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  • Kinetics  (64)
  • Genes  (42)
  • Species Specificity  (35)
  • American Association for the Advancement of Science (AAAS)  (138)
  • Annual Reviews
  • Nature Publishing Group
  • 1980-1984  (138)
  • 1935-1939
  • 1982  (72)
  • 1980  (66)
  • 1939
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (138)
  • Annual Reviews
  • Nature Publishing Group
  • Springer  (14)
  • Wiley-Blackwell  (1)
Years
  • 1980-1984  (138)
  • 1935-1939
Year
  • 101
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    The molecules that initiate cardiac hypertrophy are not species-specific (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-30
    Description: Extracts from hypertrophying dog hearts perfused through isolated rat hearts increase the synthesis of messenger RNA and initiate hypertrophy in the treated hearts. Total RNA extracted from experimental and control hearts was translated in vitro and hybridized with polyuridylate. Synthesis of protein and polyadenylate-containing RNA was greater in rat hearts perfused with extracts of hypertrophying dog hearts than in control hearts. The results demonstrate that molecules from hypertrophying dog hearts are not species-specific since they are effective in stimulating transcription of messenger RNA in rat hearts as well as in dog hearts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hammond, G L -- Lai, Y K -- Markert, C L -- HL 25699-01/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 30;216(4545):529-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6461921" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cardiomegaly ; Dogs ; Muscle Proteins/*biosynthesis ; Protein Biosynthesis/drug effects ; RNA, Messenger/metabolism ; Rats ; Species Specificity ; Transcription, Genetic/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 102
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    The human genes for S-adenosylhomocysteine hydrolase and adenosine deaminase are syntenic on chromosome 20 (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-14
    Description: Human-Chinese hamster cell hybrids and a monoclonal antibody to human S-adenosylhomocysteine hydrolase were used to identify chromosome 20 as the location of the human gene for this enzyme. The gene for adenosine deaminase had previously been mapped to this chromosome. The activity of S-adenosylhomocysteine hydrolase is dependent in vivo on that of adenosine deaminase, since the substrates for the deaminase, adenosine and deoxyadenosine, respectively, inhibit and inactivate S-adenosylhomocysteine hydrolase in genetic or drug-induced adenosine deaminase deficiency. This functional dependence and the likelihood that S-adenosylhomocysteine hydrolase, a eukaryotic enzyme, arose later than adenosine deaminase, which occurs in prokaryotes as well as eukaryotes, suggest that the occurrence of their genes on the same chromosome may have evolutionary significance. In addition, the unusual capacity of S-adenosylhomocysteine hydrolase to form stable complexes with adenosine and its cofactor, nicotinamide adenine dinucleotide, suggest that evolution of its gene may have involved recombination of a portion of the adenosine deaminase gene with an adenine nucleotide domain-coding sequence of another preexisting gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hershfield, M S -- Francke, U -- AM 00424/AM/NIADDK NIH HHS/ -- AM 20902/AM/NIADDK NIH HHS/ -- GM 26105/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 May 14;216(4547):739-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079734" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Deaminase/*genetics ; Adenosylhomocysteinase ; Antibodies, Monoclonal ; Biological Evolution ; *Chromosomes, Human, 21-22 and Y ; Genes ; Genetic Linkage ; Humans ; Hydrolases/*genetics/immunology ; Nucleoside Deaminases/*genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
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    Are ions involved in the gating of calcium channels? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current activation, surface charge effects, or incomplete space clamping. The findings indicate participation of the divalent cations in the voltage-driven calcium channel gating process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saimi, Y -- Kung, C -- GM22714/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):153-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289432" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Barium/metabolism ; Calcium/*metabolism ; Cell Membrane/physiopathology ; Ion Channels/*metabolism ; Kinetics ; Membrane Potentials ; Paramecium/*physiology ; Strontium/metabolism
    Print ISSN: 0036-8075
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  • 104
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    Monkey and human pictorial memory scanning (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: A rhesus monkey accurately recognized pictures in a Sternberg memory scanning experiment. When the monkey was tested with pictures that were reused during the same session, the monkey's performance was nearly identical to that of a human subject; this result demonstrates the monkeys are capable of some of the short-term retrieval mechanisms of humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sands, S F -- Wright, A A -- EY-01256/EY/NEI NIH HHS/ -- MH35202/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1333-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079768" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Female ; Humans ; Macaca mulatta ; Male ; Memory/*physiology ; Species Specificity ; Time Factors ; *Visual Perception
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 105
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    beta, gamma-Peroxy analogs of adenosine and guanosine triphosphate: synthesis and biological activity (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: Extended analogs of adenosine triphosphate (ATP) and guanosine triphosphate (GTP), in which a peroxide bridge replaces the terminal bridge-oxygen of the triphosphate chain, have been synthesized. The ability of beta, gamma-peroxy-ATP to inhibit or substitute for ATP in representative enzyme systems and that of beta, gamma-peroxy-GTP, for FTP in protein synthesis was tested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosendahl, M S -- Leonard, N J -- GM-05829/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):81-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053563" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/*analogs & derivatives/chemical synthesis/metabolism ; Guanosine Triphosphate/*analogs & derivatives/chemical synthesis/metabolism ; Kinetics ; Peroxides ; Protein Biosynthesis/drug effects ; Structure-Activity Relationship
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  • 106
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    Genetic mapping in mammals: chromosome map of domestic cat (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-16
    Description: A genetic map of 31 biochemical loci located on 17 feline syntenic (linkage) groups has been derived by somatic cell genetic analysis of cat-rodent hybrids. Most of these syntenic groups have been assigned to one of the 19 feline chromosomes. Comparative linkage analysis of the feline biochemical loci and homologous human loci revealed considerable conservation of linkage associations between the primates and the Felidae (order Carnivora). Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, S J -- Nash, W G -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):257-65.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063884" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Cats/*genetics ; Chromosome Mapping ; Chromosomes/*ultrastructure ; Enzymes/genetics ; Genes ; Genetic Linkage ; Hybrid Cells/physiology ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 107
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    Clustering of leukocyte and fibroblast interferon genes of human chromosome 9 (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-22
    Description: At least ten leukocyte interferon genes and the single known fibroblast interferon gene have been localized on the pter leads to q12 region of human chromosome 9. Gene mapping was accomplished by blot hybridization of cloned interferon complementary DNA to DNA from human-mouse cell hybrids with a translocation involving human chromosome 9. Supporting evidence suggests these genes are clustered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shows, T B -- Sakaguchi, A Y -- Naylor, S L -- Goedell, D V -- Lawn, R M -- GM 20454/GM/NIGMS NIH HHS/ -- HD 05196/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 22;218(4570):373-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6181564" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Mapping ; *Chromosomes, Human, 6-12 and X ; Genes ; Genetic Linkage ; Humans ; Hybrid Cells ; Interferons/*genetics
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  • 108
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    Tritiated imipramine binding sites are decreased in the frontal cortex of suicides (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: Binding characteristics of tritiated imipramine were determined in the frontal cortex of suicides and well-matched controls. Maximal binding was significantly lower in brains from the suicides. This finding is consistent with reports of decreased tritiated imipramine binding in the platelets of patients diagnosed as having a major affective disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, M -- Virgilio, J -- Gershon, S -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1337-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079769" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Carrier Proteins ; Cerebral Cortex/*metabolism ; Humans ; Imipramine/*metabolism ; Kinetics ; Middle Aged ; Receptors, Drug/*metabolism ; Reference Values ; *Suicide ; Tritium
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  • 109
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    Biotin enhances guanylate cyclase activity (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: Biotin and its analog, (+)-biotin-p-nitrophenyl ester enhanced guanylate cyclase activity two- to threefold in rat liver, kidney, colon, cerebellum, and heart. Dose-response relationships revealed that at concentrations as low as 1 micromolar, both biotin and its analog caused maximal augmentation of guanylate cyclase activity. These data suggest a role for the activation of guanylate cyclase in the mechanism of action of this vitamin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vesely, D L -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6123152" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotin/analogs & derivatives/*pharmacology ; Cerebellum/enzymology ; Colon/enzymology ; Guanylate Cyclase/*metabolism ; Kidney/enzymology ; Kinetics ; Liver/enzymology ; Myocardium/enzymology ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
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  • 110
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    Insulin receptors in hepatocytes: postreceptor events mediate down regulation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-28
    Description: Down regulation of the insulin receptor of primary cultures of rat hepatocytes occurs in the presence of insulin and several agents with insulin-like activity, which act through or distal to the insulin receptor. These findings indicate that the interaction of insulin with its specific binding site is not in itself sufficient to down-regulate this receptor and that one or more steps subsequent to this interaction are necessary. Thus, down regulation may be a complex biological response to insulin, and if a cell were resistant to this effect of insulin, our data may explain how target cells from a patient or animal can have a normal number of receptors in the presence of increased concentrations of circulating insulin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caro, J F -- Amatruda, J M -- AM 00366/AM/NIADDK NIH HHS/ -- AM 20948/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 28;210(4473):1029-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7001632" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Insulin/metabolism ; Kinetics ; Liver/*metabolism ; Male ; Peroxides/pharmacology ; Rats ; Receptor, Insulin/drug effects/immunology/*metabolism ; Spermine/pharmacology ; Vitamin K/pharmacology
    Print ISSN: 0036-8075
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  • 111
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    Identification of mosquitoes of Anopheles gambiae species complex A and B by analysis of cuticular components (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-07
    Description: Two important vectors of malaria in Africa, Anopheles gambiae and Anopheles arabiensis (Diptera: Culicidae), often occur sympatrically and cannot be distinguished morphologically. A chemical method was developed to identify individual laboratory-reared adult males or females of either species by extraction and analysis of cuticular components with gas chromatography. Statistically significant differences were seen between species when selected pairs of peaks were compared.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlson, D A -- Service, M W -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355276" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/analysis/*classification ; Chromatography, Gas ; Female ; Lipids/analysis ; Male ; Paraffin/analysis ; Sex Factors ; Skin/analysis ; Species Specificity
    Print ISSN: 0036-8075
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  • 112
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    Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-27
    Description: Mice of two different strains were injected subcutaneously with spontaneously metastasizing syngeneic melanomas. After 4 to 6 weeks, the local tumors were removed and, 3 days after surgery, treatment of the metastases was initiated. The treatment consisted of intravenous injections of liposomes containing lymphokines or control supernatant fluids. Liposomes were injected twice weekly for 3 weeks, and the mice were killed 2 weeks later. Seventy-three percent of the mice injected with liposomes containing lymphokines were free of metastases, whereas only 10 percent of the mice treated with control liposomes were tumor-free. These experiments suggest that this form of therapy may provide a valuable addition to the more conventional approaches to the eradication of cancer metastases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fidler, I J -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1469-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384789" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Liposomes/*therapeutic use ; Lymphokines/*therapeutic use ; Melanoma/*drug therapy ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; *Neoplasm Metastasis ; Neoplasms, Experimental/drug therapy ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 113
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    1 alpha, 25-Dihydroxyvitamin D3 nuclear receptors in pituitary (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-12
    Description: Specific binding of 1 alpha,25-dihydroxyvitamin D(3) was found in nuclear and cytosol fractions of the bovine pituitary. For nuclear binding. the dissociation constant was 0.1 namomole per liter, and maximum binding was 104 femtomoles per milligram of protein. In competition studies, 25-hydroxyvitamin D(3) was 300 times weaker than 1 alpha,25-dihydroxyvitamin D(3). The existence of high-affinity sites supports a physiologic role for 1 alpha,25-dihydroxyvitamin D(3) in the pituitary.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelbard, H A -- Stern, P H -- U'Prichard, D C -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1247-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250221" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/metabolism ; Cattle ; Cell Nucleus/metabolism ; Cholecalciferol/*metabolism ; Cytosol/metabolism ; Dihydroxycholecalciferols/*metabolism ; Hydroxycholecalciferols/*metabolism ; Kinetics ; Pituitary Gland/*metabolism/ultrastructure ; Receptors, Drug/*metabolism
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  • 114
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    Strain dependence of the antiproliferative action of interferon on murine erythroid precursors (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: Electrophoretically pure mouse interferon inhibits erythropoietin-dependent proliferation of committed erythroid precursors (CFU-E) obtained either from adult mouse bone marrow or from 14-day fetal mouse livers. The degree of inhibition is significantly influenced by the genotype of the cell donor; about ten times as much interferon is required to inhibit proliferation of CFU-E from C57BL/6 than is needed for comparable inhibition of CFU-E from BALB/c or Swiss mice. These strain-dependent results point to the existence of genes that influence the degree of the inhibitory effect of interferon on cell multiplication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallien-Lartigue, O -- Carrez, D -- De Maeyer, E -- De Maeyer-Guignard, J -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):292-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6155700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow/drug effects/*physiology ; Cell Division/drug effects ; Embryo, Mammalian ; Erythropoiesis/*drug effects ; Female ; Interferons/*pharmacology ; Liver/drug effects/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Species Specificity
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  • 115
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    Human gene treatment stirs new debate (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- Wade, N -- New York, N.Y. -- Science. 1980 Oct;210(4468):407.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6933693" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/therapy ; Bone Marrow Cells ; Ethics Committees, Research ; Genes ; Genetic Engineering/*methods ; Globins/genetics ; Humans ; Thalassemia/genetics/*therapy ; Thymidine Kinase/genetics
    Print ISSN: 0036-8075
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  • 116
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    Time: a new parameter for kinetic measurements in flow cytometry (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: The measure of time was used as an additional parameter on an existing flow cytometer to study the kinetics of enzyme activities and cell-stain interactions. By correlating all fluorescent signals from single cells with time, the dynamics of a reaction can be followed for several minutes. This advanced application of flow cytometry is easily implemented and can be incorporated into any flow cytometer that has two-parameter analysis capability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, J C -- Swartzendruber, D E -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):199-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6153131" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured/enzymology ; Computers ; Cricetinae ; *Cytological Techniques ; DNA/metabolism ; Esterases/metabolism ; Kinetics ; Mice ; Spectrometry, Fluorescence/methods ; Staining and Labeling
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  • 117
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    Interferon congress highlights (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1980 Nov 28;210(4473):998.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159687" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents ; Congresses as Topic ; DNA, Recombinant ; Genes ; Humans ; *Interferons/genetics/therapeutic use
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  • 118
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    Genetics and the origin of a vector population: Aedes aegypti, a case study (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-20
    Description: Thirty-four population samples representing the worldwide distribution of the mosquito Aedes aegypti were analyzed for variation at 19 to 22 enzyme-coding genes. A multivariate discriminant analysis revealed that the genetic differences among populations in six geographic regions and between two subspecies enable one to determine the regional origin of a population. Such studies of population genetics may have quite general applicability in studying vector-borne diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Powell, J R -- Tabachnick, W J -- Arnold, J -- New York, N.Y. -- Science. 1980 Jun 20;208(4450):1385-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375945" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/*genetics ; Alleles ; Animals ; Enzymes/genetics ; Gene Frequency ; Insect Vectors/*genetics ; Species Specificity
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    Effective pulmonary ventilation with small-volume oscillations at high frequency (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-01
    Description: At high oscillation frequencies (4 to 30 hertz), effective alveolar ventilation can be achieved with tidal volumes much smaller than the anatomic dead space. An explanation of this phenomenon is given in terms of the combined effects of diffusion and convection and in terms of data consistent with the hypothesis. Theory and experimental results both show that the significant variable determining the effectiveness of gas exchange is the amplitude of the oscillatory flow rate independent of the individual values of frequency and stroke volume.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slutsky, A S -- Drazen, F M -- Ingram, R H Jr -- Kamm, R D -- Shapiro, A H -- Fredberg, J J -- Loring, S H -- Lehr, J -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):609-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6771872" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Dioxide/metabolism ; Diffusion ; Dogs ; Kinetics ; Mathematics ; Oscillometry ; Pulmonary Alveoli/*physiology ; *Respiration
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    Endocytotic sucrose uptake in Amoeba proteus induced with the calcium ionophore A23187 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: The calcium ionophore A23187 brings about an influx of calcium and uptake of sucrose by endocytosis in Amoeba proteus. The amount of endocytotic sucrose uptake elicited by the ionophore depends upon the external calcium ion concentration. Calcium ion movements may serve to couple the surface phase of endocytosis with cytoplasmic uptake of the endocytotic inducer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prusch, R D -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):691-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6771873" target="_blank"〉PubMed〈/a〉
    Keywords: Amoeba/drug effects/*metabolism ; Animals ; Anti-Bacterial Agents/*pharmacology ; Biological Transport/drug effects ; Calcimycin/*pharmacology ; Calcium/metabolism ; Endocytosis/*drug effects ; Kinetics ; Sucrose/*metabolism
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    At least three human type alpha interferons: structure of alpha 2 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: The sequence of a human leukocyte-derived complementary DNA (cDNA), Hif-2h, which directs the formation in Escherichia coli of a polypeptide, IFN-alpha 1, with interferon (IFN) activity has been described. A second IFN cDNA, Hif-SN206, which also elicits synthesis of a biologically active IFN, IFN-alpha 2, is described in this article. Whereas IFN-alpha 2 is twice as active on human as on bovine cells, IFN-alpha 1 is 10 to 20 times more active on bovine than on human cells. As deduced from the cDNA's, the messenger RNA's for the two IFN's differ in length and in 20 percent of the nucleotides; the mature IFN polypeptides differ in 17 percent of the amino acids. Both IFN-alpha 1 and IFN-alpha 2 differ from the lymphoblastoid IFN described by others. Therefore, at least three different IFN-alpha genes are expressed in man; studies on genomic DNA reveal the presence of at least eight IFN-related genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streuli, M -- Nagata, S -- Weissmann, C -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1343-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6158094" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; DNA, Recombinant ; Escherichia coli/genetics ; Genes ; Humans ; *Interferons/genetics ; Leukocytes ; Lymphocytes ; Mice ; RNA, Messenger/genetics ; Structure-Activity Relationship
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    Niemann-Pick disease: a genetic model in Siamese cats (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-27
    Description: Three Siamese cats were found to have a progressive neurological disease that became obvious when they were 4 to 5 months of age. Their brains contained an excess of GM2 and GM3 gangliosides, and their livers a nine- to tenfold excess of sphingomyelin and cholesterol. A total deficiency of lysosomal (pH 5.0) sphingomyelinase was found in the leukocytes, liver, and brain of the cats, although the activity of the microsomal (pH 7.4, magnesium-dependent) sphingomyelinase was normal in brain. These cats appear to have a genetic disease identical to Niemann-Pick disease type A.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wenger, D A -- Sattler, M -- Kudoh, T -- Snyder, S P -- Kingston, R S -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1471-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189903" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/enzymology ; Brain Chemistry ; Cat Diseases/enzymology/*genetics ; Cats ; *Disease Models, Animal ; Gangliosides/analysis ; Humans ; Kinetics ; Liver/analysis ; Niemann-Pick Diseases/enzymology/*genetics ; Phospholipids/analysis ; Sphingomyelin Phosphodiesterase/analysis
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    Steps toward computer analysis of nucleotide sequences (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: Advances in recombinant DNA technology have allowed the isolation of large numbers of biologically interesting fragments of DNA. Concomitant improvements in methods for nucleic acid sequencing have led many investigators to characterize their clones by sequencing them. This has resulted in the accumulation of such large amounts of sequence data that computer-assisted methods, with programs directed toward the manipulation of nucleic acid sequences, have become indispensable during the collection and analysis of that data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gingeras, T R -- Roberts, R J -- 1R01-CA27275-01/CA/NCI NIH HHS/ -- CA 13106/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1322-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6251542" target="_blank"〉PubMed〈/a〉
    Keywords: Autoanalysis ; *Base Sequence ; *Computers ; DNA Restriction Enzymes ; DNA, Viral ; Genes ; Hydrogen Bonding ; Nucleic Acid Conformation ; Nucleic Acid Precursors/genetics ; *Nucleic Acids ; RNA, Transfer/genetics ; Substrate Specificity
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    Dexamethasone fails to suppress beta-endorphin plasma concentrations in humans and rhesus monkeys (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: In humans and rhesus monkeys, dexamethasone decreased concentrations of plasma cortisol but did not alter circulating beta-endorphin immunoreactivity. Contrary to current theory suggesting that pituitary beta-endorphin and adrenocorticotropic hormone are controlled by identical regulatory mechanisms for synthesis and release, our evidence suggests that in higher primates the established glucocorticoid feedback mechanism for the adrenocorticotropic hormone-cortisol system does not regulate beta-endorphin secretion in the same way.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalin, N H -- Risch, S C -- Cohen, R M -- Insel, T -- Murphy, D L -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):827-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250217" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Adult ; Animals ; Dexamethasone/*pharmacology ; Endorphins/*blood/secretion ; Feedback ; Female ; Haplorhini ; Humans ; Hydrocortisone/blood ; Macaca mulatta ; Male ; Pituitary Gland, Anterior/secretion ; Protein Precursors/metabolism ; Species Specificity ; Stress, Physiological/blood
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    Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-21
    Description: In rhesus monkeys with hypothalamic lesions (which appear to abolish the endogenous production of gonadotropin-releasing hormone), normal ovulatory mestrual cycles were reestablished by an unvarying, long-term replacement regimen consisting of one intravenous pulse of synthetic gonadotropic-releasing hormone per hour. This finding is in accord with the hypothesis that the pattern of pituitary gonadotropin secretion throughout the menstrual cycle (basal secretion interrupted, once every 28 days on the average, by a preovulatory surge) is not directed by alterations in hypothalamic gonadotropin-releasing hormone secretion but by the ebb and flow of ovarian estrogens acting directly on the pituitary gland.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knobil, E -- Plant, T M -- Wildt, L -- Belchetz, P E -- Marshall, G -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1371-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6766566" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Estradiol/pharmacology ; Female ; Gonadotropin-Releasing Hormone/*physiology ; Haplorhini ; Hypothalamus/*physiology ; Macaca/*physiology ; Macaca mulatta/*physiology ; *Menstruation/drug effects ; Pituitary Gland/physiology ; Species Specificity
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    Thalassemias: models of genetic diseases (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):300-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423190" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Deletion ; Gene Expression Regulation ; Genes ; Globins/*genetics ; Humans ; Models, Genetic ; Nucleic Acid Precursors/genetics ; RNA, Messenger/genetics ; Thalassemia/blood/*genetics ; Transcription, Genetic
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    Sodium-calcium exchange in rabbit heart muscle cells: direct measurement of sarcoplasmic Ca2+ activity (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-08
    Description: Calcium ion-selective microelectrodes made with Simon's neutral carrier were used to measure simultaneously sarcoplasmic Ca2+ activity (aiCa) and resting tension (Tr) of rabbit ventricular muscle during reduction and restoration of external sodium ion concentration, [Na]0. Under the same experimental conditions the change in contractile tension (Ta) also measured. In resting muscle the aiCa was 38 +/- 17 nanomolar (mean +/- standard deviation; N = 10). The reduction of [Na]O from 153 to 20 millimolar led to about a threefold increase in aiCa with parallel increases in Tr and Ta. The time course of the change in aiCa was similar to that of the changes in Tr and Ta. The results are consistent with an important role of the sodium-calcium exchange system for regulating sarcoplasmic Ca2+ activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, C O -- Uhm, D Y -- Dresdner, K -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):699-701.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394527" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Heart Ventricles/metabolism ; Kinetics ; Membrane Potentials/drug effects ; Microelectrodes ; Myocardium/*metabolism ; Rabbits ; Sarcoplasmic Reticulum/drug effects/*metabolism ; Sodium/*metabolism/pharmacology
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    Neuronal control of acetylcholine receptor turnover rate at a vertebrate neuromuscular junction (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-10-31
    Description: The turnover rate of acetylcholine receptors at neuromuscular junctions in mice increases progressively after denervation and, after 15 days, reaches a half-time of 30 z 5 hours. Denervation thus causes the clustered junctional acetylcholine receptors to assume the rapid turnover characteristic of extrajunctional receptors before innervation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levitt, T A -- Loring, R H -- Salpeter, M M -- NS 09315-10/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):550-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423205" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bungarotoxins/metabolism ; Kinetics ; Mice ; Motor Neurons/*physiology ; Muscle Denervation ; Neuromuscular Junction/*metabolism ; Receptors, Cholinergic/*metabolism ; Receptors, Nicotinic/metabolism
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    Mouse globin system: a functional and evolutionary analysis (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-09-19
    Description: Structural and functional analysis of the mouse alpha-globin and beta-globin genes reveals that the globin genes are encoded in discontinous bits of coding information and that each gene locus is much more complex than was originally supposed. Each seems to consist of an array of several authentic genes as well as several apparently inactive pseudogenes. Comparison of the sequences of some of these genes to one another indicates that chromosomal DNA is a dynamic structure. Flanking and intervening sequences change in two ways: quickly, by duplication and extensive insertions and deletions, and slowly, by point mutation. Active coding sequences are usually limited to the slower mode of evolution. In addition to identifying fast and slow modes of evolution, it has also been possible to test the function of several signals that surround these genes and to identify those that appear to play a role in gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leder, P -- Hansen, J N -- Konkel, D -- Leder, A -- Nishioka, Y -- Talkington, C -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1336-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7414319" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Biological Evolution ; Genes ; Globins/*genetics ; Mice ; Nucleic Acid Hybridization ; Nucleic Acid Precursors/genetics ; RNA, Messenger/genetics/metabolism
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    Survival of Escherichia coli host-vector systems in the mammalian intestine (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-18
    Description: Survival in the mouse and human intestine of Escherichia coli host-vector systems used and proposed for recombinant DNA technology was assessed. There was no detectable survival of severely disabled E. coli K12 strain X1776 in mice or in human subjects 24 hours after ingestion. The same strain bearing the plasmid pBR322, however, was recovered from human subjects for 4 days in amounts of six organisms for every million ingested. Nondisabled E. coli K12 strain X1666, with or without pBR322, survived in 10(4)-fold greater numbers and for 2 days longer, with better recovery of the plasmid-containing derivative. Although the plasmid-bearing strains were recovered for longer periods, no intestinal colonization was noted. Despite the presence of pBR322 for a maximum of 6 days in the human intestine, there was no evidence that it was transferred from either bacterial host to endogenous aerobic fecal bacteria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, S B -- Marshall, B -- Rowse-Eagle, D -- Onderdonk, A -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):391-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6992276" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Recombinant/metabolism ; Escherichia coli/*physiology ; Humans ; Intestines/*microbiology ; Mice ; Plasmids ; Species Specificity
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    Lactate dehydrogenases of Atlantic hagfish: physiological and evolutionary implications of a primitive heart isozyme (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-15
    Description: Isozymes of lactate dehydrogenase from heart and muscle of Atlantic hagfish show less functional divergence than those from other fishes and higher vertebrates. The enzyme from hagfish heart (B4) displays a higher Michaelis constant for pyruvate and lower substrate inhibition at moderate pyruvate concentrations than heart isozymes from other species. These properties support the hypothesis that the ancestral vertebrate lactate dehydrogenase was a muscle (A4)-type enzyme and also suggest a role for the B4 enzyme in the unusual physiology of hagfish cardiac tissue which functions under sustained hypoxic conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sidell, B D -- Beland, K F -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):769-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352286" target="_blank"〉PubMed〈/a〉
    Keywords: Anaerobiosis ; Animals ; *Biological Evolution ; Energy Metabolism ; Fishes/genetics/*physiology ; Genes ; Isoenzymes ; Kinetics ; L-Lactate Dehydrogenase/*genetics/metabolism ; Muscles/*enzymology ; Myocardium/enzymology ; Pyruvates/metabolism
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    Mammoth albumin (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-11
    Description: Serum albumin was detected immunologically in muscle from a mammoth that died about 40,000 years ago. Rabbits injected with ground mammoth muscle produced antibodies that react strongly with elephant albumin, weakly with sea cow albumin, and still more weakly or not at all with other mammalian albumins. Since elephant albumin elicited antibodies with the same specificity, some of the surviving mammoth albumin molecules evidently have antigenic sites identical to those on native elephant albumin. Much of the mammoth albumin has, however, undergone postmortem change. The small amount of soluble albumin extractable from mammoth muscle is heterogeneous in size, charge, and antigenic properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prager, E M -- Wilson, A C -- Lowenstein, J M -- Sarich, V M -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):287-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6155699" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Elephants/*blood ; Epitopes ; *Fossils ; History, Ancient ; Immunodiffusion ; Muscles/*analysis ; *Paleontology ; Rabbits/immunology ; Serum Albumin/*analysis/immunology ; Species Specificity
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    Bone cancer from radium: canine dose response explains data for mice and humans (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-04-04
    Description: Analysis of lifetime studies of 243 beagles with skeletal burdens of radium-226 shows that the distribution of bone cancers clusters about a linear function of the logarithms of radiation dose rate to the skeleton and time from exposure until death. Similar relations displaced by species-dependent response ratios also provide satisfactory descriptions of the reported data on deaths from primary bone cancers in people and mice exposed to radium-226. The median cumulative doses (or times) leading to death from bone tumors are 2.9 times larger for dogs than for mice and 3.6 times larger for people than for dogs. These response ratios are well correlated with the normal life expectancies. The cumulative radiation dose required to give significant risk of bone cancer is found to be much less at lower dose rates than at higher rates, but the time required for the tumors to be manifested is longer. At low dose rates, this time exceeds the normal life-span and appears as a practical threshold, which for bone cancer is estimated to occur at an average cumulative radiation dose to the skeleton of about 50 to 110 rads for the three species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raabe, O G -- Book, S A -- Parks, N J -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):61-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361106" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Neoplasms/*etiology/mortality ; *Disease Models, Animal ; *Dogs ; *Dose-Response Relationship, Radiation ; Humans ; Mice ; Neoplasms, Radiation-Induced/*etiology ; Radium/*adverse effects ; Species Specificity
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    Sodium-calcium exchange activity generates a current in cardiac membrane vesicles (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-27
    Description: Sarcolemmal membrane vesicles isolated from canine ventricular tissue accumulate calcium through the sodium-calcium exchange system when an outwardly directed sodium gradient is generated across the vesicle membrane. Moreover, calcium uptake under these conditions is accompanied by the transient accumulation of the lipophilic cation tetraphenylphosphonium. Since the distribution of tetraphenylphosphonium across biological membranes reflects the magnitude and direction of transmembrane potential differences and the characteristics of the transient accumulation of this cation closely resemble those of sodium-calcium exchange activity, it is concluded that a membrane potential, interior negative, is produced during calcium accumulation through the exchange system. Thus, the operation of the sodium-calcium exchange system generates a current in cardiac membrane vesicles, suggesting that three or more sodium ions exchange for each calcium ion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reeves, J P -- Sutko, J L -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1461-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384788" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport, Active/drug effects ; Calcium/*metabolism ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology ; Cell Membrane/drug effects/*metabolism ; Heart/*physiology ; Kinetics ; Membrane Potentials/drug effects ; Myocardium/*metabolism ; Onium Compounds/metabolism ; *Organophosphorus Compounds ; Sodium/*metabolism ; Valinomycin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 135
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    N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: The chemotaxis of leukocytes appears to be initiated by the binding of chemotactic factors to the surface of these cells. N-Formylated peptides induce chemotaxis and lysosomal enzyme secretion of leukocytes; because these peptides are available in a purified radiolabeled form, they have been useful in the characterization of receptors for chemotactic factors. Equine polymorphonuclear leukocytes secrete lysosomal enzymes but do not exhibit chemotaxis in respone to the N-formylated peptides, even though they have a high-affinity cell surface receptor for these agents. The specificity of the equine receptor resembles the specificity of the receptor on chemotactically responsive leukocytes from other species. Equine polymorphonuclear leukocytes may thus be an excellent model for the study of the events that lead to a biological response following receptor occupancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyderman, R -- Pike, M C -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):493-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248959" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chemotaxis ; Horses ; Kinetics ; Leukocytes/*physiology/secretion ; Oligopeptides/blood/*physiology ; Receptors, Cell Surface/*physiology ; Receptors, Formyl Peptide ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 136
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    Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Theoharides, T C -- Sieghart, W -- Greengard, P -- Douglas, W W -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):80-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6153130" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Cromolyn Sodium/*pharmacology ; Histamine Release/*drug effects ; Kinetics ; Mast Cells/*drug effects/immunology/metabolism ; Molecular Weight ; Phosphoproteins/*metabolism ; Phosphorylation ; Rats ; p-Methoxy-N-methylphenethylamine/antagonists & inhibitors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 137
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    Energy requirement for nitrogen fixation in actinorhizal and legume root nodules (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The ratio of respiration to nitrogenase activity was measured in five species of actinorhizal root nodules and eight species of legume nodules. The two types of nodules could not be distinguished on the basis of this ratio; this evidence thus indicates that the energy cost of nitrogen fixation is similar for both.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tjepkema, J D -- Winship, L J -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):279-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384801" target="_blank"〉PubMed〈/a〉
    Keywords: Actinomycetales/metabolism ; Kinetics ; *Nitrogen Fixation ; Plants/*metabolism ; Rhizobium/metabolism ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 138
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    Cholecystokinin receptors in the brain: characterization and distribution (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-06
    Description: Specific cholecystokinin binding sites in particulate fractions of rat brain were measured with iodine 125-labeled Bolton-Hunter cholecystokinin, a cholecystokinin analog that has full biological activity. Binding was detected in brain regions known to contain immunoreactive cholecystokinin. Binding was saturable, reversible, of high affinity (dissociation constant, 1.7 x 10(-9) M), and was inhibited by cholecystokinin analogs but not by unrelated hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saito, A -- Sankaran, H -- Goldfine, I D -- Williams, J A -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1155-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246582" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Brain/*metabolism ; Brain Mapping ; Cerebral Cortex/metabolism ; Cholecystokinin/*metabolism ; Gastrins/metabolism ; Kinetics ; Male ; Olfactory Bulb/metabolism ; Pancreas/metabolism ; Rats ; Receptors, Cell Surface/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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