Publication Date:
1981-10-23
Description:
The complete nucleotide sequence of a mammalian transforming retrovirus. Moloney murine sarcoma virus, has been determined. MSV, recombinant virus derived of helper viral and cellular sequences, possesses termini resembling prokaryotic transposable elements. The viral genome has the coding capacity for the Moloney murine leukemia virus gag gene product and contains large deletions in pol and env genes. A large open reading frame encompassing its cell-derived sequences codes for its putative transforming protein. The nature of some of the important domains in the viral genome has been established, and their structure is discussed in relation to their function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, E P -- Smith, M J -- Aaronson, S A -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):445-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6170110" target="_blank"〉PubMed〈/a〉
Keywords:
Antigens, Viral/genetics
;
Base Sequence
;
Binding Sites
;
Cell Transformation, Viral
;
DNA, Viral/*genetics
;
Defective Viruses/genetics
;
Gene Products, gag
;
*Genes, Viral
;
Moloney murine leukemia virus/*genetics
;
RNA, Transfer/genetics
;
RNA-Directed DNA Polymerase/genetics
;
Repetitive Sequences, Nucleic Acid
;
Sarcoma Viruses, Murine/*genetics
;
Transcription, Genetic
;
Viral Proteins/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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