Description: The calculation of the solar rotation electro-dynamical effects in the near-the-Sun solar wind seems more convenient from the non-inertial corotating reference frame. This implies some modification of the 3-D MHD equations generally on the base of the General Theory of Relativity. The paper deals with the search of stationary (in corotating non-inertial reference frame) solutions of the modified 3-D MHD equations for the in near-the-Sun high latitude sub-alfvenic solar wind. The solution is obtained requiring electric fields and field-aligned electric currents in the high latitude near-the-Sun solar wind. Various scenario are explored self-consistently via a number of numerical experiments. The analogy with the high latitude Earth's magnetosphere is used for the interpretation of the results. Possible observational manifestations are discussed.

Description: A fully three-dimensional solar wind model that incorporates momentum and heat addition from Alfven waves is developed. The proposed model upgrades the previous one by considering self-consistently the total system consisting of Alfven waves propagating outward from the Sun and the mean polytropic solar wind flow. The simulation region extends from the coronal base (1 R(sub s) out to beyond 1 AU. The fully 3-D MHD equations written in spherical coordinates are solved in the frame of reference corotating with the Sun. At the inner boundary, the photospheric magnetic field observations are taken as boundary condition and wave energy influx is prescribed to be proportional to the magnetic field strength. The results of the model application for several time intervals are presented.

Description: Anomalous cosmic rays (ACRs) are interstellar neutrals that drift into the heliosphere, become singly ionized, and are convected to the termination shock of the solar wind, where they are thought to be accelerated to hundreds of MeV. Because their effective origin is at the termination shock, studies of their gradients and spectral shape can reveal important clues about the shock's location, its strength, and the source flux of ACRs. Recently, such studies have predicted that one or more of the Voyager and Pioneer spacecraft may cross the termination shock in the next few years. In addition, there have been studies of galactic cosmic rays that shed new light on the location of the modulation boundary of these particles, which may be the heliopause region. In this talk, we will review these observations and the information they provide about the boundaries of the heliosphere.

Description: The solar corona, modelled by a low beta, resistive plasma slab, sustains MHD wave propagations due to shearing footpoint motions in the photosphere. By using a numerical algorithm the excitation and nonlinear development of MHD waves in twisted coronal loops are studied. The plasma responds to the footpoint motion by sausage waves if there is no twist. The twist in the magnetic field of the loop destroys initially developed sausage-like wave modes and they become kinks. The transition from sausage to kink modes is analyzed. The twist brings about mode degradation producing high harmonics and this generates more complex fine structures. This can be attributed to several local extrema in the perturbed velocity profiles. The Alfven wave produces remnants of the ideal 1/x singularity both for zero and non-zero twist and this pseudo-singularity becomes less pronounced for larger twist. The effect of nonlinearity is clearly observed by changing the amplitude of the driver by one order of magnitude. The magnetosonic waves also exhibit smoothed remnants of ideal logarithmic singularities when the frequency of the driver is correctly chosen. This pseudo-singularity for fast waves is absent when the coronal loop does not undergo any twist but becomes pronounced when twist is included. On the contrary, it is observed for slow waves even if there is no twist. Increasing the twist leads to a higher heating rate of the loop. The larger twist shifts somewhat uniformly distributed heating to layers inside the slab corresponding to peaks in the magnetic field strength.

Description: Faraday rotation (FR) measurements using linearly polarized radio signals from the two Helios spacecraft were carried out during the period from 1975 to 1984. This paper presents the results of a spectral analysis of the Helios S-band FR fluctuations observed at heliocentric distances from 2.6 to 15 solar radii during the superior conjunctions 1975-1983. The mean intensity of the FR fluctuations does not exceed the noise level for solar offsets greater than ca. 15 solar radii. The rms FR fluctuation amplitude increases rapidly as the radio ray path approaches the Sun, varying according to a power law (exponent: 2.85 +/- 0.15) at solar distances 4-12 solar radii. At distances inside 4 solar radii the increase is even steeper (exponent: 5.6 +/- 0.2). The equivalent two-dimensional FR fluctuation spectrum is well modeled by a single power-law over the frequency range from 5 to 50 mHz. For heliocentric distances larger than 4 solar radii the spectral index varies between 1.1 and 1.6 with a mean value of 1.4 +/- 0.2, corresponding to a 3-D spectral index p = 2.4. FR fluctuations thus display a somwhat lower spectral index compared with phase and amplitude fluctuations. Surprisingly high values of the spectral index were found for measurements inside 4 solar radii (p = 2.9 +/- 0.2). This may arise from the increasingly dominant effect of the magnetic field on radio wave propagation at small solar offsets. Finally, a quasiperiodic component, believed to be associated with Alfven waves, was discovered in some (but not all!) fluctuation spectra observed simultaneously at two ground stations. Characteristic periods and bulk velocities of this component were 240 +/- 30 sec and 300 +/- 60 km/s, respectively.

Description: Filamentary magnetic fields and intermittent mass flows with highly variant physical parameters as observed in coronal holes provide, from a theoretical point of view, natural conditions for strongly nonlinear dynamics. The presence of sheared mass flows along fine scale magnetic structures results in strong nonlinear instability, most important of which is the explosive instability. We specify the physical conditions for several different manifestations of the onset of explosive instability and its further evolution: (1) fully developed explosive instability - explosive release of the energy; (2) shock formation - stabilization of instability by small scale spatial inhomogeneities leads to formation of subsequent shocks having a number of peculiarities that is determined by the interplay of thermal and viscous losses (for example, in predominance of thermal losses the isothermal jump occurs); and (3) solitary waves - stabilization of explosive instability by nonlinear dispersion effect leads to formation of a 'gas' of solitons which are later either damped away with characteristic time and energy input or evolve to solitons with explosively growing amplitudes. Each scenario is completely determined by the physical parameters of the medium, thus producing a quite uneven distribution of energy in a coronal hole and, respectively, an uneven outward propagation of the energy flux.

Description: The Soft X-ray Telescope (SXT) aboard Yohkoh has revealed that the solar corona is much more dynamic that had been thought. Among various newly discovered dynamic phenomena, one of the most surprising findings is the discovery of coronal x-ray jets. The length of these jets is a few 10(exp 3) - a few 10(exp 5) km, their (apparent) velocity is a few 10 - a few 100 km/s (some reached 1000 km/s), and the corresponding kinetic energy is estimated to be 10(exp 25) - 10(exp 28) erg. They occur in association with small flares in active regions, emerging flux regions, and x-ray bright points, and show the following common characteristics: recurrency, whip-like motion, change in morphology at the footpoint ARs, and often converging (or inverted-Y) shape. Large scale loop brightenings observed by SXT seem to correspond to jets occurring in closed loop systems. These observations suggest that the magnetic reconnection between the emerging magnetic flux (or expanding loop) and the overlying coronal/chromospheric magnetic field is a key physical process for producing these jets. We shall summarize characteristics of these coronal X-ray jets observed by SXT, and also discuss the theoretical interpretation of them, especially in the framework of a magnetic reconnection model.

Description: We used weak electric fields to monitor macrophage spreading in microgravity. Using this technique, we demonstrated that bone marrow-derived macrophages responded to microgravity within 8 s. We also showed that microgravity differentially altered two processes associated with bone marrow-derived macrophage development. Spaceflight enhanced cellular proliferation and inhibited differentiation. These data indicate that the space/microgravity environment significantly affects macrophages.

Description: Intramuscular fluid pressure (IMP) can easily be measured in man and animals. It follows the law of Laplace which means that it is determined by the tension of the muscle fibers, the recording depth and by fiber geometry (fiber curvature or pennation angle). Thick, bulging muscles create high IMPs (up to 1000 mmHg) and force transmission to tendons becomes inefficient. High resting or postexercise IMPs are indicative of a compartment syndrome due to muscle swelling within a low-compliance osseofascial boundary. IMP increases linearly with force (torque) independent of the mode or speed of contraction (isometric, eccentric, concentric). IMP is also a much better predictor of muscle force than the EMG signal. During prolonged low-force isometric contractions, cyclic variations in IMP are seen. Since IMP influences muscle blood flow through the muscle pump, autoregulating vascular elements, and compression of the intramuscular vasculature, alterations in IMP have important implications for muscle function.

Description: Astronauts often experience back pain during spaceflight. Retrospectively, Wing et al. (14) found that during spaceflight, 14 of 19 Shuttle crewmembers experienced back pain, which they described as dull (62%), localized to the lower back (50%), and with an intensity of 2 on a 5-point scale. Further, the spine lengthens 4-7 cm in microgravity. Our objective was to compare back pain and spinal lengthening (body height increase) during simulated microgravity (6 degrees head-down tilt, HDT) with the same parameters during actual microgravity. Eight male subjects completed a modified McGill pain questionnaire with intensity graded from zero (no pain) to five (intense and incapacitating pain) each day at 7:00 pm during 2 d pre-HDT control, 16 d HDT, and 1 d post-HDT recovery periods. Also, the subjects' heights were measured each day while supine (control and recovery) and during HDT. Back pain increased from zero (pre-tilt control period) to 2.3 +/- 0.4 at days 1 to 3 of HDT, and was categorized as dull and/or burning pain in subjects' lower backs. Only 2 subjects reported any pain after day 9 of HDT and during recovery. Heights increased 2.1 +/- 0.5 cm by day 3 of HDT and remained at that level until the end of the HDT period. Although spinal lengthening in space is greater than that during HDT, the HDT model approximates the level, type, distribution, and time course of back pain associated with actual microgravity. In the HDT model, pain subsides in intensity when spinal lengthening stops.(ABSTRACT TRUNCATED AT 250 WORDS).

Description: To determine whether estimates of volumetric bone density from projectional scans of the lumbar spine have weaker associations with height and weight and stronger associations with prevalent vertebral fractures than standard projectional bone mineral density (BMD) and bone mineral content (BMC), we obtained posteroanterior (PA) dual X-ray absorptiometry (DXA), lateral supine DXA (Hologic QDR 2000), and quantitative computed tomography (QCT, GE 9800 scanner) in 260 postmenopausal women enrolled in two trials of treatment for osteoporosis. In 223 women, all vertebral levels, i.e., L2-L4 in the DXA scan and L1-L3 in the QCT scan, could be evaluated. Fifty-five women were diagnosed as having at least one mild fracture (age 67.9 +/- 6.5 years) and 168 women did not have any fractures (age 62.3 +/- 6.9 years). We derived three estimates of "volumetric bone density" from PA DXA (BMAD, BMAD*, and BMD*) and three from paired PA and lateral DXA (WA BMD, WA BMDHol, and eVBMD). While PA BMC and PA BMD were significantly correlated with height (r = 0.49 and r = 0.28) or weight (r = 0.38 and r = 0.37), QCT and the volumetric bone density estimates from paired PA and lateral scans were not (r = -0.083 to r = 0.050). BMAD, BMAD*, and BMD* correlated with weight but not height. The associations with vertebral fracture were stronger for QCT (odds ratio [QR] = 3.17; 95% confidence interval [CI] = 1.90-5.27), eVBMD (OR = 2.87; CI 1.80-4.57), WA BMDHol (OR = 2.86; CI 1.80-4.55) and WA-BMD (OR = 2.77; CI 1.75-4.39) than for BMAD*/BMD* (OR = 2.03; CI 1.32-3.12), BMAD (OR = 1.68; CI 1.14-2.48), lateral BMD (OR = 1.88; CI 1.28-2.77), standard PA BMD (OR = 1.47; CI 1.02-2.13) or PA BMC (OR = 1.22; CI 0.86-1.74). The areas under the receiver operating characteristic (ROC) curves for QCT and all estimates of volumetric BMD were significantly higher compared with standard PA BMD and PA BMC. We conclude that, like QCT, estimates of volumetric bone density from paired PA and lateral scans are unaffected by height and weight and are more strongly associated with vertebral fracture than standard PA BMD or BMC, or estimates of volumetric density that are solely based on PA DXA scans.

Description: Ionizing radiation poses a significant risk to humans living and working in space. The major sources of radiation are solar disturbances and galactic cosmic rays. The components of this radiation are energetic charged particles, protons, as well as fully ionized nuclei of all elements. The biological effects of these particles cannot be extrapolated in a straightforward manner from available data on x-rays and gamma-rays. A radiation protection program that meets the needs of spacefaring nations must have a solid scientific basis, capable not only of predicting biological effects, but also of making reliable estimates of the uncertainty in these predictions. A strategy leading to such predictions is proposed, and scientific requirements arising from this strategy are discussed.

Description: BACKGROUND AND PURPOSE: Presyncope, characterized by symptoms and signs indicative of imminent syncope, can be aborted in many situations before loss of consciousness occurs. The plasticity of cerebral autoregulation in healthy humans and its behavior during this syncopal prodrome are unclear, although systemic hemodynamic instability has been suggested as a key factor in the precipitation of syncope. Using lower body negative pressure (LBNP) to simulate central hypovolemia, we previously observed falling mean flow velocities (MFVs) with maintained mean arterial blood pressure (MABP). These findings, and recent reports suggesting increased vascular tone within the cerebral vasculature at presyncope, cannot be explained by the classic static cerebral autoregulation curve; neither can they be totally explained by a recent suggestion of a rightward shift in this curve. METHODS: Four male and five female healthy volunteers were exposed to presyncopal LBNP to evaluate their cerebrovascular and cardiovascular responses by use of continuous acquisition of MFV from the right middle cerebral artery with transcranial Doppler sonography, MABP (Finapres), and heart rate (ECG). RESULTS: At presyncope, MFV dropped on average by 27.3 +/- 14% of its baseline value (P 〈 .05), while MABP remained at 2.0 +/- 27% above its baseline level. Estimated cerebrovascular resistance increased during LBNP. The percentage change from baseline to presyncope in MFV and MABP revealed consistent decreases in MFV before MABP. CONCLUSIONS: Increased estimated cerebrovascular resistance, falling MFV, and constant MABP are evidence of an increase in cerebral vascular tone with falling flow, suggesting a downward shift in the cerebral autoregulation curve. Cerebral vessels may have a differential sensitivity to sympathetic drive or more than one type of sympathetic innervation. Future work to induce dynamic changes in MABP during LBNP may help in assessing the plasticity of the cerebral autoregulation mechanism.

Description: Growth, functional adaptation, and torsional strength were examined in the femora of 39-day-old male Sprague-Dawley rats subjected to hindlimb suspension for 0, 1, 2, 3, or 4 weeks and were compared with measurements for age-matched control animals. Our goal was to understand the effect of reduced loading on the normal age-related changes in femoral properties during growth. The control animals exhibited growth-related increases in all geometric and torsional properties of the femur. The mean body mass and femoral length of the hindlimb-suspended rats were similar to those of the controls throughout the experiment. Over 4 weeks, the femoral cross-sectional and torsional measurements from the hindlimb-suspended rats demonstrated increases in comparison with the basal values (+33% cross-sectional area, +64% polar moment of inertia, +67% ultimate torque, and +181% torsional rigidity), but the age-matched controls showed significantly greater growth-related increases (+71% cross-sectional area, +136% polar moment of inertia, +127% ultimate torque, and +367% torsional rigidity). The differences in femoral structural strength between the hindlimb-suspended animals and the age-matched controls were attributable to differences in altered cross-sectional geometry.

Description: STUDY DESIGN. Muscle use evoked by exercise was determined by quantifying shifts in signal relaxation times of T2-weighted magnetic resonance images. Images were collected at rest and after exercise at each of two intensities (moderate and intense) for each of four head movements: 1) extension, 2) flexion, 3) rotation, and 4) lateral flexion. OBJECTIVE. This study examined the intensity and pattern of neck muscle use evoked by various movements of the head. The results will help elucidate the pathophysiology, and thus methods for treating disorders of the cervical musculoskeletal system. SUMMARY OF BACKGROUND DATA. Exercise-induced contrast shifts in T2 has been shown to indicate muscle use during the activity. The noninvasive nature of magnetic resonance imaging appears to make it an ideal approach for studying the function of the complex neuromuscular system of the neck. METHODS. The extent of T2 increase was examined to gauge how intensely nine different neck muscles or muscle pairs were used in seven subjects. The absolute and relative cross-sectional area of muscle showing a shift in signal relaxation was assessed to infer the pattern of use among and within individual neck muscles or muscle pairs. RESULTS. Signal relaxation increased with exercise intensity for each head movement. The absolute and relative cross-sectional area of muscle showing a shift in signal relaxation also increased with exercise load. Neck muscles or muscle pairs extensively used to perform each head movement were: extension--semispinalis capitis and cervicis and splenius capitis; flexion--sternocleidomastoid and longus capitis and colli; rotation--splenius capitis, levator scapulae, scalenus, semispinalis capitis ipsilateral to the rotation, and sternocleidomastoid contralateral; and lateral flexion--sternocleidomastoid CONCLUSION. The results of this study, in part, agree with the purported functions of neck muscles derived from anatomic location. This also was true for the few selected muscles that have been examined in human electromyographic studies. Neck muscle function and morphology can be studied at a detailed level using exercise-induced shifts in magnetic resonance images.

Description: Radiation risks to astronauts depend on the microscopic fluctuations of energy absorption events in specific tissues. These fluctuations depend not only on the space environment but also on the modifications of that environment by the shielding provided by structures surrounding the astronauts and the attenuation characteristics of the astronaut's body. The effects of attenuation within the shield and body depends on the tissue biological response to these microscopic fluctuations. In the absence of an accepted method for estimating astronaut risk, we examined the attenuation characteristics using conventional linear energy transfer (LET)-dependent quality factors (as one means of representing relative biological effectiveness, RBE) and a track-structure repair model to fit cell transformation (and inactivation) data in the C3H10 T1/2 mouse cell system obtained for various ion beams. Although the usual aluminum spacecraft shield is effective in reducing dose equivalent with increasing shield thickness, cell transformation rates are increased for thin aluminum shields. Clearly, the exact nature of the biological response to LET and track width is critical to evaluation of biological protection factors provided by a shield design. A significant fraction of biological injury results from the LET region above 100 keV/mu m. Uncertainty in nuclear cross-sections results in a factor of 2-3 in the transmitted LET spectrum beyond depths of 15 g/cm2, but even greater uncertainty is due to the combined effects of uncertainty in biological response and nuclear parameters. Clearly, these uncertainties must be reduced before the shield design can be finalised.

Description: The healthy heartbeat is traditionally thought to be regulated according to the classical principle of homeostasis whereby physiologic systems operate to reduce variability and achieve an equilibrium-like state [Physiol. Rev. 9, 399-431 (1929)]. However, recent studies [Phys. Rev. Lett. 70, 1343-1346 (1993); Fractals in Biology and Medicine (Birkhauser-Verlag, Basel, 1994), pp. 55-65] reveal that under normal conditions, beat-to-beat fluctuations in heart rate display the kind of long-range correlations typically exhibited by dynamical systems far from equilibrium [Phys. Rev. Lett. 59, 381-384 (1987)]. In contrast, heart rate time series from patients with severe congestive heart failure show a breakdown of this long-range correlation behavior. We describe a new method--detrended fluctuation analysis (DFA)--for quantifying this correlation property in non-stationary physiological time series. Application of this technique shows evidence for a crossover phenomenon associated with a change in short and long-range scaling exponents. This method may be of use in distinguishing healthy from pathologic data sets based on differences in these scaling properties.

Description: One physiologic consequence of extended periods of weightlessness is the rapid loss of bone mass associated with skeletal unloading. Conversely, mechanical loading has been shown to increase bone formation and stimulate osteoblastic function. The mechanisms underlying mechanotransduction, or how the osteoblast senses and converts biophysical stimuli into cellular responses has yet to be determined. For non-innervated mechanosensitive cells like the osteoblast, mechanotransduction can be divided into four distinct phases: 1) mechanocoupling, or the characteristics of the mechanical force applied to the osteoblast, 2) biochemical coupling, or the mechanism through which mechanical strain is transduced into a cellular biochemical signal, 3) transmission of signal from sensor to effector cell and 4) the effector cell response. This review examines the characteristics of the mechanical strain encountered by osteoblasts, possible biochemical coupling mechanisms, and how the osteoblast responds to mechanical strain. Differences in osteoblastic responses to mechanical strain are discussed in relation to the types of strain encountered and the possible transduction pathways involved.

Description: The differentiaton of bone cells is a complex multistep process. Bone is somewhat unusual in that it is very actively and continually remodeled in the adult and that maintenance of its mass in the mature organism is exquisitely sensitive to mechanical as well as chemical signals. Bone is also unique because it consists of a very large amount of extracellular matrix (ECM) that is mineralized. The integrin family of ECM receptors has been shown to play an important role in tissue morphogenesis in several systems. Our studies on the regulation of matrix remodeling enzymes by integrins in rabbit synovial fibroblasts show that two b1 integrin fibronectin (FN) receptor complexes (alpha 5 beta 1 and alpha 4 beta 1) cooperate in detecting subtle changes in the composition of the ECM. As a result of signal transduction by these integrins, the levels of mRNA and protein for several members of the metalloproteinase family are regulated in these cells. We have also used antibody and RGD peptide perturbation studies to determine the significance of cell/ECM interactions to normal osteogenesis. We found that interactions between the cell binding domain of FN and integrins are required for both normal morphogenesis and gene expression in cultured osteoblasts that differentiate to form bone-like tissue in culture. These data lead us to propose that beta 1 integrins play an important role in osteoblast differentiation as well as in bone remodeling.

Description: The most studied skeletal muscles which depend on gravity, "antigravity" muscles, are located in the posterior portion of the legs. Antigravity muscles are characterized generally by a different fiber type composition than those which are considered nonpostural. The gravity-dependent function of the antigravity muscles makes them particularly sensitive to weightlessness (unweighting) resulting in a substantial loss of muscle protein, with a relatively greater loss of myofibrillar (structural) proteins. Accordingly alpha-actin mRNA decreases in muscle of rats exposed to microgravity. In the legs, the soleus seems particularly responsive to the lack of weight-bearing associated with space flight. The loss of muscle protein leads to a decreased cross-sectional area of muscle fibers, particularly of the slow-twitch, oxidative (SO) ones compared to fast-twitch glycolytic (FG) or oxidative-glycolytic (FOG) fibers. In some muscles, a shift in fiber composition from SO to FOG has been reported in the adaptation to spaceflight. Changes in muscle composition with spaceflight have been associated with decreased maximal isometric tension (Po) and increased maximal shortening velocity. In terms of fuel metabolism, results varied depending on the pathway considered. Glucose uptake, in the presence of insulin, and activities of glycolytic enzymes are increased by space flight. In contrast, oxidation of fatty acids may be diminished. Oxidation of pyruvate, activity of the citric acid cycle, and ketone metabolism in muscle seem to be unaffected by microgravity.

Description: The purpose of this study was to compare the effects of hypergravity exposure (2g) with those of exposure to space flight in the Cosmos 2044 flight. To do so, rats were centrifuged continuously for 14 days. Two different experiments were carried out on tissue obtained from the centrifuged rats. In the first experiment, rat bone marrow cells were examined for their response to recombinant murine colony stimulating factor-granulocyte/monocyte (GM-CSF). In the second experiment, rat spleen and bone marrow cells were stained in with a variety of antibodies directed against cell surface antigenic markers. These cells were preserved and analyzed on a flow cytometer. The results of the studies indicated that bone marrow cells from centrifuged rats showed no significant change in response to GM-CSF as compared to bone marrow cells from control rats. Spleen cells from flown rats showed some statistically significant changes in leukocytes subset distribution, but no differences that appeared to be of biological significance. These results indicate that hypergravity did not greatly affect the same immunological parameters affected by space flight in the Cosmos 2044 mission.

Description: The effective transverse relaxation time T2* is influenced by the presence of trabecular bone, and can potentially provide a measure of bone density as well as bone structure. We determined the in vivo precision of T2* in repeated bone marrow measurements. The T2* measurements of the bone marrow of the distal radius were performed twice within 2 weeks in six healthy young volunteers using a modified water-presaturated 3D Gradient-Recalled Acquisition at Steady State (GRASS) sequence with TE 7, 10, 12, 20, and 30; TR 67; flip angle (FA) 90 degrees. An axial volume covering a length of 5.6 cm in the distal radius was measured. Regions of interest (ROIs) were determined manually and consisted of the entire trabecular bone cross-section extending proximally from the radial subchondral endplate. Reproducibility of T2* and area measurements was expressed as the absolute precision error (standard deviation [SD] in ms or mm2) or as the relative precision error (SD/mean x 100, or coefficient of variation [CV] in %) between the two-point measurements. Short-term precision of T2* and area measurements varied depending on section thickness and location of the ROI in the distal radius. Absolute precision errors for T2* times were between 1.3 and 2.9 ms (relative precision errors 3.8-9.5 %) and for area measurements between 20 and 55 mm2 (relative precision errors 5.1-16.4%). This MR technique for quantitative assessment of trabecular bone density showed reasonable reproducibility in vivo and is a promising future tool for the assessment of osteoporosis.

Description: Recent improvements in the radiation transport code HZETRN/BRYNTRN and galactic cosmic ray environmental model have provided an opportunity to investigate the effects of target fragmentation on estimates of single event upset (SEU) rates for spacecraft memory devices. Since target fragments are mostly of very low energy, an SEU prediction model has been derived in terms of particle energy rather than linear energy transfer (LET) to account for nonlinear relationship between range and energy. Predictions are made for SEU rates observed on two Shuttle flights, each at low and high inclination orbit. Corrections due to track structure effects are made for both high energy ions with track structure larger than device sensitive volume and for low energy ions with dense track where charge recombination is important. Results indicate contributions from target fragments are relatively important at large shield depths (or any thick structure material) and at low inclination orbit. Consequently, a more consistent set of predictions for upset rates observed in these two flights is reached when compared to an earlier analysis with CREME model. It is also observed that the errors produced by assuming linear relationship in range and energy in the earlier analysis have fortuitously canceled out the errors for not considering target fragmentation and track structure effects.

Description: Increased sensitivity of end-organ responses to neuroendocrine stimuli as a result of prolonged exposure to the relative inactivity of microgravity has recently been hypothesized. This notion is based on the inverse relationship between circulating norepinephrine and beta-adrenoreceptor sensitivity. The beta-adrenoreceptor activity is reduced in individuals who have elevated plasma norepinephrine as a result of regular exposure to upright posture and physical exercise. In contrast, adrenoreceptor hypersensitivity has been reported in patients with dysautonomias in which circulating catecholamines are absent or reduced. Taken together, these studies and the observation that circulating plasma norepinephrine has been reduced during spaceflight and in groundbased simulations of microgravity prompt the suggestion that adrenoreceptor hypersensitivity may be a consequence of the adaptation to spaceflight. We conducted an experiment designed to measure cardiovascular responses to adrenoreceptor agonists in human subjects before and after prolonged exposure to 6 deg head-down tilt (HDT) to test the hypothesis that adaptation to microgravity increases adrenoreceptor responsiveness, and that this adaptation is associated with reduced levels of circulating norepinephrine.

Description: No abstract available

Description: Measurements of the energy spectra of secondary particles produced by galactic cosmic rays and trapped protons due to the nuclear interactions of these particles with the Shuttle shielding provide a powerful tool for validating radiation transport codes. A code validated in this way can be used to better estimate the dose and dose equivalent to body organs, measurements that cannot be made directly. The principal cause of single event upsets in electronic devices in the region of the South Atlantic Anomaly is secondary particles, and even in the region of galactic cosmic radiation a significant fraction is produced by secondary particles. In this paper, we describe the first direct measurements of the energy spectra of secondary protons, deuterons, tritons, 3He and 4He produced by galactic cosmic rays inside the Space Shuttle using a charged particle spectrometer. A comparison of these spectra with radiation transport code HZETRN showed reasonably good agreement for secondary protons. However, the code seriously underestimated the flux of all other light ions. The code has been modified to include pick-up and knock-on processes. The modified code leads to good agreement for deuterons and 3He but not for other light ions. This revised code leads to about 10% higher dose equivalent than the original code under moderate shielding, if we assume that higher charge ion fluxes are correctly predicted by the model.

Description: We review historical and methodological approaches to measurements of intramuscular pressure (IMP) in humans. These techniques provide valuable measures of muscle tone and activity as well as diagnostic criteria for evaluation of exertional compartment syndrome. Although the wick and catheter techniques provide accurate measurements of IMP at rest, their value for exercise studies and diagnosis of exertional compartment syndrome is limited because of low frequency response and hydrostatic (static and inertial) pressure artifacts. Presently, most information on diagnosis of exertional compartment syndromes during dynamic exercise is available using the Myopress catheter. However, future research and clinical diagnosis using IMP can be optimized by the use of a miniature transducer-tipped catheter such as the Millar Mikro-tip.

Description: We have investigated more than 450 coronal mass ejections (CME's) observed between 1979-1985 (by SOLWIND) having speed more than 500 km/s. To carry out the study we have used the method of time and spatial correlations. From the study we have found the following: (1) About 50% CMEs are related with coronal holes; (2) About 15% CMEs are related with solar flares; (3) About 25% CMEs are associated with eruptive prominence; and (4) About 10% CMEs are not related with any solar phenomena. The relationship of CMEs and solar radio bursts are also studied. In the light of above, we are of the view that there may be two types of CMEs. The origin of one of them may be related with coronal holes and that for other may be solar flares and prominences.

Description: We are designing a Solar Mass Ejection Imager (SMEI) capable of observing the Thomson-scattered signal from transient density features in the heliosphere from a spacecraft situated near AU. The imager is designed to trace these features, which include coronal mass ejections. corotating structures and shock waves, to elongations greater than 90 deg from the Sun. The instrument may be regarded as a progeny of the heliospheric imaging capability shown possible by the zodiacal-light photometers of the HELIOS spacecraft. The instrument we are designing would make more effective use of in-situ solar wind data from spacecraft in the vicinity of the imager by extending these observations to the surrounding environment. The observations from the instrument should allow deconvolution of these structures from the perspective views obtained as they pass the spacecraft. An imager at Earth could allow up to three days warning of the arrival of a mass ejection from the Sun .

Description: The radio and plasma wave receivers on the Ulysses spacecraft have detected thousands of short-duration bursts of waves at approximately the electron plasma frequency. These wave events believed to be Langmuir waves are usually less than approximately 5 minutes in duration. They occur in or at the boundaries of depletions in the magnetic field amplitude known as magnetic holes. Using the 16 sec time resolution provided by the plasma frequency receiver, it is possible to examine the density structure inside of magnetic holes. Even higher time resolutions are sometimes available from the radio receiver data. The Ulysses observations show that these wave bursts occur more frequently at high heliographic latitudes; the occurrence rates depend on both latitude and distance from the Sun. We review the statistics for the wave events, compare them to magnetic and plasma parameters, and review the reasons for the more frequent occurrence at high heliographic latitudes.

Description: One of the most important parameters in MHD description of the solar wind is the electric conductivity of plasma. There exist now two quite different approaches to the evaluation of this parameter. In the first one a value of conductivity taken from the most elaborated current theory of plasma should be used in calculations. The second one deals with the empirical, phenomenological value of conductivity. E.g.: configuration of interplanetary magnetic field, stretched by the expanding corona, depends on the magnitude of electrical conductivity of plasma in the solar wind. Knowing the main empirical features of the field configuration, one may estimate the apparent phenomenological value of resistance. The estimations show that the electrical conductivity should be approximately 10(exp 13) times smaller than that calculated by Spitzer. It must be noted that the empirical value should be treated with caution. Due to the method of its obtaining it may be used only for 'large-scale' description of slow processes like coronal expansion. It cannot be valid for 'quick' processes, changing the state of plasma, like collisions with obstacles, e.g., planets and vehicles. The second approach is well known in large-scale planetary hydrodynamics, stemming from the ideas of phenomenological thermodynamics. It could formulate real problems which should be solved by modern plasma physics, oriented to be adequate for complicated processes in space.

Description: Between 1 and 2 solar radii, the Coulomb-collision mean free path for thermal ions exceeds the scale height of the solar atmosphere. The expanding solar plasma becomes collisionless and the kinetics of the solar wind are no longer dominated by thermalizing collisions. The usual Braginskii-type expressions for solar wind ion heat flux and viscosity are no longer valid. However, another microscale still exists in the solar wind, dictated by the gyro-radius of ions in the turbulent embedded solar wind magnetic field. Wave-particle interactions will act to isotropize (but not thermalize) particle distributions, and the relevant microscale for this process is the ion gyro-radius. The ion distribution can be modelled as undergoing isotropizing 'collisions,' with the relevant mean free path scaling with gyro-radius. Here, the author presents the heat flux and viscosity expected for solar wind protons which are relaxing to isotropy on a microscale that scales with gyro-radius. The collisionless viscosity and heat flux have a functional dependence different than their collisional analogs. The collisional expressions for ion viscosity and heat flux drastically overestimate the efficiency of diffusive energy and momentum transport actually operative in the solar wind.

Description: The abundance of helium in the solar wind averages approximately 4% but has been observed to vary by more than two orders of magnitude from 0.1 to 30%. Physical processes responsible for this variability are still not clearly understood. Previous work has shown a correlation between low He abundance and coronal streamer plasma and between high He abundance and coronal mass ejections (CMEs). We now have out-of-ecliptic data on helium in the solar wind from the plasma experiment aboard Ulysses. Tentative results show that the average high-latitude helium concentration is comparable to the in-ecliptic value for the present phase of the solar cycle, that excursions of the hour-averaged abundance very seldom fall outside the range 2.5 to 6.5%, and that there seems to be very little abundance enhancement associated with CMEs encountered at latitudes greater than 30 deg as opposed to the situation commonly encountered with in-ecliptic CMEs. In addition, preliminary observations of a single CME by both ISEE (in-ecliptic) and Ulysses (out-of-ecliptic) show a considerable He enhancement at ISEE with little or no perturbation of the average value at Ulysses' location. This paper will first present new results from the Ulysses mission up to the time of the meeting on the average abundance of helium in the solar wind as a function of spacecraft position, and will then focus on the out-of-ecliptic results including latitudinal abundance variations and observations of abundance enhancements (or lack thereof) in high-latitude CMEs.

Description: The ESA-NASA satellite, to be launched in October 1995, carries three nested coronagraphs, which will image the solar corona from 1.1 R(solar mass) to 30 R(solar mass). Super polished mirrors have been developed for the design of a mirror Lyot coronagraph which has a straylight level comparable with the coronal intensity from 1.1 R, to 30 R(solar mass) Coronal details can be imaged with a spatial resolution of 6 arc seconds. A Fabry Perot interferometer with a spectral resolution of 0.7 A at the wavelength of the green coronal emission line will allow the simultaneous construction of spectra over the entire field of view of 10(exp 6) pixels. The middle coronagraph (1.5 R(solar mass) - 6 R(solar mass)) and the outer coronagraph (3 R(solar mass) - 30 R(solar mass)) are externally occulted lens Lyot coronagraphs. Their straylight level 10(exp -11) B(solar mass) and 10(exp -12) B(solar mass) respectively is an order of magnitude smaller than the intensity of the corona. The sensitivity of LASCO to distinguish between different solar wind acceleration mechanisms will be discussed as well as its ability to discern different CME models.

Description: We present new calculations for several solar ions in the temperature range 10(exp 5) is less than T is less than 10(exp 6) K and discuss their diagnostic applications with the help of available observational data. In particular, we rediscuss the plasma density and temperature in the source region of the solar wind. We also study the variation of relative elemental abundances in the solar atmosphere and compare them with previous studies.

Description: The difficulty in establishing the temperature structure and temperature gradient within coronal holes from limb observations is due to the frequent veiling of coronal holes by hotter and denser quiet regions often surrounding them and shaping their boundaries. Nevertheless probing the coronal hole medium itself can be made with a judicious choice of spectral lines. We show how a set of visible forbidden Fe lines, namely Fe IX 3801, Fe X 6374 and Fe Xl 7892 A which are sensitive to plasma temperatures less than or equal to 10(exp 6) K can achieve this purpose. We propose to use these lines in a coordinated manner with coronagraph observations. In addition observations made with the Fe XIV 5303 A line should yield information about any hot material intercepting the line of sight. The proposed combination of these Fe lines offers a very powerful diagnostic tool for coronal hole temperatures and structures.

Description: Due to the rotation of the sun the solar corona can be observed under different directions at different times. Using methods of computer tomography the three-dimensional structure of the emissivity of the solar corona can be reconstructed. We discuss the feasibility of this method for stationary and for non-stationary corona and also for incomplete and finite resolution data. As example we present reconstructions based on YOHKOH-images, and we compare the results with ground-based optical corona observations. Structures are interpreted in terms of the solar magnetic field topology.

Description: The universal induction heating mechanism supplying with the energy all the processes of coronal heating and the solar wind acceleration is developed. The observed relative 'trembling' of photospheric super-large scale magnetic fields with quasi-periods of 1-4 days amounts 30-40 percent in amplitude. The inductive electric field appears in the corona. The electric currents cause the Joule dissipation. The uneven heating leads to the solar wind acceleration. A model is suggested in which high-speed streams in space are caused by the combination of the enhanced inductive energy flux from the solar coronal active regions; the work against the regular magnetic field; losses from coronal emission. The consideration is made in terms of the dissipative solar wind theory with the finite electrical conductivity of plasma. The leakage of plasma and the energy flux across the magnetic field, caused by the induction heating processes, are taken into account. The polar coronal holes (and the mid-latitude ones) are indicators of energy transfer balance but not direct sources of high-speed streams in the solar wind.

Description: Heat conduction from the corona is important in the solar wind energy budget. Until now all hydrodynamic solar wind models have been using the collisionally dominated gas approximation for the heat conductive flux. Observations of the solar wind show particle distribution functions which deviate significantly from a Maxwellian, and it is clear that the solar wind plasma is far from collisionally dominated. We have developed a numerical model for the solar wind which solves the full equation for the heat conductive flux together with the conservation equations for mass, momentum, and energy. The equations are obtained by taking moments of the Boltzmann equation, using an 8-moment approximation for the distribution function. For low-density solar winds the 8-moment approximation models give results which differ significantly from the results obtained in models assuming the gas to be collisionally dominated. The two models give more or less the same results in high density solar winds.