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  • Kinetics  (72)
  • American Association for the Advancement of Science (AAAS)  (61)
  • Springer  (11)
  • National Academy of Sciences
  • Periodicals Archive Online (PAO)
  • 1995-1999
  • 1985-1989  (24)
  • 1980-1984  (48)
  • 1955-1959
  • 1985  (24)
  • 1982  (48)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (61)
  • Springer  (11)
  • National Academy of Sciences
  • Periodicals Archive Online (PAO)
Years
  • 1995-1999
  • 1985-1989  (24)
  • 1980-1984  (48)
  • 1955-1959
Year
  • 1
    Electronic Resource
    Electronic Resource
    Influence of a precooling on the nucleation kinetics of ice from water droplets (1982)
    Springer
    Colloid & polymer science 260 (1982), S. 641-642 
    Details
    ISSN: 1435-1536
    Keywords: Kinetics ; Nucleation ; Water ; Emulsion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01422599
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  • 2
    Electronic Resource
    Electronic Resource
    Investigating the kinetics of the adsorption process of polyamideamine on cellulose (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 720-725 
    Details
    ISSN: 1435-1536
    Keywords: Kinetics ; adsorption ; cellulose ; polyamideamine ; exponential kinetic equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The kinetic dependences have been investigated of the adsorption process of polyamideamine on monocarboxyl cellulose, bleached sulphate cellulose pulp of softwood and bleached sulphite cellulose pulp of hardwood. It has been found that the process kinetics can be described by means of the Elovich-Tyomkin exponential kinetic equation; the influence of the entropy factors plays a decisive role in changing the process speed; the activation energy is of the order of 6.5–8.0 kJ/mol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01422853
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  • 3
    Electronic Resource
    Electronic Resource
    Complex formation of Al2(SO4)3 in water-formamide mixtures (1985)
    Springer
    Journal of solution chemistry 14 (1985), S. 881-890 
    Details
    ISSN: 1572-8927
    Keywords: Kinetics ; formamide-water mixtures ; AlSO4 +
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The kinetics of formation of AlSO 4 + has been investigated in mixtures of water and formamide. In contrast to similar measurements with BeSO4, the substitution of solvating formamide molecules by the sulfate ion cannot be observed on the aluminum cation. On the other hand, with Al3+ cations three well separated water substitution processes are observed, as compared to a single one only with Be2+. An explanation for this behavior and for the different pH dependence of the sulfate complex formation for Al3+ and Be2+ cations is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00646297
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  • 4
    Electronic Resource
    Electronic Resource
    The kinetics of the dissolution of monoclinic pyrrhotite in aqueous acidic solutions (1982)
    Springer
    Monatshefte für Chemie 113 (1982), S. 1087-1092 
    Details
    ISSN: 1434-4475
    Keywords: Dissolution ; Kinetics ; Pyrrhotite ; Rotating disc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Auflösungsgeschwindigkeit von natürlichem monoklinen Pyrrhotin, FeS1.14, wurde in sauerstofffreien LösungenS([H+]=0.1, [Na+]=0.9, [ClO 4 − ]=1.0 mol kg−1) mit Hilfe der Methode der rotierenden Scheibe bestimmt. Im Temperaturbereich von 40–90° erfolgt die Auflösungsreaktion kinetisch kontrolliert, wobei eine Aktivierungsenergie von 14±1 kcal mol−1 (59±5 kJ mol−1) gefunden wurde.
    Notes: Abstract Using the rotating disc method, the rates of dissolution of natural monoclinic pyrrhotite, FeS1.14, in oxygen-free aqueous solutionsS([H+]=0.1, [Na+]=0.9, [ClO 4 − ]=1.0 mol kg−1) were determined. In the temperature range 40–90 °C the dissolution reaction occurs under kinetic control; the activation energy being 14±1 kcal mol−1 (50±5 kJ mol−1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00808622
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  • 5
    Electronic Resource
    Electronic Resource
    Kinetics and mechanism of oxidation of allyl alcohol byN-bromosuccinimide (1982)
    Springer
    Monatshefte für Chemie 113 (1982), S. 1239-1244 
    Details
    ISSN: 1434-4475
    Keywords: Allyl alcohol ; Kinetics ; Mechanism ; Oxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Kinetik der Oxidation von Allylalkohol mitN-Bromsuccinimid (NBS) wurde bei 35 °C in wäßrigem Medium untersucht. Die Reaktion zeigt erste Ordnung gegenüberNBS und Allylalkohol. Bei relativ hoher Säurekonzentration zeigt sich keine Änderung der Reaktionsgeschwindigkeit, bei niedriger Säurekonzentration wird die Reaktionsgeschwindigkeit beträchtlich erhöht. Es wurde kein primärer Salzeffekt festgestellt. Bei varriierender Quecksilberacetatkonzentration bleibt die Reaktionsgeschwindigkeit gleich, bei Abwesenheit von Quecksilberacetat wird jedoch die Geschwindigkeitskonstante erhöht. Die kinetischen Parameter,E a, derArrheniusfaktorA, ΔH ≠, ΔG ≠ und ΔS ≠ wurden bestimmt. Ein Geschwindigkeitsgesetz in Übereinstimmung mit den experimentellen Befunden wurde abgeleitet und ein Mechanismus vorgeschlagen.
    Notes: Abstract The kinetics of oxidation of allyl alcohol byN-bromosuccinimide (NBS) has been studied at 35 °C in aqueous medium. The reaction shows first order dependence on bothNBS and allyl alcohol. In fairly high acid concentration, there is no change in the rate of the reaction but at low acid concentration, the rate is considerably enhanced. There is no primary salt effect. At varying mercuric acetate concentrations, the rate constant remains the same. But in the absence of mercuric acetate, the rate is enhanced. The kinetic parameters,E a,Arrhenius factorA, ΔH≠, ΔG≠ and ΔS≠ have been calculated. A rate law in agreement with experimental results has been derived. A mechanism is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00808738
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  • 6
    Electronic Resource
    Electronic Resource
    Kinetik der Diazotierung des α-Naphthylamins in wäßriger Chlorwasserstofflösung, 2. Mitt. (1982)
    Springer
    Monatshefte für Chemie 113 (1982), S. 887-893 
    Details
    ISSN: 1434-4475
    Keywords: Diazotation ; Kinetics ; α-Naphthylamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Optimal diazotation conditions were determined by means of extinction measurements at various experimental conditions. The optimal conditions found arep H=9,5, the amount of phenol is 1 250 times the amount of α-naphthylamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799229
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  • 7
    Electronic Resource
    Electronic Resource
    The reduction of thoria with graphite (1982)
    Springer
    Monatshefte für Chemie 113 (1982), S. 3-14 
    Details
    ISSN: 1434-4475
    Keywords: Graphite ; Kinetics ; Reduction ; Thoria ; Thoriumcarbide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Reduktion von Thoriumoxid mit Graphit im Überschuß wurde mittels einer Thermowaage zwischen 1620 und 1920 K im Vakuum untersucht. Ab ThO2:C=1:50 war die Reaktionsgeschwindigkeit vom Mischungsverhältnis unabhängig; das Endprodukt war immer ThC2. Der logarithmische Gewichtsverlust war direkt proportional der Zeit, und dieArrheniusgerade zeigte einen Knickpunkt bei 1710 K: unterhalb dieser Temperatur ergab sich eine Aktivierungsenergie von 440 kJ, oberhalb eine solche von 260 kJ. Die Temperatur des Knickpunkts entspricht der Umwandlungstemperatur von monoklinem in tetragonal raumzentriertes ThC2.
    Notes: Abstract The reduction of thoria with excess graphite was studied with a thermo-balance in vacuum between 1620 and 1920 K. From Th02:C=1:50 the rate of reaction was independent of the ratio of the reactants; the endproduct was always ThC2. The logarithmic weight loss was directly proportional to the time, and theArrhenius plot showed a break at 1710 K: below this temperature the activation energy was found to be 440 kJ, above 260 kJ. The temperature corresponding to the break coincides with the transition temperature of monoclinic to body-centered tetragonal ThC2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00814331
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  • 8
    Electronic Resource
    Electronic Resource
    Kinetik und Mechanismus des Ligandentausches zwischen Thallium(III)oxinat und Eisen(III) in Propylencarbonat (1982)
    Springer
    Monatshefte für Chemie 113 (1982), S. 1093-1105 
    Details
    ISSN: 1434-4475
    Keywords: Kinetics ; Ligand-transfer ; Thallium (III)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The transfer of oxinate ions from thallium (III)oxinate to trivalent Fe(DMF) 6 3+ in propylenecarbonate takes place via rearrangements within a rapidly formed binuclear thallium(III)—iron(III) complex. In a last rapid step this rearranged complex reacts with excess reactants to the final products whose composition accordingly depends on the ratio of the reactant concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00808623
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  • 9
    Electronic Resource
    Electronic Resource
    Kinetics of the Ru(III) catalyzed oxidation of formaldehyde and acetaldehyde by alkaline hexacyanoferrate(III) (1985)
    Springer
    Monatshefte für Chemie 116 (1985), S. 729-736 
    Details
    ISSN: 1434-4475
    Keywords: Kinetics ; Mechanism ; Oxidation ; Ru(III) catalyzed
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Untersuchung der Kinetik erfolgte spektrophotometrisch. Die Geschwindigkeitskonstante der Oxidation von Formaldehyd ist direkt proportional zu [Fe(CN) 3− 6 ], währenddessen die entsprechende Konstante für Acetaldehyd proportional zuk[Fe(CN) 3− 6 ]/{k′ +k″[Fe(CN) 3− 6 ]} ist, wobeik,k′ undk″ Geschwindigkeitskonstanten sind. Die Reaktionsordnung für Acetaldehyd ist eine erste, die für Formaldehyd fällt von erster bis zu nullter Ordnung. Die Geschwindigkeitskonstante ist in jedem Fall proportional zu [Ru(III)] T . Es wird ein passender Mechanismus vorgeschlagen.
    Notes: Abstract The kinetics of ruthenium(III) catalyzed oxidation of formaldehyde and acetaldehyde by alkaline hexacyanoferrate(III) has been studied spectrophotometrically. The rate of oxidation of formaldehyde is directly proportional to [Fe(CN) 3− 6 ] while that of acetaldehyde is proportional tok[Fe(CN) 3− 6 ]/{k′ +k″[Fe(CN) 3− 6 ]}, wherek, k′ andk″ are rate constants. The order of reaction in acetylaldehyde is unity while that in formaldehyde falls from 1 to 0. The rate of reaction is proportional to [Ru(III)] T in each case. A suitable mechanism is proposed and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00809151
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of heavy-metal additions on ammonification and nitrification in soils contaminated with cadmium, lead and zinc (1982)
    Springer
    Plant and soil 69 (1982), S. 239-258 
    Details
    ISSN: 1573-5036
    Keywords: Ammonification ; Cadmium ; Heavy metals ; Kinetics ; Lead ; Nitrification ; Perfusion incubations ; Polluted soils ; Selection ; Toxicity ; Zinc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The sensitivity of the mineralization of nitrogen by a range of soils contaminated with heavy metals (up to 340 μg Cd g−1, 7500 μg Pb g−1 and 34000 μg Zn g−1) to the addition of heavy metals in solution were studied using pot incubations (ammonification) and a soil perfusion technique (nitrification). The ammonification of peptone showed little correlation between treatments with Cd, Zn (1000 and 5000 μg g−1) and Pb (10000 and 20000 μg g−1) and origin of the soil. Nitrification was considerably more sensitive to heavy metals than ammonification. All the soils had active, often large, populations of ammonifying and nitrifying organisms which showed substantial similarities between the soils. The rate of nitrifying activity (NO3−N production) was logrithmic in most cases. The presence of tolerant populations of nitrifying organisms in the contaminated soils was demonstrated. Tolerance was also eventually acquired after a longer lag phase, by the non-contaminated soil populations although the rate of activity was often reduced. Metals added in solution were adsorbed by the soil within 4 hours. Differences in toxicity between metal salts (chlorides, sulphates and acetate) were attributed to the amount left in solution. However, in many instances, acetate was found to stimulate all the stages in the mineralisation of nitrogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02374519
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  • 11
    Electronic Resource
    Electronic Resource
    Net mineralization and nitrification rates in a clay soil measured and predicted in permanent grassland from soil temperature and moisture content (1985)
    Springer
    Plant and soil 86 (1985), S. 151-172 
    Details
    ISSN: 1573-5036
    Keywords: Ammonification ; Clay soil ; Exchangeable ammonium ; Grassland ; Incubation ; Kinetics ; Nitrate ; Nitrification ; N cycle ; N mineralization ; Soil Moisture ; Soil temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Net mineralization of N and net nitrification in field-moist clay soils (Evesham-Kingston series) from arable and grassland sites were measured in laboratory incubation experiments at 4, 10 and 20°C. Three depth fractions to 30 cm were used. Nitrate accumulated at all temperatures except when the soil was very dry (θ=0.13 cm3 cm−3). Exchangeable NH4-ions declined during the first 24 h and thereafter remained low. Net mineralization and net nitrification approximated to zero-order reactions after 24 h, with Q10 values generally 〈1.6. The effect of temperature on both processes was linear although some results conformed to an Arrhenius-type relationship. The dependence of net mineralization and net nitrification in the field soil on soil temperature (10 cm depth) and moisture (0–15, 15–25, 25–35 cm depths) was modelled using the laboratory incubation data. An annual net mineralization of 350 kg N ha−1 and net nitrification of 346 kg N ha−1 were predicted between September 1980 and August 1981. The model probably overstressed the effect of soil moisture relative to soil temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02182891
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  • 12
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    Measurement of intracellular free calcium in monkey kidney cells with aequorin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-16
    Description: A method has been developed for the measurement of intracellular free calcium in mammalian cells. The calcium-sensitive photoprotein aequorin can be incorporated into isolated cells by hypo-osmotic treatment without altering the cell viability, permeability, or metabolism. Intracellular calcium activity (Cai2+) was monitored in a perfusion system. In monkey kidney cells (LLC-MK2), Cai2+ is approximately 57 nanomoles per liter. Changes in Cai2+ with time can also be followed: exposure of the cells to anaerobiosis or the calcium ionophore A23187 reversibly increases Cai2+. The method has also been successfully tested in rat hepatocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borle, A B -- Snowdowne, K W -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):252-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806904" target="_blank"〉PubMed〈/a〉
    Keywords: *Aequorin ; Anaerobiosis ; Animals ; Calcimycin/pharmacology ; Calcium/*metabolism ; Cell Line ; Kidney/drug effects/*metabolism ; Kinetics ; *Luminescent Proteins ; Macaca mulatta
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 13
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    Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-11
    Description: Receptors that selectively bind micromolar concentrations of benzodiazepines are present in rat brain membrane. These micromolar receptors exhibit saturable, stereospecific binding, and the potency of benzodiazepine binding to these receptors is correlated with the ability of the benzodiazepines to inhibit maximum electric shock-induced convulsions. Benzodiazepine receptors with nanomolar affinity differ from the micromolar receptors in their binding, kinetic, and pharmacologic characteristics. The micromolar receptors also bind phenytoin, a non-benzodiazepine anticonvulsant. These results provide evidence for a distinct class of clinically relevant benzodiazepine receptors that may regulate neuronal excitability and anticonvulsant activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowling, A C -- DeLorenzo, R J -- NS 1352/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1247-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281893" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism/pharmacology ; Benzodiazepinones/metabolism ; Brain/*metabolism ; Calmodulin/antagonists & inhibitors ; Diazepam/metabolism ; Kinetics ; Ligands ; Protein Kinase Inhibitors ; Rats ; Receptors, Drug/*metabolism ; Receptors, GABA-A ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 14
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    Artificial enzymes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-05
    Description: Simple chemical catalysts have been designed to achieve some desirable features of enzymes. These novel catalysts are not proteins, but they may incorporate the typical enzyme catalytic groups and they achieve selectivity in their reactions by use of geometric control, as do enzymes. Catalysts that carry out geometrically controlled chlorinations of aromatic rings and steroids have been constructed. Other catalysts achieve the selective synthesis of amino acids, and still others imitate ribonuclease in detailed mechanism and hydrolyze RNA. Optimization of geometries has led to a rate acceleration of over 10(8) in one instance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, R -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):532-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123255" target="_blank"〉PubMed〈/a〉
    Keywords: Catalysis ; Cyclodextrins ; *Enzymes ; Kinetics ; Models, Chemical ; Ribonucleases ; Structure-Activity Relationship ; Substrate Specificity ; Transaminases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 15
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    Long-term synaptic potentiation in the superior cervical ganglion (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-12
    Description: Brief tetanic stimulation of the preganglionic nerves to the superior cervical ganglion enhances the postganglionic response to single preganglionic stimuli for 1 to 3 hours. This long-term potentiation of transmission through the ganglion is apparently not attributable to a persistent muscarinic action of the preganglionic neurotransmitter, acetylcholine, since neither the magnitude nor the time course of the phenomenon is reduced by atropine. The decay of long-term potentiation can be described by a first-order kinetic process with a mean time constant of 80 minutes. We conclude that long-term potentiation, once considered a unique property of the hippocampus, is in fact a more general feature of synaptic function. This form of synaptic memory may significantly influence information processing and control in other regions of the nervous system, including autonomic ganglia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, T H -- McAfee, D A -- 12116/PHS HHS/ -- NS 16576/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 12;215(4538):1411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ganglia, Sympathetic/*physiology ; Kinetics ; Learning/*physiology ; Neuronal Plasticity ; Rats ; Synapses/*physiology ; *Synaptic Transmission ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Evidence that glucose "marks" beta cells resulting in preferential release of newly synthesized insulin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Studies of isolated islets labeled with radioactive leucine show that glucose at a critical time "marks" islets in such a way as to cause preferential release of newly synthesized insulin. The preferential release of insulin from marked islets is relatively independent of subsequent secretagogues or rates of insulin secretion. Previous kinetic studies have indicated that the critical time at which marking occurs is after proinsulin biosynthesis but before the secretory event. Thus, secretory cells may regulate the diversion of newly synthesized material for immediate release as it is approaching or transiting the Golgi apparatus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, G -- Gishizky, M L -- Grodsky, G M -- AM 01410/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):56-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6181562" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-3-isobutylxanthine/pharmacology ; Animals ; Glucose/*pharmacology ; In Vitro Techniques ; Insulin/biosynthesis/*secretion ; Islets of Langerhans/drug effects/*secretion ; Kinetics ; Leucine ; Potassium/pharmacology ; Tolbutamide/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Modulation of striatal dopaminergic function by local injection of 5'-N-ethylcarboxamide adenosine (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Rats rotated to the left when 5'-N-ethylcarboxamide adenosine (NECA) was injected into the left caudate nucleus and apomorphine was administered subcutaneously. The combination of NECA and apomorphine was more potent than L-(phenylisopropyl)adenosine and apomorphine in eliciting rotation, suggesting the involvement of adenosine receptors of the Ra type. The response was reduced when 2',5'-dideoxyadenosine was injected along with NECA into the caudate nucleus or when theorphylline was given intraperitoneally. Higher doses of apomorphine elicited a self-mutilatory response after the injection of NECA into the caudate nucleus. These results suggest that adenosine may be involved in the modulation of dopaminergic function in the striatum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, R D -- Proudfit, H K -- Yeung, S M -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):58-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123218" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/administration & dosage/*analogs & derivatives/pharmacology ; Adenosine-5'-(N-ethylcarboxamide) ; Animals ; Apomorphine/pharmacology ; Caudate Nucleus/*physiology ; Corpus Striatum/*physiology ; Dopamine/*physiology ; Injections ; Kinetics ; Male ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Rotation ; Vasodilator Agents/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Preferential attack of mitochondrial DNA by aflatoxin B1 during hepatocarcinogenesis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: Administration of the hepatic carcinogen aflatoxin B1 to experimental animals results in covalent binding to liver mitochondrial DNA at concentrations three to four times higher than nuclear DNA. The concentration of carcinogen adducts in mitochondrial DNA remains unchanged even after 24 hours, possible because of lack of excision repair. Similarly, mitochondrial transcription and translation remain inhibited up to 24 hours suggesting long-term effects of aflatoxin B1 on the mitochondrial genetic system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niranjan, B G -- Bhat, N K -- Avadhani, N G -- CA-22762/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):73-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6797067" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxin B1 ; Aflatoxins/*metabolism ; Animals ; DNA, Mitochondrial/*metabolism ; Kinetics ; Liver Neoplasms/*chemically induced/metabolism ; Male ; Mitochondria, Liver/*metabolism ; Neoplasms, Experimental/chemically induced ; Protein Biosynthesis/drug effects ; Rats ; Transcription, Genetic/drug effects
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  • 19
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    Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nieto-Sampedro, M -- Lewis, E R -- Cotman, C W -- Manthorpe, M -- Skaper, S D -- Barbin, G -- Longo, F M -- Varon, S -- AG-00538/AG/NIA NIH HHS/ -- MH-19691/MH/NIMH NIH HHS/ -- NS-16349/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):860-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100931" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/physiology ; Animals ; Brain/*physiology ; Brain Injuries/*physiopathology ; Cell Survival/drug effects ; Cells, Cultured ; Cholinergic Fibers/physiology ; Kinetics ; Nerve Growth Factors/*metabolism/pharmacology ; *Nerve Regeneration ; Rats ; Rats, Inbred Strains ; Wound Healing
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  • 20
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    Norethisterone, a major ingredient of contraceptive pills, is a suicide inhibitor of estrogen biosynthesis (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-05
    Description: Norethisterone (17 alpha-ethynyl-19-nortestosterone) is an effective irreversible inhibitor of estrogen synthetase (aromatase), the enzyme responsible for the conversion of androgens to estrogens, even at a 2 X 10(-6) molar concentration. This irreversible inactivation, which is directed toward the active site of aromatase and requires the cofactor-reduced nicotinamide adenine dinucleotide phosphate, is both time- and concentration-dependent. Ethisterone (17 alpha-ethynyltestosterone), in contrast, is not a suicide inhibitor of aromatase even at concentrations of 10(-4) molar.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Osawa, Y -- Yarborough, C -- HDO4945/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1249-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058343" target="_blank"〉PubMed〈/a〉
    Keywords: *Aromatase Inhibitors ; Binding Sites/drug effects ; Contraceptives, Oral/*pharmacology ; Estrogens/*biosynthesis ; Female ; Humans ; Kinetics ; Microsomes/enzymology ; Norethindrone/*pharmacology ; Oxidoreductases/*antagonists & inhibitors ; Placenta/enzymology ; Pregnancy
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  • 21
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    Translational efficiency of transfer RNA's: uses of an extended anticodon (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-11-12
    Description: Transfer RNA's are probably very strongly selected for translational efficiency. In this article, the argument is presented that the coding performance of the triplet anticodon is enhanced by selection of a matching anticodon loop and stem sequence. the anticodon plus these nearby sequence features (the extended anticodon) therefore contains more coding information than the anticodon alone and can perform more efficiently and accurately at the ribosome. This idea successfully accounts for the relative efficiencies of many transfer RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yarus, M -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):646-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6753149" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Escherichia coli/genetics ; Kinetics ; Nucleic Acid Conformation ; *Protein Biosynthesis ; RNA, Transfer/*genetics ; Ribosomes/metabolism ; Structure-Activity Relationship ; Suppression, Genetic
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  • 22
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    Proton nuclear magnetic resonance of intact Friend leukemia cells: phosphorylcholine increase during differentiation (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: Proton nuclear magnetic resonance of intact Friend leukemia cells was used to analyze their erythroid-like differentiation. The technique, which requires only 10(3) to 10(9) cells and approximately 2 minutes for acquisition of each spectrum, demonstrated the occurrence of many signal changes during differentiation. With cell extracts, 64 signals were assigned to 12 amino acids and 19 other intermediary metabolites, and a dramatic signal change was attributed to a fourfold increase in cytoplasmic phosphorylcholines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agris, P F -- Campbell, I D -- 1-F33-GM07826/GM/NIGMS NIH HHS/ -- 1-FOG-TW00440/TW/FIC NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1325-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079765" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Choline/*analogs & derivatives ; Kinetics ; Leukemia, Experimental/*physiopathology ; Magnetic Resonance Spectroscopy ; Mice ; Phosphorylcholine/*analysis
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  • 23
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    Molecular biology of the sea urchin embryo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Research on the early development of the sea urchin offers new insights into the process of embryogenesis. Maternal messenger RNA stored in the unfertilized egg supports most of the protein synthesis in the early embryo, but the structure of maternal transcripts suggests that additional functions are also possible. The overall developmental patterns of transcription and protein synthesis are known, and current measurements describe the expression of specific genes, including the histone genes, the ribosomal genes, and the actin genes. Possible mechanisms of developmental commitment are explored for regions of the early embryo that give rise to specified cell lineages, such as the micromere-mesenchyme cell lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davidson, E H -- Hough-Evans, B R -- Britten, R J -- GM20927/GM/NIGMS NIH HHS/ -- HD05753/HD/NICHD NIH HHS/ -- RR00986/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):17-26.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178156" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/genetics ; Animals ; Base Sequence ; Blastocyst/physiology ; Embryo, Nonmammalian/*physiology ; Female ; Fertilization ; Gastrula/physiology ; Histones/genetics ; Kinetics ; Larva/physiology ; Polyribosomes/metabolism ; RNA/genetics ; RNA, Messenger/genetics ; Ribosomal Proteins/genetics ; Sea Urchins/*physiology ; Transcription, Genetic
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  • 24
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    Multiplication of tobacco mosaic virus in tobacco leaf disks is inhibited by (2'-5) oligoadenylate (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-25
    Description: The oligonucleotide (2'-5') oligoadenylate that is induced in interferon-treated animal cells protects plant tissue from infection by the tobacco mosaic virus. This inhibition of virus multiplication was obtained at concentrations comparable to those affecting protein synthesis and antiviral activities in animal cells. After treatment with (2'-5') oligoadenylate, the multiplicability of tobacco mosaic virus was reduced by 80 to 90 percent as measured by enzyme-linked immunosorbent assay. These results, along with the observation that human interferon protects tobacco tissue from infection by tobacco mosaic virus, indicate that plants and animals may have a common pathway for virus resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Devash, Y -- Biggs, S -- Sela, I -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1415-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178155" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/*pharmacology ; Animals ; Cells, Cultured ; Interferons/pharmacology ; Kinetics ; Oligonucleotides/*pharmacology ; Oligoribonucleotides/*pharmacology ; Plants, Toxic ; Tobacco/microbiology ; Tobacco Mosaic Virus/*drug effects ; Virus Replication/drug effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    Cystine transport is defective in isolated leukocyte lysosomes from patients with cystinosis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-24
    Description: The activity of a cystine transport system in lysosomes prepared from the leukocytes of patients with cystinosis was found to be deficient. In normal subjects, this system was resistant to N-ethylmaleimide and demonstrated saturation kinetics. Lysosomes from individuals heterozygous for cystinosis demonstrated a reduced maximum velocity for cystine egress from lysosomes. The rate of cystine escape from normal lysosomes was enhanced by adenosine triphosphate. The availability of normal and mutant lysosomes provides a means of investigating mechanisms of amino acid transport across lysosomal membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gahl, W A -- Bashan, N -- Tietze, F -- Bernardini, I -- Schulman, J D -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1263-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112129" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport/drug effects ; Carrier Proteins/metabolism ; Cysteine/metabolism ; Cystine/*metabolism ; Cystinosis/*metabolism ; Ethylmaleimide/pharmacology ; Humans ; Kinetics ; Leukocytes/*metabolism ; Lysosomes/metabolism
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  • 26
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    Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-17
    Description: The biosynthesis of melanin is initiated by the catalytic oxidation of tyrosine to dopa by tyrosinase in a reaction that requires dopa as a cofactor. Tyrosine then catalyzes the dehydrogenation of dopa to dopaquinone. The subsequent reactions can proceed spontaneously in vitro. Tyrosinase, purified from murine melanomas and the skins of brown mice, has now been shown to catalyze a third reaction in mammalian melanogenesis, namely the conversion of 5,6-dihydroxyindile to melanochrome. This reaction requires dopa as a cofactor and is inhibited by tyrosine. Conversely, 5,6-dihydroxyindole inhibits the oxidation of tyrosine to dopa, so that the relative concentrations of tyrosine and 5,6-dihydroxyindole within the mammalian pigment cell are capable of regulating melanogenesis in a previously unrecognized fashion. Tyrosinase has the unusual property of catalyzing three distinct reactions within a single biochemical pathway: the hydroxylation of a monophenol, the dehydrogenation of a catechol, and the dehydrogenation of a dihydroxyindole. The first and third of these reactions require dopa as a cofactor; in the second reaction, dopa is a substrate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korner, A -- Pawelek, J -- DA-01147/DA/NIDA NIH HHS/ -- DA-05186/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1163-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810464" target="_blank"〉PubMed〈/a〉
    Keywords: Catechol Oxidase/*metabolism ; Cells, Cultured ; Dihydroxyphenylalanine/metabolism ; Indoles/metabolism ; Kinetics ; Melanins/*biosynthesis ; Melanoma/enzymology ; Monophenol Monooxygenase/*metabolism ; Neoplasms, Experimental/enzymology ; Substrate Specificity ; Tyrosine/metabolism
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  • 27
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    Amplification and adaptation in regulatory and sensory systems (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- Goldbeter, A -- Stock, J B -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):220-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089556" target="_blank"〉PubMed〈/a〉
    Keywords: *Acclimatization ; *Adaptation, Physiological ; Animals ; Environment ; Kinetics ; Mathematics ; Models, Biological ; Models, Neurological ; Sense Organs/*physiology ; Sensory Receptor Cells/physiology
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  • 28
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    Differential breakdown of phylogenetically diverse ribosomal RNA's inserted via liposomes into mammalian cells (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Liposomes were used to deliver ribosomal RNA's from the different organisms into cultivated mouse plasmacytoma cells. Ribosomal RNA from Escherichia coli was degraded intracellularly within 1 hour, whereas mouse and yeast ribosomal RNA's were degraded more slowly. This indicates that cells can discriminated between different ribosomal RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavelle, D -- Ostro, M J -- Giacomoni, D -- GM 27935/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178157" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Escherichia coli ; Kinetics ; *Liposomes ; Mice ; Molecular Weight ; Neoplasms, Experimental/metabolism ; Plasmacytoma/*metabolism ; RNA, Bacterial/metabolism ; RNA, Ribosomal/*metabolism ; Saccharomyces cerevisiae ; Species Specificity
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  • 29
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    Pituitary receptor site blockade by a gonadotropin-releasing hormone antagonist in vivo: mechanism of action (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-23
    Description: Administration of a potent gonadotropin-releasing hormone (GnRH) antagonist [Nac-L-Ala1,pCl-D-Phe2,D-Trp3,6]GnRH as a single subcutaneous injection to castrated adult male rats reduced, by more than 90 percent, both serum luteinizing hormone concentrations and specific pituitary GnRH receptor binding. This effect persisted for 24 hours. The dissociation rate of the antagonist from pituitary membrane homogenates was fourfold slower than the dissociation rate of a potent agonist. The prolonged in vivo inhibition of pituitary GnRH receptor binding and luteinizing hormone secretion by the GnRH antagonist may be mediated by the slower dissociation rate of the antagonist from its specific pituitary membrane receptor site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heber, D -- Dodson, R -- Swerdloff, R S -- Channabasavaiah, K -- Stewart, J M -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):420-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280278" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Follicle Stimulating Hormone/secretion ; Gonadotropin-Releasing Hormone/*antagonists & inhibitors ; Kinetics ; Luteinizing Hormone/*secretion ; Male ; Pituitary Gland/*metabolism ; Rats ; Receptors, Cell Surface/*drug effects/metabolism ; Receptors, LHRH
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  • 30
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    Rat pro-opiomelanocortin contains sulfate (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Intermediate lobes isolated from rat pituitary glands incorporated [35S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products. Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoshina, H -- Hortin, G -- Boime, I -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):63-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6283633" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*biosynthesis ; Amino Acid Sequence ; Animals ; In Vitro Techniques ; Kinetics ; Leucine ; Pituitary Gland/*metabolism ; Pituitary Hormones, Anterior/*biosynthesis ; Pro-Opiomelanocortin ; Protein Precursors/*biosynthesis ; Radioisotope Dilution Technique ; Rats ; Sulfur Radioisotopes ; Sulfuric Acids/*metabolism ; Tritium
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  • 31
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    Hydrolysis of nerve gas by squid-type diisopropyl phosphorofluoridate hydrolyzing enzyme on agarose resin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-05
    Description: An enzyme purified from squid nerve that hydrolyzes the cholinesterase inhibitor diisopropyl phosphorofluoridate (DFP) has now been coupled to agarose beads. A column of this agarose-DFPase hydrolyzes the nerve gas 1,2,2-trimethylpropyl methylphosphonofluoridate (Soman). Although the more inhibitory of the four diastereoisomers of Soman are hydrolyzed least rapidly, a column of sufficient length will accomplish 95 percent hydrolysis whether measured by fluoride release or loss of cholinesterase-inhibiting power. The results suggest a means for detoxifying unwanted chemical warfare agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoskin, F C -- Roush, A H -- ES-02116/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1255-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058344" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Decapodiformes/*enzymology ; Enzymes, Immobilized ; Isoflurophate/*metabolism ; Kinetics ; Molecular Weight ; Organophosphorus Compounds/*metabolism ; Soman/*metabolism ; Stereoisomerism ; Substrate Specificity
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  • 32
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    Colloidal solution of water in organic solvents: a microheterogeneous medium for enzymatic reactions (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-11-26
    Description: To simulate in vitro the conditions under which enzymes act in vivo, enzyme molecules have been entrapped in hydrated reverse micelles of a surfactant in organic solvents. In this system the catalytic activity of one of the enzymes studied (peroxidase) became much higher than in water, and the specificity of the other enzyme (alcohol dehydrogenase) was dramatically altered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinek, K -- Levashov, A V -- Khmelnitsky, Y L -- Klyachko, N L -- Berezin, I V -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6753152" target="_blank"〉PubMed〈/a〉
    Keywords: Alcohol Oxidoreductases/metabolism ; *Catalysis ; Enzymes/*metabolism ; Kinetics ; Micelles ; Peroxidases/metabolism ; Solvents ; *Water
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  • 33
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    Light-induced modification of Drosophila retinal polypeptides in vivo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: The effect of light on the polypeptide map profile of the Drosophila eye preparation was examined by two-dimensional polyacrylamide gel electrophoresis. The results show (i) that illuminating the living fly reversibly changes the isoelectric points of three classes of polypeptides specific for the photoreceptor layer and (ii) that the norpA mutation, which prevents the generation of the receptor potential, blocks the modifications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsumoto, H -- O'Tousa, J E -- Pak, W L -- EY 00033/EY/NEI NIH HHS/ -- EY 07008/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):839-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100927" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila/*metabolism ; Electrophoresis, Polyacrylamide Gel ; Eye Proteins/*metabolism ; Isoelectric Point ; Kinetics ; *Light ; Mutation ; Peptides/*metabolism ; Photoreceptor Cells/metabolism ; Retina/*metabolism
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  • 34
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    High-affinity choline transport in proteoliposomes derived from rat cortical synaptosomes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: Functional high- and low-affinity choline transport processes from rat cortical plasma membranes were reconstituted in phosphatidylcholine bilayer liposomes. The high-affinity choline transporter demonstrated a pharmacological profile and ion dependency that were identical to those of intact synaptosomes. This preparation may be used to further characterize choline transport and, with appropriate supplementation, to investigate the release of acetylcholine in the absence of synaptic vesicles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer, E M -- Cooper, J R -- NS 09836/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):843-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100928" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Animals ; Biological Transport ; Cell Membrane/metabolism ; Chlorides/metabolism ; Choline/*metabolism ; Kinetics ; Lipid Bilayers/metabolism ; Liposomes/*metabolism ; Phosphatidylcholines/metabolism ; Rats ; Sodium/metabolism ; Synaptosomes/*metabolism
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    Cysteamine: a potent and specific depletor of pituitary prolactin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morphology, as determined by electron microscopy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millard, W J -- Sagar, S M -- Landis, D M -- Martin, J B -- AM 26252/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):452-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089575" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Cysteamine/*pharmacology ; Domperidone/pharmacology ; Dose-Response Relationship, Drug ; Kinetics ; Male ; Pituitary Gland, Anterior/*metabolism ; Prolactin/analysis/*metabolism/secretion ; Rats ; Receptors, Dopamine/physiology ; Spiperone/pharmacology
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    Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-08
    Description: Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morphis, L -- Constantopoulos, A -- Matsaniotis, N -- Papaphilis, A -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):156-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123226" target="_blank"〉PubMed〈/a〉
    Keywords: Aminophylline/pharmacology ; Animals ; Animals, Newborn ; Bilirubin/metabolism/*pharmacology ; Brain/drug effects/*metabolism ; Kinetics ; Nerve Tissue Proteins/*metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Rabbits
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    Insulin stimulation of nucleoside triphosphatase activity in isolated nuclear envelopes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-28
    Description: The activity of nucleoside triphosphatase, an enzyme that regulates nuclear messenger RNA transport, was measured in highly purified nuclear envelopes isolated from rat liver. Addition of picomolar concentrations of insulin to freshly prepared nuclear envelopes directly increased the enzyme activity. The major effect of insulin on this enzyme was to increase the maximum velocity of its activity; no significant effects were seen on the affinity constant. These studies raise the possibility, therefore, that the nuclear envelope is a site where insulin regulates nuclear functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Purrello, F -- Vigneri, R -- Clawson, G A -- Goldfine, I D -- AM 26667/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 May 28;216(4549):1005-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281885" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell-Free System ; Enzyme Activation/drug effects ; Insulin/*pharmacology ; Kinetics ; Liver/enzymology ; Nuclear Envelope/*enzymology ; Nucleoside-Triphosphatase ; Nucleotides/metabolism ; Phosphoric Monoester Hydrolases/*metabolism ; RNA, Messenger/metabolism ; Rats
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  • 38
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    Antidepressants alter cerebrovascular permeability and metabolic rate in primates (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-16
    Description: External detection of the annihilation radiation produced by water labeled with oxygen-15 was used to measure cerebrovascular permeability and cerebral blood flow in six rhesus monkeys. Use of oxygen-15 also permitted assessment of cerebral metabolic rate in two of the monkeys. Amitriptyline produced a dose-dependent, reversible increase in permeability at plasma drug concentrations which are therapeutic for depressed patients. At the same concentrations the drug also produced a 20 to 30 percent reduction in cerebral metabolic rate. At higher doses normal autoregulation of cerebral blood flow was suspended, but responsivity to arterial carbon dioxide was normal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Preskorn, S H -- Raichle, M E -- Hartman, B K -- HL-13851/HL/NHLBI NIH HHS/ -- NS-06833/NS/NINDS NIH HHS/ -- NS-17252/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):250-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089562" target="_blank"〉PubMed〈/a〉
    Keywords: Amitriptyline/*pharmacology ; Animals ; Blood Pressure/drug effects ; Blood-Brain Barrier/drug effects ; Brain/drug effects/*metabolism ; Capillaries/physiology ; Cerebrovascular Circulation/*drug effects ; Kinetics ; Macaca mulatta ; Permeability ; Regional Blood Flow/drug effects
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  • 39
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    Phosphorylation of myosin light chains in mouse fast-twitch muscle associated with reduced actomyosin turnover rate (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: Phosphorylation of the 18,000-dalton light chains of the fast-twitch myosin in mouse extensor digitorum longus muscles was correlated with reduction in the rate of the actomyosin adenosinetriphosphatase in vivo, but neither of these changes occurred in the soleus muscle. These results suggest that actomyosin interactions can be down-regulated by a reversible covalent modification of myosin light chains, that a mechanism for thick-filament regulation occurs in vertebrate skeletal muscle, and that the expression of this regulation may be limited to a specific fiber type.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crow, M T -- Kushmerick, M J -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):835-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6285472" target="_blank"〉PubMed〈/a〉
    Keywords: Actomyosin/metabolism ; Adenosine Triphosphatases/metabolism ; Animals ; Energy Metabolism ; Kinetics ; Mice ; Muscle Contraction ; Muscle, Smooth/metabolism ; Muscles/*metabolism ; Myosin-Light-Chain Phosphatase ; Myosins/*metabolism ; Phosphoprotein Phosphatases/metabolism ; Phosphorylation
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  • 40
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    H-2 histocompatibility region: influence on the murine glucocorticoid receptor and its response (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-28
    Description: The influence of the H-2 histocompatibility complex on glucocorticoid receptor levels, and the biochemical response of glucocorticoid action measured as the degree of inhibition of prostaglandin production, has been studied in the mouse thymus and lung. The B10A (H-2a) strain of mice has significantly higher glucocorticoid receptor levels and a significantly greater biochemical response to glucocorticoid than the B10 (H-2b) strain, which differs from B10A within the H-2 complex only. Thus, the anti-inflammatory hormone response of glucocorticoids is correlated to hormone receptor level, both of which are influenced by the H-2 locus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, C -- Goldman, A -- DE-0541/DE/NIDCR NIH HHS/ -- DE-4622/DE/NIDCR NIH HHS/ -- DE-5592/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1982 May 28;216(4549):994-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dexamethasone/metabolism/pharmacology ; Female ; Genetic Linkage ; H-2 Antigens/*genetics ; Kinetics ; Lung/metabolism ; *Major Histocompatibility Complex ; Male ; Mice ; Mice, Inbred Strains ; Prostaglandins/biosynthesis ; Receptors, Glucocorticoid/*genetics ; Receptors, Steroid/*genetics ; Thymus Gland/metabolism
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    In vivo activation of zoxazolamine metabolism by flavone (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-25
    Description: The metabolism of zoxazolamine to 6-hydroxyzoxazolamine by liver microsomes from neonatal rats is stimulated severalfold by the in vitro addition of flavone, a naturally occurring compound found in several plant species. The intraperitoneal injection of flavone into neonatal rats causes an immediate several-fold stimulation in the rate of total body metabolism of simultaneously administered zoxazolamine. This is the first demonstration of stimulation of oxidative drug metabolism in vivo by a zenobiotic that is an activator of hepatic microsomal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lasker, J M -- Huang M-T -- Conney, A H -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1419-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089530" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Cytochrome P-450 Enzyme System/metabolism ; Drug Combinations ; Drug Interactions ; Flavonoids/*pharmacology ; Hydroxylation ; Kinetics ; Microsomes, Liver/*metabolism ; Rats ; Zoxazolamine/*metabolism
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  • 42
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    Virus-induced corticosterone in hypophysectomized mice: a possible lymphoid adrenal axis (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-24
    Description: Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced the differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, E M -- Meyer, W J -- Blalock, J E -- AM30046/AM/NIADDK NIH HHS/ -- HL20201/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1311-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183748" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/*physiology ; Animals ; Corticosterone/*biosynthesis ; Dexamethasone/pharmacology ; *Hypophysectomy ; Interferons/biosynthesis ; Kinetics ; Lymph Nodes/*physiology ; Mice ; Newcastle Disease/*metabolism ; Time Factors
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    Experimental hepatic encephalopathy: changes in the binding of gamma-aminobutyric acid (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-23
    Description: Two populations of receptors for gamma-aminobutyric acid, one with low- and the other with high-affinity characteristics, are detectable in frozen, thawed, Triton-treated synaptic membrane preparations from normal brain. It is now reported that membrane preparations from rats with mild galactosamine-induced hepatic encephalopathy show an increase in the number of low- and high-affinity gamma-aminobutyric acid binding sites, whereas those from rats with severe encephalopathy show only high-affinity binding sites. Thus, hepatic encephalopathy appears to involve partial degeneration of the gamma-aminobutyric acid-containing presynaptic nerve terminals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baraldi, M -- Zeneroli, Z L -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280279" target="_blank"〉PubMed〈/a〉
    Keywords: Bicuculline/metabolism ; Binding, Competitive ; Brain/*metabolism ; Disease Models, Animal ; Galactosamine ; Hepatic Encephalopathy/*metabolism ; Humans ; Kinetics ; Receptors, Cell Surface/*metabolism ; Receptors, GABA-A ; Synaptic Membranes/metabolism ; Time Factors ; gamma-Aminobutyric Acid/*metabolism
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    DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnboim, H C -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1247-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6276978" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Survival/drug effects ; Cells, Cultured ; Cocarcinogenesis ; *Dna ; Free Radicals ; Humans ; Kinetics ; Leukocytes/*drug effects ; Oxygen Consumption/drug effects ; Phorbols/*pharmacology ; Superoxides/metabolism ; Tetradecanoylphorbol Acetate/*pharmacology
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  • 45
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    Endotoxin-stimulated opioid peptide secretion: two secretory pools and feedback control in vivo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of beta-endorphin to beta-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in beta-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carr, D B -- Bergland, R -- Hamilton, A -- Blume, H -- Kasting, N -- Arnold, M -- Martin, J B -- Rosenblatt, M -- AM 07028-06/AM/NIADDK NIH HHS/ -- AM 26252/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):845-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6285473" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/drug effects ; Endorphins/blood/cerebrospinal fluid/*secretion ; Endotoxins/*pharmacology ; Escherichia coli ; Feedback ; Kinetics ; Naloxone/pharmacology ; Peptide Fragments/blood/cerebrospinal fluid ; Sheep ; beta-Endorphin
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    Reproducing results (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kark, P -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089541" target="_blank"〉PubMed〈/a〉
    Keywords: *Ethics ; Friedreich Ataxia/enzymology ; Humans ; Kinetics ; *National Institutes of Health (U.S.) ; Pyruvate Dehydrogenase Complex/metabolism ; United States
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  • 47
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    Numbers of receptor sites from Scatchard graphs: facts and fantasies (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-24
    Description: Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites are generally not correct.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1247-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287580" target="_blank"〉PubMed〈/a〉
    Keywords: Kinetics ; Ligands/metabolism ; Receptors, Cell Surface/*metabolism ; Statistics as Topic/*methods
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  • 48
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    Corticotropin-releasing factor stimulates accumulation of adenosine 3', 5'-monophosphate in rat pituitary corticotrophs (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-28
    Description: The presence of synthetic ovine corticotropin-releasing factor leads to a rapid and marked stimulation of adenosine 3', 5'-monophosphate accumulation in an enriched population of rat pituitary corticotrophs in primary culture. The increase, observed as early as 60 seconds after the addition of corticotropin-releasing factor, suggests that changes in the intracellular concentration of the cyclic nucleotide coincide with or precede the secretion of adrenocorticotropic hormone in response to corticotropin-releasing factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Labrie, F -- Veilleux, R -- Lefevre, G -- Coy, D H -- Sueiras-Diaz, J -- Schally, A V -- New York, N.Y. -- Science. 1982 May 28;216(4549):1007-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281886" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*secretion ; Animals ; Corticotropin-Releasing Hormone/*pharmacology ; Cyclic AMP/*metabolism ; Female ; Kinetics ; Pituitary Gland, Anterior/*drug effects/*metabolism ; Rats
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  • 49
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    Are ions involved in the gating of calcium channels? (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-08
    Description: The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current activation, surface charge effects, or incomplete space clamping. The findings indicate participation of the divalent cations in the voltage-driven calcium channel gating process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saimi, Y -- Kung, C -- GM22714/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):153-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289432" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Barium/metabolism ; Calcium/*metabolism ; Cell Membrane/physiopathology ; Ion Channels/*metabolism ; Kinetics ; Membrane Potentials ; Paramecium/*physiology ; Strontium/metabolism
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  • 50
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    beta, gamma-Peroxy analogs of adenosine and guanosine triphosphate: synthesis and biological activity (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-01
    Description: Extended analogs of adenosine triphosphate (ATP) and guanosine triphosphate (GTP), in which a peroxide bridge replaces the terminal bridge-oxygen of the triphosphate chain, have been synthesized. The ability of beta, gamma-peroxy-ATP to inhibit or substitute for ATP in representative enzyme systems and that of beta, gamma-peroxy-GTP, for FTP in protein synthesis was tested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosendahl, M S -- Leonard, N J -- GM-05829/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):81-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053563" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/*analogs & derivatives/chemical synthesis/metabolism ; Guanosine Triphosphate/*analogs & derivatives/chemical synthesis/metabolism ; Kinetics ; Peroxides ; Protein Biosynthesis/drug effects ; Structure-Activity Relationship
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    Tritiated imipramine binding sites are decreased in the frontal cortex of suicides (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: Binding characteristics of tritiated imipramine were determined in the frontal cortex of suicides and well-matched controls. Maximal binding was significantly lower in brains from the suicides. This finding is consistent with reports of decreased tritiated imipramine binding in the platelets of patients diagnosed as having a major affective disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, M -- Virgilio, J -- Gershon, S -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1337-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079769" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Carrier Proteins ; Cerebral Cortex/*metabolism ; Humans ; Imipramine/*metabolism ; Kinetics ; Middle Aged ; Receptors, Drug/*metabolism ; Reference Values ; *Suicide ; Tritium
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    Biotin enhances guanylate cyclase activity (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: Biotin and its analog, (+)-biotin-p-nitrophenyl ester enhanced guanylate cyclase activity two- to threefold in rat liver, kidney, colon, cerebellum, and heart. Dose-response relationships revealed that at concentrations as low as 1 micromolar, both biotin and its analog caused maximal augmentation of guanylate cyclase activity. These data suggest a role for the activation of guanylate cyclase in the mechanism of action of this vitamin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vesely, D L -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6123152" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotin/analogs & derivatives/*pharmacology ; Cerebellum/enzymology ; Colon/enzymology ; Guanylate Cyclase/*metabolism ; Kidney/enzymology ; Kinetics ; Liver/enzymology ; Myocardium/enzymology ; Rats ; Rats, Inbred Strains
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    Induction of the intermediate pituitary by stress: synthesis and release of a nonopioid form of beta-endorphin (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-25
    Description: beta-Endorphin in the intermediate lobe of the pituitary gland is posttranslationally modified to produce opioid inactive peptides. Whether these are metabolites or biologically relevant products has not been known. It was found that repeated stress induces increased biosynthesis and release of beta-endorphin-like substances from the intermediate lobe of rats and that opioid-inactive N-acetylated beta-endorphin-(1-31) is selectively made and liberated. The possible role of this nonopioid product and the selective release of peptide forms are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Akil, H -- Shiomi, H -- Matthews, J -- New York, N.Y. -- Science. 1985 Jan 25;227(4685):424-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3155575" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatography, High Pressure Liquid ; Endorphins/*biosynthesis/blood ; Half-Life ; Kinetics ; Melanocyte-Stimulating Hormones/biosynthesis/blood ; Pituitary Gland/*metabolism ; Rats ; Stress, Physiological/*metabolism ; beta-Endorphin
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    The mechanisms of irreversible enzyme inactivation at 100C (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-14
    Description: The mechanism of irreversible thermoinactivation of an enzyme has been quantitatively elucidated in the pH range relevant to enzymatic catalysis. The processes causing irreversible inactivation of hen egg-white lysozyme at 100 degrees C are deamidation of asparagine residues, hydrolysis of peptide bonds at aspartic acid residues., destruction of disulfide bonds, and formation of incorrect (scrambled) structures; their relative contributions depend of the pH.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahern, T J -- Klibanov, A M -- New York, N.Y. -- Science. 1985 Jun 14;228(4705):1280-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001942" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Asparagine ; Chickens ; Disulfides ; Hot Temperature ; Hydrogen-Ion Concentration ; Kinetics ; *Muramidase ; *Protein Denaturation
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    Two distinct populations of calcium channels in a clonal line of pituitary cells (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-04
    Description: The whole-cell variant of the patch clamp technique was used to study calcium channels in GH3 cells. Two distinct populations of calcium channels, first recognized from their closing kinetics, were observed. The slowly closing channels are activated in a relatively negative voltage range and are inactivated within 100 milliseconds. They conduct barium and calcium about equally well. The fast closing channels are activated at more positive voltages, are not inactivated during a 100-millisecond pulse, conduct barium in preference to calcium, and are activated slightly more rapidly than the slowly closing channels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Armstrong, C M -- Matteson, D R -- New York, N.Y. -- Science. 1985 Jan 4;227(4682):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2578071" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Barium/metabolism ; Calcium/*metabolism ; Clone Cells ; Electrophysiology ; Ion Channels/metabolism/*physiology ; Kinetics ; Membrane Potentials ; Pituitary Gland/*cytology/metabolism ; Rats
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    Fluorescence digital imaging microscopy in cell biology (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-18
    Description: Developments in microscope, sensor, and image-processing technologies have led to integrated systems for the quantification of low-light-level emission signals from biological samples. Specificity is provided in the form of monoclonal antibodies and other ligands or enzyme substrates conjugated with efficient fluorophores. Fluorescent probes are also available for cellular macromolecular constituents and for free ions of biological interest such as H+ and Ca2+. The entire spectrum of photophysical phenomena can be exploited. Representative data are presented from studies of DNA conformation and architecture in polytene chromosomes and from studies of receptor-mediated endocytosis, calcium distribution, and the organization of the contractile apparatus in muscle cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arndt-Jovin, D J -- Robert-Nicoud, M -- Kaufman, S J -- Jovin, T M -- FO6 TWOO960/TW/FIC NIH HHS/ -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):247-56.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048934" target="_blank"〉PubMed〈/a〉
    Keywords: Analog-Digital Conversion ; Animals ; Cell Cycle ; Cells/*cytology ; Cells, Cultured ; Chromosomes/ultrastructure ; Drosophila ; Fluorescent Dyes ; Kinetics ; Microscopy, Fluorescence/instrumentation/*methods ; Salivary Glands/cytology
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    Plasticity of the differentiated state (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-11-15
    Description: Heterokaryons provide a model system in which to examine how tissue-specific phenotypes arise and are maintained. When muscle cells are fused with nonmuscle cells, muscle gene expression is activated in the nonmuscle cell type. Gene expression was studied either at a single cell level with monoclonal antibodies or in mass cultures at a biochemical and molecular level. In all of the nonmuscle cell types tested, including representatives of different embryonic lineages, phenotypes, and developmental stages, muscle gene expression was induced. Differences among cell types in the kinetics, frequency, and gene dosage requirements for gene expression provide clues to the underlying regulatory mechanisms. These results show that the expression of genes in the nuclei of differentiated cells is remarkably plastic and susceptible to modulation by the cytoplasm. The isolation of the genes encoding the tissue-specific trans-acting regulators responsible for muscle gene activation should now be possible.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blau, H M -- Pavlath, G K -- Hardeman, E C -- Chiu, C P -- Silberstein, L -- Webster, S G -- Miller, S C -- Webster, C -- GM07149/GM/NIGMS NIH HHS/ -- GM26717/GM/NIGMS NIH HHS/ -- HD18179/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Nov 15;230(4727):758-66.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2414846" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Animals ; Antibodies, Monoclonal ; *Cell Differentiation ; Cell Fusion ; Cell Nucleus/ultrastructure ; Epidermis/cytology ; Fetus/metabolism ; Fibroblasts/cytology ; Gene Expression Regulation ; Genes ; HeLa Cells/metabolism ; Humans ; Hybrid Cells/metabolism ; Keratins/physiology ; Kinetics ; Liver/cytology ; Mice ; Muscle Development ; Muscles/cytology ; Myosins/genetics ; Phenotype ; Transcription, Genetic ; Transcriptional Activation
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    Antibody-directed urokinase: a specific fibrinolytic agent (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-23
    Description: A specific fibrinolytic agent was synthesized by covalently coupling urokinase to a monoclonal antibody that was fibrin-specific and did not cross-react with fibrinogen. The antibody was raised against a synthetic peptide representing the seven amino-terminal residues of the beta chain of human fibrin. The urokinase-antifibrin conjugate retained the original binding specificity of the antibody and showed 100-fold increased fibrinolysis in vitro when compared to unmodified urokinase. The presence of human fibrinogen at plasma concentration did not influence these properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bode, C -- Matsueda, G R -- Hui, K Y -- Haber, E -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):765-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023710" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal/*therapeutic use ; Cross-Linking Reagents ; Fibrin/immunology ; *Fibrinolysis ; Humans ; In Vitro Techniques ; Kinetics ; Structure-Activity Relationship ; Urokinase-Type Plasminogen Activator/*administration & dosage
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    Matrix-driven translocation of cells and nonliving particles (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-05-17
    Description: Cells of metazoan organisms produce and react to complex macromolecular microenvironments known as extracellular matrices. Assembly in vitro of native, compositionally nonuniform collagen-fibronectin matrices caused translocation of certain types of cells or polystyrene-latex beads from regions lacking fibronectin into regions containing it. The translocation process was not due to diffusion, convection, or electrostatic distribution effects, but may depend on nonequilibrium phenomena at the interface of contiguous collagen matrices formed in the presence and absence of fibronectin or particles. Extracellular matrix formation alone was sufficient to drive translocation by a biophysical process that may play a role in cellular migration during embryogenesis, as well as in other types of tissue reorganization such as inflammation, wound healing, and tumor invasion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newman, S A -- Frenz, D A -- Tomasek, J J -- Rabuzzi, D D -- HD18148/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1985 May 17;228(4701):885-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001925" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cartilage/cytology/embryology ; *Cell Movement/drug effects ; Chick Embryo ; Collagen/*pharmacology ; Diffusion ; Extracellular Matrix/*physiology ; Fibroblasts/cytology ; Fibronectins/*pharmacology ; Humans ; In Vitro Techniques ; Kinetics ; Microspheres ; Movement
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    Positron emission tomography: human brain function and biochemistry (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-17
    Description: Positron emission tomography (PET) is an analytical imaging technique that provides a way of making in vivo measurements of the anatomical distribution and rates of specific biochemical reactions. This ability of PET to measure and image dynamic biochemistry builds a bridge between the basic and clinical neurosciences founded on the commonality of the types of measurements made. Clinical findings with PET in humans are suggesting hypotheses that can be tested rigorously in the basic science laboratory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Phelps, M E -- Mazziotta, J C -- P01-NS-15654/NS/NINDS NIH HHS/ -- R01-6M-248389/PHS HHS/ -- R01-MH-37916-02/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 May 17;228(4701):799-809.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2860723" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Bipolar Disorder/metabolism ; Brain/metabolism/*radionuclide imaging ; Brain Diseases/metabolism/*radionuclide imaging ; Brain Neoplasms/metabolism/radionuclide imaging ; Cerebrovascular Circulation ; Cerebrovascular Disorders/metabolism/radionuclide imaging ; Deoxyglucose/analogs & derivatives/metabolism ; Fluorodeoxyglucose F18 ; Glucose/metabolism ; Humans ; Huntington Disease/metabolism/radionuclide imaging ; Kinetics ; Mental Disorders/metabolism ; Neurotransmitter Agents/metabolism ; Oxygen Consumption ; Pharmaceutical Preparations/metabolism ; Pharmacology ; Photic Stimulation ; *Tomography, Emission-Computed ; Visual Cortex/physiology/radionuclide imaging
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    A strong influence of serotonin axons on beta-adrenergic receptors in rat brain (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-18
    Description: The role of serotonin axons in modulating the norepinephrine neurotransmission system in rat brain was investigated. Selective lesions of the forebrain serotonergic system were made by injecting 5,7-dihydroxytryptamine into the midbrain raphe nuclei. Four to six weeks after the lesion, the uptake of 3H-labeled serotonin in the frontal cortex and the hippocampus was reduced by more than 90 percent, while neither the uptake of 3H-labeled norepinephrine nor the content of norepinephrine was affected in either tissue. The number of beta-adrenergic receptors, as measured by radioligand binding with 3H-labeled dihydroalprenolol, was increased in the frontal cortex and hippocampus of rats with lesions. Similarly, specific lesions of central serotonin axons produced by systemically administered p-chloramphetamine resulted in an increase in the binding of 3H-labeled dihydroalprenolol to beta-adrenergic receptors and in the production of adenosine 3',5'-monophosphate in response to isoproterenol. These results indicate that serotonin axons may regulate beta-adrenergic receptor number and function in brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stockmeier, C A -- Martino, A M -- Kellar, K J -- MH08982/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996132" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Cerebral Cortex/*metabolism ; Clonidine/analogs & derivatives/metabolism ; Dihydroalprenolol/metabolism ; Hippocampus/*metabolism ; Kinetics ; Male ; Norepinephrine/metabolism ; Prazosin/metabolism ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic, beta/*metabolism ; Serotonin/*physiology
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    Rate theories and puzzles of hemeprotein kinetics (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-07-26
    Description: The binding of dioxygen and carbon monoxide to heme proteins such as myoglobin and hemoglobin has been studied with flash photolysis. At temperatures below 200 K, binding occurs from within the heme pocket and, contrary to expectation, with nearly equal rates for both ligands. This observation has led to a reexamination of the theory of the association reaction taking into account friction, protein structure, and the nature of electronic transitions. The rate coefficients for the limiting cases of large and small friction are found with simple arguments that use characteristic lengths and times. The arguments indicate how transition state theory as well as calculations based on nonadiabatic perturbation theory, which is called the Golden Rule, may fail. For ligand-binding reactions the data suggest the existence of intermediate states not directly observed so far. The general considerations may also apply to other biomolecular processes such as electron transport.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frauenfelder, H -- Wolynes, P G -- GM 18051/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 Jul 26;229(4711):337-45.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012322" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon Monoxide/metabolism ; Hemeproteins/*metabolism ; Hemoglobins/metabolism ; Humans ; Kinetics ; Mathematics ; Myoglobin/metabolism ; Oxygen/metabolism ; Spectrophotometry, Infrared ; Spectrum Analysis, Raman ; Thermodynamics
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    Enzyme regulation in a trypanosomatid: effect of purine starvation on levels of 3'-nucleotidase activity (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-04
    Description: Crithidia fasciculata, a nonpathogenic relative of the leishmanial and trypanosomal pathogens of humans and animals, showed a 3'-ribonucleotidase activity similar to that in Leishmania donovani. The level of 3'-nucleotidase activity in Crithidia was regulated by the availability of purines in the culture medium. Specifically, organisms obtained from culture medium depleted of purines contained elevated levels of enzyme activity compared to those grown in complete medium. The 3'-nucleotidase, located at the cell surface, may serve as a first step in purine salvage for these protozoa, which are unable to synthesize the purine ring de novo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gottlieb, M -- AI-16530/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1985 Jan 4;227(4682):72-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2981117" target="_blank"〉PubMed〈/a〉
    Keywords: 5'-Nucleotidase ; Acid Phosphatase/metabolism ; Adenosine/pharmacology ; Crithidia/drug effects/*enzymology ; Culture Media ; Kinetics ; Nucleotidases/*metabolism ; Purines/*pharmacology
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    Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-05-24
    Description: Experiments were conducted to test the hypothesis that tumor-derived transforming growth factor-alpha (TGF-alpha) is responsible for the increased bone resorption and hypercalcemia seen in some malignant diseases. Homogeneous synthetic TGF-alpha prepared by the solid-phase synthesis method stimulated bone resorption directly in vitro in a concentration-dependent manner. Incubation times of 72 hours or more were required to stimulate resorption, which is similar to the time course of bone resorption by epidermal growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ibbotson, K J -- Twardzik, D R -- D'Souza, S M -- Hargreaves, W R -- Todaro, G J -- Mundy, G R -- AM-28149/AM/NIADDK NIH HHS/ -- CA-29537/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 May 24;228(4702):1007-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3859011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Resorption/*drug effects ; Bone and Bones/drug effects ; Dose-Response Relationship, Drug ; History, 20th Century ; Kinetics ; Molecular Weight ; Organ Culture Techniques ; Peptides/chemical synthesis/*pharmacology ; Rats ; Transforming Growth Factors
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    Two types of somatostatin receptors differentiated by cyclic somatostatin analogs (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-04-26
    Description: Somatostatin receptors in rat brain, pituitary, and pancreas were labeled with two radioiodinated analogs of somatostatins 14 and 28. Two cyclic analogs of somatostatin, SMS201-995 and cyclo(Ala-Cys-Phe-D-Trp-Lys-Thr-Cys), showed biphasic displacement of binding to somatostatin receptors by these radioligands. In contrast, all other somatostatin analogs, including somatostatin-14, competed for the receptor sites with monophasic displacement of radioligand receptor binding. Thus two types of somatostatin receptors were identified. It was found that the pituitary and pancreas have predominantly one type of somatostatin receptor whereas the brain has both, and that different regions of the brain have various proportions of the two types. These findings suggest methods to characterize other types of somatostatin receptors subserving somatostatin's diverse physiological functions, including a potential role in cognitive function and extrapyramidal motor system control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tran, V T -- Beal, M F -- Martin, J B -- NS16367/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Apr 26;228(4698):492-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2858917" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Brain/metabolism ; Kinetics ; Pancreas/metabolism ; *Peptides, Cyclic ; Pituitary Gland/metabolism ; Radioligand Assay ; Rats ; Receptors, Cell Surface/*classification/metabolism ; Receptors, Somatostatin ; Somatostatin/*analogs & derivatives
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    Monitoring the time course of cerebral deoxyglucose metabolism by 31P nuclear magnetic resonance spectroscopy (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-14
    Description: The phosphorylation of 2-deoxyglucose by the mammalian brain is used as an index of the brain's energy metabolism. The results of phosphorus-31 nuclear magnetic resonance (31P NMR) monitoring of conscious animals in vivo showed rapid phosphorylation of 2-deoxyglucose by brain tissue. The rate of phosphorylation as determined by 31P NMR was consistent with results achieved by tracer methods using carbon-14-labeled 2-deoxyglucose. However, the disappearance of 2-deoxyglucose-6-phosphate was shown to be faster than that reported by tracer studies and occurred without alterations of intracellular pH and energy homeostasis. These results were confirmed by gas chromatography and mass spectroscopy. It is postulated that 2-deoxyglucose may be metabolized in several ways, including dephosphorylation by a hexose phosphatase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deuel, R K -- Yue, G M -- Sherman, W R -- Schickner, D J -- Ackerman, J J -- AM-20579/AM/NIADDK NIH HHS/ -- GM-30331/GM/NIGMS NIH HHS/ -- RR 00954/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Jun 14;228(4705):1329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001946" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Kinetics ; Magnetic Resonance Spectroscopy ; Phosphorylation ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Flow effects on prostacyclin production by cultured human endothelial cells (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-22
    Description: Endothelial cell functions, such as arachidonic acid metabolism, may be modulated by membrane stresses induced by blood flow. The production of prostacyclin by primary human endothelial cell cultures subjected to pulsatile and steady flow shear stress was measured. The onset of flow led to a sudden increase in prostacyclin production, which decreased to a steady rate within several minutes. The steady-state production rate of cells subjected to pulsatile shear stress was more than twice that of cells exposed to steady shear stress and 16 times greater than that of cells in stationary culture.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frangos, J A -- Eskin, S G -- McIntire, L V -- Ives, C L -- HL-17437/HL/NHLBI NIH HHS/ -- HL-18672/HL/NHLBI NIH HHS/ -- HL-23016/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1985 Mar 22;227(4693):1477-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3883488" target="_blank"〉PubMed〈/a〉
    Keywords: *Blood Circulation ; Cells, Cultured ; Endothelium/cytology/*metabolism ; Epoprostenol/*biosynthesis ; Humans ; Kinetics ; Models, Biological ; Stress, Mechanical
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 68
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    Enzymatic removal of bilirubin from blood: a potential treatment for neonatal jaundice (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-11-01
    Description: Current treatments for severe jaundice can result in major complications. Neonatal jaundice is caused by excessive accumulation of bilirubin in the blood. A small blood filter containing immobilized bilirubin oxidase was developed to reduce serum bilirubin concentrations. When human or rat blood was passed through the enzyme filter, more than 90 percent of the bilirubin was degraded in a single pass. This procedure may have important applications in the clinical treatment of neonatal jaundice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavin, A -- Sung, C -- Klibanov, A M -- Langer, R -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):543-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048947" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bilirubin/*blood ; Blood ; Filtration ; Humans ; Jaundice, Neonatal/*blood/therapy ; Kinetics ; Methods ; Oxidoreductases/metabolism ; *Oxidoreductases Acting on CH-CH Group Donors ; Rats ; Sepharose
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 69
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    Evidence that the v-sis gene product transforms by interaction with the receptor for platelet-derived growth factor (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-18
    Description: A scheme for partial purification of biologically active v-sis-coded protein from cells transformed with simian sarcoma virus (SSV) has made possible a functional comparison of the transforming protein with platelet-derived growth factor (PDGF). The SSV-transforming gene product is capable of specifically binding PDGF receptors, stimulating tyrosine phosphorylation of PDGF receptors, and inducing DNA synthesis in quiescent fibroblasts. Each of these activities was specifically inhibited by antibodies to different regions of the v-sis gene product. Moreover, viral infection of a variety of cell types revealed a strict correlation between those cells possessing PDGF receptors and those susceptible to transformation by SSV. These findings provide evidence that SSV-transforming activity is mediated by the interaction of a virus-coded mitogen with PDGF receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leal, F -- Williams, L T -- Robbins, K C -- Aaronson, S A -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):327-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996133" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/metabolism ; Cattle ; Cell Line ; *Cell Transformation, Viral ; Cells, Cultured ; Fibroblasts/metabolism ; *Genes ; *Genes, Viral ; Humans ; Kinetics ; Mink ; Molecular Weight ; Muscle, Smooth/metabolism ; Muscle, Smooth, Vascular/metabolism ; Platelet-Derived Growth Factor/*metabolism ; Receptors, Cell Surface/isolation & purification/*metabolism ; Receptors, Platelet-Derived Growth Factor ; Retroviridae/*genetics ; Sarcoma Virus, Woolly Monkey/*genetics ; Viral Proteins/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 70
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    Detection of DNA sequences in nuclei in suspension by in situ hybridization and dual beam flow cytometry (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-20
    Description: This report describes the fluorescence hybridization of DNA sequence probes to interphase nuclei in suspension and the quantification of bound probe by dual beam flow cytometry. Nuclear proteins were first cross-linked with dimethylsuberimidate to prevent disintegration of the nuclei during denaturation and hybridization. To demonstrate that in situ hybridization can be performed in suspension, stabilized mouse thymocyte nuclei were hybridized with a probe for mouse satellite DNA sequences. The DNA probes were labeled with 2-acetylaminofluorene. After hybridization, an indirect immunofluorescent labeling procedure was used to visualize the target sequences. With dual beam flow cytometry, both the amount of hybridized probe and the DNA content of individual nuclei were determined. Thus, the specificity of DNA hybridization can be combined with the speed and quantitative analysis provided by flow cytometry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trask, B -- van den Engh, G -- Landegent, J -- in de Wal, N J -- van der Ploeg, M -- New York, N.Y. -- Science. 1985 Dec 20;230(4732):1401-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2416058" target="_blank"〉PubMed〈/a〉
    Keywords: 2-Acetylaminofluorene/pharmacology ; Animals ; Base Sequence ; Bisbenzimidazole ; DNA/*genetics ; DNA, Satellite/genetics ; Dimethyl Suberimidate/pharmacology ; Flow Cytometry/methods ; Humans ; Kinetics ; Mice ; *Nucleic Acid Hybridization ; Thymus Gland/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 71
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    Leukotrienes as mediators in tissue trauma (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-18
    Description: A significant increase in the production of cysteinyl leukotrienes was observed after mechanical or thermal trauma in the anesthesized rat. The amount of biliary N-acetyl-leukotriene E4, which represents a suitable indicator for blood plasma leukotrienes, was used as a measure of leukotriene generation. Cysteinyl leukotrienes were rapidly eliminated from blood plasma into bile where N-acetyl-leukotriene E4 was the major metabolite. Leukotrienes were at a much lower concentration in blood plasma than in bile and differed in the pattern of metabolites. The detected amounts of leukotrienes were sufficient to induce known phenomena associated with trauma, such as tissue edema and circulatory and respiratory dysfunction. Increased leukotriene generation appears to play an important role in the pathophysiology of tissue trauma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Denzlinger, C -- Rapp, S -- Hagmann, W -- Keppler, D -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048937" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta, Abdominal/injuries ; Bile/metabolism ; Bile Ducts/surgery ; Burns/physiopathology ; Female ; Fractures, Bone/physiopathology ; Half-Life ; Kinetics ; Rats ; Rats, Inbred Strains ; SRS-A/*biosynthesis/blood ; Tritium ; Wounds and Injuries/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 72
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    Abrupt induction of a membrane digestive enzyme by its intraintestinal substrate (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-04
    Description: The regulation of amino-oligopeptidase (AOP), an intestinal brush border hydrolase essential for the surface digestion of peptide nutrients, was examined in rats in vivo. Short-term (30-minute) intraintestinal perfusion of a tetrapeptide substrate, Gly-Leu-Gly-Gly, or a synthetic substrate, leucyl-beta-naphthylamide, induced a doubling in the incorporation of [3H]leucine into the AOP in association with intracellular membranes. The subsequent conversion of AOP from nascent to mature enzyme and its membrane-associated transport to the brush border occurred at normal rates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reisenauer, A M -- Gray, G M -- AM 07056/AM/NIADDK NIH HHS/ -- AM 11270/AM/NIADDK NIH HHS/ -- AM 15802/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Jan 4;227(4682):70-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3838079" target="_blank"〉PubMed〈/a〉
    Keywords: Aminopeptidases/*biosynthesis ; Animals ; *Antigens, CD13 ; Dietary Proteins/metabolism ; Digestion ; Endoplasmic Reticulum/metabolism ; Enzyme Induction ; Golgi Apparatus/metabolism ; Intestines/*enzymology ; Kinetics ; Leucine/analogs & derivatives/metabolism ; Male ; Microvilli/enzymology ; Oligopeptides/metabolism ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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