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  • United States  (1,666)
  • Rats  (634)
  • American Association for the Advancement of Science (AAAS)  (2,294)
  • American Chemical Society (ACS)
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  • 2005-2009  (1,214)
  • 1985-1989  (1,080)
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  • 101
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marder, Jenny -- New York, N.Y. -- Science. 2009 Nov 27;326(5957):1184. doi: 10.1126/science.326.5957.1184.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965448" target="_blank"〉PubMed〈/a〉
    Keywords: *Comparative Effectiveness Research ; Humans ; Male ; *Patient Education as Topic ; Prostatic Neoplasms/*therapy ; United States ; United States Agency for Healthcare Research and Quality
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 102
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2009 Oct 16;326(5951):383. doi: 10.1126/science.326_383.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833954" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; History, 20th Century ; History, 21st Century ; *Neurobiology/history ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schweitzer, Glenn -- New York, N.Y. -- Science. 2009 Jun 12;324(5933):1365. doi: 10.1126/science.1175097.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19520923" target="_blank"〉PubMed〈/a〉
    Keywords: *International Cooperation ; *National Academy of Sciences (U.S.) ; *Organizations ; Russia ; *Science ; *Technology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 104
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Town, Michael -- New York, N.Y. -- Science. 2009 Nov 20;326(5956):1062. doi: 10.1126/science.326.5956.1062-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965412" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Graduate/economics/*organization & administration ; *Faculty ; Fellowships and Scholarships ; Financing, Government ; Science/*education ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 105
    Publication Date: 2009-10-17
    Description: Cortical information processing is under state-dependent control of subcortical neuromodulatory systems. Although this modulatory effect is thought to be mediated mainly by slow nonsynaptic metabotropic receptors, other mechanisms, such as direct synaptic transmission, are possible. Yet, it is currently unknown if any such form of subcortical control exists. Here, we present direct evidence of a strong, spatiotemporally precise excitatory input from an ascending neuromodulatory center. Selective stimulation of serotonergic median raphe neurons produced a rapid activation of hippocampal interneurons. At the network level, this subcortical drive was manifested as a pattern of effective disynaptic GABAergic inhibition that spread throughout the circuit. This form of subcortical network regulation should be incorporated into current concepts of normal and pathological cortical function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Varga, Viktor -- Losonczy, Attila -- Zemelman, Boris V -- Borhegyi, Zsolt -- Nyiri, Gabor -- Domonkos, Andor -- Hangya, Balazs -- Holderith, Noemi -- Magee, Jeffrey C -- Freund, Tamas F -- HHMI55005608/Howard Hughes Medical Institute/ -- MH-54671/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):449-53. doi: 10.1126/science.1178307.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Experimental Medicine, Budapest 1083, Hungary. vargav@koki.hu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833972" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electric Stimulation ; Excitatory Postsynaptic Potentials ; Glutamic Acid/physiology ; Hippocampus/cytology/*physiology ; Inhibitory Postsynaptic Potentials ; Interneurons/*physiology ; Mice ; Neural Inhibition/physiology ; Neural Pathways/physiology ; Neurons, Afferent/*physiology ; Patch-Clamp Techniques ; Photic Stimulation ; Raphe Nuclei/cytology/*physiology ; Rats ; Rats, Sprague-Dawley ; Serotonin/*physiology ; Synapses/*physiology ; Synaptic Potentials/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 106
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2009 Mar 6;323(5919):1275. doi: 10.1126/science.323.5919.1275.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19264989" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States ; United States Government Agencies/*economics ; United States National Aeronautics and Space Administration/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 107
    Publication Date: 2009-05-30
    Description: The neural mechanisms underlying the transition from a drug-nondependent to a drug-dependent state remain elusive. Chronic exposure to drugs has been shown to increase brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) neurons. BDNF infusions into the VTA potentiate several behavioral effects of drugs, including psychomotor sensitization and cue-induced drug seeking. We found that a single infusion of BDNF into the VTA promotes a shift from a dopamine-independent to a dopamine-dependent opiate reward system, identical to that seen when an opiate-naive rat becomes dependent and withdrawn. This shift involves a switch in the gamma-aminobutyric acid type A (GABAA) receptors of VTA GABAergic neurons, from inhibitory to excitatory signaling.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913611/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913611/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vargas-Perez, Hector -- Ting-A Kee, Ryan -- Walton, Christine H -- Hansen, D Micah -- Razavi, Rozita -- Clarke, Laura -- Bufalino, Mary Rose -- Allison, David W -- Steffensen, Scott C -- van der Kooy, Derek -- AA13666/AA/NIAAA NIH HHS/ -- R01 AA013666/AA/NIAAA NIH HHS/ -- R01 AA013666-09/AA/NIAAA NIH HHS/ -- R01 AA020919/AA/NIAAA NIH HHS/ -- New York, N.Y. -- Science. 2009 Jun 26;324(5935):1732-4. doi: 10.1126/science.1168501. Epub 2009 May 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada. vargashector@yahoo.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478142" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bicuculline/pharmacology ; Brain-Derived Neurotrophic Factor/administration & ; dosage/genetics/*metabolism/*pharmacology ; Conditioning (Psychology) ; Dopamine/physiology ; Dopamine Antagonists/administration & dosage/pharmacology ; Flupenthixol/administration & dosage/pharmacology ; GABA Agonists/pharmacology ; GABA Antagonists/pharmacology ; Heroin Dependence/metabolism ; Male ; Morphine/administration & dosage ; Muscimol/pharmacology ; Opioid-Related Disorders/*metabolism ; RNA, Messenger/genetics/metabolism ; Rats ; Rats, Wistar ; Receptors, GABA-A/metabolism ; *Reward ; Signal Transduction ; Substance Withdrawal Syndrome/metabolism ; Ventral Tegmental Area/drug effects/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 108
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Travis, John -- New York, N.Y. -- Science. 2009 Sep 18;325(5947):1489. doi: 10.1126/science.325_1489a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19762619" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; Developing Countries ; Drug Industry ; Foundations ; Great Britain ; India ; *Public-Private Sector Partnerships ; United States ; *Vaccines
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 109
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schachman, Howard K -- Cassman, Marvin -- New York, N.Y. -- Science. 2009 Nov 13;326(5955):947. doi: 10.1126/science.1183756.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, QB3, Stanley Hall, University of California, Berkeley, CA 94720-3220, USA. howardschachman@berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965503" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; History, 20th Century ; History, 21st Century ; National Institute of General Medical Sciences (U.S.)/economics/organization & ; administration ; National Institutes of Health (U.S.)/economics/*organization & administration ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 110
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2009 Sep 11;325(5946):1324-5. doi: 10.1126/science.325_1324.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19745120" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; Humans ; *Persian Gulf Syndrome/etiology/metabolism ; *Research Support as Topic ; Texas ; United States ; United States Department of Veterans Affairs/*economics ; Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 111
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2009 Aug 7;325(5941):665. doi: 10.1126/science.325_665a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661395" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/blood/metabolism ; Azathioprine/*administration & dosage/blood/*metabolism ; *Blood Chemical Analysis ; Humans ; Patents as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 112
    Publication Date: 2009-08-01
    Description: The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here, we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences. Using two different operant tasks, we revealed that, in making choices, rats subjected to chronic stress became insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying these different behavioral strategies, with atrophy of medial prefrontal cortex and the associative striatum and hypertrophy of the sensorimotor striatum. These data suggest that the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dias-Ferreira, Eduardo -- Sousa, Joao C -- Melo, Irene -- Morgado, Pedro -- Mesquita, Ana R -- Cerqueira, Joao J -- Costa, Rui M -- Sousa, Nuno -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2009 Jul 31;325(5940):621-5. doi: 10.1126/science.1171203.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19644122" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atrophy ; Cell Count ; Choice Behavior ; Chronic Disease ; Corpus Striatum/*pathology ; *Decision Making ; Dendrites/pathology ; Frontal Lobe/*pathology ; Habits ; Hypertrophy ; Neural Pathways/pathology ; Neurons/pathology ; Prefrontal Cortex/pathology ; Rats ; Rats, Long-Evans ; Rats, Wistar ; Reinforcement (Psychology) ; Stress, Psychological/*pathology/*psychology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 113
    Publication Date: 2009-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Jim Yong -- New York, N.Y. -- Science. 2009 Apr 24;324(5926):457. doi: 10.1126/science.324_457.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19390019" target="_blank"〉PubMed〈/a〉
    Keywords: Asian Americans ; Global Health ; Humans ; Korea ; United States ; Universities/*organization & administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 114
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2009 May 22;324(5930):1000-1. doi: 10.1126/science.324_1000a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19460975" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/*legislation & jurisprudence ; *Genes, BRCA1 ; *Genes, BRCA2 ; Humans ; Jurisprudence ; Patents as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 115
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2009 Jun 12;324(5933):1374. doi: 10.1126/science.324_1374.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19520926" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/*legislation & jurisprudence ; Commerce/*legislation & jurisprudence ; Patents as Topic/*legislation & jurisprudence ; *Supreme Court Decisions ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 116
    Publication Date: 2009-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abbadessa, Giovanni -- Accolla, Roberto -- Aiuti, Fernando -- Albini, Adriana -- Aldovini, Anna -- Alfano, Massimo -- Antonelli, Guido -- Bartholomew, Courtenay -- Bentwich, Zvi -- Bertazzoni, Umberto -- Berzofsky, Jay A -- Biberfeld, Peter -- Boeri, Enzo -- Buonaguro, Luigi -- Buonaguro, Franco M -- Bukrinsky, Michael -- Burny, Arsene -- Caruso, Arnaldo -- Cassol, Sharon -- Chandra, Prakash -- Ceccherini-Nelli, Luca -- Chieco-Bianchi, Luigi -- Clerici, Mario -- Colombini-Hatch, Sandra -- de Giuli Morghen, Carlo -- de Maria, Andrea -- de Rossi, Anita -- Dierich, Manfred -- Della-Favera, Riccardo -- Dolei, Antonina -- Douek, Daniel -- Erfle, Volker -- Felber, Barbara -- Fiorentini, Simona -- Franchini, Genoveffa -- Gershoni, Jonathan M -- Gotch, Frances -- Green, Patrick -- Greene, Warner C -- Hall, William -- Haseltine, William -- Jacobson, Stephens -- Kallings, Lars O -- Kalyanaraman, Vaniambadi S -- Katinger, Hermann -- Khalili, Kamel -- Klein, George -- Klein, Eva -- Klotman, Mary -- Klotman, Paul -- Kotler, Moshe -- Kurth, Reinhard -- Lafeuillade, Alain -- La Placa, Michelangelo -- Lewis, Jonathan -- Lillo, Flavia -- Lisziewicz, Julianna -- Lomonico, Anita -- Lopalco, Lucia -- Lori, Franco -- Lusso, Paolo -- Macchi, Beatrice -- Malim, Michael -- Margolis, Leonid -- Markham, Phillip D -- McClure, Myra -- Miller, Nancy -- Mingari, Maria C -- Moretta, Lorenzo -- Noonan, Douglas -- O'Brien, Steve -- Okamoto, Takashi -- Pal, Ranajit -- Palese, Peter -- Panet, Amos -- Pantaleo, Giuseppe -- Pavlakis, George -- Pistello, Mauro -- Plotkin, Stanley -- Poli, Guido -- Pomerantz, Roger -- Radaelli, Antonia -- Robertguroff, Marjorie -- Roederer, Mario -- Sarngadharan, Mangalasseril G -- Schols, Dominique -- Secchiero, Paola -- Shearer, Gene -- Siccardi, Antonio -- Stevenson, Mario -- Svoboda, Jan -- Tartaglia, Jim -- Torelli, Giuseppe -- Tornesello, Maria Lina -- Tschachler, Erwin -- Vaccarezza, Mauro -- Vallbracht, Angelika -- van Lunzen, Jan -- Varnier, Oliviero -- Vicenzi, Elisa -- von Melchner, Harald -- Witz, Isaac -- Zagury, Daniel -- Zagury, Jean-Francois -- Zauli, Giorgio -- Zipeto, Donato -- New York, N.Y. -- Science. 2009 Jan 9;323(5911):206-7. doi: 10.1126/science.323.5911.206.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19131607" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/diagnosis/*history/virology ; *HIV-1/growth & development/isolation & purification ; History, 20th Century ; History, 21st Century ; Humans ; *Nobel Prize ; United States
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  • 117
    Publication Date: 2009-12-08
    Description: Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenic strains from the diabetic Goto-Kakizaki rat, we identified a 1.4-megabase genomic locus that was linked to impaired insulin granule docking at the plasma membrane and reduced beta cell exocytosis. In this locus, Adra2a, encoding the alpha2A-adrenergic receptor [alpha(2A)AR], was significantly overexpressed. Alpha(2A)AR mediates adrenergic suppression of insulin secretion. Pharmacological receptor antagonism, silencing of receptor expression, or blockade of downstream effectors rescued insulin secretion in congenic islets. Furthermore, we identified a single-nucleotide polymorphism in the human ADRA2A gene for which risk allele carriers exhibited overexpression of alpha(2A)AR, reduced insulin secretion, and increased type 2 diabetes risk. Human pancreatic islets from risk allele carriers exhibited reduced granule docking and secreted less insulin in response to glucose; both effects were counteracted by pharmacological alpha(2A)AR antagonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosengren, Anders H -- Jokubka, Ramunas -- Tojjar, Damon -- Granhall, Charlotte -- Hansson, Ola -- Li, Dai-Qing -- Nagaraj, Vini -- Reinbothe, Thomas M -- Tuncel, Jonatan -- Eliasson, Lena -- Groop, Leif -- Rorsman, Patrik -- Salehi, Albert -- Lyssenko, Valeriya -- Luthman, Holger -- Renstrom, Erik -- New York, N.Y. -- Science. 2010 Jan 8;327(5962):217-20. doi: 10.1126/science.1176827. Epub 2009 Nov 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lund University Diabetes Centre, Malmo, SE-20502 Malmo, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965390" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adrenergic alpha-2 Receptor Agonists ; Adrenergic alpha-2 Receptor Antagonists ; Adrenergic alpha-Agonists/pharmacology ; Adrenergic alpha-Antagonists/pharmacology ; Adult ; Aged ; Animals ; Animals, Congenic ; Blood Glucose/metabolism ; Cell Membrane/metabolism ; Cyclic AMP/metabolism ; Diabetes Mellitus, Type 2/*genetics/metabolism ; Exocytosis ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Insulin/blood/*secretion ; Insulin-Secreting Cells/*secretion ; Middle Aged ; Polymorphism, Single Nucleotide ; RNA Interference ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic, alpha-2/*genetics/*metabolism ; Risk Factors ; Secretory Vesicles/metabolism ; Up-Regulation ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 118
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pala, Christopher -- New York, N.Y. -- Science. 2009 Jan 9;323(5911):192-3. doi: 10.1126/science.323.5911.192.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19131597" target="_blank"〉PubMed〈/a〉
    Keywords: American Samoa ; Animals ; Conservation of Natural Resources/*legislation & jurisprudence ; *Ecosystem ; Fishes ; Micronesia ; Pacific Islands ; Pacific Ocean ; United States
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  • 119
    Publication Date: 2009-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):346-7. doi: 10.1126/science.326_346.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833925" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry/*history ; Crystallography, X-Ray ; Great Britain ; History, 20th Century ; History, 21st Century ; Israel ; *Nobel Prize ; *Ribosomes/physiology/ultrastructure ; United States
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  • 120
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2009 Jan 23;323(5913):452-3. doi: 10.1126/science.323.5913.452b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19164720" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, CD/*genetics ; Biotechnology/*legislation & jurisprudence ; *Genes ; Humans ; Patents as Topic/*legislation & jurisprudence ; Receptors, Immunologic/*genetics ; United States
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  • 121
    Publication Date: 2009-07-11
    Description: mu-Opioid receptor (MOR) agonists represent the gold standard for the treatment of severe pain but may paradoxically also enhance pain sensitivity, that is, lead to opioid-induced hyperalgesia (OIH). We show that abrupt withdrawal from MOR agonists induces long-term potentiation (LTP) at the first synapse in pain pathways. Induction of opioid withdrawal LTP requires postsynaptic activation of heterotrimeric guanine nucleotide-binding proteins and N-methyl-d-aspartate receptors and a rise of postsynaptic calcium concentrations. In contrast, the acute depression by opioids is induced presynaptically at these synapses. Withdrawal LTP can be prevented by tapered withdrawal and shares pharmacology and signal transduction pathways with OIH. These findings provide a previously unrecognized target to selectively combat pro-nociceptive effects of opioids without compromising opioid analgesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Drdla, Ruth -- Gassner, Matthias -- Gingl, Ewald -- Sandkuhler, Jurgen -- P 18129/Austrian Science Fund FWF/Austria -- New York, N.Y. -- Science. 2009 Jul 10;325(5937):207-10. doi: 10.1126/science.1171759.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19590003" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics, Opioid/administration & dosage/*adverse effects/pharmacology ; Animals ; Calcium/metabolism ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/administration & dosage/adverse ; effects/pharmacology ; Evoked Potentials ; GTP-Binding Proteins/metabolism ; Hyperalgesia/chemically induced ; *Long-Term Potentiation/drug effects ; Male ; Nerve Fibers, Unmyelinated/physiology ; Patch-Clamp Techniques ; Piperidines/administration & dosage/adverse effects/pharmacology ; Posterior Horn Cells/drug effects/physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, Opioid, mu/*agonists ; Signal Transduction ; Substance Withdrawal Syndrome/*physiopathology ; Synapses/drug effects/*physiology
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  • 122
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- Pennisi, Elizabeth -- New York, N.Y. -- Science. 2009 Oct 9;326(5950):212-3. doi: 10.1126/science.326_212.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19815741" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease ; History, 20th Century ; History, 21st Century ; Humans ; *Nobel Prize ; *Telomerase/chemistry/isolation & purification/metabolism ; *Telomere/physiology ; United States
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  • 123
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dowswell, Christopher -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):381. doi: 10.1126/science.1182211.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833952" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*history/methods ; Crops, Agricultural/*history ; Developing Countries ; History, 20th Century ; History, 21st Century ; Internationality ; Nobel Prize ; United States
    Print ISSN: 0036-8075
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  • 124
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):28-9. doi: 10.1126/science.323.5910.28.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119194" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Politics ; *Public Policy ; *Science ; United States
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  • 125
    Publication Date: 2009-01-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):22-3. doi: 10.1126/science.323.5910.22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119188" target="_blank"〉PubMed〈/a〉
    Keywords: History, 21st Century ; *Public Policy ; *Science ; *Technology ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 126
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doty, F David -- New York, N.Y. -- Science. 2009 Jun 12;324(5933):1389; author reply 1390-1. doi: 10.1126/science.324_1389b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Doty Energy, 700 Clemson Road, Columbia, SC 29229, USA. david@dotynmr.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19520939" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Energy-Generating Resources/*economics ; Fossil Fuels/economics ; United States ; Wood/*economics
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  • 127
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butera, Robert J -- New York, N.Y. -- Science. 2009 Sep 18;325(5947):1499. doi: 10.1126/science.325_1499a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0250, USA. rbutera@gatech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19762628" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Graduate/*economics ; *Fellowships and Scholarships ; Financing, Government ; *Research Support as Topic ; *Training Support ; United States ; United States Government Agencies/economics
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  • 128
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Dec 11;326(5959):1467. doi: 10.1126/science.326.5959.1467-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20007872" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Line ; *Embryo Research/economics ; *Embryonic Stem Cells ; Financing, Government ; Humans ; *National Institutes of Health (U.S.)/economics ; Research Support as Topic ; United States
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  • 129
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2009 Aug 7;325(5941):664. doi: 10.1126/science.325_664.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661393" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; *Patents as Topic ; *Phylogeny ; *Sequence Analysis, DNA ; United States
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  • 130
    Publication Date: 2009-05-16
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869292/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869292/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andrews, N -- Burris, J E -- Cech, T R -- Coller, B S -- Crowley, W F Jr -- Gallin, E K -- Kelner, K L -- Kirch, D G -- Leshner, A I -- Morris, C D -- Nguyen, F T -- Oates, J -- Sung, N S -- R01 HD015788/HD/NICHD NIH HHS/ -- U54 HD028138/HD/NICHD NIH HHS/ -- U54 HD028138-19/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2009 May 15;324(5929):855. doi: 10.1126/science.1172137.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19443750" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research/education ; *Career Choice ; *Clinical Medicine/education ; Humans ; Interdisciplinary Communication ; Internet ; National Institutes of Health (U.S.) ; *Societies, Scientific ; United States
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  • 131
    Publication Date: 2009-12-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krane, D E -- Bahn, V -- Balding, D -- Barlow, B -- Cash, H -- Desportes, B L -- D'Eustachio, P -- Devlin, K -- Doom, T E -- Dror, I -- Ford, S -- Funk, C -- Gilder, J -- Hampikian, G -- Inman, K -- Jamieson, A -- Kent, P E -- Koppl, R -- Kornfield, I -- Krimsky, S -- Mnookin, J -- Mueller, L -- Murphy, E -- Paoletti, D R -- Petrov, D A -- Raymer, M -- Risinger, D M -- Roth, A -- Rudin, N -- Shields, W -- Siegel, J A -- Slatkin, M -- Song, Y S -- Speed, T -- Spiegelman, C -- Sullivan, P -- Swienton, A R -- Tarpey, T -- Thompson, W C -- Ungvarsky, E -- Zabell, S -- New York, N.Y. -- Science. 2009 Dec 18;326(5960):1631-2. doi: 10.1126/science.326.5960.1631.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20019271" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; *Databases, Nucleic Acid ; Humans ; Privacy ; United States ; United States Government Agencies
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 132
    Publication Date: 2009-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sim, Ida -- Chute, Christopher G -- Lehmann, Harold -- Nagarajan, Rakesh -- Nahm, Meredith -- Scheuermann, Richard H -- R01 RR026040/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2009 Feb 6;323(5915):713. doi: 10.1126/science.323.5915.713a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19197039" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; *Biomedical Research ; *Clinical Trials as Topic ; *Databases, Factual ; Humans ; *Information Dissemination ; National Institutes of Health (U.S.) ; Periodicals as Topic ; Publishing ; Research Design ; United States
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  • 133
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, Robert -- New York, N.Y. -- Science. 2009 Jun 12;324(5933):1386. doi: 10.1126/science.324_1386b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19520936" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines/*education ; Humans ; Science/*education ; *Students ; United States ; *Universities ; *Vulnerable Populations
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  • 134
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2009 May 15;324(5929):871. doi: 10.1126/science.324_871.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19443759" target="_blank"〉PubMed〈/a〉
    Keywords: Centers for Disease Control and Prevention (U.S.) ; *Disease Outbreaks ; Humans ; Influenza A Virus, H1N1 Subtype/*classification ; Influenza, Human/*epidemiology/virology ; *Terminology as Topic ; United States ; World Health Organization
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  • 135
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Dec 4;326(5958):1332. doi: 10.1126/science.326.5958.1332.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965727" target="_blank"〉PubMed〈/a〉
    Keywords: *Faculty ; *Internet ; Private Sector ; Science/*education ; United States
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  • 136
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, Robert -- New York, N.Y. -- Science. 2009 May 22;324(5930):1003. doi: 10.1126/science.324_1003.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19460977" target="_blank"〉PubMed〈/a〉
    Keywords: Centers for Disease Control and Prevention (U.S.)/*organization & administration ; History, 20th Century ; History, 21st Century ; *Public Health ; Public Health Administration ; United States
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  • 137
    Publication Date: 2009-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Higgins, Matthew J -- Graham, Stuart J H -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):370-1. doi: 10.1126/science.1176116.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Management, Georgia Institute of Technology, Atlanta, GA 30308, USA. matt.higgins@mgt.gatech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833944" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Discovery/economics ; Drug Industry/economics/*legislation & jurisprudence ; Drugs, Generic ; *Legislation, Drug ; Patents as Topic/*legislation & jurisprudence ; *Pharmaceutical Preparations ; United States
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  • 138
    Publication Date: 2009-09-12
    Description: Action potentials in nonmyelinated axons are considered to contribute substantially to activity-dependent brain metabolism. Here we show that fast Na+ current decay and delayed K+ current onset during action potentials in nonmyelinated mossy fibers of the rat hippocampus minimize the overlap of their respective ion fluxes. This results in total Na+ influx and associated energy demand per action potential of only 1.3 times the theoretical minimum, in contrast to the factor of 4 used in previous energy budget calculations for neural activity. Analysis of ionic conductance parameters revealed that the properties of Na+ and K+ channels are matched to make axonal action potentials energy-efficient, minimizing their contribution to activity-dependent metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alle, Henrik -- Roth, Arnd -- Geiger, Jorg R P -- New York, N.Y. -- Science. 2009 Sep 11;325(5946):1405-8. doi: 10.1126/science.1174331.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Independent Hertie Research Group, Max-Planck-Institute for Brain Research, 60528 Frankfurt, Germany. henrik.alle@charite.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19745156" target="_blank"〉PubMed〈/a〉
    Keywords: *Action Potentials ; Animals ; Axons/physiology ; *Energy Metabolism ; Mossy Fibers, Hippocampal/*physiology ; Patch-Clamp Techniques ; Potassium/metabolism ; Potassium Channels/metabolism ; Presynaptic Terminals/physiology ; Rats ; Rats, Wistar ; Sodium/metabolism ; Sodium Channels/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Synaptic Transmission
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  • 139
    Publication Date: 2009-12-17
    Description: Metabotropic glutamate receptor 5 (mGluR5) is highly expressed in the mammalian central nervous system (CNS). It is involved in multiple physiological functions and is a target for treatment of various CNS disorders, including schizophrenia. We report that Norbin, a neuron-specific protein, physically interacts with mGluR5 in vivo, increases the cell surface localization of the receptor, and positively regulates mGluR5 signaling. Genetic deletion of Norbin attenuates mGluR5-dependent stable changes in synaptic function measured as long-term depression or long-term potentiation of synaptic transmission in the hippocampus. As with mGluR5 knockout mice or mice treated with mGluR5-selective antagonists, Norbin knockout mice showed a behavioral phenotype associated with a rodent model of schizophrenia, as indexed by alterations both in sensorimotor gating and psychotomimetic-induced locomotor activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796550/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796550/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Hong -- Westin, Linda -- Nong, Yi -- Birnbaum, Shari -- Bendor, Jacob -- Brismar, Hjalmar -- Nestler, Eric -- Aperia, Anita -- Flajolet, Marc -- Greengard, Paul -- DA 10044/DA/NIDA NIH HHS/ -- MH074866/MH/NIMH NIH HHS/ -- MH66172/MH/NIMH NIH HHS/ -- P01 DA010044/DA/NIDA NIH HHS/ -- P01 DA010044-020002/DA/NIDA NIH HHS/ -- P01 DA010044-030002/DA/NIDA NIH HHS/ -- P01 DA010044-04/DA/NIDA NIH HHS/ -- P01 DA010044-040002/DA/NIDA NIH HHS/ -- P01 DA010044-05/DA/NIDA NIH HHS/ -- P01 DA010044-050002/DA/NIDA NIH HHS/ -- P01 DA010044-06/DA/NIDA NIH HHS/ -- P01 DA010044-060002/DA/NIDA NIH HHS/ -- P01 DA010044-07/DA/NIDA NIH HHS/ -- P01 DA010044-070002/DA/NIDA NIH HHS/ -- P01 DA010044-08/DA/NIDA NIH HHS/ -- P01 DA010044-080002/DA/NIDA NIH HHS/ -- P01 DA010044-09/DA/NIDA NIH HHS/ -- P01 DA010044-090002/DA/NIDA NIH HHS/ -- P01 DA010044-10/DA/NIDA NIH HHS/ -- P01 DA010044-100002/DA/NIDA NIH HHS/ -- P01 DA010044-11/DA/NIDA NIH HHS/ -- P01 DA010044-110005/DA/NIDA NIH HHS/ -- P01 DA010044-12/DA/NIDA NIH HHS/ -- P01 DA010044-120005/DA/NIDA NIH HHS/ -- P01 DA010044-129002/DA/NIDA NIH HHS/ -- P01 DA010044-13/DA/NIDA NIH HHS/ -- P01 DA010044-130005/DA/NIDA NIH HHS/ -- P01 DA010044-139002/DA/NIDA NIH HHS/ -- P01 DA010044-14/DA/NIDA NIH HHS/ -- P01 DA010044-140005/DA/NIDA NIH HHS/ -- P01 DA010044-149002/DA/NIDA NIH HHS/ -- P01 DA010044-14S1/DA/NIDA NIH HHS/ -- P01 DA010044-14S10005/DA/NIDA NIH HHS/ -- P01 DA010044-14S19002/DA/NIDA NIH HHS/ -- P50 MH074866/MH/NIMH NIH HHS/ -- P50 MH074866-010001/MH/NIMH NIH HHS/ -- P50 MH074866-020001/MH/NIMH NIH HHS/ -- P50 MH074866-030001/MH/NIMH NIH HHS/ -- P50 MH074866-039001/MH/NIMH NIH HHS/ -- P50 MH074866-040001/MH/NIMH NIH HHS/ -- P50 MH074866-050001/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2009 Dec 11;326(5959):1554-7. doi: 10.1126/science.1178496.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20007903" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Calcium/metabolism ; Calcium Signaling ; Cell Line ; Cell Membrane/metabolism ; Humans ; Mice ; Mice, Knockout ; Motor Activity ; Nerve Tissue Proteins/genetics/*metabolism ; Neuronal Plasticity ; Protein Binding ; Rats ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate/genetics/*metabolism ; Reflex, Startle ; Schizophrenia/physiopathology ; *Signal Transduction ; Synaptic Transmission ; Transfection
    Print ISSN: 0036-8075
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  • 140
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-11-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Oct 30;326(5953):654. doi: 10.1126/science.326_654b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19900906" target="_blank"〉PubMed〈/a〉
    Keywords: Engineering/education ; Mathematics/education ; Public Policy ; Science/*education ; Technology/education ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 141
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1660-1. doi: 10.1126/science.323.5922.1660b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325092" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics/organization & administration ; Biotechnology/*economics ; Financing, Government ; Humans ; *Research Support as Topic ; State Government ; *Stem Cells ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 142
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charles, Dan -- New York, N.Y. -- Science. 2009 May 1;324(5927):587. doi: 10.1126/science.324_587.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19407177" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; California ; Conservation of Natural Resources ; Energy-Generating Resources/*standards ; *Ethanol ; Gasoline/standards ; *Government Regulation ; Greenhouse Effect ; State Government ; United States ; United States Environmental Protection Agency ; Vehicle Emissions/legislation & jurisprudence ; *Zea mays
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 143
    Publication Date: 2009-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1660-1. doi: 10.1126/science.323.5922.1660a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325091" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics/organization & administration ; *Biomedical Research/economics ; California ; Cell Line ; Clinical Trials as Topic ; Embryo Research/economics/legislation & jurisprudence ; *Embryonic Stem Cells ; Financing, Government ; Humans ; National Institutes of Health (U.S.) ; Research Support as Topic ; State Government ; *Stem Cells ; United States
    Print ISSN: 0036-8075
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  • 144
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Nov 6;326(5954):783. doi: 10.1126/science.326_783a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19892954" target="_blank"〉PubMed〈/a〉
    Keywords: American Recovery and Reinvestment Act/*statistics & numerical data ; Employment/*statistics & numerical data ; Humans ; Pilot Projects ; Research/*economics ; United States ; Universities/*economics
    Print ISSN: 0036-8075
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  • 145
    Publication Date: 2009-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Mar 20;323(5921):1552-3. doi: 10.1126/science.323.5921.1552a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19299595" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cloning, Organism/legislation & jurisprudence ; Embryo Research/ethics/*legislation & jurisprudence ; *Embryonic Stem Cells ; Financing, Government/legislation & jurisprudence ; Government Regulation ; Guidelines as Topic ; Humans ; National Institutes of Health (U.S.) ; Politics ; Research Support as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 146
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2009 Jan 23;323(5913):447. doi: 10.1126/science.323.5913.447.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19164712" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; *Coniferophyta/growth & development ; *Ecosystem ; Greenhouse Effect ; *Trees/growth & development ; United States
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  • 147
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1155. doi: 10.1126/science.323.5918.1155.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19251597" target="_blank"〉PubMed〈/a〉
    Keywords: Coroners and Medical Examiners ; Dermatoglyphics ; *Forensic Medicine/methods/organization & administration/standards ; *Forensic Sciences/methods/organization & administration/standards ; Humans ; United States
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  • 148
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wetmore, Jameson M -- Bennett, Ira -- Hooke, William H -- Miller, Tim -- New York, N.Y. -- Science. 2009 Apr 17;324(5925):334. doi: 10.1126/science.324.5925.334a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19372410" target="_blank"〉PubMed〈/a〉
    Keywords: *Communication ; *Public Policy ; Public Relations ; *Science ; United States
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  • 149
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):801. doi: 10.1126/science.325_801a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19679779" target="_blank"〉PubMed〈/a〉
    Keywords: Public Policy ; *Research ; Research Support as Topic ; *Science ; *Technology ; United States
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  • 150
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2009 Nov 6;326(5954):794-5. doi: 10.1126/science.326_794.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19892959" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Costs and Cost Analysis ; *Genome ; Genome, Human ; Humans ; International Cooperation ; National Human Genome Research Institute (U.S.) ; *Sequence Analysis, DNA/economics/methods ; United States ; Vertebrates/*genetics
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  • 151
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Jul 31;325(5940):528-30. doi: 10.1126/science.325_528.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19644085" target="_blank"〉PubMed〈/a〉
    Keywords: Education, Graduate/*economics ; *Fellowships and Scholarships ; *Financing, Government ; *Research Support as Topic ; Science/education ; *Training Support ; United States ; Universities/*economics
    Print ISSN: 0036-8075
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  • 152
    Publication Date: 2009-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charles, Dan -- Kaiser, Jocelyn -- Kintisch, Eli -- Stokstad, Erik -- New York, N.Y. -- Science. 2009 May 15;324(5929):864-6. doi: 10.1126/science.324_864b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19443751" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; *Budgets ; Greenhouse Effect ; National Institutes of Health (U.S.)/economics/organization & administration ; Public Policy ; *Science ; Technology ; United States ; United States Environmental Protection Agency/legislation & ; jurisprudence/organization & administration
    Print ISSN: 0036-8075
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  • 153
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoff, Kevin G -- New York, N.Y. -- Science. 2009 May 15;324(5929):880. doi: 10.1126/science.324_880b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. khoff@caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19443765" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Employment ; Financing, Government/*legislation & jurisprudence ; National Institutes of Health (U.S.)/*economics/legislation & jurisprudence ; Research Personnel/*economics ; *Research Support as Topic/legislation & jurisprudence ; United States
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  • 154
    Publication Date: 2009-08-08
    Description: Diminished synaptic inhibition in the spinal dorsal horn is a major contributor to chronic pain. Pathways that reduce synaptic inhibition in inflammatory and neuropathic pain states have been identified, but central hyperalgesia and diminished dorsal horn synaptic inhibition also occur in the absence of inflammation or neuropathy, solely triggered by intense nociceptive (C-fiber) input to the spinal dorsal horn. We found that endocannabinoids, produced upon strong nociceptive stimulation, activated type 1 cannabinoid (CB1) receptors on inhibitory dorsal horn neurons to reduce the synaptic release of gamma-aminobutyric acid and glycine and thus rendered nociceptive neurons excitable by nonpainful stimuli. Our results suggest that spinal endocannabinoids and CB1 receptors on inhibitory dorsal horn interneurons act as mediators of heterosynaptic pain sensitization and play an unexpected role in dorsal horn pain-controlling circuits.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835775/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835775/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pernia-Andrade, Alejandro J -- Kato, Ako -- Witschi, Robert -- Nyilas, Rita -- Katona, Istvan -- Freund, Tamas F -- Watanabe, Masahiko -- Filitz, Jorg -- Koppert, Wolfgang -- Schuttler, Jurgen -- Ji, Guangchen -- Neugebauer, Volker -- Marsicano, Giovanni -- Lutz, Beat -- Vanegas, Horacio -- Zeilhofer, Hanns Ulrich -- NS11255/NS/NINDS NIH HHS/ -- NS38261/NS/NINDS NIH HHS/ -- P01 NS011255/NS/NINDS NIH HHS/ -- P01 NS011255-32A20042/NS/NINDS NIH HHS/ -- P01 NS011255-330042/NS/NINDS NIH HHS/ -- R01 NS038261/NS/NINDS NIH HHS/ -- R01 NS038261-08/NS/NINDS NIH HHS/ -- R01 NS038261-09/NS/NINDS NIH HHS/ -- R01 NS038261-10/NS/NINDS NIH HHS/ -- R01 NS038261-10S1/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2009 Aug 7;325(5941):760-4. doi: 10.1126/science.1171870.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661434" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Cannabinoid Receptor Modulators/*physiology ; Electric Stimulation ; *Endocannabinoids ; Excitatory Postsynaptic Potentials ; Female ; Humans ; Hyperalgesia/*physiopathology ; Inhibitory Postsynaptic Potentials ; Interneurons/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Nerve Fibers, Unmyelinated/*physiology ; Neural Inhibition ; Pain/*physiopathology ; Piperidines/administration & dosage/pharmacology ; Posterior Horn Cells/*physiology ; Pyrazoles/administration & dosage/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/antagonists & inhibitors/*metabolism ; Spinal Cord/cytology/physiology ; *Synaptic Transmission ; Young Adult
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  • 155
    Publication Date: 2009-03-17
    Description: Patolsky et al. (Reports, 25 August 2006, p. 1100) used silicon nanowires to record action potentials in rat neuronal axons and found increases in conductance of about 85 nanosiemens. We point out that the data correspond to voltage changes of about -85 millivolts on the nanowire and that conceivable mechanisms of axon-nanowire interaction lead to signals that are opposite in sign or smaller by orders of magnitude.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fromherz, Peter -- Voelker, Moritz -- New York, N.Y. -- Science. 2009 Mar 13;323(5920):1429; author reply 1429. doi: 10.1126/science.1155416.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Membrane and Neurophysics, Max Planck Institute for Biochemistry, D82152 Martinsried/Munich, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19286538" target="_blank"〉PubMed〈/a〉
    Keywords: *Action Potentials ; Animals ; Axons/*physiology ; Electric Conductivity ; Electric Stimulation ; Ion Channel Gating ; *Nanowires ; Neural Inhibition ; Neurons/*physiology ; Rats ; Semiconductors ; Silicon ; Sodium/metabolism ; Static Electricity ; Transistors, Electronic
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  • 156
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Jul 3;325(5936):18. doi: 10.1126/science.325_18.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19574355" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/economics/legislation & jurisprudence ; Budgets ; Commerce/*economics/organization & administration ; Financing, Government/*legislation & jurisprudence ; National Institutes of Health (U.S.)/*economics/organization & administration ; Politics ; Research Support as Topic/*legislation & jurisprudence ; Societies, Scientific ; United States
    Print ISSN: 0036-8075
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  • 157
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Jun 19;324(5934):1498. doi: 10.1126/science.324_1498.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19541960" target="_blank"〉PubMed〈/a〉
    Keywords: Engineering/*education ; Faculty ; *Mathematics ; Science/*education ; Technology/*education ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 158
    Publication Date: 2009-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ramanathan, Veerabhadran -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):361. doi: 10.1126/science.326_361.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833937" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture/history ; *Crops, Agricultural/genetics/history ; History, 20th Century ; History, 21st Century ; Humans ; India/epidemiology ; Malnutrition/epidemiology ; *Triticum/genetics ; United States
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  • 159
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeyaseelan, Samithamby -- New York, N.Y. -- Science. 2009 Jan 16;323(5912):337. doi: 10.1126/science.323.5912.337a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19150826" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Career Mobility ; Financing, Government ; National Institutes of Health (U.S.)/*economics/statistics & numerical data ; *Research Personnel ; Research Support as Topic/*statistics & numerical data ; United States
    Print ISSN: 0036-8075
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  • 160
    Publication Date: 2009-11-11
    Description: Presynaptic axonal differentiation is essential for synapse formation and the establishment of neuronal circuits. However, the mechanisms that coordinate presynaptic development in the brain are largely unknown. We found that the major mitotic E3 ubiquitin ligase Cdc20-anaphase promoting complex (Cdc20-APC) regulates presynaptic differentiation in primary postmitotic mammalian neurons and in the rat cerebellar cortex. Cdc20-APC triggered the degradation of the transcription factor NeuroD2 and thereby promoted presynaptic differentiation. The NeuroD2 target gene encoding Complexin II, which acts locally at presynaptic sites, mediated the ability of NeuroD2 to suppress presynaptic differentiation. Thus, our findings define a Cdc20-APC ubiquitin signaling pathway that governs presynaptic development, which holds important implications for neuronal connectivity and plasticity in the brain.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846784/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846784/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Yue -- Kim, Albert H -- Yamada, Tomoko -- Wu, Bei -- Bilimoria, Parizad M -- Ikeuchi, Yoshiho -- de la Iglesia, Nuria -- Shen, Jie -- Bonni, Azad -- F32 CA124028/CA/NCI NIH HHS/ -- NS041021/NS/NINDS NIH HHS/ -- NS051255/NS/NINDS NIH HHS/ -- R01 NS041021/NS/NINDS NIH HHS/ -- R01 NS041021-06/NS/NINDS NIH HHS/ -- R01 NS041021-07/NS/NINDS NIH HHS/ -- R01 NS041021-08/NS/NINDS NIH HHS/ -- R01 NS051255/NS/NINDS NIH HHS/ -- R01 NS051255-02/NS/NINDS NIH HHS/ -- R01 NS051255-03/NS/NINDS NIH HHS/ -- R01 NS051255-04/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2009 Oct 23;326(5952):575-8. doi: 10.1126/science.1177087.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19900895" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Vesicular Transport/genetics/metabolism ; Anaphase-Promoting Complex-Cyclosome ; Animals ; Axons/metabolism/*physiology/ultrastructure ; Basic Helix-Loop-Helix Transcription Factors/genetics/metabolism ; Cdc20 Proteins ; Cell Cycle Proteins/genetics/*metabolism ; Cerebellar Cortex/cytology/metabolism/ultrastructure ; Gene Knockdown Techniques ; Mutant Proteins/metabolism ; Nerve Tissue Proteins/genetics/metabolism ; Neuropeptides/genetics/metabolism ; Presynaptic Terminals/*metabolism ; Rats ; *Signal Transduction ; Synapses/*metabolism ; Synapsins/metabolism ; Synaptic Vesicles/genetics/metabolism ; Ubiquitin/*metabolism ; Ubiquitin-Protein Ligase Complexes/genetics/*metabolism ; Ubiquitin-Protein Ligases/*metabolism
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  • 161
    Publication Date: 2009-03-21
    Description: Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine-lesioned rats. The functional recovery was paralleled by a disruption of aberrant low-frequency synchronous corticostriatal oscillations, leading to the emergence of neuronal activity patterns that resemble the state normally preceding spontaneous initiation of locomotion. We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson's disease in the future.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669752/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669752/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuentes, Romulo -- Petersson, Per -- Siesser, William B -- Caron, Marc G -- Nicolelis, Miguel A L -- R21 NS049534/NS/NINDS NIH HHS/ -- R21 NS049534-01A2/NS/NINDS NIH HHS/ -- R21 NS049534-02/NS/NINDS NIH HHS/ -- R33 NS049534/NS/NINDS NIH HHS/ -- R33 NS049534-03/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2009 Mar 20;323(5921):1578-82. doi: 10.1126/science.1164901.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. fuentes@neuro.duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19299613" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Combined Modality Therapy ; Corpus Striatum/physiopathology ; Dopamine/metabolism ; *Electric Stimulation Therapy ; Electrodes, Implanted ; Electrophysiological Phenomena ; Humans ; Levodopa/administration & dosage/therapeutic use ; *Locomotion ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Cortex/physiopathology ; Neurons/physiology ; Oxidopamine/pharmacology ; Parkinson Disease/physiopathology/*therapy ; Parkinsonian Disorders/physiopathology/*therapy ; Rats ; Spinal Cord/*physiology ; alpha-Methyltyrosine/pharmacology
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  • 162
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 May 29;324(5931):1128-9. doi: 10.1126/science.324_1128b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478152" target="_blank"〉PubMed〈/a〉
    Keywords: *Biology ; *Biotechnology ; Financing, Government ; *Genetic Engineering ; Government Agencies/economics ; Great Britain ; *Peer Review, Research ; *Research Support as Topic ; United States ; United States Government Agencies/economics
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  • 163
    Publication Date: 2009-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 May 15;324(5929):864-6. doi: 10.1126/science.324_864a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19443752" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; *Budgets ; Financing, Government/legislation & jurisprudence ; Research/*economics ; Science/*economics ; United States ; United States Government Agencies/*economics
    Print ISSN: 0036-8075
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  • 164
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickering, Thomas R -- New York, N.Y. -- Science. 2009 Jul 3;325(5936):11. doi: 10.1126/science.1175089.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19574352" target="_blank"〉PubMed〈/a〉
    Keywords: *Food Supply ; *Global Health ; Humans ; International Cooperation ; *Poverty ; *United Nations ; United States ; *Water Supply
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  • 165
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pielke, Roger A -- New York, N.Y. -- Science. 2009 Feb 20;323(5917):1010. doi: 10.1126/science.323.5917.1010a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19229020" target="_blank"〉PubMed〈/a〉
    Keywords: *Public Policy ; *Science ; United States
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  • 166
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-06-27
    Description: Cell self-renewal and the capacity to differentiate into multiple cell types (pluripotency) are biological attributes casting stem cells as attractive candidates for development of therapies targeting indications that involve functional restoration of damaged tissues. In the United States, clinical trials designed to demonstrate the safety and effectiveness of stem cell-based products are regulated by the U.S. Food and Drug Administration (FDA). To ensure that subjects enrolled in a clinical study involving stem cell-based products are not exposed to significant and unreasonable risk, the FDA reviews medical and scientific information that encompasses delineation of product-specific characteristics and preclinical testing to determine whether there is sufficient safety assurance to permit initiation of human clinical studies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fink, Donald W Jr -- New York, N.Y. -- Science. 2009 Jun 26;324(5935):1662-3. doi: 10.1126/science.1173712.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Mail Code HFM-720, Rockville, MD 20852-1448, USA. donald.fink@fda.hhs.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19556496" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Transformation, Neoplastic ; Clinical Trials as Topic/*standards ; Disease Models, Animal ; *Evaluation Studies as Topic ; *Government Regulation ; Humans ; Risk Assessment ; *Stem Cell Transplantation/adverse effects ; *Stem Cells ; United States ; *United States Food and Drug Administration
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  • 167
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-09-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pizzorusso, Tommaso -- New York, N.Y. -- Science. 2009 Sep 4;325(5945):1214-5. doi: 10.1126/science.1179697.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Istituto Neuroscienze CNR, via Moruzzi, 1 56100 Pisa, Italy. tommaso.pizzorusso@in.cnr.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19729646" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/cytology/growth & development/*physiology ; Animals ; Chondroitin ABC Lyase/metabolism ; Chondroitin Sulfate Proteoglycans/metabolism/*physiology ; Conditioning, Classical ; *Extinction, Psychological ; Extracellular Matrix/physiology ; *Fear ; Memory/*physiology ; Mice ; Neuronal Plasticity ; Rats ; Visual Cortex/growth & development/physiology
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  • 168
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Mar 6;323(5919):1274-5. doi: 10.1126/science.323.5919.1274.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19264988" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States ; United States Government Agencies/*economics
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  • 169
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clair, Timothy -- New York, N.Y. -- Science. 2009 Mar 6;323(5919):1288. doi: 10.1126/science.323.5919.1288a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19265000" target="_blank"〉PubMed〈/a〉
    Keywords: *Periodicals as Topic ; *Politics ; *Science ; United States
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  • 170
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2009 Jan 9;323(5911):195. doi: 10.1126/science.323.5911.195.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19131600" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*physiology ; Brain Mapping ; Humans ; *Jurisprudence ; *Magnetic Resonance Imaging ; *Pain/diagnosis/physiopathology ; *Pain Measurement ; United States
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  • 171
    Publication Date: 2009-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Sandra Soo-Jin -- Bolnick, Deborah A -- Duster, Troy -- Ossorio, Pilar -- Tallbear, Kimberly -- K01 HL72465/HL/NHLBI NIH HHS/ -- P50 HG003389/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2009 Jul 3;325(5936):38-9. doi: 10.1126/science.1173038.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford Center for Biomedical Ethics, Stanford University Medical School, Palo Alto, CA 94304, USA. sandra.lee@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19574373" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethical Issues ; Databases, Genetic ; *Genetic Research/ethics ; Genetic Testing/*standards ; *Genetic Variation ; Genetics, Medical ; Genetics, Population/*standards ; Guidelines as Topic ; Humans ; *Pedigree ; Population Groups/*genetics ; Public Policy ; Societies, Scientific ; United States ; United States Government Agencies
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  • 172
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lane, Neal -- New York, N.Y. -- Science. 2009 Apr 10;324(5924):147. doi: 10.1126/science.1174364.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19359547" target="_blank"〉PubMed〈/a〉
    Keywords: *Public Policy ; *Science ; *Societies, Scientific ; United States ; United States Government Agencies
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  • 173
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Jan 30;323(5914):571. doi: 10.1126/science.323.5914.571.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19179500" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government/legislation & jurisprudence ; Politics ; Research Support as Topic/*legislation & jurisprudence ; United States ; United States Government Agencies/economics/legislation & jurisprudence
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  • 174
    Publication Date: 2009-01-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Jan 16;323(5912):318-9. doi: 10.1126/science.323.5912.318.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19150814" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/economics ; *Economics ; Employment ; *Financing, Government ; Lobbying ; Research/*economics ; *Research Support as Topic ; Societies, Scientific ; United States ; Universities
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  • 175
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steitz, Thomas A -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1181. doi: 10.1126/science.1171157.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. thomas.steitz@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19251620" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemistry/*history ; Biophysics/*history ; History, 20th Century ; History, 21st Century ; Protein Conformation ; Proteins/*chemistry/metabolism ; Ribonuclease, Pancreatic/chemistry/metabolism ; United States
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  • 176
    Publication Date: 2009-08-08
    Description: Tuft dendrites are the main target for feedback inputs innervating neocortical layer 5 pyramidal neurons, but their properties remain obscure. We report the existence of N-methyl-D-aspartate (NMDA) spikes in the fine distal tuft dendrites that otherwise did not support the initiation of calcium spikes. Both direct measurements and computer simulations showed that NMDA spikes are the dominant mechanism by which distal synaptic input leads to firing of the neuron and provide the substrate for complex parallel processing of top-down input arriving at the tuft. These data lead to a new unifying view of integration in pyramidal neurons in which all fine dendrites, basal and tuft, integrate inputs locally through the recruitment of NMDA receptor channels relative to the fixed apical calcium and axosomatic sodium integration points.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larkum, Matthew E -- Nevian, Thomas -- Sandler, Maya -- Polsky, Alon -- Schiller, Jackie -- New York, N.Y. -- Science. 2009 Aug 7;325(5941):756-60. doi: 10.1126/science.1171958.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland. matthew.larkum@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661433" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Axons/physiology ; Calcium Signaling ; Computer Simulation ; Dendrites/*physiology ; Excitatory Postsynaptic Potentials ; In Vitro Techniques ; Models, Neurological ; N-Methylaspartate/metabolism ; Neocortex/cytology/*physiology ; Patch-Clamp Techniques ; Pyramidal Cells/*physiology ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/metabolism ; Sodium/metabolism ; Synapses/*physiology ; Synaptic Potentials
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berger, Kavita M -- Leshner, Alan I -- New York, N.Y. -- Science. 2009 May 29;324(5931):1117. doi: 10.1126/science.1176543.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478147" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Containment of Biohazards ; *Government Regulation ; *International Cooperation ; Public Policy ; Security Measures/*legislation & jurisprudence ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gast, Alice P -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1646. doi: 10.1126/science.1173327.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325081" target="_blank"〉PubMed〈/a〉
    Keywords: *Financing, Government ; *Research ; *Research Support as Topic ; *Science ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stevenson, Robert W -- Murphy, Joseph F -- Clare, Thomas J -- New York, N.Y. -- Science. 2009 May 22;324(5930):1014. doi: 10.1126/science.324_1014a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Caesar, Rivise, Bernstein, Cohen, and Pokotilow, Ltd., 1635 Market Street, 11th Floor, Philadelphia, PA 19103, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19460985" target="_blank"〉PubMed〈/a〉
    Keywords: Europe ; Patents as Topic/*legislation & jurisprudence ; *Robotics ; United States
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  • 180
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):32-5. doi: 10.1126/science.323.5910.32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119196" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antarctic Regions ; Astronomy ; Australia ; *Autopsy ; Cause of Death ; Coroners and Medical Examiners ; Forensic Pathology ; Humans ; Male ; Methanol/*poisoning ; New Zealand ; Poisoning/diagnosis ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
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  • 181
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zerhouni, Elias A -- New York, N.Y. -- Science. 2009 Feb 20;323(5917):983. doi: 10.1126/science.1172425.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19229001" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; *Budgets ; Financial Management ; Financing, Government ; Gift Giving ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leshner, Alan I -- New York, N.Y. -- Science. 2009 Apr 17;324(5925):313. doi: 10.1126/science.1174215.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19372394" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government/*legislation & jurisprudence ; *Information Dissemination ; Peer Review, Research ; *Research/economics/standards ; Research Support as Topic ; *Science/economics/standards ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
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  • 183
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-01-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):23. doi: 10.1126/science.323.5910.23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119189" target="_blank"〉PubMed〈/a〉
    Keywords: Institute of Medicine (U.S.)/*organization & administration ; *International Cooperation ; Iran ; *Science ; United States
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  • 184
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-12-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2009 Dec 18;326(5960):1618. doi: 10.1126/science.326.5960.1618.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20019268" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Conservation of Natural Resources ; *Ecosystem ; Oceans and Seas ; *Public Policy ; *Seawater ; United States ; United States Government Agencies/organization & administration
    Print ISSN: 0036-8075
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  • 185
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2009 Oct 9;326(5950):216. doi: 10.1126/science.326_216.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19815746" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; Financing, Government ; *Research/economics ; Research Support as Topic ; United States ; *United States Department of Agriculture/economics/legislation & ; jurisprudence/organization & administration
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  • 186
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Guanyang -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1672; author reply 1672. doi: 10.1126/science.323.5922.1672.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325099" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biodiversity ; *Biological Specimen Banks ; Databases, Factual ; *Databases, Nucleic Acid ; National Library of Medicine (U.S.) ; *Natural History ; United States
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  • 187
    Publication Date: 2009-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2009 Jul 10;325(5937):135. doi: 10.1126/science.325_135a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19589974" target="_blank"〉PubMed〈/a〉
    Keywords: *Autistic Disorder/etiology ; Humans ; Organizations/economics/*organization & administration ; *Research Support as Topic ; United States ; Vaccines/*adverse effects
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  • 188
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Subang, M C -- Richardson, P M -- New York, N.Y. -- Science. 2009 Oct 9;326(5950):238-9. doi: 10.1126/science.1181038.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bone and Joint Research, Barts and the London School of Medicine, Charterhouse Square, London EC1M 6BQ, UK. m.c.subang@qmul.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19815761" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology/ultrastructure ; Cell Nucleus/*metabolism ; Cytoskeleton/metabolism ; Growth Cones/*physiology/ultrastructure ; Hippocampus/cytology/embryology ; Intercellular Signaling Peptides and Proteins/metabolism ; Kruppel-Like Transcription Factors/genetics/*metabolism ; Mice ; Nerve Regeneration ; Nerve Tissue Proteins/metabolism ; Rats ; Retinal Ganglion Cells/cytology ; Transcription Factors/metabolism ; Transcription, Genetic
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  • 189
    Publication Date: 2009-02-14
    Description: Vesicular secretion of neurotransmitter is essential for neuronal communication. Kiss-and-run is a mode of membrane fusion and retrieval without the full collapse of the vesicle into the plasma membrane and de novo regeneration. The importance of kiss-and-run during efficient neurotransmission has remained in doubt. We developed an approach for loading individual synaptic vesicles with single quantum dots. Their size and pH-dependent photoluminescence change allowed us to distinguish kiss-and-run from full-collapse fusion and to track single vesicles through multiple rounds of kiss-and-run and reuse, without perturbing vesicle cycling. Kiss-and-run dominated at the beginning of stimulus trains, reflecting the preference of vesicles with high release probability. Its incidence was increased by rapid firing, a response appropriate to shape the kinetics of neurotransmission during a wide range of firing patterns.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696197/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696197/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Qi -- Li, Yulong -- Tsien, Richard W -- K99 DA025143/DA/NIDA NIH HHS/ -- K99 DA025143-01A1/DA/NIDA NIH HHS/ -- R01 MH064070/MH/NIMH NIH HHS/ -- R01 MH064070-08/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2009 Mar 13;323(5920):1448-53. doi: 10.1126/science.1167373. Epub 2009 Feb 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19213879" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Electric Stimulation ; Hippocampus/cytology ; Hydrogen-Ion Concentration ; Ion Transport ; Luminescence ; *Membrane Fusion ; Neurons/*physiology ; Neurotransmitter Agents/metabolism ; Presynaptic Terminals/physiology ; Quantum Dots ; Rats ; Rats, Sprague-Dawley ; Synaptic Membranes/physiology ; *Synaptic Transmission ; Synaptic Vesicles/*physiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Letvin, Norman L -- New York, N.Y. -- Science. 2009 Nov 27;326(5957):1196-8. doi: 10.1126/science.1183278.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. nletvin@bidmc.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965456" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines/immunology ; Animals ; CD4 Lymphocyte Count ; HIV/physiology ; HIV Antibodies/immunology ; HIV Envelope Protein gp120/immunology ; HIV Infections/immunology/*prevention & control/virology ; Humans ; Models, Animal ; Primates ; Randomized Controlled Trials as Topic ; Risk Factors ; Thailand ; United States ; Viral Load ; Virus Replication
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  • 191
    Publication Date: 2009-06-06
    Description: Huntington's disease (HD) is caused by a polyglutamine repeat in the protein huntingtin (Htt) with mutant Htt (mHtt) expressed throughout the body and similarly in all brain regions. Yet, HD neuropathology is largely restricted to the corpus striatum. We report that the small guanine nucleotide-binding protein Rhes, which is localized very selectively to the striatum, binds physiologically to mHtt. Using cultured cells, we found Rhes induces sumoylation of mHtt, which leads to cytotoxicity. Thus, Rhes-mHtt interactions can account for the localized neuropathology of HD.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745286/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745286/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Subramaniam, Srinivasa -- Sixt, Katherine M -- Barrow, Roxanne -- Snyder, Solomon H -- DA00074/DA/NIDA NIH HHS/ -- MH18501/MH/NIMH NIH HHS/ -- R37 MH018501/MH/NIMH NIH HHS/ -- R37 MH018501-40/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2009 Jun 5;324(5932):1327-30. doi: 10.1126/science.1172871.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19498170" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Death ; Cell Line ; Cell Survival ; Corpus Striatum/metabolism ; GTP-Binding Proteins/*metabolism ; Humans ; Mice ; Mice, Transgenic ; Mutant Proteins/metabolism ; Nerve Tissue Proteins/chemistry/*metabolism ; Nuclear Proteins/chemistry/*metabolism ; PC12 Cells ; RNA Interference ; Rats ; Recombinant Fusion Proteins/metabolism ; SUMO-1 Protein/genetics/metabolism ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Substrate Specificity
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, Allen S -- New York, N.Y. -- Science. 2009 May 29;324(5931):1140. doi: 10.1126/science.324_1140a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Food, Agricultural, and Natural Resource Sciences, University of Minnesota, St. Paul, MN 55108-6074, USA. aslevine@umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478164" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture/education/legislation & jurisprudence ; *Research ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Purnell, Beverly A -- Hines, Pamela J -- New York, N.Y. -- Science. 2009 Jun 26;324(5935):1661. doi: 10.1126/science.324_1661.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19556495" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biomedical Research ; Humans ; Interdisciplinary Communication ; Neoplastic Stem Cells ; *Stem Cells ; United States ; United States Food and Drug Administration
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  • 194
    Publication Date: 2009-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2009 Dec 11;326(5959):1464. doi: 10.1126/science.326.5959.1464.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20007868" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; Animal Rights ; Animals ; *Anthrax ; *Biomedical Research/economics ; *Euthanasia, Animal ; Financing, Government ; Oklahoma ; *Papio ; Research Support as Topic ; United States ; *Universities
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  • 195
    Publication Date: 2009-08-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2009 Aug 21;325(5943):927. doi: 10.1126/science.325_927a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19696320" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/organization & administration ; Financing, Government ; Global Health ; Health Care Reform/organization & administration ; National Institutes of Health (U.S.)/economics/*organization & administration ; Research Support as Topic ; United States
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  • 196
    Publication Date: 2009-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2009 Jun 12;324(5933):1377. doi: 10.1126/science.324_1377a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19520931" target="_blank"〉PubMed〈/a〉
    Keywords: Emigration and Immigration ; *Foreign Professional Personnel ; Humans ; *Research Personnel ; *Students ; *Travel ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-05-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2009 May 8;324(5928):707. doi: 10.1126/science.324_707.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19423786" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Containment of Biohazards ; *Laboratories ; *Microbiology ; *Military Medicine ; *Security Measures ; United States
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  • 198
    Publication Date: 2009-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2009 Jul 17;325(5938):250-1. doi: 10.1126/science.325_250a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19608881" target="_blank"〉PubMed〈/a〉
    Keywords: Genetics, Medical/history ; History, 20th Century ; History, 21st Century ; Human Genome Project/history ; Molecular Biology/history ; National Institutes of Health (U.S.)/economics/*organization & administration ; United States
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  • 199
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2009 Jul 3;325(5936):28-30. doi: 10.1126/science.325_28.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19574366" target="_blank"〉PubMed〈/a〉
    Keywords: Academic Medical Centers/economics/*ethics/legislation & jurisprudence ; *Conflict of Interest ; *Disclosure ; *Faculty ; Financing, Government ; Government Regulation ; National Institutes of Health (U.S.)/*economics ; Private Sector/economics/ethics ; Research Personnel/economics/*ethics/legislation & jurisprudence ; Research Support as Topic/ethics ; United States
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  • 200
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, Virginia -- New York, N.Y. -- Science. 2009 Dec 4;326(5958):1340-1. doi: 10.1126/science.326.5958.1340.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965733" target="_blank"〉PubMed〈/a〉
    Keywords: Alaska ; Animals ; *Ecosystem ; *Fisheries/legislation & jurisprudence/methods/statistics & numerical data ; *Gadiformes/physiology ; Oceans and Seas ; Population Dynamics ; Reproduction ; United States
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