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  • 1
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-07-08
    Description: Separation and purification are critical industrial processes for separating components of chemical mixtures, and these processes account for about half of industrial energy usage (1). Gas mixtures of compounds with very similar physical properties are particularly difficult to separate. On pages 137 and 141 of this issue, Cadiau et al. (2) and Cui et al. (3), respectively, show that microporous materials can be designed to have high adsorption capacity and selectivity for particular hydrocarbons, enabling energy-efficient separation. Author: Jerry Y. S. Lin
    Keywords: Chemistry
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  • 2
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-05-27
    Description: Biomass-degrading microorganisms use lytic polysaccharide monooxygenase (LPMO) enzymes to help digest cellulose, chitin, and starch. By cleaving otherwise inaccessible crystalline cellulose chains, these enzymes provide access to hydrolytic enzymes. LPMOs are of interest to biotechnology because efficient depolymerization of cellulose is a major bottleneck for the production of biologically based chemicals and fuels. On page 1098 of this issue, Kracher et al. (1) compare LPMO-reducing substrates in fungi from different taxonomic groups and lifestyles, based on both biochemical and genomic evidence. The results provide insights into reductive activation of LPMO that are important for developing more efficient industrial enzymes for lignocellulose biorefineries. Author: Angel T. Martínez
    Keywords: Chemistry
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  • 3
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-03-25
    Description: Author: Marc S. Lavine
    Keywords: Chemistry
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waldrop, M M -- New York, N.Y. -- Science. 1990 Aug 3;249(4968):472-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2382127" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Information Systems ; Jurisprudence ; Societies, Scientific ; United States
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-09-14
    Description: Direct osmotic stress measurements have been made of forces between helices of xanthan, an industrially important charged polysaccharide. Exponentially decaying hydration forces, much like those already measured between lipid bilayer membranes or DNA double helices, dominate the interactions at close separation. Interactions between uncharged schizophyllans also show the same kind of hydration force seen between xanthans. In addition to the practical possibilities for modifying solution and suspension properties through recognition and control of molecular forces, there is now finally the opportunity for theorists to relate macroscopic properties of a polymer solution to the microscopic properties that underlie them.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rau, D C -- Parsegian, V A -- New York, N.Y. -- Science. 1990 Sep 14;249(4974):1278-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institues of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2144663" target="_blank"〉PubMed〈/a〉
    Keywords: Carbohydrate Sequence ; Chemical Phenomena ; Chemistry ; Gels ; *Glycosaminoglycans ; Macromolecular Substances ; Molecular Sequence Data ; Osmosis ; *Polysaccharides, Bacterial ; *Sizofiran ; Solutions ; Viscosity
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-02
    Description: Protein unfolding and the dissolution of hydrophobic compounds (including solids, liquids, and gases) in water are characterized by a linear relation between entropy change and heat capacity change. The same slope is found for various classes of compounds, whereas the intercept depends on the particular class. The feature common to these processes is exposure of hydrophobic groups to water. These observations make possible the assignment of the heat capacity change to hydrophobic solvation and lead to the description of protein stability in terms of a hydrophobic and a nonhydrophobic contribution. A general representation of protein stability is given by the heat capacity change and the temperature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, K P -- Privalov, P L -- Gill, S J -- New York, N.Y. -- Science. 1990 Feb 2;247(4942):559-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2300815" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Protein Denaturation ; *Proteins ; Thermodynamics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-03-02
    Description: Ultrasound has become an important synthetic tool in liquid-solid chemical reactions, but the origins of the observed enhancements remained unknown. The effects of high-intensity ultrasound on solid-liquid slurries were examined. Turbulent flow and shock waves produced by acoustic cavitation were found to drive metal particles together at sufficiently high velocities to induce melting upon collision. A series of transition-metal powders were used to probe the maximum temperatures and speeds reached during such interparticle collisions. Metal particles that were irradiated in hydrocarbon liquids with ultrasound underwent collisions at roughly half the speed of sound and generated localized effective temperatures between 2600 degrees C and 3400 degrees C at the point of impact for particles with an average diameter of approximately 10 microns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doktycz, S J -- Suslick, K S -- New York, N.Y. -- Science. 1990 Mar 2;247(4946):1067-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Chemical Sciences, University of Illinois, Urbana 61801.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2309118" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Metals ; Microscopy, Electron, Scanning ; Microspheres ; *Ultrasonics
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-01-12
    Description: Experiments are presented that confirm earlier predictions that the mode of supply of reactants to a nonlinear (bio)chemical reaction determines or controls concentrations at steady states far from equilibrium. The oxidation of nicotinamide adenine dinucleotide (NADH) catalyzed by the enzyme horseradish peroxidase with continuous input of oxygen was studied; NAD+ is continuously recycled to NADH through a glucose-6-phosphate dehydrogenase system. A comparison of steady-state concentrations is made with an oscillatory oxygen input and a constant input at the same average oxygen input for both modes. By varying the frequency and amplitude of the perturbation (O2 influx), the following may be changed: the average concentration of NADH; the Gibbs free energy difference delta G of the reactants and products at steady state; the average rate of the reaction; the phase relation between the oscillatory rate and delta G; and the dissipation. These results confirm the possibility of an "alternating current chemistry," of control and optimization of thermodynamic efficiency and dissipation by means of external variation of constraints in classes of nonlinear reactions and biological pumps, and of improvements of the yield in such reactions (heterogeneous catalysis, for example).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazar, J G -- Ross, J -- New York, N.Y. -- Science. 1990 Jan 12;247(4939):189-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Stanford University, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2294601" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Chemical Phenomena ; Chemistry ; Glucosephosphate Dehydrogenase/*metabolism ; Horseradish Peroxidase/*metabolism ; Kinetics ; NAD/*metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Peroxidases/*metabolism ; Thermodynamics
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  • 9
    Publication Date: 1990-08-17
    Description: The interaction of a protein antigen, horse cytochrome c (cyt c), with a monoclonal antibody has been studied by hydrogen-deuterium (H-D) exchange labeling and two-dimensional nuclear magnetic resonance (2D NMR) methods. The H-exchange rate of residues in three discontiguous regions of the cyt c polypeptide backbone was slowed by factors up to 340-fold in the antibody-antigen complex compared with free cyt c. The protected residues, 36 to 38, 59, 60, 64 to 67, 100, and 101, and their hydrogen-bond acceptors, are brought together in the three-dimensional structure to form a contiguous, largely exposed protein surface with an area of about 750 square angstroms. The interaction site determined in this way is consistent with prior epitope mapping studies and includes several residues that were not previously identified. The hydrogen exchange labeling approach can be used to map binding sites on small proteins in antibody-antigen complexes and may be applicable to protein-protein and protein-ligand interactions in general.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432411/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432411/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paterson, Y -- Englander, S W -- Roder, H -- GM 31847/GM/NIGMS NIH HHS/ -- GM 35926/GM/NIGMS NIH HHS/ -- R01 GM031847/GM/NIGMS NIH HHS/ -- S07-RR-05415-28/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1990 Aug 17;249(4970):755-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Pennsylvania, Philadelphia 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1697101" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal/immunology/metabolism ; Antigen-Antibody Complex ; *Binding Sites, Antibody ; Chemical Phenomena ; Chemistry ; Cytochrome c Group/*immunology ; Deuterium ; Epitopes/immunology ; Hydrogen/*metabolism ; Hydrogen Bonding ; Kinetics ; *Magnetic Resonance Spectroscopy ; Molecular Structure ; Protein Conformation
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1990-02-23
    Description: Reactive or unstable molecules are key intermediates in many important reactions, but can be difficult to prepare for experimental studies. Species with missing (:CH-OH) or extra (H3) substituents can often be formed conveniently in the gas phase by neutralizing a beam of a more stable ionic counterpart (CH = O+H, H3+). Reionization of the neutral after approximately 10(-6) seconds tests its stability, whereas its unimolecular chemistry can be probed by preparing it with different amounts of internal energy. The resulting neutral products are reionized and mass analyzed. Isomers are then characterized by ion dissociation and a third mass-analysis step. Many unusual molecules have been characterized with this technique, which can also be used to probe complex unimolecular chemistry, such as that of cyclobutadiene and ethylene oxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McLafferty, F W -- GM-16609/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Feb 23;247(4945):925-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cornell University, Baker Laboratory, Ithaca, NY 14853-1301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2305261" target="_blank"〉PubMed〈/a〉
    Keywords: Butadienes ; Chemical Phenomena ; Chemistry ; Ethylene Oxide ; Free Radicals ; Hydrocarbons ; *Ions ; *Mass Spectrometry ; Methane/analogs & derivatives ; Molecular Structure ; Thermodynamics
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  • 11
    Publication Date: 1990-05-18
    Description: The immunosuppressive agents cyclosporin A and FK506 inhibit the transcription of early T cell activation genes. The binding proteins for cyclosporin A and FK506, cyclophilin and FKBP, respectively, are peptidyl-prolyl-cis-trans isomerases, or rotamases. One proposed mechanism for rotamase catalysis by cyclophilin involves a tetrahedral adduct of an amide carbonyl and an enzyme-bound nucleophile. The potent FKBP rotamase inhibitor FK506 has a highly electrophilic carbonyl that is adjacent to an acyl-pipicolinyl (homoprolyl) amide bond. Such a functional group would be expected to form a stabilized, enzyme-bound tetrahedral adduct. Spectroscopic and chemical evidence reveals that the drug interacts noncovalently with its receptor, suggesting that the alpha-keto amid of FK506 serves as a surrogate for the twisted amide of a bound peptide substrate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosen, M K -- Standaert, R F -- Galat, A -- Nakatsuka, M -- Schreiber, S L -- GM-38627/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 May 18;248(4957):863-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Harvard University, Cambridge, MA 02138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1693013" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Isomerases/*antagonists & inhibitors ; Anti-Bacterial Agents/metabolism/*pharmacology ; Binding Sites ; Carrier Proteins/antagonists & inhibitors/metabolism ; Chemical Phenomena ; Chemistry ; Cloning, Molecular ; Cyclosporins/metabolism/pharmacology ; Escherichia coli/genetics ; Gene Expression ; *Immunosuppressive Agents ; Lymphocyte Activation ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Peptidylprolyl Isomerase ; Recombinant Proteins ; T-Lymphocytes/immunology ; Tacrolimus
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  • 12
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-04-29
    Description: Author: Jake Yeston
    Keywords: Chemistry
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  • 13
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-03-18
    Description: Author: Marc S. Lavine
    Keywords: Chemistry
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  • 14
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-03-18
    Description: Water plays a central role in scientific disciplines ranging from geology to astronomy to biology. Yet it is an extraordinarily dif cult liquid to understand because of its complex, ever-changing patterns of hydrogen bonds. Studies of small water clusters have provided important insights into the concerted hydrogen-bond motions that can occur in water. These studies are also crucial for developing an accurate potential function for simulating the properties of liquid water and ice (1). On page 1310 of this issue, Richardson et al. (2) provide evidence for a concerted type of motion in which two hydrogen bonds in a water cluster are broken simultaneously (see the figure). The results have implications for many areas of scientific study, including the chemistry of polar solvents, the conformations of proteins, and the dissolution of ions in minerals. Author: David C. Clary
    Keywords: Chemistry
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  • 15
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-03-18
    Description: Author: Jake Yeston
    Keywords: Chemistry
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  • 16
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-03-04
    Description: Lower olefins, particularly ethylene (C2H4), propylene (C3H6), and butylene (C4H8), are important intermediates in the manufacture of products such as plastics, solvents, paints, and medicines. They are produced worldwide in amounts exceeding 200 million tons per year (see the photo) (1), mostly from crude oil. More recent approaches use methanol or synthesis gas (syngas; a mixture of carbon monoxide and hydrogen) as feedstocks, but capital investments are high and/or selectivities to lower olefins limited. A bifunctional catalyst reported by Jiao et al. on page 1065 of this issue (2) enables the direct conversion of synthesis gas to lower olefins with a surprisingly high selectivity. Author: Krijn P. de Jong
    Keywords: Chemistry
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  • 17
    Publication Date: 2016-09-02
    Description: Effective differentiation of prochiral carbon–hydrogen (C–H) bonds on a single methylene carbon via asymmetric metal insertion remains a challenge. Here, we report the discovery of chiral acetyl-protected aminoethyl quinoline ligands that enable asymmetric palladium insertion into prochiral C–H bonds on a single methylene carbon center. We apply these palladium complexes to catalytic enantioselective functionalization of β-methylene C–H bonds in aliphatic amides. Using bidentate ligands to accelerate C–H activation of otherwise unreactive monodentate substrates is crucial for outcompeting the background reaction driven by substrate-directed cyclopalladation, thereby avoiding erosion of enantioselectivity. The potential of ligand acceleration in C–H activation is also demonstrated by enantioselective β-C–H arylation of simple carboxylic acids without installing directing groups.
    Keywords: Chemistry
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  • 18
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-11-04
    Description: Author: Jake Yeston
    Keywords: Chemistry
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 21
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-11-25
    Description: Author: Jake Yeston
    Keywords: Chemistry
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 27
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-11-11
    Description: Although ammonia (NH3) is made on a vast scale for use in fertilizers, its use as a chemical feedstock or as an energy carrier is much more limited. Many reactions that occur easily with its substitution products (amines) are sluggish for NH3, in part because of the difficulty of activating the N-H bond. For fuel cells, NH3 is attractive because it does not generate greenhouse gases, as do methanol and methane (1), and is more easily stored than hydrogen (H2). Amine-containing organic molecules are used in pharmaceutical and materials applications, and accessing these structures directly from ammonia could limit the generation of by-products during their synthesis (2). Bringing NH3 up to speed for these applications will require both the development of catalysts that can activate the strong N–H bond of ammonia and a fundamental understanding of the N–H bond cleavage step. On page 730 of this issue, Bezdek et al. (3) report a molybdenum complex capable of weakening the N–H bond of NH3 and releasing a H atom to generate H2 under mild conditions. Author: Jessica Hoover
    Keywords: Chemistry
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  • 28
    Publication Date: 2016-09-02
    Description: Direct methods for stereoselective functionalization of sp 3 -hybridized carbon–hydrogen [C(sp 3 )–H] bonds in complex organic molecules could facilitate much more efficient preparation of therapeutics and agrochemicals. Here, we report a copper-catalyzed radical relay pathway for enantioselective conversion of benzylic C–H bonds into benzylic nitriles. Hydrogen-atom abstraction affords an achiral benzylic radical that undergoes asymmetric C(sp 3 )–CN bond formation upon reaction with a chiral copper catalyst. The reactions proceed efficiently at room temperature with the benzylic substrate as limiting reagent, exhibit broad substrate scope with high enantioselectivity (typically 90 to 99% enantiomeric excess), and afford products that are key precursors to important bioactive molecules. Mechanistic studies provide evidence for diffusible organic radicals and highlight the difference between these reactions and C–H oxidations mediated by enzymes and other catalysts that operate via radical rebound pathways.
    Keywords: Chemistry
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  • 29
    Publication Date: 2016-09-02
    Description: Oxygen electrochemistry plays a key role in renewable energy technologies such as fuel cells and electrolyzers, but the slow kinetics of the oxygen evolution reaction (OER) limit the performance and commercialization of such devices. Here we report an iridium oxide/strontium iridium oxide (IrO x /SrIrO 3 ) catalyst formed during electrochemical testing by strontium leaching from surface layers of thin films of SrIrO 3 . This catalyst has demonstrated specific activity at 10 milliamps per square centimeter of oxide catalyst (OER current normalized to catalyst surface area), with only 270 to 290 millivolts of overpotential for 30 hours of continuous testing in acidic electrolyte. Density functional theory calculations suggest the formation of highly active surface layers during strontium leaching with IrO 3 or anatase IrO 2 motifs. The IrO x /SrIrO 3 catalyst outperforms known IrO x and ruthenium oxide (RuO x ) systems, the only other OER catalysts that have reasonable activity in acidic electrolyte.
    Keywords: Chemistry
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  • 30
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-12-09
    Description: Author: Jake Yeston
    Keywords: Chemistry
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    Electronic ISSN: 1095-9203
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  • 31
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    Chemie Ingenieur Technik - CIT 22 (1950) 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 1-5 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 5-7 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Über die technischen Anwendungsmöglichkeiten reiner Strahlungserwärmung bestehen in der Praxis noch vielfach Unklarheiten. Nachstehend behandelte Beispiele aus dem Gebiet der Verfahrenstechnik sollen hierzu Hinweise und Anregungen geben.
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 13-17 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 11-12 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Zur Metallbestimmung kann man Geräte benutzen, in denen der elektrische Strom innerhalb der Elektrolysierzelle selbst entsteht. Das Verfahren hat gegenüber dem mit von außen zugeführten Strom den Vorteil, daß die Platinanode und die äußere Stromquelle entfallen und die Abscheidung rascher verläuft.
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 8-11 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Zur Berechnung der relativen Flüchtigkeit zweier Komponenten eines Gemisches werden einfache Formeln angegeben. Ihre Gültigkeit ist beschränkt auf Gemische aus normalen, ähnlichen Verbindungen im Bereich von 10-800 Torr. So wird die Berechnung von Gleichgewichtskurven normaler Gemische möglich, wie sie sich im Steinkohlenteer finden.
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 18-20 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 20-22 
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    Keywords: Chemistry ; Industrial Chemistry
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 22-22 
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 22-22 
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 22-22 
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    Keywords: Chemistry ; Industrial Chemistry
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 22-22 
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 23-25 
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    Keywords: Chemistry ; Industrial Chemistry
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 25-26 
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    Keywords: Chemistry ; Industrial Chemistry
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 26-26 
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    Keywords: Chemistry ; Industrial Chemistry
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 26-26 
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 27-28 
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    Keywords: Chemistry ; Industrial Chemistry
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 28-30 
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 33-34 
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 41-44 
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 35-37 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Eine kürzlich erschienene sehr umfangreiche Übersicht über die neuerdings im Apparatebau der USA bevorzugten Werkstoffe aus Stählen, NE-Metallen, Kunststoffen, Gummi, Keramik enthält außer einem die Entwicklung des letzten Jahrzents beschreibenden Textteil ein Tabellenwerk mit den wichtigsten mechanischen, thermischen, korrosionschemischen u. a. Werten von fast 100 Werkstoffen, ferner eine umfangreiche Literaturübersicht. Nachstehend wird auszugsweise über solche Entwicklungen bei NE-Metallen und keramischen Werkstoffen berichtet, die für uns neu und interessant erscheinen.
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 39-40 
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    Keywords: Chemistry ; Industrial Chemistry
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    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Das Verfahren beruht auf der Mikrosauerstoff-Bestimmung, die wir in Weiterentwicklung des Verfahrens von Schütze 1938-39 in Leverkusen ausgearbeitet haben. Es ermöglicht größere Genauigkeiten als die bisherigen Verfahren.
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 37-38 
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    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: In einer Tabelle werden die Umrechnungsfaktoren zusammengestellt, mit denen man den Inhali liegender Behälter mit kugeligen Anschlußflächen rasch berechnen kann.
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    Chemie Ingenieur Technik - CIT 22 (1950), S. 44-46 
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    Notes: Die Wärmeleitfähigkeit von wäßrigen Lösungen von Natrium- und Kaliumhydroxyd wurde mit einem stationären Zylinderverfahren in Abhängigkeit von der Konzentration und Temperatur gemessen. Die Ergebnisse wurden auf Grund einer Betrachtung der Wirkung der verschiedenen gelösten lonen auf die Wärmeleitfähigkeit des Wassers einheitlich ausgewertet und in Tabellen dargestellt.
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    Notes: Es wird ein pH-Meßgerät hoher Empfindlichkeit beschrieben, das den pH-Wert direkt anzeigt. Meßelektrode und Anzeigegerät sind in ihren elektrischen Eigenschaften aufeinander abgestimmt und zu praktischen, einfachen und geschlossenen Baukörpern zusammengefaßt.
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    Notes: In Behältern und Apparaten, in die ein Flüssigkeits- oder Gasgemisch einströmt, das eine andere Zusammensetzung hat als das darin befindliche Gemisch, treten bei gleichzeitiger kontinuierlicher Abführung eines Teiles des so gebildeten neuen Gemisches zeitliche Konzentrationsänderungen auf; da sie mathematisch nicht einfach zu erfassen sind, werden im folgenden für den Betriebsmann allgemein verwendbare Gleichungen abgeleitet und für die technisch wichtigsten Fälle Nomogramme gebracht.
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    Notes: In der Versorgung mit Nichteisenmetallen ist Deutschland teilweise vom Ausland abhängig. Der bis 1952 laufende Marshallplan sichert jedoch die Bedarfsdeckung für die Verbraucher, insbesondere die Apparatebauer. Auch für die Zeit nachher sind keine größeren Schwierigkeiten zu erwarten, da die Ausfuhr von Fertigerzeugnissen ein Mehrfaches an Devisen erbringen dürfte, als für die Metallimporte benötigt wird.
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    Notes: Es wird eine allgemeine Definition des Wirkungsgrades thermodynamischer Maschinen und Verfahren vorgeschlagen, beruhend auf dem Begriff der Arbeitsfähigkeit, der sich aus dem I. und II. Hauptsatz ableiten läßt. An mehreren Beispielen wird gezeigt, wie sich daraus durch Spezialisierung die Wirkungsgradbegriffe für beliebige Prozesse eindeutig ableiten lassen. Die Arbeitsfähigkeit erweist sich ferner als der gegebene Maßstab zur bildlichen Darstellung des Energieflusses in thermodynamischen Verfahren.
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    Notes: Es werden die gebräuchlichsten Hochdruck- und Niederdruck-Quecksilberdampflampen beschrieben. Die Verwendung spezieller Konstruktionen in der chemischen Industrie, in pharmazeutischen und lebensmittel - chemischen Betrieben (insbesondere zur Luftentkeimung) wird eingehend behandelt1.
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    Notes: Es wird ein neues Tonerdeverfahren beschrieben, das auf der Auslaugung des Bauxites in ruhendem Zustande beruht. Es werden hierbei nur klare Laugen transportiert, die einen rationellen Wärmeaustausch ermöglichen. Außerdem läßt sich über die Hälfte mehr Tonerde als bei den bisherigen Verfahren im gleichen Volumen lösen. Der Verbrauch an Wärme beträgt weniger als die Hälfte der alten Verfahren.
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