Publication Date:
1980-08-15
Description:
In humans and rhesus monkeys, dexamethasone decreased concentrations of plasma cortisol but did not alter circulating beta-endorphin immunoreactivity. Contrary to current theory suggesting that pituitary beta-endorphin and adrenocorticotropic hormone are controlled by identical regulatory mechanisms for synthesis and release, our evidence suggests that in higher primates the established glucocorticoid feedback mechanism for the adrenocorticotropic hormone-cortisol system does not regulate beta-endorphin secretion in the same way.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalin, N H -- Risch, S C -- Cohen, R M -- Insel, T -- Murphy, D L -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):827-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250217" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenocorticotropic Hormone/secretion
;
Adult
;
Animals
;
Dexamethasone/*pharmacology
;
Endorphins/*blood/secretion
;
Feedback
;
Female
;
Haplorhini
;
Humans
;
Hydrocortisone/blood
;
Macaca mulatta
;
Male
;
Pituitary Gland, Anterior/secretion
;
Protein Precursors/metabolism
;
Species Specificity
;
Stress, Physiological/blood
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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