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  • Mice  (56)
  • Cats
  • American Association for the Advancement of Science (AAAS)  (70)
  • American Association of Petroleum Geologists (AAPG)
  • Nature Publishing Group
  • 2015-2019
  • 1975-1979  (70)
  • 1940-1944
  • 1978  (70)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (70)
  • American Association of Petroleum Geologists (AAPG)
  • Nature Publishing Group
  • Springer  (1)
Years
  • 2015-2019
  • 1975-1979  (70)
  • 1940-1944
Year
  • 1
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    Cholinergic vesicles: ability to empty and refill independently of cytoplasmic acetylcholine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: Incubation of minced mouse-forebrain tissues in lithium Krebs solution reduces the acetylcholine content of the vesicular fraction 70 percent without altering that of the cytoplasmic fraction. Depleted vesicular-bound acetylcholine can be restored with newly synthesized acetylcholine (formed from extracellular choline) independently of the cytoplasmic pool. Depletion of vesicular-bound acetylcholine does not facilitate the movement of preformed extracellular acetylcholine into vesicles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carrol, P T -- Nelson, S H -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):85-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Toxicology, University of Rhode Island, Kingston, RI 02881, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569492" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*metabolism ; Animals ; Cholinesterase Inhibitors/pharmacology ; Cytoplasm/*metabolism ; Cytoplasmic Vesicles/drug effects/*metabolism ; Lithium Compounds/pharmacology ; Male ; Mice ; Paraoxon/pharmacology ; Prosencephalon/drug effects/*metabolism/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Rabies viruses increase in virulence when propagated in neuroblastoma cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-10
    Description: Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, H F -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1072-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628831" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured ; Mice ; Neuroblastoma/*microbiology ; Neurons/microbiology ; Rabies Vaccines/toxicity ; Rabies virus/genetics/*pathogenicity ; Vaccines, Attenuated/toxicity ; Virus Replication
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Pontine reticular formation neurons and motor activity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, B -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):207-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619453" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Eye Movements ; Humans ; Motor Neurons/*physiology ; Reticular Formation/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Rejection of male skin grafts by splenectomized female mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: Female mice of the C3H strain normally do not reject skin grafts from males of the same strain; however, 40 percent of splenectomized C3H female mice completely rejected C3H male skin grafts applied 2 weeks later. All splenectomized females showed at least transitory signs of graft rejection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coons, T A -- Goldberg, E H -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/345443" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; *Graft Rejection ; *Histocompatibility Antigens ; Immunosuppression ; Male ; Mice ; Mice, Inbred C3H/immunology ; Skin Transplantation ; Spleen/*immunology ; Transplantation, Homologous ; Y Chromosome
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Physiological basis of anisometropic amblyopia (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-21
    Description: In the visual cortex of kittens that have received their only visual experience while wearing a high-power lens before one eye, most neurons are dominated by input from the normal eye. Moreover, contrast sensitivity and resolving power are lower for stimulation through the originally defocused eye, mimicking psychophysical results from human anisometropic amblyopes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eggers, H M -- Blakemore, C -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):264-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663654" target="_blank"〉PubMed〈/a〉
    Keywords: Amblyopia/*physiopathology ; Animals ; Brain Mapping ; Cats ; Disease Models, Animal ; Orientation/physiology ; Refractive Errors/*physiopathology ; Visual Cortex/*physiopathology ; Visual Pathways/physiopathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Dual actions of substance P on nociception: possible role of endogenous opioids (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Substance P produces analgesia when administered to mice in very small doses by the intraventricular route (1.25 to 5 nanograms per mouse). The analgesic effect can be blocked by naloxone. At higher doses (greater than 50 nanograms per mouse), this activity is lost. At these higher doses, however, substance P produced hyperalgesia when combined with naloxone and analgesia when combined with baclofen [beta-(4-chlorophenyl)-gamma-aminobutyric acid]. Substance P may have dual actions in brain, releasing endorphins at very low doses and directly exciting neuronal activity in nociceptive pathways at higher doses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frederickson, R C -- Burgis, V -- Harrell, C E -- Edwards, J D -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1359-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204012" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Baclofen/pharmacology ; Dose-Response Relationship, Drug ; Endorphins/*pharmacology ; Enkephalins/antagonists & inhibitors/*pharmacology ; Mice ; Naloxone/pharmacology ; Nociceptors/*drug effects ; Receptors, Opioid/*drug effects ; Structure-Activity Relationship ; Substance P/analogs & derivatives/antagonists & inhibitors/*pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Evoked response correlate of symbol and significate (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: Changing the source and intensity of the auditory signal to six trained cats responding to meaningful auditory stimuli permits exogenous and endogenous processes in the auditory evoked potential to be separated. For short-latency exogenous processes, latency and amplitude depend on the parameters of the physical stimulus. However, the amplitude and shape of longer-latency endogenous processes are essentially independent of the location and intensity of the signal source and seem to be invariant concomitants of the significance of the signal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grastyan, E -- John, E R -- Bartlett, F -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):169-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663648" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Cats ; Conditioning (Psychology)/physiology ; Discrimination (Psychology)/*physiology ; *Evoked Potentials ; Geniculate Bodies/*physiology ; Memory/physiology
    Print ISSN: 0036-8075
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  • 8
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    Nicotinamide adenine dinucleotide splitting enzyme: a characteristic of the mouse macrophage (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Murine macrophages are endowed with nicotinamide adenine dinucleotide splitting activity that is markedly higher than that of other cells, tissues, or organs of the mouse. This enzyme therefore can be used as a biochemical marker for distinguishing macrophages from other cells of the lymphoreticular system and from polymorphonuclear leukocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Artman, M -- Seeley, R J -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1293-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214853" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascitic Fluid/enzymology ; B-Lymphocytes/enzymology ; Blood Platelets/enzymology ; Bone Marrow/enzymology ; Humans ; Lymph Nodes/enzymology ; Macrophages/*enzymology ; Mice ; Monocytes/enzymology ; NAD+ Nucleosidase/*metabolism ; Neutrophils/enzymology ; Spleen/enzymology ; T-Lymphocytes/enzymology ; Tissue Distribution
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: Impure and pure samples of saccharin (2 milligrams per milliliter) did not produce oncogenic transformation of C3H/10T1/2, clone 8, mouse embryo fibroblasts. However, after treatment of the cells with a nontransforming initiating dose (0.1 microgram per milliliter) of 3-methylcholanthrene, continuous treatment with either sample of saccharin (100 micrograms per milliliter) led to significant transformation. It is concluded that in this system saccharin is a cocarginogen, probably functioning as a promoting agent that is 1000-fold less active than the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mondal, S -- Brankow, D W -- Heidelberger, C -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1141-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684434" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Cell Line ; Cell Transformation, Neoplastic/*chemically induced ; Cocarcinogenesis ; Embryo, Mammalian ; Methylcholanthrene ; Mice ; Mice, Inbred C3H ; Saccharin/*pharmacology ; Tetradecanoylphorbol Acetate
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Identification of a C-glucuronide of delta6- tetrahydrocannabinol as a mouse liver conjugate in vivo (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: Delta 6-Tetrahydrocannabinol-C-4-glucuronide was found in the livers of mice that had been administered delta 6-tetrahydrocannabinol. Thus, C-glucuronidation of a compound that contains a free hydroxyl group has been demonstrated in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, S -- Yagen, B -- Mechoulam, R -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1390-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663618" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dronabinol/*analogs & derivatives/metabolism ; Glucuronates/metabolism ; Liver/*metabolism ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: The inability of nursing pups to survive on milk of mice homozygous for the recessive mutation, lethal milk (lm), is correlated with a reduction in zinc levels of both milk and pup carcass. Administration of zinc to pups nursing on lmlm dams reduces the observed mortality and morbidity. It is suggested that lm alters zinc transport from maternal blood to milk and that its study may provide useful information for understanding the rare human disease, acrodermatitis enteropathica.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piletz, J E -- Ganschow, R E -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; *Lactation ; Mice ; Mice, Inbred C57BL/*genetics ; Milk/*metabolism ; Pregnancy ; Zinc/blood/*deficiency/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Generation of new mouse sarcoma viruses in cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Endogenous nontumor-producing type C viruses from C3H mice were used to generate rapid, solid tumor-inducing variants in cell culture. The new mouse sarcoma viruses induce undifferentiated sarcomas with a short latency period upon inoculation into newborn NIH Swiss mice. Transforming viruses appear only transiently, at a time when the virus-infected cells show morphologic alterations; both before and after this time, transforming viruses cannot be detected. These results show that variants of endogenous type C virus which contain transforming genes (oncogenes) can arise during spread of the endogenous virus in fibroblast lines in vitro as well as in susceptible tissues in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rapp, U R -- Todaro, C -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):821-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210501" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; *Cell Transformation, Neoplastic ; Cell Transformation, Viral ; *Genes, Viral ; Mice ; Retroviridae/genetics/*pathogenicity ; Sarcoma Viruses, Murine/genetics/pathogenicity ; Sarcoma, Experimental/*microbiology
    Print ISSN: 0036-8075
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  • 13
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    Acoustic microscopy: a new window to the world of the small (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1110-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684431" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustics/*instrumentation ; Animals ; Blood Cells/ultrastructure ; Mice ; Microscopy/*instrumentation/methods ; Muscles/ultrastructure ; Myocardium/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Prenatal exposure to prednisone in humans and animals retards intrauterine growth (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-27
    Description: Prednisone treatment for infertility and subsequent pregnancy maintenance in humans resulted in a significant decrease in the birth weight of full-term infants and a marked increase in the percentage of newborn infants weighing 2500 grams or less, that is, "light for dates" in comparison to control offspring. A parallel experiment with mice indicated that the reduction of birth weight was caused by exposure to corticosteroids rather than to maternal disease or malfunction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reinisch, J M -- Simon, N G -- Karow, W G -- Gandelman, R -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):436-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705336" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birth Weight/*drug effects ; Female ; Fetus/*drug effects ; Humans ; *Infant, Low Birth Weight ; Infant, Newborn ; Male ; Mice ; Prednisone/*adverse effects ; Pregnancy/*drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Terminal arbors of axons that have formed abnormal connections (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: Ther terminal arbors of individual retinogeniculate axons that have been induced to grow into an inappropriate geniculate layer have been revealed for light and electron microscopic study by being filled with horseradish peroxidase. After a unilateral ocular enucleation in kittens, single axons from the surviving eye show terminal arbors not only within their own geniculate layers but also in the denervated layers. The new, abnormal arbors arise from the terminal segments of arbors that lie within the nondenervated layer and make patterns of synaptic contacts that appear normal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robson, J A -- Mason, C A -- Guillery, R W -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):635-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675248" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*ultrastructure ; Cats ; Eye/innervation ; Geniculate Bodies/*ultrastructure ; Synapses/*ultrastructure ; Visual Pathways/*ultrastructure
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  • 16
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    Is pump stimulation associated with positive inotropy of the heart? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-16
    Description: A purified sodium and potassium dependent adenosinetriphosphatase isolated from cat heart was not stimulated by any concentration of ouabain that produced positive inotropy of cat papilliary muscle. Only inhibition of enzyme activity was observed. Concentrations of ouabain used ranged from 3.3 x 10(-10) molar to 5 x 10(-7) molar and produced an increased force of contraction without any evidence of toxicity. The results are inconsistent with a concept that stimulation of sodium pump activity is associated with positive inotropy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michael, L -- Pitts, B J -- Schwartz, A -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1287-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/149369" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/*antagonists & inhibitors ; Animals ; Biological Transport, Active/drug effects ; Cats ; Dose-Response Relationship, Drug ; In Vitro Techniques ; Myocardial Contraction/*drug effects ; Myocardium/*enzymology ; Ouabain/*pharmacology ; Potassium/metabolism ; Sodium/metabolism
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  • 17
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    delta9-tetrahydrocannabinol: antiaggressive effects in mice, rats, and squirrel monkeys (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: delta9-Tetrahydrocannabinol, the most active constituent of marihuana, decreased species-specific attack behavior in mice, rats, and squirrel monkeys at doses (0.25 to 2.0 milligram per kilogram of body weight) that have no effects on other elements of the behavioral repertoire. Aggressive behavior was engendered in all three species by confronting a resident animal with an intruder conspecific. The present results contrast with the widely held belief that marihuana increases aggressive behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miczek, K A -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415367" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*drug effects ; Animals ; Behavior, Animal/*drug effects ; Depression, Chemical ; Dose-Response Relationship, Drug ; Dronabinol/*pharmacology ; Female ; Haplorhini ; Humans ; Male ; Mice ; Motor Activity/drug effects ; Rats ; Saimiri ; Territoriality
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  • 18
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    Aminophylline increases cerebral metabolic rate and decreases anoxic survival in young mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: In weanling mice treated with pharmacologic doses of aminophylline, the concentrations of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in the brain increased 44 and 36 percent, respectively, and the cerebral metabolic rate was three times that in controls. In neonatal mice, therapeutic doses of aminophylline greatly decreased the rate of anoxic survival in vivo and the duration of gasping of the isolated head. The findings suggest caution in the use of this drug and other methylxanthines in hypoxic human newborns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thurston, J H -- Hauhard, R E -- Dirgo, J A -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):649-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/209541" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/metabolism ; Aminophylline/*pharmacology/therapeutic use ; Animals ; Anoxia/physiopathology ; Apnea/drug therapy ; Brain/drug effects/*metabolism ; Cheyne-Stokes Respiration/drug therapy ; Cyclic AMP/metabolism ; Energy Metabolism/*drug effects ; Glucose/metabolism ; Glucosephosphates/metabolism ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/drug therapy ; Mice
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  • 19
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    Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-30
    Description: A single injection of 5 or 10 microliters of ferrous or ferric chloride into rat or cat sensorimotor cortex resulted in chronic recurrent focal paroxysmal electroencephalographic discharges as well as behavioral convulsions and electrical seizures. Recurrent focal epileptiform discharge caused by cortical injection of iron salts suggests that the development of human posttraumatic epilepsy may depend, in part, on the neurochemical alterations induced by the principal metallic ions found in whole blood.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willmore, L J -- Sypert, G W -- Munson, J V -- Hurd, R W -- New York, N.Y. -- Science. 1978 Jun 30;200(4349):1501-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/96527" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Cerebral Cortex/*drug effects/physiopathology ; *Disease Models, Animal ; Electrophysiology ; Epilepsies, Partial/*chemically induced ; Ferric Compounds ; Ferrous Compounds ; *Iron ; Rats ; Seizures/*chemically induced/physiopathology
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  • 20
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    Antibody diversity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, J G -- Leder, A -- Nau, M -- Norman, B -- Leder, P -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):11-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Specificity ; Base Sequence ; Binding Sites, Antibody/*genetics ; Biological Evolution ; Cell Line ; Embryo, Mammalian/immunology ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Recombination, Genetic
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  • 21
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    Opiate receptors for behavioral analgesia resemble those related to the depression of spinal nociceptive neurons (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: With naloxone as antagonist, a dose-ratio analysis of the depression by morphine of nociceptive neurons in the spinal cord reveals that this opiate depression of single unit activity has the same pharmacological properties as observed with morphine analgesia. This suggests that the opiate receptor, mediating the observed cellular depression, and those mediating analgesia are presumably the same.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yaksh, T L -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1231-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204008" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Cats ; Decerebrate State ; Dose-Response Relationship, Drug ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Nerve Fibers/physiology ; Nociceptors/*drug effects/physiology ; Receptors, Opioid/*physiology ; Spinal Cord/physiology
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  • 22
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    Effect of oxygen pressure during culture on survival of mouse thyroid allografts (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-02
    Description: A marked increase in the percentage of mouse thyroids that retained function 20 days after transplantation across a major histocompatibility barrier and the percentage that lacked generalized infiltration was observed when the grafts received hyperbaric oxygen during a 4-day culture period. Perfusion of the donor animal before thyroidotomy and the addition of fetal calf serum to the culture medium did not have a significant effect on graft survival, but the percentage of grafts lacking generalized infiltration was slightly increased by the addition of hydrocortisone to the culture medium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talmage, D W -- Dart, G A -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1066-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653355" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood ; Culture Media ; *Graft Survival/drug effects ; Hydrocortisone/pharmacology ; *Hyperbaric Oxygenation ; Mice ; Organ Culture Techniques/*methods ; Thyroid Gland/*transplantation ; Transplantation, Homologous
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  • 23
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    Pierce's disease of grapevines: isolation of the causal bacterium (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: A Gram-negative, rod-shaped bacterium has been consistently isolated from grapevines with Pierce's disease. Grapevines inoculated with the bacterium developed Pierce's disease, and the bacterium was reisolated from the plants. The bacterium was serologically and ultrastructurallv indistinguishable from the one in naturally infected plants, and also indistinguishable from a bacterium isolated from almonds with almond leaf scorch disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, M J -- Purcell, A H -- Thomson, S V -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):75-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Pathology, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569487" target="_blank"〉PubMed〈/a〉
    Keywords: Agglutination Tests ; Animals ; Cell Wall/ultrastructure ; Gram-Negative Bacteria/cytology/immunology/*isolation & ; purification/pathogenicity ; Hemiptera/microbiology ; Insect Vectors/microbiology ; Male ; Mice ; Plant Diseases/*microbiology ; Prunus/microbiology ; Rabbits ; Vitis/*microbiology
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  • 24
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    Interaction of critical periods in the visual cortex of kittens (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-02-03
    Description: The critical period for modifying the preferred direction in cat cortical units occurs earlier than that for monocular deprivation. The independence of the effects of these two types of deprivation from each other was tested by rearing six kittens with both reverse suture and reversed directional deprivation. The kittens were placed in a drum rotating in one direction with one eye open at ages 2 1/2 to 5 weeks; the drum rotation was reversed and the other eye opened when they were 5 to 12 weeks old. Recordings were then made in the visual cortex. The results were the sum of the effects of reverse suture and reversal of directional deprivation: most cells were driven by the eye that was open second, and most unidirectional cells preferred the direction to which the animals were exposed first. Consequently, many unidirectional cells preferred the first direction but were driven by the eye open second--a combination that the animal never saw during rearing. There was also an effect of ocular deprivation on directional properties and vice versa: reverse suture reduced the overall percentage of unidirectional cells, just as directional deprivation has been shown to affect the ocular dominance histogram. This result suggests that the same cells may be affected by both forms of deprivation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daw, N W -- Berman, N E -- Ariel, M -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):565-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622560" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Cats ; Cell Differentiation ; Functional Laterality ; Motion Perception/physiology ; *Vision, Ocular ; Visual Cortex/cytology/*growth & development ; Visual Pathways/growth & development ; Visual Perception/physiology
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  • 25
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    (S)-9-(2,3-Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: (S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Clercq, E -- Descamps, J -- De Somer, P -- Holy, A -- New York, N.Y. -- Science. 1978 May 5;200(4341):UNKNOWN.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205946" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine/*analogs & derivatives/pharmacology ; Animals ; *Antiviral Agents ; Cytopathogenic Effect, Viral/drug effects ; Female ; Measles virus/drug effects ; Mice ; Simplexvirus/drug effects ; Vaccinia virus/drug effects ; Vesicular stomatitis Indiana virus/drug effects ; Virus Replication/*drug effects
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  • 26
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    Ethanol: modifications of acute intoxication by divalent cations (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: Calcium, other divalent cations, and calcium antagonists were tested for their ability to alter ethanol-induced sleeping time, hypothermia, and behavioral intoxication in mice and rats. Calcium given intraventricularly significantly enhanced sleeping time and behavioral intoxication in a dose-related manner. The ionophores X537A and A23187 accentuated the effect of a low dose of calcium, whereas the calcium chelators EDTA and EGTA decreased sleeping time. Calcium also enhanced tertiary butanol- and chloral hydrate-induced sleeping time. The effects of cations on ethanol-induced hypothermia were less significant. The results suggest the existence of a central calcium pool that is involved in ethanol intoxication in rodents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erickson, C K -- Tyler, T D -- Harris, R A -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1219-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/343251" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholic Intoxication/*physiopathology ; Animals ; Body Temperature Regulation/drug effects ; Calcimycin/pharmacology ; Calcium/antagonists & inhibitors/*physiology ; Cations, Divalent ; Dose-Response Relationship, Drug ; Drug Synergism ; Female ; Humans ; Lasalocid/pharmacology ; Male ; Mice ; Movement/drug effects ; Rats
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  • 27
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    Sustained release of alcohol: subcutaneous silastic implants in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: A sustained-release device for use in ethanol dependence studies in mice is described. The Silastic device, dubbed SERT (sustained ethanol release tube), holds 0.35 milliliter of 95 percent ethanol (by volume) and is implanted under the skin of the back where it releases ethanol for up to 12 hours, with no observable tissue damage. The device may be adaptable to the release of other volatile liquids or drugs, in other animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erickson, C K -- Koch, K I -- Mehta, C S -- McGinity, J W -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1457-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/564551" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholic Intoxication/etiology ; Alcoholism/*etiology ; Animals ; *Disease Models, Animal ; Drug Administration Schedule ; Drug Implants ; Drug Tolerance ; Ethanol/*administration & dosage ; Humans ; Mice ; Silicone Elastomers
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  • 28
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    Genomic masking of nondefective recombinant murine leukemia virus in Moloney virus stocks (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: HIX virus cloned from Moloney leukemia virus stocks is a nondefective, leukemogenic, and amphotropic murine oncornavirus with a recombinant-type major glycoprotein. Although Moloney leukemia virus stocks generally contain little or no free amphotropic virus, dilution analysis of several virus stocks and the examination of virus progeny from individual foci revealed that HIX virus is present and functionally coated with ecotropic Moloney virus envelopes. Because most mice have serum factors that inactivate recombinant viruses, masking may represent a general survival mechanism for HIX as well as other analogous recombinant viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischinger, P J -- Blevins, C S -- Dunlop, N M -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):457-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663667" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Genes, Viral ; Glycoproteins/immunology ; Leukemia, Experimental/*microbiology ; Lymphoma/*microbiology ; Mice ; Mice, Inbred BALB C/microbiology ; Mice, Inbred Strains/microbiology ; Moloney murine leukemia virus/classification/*genetics/immunology ; Recombination, Genetic ; Species Specificity ; Viral Proteins/immunology
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  • 29
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    Memory: modification of anisomycin-induced amnesia by stimulants and depressants (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-20
    Description: Mice were trained in a passive (foot shock)avoidance task. When administered after training, the stimulants caffeine or nicotine blocked amnesia for the task that had been produced by injections of the protein synthesis inhibitor anisomycin given prior to training. With foot shock at a higher intensity, anisomycin did not produce amnesia by itself, but the administration of the depressants chloral hydrate or sodium phenobarbital after training did cause amnesia. Stimulants and depressants did not have an appreciable influence on the overall degree of protein synthesis inhibition produced by anisomycin. The results support the hypothesis that arousal after training is an important factor in the conversion of short-term to long-term memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flood, J F -- Bennett, E L -- Orme, A E -- Rosenzweig, M R -- Jarvik, M E -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):324-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619461" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anisomycin/*pharmacology ; Avoidance Learning/*drug effects ; Brain/*drug effects ; Caffeine/pharmacology ; Chloral Hydrate/pharmacology ; Drug Interactions ; Male ; Memory/*drug effects ; Mice ; Nerve Tissue Proteins/biosynthesis ; Nicotine/pharmacology ; Phenobarbital/pharmacology ; Pyrrolidines/*pharmacology
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  • 30
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    A nonpeptide morphine-like compound: immunocytochemical localization in the mouse brain (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-27
    Description: A nonpeptide morphine-like compound (MLC) which cross reacts with morphine-specific antibodies has been localized with the use of immunocytochemistry. This morphine-like compound is found in neuronal perikarya or processes (or both) in nuclei related to vestibular, cerebellar, and raphe systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gintzler, A R -- Gershon, M D -- Spector, S -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):447-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/339350" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Brain Chemistry ; Cerebellum/analysis ; Cerebral Aqueduct/analysis ; Cross Reactions ; Immunoenzyme Techniques ; Mice ; Morphine/*immunology ; Raphe Nuclei/analysis ; Vestibular Nuclei/analysis
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  • 31
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    Another flame retardant, tris-(1,3-dichloro-2-propyl)-phosphate, and its expected metabolites are mutagens (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: A flame retardant used in children's sleepwear, tris-(1,3-dichloro-2-propyl)phosphate (Fyrol FR2) is a mutagen in the Salmonella-mammalian tissue homogenate test after it has been activated by mouse or rat liver homogenate. The expected enzymatic hydrolysis product, 1,3-dichloro-2-propanol, is similarly a mutagen after activation by liver homogenate. A proposed metabolite of the flame retardant, 1,3-dichloro-2-propanone, is a potent mutagen in the absence of such activation. A flame retardant with similar structure, tris-(2,3-dibromopropyl)phosphate (tris-BP), was shown previously to be a mutagen, to cause sterility in animals, to be a carcinogen, and to be absorbed through human skin. These and other flame retardants have characteristic nuclear magnetic resonance spectra that can be used to determine which flame retardant is present in commercially purchased sleepwear. Sleepwear treated with tris-BP, Fyrol FR2, and other chemical additives was being sold in late 1977.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, M D -- Blum, A -- Ames, B N -- New York, N.Y. -- Science. 1978 May 19;200(4343):785-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347576" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotransformation ; Flame Retardants/*toxicity ; Hydrocarbons, Chlorinated/toxicity ; Liver/metabolism ; Mice ; *Mutagens ; Organophosphorus Compounds/*toxicity ; Salmonella typhimurium/drug effects ; Structure-Activity Relationship
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  • 32
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    Endosteal marrow: a rich source of hematopoietic stem cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: Hematopoietic cells isolated from the endosteal bone surface, that is,the endosteal marrow cells, were found to consist mainly (60 to 80 percent) of lymphoid and late-stage normoblast-like cells. Unlike the cells they resemble, the endosteal marrow cells showed an affinity for Sudan black, demonstrable nucleoli (Feulgen reaction), and an absence of hemoglobin. Assays showed that over one-half of the endosteal marrow cell population may be the colony-forming units, the CFU-S of Till and McCulloch. Thus, high concentrations of stem cells could be obtained from the endosteal bone surface by means of the present isolation technique.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gong, J K -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1443-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/75570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Cells ; Cell Nucleolus/ultrastructure ; Female ; Hematopoiesis ; Hematopoietic Stem Cells/*cytology ; Lymphocytes/ultrastructure ; Male ; Mice ; Rats ; Spleen/cytology ; Staining and Labeling
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  • 33
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    Retrograde amnesia produced by several treatments: evidence for a common neurobiological mechanism (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: This experiment examined the effects on memory of various amnestic treatments in animals earlier treated with the alpha-adrenergic antagonist phenoxybenzamine (PBZ). Thirty minutes before being trained in a one-trial inhibitory (passive) avoidance task, animals received an injection of PBZ or saline. Immediately after training, each animal received one of the following amnestic treatments: stimulation of the frontal cortex or amygdala, pentylenetetrazol, diethyldithiocarbamate, or cycloheximide. In control animals, each treatment produced retrograde amnesia. However, PBZ-treated animals did not develop amnesia. These findings suggest that there may be a common neurobiological mechanism underlying the amnesias produced by many treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, P E -- Sternberg, D B -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208153" target="_blank"〉PubMed〈/a〉
    Keywords: Amnesia/*etiology ; Amnesia, Retrograde/*etiology/prevention & control ; Amygdala/physiopathology ; Animals ; Avoidance Learning/drug effects ; Cerebral Cortex/physiopathology ; Cycloheximide/antagonists & inhibitors ; Ditiocarb/antagonists & inhibitors ; Electric Stimulation ; Humans ; Memory/*drug effects ; Mice ; Phenoxybenzamine/*pharmacology ; Rats ; Seizures/complications
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    Rod-cone dysplasia in Irish setters: a defect in cyclic GMP metabolism in visual cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: An abnormality in retinal guanosine 3,5-monophosphate (cyclic GMP) metabolism is demonstrated in the inherited rod-cone dysplasis of Irish Setter dogs. Affected visual cells are deficient in cyclic GMP phosphodiesterase activity and have elevated levels of cyclic GMP. The biochemical abnormalities observed in affected retinas of Irish Setters are similar to those in the retinas of mice with inherited retinal degeneration before visual cell degeneration begins. A defect in cyclic GMP metabolism may be characteristic of early-onset degenerative diseases of the retina, possibly including those that affect humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aquirre, G -- Farber, D -- Lolley, R -- Fletcher, R T -- Chader, G J -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1133-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210508" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-GMP Phosphodiesterases/*deficiency ; Animals ; Cell Differentiation ; Chromosome Aberrations/genetics/metabolism/pathology/veterinary ; Chromosome Disorders ; Cyclic GMP/*metabolism ; Dog Diseases/genetics/*metabolism/pathology ; Dogs ; Kinetics ; Mice ; Photoreceptor Cells/metabolism/pathology ; Retina/enzymology/*metabolism/pathology ; Retinal Degeneration/genetics/metabolism/pathology/*veterinary
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 35
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Shotgun collections of Charon 3A bacteriophages containing Eco RI fragments of human and mouse DNA were constructed with the use of in vitro packaging. Plaques were screened by hybridization, and globin-specific clones were isolated from both human (Charon 3AHs51.1) and mouse (Charon 3AMm30.5). The fragments cloned were detected in unfractionated genomic DNA by the Southern method of hybridization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blattner, F R -- Blechl, A E -- Denniston-Thompson, K -- Faber, H E -- Richards, J E -- Slightom, J L -- Tucker, P W -- Smithies, O -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1279-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725603" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coliphages/genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Fetal Hemoglobin/genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; Poly A ; Poly T
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  • 36
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    Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurland, J I -- Bockman, R S -- Broxmeyer, H E -- Moore, M A -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):552-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/304600" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells ; Cell Differentiation ; Cells, Cultured ; Colony-Stimulating Factors/*physiology ; Feedback ; Glycoproteins/*physiology ; Granulocytes/*cytology ; *Hematopoiesis ; Humans ; Leukocytes/*cytology ; Macrophages/cytology/*physiology ; Mice ; Models, Biological ; Monocytes/*physiology ; Prostaglandins E/*physiology
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  • 37
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    Enkephalin-containing neurons visualized in spinal cord cell cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: Neuronal cells, axons, and terminals containing immunoreactive enkephalin have been visualized in cultures of dissociated fetal spinal cord. These cultures may provide a valuable system in which to explore the effects of chronic drug treatment on the physiology of enkephalin-containing cells and their interactions with other cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neale, J H -- Barker, J L -- Uhl, G R -- Snyder, S H -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):467-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351811" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/metabolism ; Cells, Cultured ; Cytoplasm/metabolism ; Endorphins/*metabolism ; Enkephalins/*metabolism ; Fluorescent Antibody Technique ; Ganglia, Spinal/metabolism ; Mice ; Neurons/*metabolism ; Spinal Cord/cytology/embryology/*metabolism
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  • 38
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    Enhancement of conditioned arterial pressure responses in cats after brainstem lesions (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: Cats were classically conditioned after the baroreceptor reflexes were abolished by bilateral placement of electrolytic lesions in the nucleus tractus solitarii. The conditioned increases in arterial pressure were more than five times larger than the responses obtained in similarly trained controls. This finding suggests that the baroreceptor reflexes actively inhibit conditioned increases of arterial pressure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathan, M A -- Tucker, L W -- Serverini, W H -- Reis, D J -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663640" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Blood Pressure ; Cats ; Conditioning, Classical/physiology ; Disease Models, Animal ; Female ; Heart Rate ; Hypertension/physiopathology ; Male ; Medulla Oblongata/*physiology ; Pressoreceptors/*physiology ; Reflex/physiology
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  • 39
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    Frequency discrimination following the selective destruction of cochlear inner and outer hair cells (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-03-24
    Description: Frequency discrimination was measured behaviorally before and after drug-induced lesions of cochlear hair cells in the cat. Discrimination was unaffected by complete loss of outer hair cells provided that at least 50% of inner hair cells were intact. Thus, inner hair cells are important for frequency discrimination, and they can function normally in this regard without the influence of outer hair cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nienhuys, T G -- Clark, G M -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1356-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628846" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Threshold/physiology ; Behavior, Animal/physiology ; Cats ; Cochlea/ultrastructure ; Hair Cells, Auditory/drug effects/*physiology ; Kanamycin/pharmacology ; Mechanoreceptors/*physiology ; *Pitch Discrimination
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  • 40
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    Virus-induced diabetes mellitus: reovirus infection of pancreatic beta cells in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: Reovirus type 3, passaged in pancreatic beta-cell cultures, produced an insulitis when inoculated into 1- to 2-week-old mice. By means of a double-label antibody technique, in which we used fluorescein-labeled antibody to reovirus and rhodamine-labeled antibody to insulin, reovirus antigens were found in beta cells. By electron microscopy, viral particles in different stages of morphogenesis were observed in insulin-containing beta cells but not glucagon-containing alpha cells. The infection resulted in destruction of beta cells, reduction in the insulin content of the pancreas, and alteration in the host's capacity to respond normally to a glucose tolerance test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Onodera, T -- Jenson, A B -- Yoon, J W -- Notkins, A L -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):529-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208156" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Viral/analysis ; Cells, Cultured ; Diabetes Mellitus, Experimental/etiology/metabolism/*microbiology ; Diabetes Mellitus, Type 1/microbiology ; Insulin/metabolism ; Islets of Langerhans/metabolism/*microbiology ; Mammalian orthoreovirus 3/immunology ; Mice ; Reoviridae Infections/*complications ; Virus Replication
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  • 41
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    delta9-Tetrahydrocannabinol and 17beta-estradiol bind to different macromolecules in estrogen target tissues (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: delta9-Tetrahydrocannabinol (delta9-THC), added to the limit of its solubility, did not compete with tritiated 17beta-estradiol for binding to estrogen receptor sites in mouse mammary or uterine cytosols. On sucrose density gradients of low-ionic strength, mammary cytosol labeled with [3H]estradiol exhibited a binding peak near the "8S" region typical of estrogen receptor whereas in cytosol labeled with delta9-[3H]THC binding was limited to the nonspecific 4- to 5S region. Differences in sedimentation properties and reciprocal competition studies strongly refute previous claims that delta-9-THC binds to estrogen receptor and that by so doing it directly acts as an estrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okey, A B -- Bondy, G P -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):312-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635586" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Cytosol/metabolism ; Dronabinol/*metabolism ; Estradiol/*metabolism ; Female ; Mammary Glands, Animal/metabolism ; Mice ; Molecular Weight ; Receptors, Drug/*metabolism ; Receptors, Estrogen/isolation & purification/*metabolism ; Uterus/metabolism
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  • 42
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    Visualization of a guinea pig T lymphocyte surface component cross-reactive with immunoglobulin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-27
    Description: Thymus-derived lymphocytes (T cells) show exquisite specificity in recognition of antigens, but the nature of the cell surface receptor is controversial. Although antigen recognition mediated by immunoglobulin variable (V) regions remains the minimal hypothesis, it has been extremely difficult to definitely establish the presence of immunoglobulins on these cells. Chicken antibodies, produced against the (Fab')2fragment of mouse immunoglobulin G (IgG) and purified by binding to and elution from IgG-Sepharose 4B, bind to an endogenously synthesized surface component of guinea pig T cells. The binding occurred via a cross-reaction with murine k chain and a heavy chain determinant localized in the Fd region, and was visualized by immunofluorescence and immunoelectronmicroscopy using both transmission and scanning techniques. These data provide direct evidence for the presence of a surface component related to immunoglobulin on T lymphocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marchalonis, J J -- Bucana, C -- Hoyer, L -- Warr, G W -- Hanna, M G Jr -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):433-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/74094" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cross Reactions ; Epitopes ; Guinea Pigs ; Immunoglobulin Fab Fragments ; Immunoglobulin G ; Immunologic Techniques ; Mice ; Receptors, Antigen, B-Cell/*analysis ; Rosette Formation ; Species Specificity ; T-Lymphocytes/*immunology ; Thymus Gland/immunology
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  • 43
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    beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa) (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Margules, D L -- Moisset, B -- Lewis, M J -- Shibuya, H -- Pert, C B -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):988-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Eating/drug effects ; Endorphins/antagonists & inhibitors/blood/*physiology ; Feeding Behavior/*physiology ; Female ; Male ; Mice ; Mice, Obese/*physiology ; Naloxone/pharmacology ; Obesity/genetics/*physiopathology ; Pituitary Gland/physiology ; Rats
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  • 44
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    Ultraviolet radiation--induced chromosomal abnormalities in fetal fibroblasts from New Zealand black mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-08
    Description: Fibroblasts from New Zealand Black mouse fetuses manifest increased frequency of chromosomal breaks and interchanges after exposure to ultraviolet radiation when compared with cells from BABL/c fetuses. This chromosomal instability is similar to what has been reported in cells from patients with xeroderma pigmentosum and may be related to the chromosomally abnormal clones and malignancy previously reported in adult New Zealand Black mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, A L -- Fialkow, P G -- Salo, A -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):920-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; *Chromosome Aberrations ; Chromosomes/*radiation effects ; Disease Models, Animal ; Dose-Response Relationship, Radiation ; Mice ; Mice, Inbred BALB C/physiology ; Mice, Inbred NZB/*physiology ; *Ultraviolet Rays ; Xeroderma Pigmentosum/physiopathology
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  • 45
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    Ponto-geniculo-occipital (PGO) burst neurons: correlative evidence for neuronal generators of PGO waves (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-21
    Description: A newly discovered class of neurons, ponto-geniculo-occipital (PGO) burst neurons, has PGO wave relationships of phase-leading, stereotyped discharge bursts, and the highest reported discharge specificity and coherence; these neurons thus fulfill correlative criteria for output generator neurons for PGO waves. The PGO burst neurons are recorded in a discrete dorsal brainstem area in apposition to the brachium conjunctivum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCarley, R W -- Nelson, J P -- Hobson, J A -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):269-72.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663656" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Brain Stem/cytology/*physiology ; Cats ; Geniculate Bodies/*physiology ; Neural Conduction ; Neural Pathways/physiology ; Occipital Lobe/*physiology ; Pons/*physiology ; Sleep/physiology
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  • 46
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    The LDH virus: an interfering biological contaminant (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, V -- Spackman, D H -- Santisteban, G A -- Dalldorf, G -- Hellstrom, I -- Hellstrom, K E -- Lance, E M -- Rowson, K E -- Mahy, B W -- Alexander, P -- Stock, C C -- Sjogren, H O -- Hollander, V P -- Horzinek, M C -- New York, N.Y. -- Science. 1978 Apr 14;200(4338):124-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/263259" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Lactate dehydrogenase-elevating virus ; Mice ; Neoplasm Transplantation ; Neoplasms, Experimental/microbiology ; Virus Diseases/microbiology
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  • 47
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    6-Mercaptopurine treatment of pregnant mice: effects on second and third generations (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-07-07
    Description: The immunosuppressive drug 6-mercaptopurine is embryotoxic in mice. Of the surviving female offspring of mice treated with low doses of 6-mercaptopurine during pregnancy, despite normal body weight and general appearance, many were either sterile or, if they became pregnant, had smaller litters and more dead fetuses as compared to offspring of mothers that had not received the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reimers, T J -- Sluss, P M -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663638" target="_blank"〉PubMed〈/a〉
    Keywords: 6-Mercaptopurine/*pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Fetal Death/*chemically induced ; Fetus/drug effects ; Germ Cells/*drug effects ; Infertility, Female/*chemically induced ; Litter Size/drug effects ; Mice ; Ovary/cytology/drug effects/embryology ; Pregnancy ; Pregnancy, Animal/*drug effects
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  • 48
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    Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3',5'-monophosphate (cyclic GMP) by these cells. Receptor agonists for H1, but not H2, caused this effect which was reduced by H1 but not by H2 or muscarinic acetylcholine receptor antagonists. These results indicate that activation of H1 receptors in these cultured nerve cells stimulated cyclic GMP formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richelson, E -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26974" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/pharmacology ; Carbachol/pharmacology ; Cell Line ; Cyclic GMP/*metabolism ; Histamine/*pharmacology ; Histamine H1 Antagonists/pharmacology ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Receptors, Histamine/*drug effects ; Receptors, Histamine H1/*drug effects
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  • 49
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    Morphological alterations in hippocampus after long-term alcohol consumption in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: Golgi methods were used to examine the hippocampus of laboratory mice that received alcohol-containing or control diets for 4 months followed by a 2-month alcohol-free period. Long-term alcohol consumption resulted in a significant loss of dendritic spines on hippocampal pyramidal cells and dentate granule cells. This study provides evidence that long-term alcohol consumption, in the absence of malnutrition, produces morphological damage to the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, J N -- Walker, D W -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):646-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566953" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/*pathology ; Animals ; Dendrites/ultrastructure ; *Disease Models, Animal ; Female ; Hippocampus/*pathology ; Humans ; Mice ; Pyramidal Tracts/pathology
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  • 50
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    Membrane potentials of mitochondria (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rottenberg, H -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):568-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622562" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Energy Metabolism ; *Membrane Potentials/drug effects ; Mice ; Microelectrodes ; Mitochondria/*physiology ; Valinomycin/pharmacology
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  • 51
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    Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: 2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schaumburg, H H -- Spencer, P S -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):199-200.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/413192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/pathology ; Cats ; Environmental Pollutants/*toxicity ; Geniculate Bodies/drug effects ; Hexanones/*toxicity ; Ketones/*toxicity ; Mammillary Bodies/*drug effects/pathology ; Nerve Degeneration/*drug effects ; Superior Colliculi/pathology ; Visual Pathways/*drug effects/pathology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Prevention of death from metastases by immune RNA therapy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: The effect of immune RNA treatment on the incidence of death from pulmonary metastases was studied in C57BL/6J mice after excision of a B16 murine melanoma. Immune RNA was extracted from the lymphoid tissues of guinea pigs immunized with B16 tumor and then incubated in vitro with normal C57BL/6J mouse splenocytes. Mice receiving intraperitoneal injections of these RNA-treated syngeneic splenocytes after the primary B16 isograft was resectioned showed significantly improved long-term survival (42 to 67 percent in three successive experiments) as compared to control mice (0 to 20 percent survival) receiving untreated splenocytes. The effect of RNA treatment was tumor-specific and ribonuclease sensitive. The results suggest that immunotherapy with immune RNA may be of benefit to certain patients after surgery for cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, B S -- Onikul, S R -- Mannick, J A -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):59-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694519" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Immunotherapy/methods ; Lung Neoplasms/prevention & control ; Lymphocytes/*immunology ; Melanoma/immunology ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis/*prevention & control ; Neoplasms, Experimental/immunology ; RNA/immunology/*therapeutic use ; Spleen/immunology
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    Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: The adenosine 3',5'-monophosphate (cyclic AMP) levels of mouse lymphocytes rose and fell sharply 10 hours after stimulation with concanavalin A. Treatment of the cells with indomethacin reversibly prevented the increase in cyclic AMP and the subsequent onset of DNA synthesis. When the heightened cyclic AMP before S phase was maintained by either inhibiting phosphodiesterase or by adding the 8-bromo derivative of cyclic AMP, DNA synthesis was also blocked. Both the increase and decrease in cyclic AMP appear to be required for progression of lymphocytes into the S phase of growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, T -- Sheppard, J R -- Foker, J E -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):155-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208147" target="_blank"〉PubMed〈/a〉
    Keywords: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacology ; Animals ; Cell Cycle/drug effects ; *Cell Division/drug effects ; Concanavalin A/antagonists & inhibitors ; Cyclic AMP/analogs & derivatives/*metabolism/pharmacology ; DNA/*biosynthesis ; Indomethacin/pharmacology ; *Lymphocyte Activation/drug effects ; Lymphocytes/*metabolism ; Mice ; RNA/biosynthesis ; Spleen/cytology
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    Genetic mapping of xenotropic leukemia virus-inducing loci in two mouse strains (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: In genetic studies of C57BL/10 and BALB/c mice, inducibility of xenotropic murine leukemia virus from tissue cultures by treatment with 5-iododeoxyuridine shows single gene segregation ratios. In both strains, the virus-inducing loci are on chromosome 1, linked to the Dip-1/isozyme locus, but the two may not be at allelic sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kozak, C -- Rowe, W P -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1448-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Genes ; Genetic Linkage ; Idoxuridine/pharmacology ; Leukemia Virus, Murine/*genetics ; Mice ; Mice, Inbred BALB C/*genetics ; Mice, Inbred C57BL/*genetics ; *Virus Replication/drug effects
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    Binding of benzo[a]pyrene 7,8-diol-9,10-epoxides to DNA, RNA, and protein of mouse skin occurs with high stereoselectivity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: The formation, stereostructure, and cellular reactions of the 7,8-diol-9,10-epoxide metabolites of the carcinogen benzo[a]pyrene have been examined after topical application of benzo[a]pyrene to the skin of mice. In this known target tissue, polymer adducts from diastereomeric diol epoxides, (+)-(7S, 8R, 9R, 10R) and (+)-(7R, 8S, 9R, 10R), were formed stereospecifically from their corresponding 7,8-dihydrodiols. Both diol epoxides bind with proteins, RNA, and DNA in vivo. For the nucleic acids, binding occurs preferentially at the 2-amino group of guanine in cellular RNA and DNA in vivo. Methods for establishing the structure of the cellular adducts as well as the possible biological implications of their formation are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koreeda, M -- Moore, P D -- Wislocki, P G -- Levin, W -- Yagi, H -- Jerina, D M -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):778-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622566" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzopyrenes/*metabolism ; Chromatography, High Pressure Liquid ; DNA/*metabolism ; Epoxy Compounds/metabolism ; Female ; Mice ; Mice, Inbred C57BL ; Molecular Conformation ; Proteins/*metabolism ; RNA/*metabolism ; Skin/*metabolism ; Stereoisomerism
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    Intracellular analysis of trigeminal motoneuron activity during sleep in the cat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: Intracellular recordings were made from trigeminal motoneurons of normally respiring, unanesthetized cats during naturally occurring sleep. The transition from quiet to active sleep was accompanied by tonic motoneuron hyperpolarization. Stimulation of the reticular formation induced a depolarizing potential in trigeminal motoneurons during quiet sleep and a hyperpolarizing potential during active sleep. The results provide a synaptic explanation for the phenomenon of reticular response reversal and insights into the basic mechanisms controlling motor activity during the sleep states.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakamura, Y -- Goldberg, L J -- Chandler, S H -- Chase, M H -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):204-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/202025" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Electric Stimulation ; Membrane Potentials ; Motor Neurons/*physiology ; Reflex ; Reticular Formation/*physiology ; Sleep/*physiology ; Sleep, REM/physiology ; Synapses/physiology ; Trigeminal Nerve/*physiology
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    Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: Prostacyclin, a potent, naturally occurring prostaglandin exerts a variety of cardiovascular and cellular actions of potential value in acute myocardial ischemia. These properties include the reduction of systemic blood pressure without changing heart rate, the lowering of coronary vascular and total peripheral resistance, the inhibition of platelet aggregation and the concomitant formation of thromboxane B2, and the reduction of the release of lysosomal enzymes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lefer, A M -- Ogletree, M L -- Smith, J B -- Silver, M J -- Nicolaou, K C -- Barnette, W E -- Gasic, G P -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):52-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/345441" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/drug effects ; Cats ; Coronary Circulation/drug effects ; Coronary Disease/drug therapy ; Epoprostenol/*pharmacology/therapeutic use ; Heart Rate/drug effects ; Hemodynamics/*drug effects ; In Vitro Techniques ; Lysosomes/drug effects/enzymology ; Myocardial Contraction/drug effects ; Platelet Aggregation/drug effects ; Prostaglandins/*pharmacology ; Thromboxanes/blood ; Vascular Resistance/drug effects
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    Chick embryonic skin as a rapid organ culture assay for cellular neoplasia (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: We used chick embryonic skin (CES) in organ culture to assess the neoplastic potential of a variety of cultured human and nonhuman cell lines. Cells derived from cancer tissues grew in CES and formed tumors in nude mice while cells derived from normal tissues grew in neither system. The CES proved to be more sensitive than the nude mouse when used to assay SV40 transformed human cells; each of four such lines grew in CES while only one of the four lines grew and formed tumors in nude mice. In addition, the patterns of invasion by inoculated cells can be easily studied in the CES. These results suggest that CES in organ culture offers an inexpensive, rapid, and reliable alternative to the nude mouse as a tumorigenicity test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noguchi, P D -- Johnson, J B -- O'Donnell, R -- Petricciani, J C -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):980-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Line ; Cell Survival ; *Cell Transformation, Neoplastic ; *Chick Embryo/metabolism ; Mice ; Mice, Nude ; Mitosis ; Neoplasm Invasiveness ; Neoplasms/*metabolism/pathology ; *Organ Culture Techniques ; Simian virus 40 ; Skin/*embryology/metabolism/pathology
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    Switch in immunoglobulin class production observed in single clones of committed lymphocytes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-10
    Description: Mouse spleen cells, after stimulation with lipopolysaccharide, were cloned in culture. After 4 to 5 days, the daughter cells were stained and examined for immunoglobulin class with double immunofluorescent reagents. A switch of the stained color of these cells was observed, implying a switch from imunoglobulin M to immunoglobulin G production in the progeny of a single B cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wabl, M R -- Forni, L -- Loor, F -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1078-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/305113" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*immunology ; Cells, Cultured ; Clone Cells/immunology ; Cytoplasm/immunology ; Immunoglobulin Fc Fragments ; Immunoglobulin G/*biosynthesis ; Immunoglobulin M/*biosynthesis ; Mice ; Receptors, Antigen, B-Cell/biosynthesis ; Spleen/immunology
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    A harvester ant venom: chemistry and pharmacology (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-02
    Description: The mammalian toxicity of the potently algogenic venom of the ant Pogonomyrmex badius is greater than that reported for any other insect venom. This enzyme-rich venom contains high concentrations of phospholipase A2 and B, hyaluronidase, acid phosphatase, lipase, and esterases. This hemolytic secretion from the poison gland products unusual symptoms in mammals and appears to have been evolved as a deterrent for vertebrate predators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, J O -- Blum, M S -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1064-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653354" target="_blank"〉PubMed〈/a〉
    Keywords: Acid Phosphatase/metabolism ; Animals ; Ant Venoms/analysis/*toxicity ; Arthropod Venoms/*toxicity ; Esterases/metabolism ; Hemolysin Proteins/*analysis ; Heparin/pharmacology ; Hyaluronoglucosaminidase/metabolism ; Lethal Dose 50 ; Lipase/metabolism ; Mice ; Phospholipases/metabolism
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    Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: Exogenously added prostaglandins E1 and E2, but not F2alpha, inhibited the tumoricidal activity of interferon-activated macrophages of mice. A role for adenosine 3',5'-monophosphate (cyclic AMP) in modulating macrophage functional activity was suggested because prostaglandins of the E series increase intracellular concentrations of cyclic AMP in macrophages and because treatment of interferon-activated macrophages with dibutyryl cyclic AMP consistently inhibits expression of cytotoxicity. Since the activated macrophage releases high concentrations of prostaglandin E2, it is postulated that this prostaglandin could act locally in negative feedback inhibition to limit cell activities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schultz, R M -- Pavlidis, N A -- Stylos, W A -- Chirigos, M A -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cytotoxicity, Immunologic/drug effects ; Immunity, Cellular/*drug effects ; Interferons/*antagonists & inhibitors ; Macrophages/*immunology ; Male ; Mice ; Neoplasms, Experimental/*immunology ; Nucleotides, Cyclic/pharmacology ; Prostaglandins E/*pharmacology ; Prostaglandins F/pharmacology
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    L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. Since melanocytes arise from the neural crest embryologically, the effect of L-dopa methyl ester, a soluble analog, on the murine C1300 neuroblastoma was studied. There was significant antitumor activity against the neuroblastoma, which was enhanced by combination with a dopa decarboxylase inhibitor, Ro4-4602. In vitro studies suggested inhibition of DNA synthesis as the principal site of action. A mechanism involving sulfhydryl compound scavenging is postulated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wick, M M -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):775-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622565" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benserazide/pharmacology ; Cell Line ; Drug Synergism ; Leucine/metabolism ; Levodopa/*analogs & derivatives/pharmacology/therapeutic use ; Male ; Mice ; Neoplasms, Experimental/drug therapy/metabolism ; Neuroblastoma/*drug therapy/metabolism ; Thymidine/metabolism ; Uridine/metabolism
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    Ah locus: genetic differences in susceptibility to cataracts induced by acetaminophen (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: The Ahb/Ahb homozygous and the Ahb/Ahd heterozygous inbred mouse strains from the (C57BL/6)(DBA/2)F1 X DBA/2 backcross are genetically responsive to 3-methylcholanthrene. They both also develop, within 6 hours after a large intraperitoneal dose of acetaminophen, an irreversible opacity in the anterior portion of the lens. Such cataract formation does not occur in similarly treated nonresponsive inbred strains or nonresponsive Ahd/Ahd individuals from the same backcross. Differences in acetaminophen metabolism and toxicity are associated with the Ah locus in the mouse, and differences in heritability at the Ah locus exist in the human. Our ophthalmologic findings may be important clinically to certain patients receiving either a single large overdose of this drug or high doses over a long period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shichi, H -- Gaasterland, D E -- Jensen, N M -- Nebert, D W -- New York, N.Y. -- Science. 1978 May 5;200(4341):539-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644313" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaminophen ; Animals ; Aryl Hydrocarbon Hydroxylases/biosynthesis/*genetics ; Cataract/chemically induced/*genetics ; Enzyme Induction ; Methylcholanthrene ; Mice ; Mice, Inbred Strains
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    Hepatic fibrosis in schistosomiasis: egg granulomas secrete fibroblast stimulating factor in vitro (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-27
    Description: Cytosol extracts and culture supernatants of isolated egg granulomas obtained from livers of mice with Schistosoma mansoni infection stimulated fibroblasts to incorporate tritiated thymidine and to proliferate in vitro. This finding suggests that hepatic granulomas may play a role in regulating hepatic fibrosis in Schistosoma mansoni infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyler, D J -- Wahl, S M -- Wahl, L M -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):438-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705337" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Fibroblasts/pathology ; Granuloma/complications/*etiology/metabolism ; Growth Substances/*secretion ; Inflammation/physiopathology ; Liver Cirrhosis/*etiology ; Mice ; Schistosoma mansoni ; Schistosomiasis/complications/*pathology/physiopathology
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Two globin-related clones isolated from collections of bacteriophages containing unfractionated Eco RI fragments of human and mouse DNA were characterized. Charon3AHs51.1Hbgamma includes 2.7 kilobase pairs of human DNA containing a large part of a fetal gamma globin chain structural gene; Charon 3AMm30.5 includes 4.7 kilobase pairs of mouse DNA related to alpha globin. The human fetal gamma globin gene has within its coding region two intervening sequences of noncoding DNA, IVS 1 and IVS 2, of approximately 1-0 and 900 base pairs. Sequence IVS 1 is located at the position of one of the two intervening sequences occurring in adult globin genes; IVS 2 is located at the position of the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smithies, O -- Blechl, A E -- Denniston-Thompson, K -- Newell, N -- Richards, J E -- Slightom, J L -- Tucker, P W -- Blattner, F R -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1284-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725604" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Codon ; DNA Restriction Enzymes/metabolism ; DNA, Recombinant ; Fetal Hemoglobin/*genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; RNA, Messenger/genetics
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    Biochemical evidence for keratinization by mouse epidermal cells in culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-30
    Description: More than 70 percent of the urea-extractable proteins from mouse stratum corneum or from differentiated cells of mouse epidermis grown in culture are two proteins of molecular weight 68,000 (keratin I) and 60,000 (kerae are two proteins of molecular weight 68,000 (keratin 1) and 60,000 (keratin 2), which are present in equimolar amounts on polyacrylamide gels. These proteins are the subunits of the keratin filaments, because when isolated from stratum corneum or cells grown in culture they form native-type epidermal keratin filaments in vitro. These observations provide biochemical evidence that epidermal cells grown in culture synthesize the major differentiation products of the epidermis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinert, P -- Yuspa, S H -- New York, N.Y. -- Science. 1978 Jun 30;200(4349):1491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566466" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cells, Cultured/metabolism ; Epidermis/cytology/*metabolism/ultrastructure ; Keratins/*metabolism ; Mice ; Molecular Weight
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    Effect of myasthenic immunoglobulin on acetylcholine receptors of intact mammalian neuromuscular junctions (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-16
    Description: Degradation of acetylcholine receptors of intact mouse neuromuscular junctions was determined in vivo and in vitro by the release of radioactivity from mouse diaphragms labeled with 125I-alpha-bungarotoxin. Treatment of mice with immunoglobulin from myasthenic patients accelerated the degradation rate to approximately three times normal, in both intact animals and organ cultures. The released radioactivity was in the form of [125I]tyrosine, confirming the nature of the degradative process. Accelerated degradation of acetylcholine receptors at neuromuscular junctions may represent an important antibody-mediated mechanisms in myasthenia gravis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, E F -- Drachman, D B -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1285-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Reactions ; *Autoantibodies ; Bungarotoxins/metabolism ; Diaphragm ; Humans ; Mice ; Myasthenia Gravis/*immunology/metabolism ; Neuromuscular Junction/*metabolism ; Receptors, Cholinergic/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 68
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    Prostaglandin restoration of the interferon response of hyporeactive animals (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: Virus-infected animals and those bearing various types of malignancies progressively lose the ability to respond to interferon inducers. The interferon response of virus-infected animals could be restored to normal levels when inducers were administered with certain prostaglandins. This suggests that prostaglandins may enhance the therapeutic efficacy of interferon inducers as antiviral and antineoplastic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stringfellow, D A -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):376-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208154" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascitic Fluid/cytology ; Encephalomyocarditis virus ; Exudates and Transudates/metabolism ; Friend murine leukemia virus ; Influenza A virus ; Interferon Inducers/*pharmacology ; Interferons/*biosynthesis ; Leukemia, Experimental/physiopathology ; Mice ; Newcastle disease virus ; Prostaglandins/*pharmacology ; Semliki forest virus ; Virus Diseases/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 69
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    Exponential decrease during aging and random lifetime of mouse spermatogonial stem cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: Variation in the number of spermatogonial stem cells during the lifespan of the mouse was examined by assaying the number of clonogenic cells, that is, spermatogenic stem cells, surviving known doses of radiation. The results indicated that the stem cell number decreased exponentially with age.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suzuki, N -- Withers, H R -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1214-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725597" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Dose-Response Relationship, Radiation ; Gamma Rays ; Male ; Mice ; Spermatogonia/*cytology ; Spermatozoa/*cytology ; Testis/*cytology/radiation effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 70
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    Brain noradrenergic systems as a prerequisite for developing tolerance to barbiturates (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: Mice treated with 6-hydroxydopamine before they were chronically fed phenobarbital did not develop functional barbiturate tolerance, measured by duration of the loss of righting reflex and hypothermia. Injection of 6-hydroxydopamine caused significant depletion of brain norepinephrine, while brain dopamine levels were not significantly depleted. Intact brain noradrenergic systems seem to be necessary for developing tolerance to the hypnotic and hypothermic effects of the barbiturates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tabakoff, B -- Yanai, J -- Ritzmann, R F -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):449-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/565533" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Body Temperature Regulation/drug effects ; Brain/*drug effects ; Drug Tolerance ; Humans ; Hydroxydopamines/pharmacology ; Male ; Mice ; Norepinephrine/*metabolism ; Phenobarbital/*pharmacology ; Reflex/drug effects ; Substance Withdrawal Syndrome/physiopathology ; Substance-Related Disorders/physiopathology ; Sympathetic Nervous System/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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