Cyclophosphamide-induced spermatogenic effects detected in the F1 generation by behavioral testing

Science. 1981 Jan 2;211(4477):80-2. doi: 10.1126/science.7444453.

Abstract

Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.

MeSH terms

  • Animals
  • Avoidance Learning
  • Behavior, Animal / physiology*
  • Cyclophosphamide / pharmacology*
  • Female
  • Locomotion
  • Male
  • Motor Activity
  • Mutation
  • Rats
  • Spermatogenesis / drug effects*

Substances

  • Cyclophosphamide