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  • Springer  (107,355)
  • 2010-2014
  • 1980-1984  (86,786)
  • 1960-1964  (20,569)
  • 1925-1929
  • 1982  (44,622)
  • 1980  (42,164)
  • 1964  (20,569)
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  • 2010-2014
  • 1980-1984  (86,786)
  • 1960-1964  (20,569)
  • 1925-1929
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  • 1
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    Bulletin of mathematical biology 26 (1964), S. 1-7 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract In the arteries, blood flow and blood pressure are pulsatile in nature (Roston, 1962a; Roston 1962b). The patterns of blood movement and mural distension in the arteries are important because they may be associated with life-threatening degenerative changes in the arterial walls. As the vascular channels narrow, the pulsation decreases. At the level of the capillaries, almost no pulsation exists (Best and Taylor, 1961). The tissues are affected by the direct flow in the capillaries and not by the pulsation in the arteries. Thus, such quantities as pulse pressure, systolic pressure, and diastolic pressure which characterize blood movement in the arteries are not important as far as the tissues are concerned. Rather, the average pressure and flow in the capillaries are the quantities significant for tissue blood flow. The present study analyzes the local blood circulation in a typical tissue. Logical extension of this analysis results in insights into the physiological behavior of the circulation which integrate a considerable body of experimental data.
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    Bulletin of mathematical biology 42 (1980), S. 131-135 
    ISSN: 1522-9602
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    Notes: Abstract The theory of complementary variational principles is used to obtain maximum and minimum principles for diffusion problems with Michaelis-Menten kinetics. In an illustrative calculation we obtain an extremely accurate variational solution in good agreement with the numerical solution of McElwain (1978).
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    Bulletin of mathematical biology 42 (1980), S. 137-141 
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    Bulletin of mathematical biology 42 (1980), S. 181-189 
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    Notes: Abstract Necessary and sufficient conditions for primitivity of a product of two Leslie matrices are given. Such a product could be used in modeling the growth of a population governed alternately by two different sets of fertility and survival parameters.
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    Bulletin of mathematical biology 42 (1980), S. 173-180 
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    Notes: Abstract Zadeh's transfer function method for linear time-variable systems is used to apply frequency-domain analysis to a periodically time-varying elastance model of the left ventricle. Left ventricular pressure computed from the system function of the time-varying elastance and the phasors of aortic flow shows a typical waveform of the measured ventricular pressure.
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    Bulletin of mathematical biology 42 (1980), S. 901-901 
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    Bulletin of mathematical biology 44 (1982), S. 1-15 
    ISSN: 1522-9602
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    Notes: Abstract A theorem is proved, concerning expected values of a multitype branching process in a varying environment. The consequence of the theorem is that the branching process can be treated (in the sense of expected values) as a dynamical system with control terms. This is of importance in situations where the process serves as an abstract model of the dynamics of malignant cells for use in chemotherapy. A simple example of this kind is given.
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    Bulletin of mathematical biology 44 (1982), S. 29-42 
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    Notes: Abstract A method is developed for a full nonlinear evaluation of all velocities and stresses represented in the Navier-Stokes equations and in the general stress tensor. The information required is essentially that for solution of linearized forms. The solution is analytical except for the calculation of the axial velocity, which requires computer assistance to step through time and space. The treatment of the problem, although directed towards solutions involving fluid flow in elastic vessels, is also adaptable to solid deformations (strain vs rate of strain) where the general stress tensor applies. A special case for the distorting ellipse is presented as well as a limited, spatially analytic, solution.
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    Bulletin of mathematical biology 44 (1982), S. 43-56 
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    Notes: Abstract The stability characteristics and dynamical behavior of a system of mutually excitatory neurons in close spatial proximity are investigated with a mathematical model. The model predicts the existence of uniform, intermediate levels of activity other than those of no activity and maximal activity. The model also, yeilds a good explanation of data obtained from periglomerular neurons in the olfactory bulb of the cat.
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    Bulletin of mathematical biology 44 (1982), S. 75-86 
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    Notes: Abstract A multicompartmental model in which particles enter the system from the environment and reproduce according to a Markov branching process has been considered. Explicit expressions have been obtained for the mean vector and the correlation structure for the numbers of particles in different compartments in different time points of the system. Growth rates of the mean vector and some special cases of the system are also discussed.
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    Bulletin of mathematical biology 44 (1982), S. 57-74 
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    Notes: Abstract The study of bi-directionally coupled oscillators is relevant in biological modelling of such systems as gastro-intestinal electrical activity, cardiac pacemarkers, cardiovascular and respiratory interactions and circadian rhythms. Interconnecting pathways in biological systems often exhibit pure time-delay characteristics. In this paper the multiple-mode limit-cycle behaviour of such systems is analysed using the method of harmonic blance. It is shown that the coupling time delay radically affects the number, frequency and amplitudes of entrained limit-cycles.
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    Bulletin of mathematical biology 44 (1982), S. 87-102 
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    Notes: Abstract The effect of keeping all the parameters constant, except the diffusion coefficients, in a pair of reaction-diffusion equations is studied. It is shown that the stability of the constant solution and the bifurcation points can be easily established by constructing a simple stability diagram. The possible qualitatively different diagrams are enumerated.
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    Bulletin of mathematical biology 44 (1982), S. 103-117 
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    Notes: Abstract We have numerically examined more than one million Large Complex Systems (LCS) of interacting variables (interpretable as interacting populations) governed by Generalized Lotka-Volterra Equations (GLV), with self-regulation term. The scope was to have some insight on the stability-complexity relationship. We considered systems of prey-predator type, and we gave appropriate rules for constructing the model systems, rules that specify the behaviour of model systems in order to put them near the biological reality. The results show, among other things, a strict correlation between the stability and the prey-predator ratio (which, in our model, uniquely determines the connectedness of the system).
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    Bulletin of mathematical biology 44 (1982), S. 149-150 
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    Bulletin of mathematical biology 44 (1982), S. 119-134 
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    Notes: Abstract The rate-controlling process in the oxygenation of red blood cells is investigated using a Roughton-like model for oxygen diffusion and reaction with hemoglobin. The mathematical equations describing the model are solved using two independent techniques, numerical inversions of the Laplace transform of the equations and numerical solutions via an implicit-explicit finite difference form of the equations. The model is used to re-examine previous theoretical models that incorporate either a red cell membrane that is resistive to oxygen diffusion or an unstirred layer of water surrounding the cell. Although both models have been postulated to be equivalent, the results of the computer simulations demonstrate significant differences between the two models in the rate of oxygenation of the red cells, depending upon the values chosen for the diffusion coefficient for O2 in the membrane and the thickness of the water layer. The difference is apparently due to differences in the induction and transient periods of the water layer model relative to the membrane model.
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    Bulletin of mathematical biology 44 (1982), S. 537-547 
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    Notes: Abstract We examine certain mathematical structures presented in Part I. The most important of these are the energy structures determined by the couple (ω×E, ψ) the space of causality defined by ψ-1(0) and the notion of collapsibility, i.e., the descent of a species from a higher to a lower equilibrium configuration as a result of energy loss.
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    Bulletin of mathematical biology 44 (1982), S. 557-570 
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    Notes: Abstract This paper discusses a general stochastic model for a two-compartment reversible system with non-homogeneous Poisson inputs, arbitrary residence times at each of the compartments and time-dependent transition probabilities. The probability distributions of the number of particles in each compartment and in the system are obtained together with the number of particles which depart from the system. In addition, various covariance functions with a time lag are obtained. Some of the above obtained results are deduced for time-independent arrivals, exponential residence times and time-independent transition probabilities. Fluctuations of the particles present in the system are also analysed. Similar analysis is provided for the model into which some particles are initially introduced at the system. Some possible applications are discussed at the end.
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    Bulletin of mathematical biology 44 (1982), S. 571-578 
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    Notes: Abstract The general multispecies prey-predator system with Gompertz's antisymmetric interactions is nonlinearly stable in the absence of dispersion and continues to remain stable with dispersion under both homogeneous reservoir and zero flux boundary conditions in a region containing the equilibrium state. It is proved that a general multispecies food-web model without antisymmetric interactions is stable in the absence of dispersion and remains stable with dispersion in the above-mentioned region.
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    Bulletin of mathematical biology 44 (1982), S. 593-593 
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    Bulletin of mathematical biology 44 (1982), S. 579-585 
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    Notes: Abstract We introduce a graphical approach in the study of the qualitative behavior ofm species predator-prey systems. We prove that tree graphs imply global stability for Volterra models and local stability for general models; furthermore, we derive sufficient conditions so that loop graphs imply stability and boundedness of the solutions.
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    Bulletin of mathematical biology 44 (1982), S. 594-595 
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    Bulletin of mathematical biology 44 (1982), S. 731-739 
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    Notes: Abstract A system of integro-differential equations is derived to describe epizootics of a fungal pathogen in an insect population. Because of piecewise continuous behavior under some parametric conditions, it is concluded that standard phase orbits can be misleading. Using a different analytic approach yields a simple system of finite difference equations. Both the continuous and discrete versions are compared to classical forms. The continuous version differs from a classical one in possessing a second derivative dependent on population density. The discrete version differs in maintaining positive, non-zero populations of both infectives and susceptibles in finite time.
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    Bulletin of mathematical biology 44 (1982), S. 741-748 
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    Notes: Abstract This note is an attempt to demonstrate that hypothalamic pulsatile GnRH secretion is not the result of a short-term, negative steroid hormone feedback. Clarification of this point is of importance for further modelling the control of gonads.
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    Bulletin of mathematical biology 44 (1982), S. 749-760 
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    Notes: Abstract A modern theory of the calculus of variations is used to form necessary and sufficient conditions for the existence of a Lagrangian representation of a system of first-order ordinary differential equations. There exists a theorem to the effect that when a system of ordinary differential equations is variationally self-adjoint, the fulfillment of such conditions is guaranteed. In addition, self-adjointness, allows establishement of an algorithm by which a Lagrangian for the system may be explicitly constructed. Examples in mathematical biology are given to illustrate the use of the stated theorem.
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    Bulletin of mathematical biology 44 (1982), S. 793-808 
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    Notes: Abstract Engineering optimal control theory is applied to equations describing insulin and glucose interactions. The nature of the optimal controller is established. It is shown how the results can be utilized in a closed loop feedback control system.
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    Bulletin of mathematical biology 44 (1982), S. 777-791 
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    Notes: Abstract An attempt is made to compare the conditions for the general error-optimality of linear systems developed by Kalman with the conditions for feasibility of linear models of neuromuscular and physiological control systems. Models of three actual physiological systems are tested for both the above criteria. Theoretical analysis presented here shows that there are no simple relationships between the two sets of conditions. Analysis carried out on the physiological systems models suggests the need for a general set of conditions for other optimality criteria, such as time and energy minimization, similar to Kalman's condition for error minimization.
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    Bulletin of mathematical biology 44 (1982), S. 851-877 
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    Notes: Abstract Following arteriolar occlusion, tissue oxygen concentration decreases and anoxic tissue eventually develops. Although anoxia first appears in the region most distal to the capillary at the venous end, it eventually spreads throughout the entire region of supply. In this paper the changing oxygen concentration, from the time of occlusion until the tissue is entirely anoxic, is examined mathematically. The equations governing oxygen transport to tissue are solved by iterating a nonlinear integral equation. This solution is valid until anoxia first appears. After anoxia develops it is necessary to solve a moving boundary problem. This is done using the method of matched asymptotic expansions, and accurate solutions are obtained for a wide range of physiological conditions.
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    Bulletin of mathematical biology 44 (1982), S. 899-900 
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    Circuits, systems and signal processing 1 (1982), S. 93-104 
    ISSN: 1531-5878
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    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract A stochastic approximation problem for polynomic operators is formulated. The performance of polynomic operators of various degrees is compared. The effect of causality constraints is also examined.
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    Circuits, systems and signal processing 1 (1982), S. 137-169 
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    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract A recently developed algebraic approach to the feedback system design problem is reviewed via the derivation of the theory in the single-variate case. This allows the simple algebraic nature of the theory to be brought to the fore while simultaneously minimizing the complexities of the presentation. Rather than simply giving a single solution to the prescribed design problem we endeavor to give a complete parameterization of the set of compensators which meet specifications. Although this might at first seem to complicate our theory it, in fact, opens the way for a sequential approach to the design problem in which one parameterizes the subset of those compensators which meet the second specification...etc. Specific problems investigated include feedback system stabilization, the tracking and disturbance rejection problem, robust design, transfer function design, pole placement, simultaneous stabilization, and stable stabilization.
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    Circuits, systems and signal processing 1 (1982), S. 267-268 
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    Circuits, systems and signal processing 1 (1982), S. 433-445 
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    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract We describe a recently developed framework for exploring the structure of linear time-invariant models of large systems, and for constructing interpretable or physically-based, reduced-order models that reproduce selected modes of the original systems to a desired accuracy. Application of this framework to constructing lumped approximations for interconnections of lumped and distributed systems is briefly explored.
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    Bulletin of mathematical biology 26 (1964), S. 25-29 
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    Notes: Abstract Error-detecting codes have been known to mathematicians and to electrical engineers for over ten years. In general, such codes utilize an additional orparity bit for purposes of detecting errors by the addition of all positive binary bits or “1’s” occurring in any code word. However, since the process of addition is required for such code detection, it is not surprising that these codes have not been applied to the nucleic acid molecule. In 1962, P. I. Hershberg (Trans. I.R.E., CS-10, 280–4, 1962) outlined a categorical constraint which permitted the realization of a class of error-detecting codes which did not require parity bits. This class of codes is applied to the nucleic acid molecule in the present paper.
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    Bulletin of mathematical biology 26 (1964), S. 31-38 
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    Notes: Abstract Compartment systems are often used as models for tracer and drug kinetics. The structure of a compartment system is here analyzed by means of theory of graphs methods. In particular the precursor-successor relationship between any two compartments is classified according to the structure of the graph of the system and to the values of the elements of the matrix associated with it.
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    Bulletin of mathematical biology 26 (1964), S. 39-43 
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    Notes: Abstract An application of a bifurcation theorem shows the existence of periodic solutions of a system of differential equation used to describe competition between two species. It is then shown that the results are more general than those previously established.
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    Bulletin of mathematical biology 26 (1964), S. 9-24 
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    Notes: Abstract The 2o and 10o field color-matching functions are independent: one specification is not a linear transformation of the other, even after correcting for macular pigment effects. Therefore, the “true” color-matching functions which directly describe the linear responses of the eye must be different for the two field sizes. This means that a given stimulus will, in general, have a different chromaticity depending upon the field size, regardless of the choice of any one colorimetric co-ordinate system for all field sizes. However, in spite of these chromaticity differences, a large uniform field usually appears nearly uniform. Such color uniformity implies that even though chromatic differences occur as a function of retinal position or field size, these differences are small. If this is the case, then the underling “true” color-matching functions determining the observed color-matching functions must be nearly, but not quite, identical. These differences vanish as identity between the sets of color-matching functions is approached. This property suggests a method of calculating the “true” color-matching functions. The “true” color-matching functions must approximate those obtained by minimizing the chromaticity differences between two independent sets of data. This can be done by assuming that the coefficients of transformation should be adjusted so as to produce as nearly identical chromaticities for spectrum stimuli as possible. In this paper, it is also assumed that the “true” color-matching functions have no negative values, as if they were based on actual absorption spectra. This article describes the calculation of the “true” 2o and 10o field color-matching functions satisfying these two conditions. For both field sizes, the maxima of the three functions are near 435, 540, and 585 mμ, after correcting for the filtering effects of the ocular media and macular pigment.
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    Bulletin of mathematical biology 26 (1964), S. 45-47 
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    Notes: Abstract In this note the principal convergence theorem (F. Rosenblatt,Principles of Neurodynamics, Spartan Books, Washington D.C., 1962, 111–116) is proved by a new method.
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    Bulletin of mathematical biology 26 (1964), S. 49-55 
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    Notes: Abstract Considering only nearest neighbor interactions, an expression is obtained for the grand partition function for the adsorption of two kinds of monovalent positive ions at a long chain of one type of monovalent negative fixed sites in an electric field. Expressions are obtained for the fractions of sites which are occupied by each kind of ion as well as of those which are unoccupied as a function of the potential of the electric field.
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    Bulletin of mathematical biology 26 (1964), S. 57-61 
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    Notes: Abstract In connection with a series of previous papers by this author (Bulletin of Mathematical Biophysics,21, 299–308, 375–385;22, 257–262, 263–267;23, 19–29;24, 319–325) results obtained by A. Crawford (Economics 5, 417–428) on the effects of irrelevant lights on reaction times toward a given light stimulus are discussed. The conclusions from a previous paper of this author (Bulletin of Mathematical Biophysics,23, 19–29) are elaborated.
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    Bulletin of mathematical biology 26 (1964), S. 77-81 
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    Notes: Abstract A mathematical model has been constructed to describe experimental data recorded in a study of a simple avoidance situation. The theoretical description makes use of the concept of the effective number of shocks. The model explains the existence of oscillations encountered in previous experiments.
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    Bulletin of mathematical biology 26 (1964), S. 63-75 
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    Notes: Abstract Response probabilities are interpreted from two points of view. One corresponds to fluctuations in physical parameters suggestive of a neurological basis, and the other corresponds to fluctuations in stimulus sample constitution. The two interpretations are shown to be equivalent under rather general conditions, giving the same type of relation between response and training states. This relation is different from that obtained via the response strength concept used in Part I. As a step toward evaluating the difference in predicted behavior for these different response-training relations, a general functional-difference equation is derived that describes the moments of the corresponding stochastic process in experimenter-subject controlled experiments. As an immediate application, it is used to obtain the continuity condition for the solution of the functional equation treated in Part I, and to justify the differentiability conditions assumed in establishing asymptotic properties of the solution as a function of the reinforcement parameter.
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    Bulletin of mathematical biology 26 (1964), S. 83-89 
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    Notes: Abstract A simple avoidance situation is considered in terms of a neural net learning model. Data for the control situation can be represented by an expression having three parameters which determine the initial and the steady state activities together with the transient aspects. The introduction of a learning parameter then allows one to calculate satisfactorily the results obtained in the experimental situation in which shock is applied.
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    Bulletin of mathematical biology 26 (1964), S. 101-101 
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    Bulletin of mathematical biology 26 (1964), S. 91-100 
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    Notes: Abstract An algebraic representation of operations of genetic recombinations is illustrated. It is shown that the recombinations between chromosomes in the two-strand model can be represented by groups, in the sense of the theory of groups. Recombinations between chromosomes with inversions and a translocation are considered as well as cases without them. It is found that the groups derived from such cases are Abelianp-groups (p=2) and that the types of the Abelian groups for the various pairs of chromosomes are different from each other. Differences among those recombination groups are illustrated by showing the sets of generators of the various groups, which generate the corresponding recombination groups by multiplication.
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    Bulletin of mathematical biology 26 (1964), S. 103-111 
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    Notes: Abstract It is shown that a rather close relationship exists between the (ℳ,ℛ)-systems, defined previously as prototypes of abstract biological systems, and the sequential machines which have been studied by various authors. The theory of sequential machines is reformulated in a way suitable for its application to the study of the intertransformability of (ℳ,ℛ)-systems as a result of environmental alteration. The important concept of strong connectedness is most useful in this direction, and is used to derive a number of results on intertransformability. Some suggestions are made for further studies along these lines.
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    Bulletin of mathematical biology 26 (1964), S. 113-120 
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    Notes: Abstract Blood flows into the aorta and its branches during left ventricular systole. Most of the arterial walls in the body stretch during systole in accordance with their elastic properties (Roston, 1962a, b). During diastole, the rebound of the distended walls supplies an additional propulsive force pushing the blood forward. Since the metabolic exchange between most of the tissues in the body and their blood vessels is ordinarily the same throughout the cardiac cycle, it makes little difference whether or not the blood flow occurs during systole or diastole. The circulation in the coronary arteries behaves in a quite different way. Because the muscle fibers of the heart contract during systole and relax during diastole, different conditions for blood flow and metabolic exchange exist during the phases of the cardiac cycle. As a result, specification of whether blood flows in the coronary arteries during systole or diastole may be important. Such specification complicates the study of the coronary artery circulation. For example, because of the arterial elasticity, some of the blood which enters the coronary arteries during diastole comes in contact with the muscle fibers during systole. The present work contains a theoretical study of the coronary artery circulation.
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    Bulletin of mathematical biology 26 (1964), S. 139-146 
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    Notes: Abstract A study is made of the adsorption of one kind of monovalent positive ion at a long chain of alternating monovalent negative fixed charged (“lattice”) and uncharged (“interstitial”) sites both of one type in an electric field. Considering only nearest neighbor interactions an expression is obtained for the grand partition function. The fractions of sites of both types which are occupied and unoccupied are determined. It is shown that an equilibrium constant can be defined for the adsorption of ions at oppositely charged sites.
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    Bulletin of mathematical biology 26 (1964), S. 121-138 
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    Notes: Abstract This paper proposes a model for color perception which accounts for variations in the dimension of the space of perceived colors. The model assumes that there is only one type of cone with only one shape of response curve, but that different cone's response curves differ by translation. It also assumes that the final discrimination system, learned from originally random connections, maximizes discrimination in the normal visual environment. Learning mechanisms are discussed, and the form which the final discrimination system ought to take is plausibly derived. An algorithm for the tristimulus curves is obtained from this model, and it is shown that a good fit of the empirical data can be obtained.
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    Bulletin of mathematical biology 26 (1964), S. 187-191 
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    Notes: Abstract It has been suggested by Robert Rosen (Bull. Math. Biophysics,22, 227–255, 1960) that multiple alleles or pseudoalleles correspond to multiple cites of degenerate states of some quantum mechanical observable which acts as a source of primary genetic information. It is pointed out here that if the quantum mechanical states are determined by the different sequences of the purine and pyrimidine bases in the DNA molecule, the expected number of pseudoalleles would be much too large. The expected number is considerably reduced if we assume that a quantum mechanical state determines the coupling between a molecule of transfer RNA and the corresponding amino acid.
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    Bulletin of mathematical biology 26 (1964), S. 147-166 
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    Notes: Abstract This paper describes a mathematical model developed to simulate the physical characteristics of the human thermal system in the transient state. Physiological parameters, such as local metabolic heat generation rates, local blood flow rates, and rates of sweating, must be specified as input data. Automatic computation of these parameters will be built into the model at a later date when it is used to study thermal regulation in the human. Finite-difference techniques have been used to solve the heat conduction equation on a Control Data Corporation 1604 computer. Since numerical techniques were used, it was possible to include many more factors in this model than in previous ones. The body was divided into 15 geometric regions, which were the head, the thorax, the abdomen, and the proximal, medial, and distal segments of the arms and legs. Axial gradients in a given segment were neglected. In each segment, the large arteries and veins were approximated by an arterial pool and a venous pool which were distributed radially throughout the segment. Accumulation of heat in the blood of the large arteries and veins, and heat transfer from the large arteries and veins to the surrounding tissue were taken into account. The venous streams were collected together at the heart before flowing into the capillaries of the lungs. Each of the segments was subdivided into 15 radial sections, thereby allowing considerable freedom in the assignment of physical properties such as thermal conductivity and rate of blood flow to the capillaries. The program has been carefully checked for errors, and it is now being used to analyze some problems of current interest.
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    Bulletin of mathematical biology 26 (1964), S. 193-198 
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    Notes: Abstract A model is introduced in which the reabsorption of sodium is governed by an enzymatic process. This process is in turn assumed to be influenced by the extracellular volume which depends on the amount of sodium in the body at a given time. The model allows for damped oscillations when the sodium intake lies within range of values and thus can account for observed oscillations.
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    Bulletin of mathematical biology 26 (1964), S. 167-185 
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    Notes: Abstract A neurobiophysical model is proposed for the explanation of some characteristics of schizophrenic behavior. The normal reactions to exogenous stimuli are mediated through a set of centers, while some endogenous stimuli result in abnormal reactions removed from reality, such as dreamlike states, paranoias, hallucinations, etc. The two sets of centers are cross-inhibited and the usual equations for such cross-inhibited systems are applied. In normal life exogenous stimuli as a rule result preponderantly in pleasant reactions, and the corresponding pathways are therefore reinforced. This results in an inhibition of the abnormal reactions. If the life history of an individual is such that a sufficiently large number of ordinarily experienced stimuli leads to unpleasant reactions and, therefore, the corresponding pathways are inhibited, the endogenously stimulated centers for abnormal reactions prevail and various schizophrenic symptoms occur. The same result may be achieved with a normal life history but through organic changes in the system, which differentially affect various thresholds and excitation parameters. The model thus leads to the conclusion that what appears now to be a large array of contradictory findings in the “organic” versus the “psychological” controversy is actually not a contradiction, but is a result of the dependence of normal and abnormal behaviors on a large number of neurobiophysical parameters. Some general comparisons between the conclusions drawn from the model and some known facts are made. The model also provides a first step toward a neurobiophysical interpretation of the mechanism of psychotherapy.
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    Bulletin of mathematical biology 42 (1980), S. 147-160 
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    Notes: Abstract A theory of noise fluctuations is developed which is applicable to systems of any size in which unimolecular or bimolecular reactions are occurring. The main difference between small and large reacting systems is that in the former the probability of finding a particle in a particular state does not obey a Gaussian distribution, but satisfies a distribution which reflects the mechanism of the chemical reaction. This difference is reflected in the main result of the theory: an autocorrelation function that is expressible as a sum of exponentials, the amplitudes of which are explicit functions of the moments of the distribution. Thus, by using small systems, the autocorrelation function,in principle, allows the elucidation of reaction mechanisms. Numerical simulations indicate that for reacting systems having ten or fewer particles, the deviation of the autocorrelation function from a single exponential should be easily detectable, and that estimates of the first four moments of the distribution should be possible. Accurate inference of the distribution, however, will require further mathematical and experimental advances.
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    Bulletin of mathematical biology 42 (1980), S. 161-172 
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    Notes: Abstract The recent mathematical formalization of the concepts of matter and extrinsical energy, which are used for the relational representation of biological systems, is employed in the analysis of the important experimental discoveries of Comorosanet al. related to low energy electromagnetic irradiations on enzyme substrates. By means of the present analysis one of the properties inherent to the experimental phenomena is more precisely exposed, and theoretical developments corresponding to “energetical evolutions” in a biological system (Leguizamón, 1976) may now have an experimental basis. Important limitations are introduced for the validity of the commutativity and associativity of cartesian product of sets, when they represent matter and its linked extrinsical energy. In connection with this last aspect, new important knowledge is obtained for the relational mathematical representation of biological systems.
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    Bulletin of mathematical biology 42 (1980), S. 397-429 
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    Notes: Abstract The structure of solutions to a simple spatially dependent population model involving growth and death is investigated. Two forms of motility of the population are considered: (1) random motion only modeled by a Fickian law, and (2) a directed component of motion (chemotaxis), included in addition to the random motion. Under certain growth conditions a traveling wave of constant speed is approached. This speed can be increased by the addition of the chemotaxis with a corresponding increase in the asymptotic population. Development of initial conditions into a wave is illustrated numerically.
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    Bulletin of mathematical biology 42 (1980), S. 365-396 
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    Notes: Abstract This paper describes mechanisms of intracellular and intercellular adaptation that are due to spatial or temporal factors. The spatial mechanisms support self-regulating pattern formation that is capable of directing self-organization in a large class of systems, including examples of directed intercellular growth, transmitter production, and intracellular conductance changes. A balance between intracellular flows and counterflows causes adaptation. This balance can be shifted by environmental inputs. The decrease in Ca2+-modulated outward K+ conductance in certain molluscan nerve cells is a likely example. Examples wherein Ca2+ acts as a second messenger that shunts receptor sensitivity can also be discussed from this perspective. The systems differ in basic ways from recent diffusion models. Chemical transducers driven by membrane-bound intracellular signals can establish long-range intercellular interactions that compensate for variable intercellular distances and are invariant under developmental size changes; diffusional signals do not. The intracellular adaptational mechanisms are formally analogous to intercellular mechanisms that include cellular properties which are omitted in recent reaction-diffusion models of pattern formation. The cellular models use these properties to compute size-invariant properties despite wide variations in their intercellular signals. Mechanisms of temporal adaptation can be derived from the simplest laws of chemical transduction by using a correspondence principle. These mechanisms lead to such properties of intercellular signals as transient overshoot, antagonistic rebound, and an inverted U in sensitivity as intracellular signals or adaptation levels shift. Such effects are implicated in studies of behavioral, reinforcement, motor control, and cognitive coding.
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    Bulletin of mathematical biology 42 (1980), S. 447-459 
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    Notes: Abstract Large radiation doses to the lung can cause early death from cardiopulmonary insufficiency resulting from radiation pneumonitis and pulmonary fibrosis. A model for early death following inhalation of insoluble radioactive particles is propose. The model is based on three assumptions: (1) early death results from damage to a cluster of cells from a large number of cell clusters at risk, (2) the dose that causes early death depends on how the radiation is delivered in time and (3) the cell clusters at risk to damage are equally sensitive ro radiation. Results from asymptotic theory of extreme values, along with biophysical considerations, suggest that the cumultive distribution function for the absorbed radiation dose to the production of pulmonary injury sufficient to cause early death is best estimated by the third asymptotic distribution without a threshold. This distribution function is identical to the Weibull cumulative distribution function. Data for Beagle dogs after inhaling relatively insoluble forms of alpha- or beta-gamma-emitting particles are shown to support the Weibull model.
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    Bulletin of mathematical biology 42 (1980), S. 461-480 
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    Notes: Abstract Models of the human respiratory tract were developed based on detailed morphometric measurements of a silicone rubber cast of the human tracheobronchial airways. Emphasis was placed on the “Typical Path Lung Model” which used one typical pathway to represent a portion of the lung, such as a lobe, or to represent the whole lung. The models contain geometrical parameters, including airway segment diameters, lengths, branching angles and angles of inclination to gravity, which are needed for estimating inhaled particle deposition. Aerosol depositions for various breathing patterns and particle sizes were calculated using these lung models and the modified Findeisen-Landahl computational scheme. The results agree reasonably well with recent experimental data. Regional deposition, including lobar deposition fractions, are also calculated and compared with results based on the ICRP lung deposition model.
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    Bulletin of mathematical biology 42 (1980), S. 481-488 
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    Notes: Abstract The completely symmetrical system is defined as having identical transfer coefficients between pairs of compartments and the same loss coefficient for each compartment. The eigenvalues and eigenvector are explicitly found along with the inverses of the system matrix and the matrix of eigenvectors. Many properties, special instances of more general theorems, can be seen at once from the explicit analytic solution of the initial value, washout and washin problems. The system serves as a known case for testing estimation procedures, algorithms for solutions of linear systems, eigenvalue-eigenvector and inversion routines and is of considerable tutorial value.
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    Bulletin of mathematical biology 42 (1980), S. 431-446 
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    Notes: Abstract The mathematical structures underlying the theories of organismic sets, (M, R)-systems and molecular sets are shown to be transformed naturally within the theory of categories and functors. Their natural transformations allow the comparison of distinct entities, as well as the modelling of dynamics in “organismic” structures.
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    Bulletin of mathematical biology 42 (1980), S. 489-505 
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    Notes: Abstract To explain the sodium conductance change using Wei's dipole model (Wei, 1969), we may expect that during depolarization the dipole's population difference, ΔN, is first reduced and then returns more slowly to its resting value. This paper shows that the experimental results of gating currents support this idea. Such time course of ΔN, however, is not a usual relaxation process. To account for the unusual behavior of ΔN, we propose two additional assumptions: (1) there exists a special coupling system (probably the intramolecular vibrations) whose coupling strength with the dipoles is much stronger than with the thermal bath (intermolecular vibrations), and (2) there also exist “traps” for the dipole's excitation energy so that this energy is transformed into other energy forms at a rate increasing with the increase of depolarization. Experiments suggest that the traps are proteins located at the inner membrane surface.
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    Bulletin of mathematical biology 42 (1980), S. 507-528 
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    Notes: Abstract Current research into the dynamics of iterative ecological and biological models has lead to a number of theorems concerning the existence of various types of iterative dynamical behavior. In particular, much study has been done on the dynamical behavior of the “simplest dynamical system”f b(x)=bx(1−x), which is just the canonical discrete form of logistic growth equations found in ecology, sociobiology, and population biology. In this paper, we make use of some of the techniques and concepts of topological dynamics to construct a number of generalized conjugacy theorems. These theorems are then used to demonstrate that the mappingf b has a number of conjugacy classes in which the dynamics of the iterates is equivalent to within a change of variables. The concepts of fitness and survival in logistic equations are then shown to be independent, if we follow certain intuitive definitions for these concepts. This conclusion follows from a comparison of the conjugacy classes of the functionf b and the extinction sets off b.
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    Notes: Abstract For chemical reactions not at equilibrium but proceeding in the forward direction in the steady state, a result found by a method first introduced by H. G. Britton (1963, 1965) is generalized to prove that if $${{\vec J} \mathord{\left/ {\vphantom {{\vec J} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}} \right. \kern-\nulldelimiterspace} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}$$ is the unidirectional flux ratio, $${{\vec J} \mathord{\left/ {\vphantom {{\vec J} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}} \right. \kern-\nulldelimiterspace} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}$$ exp (−ΔG/RT). The conditions under which the equality or inequality applies are discussed. If the unidirectional fluxes are not in the steady state, the unidirectional flux ratio is time invariant in certain specific situations. One such important case is for chemical reaction systems with an ordered sequence of reactions. For systems with more than one pathway, $${{\vec J} \mathord{\left/ {\vphantom {{\vec J} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}} \right. \kern-\nulldelimiterspace} {\overset{\lower0.5em\hbox{$\smash{\scriptscriptstyle\leftarrow}$}}{J} }}$$ is not constant except for special cases. These results also apply to diffusional and active transport systems.
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    Bulletin of mathematical biology 42 (1980), S. 599-600 
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    Bulletin of mathematical biology 42 (1980), S. 539-549 
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    Bulletin of mathematical biology 42 (1980), S. 551-597 
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    Notes: Abstract The nonlinear second-order difference equationx n+1=axn(1-xn−1), where 0≦x nX≦1 anda ≧1, is examined from varying points of view, analytical, numerical and geometrical. An analytic expression is obtained for an invariant attracting curveC ∞ (a) in phase space, which becomes the central object of study. This basic curve, which replaces the simple parabolic shape typical of many analogous first-order models, may have a complicated geometrical structure. As the parametera increases,C ∞(a) undergoes transformations characterized by the dynamical descriptions: stable node→stable focus→stable limit cycle →chaotic attractor. Although the limited characterization ofchaos by the appearance of nonperiodic solutions and solutions of arbitrarily large period is relied upon, this appears to be only a simplified approximation of the real behavior of solutions. Trajectories (x n, xn+1),n=0,1,…, are calculated using the related nonlinear planar mapT a(x,y)=(y,ay(1−x)), and regions of persistence and escape are described for characteristic values ofa. The study of persistence, of even more fundamental interest than the associated problems of periodicity and stability, receives special attention. We introduce a geometrical model, similar in many respects to that for the well-known analoguex n+1=axn(1−x n), but having several new and important features. It appears that as the parametera increases in the chaotic regime there are infinitely many intermittent bursts of increase in the probability that any initial point (x 0, x1) will persist in the unit square under successive iterations of the mappingT a, an unexpected property that should be of interest for applications. A discussion of the applicability of these results to population dynamics theory is given, and it is suggested that such equations might find useful application to problems in developmental biology as well.
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    Bulletin of mathematical biology 42 (1980), S. 627-645 
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    Notes: Abstract Based on the principle of minimum power, a mathematical model of the functional state of the oxygen transport system is presented. The optimization model minimizes the power expenditure of the heart, bone marrow, lung and other tissues. The model is used to determine the functional parameters of the oxygen transport system in man under both normal and varying barometric pressures. Theoretical results are compared with experimental data.
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    Bulletin of mathematical biology 42 (1980), S. 601-625 
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    Notes: Abstract A quantitative model of ion binding and molecular interactions in the lipid bilayer membrane is proposed and found to be useful in examining the factors underlying such membrane characteristics as shape, sidedness, stability and vesicle size at various cation concentrations. The lipid membrane behaves as a bilayer couple whose preferential radius of curvature depends on the expansion or contraction of one monolayer relative to the other. It is proposed that molecular packing may be altered by electrostatic repulsion of adjacent like-charged phospholipid headgroups, or by bringing two headgroups closer together by divalent cation crossbridging. The surface concentrations of each type of cation-phospholipid complex can be described by simple binding equilibria and the Gouy-Chapman-Stern formulation for the surface potential in a diffuse double layer. The asymmetric distribution of acidic phospholipids in most biological membranes can account for the differential effects of identical ionic environments on either side of the bilayer. The fraction of vesicle material which tends to have a right-side-out orientation may be approximated by a normal distribution about the mean curvature. The theory generates vesicle sidedness distributions that, when fitted to experimental results from human erythrocyte membranes, provide an alternative method of estimating intrinsic cationphospholipid dissociation constants and other molecular parameters of the bilayer. The results also corroborate earlier suggestions that the Gouy-Chapman theory tends to overestimate free counter-ion concentrations at the surface under large surface potentials.
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    Bulletin of mathematical biology 42 (1980), S. 681-689 
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    Notes: Abstract The “yellow strips” on the cuticle of the Oriental Hornet (Vespa orientalis, Hymenoptera, Vespinae), present photoelectric properties. A mathematical model for the relative changes in resistance as a photoconductive process conforms to the general model for a semiconductor with traps.
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    Bulletin of mathematical biology 42 (1980), S. 701-718 
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    Notes: Abstract Damped nonlinear oscillations in biological and biochemical systems are investigated by the extended Krylov-Bogoliubov-Mitropolskii (KBM) method. A review on the extension made by Popov to the KBM method is given and also further improvements are presented. Applications are made to models of oscillating chemical reactions (Lefever and Nicolis, 1971), FitzHugh (1961) equations, and population dynamics (Gatto and Rinaldi, 1977). Comparison to damped oscillating physical and engineering systems is made.
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    Bulletin of mathematical biology 42 (1980), S. 719-728 
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    Notes: Abstract The conditions that will allow the lumping together of several age classes in the Leslie model are investigated. We show that if the lumping is to be valid for all population distributions, then the parameters of the model must be periodic. Lumping is valid when the population is in equilibrium, but equilibrium should be tested before the model is lumped.
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    Bulletin of mathematical biology 42 (1980), S. 647-679 
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    Notes: Abstract Catastrophe theory is a mathematical theory which, allied with a new and controversial methodology, has claimed wide application, particularly in the biological and the social sciences. These claims have recently been heatedly opposed. This article describes the debate and assesses the merits of the different arguments advanced.
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    Bulletin of mathematical biology 42 (1980), S. 765-795 
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    Notes: Abstract Estimates of capillary tracer permeability calculated using multiple indicator data depend upon the particular model adopted to describe blood tissue exchange. The model proposed by Crone (1963) is appropriate when some of the injected tracer diffuses into the tissue but does not return appreciably to the bloodstream before data collection is terminated. Under these conditions extraction of tracer by the tissue depends on a single dimensionless parameter, αcap, defined as the ratio of capillary permeability surface area to water flow. The effects of finite red cell tracer permeability on the Crone model estimate of capillary permeability are examined in the present study. The results indicate that even when back diffusion from the extravascular space is negligible, significant errors in the Crone model estimate can be expected when capillary permeability is relatively high and the ratio of red cell to capillary permeability is less than unity. However, when an aliquot of blood is equilibrated with tracer prior to injection and the dimensionless capillary permeability is relatively low (i.e. αcap ≦ 0.25 for a haematocrit≦50%), the whole blood Crone model estimate of αcap will be within 10% of the actual value, irrespective of red cell permeability. Red cell-plasma exchange for commonly used tracer-organ combinations should not significantly affect Crone estimates of capillary permeability under normal physiological conditions, but may be important in low flow situations.
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    Bulletin of mathematical biology 42 (1980), S. 807-828 
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    Notes: Abstract Assuming truncated ellipsoidal geometry for the right and left ventricles, a model is developed for the myocardium enabling biventricular mechanical behavior to be studied. Employing pressure-volume data taken from normal dog hearts and from hearts in which the pulmonary artery has been banded over periods of 2–40 weeks, it is shown that: (a) right ventricular wall stresses are higher than left ventricular stresses; (b) right ventricular wall stress increases initially to a maximum after 3–4 weeks followed by a decline to normal and even subnormal levels, attaining a minimum value at 32–33 weeks; (c) left ventricular stresses behave in a similar manner, attaining their maximum and minimum levels after 7–8 weeks and 32–33 weeks respectively. These results suggest that surgical or medical therapy in patients with hypertrophied ventricles might be more appropriate during the period of wall stress reduction.
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    Bulletin of mathematical biology 42 (1980), S. 837-845 
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    Notes: Abstract In this paper we describe a mathematical model of the oscillations of the diaphragm which limits the vitreous body from the anterior segment of the human eye after the lens has been removed in a cataract operation. We study the motion of this diaphragm driven by movements of the eye. Firstly, a mathematical statement of the problem is given and then we solve the problem exactly for a given class of eye movements. From the analysis we deduce that significant oscillations of the membrane are driven by saccades and that it is the angular acceleration of the eye which causes these types of oscillations. A numerical example is given.
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    Bulletin of mathematical biology 42 (1980), S. 871-887 
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    Notes: Abstract The Lotka-Volterra system of prey-predator equations is considered with a special type of continuous time delay. In the case of equal diffusion coefficients Hopf’s bifurcation technique is used to show the existence of travelling wave train solutions for the prey-predator system.
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    Bulletin of mathematical biology 42 (1980), S. 861-870 
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    Notes: Abstract A mathematical model of prothrombin activation is being proposed which includes the feedback mechanism of thrombin and the alteration of factor V by thrombin. This model is in good agreement with experimental data for the dependence of the rate of thrombin formation on the concentrations of factors V and X a . In particular, it correctly predicts the existence and location of a maximum in both of these cases.
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    Bulletin of mathematical biology 42 (1980), S. 847-859 
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    Notes: Abstract A new model of the upper tracheobronchial tree is proposed to account for the three-dimensional nature of the airway system. In addition to the tube length, the tube diameter, and the branching angle, the model includes information on the orientation angle of each tube relative to its parent tube. The orientation angle, defined as the angle between two successive bifurcations, is useful for calculating the gravitational inclination of each tube. The information on orientation angle is further used to construct a binary coding system for identifying individual tubes in the airway tree. The proposed model is asymmetrical, but the same principles can be readily used to construct a symmetrical one.
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    Bulletin of mathematical biology 42 (1980), S. 889-897 
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    Notes: Abstract In any control system for which the number of independent controls is smaller than the number of degrees of freedom to be controlled, our choice of control in any state is restricted to a submanifold of smaller dimension than the tangent space. This simple fact has a number of important consequences for questions of biological import; we consider its implications for adaptation, for senescent phenomena and for the determination of tertiary structures of polypeptides through control of certain average properties. We also formulate the Pontryagin Maximum Principle of Optimal control theory in such a way as to inquire whether specific biodynamic systems can be regarded as optimal with respect to rate of accumulation of particular quantities of the system. We find that if this is possible, the quantity in question must play the role of a clock.
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    Bulletin of mathematical biology 42 (1980), S. 899-900 
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    Bulletin of mathematical biology 44 (1982), S. 17-28 
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    Notes: Abstract The concept of natural selection is examined, which is one of basic principles for the Darwinian interpretation of evolution. In this model selection is defined as a solution of the deterministic Eigen equation. Next, the random effect is introduced through the mutation term. However, the probability of finding the solution expressing the selection is shown to be smallest. The validity of the model and its applicability to polynucleotide replication are discussed.
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    Bulletin of mathematical biology 44 (1982), S. 135-147 
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    Notes: Abstract Using numerical methods, the initial rates of oxygen uptake by the red blood cell have been computed. The methods accommodate both a water layer and membrane which may act as diffusive impedance to gas influx. The differential solubilities of the gas in these two layers have also been incorporated in the methods. The presence of a 0.50–0.65 μm deoxygenated water layer has been calculated to simulate the experimental results by Roughton (1959). Experimental studies of CO and NO uptake by the red cell could also be simulated. Although a membrane-only model with given parameters can also account for the observed rates of oxygenation of the red cell (Weingardenet al., submitted for publication), the additional incorporation of differential solubilities of oxygen in the different layers of the RBC yields results that indicate a three layer model to be more plausible. Using a thin layer-red cell oxygenation system, the rates of oxygenation were determined for red cells surrounded by a 4.2 μm deoxygenated water layer. The rates were found to compare favorably to the results of the theoretical model.
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    Bulletin of mathematical biology 44 (1982), S. 151-151 
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    Bulletin of mathematical biology 44 (1982), S. 152-152 
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    Bulletin of mathematical biology 44 (1982), S. 175-192 
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    Notes: Abstract Due to the complicated physiological structure of soft biological tissues, stresses can only be measured after the specimen has been stretched to many times of its related length. Therefore, the classical constitutive equations of finite elasticity developed for vulcanized, rubbery materials and the linear theories developed for most engineering materials cannot be applied to soft tissues which are highly elastic in nature. In this article, utilizing a mechanical model developed by Demiray for soft tissues, a class of finite deformations of some tissues is studied and the results are compared with experiment and the existing literature. These problems are the simultaneous extension and twisting of a circular cylindrical bar, the bending of a rectangular block, and the pure shear of a rectangular prism. It is believed that solutions to these problems may find some applications in plastic surgery.
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    Notes: Abstract In this paper, effects of convective and dispersive migration on the linear stability of the equilibrium state of a two species system with mutualistic interactions and functional response have been investigated. In both finite and semi-infinite habitats, it has been shown that the otherwise stable equilibrium state without dispersal remains so with dispersal also, both under flux and reservior conditions. In the case of finite habitat, the degree of stability increases as dispersal coefficients of the two species increase. The effect of convective migration also is to stabilize the equilibrium state in this case.
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    Bulletin of mathematical biology 44 (1982), S. 307-307 
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    Bulletin of mathematical biology 44 (1982), S. 283-305 
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    Notes: Abstract A linear spatially distributed model of a chain of neurons and interneurons was investigated in relation to the generation of propagated alpha rhythmic activity. It was assumed that the elements of the chain were interconnected by means of recurrent collaterals and inhibitory fibres in such a way that the connectivity functions were assumed to be homogeneous and their strength was an exponentially decreasing function of distance. It was found that such a neuronal chain shows propagation properties for frequencies in the alpha band. The results obtained with the model are in agreement with the phase velocities encountered experimentally. In this way, it was possible to estimate the length of the neural fibres responsible for the phenomenon of propagated activity. The estimates obtained are in good agreement with recent quantitative neuroanatomical data on the circuitry of the neocortex.
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    Bulletin of mathematical biology 44 (1982), S. 309-320 
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    Notes: Abstract This paper characterizes the cycle structure of a completely random net. Variables such as number of cycles of a specified length, number of cycles, number of cyclic states and length of cycle are studied. A square array of indicator variables enables conveninent study of moment structure. Additionally, exact and asymptotic distributional results are presented.
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    Bulletin of mathematical biology 44 (1982), S. 321-337 
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    Notes: Abstract A class of nonlinear equations describing the steady propagation of a disturbance on the infinite interval in one dimensional space are shown under certain conditions to admit solution with a unique velocity of propagation. The class of equations describe both initial and final homogeneous steady states which are asymptotically stable with respect to uniform perturbations, in contrast to the Fisher equation, which does not.
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    Bulletin of mathematical biology 44 (1982), S. 399-409 
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    Notes: Abstract A model for insulin secretion with a storage and a labile compartment, as well as a provisionary factor, is combined with a signal model in which the signal can be the difference between an excitation and an inhibition, or the difference in concentrations inside and outside some cell components. The model, using a single set of values for the parameters, accounts in a semiquantitative manner for all of the regularly appearing features of the insulin secretion from thein vitro perfused pancreas to a wide range of patterns of glucose and tolbutamide stimulation. Among the features which can be accounted for are: early and late secretion of insulin as a function of glucose in terms of a single parameter; the apparent depletion and recovery during a pulsed pattern of stimulation by tolbutamide; the hypersecretion following a short period of rest during a prolonged stimulation by glucose; the negative spike which occurs when the concentration of glucose, which has been maintained for a period of time, is suddenly reduced to a lower level; and the appropriate responses to slow and fast ramp functions of glucose concentration.
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    Bulletin of mathematical biology 44 (1982), S. 443-447 
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    Notes: Abstract The incorporation of a chaotic component in a computing system is incompatible with its being effectively programmable. The example presented shows that concepts of programming suitable for biological systems may differ from those which have grown out of our experience with present day digital computers.
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    Bulletin of mathematical biology 44 (1982), S. 411-423 
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    Notes: Abstract An analysis of the interaction between stimulus molecules and the olfactory receptor cell membrane is presented. The model is based upon a sequence of events, i.e. stimulus delivery at the olfactory epithelium, absorption of molecules in the mucus layer, diffusion of the molecules towards the receptor cells and molecule-receptor cell membrane interaction. The mathematical analysis considers the situation during electrophysiological experiments, where an odour puff is delivered at an exposed olfactory mucosa. Such a situation resembles sniffing of odour samples. The analysis is discussed in relation to experimental evidence.
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    Bulletin of mathematical biology 44 (1982), S. 425-442 
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    Notes: Abstract A model is developed to calculate the deposition of hygroscopic aerosols in the human tracheobronchial (TB) tree. The TB airflow pattern assumed is consistent with experimental observations and accounts for anatomical features such as the larynx and cartilaginous rings in large airways. Some original deposition efficiency formulae are presented for laminar and turbulent airstreams. Stepwise growth is simulated by changes in particle size and density at each TB generation. The dose distribution of NaCl aerosols is studied as a function of inhaled particle size and flow rate. Two NaCl growth rate curves are used which differ in the mode of aerosol-air mixing in the trachea. The initial rate of aerosol mixing in the human due to the laryngeal jet is shown to be an important factor affecting the deposition of hygroscopic aerosols. Total TB deposition of NaCl exceeds that for nonhygroscopic particles of the same inhaled aerodynamic size. Hygroscopic growth can also influence the regional TB distribution of dose when submicron NaCl particles grow rapidly enough to deposit by impaction and sedimentation.
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    Bulletin of mathematical biology 44 (1982), S. 449-449 
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    Bulletin of mathematical biology 44 (1982), S. 451-452 
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    Bulletin of mathematical biology 44 (1982), S. 491-500 
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    Notes: Abstract Granted that a single or complex gene is responsible for inbreeding depression, theoretical expressions for fertility and viability are obtained in different diploid populations: brother-sister, half-brother-sister, cousins and double-cousins. The conclusions of the study of viability variations according to the coefficient of parentage are proved by the results of experiments and lead to a new view of genetic load.
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    Bulletin of mathematical biology 44 (1982), S. 501-535 
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    Notes: Abstract The Thom gradient model of morphogenesis poses the followinga posteriori problem: “From the observed morphology of a given natural process (effect) determine the dynamics of the process (cause)”. In this paper we consider the classicala priori problem: “Given the cause (dynamics) determine the effect (resultant morphology)”. We find that in biochemical processes the mechanisms for energy activation, energy-matter interaction and energy dissipation determine the dynamics. Furthermore there exists basic energy mechanisms which drive the equilibrium states through the elementary catastrophes of Thom. A comparison with current theories shows that our models describe open ecological food chains and their dynamical systems generalize the equations of organisation posed by M. Eigen.
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    Bulletin of mathematical biology 44 (1982), S. 549-555 
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    Notes: Abstract We show that the elementary models of biochemical evolutionary processes are the bases for the study of open ecological systems and macromolecular self-organisation. We deduce a biochemical analogue for the basic closed phytoplankton-zooplankton food chain. The perturbation of the Michaelis-Menten mechanism which determines the nutrient-dependent growth rate of the phytoplankton species leads to higher catastrophes for the nutrient equilibrium manifold. The umbilic models are generalizations of the equations of organization of Eigen.
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    Bulletin of mathematical biology 44 (1982), S. 761-775 
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    Notes: Abstract The transport equation of Kedem and Katchalsky for the flux of ions through a membrane is generalized to demonstrate explicitly the role of impermeant ions in determining its mathematical form. Whereas the Kedem-Katchalsky equation is linear in the salt concentrations in the bathing solutions, the more general equation is bilinear (and symmetric) in the ionic concentrations of the permeant species. The Kedem-Katchalsky flux equation is further generalized to include explicitly a term for ion-exchange in systems having more than a single permeant salt. This additional term is also bilinear (and antisymmetric) in the concentrations of the exchanging ionic species. Flux equations are derived for systems having (1) a single mono-monovalent salt, (2) two mono-monovalent salts and (3) an arbitrary number of salts with no restriction upon the valencies of the ionic components. Since it has no effect upon the form of concentration-dependent terms in the flux equations, coupling to volume flow is neglected.
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