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  • Artikel  (143)
  • United States  (81)
  • Molecular Weight  (39)
  • Mutation  (25)
  • American Association for the Advancement of Science (AAAS)  (143)
  • American Association for the Advancement of Science
  • American Institute of Physics
  • American Institute of Physics (AIP)
  • 1985-1989  (143)
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  • 1985  (143)
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  • Artikel  (143)
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  • American Association for the Advancement of Science (AAAS)  (143)
  • American Association for the Advancement of Science
  • American Institute of Physics
  • American Institute of Physics (AIP)
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  • 1
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    Nutrition report and the Academy (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1985 Dec 20;230(4732):1324-6, 1410.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071054" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; *Nutritional Physiological Phenomena ; Nutritional Requirements ; *Societies, Scientific ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Research costs (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-06-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1985 Jun 7;228(4704):1142, 1144.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001934" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): National Institutes of Health (U.S.) ; *Research Support as Topic ; United States ; Universities/economics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-15
    Beschreibung: A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3' to the env gene on the HTLV-III genome. The presence of antibodies to p27 in virus-exposed individuals indicated that this gene is functional in the natural host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allan, J S -- Coligan, J E -- Lee, T H -- McLane, M F -- Kanki, P J -- Groopman, J E -- Essex, M -- 2T32-CA09031/CA/NCI NIH HHS/ -- CA23885/CA/NCI NIH HHS/ -- CA37466/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Nov 15;230(4727):810-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2997921" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*immunology/microbiology ; Amino Acid Sequence ; Animals ; Antibodies, Viral/*immunology ; Antibody Formation ; Antigens, Viral/*immunology ; Deltaretrovirus/genetics/*immunology ; Electrophoresis, Polyacrylamide Gel ; Haplorhini/microbiology ; Humans ; Male ; Molecular Weight ; Repetitive Sequences, Nucleic Acid
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-31
    Beschreibung: Antibodies from the serum of patients with the acquired immune deficiency syndrome (AIDS) or with the AIDS-related complex and from the serum of seropositive healthy homosexuals, recognize two major glycoproteins in cells infected with human T-cell lymphotropic virus type III (HTLV III). These glycoproteins, gp160 and gp120, are encoded by the 2.5-kilobase open reading frame located in the 3' end of the HTLV-III genome, as determined by amino terminus sequence analysis of the radiolabeled forms of these proteins. It is hypothesized that gp160 and gp120 represent the major species of virus-encoded envelope gene products for HTLV-III.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allan, J S -- Coligan, J E -- Barin, F -- McLane, M F -- Sodroski, J G -- Rosen, C A -- Haseltine, W A -- Lee, T H -- Essex, M -- 2T32-CA09031/CA/NCI NIH HHS/ -- CA 13885/CA/NCI NIH HHS/ -- CA 37466/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 May 31;228(4703):1091-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2986290" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*immunology ; Amino Acid Sequence ; Antibodies, Viral/immunology ; Antigens, Viral/genetics/*immunology ; Base Sequence ; Deltaretrovirus/*immunology ; Genes, Viral ; Glycoproteins/genetics/immunology ; Humans ; Molecular Weight ; Tunicamycin/pharmacology ; Viral Envelope Proteins/genetics/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    "Alz 50" recognizes an Alzheimer's protein (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barnes, D M -- New York, N.Y. -- Science. 1985 Dec 13;230(4731):1260.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071048" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alzheimer Disease/*diagnosis ; Antibodies, Monoclonal ; Humans ; Molecular Weight ; Nerve Tissue Proteins/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-31
    Beschreibung: In this study, two glycoproteins (gp160 and gp120) that are encoded by human T-cell lymphoma virus type III (HTLV-III) were the antigens most consistently recognized by antibodies found in patients with the acquired immune deficiency syndrome (AIDS) and with the AIDS-related complex (ARC) and in healthy homosexual males. The techniques used to detect the glycoproteins were radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (RIP/SDS-PAGE). Although most antibody-positive samples from ARC patients and from healthy homosexual males also reacted with the virus core protein p24, less than half of the AIDS patients revealed a positive band with p24 under the same conditions. The ability to detect antibodies against a profile of both the major env gene encoded antigens and the gag gene encoded antigens suggests that the RIP/SDS-PAGE may be a valuable confirmatory assay for establishing the presence or absence of antibodies to HTLV-III in human serum samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barin, F -- McLane, M F -- Allan, J S -- Lee, T H -- Groopman, J E -- Essex, M -- 2T32-CA09031/CA/NCI NIH HHS/ -- CA 13885/CA/NCI NIH HHS/ -- CA 37466/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 May 31;228(4703):1094-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2986291" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*immunology/microbiology ; Antibodies, Viral/*immunology ; Antibody Specificity ; Antigens, Viral/*immunology ; Deltaretrovirus/*immunology ; Electrophoresis, Polyacrylamide Gel ; Humans ; Immunologic Techniques ; Molecular Weight ; Viral Envelope Proteins/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    New university-industry pact signed (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barnes, D M -- New York, N.Y. -- Science. 1985 Dec 13;230(4731):1255-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071045" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Drug Industry ; Italy ; *Neurobiology ; Research Support as Topic ; United States ; *Universities
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Evolution of bunyaviruses by genome reassortment in dually infected mosquitoes (Aedes triseriatus) (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-01
    Beschreibung: Aedes triseriatus mosquitoes became dually infected after ingesting two mutants of LaCrosse (LAC) virus simultaneously or after ingesting, by interrupted feeding, the two viruses sequentially within a 2-day period. After 2 weeks of incubation, approximately 25 percent of the vectors contained new virus genotypes as the result of RNA segment reassortment. New viruses were transmitted when the mosquitoes fed on mice. Viruses ingested more than 2 days after the initial infecting virus did not cause superinfection of the mosquito vectors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beaty, B J -- Sundin, D R -- Chandler, L J -- Bishop, D H -- AI 15400/AI/NIAID NIH HHS/ -- AI 19688/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):548-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048949" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aedes/*microbiology ; Animals ; Blood ; Bunyaviridae/*genetics ; Genotype ; Insect Vectors ; Mutation ; Phenotype ; RNA, Viral/analysis ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    The mosaic genome of warm-blooded vertebrates (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-24
    Beschreibung: Most of the nuclear genome of warm-blooded vertebrates is a mosaic of very long (much greater than 200 kilobases) DNA segments, the isochores; these isochores are fairly homogeneous in base composition and belong to a small number of major classes distinguished by differences in guanine-cytosine (GC) content. The families of DNA molecules derived from such classes can be separated and used to study the genome distribution of any sequence which can be probed. This approach has revealed (i) that the distribution of genes, integrated viral sequences, and interspersed repeats is highly nonuniform in the genome, and (ii) that the base composition and ratio of CpG to GpC in both coding and noncoding sequences, as well as codon usage, mainly depend on the GC content of the isochores harboring the sequences. The compositional compartmentalization of the genome of warm-blooded vertebrates is discussed with respect to its evolutionary origin, its causes, and its effects on chromosome structure and function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernardi, G -- Olofsson, B -- Filipski, J -- Zerial, M -- Salinas, J -- Cuny, G -- Meunier-Rotival, M -- Rodier, F -- New York, N.Y. -- Science. 1985 May 24;228(4702):953-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001930" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Composition ; Base Sequence ; Biological Evolution ; Centrifugation, Density Gradient ; Chickens/*genetics ; Chromosome Banding ; Codon ; Cytosine/analysis ; DNA/analysis/*genetics ; DNA Replication ; DNA, Viral/genetics ; Gene Amplification ; *Genes ; Genes, Viral ; Guanine/analysis ; Humans ; Mammals/*genetics ; Mice/genetics ; Mutation ; Rabbits/genetics ; Recombination, Genetic ; Repetitive Sequences, Nucleic Acid ; Xenopus/*genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing-dependent reaction (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-24
    Beschreibung: The in vitro splicing reactions of pre-messenger RNA (pre-mRNA) in a yeast extract were analyzed by glycerol gradient centrifugation. Labeled pre-mRNA appears in a 40S peak only if the pre-mRNA undergoes the first of the two partial splicing reactions. RNA analysis after extraction of glycerol gradient fractions shows that lariat-form intermediates, molecules that occur only in mRNA splicing, are found almost exclusively in this 40S complex. Another reaction intermediate, cut 5' exon RNA, can also be found concentrated in this complex. The complex is stable even in 400 mM KCl, although at this salt concentration, it sediments at 35S and is clearly distinguishable from 40S ribosomal subunits. This complex, termed a "spliceosome," is thought to contain components necessary for mRNA splicing; its existence can explain how separated exons on pre-mRNA are brought into contact.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brody, E -- Abelson, J -- New York, N.Y. -- Science. 1985 May 24;228(4702):963-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3890181" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actins/genetics ; Base Sequence ; Centrifugation, Density Gradient ; Mutation ; Nucleic Acid Conformation ; Nucleic Acid Precursors/*genetics/metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Fungal/*genetics/metabolism ; RNA, Messenger/*genetics/metabolism ; Saccharomyces cerevisiae/*genetics/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 11
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    Animal welfare legislation (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-06
    Beschreibung: In the article "Rates of elementary reactions: Measurement and applications" by F. Kaufman (25 Oct., p. 393), the equation in column 2 on page 394 should have read: [See formula in Source Pdf.]〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, G E Jr -- New York, N.Y. -- Science. 1985 Dec 6;230(4730):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071038" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Animal Experimentation ; *Animal Welfare ; Animals ; *Animals, Laboratory ; *Federal Government ; *Government Regulation ; *Legislation, Medical ; National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    Selective inhibition of fibronectin-mediated cell adhesion by monoclonal antibodies to a cell-surface glycoprotein (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-06-21
    Beschreibung: Fibroblasts possess several distinct mechanisms that control cellular adhesion to extracellular matrix macromolecules. Monoclonal antibodies to a 140-kilodalton (kD) cell surface glycoprotein inhibited the adhesion of fibroblastic Chinese hamster ovary cells to fibronectin-coated substrata but did not inhibit adhesion to substrata coated with vitronectin, laminin, serum, or other adhesive macromolecules. Thus the 140-kD glycoprotein appears to be involved in the fibronectin-mediated adhesion mechanism but not in other adhesion processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, P J -- Juliano, R L -- GM26165/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 21;228(4706):1448-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012302" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal ; *Cell Adhesion ; Cell Membrane/immunology/*metabolism ; Cells, Cultured ; Cricetinae ; Cricetulus ; Fibroblasts/metabolism ; Fibronectins/*metabolism ; Glycoproteins/immunology/*metabolism ; Molecular Weight
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    The unusual varl gene of yeast mitochondrial DNA (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-06-28
    Beschreibung: The var1 gene specifies the only mitochondrial ribosomal protein known to be encoded by yeast mitochondrial DNA. The gene is unusual in that its base composition is nearly 90 percent adenine plus thymine. It and its expression product show a strain-dependent variation in size of up to 7 percent; this variation does not detectably interfere with function. Furthermore, var1 is an expandable gene that participates in a novel recombinational event resembling gene conversion whereby shorter alleles are preferentially converted to longer ones. The remarkable features of var1 indicate that it may have evolved by a mechanism analogous to exon shuffling, although no introns are actually present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butow, R A -- Perlman, P S -- Grossman, L I -- GM-22525/GM/NIGMS NIH HHS/ -- GM-26546/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 28;228(4707):1496-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2990030" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alleles ; Base Sequence ; Biological Evolution ; DNA Restriction Enzymes/metabolism ; DNA, Mitochondrial/*analysis ; *Genes, Fungal ; Mutation ; Neurospora/*genetics ; Polymorphism, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    A Plasmodium falciparum antigen that binds to host erythrocytes and merozoites (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-01
    Beschreibung: Antigens that bind to erythrocytes were identified in the supernatant fluids of a cultured human malaria parasite (Plasmodium falciparum). A 175-kilodalton (175K) antigen bound only to erythrocytes susceptible to invasion. The 175K antigen from the Camp or the FCR-3 strain also bound to merozoites. However, the antigen did not bind to merozoites when merozoites and supernatant antigens were from different strains unless proteinase inhibitors were present. Moreover, erythrocytes coated with supernatant antigens from the Camp or FCR-3 strain were invaded normally by merozoites of the homologous strain but were partially resistant to invasion by merozoites of the heterologous strain. The 175K antigen may be a receptor acting as a "bridge" between erythrocytes and merozoites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Camus, D -- Hadley, T J -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):553-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3901257" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, Protozoan/*metabolism ; Chymotrypsin/metabolism ; Electrophoresis, Polyacrylamide Gel ; Erythrocytes/*metabolism ; Guinea Pigs ; Humans ; Macaca mulatta ; Molecular Weight ; Neuraminidase/metabolism ; Plasmodium falciparum/*immunology ; Protease Inhibitors/pharmacology ; Rabbits ; Trypsin/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    OMB directive will cost NIH loss of 1500 grants (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-02-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Feb 1;227(4686):498.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966158" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    The epidemiology of AIDS: current status and future prospects (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-27
    Beschreibung: The reported incidence of acquired immune deficiency syndrome (AIDS) continues to increase in countries throughout the world. On the basis of a polynomial model for extrapolation, the cumulative number of cases diagnosed and reported since 1981 in the United States is expected to double during the next year with over 12,000 additional cases projected to be diagnosed by July 1986. The annual incidence rates for single (never-married) men in Manhattan and San Francisco, intravenous drug users in New York City and New Jersey, and persons with hemophilia A ranged from 261 to 350 per 100,000 population during 1984. For single men aged 25 to 44 years in Manhattan and San Francisco, AIDS was the leading cause of premature mortality in 1984 as measured by years of potential life lost. Infection with HTLV-III/LAV is considerably more common than reported AIDS in high-risk populations and can persist at least for several years, so the presence of specific antibody should be considered presumptive evidence of current infection. The screening of donated blood and plasma for antibody to HTLV-III/LAV and use of safer clotting factor concentrates should greatly reduce HTLV-III/LAV transmission through blood and blood products. Most HTLV-III/LAV infections occur through sexual transmission, use of contaminated needles, and as a result of infected mothers passing the virus to newborns. Continued research commitment is needed to develop an HTLV-III/LAV vaccine and therapy for this infection. In the interim, widespread community efforts are needed to minimize transmission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Curran, J W -- Morgan, W M -- Hardy, A M -- Jaffe, H W -- Darrow, W W -- Dowdle, W R -- New York, N.Y. -- Science. 1985 Sep 27;229(4720):1352-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2994217" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency ; Syndrome/complications/*epidemiology/microbiology/mortality/prevention & ; control/transmission ; Adult ; Antibodies, Viral/immunology ; Blood Donors ; California ; Child ; Deltaretrovirus/immunology ; Female ; Hemophilia A/complications ; Homosexuality ; Humans ; Infant ; Infant, Newborn ; Male ; New York City ; Pregnancy ; Retroviridae Infections/epidemiology ; Risk ; Sarcoma, Kaposi/complications ; Substance-Related Disorders/complications ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    Activated proto-onc genes: sufficient or necessary for cancer? (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-10
    Beschreibung: Proto-onc genes are normal cellular genes that are related to the transforming (onc) genes of retroviruses. Because of this relationship these genes are now widely believed to be potential cancer genes. In some tumors, proto-onc genes are mutated or expressed more than in normal cells. Under these conditions, proto-onc genes are hypothesized to be active cancer genes in one of two possible ways: The one gene-one cancer hypothesis suggests that one activated proto-onc gene is sufficient to cause cancer. The multigene-one cancer hypothesis suggests that an activated proto-onc gene is a necessary but not a sufficient cause of cancer. However, mutated or transcriptionally activated proto-onc genes are not consistently associated with the tumors in which they are occasionally found and do not transform primary cells. Further, no set of an activated proto-onc gene and a complementary cancer gene with transforming function has yet been isolated from a tumor. Thus, there is still no proof that activated proto-onc genes are sufficient or even necessary to cause cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duesberg, P H -- CA 11426/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 May 10;228(4700):669-77.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3992240" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Transformation, Neoplastic/metabolism ; Chickens ; DNA, Neoplasm/genetics ; Genes, Viral ; Humans ; Kirsten murine sarcoma virus/genetics ; Lymphoma/genetics ; Melanoma/genetics ; Mice ; Mutation ; Neoplasms/etiology/*genetics ; *Oncogenes ; Plasmacytoma/genetics ; Rats ; Retroviridae/genetics ; Sarcoma, Experimental/genetics ; Transduction, Genetic ; Translocation, Genetic ; Tumor Virus Infections/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 18
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    Atrotoxin: a specific agonist for calcium currents in heart (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-07-12
    Beschreibung: A specific label for voltage-dependent calcium channels is essential for the isolation and purification of the membrane protein that constitutes the calcium channel and for a better understanding of its function. A fraction of Crotalus atrox that increases voltage-dependent calcium currents in single, dispersed guinea pig ventricular cells was isolated. In the doses used, neither sodium nor potassium currents were changed. The fraction was active in the absence of detectable phospholipase or protease activity, and the active component, designated atrotoxin, produced its effect rapidly and reversibly. The effect was produced by extracellular but not intracellular application of the agent. The increase in Ca2+ current was blocked by the Ca2+ channel blockers cobalt and nitrendipine. The active fraction completely blocked specific [3H]nitrendipine binding to guinea pig ventricular membrane preparations. The inhibition of nitrendipine binding by atrotoxin was apparently via an allosteric mechanism. Thus atrotoxin was shown to bind to the Ca2+ channel and to act as a specific Ca2+ channel agonist.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamilton, S L -- Yatani, A -- Hawkes, M J -- Redding, K -- Brown, A M -- 1R01 HL3293S/HL/NHLBI NIH HHS/ -- 1R01-HL33662-01/HL/NHLBI NIH HHS/ -- 5R01-HL25145-05/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Jul 12;229(4709):182-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3160111" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials/drug effects ; Animals ; Calcium/*metabolism ; Cell Membrane/metabolism ; Crotalid Venoms/*pharmacology ; Dose-Response Relationship, Drug ; Guinea Pigs ; In Vitro Techniques ; Molecular Weight ; Myocardium/*metabolism ; Nifedipine/analogs & derivatives/metabolism ; Nitrendipine ; Potassium/metabolism ; Rats ; Sodium/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 19
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    Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-01
    Beschreibung: The 21-base pair repeat elements of the SV40 promoter contain six tandem copies of the GGGCGG hexanucleotide (GC-box), each of which can bind, with varying affinity, to the cellular transcription factor, Sp1. In vitro SV40 early RNA synthesis is mediated by interaction of Sp1 with GC-boxes I, II, and III, whereas transcription in the late direction is mediated by binding to GC-boxes III, V, and VI.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gidoni, D -- Kadonaga, J T -- Barrera-Saldana, H -- Takahashi, K -- Chambon, P -- Tjian, R -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):511-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996137" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Autoradiography ; Base Sequence ; Binding Sites ; DNA-Binding Proteins/*metabolism ; Deoxyribonuclease I/metabolism ; Electrophoresis, Polyacrylamide Gel ; Gene Expression Regulation ; Mutation ; Pregnancy Proteins/*metabolism ; RNA, Messenger/analysis ; RNA, Viral/biosynthesis ; Simian virus 40/*genetics ; Sp1 Transcription Factor ; Templates, Genetic ; Transcription Factors/*metabolism ; *Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    Broader commitment laws sought (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Dec 13;230(4731):1253-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071044" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Commitment of Mentally Ill ; Humans ; Mental Disorders/*therapy ; *Mentally Ill Persons ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 21
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    NIH to award 2200 new grants (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Sep 6;229(4717):947.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023717" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): National Institutes of Health (U.S.) ; *Research Support as Topic/economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 22
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    "Right-to-life" scores new victory at AID (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Sep 13;229(4718):1065-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4035346" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Body Temperature ; Cervix Mucus ; Disclosure ; *Family Planning Services ; Federal Government ; Female ; Government Agencies ; Humans ; Internationality ; Male ; Natural Family Planning Methods ; Ovulation ; *Research Support as Topic ; United States ; pressure, has decided to permit grants to natural family planning groups that do ; not adhere to long-standing AID policy that clients be provided with information ; on all methods of contraception. This step is at odds with domestic and United ; Nations policy, and it violates the medical ethic that a patient should be ; informed of all medically approved options. A brief review of the current state ; of U.S. family planning policy and the controversy surrounding it concludes with ; Holden's observation that the issue is likely to be further politicized.
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 23
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    New biotech review board planned (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-08-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):736-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3860953" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Advisory Committees ; *Federal Government ; Genetic Engineering/*standards ; *Government Regulation ; Humans ; Legislation as Topic ; National Institutes of Health (U.S.) ; United States ; United States Food and Drug Administration ; regulate developments in genetic engineering, have influenced the field through ; the review activities of their Recombinant DNA Advisory Committee (RAC). Recent ; challenges to RAC's prestige and authority have emerged from within the ; Department of Health and Human Services. A proposed Biotechnology Science Board, ; under the Assistant Secretary for Health, would exercise broad authority over ; biotechnology research, including clinical trials of human gene therapy. Food and ; Drug Administration officials have also expressed a strong interest in reviewing ; these research protocols, which NIH considered within its purview. As a result of ; this political maneuvering, publication of NIH's revised gene therapy guidelines ; has been delayed, and RAC may find itself functioning solely as an in-house ; advisory body to NIH.
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 24
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    NIMH to reorganize extramural research (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-07-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Jul 26;229(4711):362, 367.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2990049" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *National Institute of Mental Health (U.S.)/organization & administration ; *Research Support as Topic ; United States ; *United States Substance Abuse and Mental Health Services ; Administration/organization & administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 25
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    Deal struck on NIH grants (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 May 24;228(4702):970.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001931" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 26
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    NIH bills moving through Congress (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-07-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Jul 5;229(4708):33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012309" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Legislation as Topic ; *National Institutes of Health (U.S.) ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 27
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    NIH role in biotechnology debated (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-07-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Jul 12;229(4709):147-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012315" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *National Institutes of Health (U.S.) ; Research ; Research Support as Topic ; *Technology ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 28
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    Gene therapy guidelines revised (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 May 3;228(4699):561-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3856951" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Deaminase/deficiency ; Advisory Committees ; Animal Experimentation ; Animals ; Dogs ; Ethics Committees, Research ; Federal Government ; Genetic Diseases, Inborn ; *Genetic Engineering ; *Government Regulation ; Humans ; Mice ; National Institutes of Health (U.S.) ; United States ; Recombinant DNA Advisory Committee (RAC), has revised its draft guidelines, ; published in the 22 January 1985 Federal Register, for researchers submitting ; protocols for human gene therapy experiments. The major revisions in the "Points ; to Consider" are the elimination of a required response in the protocol to ; complex social and ethical questions and a greater flexibility in requirements ; for animal testing prior to human experimentation. Other modifications include ; provisions for public review of protocols, a requirement of patient agreement to ; long term follow-up and autopsy, and the limiting of review to only somatic cell ; therapy for the present. The stages of protocol review will involve local ethics ; and biosafety committees, then the Working Group, the full RAC, and finally the ; director of NIH.
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 29
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    Rescue of the Drosophila phototransduction mutation trp by germline transformation (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-29
    Beschreibung: Phototransduction is the process by which light-stimulated photoreceptor cells of the visual system send electrical signals to the nervous system. Many of the steps that follow the initial event in phototransduction, absorption of light by rhodopsin, are ill-defined. The fruitfly, Drosophila melanogaster, provides a means to dissect phototransduction genetically. Mutations such as transient receptor potential (trp) affect intermediate steps in phototransduction. In order to facilitate molecular studies of phototransduction, the trp gene was isolated and its identity was confirmed by complementing the mutant trpCM allele of the trp gene by P-element mediated germline transformation of a 7.1-kilobase DNA fragment. Expression of the trp gene begins late in pupal development and appears to be limited to the eyes and ocelli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Montell, C -- Jones, K -- Hafen, E -- Rubin, G -- New York, N.Y. -- Science. 1985 Nov 29;230(4729):1040-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3933112" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; DNA/genetics ; Drosophila melanogaster/*genetics/physiology ; Gene Expression Regulation ; Genes ; Mutation ; Ocular Physiological Phenomena ; RNA, Messenger/genetics ; *Vision, Ocular
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 30
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    AIDS trends: projections from limited data (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1985 Nov 29;230(4729):1018, 1020-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4059918" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/diagnosis/*epidemiology/transmission ; Forecasting ; Homosexuality ; Humans ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 31
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    AIDS therapy: new push for clinical trials (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1985 Dec 20;230(4732):1355-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2999981" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/microbiology/*therapy ; Clinical Trials as Topic ; Deltaretrovirus/immunology ; Humans ; National Institutes of Health (U.S.) ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 32
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    AIDS virology: a battle on many fronts (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):518-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2413546" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/diagnosis/*microbiology ; Antibodies, Monoclonal ; Antibodies, Viral/analysis ; Antigens, Viral/analysis/immunology ; Cell Line ; Cross Reactions ; Culture Techniques/methods ; Cytopathogenic Effect, Viral ; Deltaretrovirus/immunology/*isolation & purification ; Homosexuality ; Humans ; Lymphatic Diseases/microbiology ; Microscopy, Electron ; Patents as Topic/legislation & jurisprudence ; RNA-Directed DNA Polymerase/analysis ; Reagent Kits, Diagnostic ; T-Lymphocytes/microbiology ; Terminology as Topic ; United States ; Viral Core Proteins/immunology ; Viral Envelope Proteins/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 33
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    The academy kills a nutrition report (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1985 Oct 25;230(4724):420-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048941" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; National Academy of Sciences (U.S.) ; National Institutes of Health (U.S.) ; *Nutritional Physiological Phenomena ; Nutritional Requirements ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 34
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    USDA may be asked to police animal research (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1985 Nov 15;230(4727):789.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4059911" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Care Committees ; *Animal Experimentation ; Animals ; *Animals, Laboratory ; Dogs ; Federal Government ; *Government Agencies ; *Government Regulation ; National Institutes of Health (U.S.) ; Primates ; Research ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 35
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    Measles virus matrix protein synthesized in a subacute sclerosing panencephalitis cell line (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-06-07
    Beschreibung: Measles virus generally produces acute illness. Rarely, however, persistent infection of brain cells occurs, resulting in a chronic and fatal neurological disease, subacute sclerosing panencephalitis (SSPE). Evidence indicates that expression of the measles virus matrix protein is selectively restricted in this persistent infection, but the mechanism underlying this restriction has not been identified. Defective translation of matrix messenger RNA has been described in one SSPE cell line. This report presents evidence that in a different SSPE tissue culture cell line IP-3-Ca, the matrix protein is synthesized but fails to accumulate. A general scheme is proposed to reconcile the different levels at which restriction of matrix protein has been observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sheppard, R D -- Raine, C S -- Bornstein, M B -- Udem, S A -- CA13330-12/CA/NCI NIH HHS/ -- NS 08952/NS/NINDS NIH HHS/ -- NS 11920/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 7;228(4704):1219-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001938" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Gene Expression Regulation ; Humans ; Hydrolysis ; Measles virus/genetics/growth & development/*metabolism ; Molecular Weight ; Mutation ; Protein Processing, Post-Translational ; Subacute Sclerosing Panencephalitis/*microbiology ; Viral Matrix Proteins ; Viral Proteins/*biosynthesis/genetics ; Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 36
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    Heterologous protein secretion from yeast (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R A -- Duncan, M J -- Moir, D T -- New York, N.Y. -- Science. 1985 Sep 20;229(4719):1219-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3939723" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cattle ; Chymosin/*secretion ; Cloning, Molecular ; Cytoplasm/enzymology ; Enzyme Activation ; Enzyme Precursors/*secretion ; Fungal Proteins/secretion ; Glycosylation ; Mutation ; Plasmids ; Protein Processing, Post-Translational ; Recombinant Fusion Proteins/secretion ; Saccharomyces cerevisiae/enzymology/*genetics ; Solubility
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 37
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    Court hears suit on biowarfare laboratory (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R Jeffrey -- New York, N.Y. -- Science. 1985 May 17;228(4701):827-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643758" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Biological Warfare ; Containment of Biohazards ; *DNA, Recombinant ; Ecology ; Federal Government ; Government ; Government Regulation ; Hazardous Substances ; Jurisprudence ; *Public Policy ; Social Control, Formal ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 38
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    The 36-kilodalton substrate of pp60v-src is myristylated in a transformation-sensitive manner (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-01
    Beschreibung: A primary intracellular substrate for pp60v-src kinase in a variety of avian and mammalian cells is a protein of 34 to 39 kilodaltons (kD). After incubation of chicken embryo fibroblasts (CEF) with [3H]myristic acid for 4 hours, the 36-kD protein contained covalently bound myristic acid by several criteria: (i) the radioactively labeled material comigrated with the 36-kD protein on sodium dodecyl sulfate-polyacrylamide gels in one and two dimensions, (ii) the labeled material was insoluble in chloroform-methanol, and (iii) radioactively labeled myristate could be recovered from the purified 36-kD protein. The resistance of the acyl fatty acid moiety to hydrolysis by hydroxylamine suggested that the covalent linkage to the 36-kD protein may be through an amide linkage. The [3H]myristic-acid labeling of the 36-kD protein in Rous sarcoma virus-transformed CEF showed a reduction of up to 45 percent when compared to an identical amount of 36-kD protein derived from normal cells; this reduction was not due to general changes in myristic acid metabolism in transformed cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soric, J -- Gordon, J A -- CA-15823/CA/NCI NIH HHS/ -- CA-35378/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):563-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996139" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Avian Sarcoma Viruses ; *Cell Transformation, Viral ; Chick Embryo ; Electrophoresis, Polyacrylamide Gel ; Hydrolysis ; Hydroxylamine ; Hydroxylamines/pharmacology ; Methionine/metabolism ; Molecular Weight ; Myristic Acid ; Myristic Acids/*metabolism ; Oncogene Protein pp60(v-src) ; Retroviridae Proteins/*metabolism ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 39
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    Heart panel's conclusions (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-02-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinberg, D -- New York, N.Y. -- Science. 1985 Feb 8;227(4687):582.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3969549" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cholesterol/*blood ; Cholesterol, Dietary/adverse effects ; Coronary Disease/*etiology/prevention & control ; Humans ; National Institutes of Health (U.S.) ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 40
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    Circulating autoantibodies to the 200,000-dalton protein of neurofilaments in the serum of healthy individuals (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-31
    Beschreibung: There is substantial evidence that human serum contains antibodies to many autoantigens. For example, all healthy people have autoantibodies (immunoglobulin M) to some undefined brain antigens. In this study immunoblots and immunohistochemical staining were used to detect antibodies to neural tissues in serum samples from 200 healthy people and 200 patients with various neurological diseases. Ninety-nine percent of the 400 subjects had serum immunoglobulin M and 95 percent had immunoglobulin G that bound to a 200-kilodalton protein in homogenates of neural tissues. In most cases there were no antibodies to anything else in the homogenates. The 200-kilodalton protein was the heaviest of the neurofilament triplet proteins. These observations do not support a role for antibodies to the 200-kilodalton protein of neurofilaments in the pathogenesis of neurological diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stefansson, K -- Marton, L S -- Dieperink, M E -- Molnar, G K -- Schlaepfer, W W -- Helgason, C M -- New York, N.Y. -- Science. 1985 May 31;228(4703):1117-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4039466" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Autoantibodies/*analysis ; Cytoskeleton/*immunology ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Intermediate Filament Proteins/*immunology ; Molecular Weight ; Nerve Tissue Proteins/immunology ; Nervous System Diseases/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 41
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    The LDL receptor gene: a mosaic of exons shared with different proteins (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-17
    Beschreibung: The multifunctional nature of coated pit receptors predicts that these proteins will contain multiple domains. To establish the genetic basis for these domains (LDL) receptor. This gene is more than 45 kilobases in length and contains 18 exons, most of which correlate with functional domains previously defined at the protein level. Thirteen of the 18 exons encode protein sequences that are homologous to sequences in other proteins: five of these exons encode a sequence similar to one in the C9 component of complement; three exons encode a sequence similar to a repeat sequence in the precursor for epidermal growth factor (EGF) and in three proteins of the blood clotting system (factor IX, factor X, and protein C); and five other exons encode nonrepeated sequences that are shared only with the EGF precursor. The LDL receptor appears to be a mosaic protein built up of exons shared with different proteins, and it therefore belongs to several supergene families.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450672/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450672/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sudhof, T C -- Goldstein, J L -- Brown, M S -- Russell, D W -- HL 01287/HL/NHLBI NIH HHS/ -- HL 20948/HL/NHLBI NIH HHS/ -- HL 31346/HL/NHLBI NIH HHS/ -- P01 HL020948/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1985 May 17;228(4701):815-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2988123" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; *Base Sequence ; Cloning, Molecular ; Complement C9/genetics ; Dna ; Endonucleases ; Epidermal Growth Factor/genetics ; Factor IX/genetics ; Factor X/genetics ; *Genes ; Glycoproteins/genetics ; Humans ; Hyperlipoproteinemia Type II/genetics ; Molecular Weight ; Protein C ; Protein Precursors ; Protein Processing, Post-Translational ; Receptors, LDL/*genetics ; Repetitive Sequences, Nucleic Acid ; Single-Strand Specific DNA and RNA Endonucleases ; Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 42
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    New momentum for drug export bill (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Nov 22;230(4728):926.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4059915" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Drug Industry ; *Legislation, Drug ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 43
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    Ownership of cells raises sticky issues (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Nov 15;230(4727):789.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4059910" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Biomedical Research ; *Cell Line ; *Human Body ; Humans ; *Jurisprudence ; Male ; Patents as Topic ; *Patient Rights ; *Tissue and Organ Procurement ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 44
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    Food dyes fuel debate over Delaney (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-08-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):739-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023708" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Food Coloring Agents/*standards ; Humans ; United States ; United States Food and Drug Administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 45
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    Administration divided over OECD biotech plan (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-08-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Marjorie -- New York, N.Y. -- Science. 1985 Aug 30;229(4716):842-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643793" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research ; Containment of Biohazards ; *DNA, Recombinant ; Ecology ; Europe ; Federal Government ; Government ; *Government Regulation ; Hazardous Substances ; *Industry ; *International Cooperation ; *Internationality ; Japan ; *Public Policy ; Research ; *Social Control, Formal ; United States ; and Development (OECD)--which includes the United States, most of its European ; allies, and Japan--have been discussing how to set up international guidelines to ; regulate the emerging biotechnology industry. A May 1985 first draft of the ; guidelines spawned many objections, and now a revised draft, called "Safety and ; Regulations in Biotechnology," has encountered mixed responses from U.S. federal ; agencies. The Environmental Protection Agency generally supports the document, ; but the State Department, Food and Drug Administration, and Department of ; Agriculture have significant objections to its tone and substance, particularly ; in regard to the specificity of safety controls over the commercial development ; of recombinant DNA organisms used in large-scale production and for agricultural ; purposes.
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 46
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    Gene therapy guidelines approved (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):302.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3863254" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Advisory Committees ; DNA, Recombinant/*therapeutic use ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Humans ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 47
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    Generic Valiums clear another hurdle at FDA (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-07-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Jul 26;229(4711):369.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012323" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Diazepam ; Humans ; Therapeutic Equivalency ; United States ; United States Food and Drug Administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 48
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    Generics, Roche joust for Valium market (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-04-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Apr 26;228(4698):472-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3983636" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Diazepam/*supply & distribution ; *Drug Industry ; Therapeutic Equivalency ; United States ; United States Food and Drug Administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 49
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    Rifkin and NIH win in court ruling (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Mar 15;227(4692):1321.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3856320" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Advisory Committees ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Jurisprudence ; *National Institutes of Health (U.S.) ; United States ; United States Environmental Protection Agency ; the District of Columbia ruled that experiments involving the release of ; genetically altered organisms into the environment can proceed, provided that ; their potential ecological effects have been properly evaluated. The ruling has ; been hailed as a victory by both the National Institutes of Health (NIH) and ; Jeremy Rifkin. Rifkin brought suit against NIH in 1983, charging that the agency ; had failed to evaluate adequately the environmental impact of some deliberate ; release experiments. Sun discusses the implications of the judge's ruling. She ; also describes a move by private companies to submit their recombinant DNA ; experiment proposals to the Environmental Protection Agency rather than to NIH, ; which has regulatory authority only over academic researchers.
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 50
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    The vexing problems of vaccine compensation (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-03-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Mar 1;227(4690):1012-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975597" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; *Compensation and Redress ; Federal Government ; Humans ; *Legislation, Medical ; Risk Assessment ; United States ; *Vaccines/adverse effects ; children who are injured by vaccines administered as part of the public health ; campaign against childhood diseases. Blaming increased liability costs, several ; drug companies have stopped production of essential vaccines, raising fears of ; shortages. Proposals that the federal government sponsor a compensation system ; have met with approval from parents of injured children, medical associations, ; and drug companies, although these groups disagree over whether victims should ; retain the right to sue the vaccine manufacturers as an alternative to receiving ; federal compensation. Legislation has been introduced in both houses of Congress ; to establish a compensation program, but Administration opposition is expected to ; the potential expense and the broad range of coverage.
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Agency scraps plan to limit ethylene oxide (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-01-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Jan 25;227(4685):392-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966156" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Ethylene Oxide/adverse effects ; Humans ; Maximum Allowable Concentration ; Time Factors ; United States ; United States Occupational Safety and Health Administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 52
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    Young plans management reforms at FDA (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-01-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Jan 18;227(4684):277-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3880921" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): History, 20th Century ; United States ; United States Food and Drug Administration/*organization & administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 53
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    New directions for the IOM. Interview by Gina Kolata (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thier, S -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):524.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048945" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Delivery of Health Care ; Humans ; *National Academy of Sciences (U.S.) ; *Organizations ; Physicians ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 54
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    Neurotrophic factors (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-07-19
    Beschreibung: In addition to nerve growth factor (NGF), many proteins present in soluble tissue extracts and in the extracellular matrix influence the survival and development of cultured neurons. The structure, synthesis, and mechanism of action of NGF as a neurotrophic factor are considered along with the experiments on the new putative trophic molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thoenen, H -- Edgar, D -- New York, N.Y. -- Science. 1985 Jul 19;229(4710):238-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2409599" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cattle ; Cell Survival ; Cells, Cultured ; Chick Embryo ; Chickens ; Cyclic AMP/physiology ; DNA/genetics ; Extracellular Matrix/physiology ; Humans ; Ion Channels/physiology ; Male ; Mice ; Molecular Weight ; Myocardium/cytology ; Nerve Growth Factors/genetics/isolation & purification/*physiology ; Neurons/physiology ; Protein Precursors/genetics ; RNA, Messenger/metabolism ; Rats ; Receptors, Cell Surface/physiology ; Receptors, Nerve Growth Factor ; Sympathetic Nervous System/cytology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 55
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    Chromosome-sized DNA molecules of Plasmodium falciparum (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-08-16
    Beschreibung: At least seven chromosome-sized DNA molecules (750 to 2000 kilobases in length and one fraction of undetermined molecular weight) from cultured clones and isolates of Plasmodium falciparum have been separated by pulsed-field gradient gel electrophoresis. Whereas asexual blood stages and sexual stages of the same line have identical molecular karyotypes, the length of chromosome-sized DNA molecules among different geographical isolates and several clones derived from a single patient is different. These length alterations of chromosomes are the result of DNA rearrangements that must occur unrelated to sexual differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van der Ploeg, L H -- Smits, M -- Ponnudurai, T -- Vermeulen, A -- Meuwissen, J H -- Langsley, G -- New York, N.Y. -- Science. 1985 Aug 16;229(4714):658-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3895435" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chromosomes/*ultrastructure ; DNA/*isolation & purification ; Electrophoresis, Polyacrylamide Gel/methods ; Molecular Weight ; Plasmodium falciparum/*genetics ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 56
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    Who runs NIH? (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-03-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Mar 29;227(4694):1562-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975626" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Legislation, Medical ; *National Institutes of Health (U.S.)/organization & administration ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 57
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    OMB raid on NIH budget called "outrageous" (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-03-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Mar 1;227(4690):1016-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975598" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Budgets/legislation & jurisprudence ; Legislation, Medical ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 58
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    Biotechnology in pharmaceuticals: the Japanese challenge (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-20
    Beschreibung: The products of biotechnology are being developed for new diagnostics and therapeutics, and it is predicted that they will have great impact on the pharmaceutical industry. In the United States, pharmaceutical companies are incorporating biotechnology into their research and development programs, often with the contractual assistance of small biotechnology firms. Their strongest competition is arising in Japan, where there are now concerted government and industry efforts to expand biotechnology capabilities and to optimize commercialization. Strategies used by the United States and Japan to incorporate biotechnology into their pharmaceutical industries are examined and compared.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dibner, M D -- New York, N.Y. -- Science. 1985 Sep 20;229(4719):1230-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3898361" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Drug Industry/economics ; Economic Competition ; Japan ; Technology, Pharmaceutical/economics/methods/*trends ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 59
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    Function and autoregulation of yeast copperthionein (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-10
    Beschreibung: The CUP1 gene of yeast encodes a small, metallothionein-like protein that binds to and is inducible by copper. A gene replacement experiment shows that this protein protects cells against copper poisoning but is dispensable for normal cellular growth and development throughout the yeast life cycle. The transcription of CUP1 is negatively autoregulated. This feedback mechanism, which is mediated through upstream control sequences, may play an important role in heavy metal homeostasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamer, D H -- Thiele, D J -- Lemontt, J E -- New York, N.Y. -- Science. 1985 May 10;228(4700):685-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3887570" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Carrier Proteins ; Copper/metabolism ; Copper Sulfate ; Enzyme Induction ; Genes, Fungal ; Metallothionein/biosynthesis/genetics/*physiology ; Mutation ; Operon ; Plasmids ; RNA, Messenger/biosynthesis ; Saccharomyces cerevisiae/*enzymology/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 60
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    Mutation to herbicide resistance maps within the psbA gene of Anacystis nidulans R2 (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-13
    Beschreibung: A psbA gene encoding the target of photosystem II herbicide inhibition, the 32,000-dalton thylakoid membrane protein, has been cloned from a mutant of Anacystis nidulans R2, which is resistant to 3-(3,4-dichlorophenyl)-1,1-dimethylurea-(diuron). A cloned DNA fragment from within the coding region of this gene transforms wild-type cells to herbicide resistance, proving that mutation within psbA is responsible for that phenotype. The mutation consists of a single nucleotide change that replaces serine at position 264 of the wild-type protein with alanine in that of the diuron-resistant mutant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Golden, S S -- Haselkorn, R -- New York, N.Y. -- Science. 1985 Sep 13;229(4718):1104-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3929379" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Base Sequence ; Cyanobacteria/*genetics ; Diuron ; Drug Resistance ; Electrophoresis, Polyacrylamide Gel ; *Herbicides ; Membrane Proteins/genetics ; Molecular Weight ; *Mutation ; Phenotype
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 61
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    NIH study (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-02-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoagland, M -- New York, N.Y. -- Science. 1985 Feb 15;227(4688):704.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3969560" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *National Institutes of Health (U.S.)/economics/organization & administration ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 62
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    HHS halts animal experiment (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-08-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Aug 2;229(4712):447-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012324" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Animal Experimentation ; Animal Husbandry/methods ; Animals ; *Animals, Laboratory ; *Craniocerebral Trauma ; Federal Government ; *Government Regulation ; National Institutes of Health (U.S.) ; Papio ; Pennsylvania ; *Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 63
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    Reagan vetoes NIH bill; override is likely (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Nov 29;230(4729):1021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4059919" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): National Institutes of Health (U.S.)/*legislation & jurisprudence ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 64
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    ADAMHA funding pressed (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-01-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Jan 11;227(4683):147-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966149" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; *Mental Disorders ; National Institute of Mental Health (U.S.) ; *Research Support as Topic ; *Substance-Related Disorders ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 65
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    Violence seen as public health issue (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Dec 13;230(4731):1257.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071047" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; Public Health ; United States ; Violence/*physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    IOM presents more nuclear war data (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 1985 Oct 11;230(4722):156.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643807" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Hazardous Substances ; Humans ; Institute of Medicine (U.S.) ; Morbidity ; Mortality ; *Nuclear Warfare ; Public Policy ; *Social Change ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 67
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    Three-dimensional structure of poliovirus at 2.9 A resolution (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-27
    Beschreibung: The three-dimensional structure of poliovirus has been determined at 2.9 A resolution by x-ray crystallographic methods. Each of the three major capsid proteins (VP1, VP2, and VP3) contains a "core" consisting of an eight-stranded antiparallel beta barrel with two flanking helices. The arrangement of beta strands and helices is structurally similar and topologically identical to the folding pattern of the capsid proteins of several icosahedral plant viruses. In each of the major capsid proteins, the "connecting loops" and NH2- and COOH-terminal extensions are structurally dissimilar. The packing of the subunit "cores" to form the virion shell is reminiscent of the packing in the T = 3 plant viruses, but is significantly different in detail. Differences in the orientations of the subunits cause dissimilar contacts at protein-protein interfaces, and are also responsible for two major surface features of the poliovirion: prominent peaks at the fivefold and threefold axes of the particle. The positions and interactions of the NH2- and COOH-terminal strands of the capsid proteins have important implications for virion assembly. Several of the "connecting loops" and COOH-terminal strands form prominent radial projections which are the antigenic sites of the virion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hogle, J M -- Chow, M -- Filman, D J -- AI-20566/AI/NIAID NIH HHS/ -- AI-22346/AI/NIAID NIH HHS/ -- NS-07078/NS/NINDS NIH HHS/ -- R01 AI020566/AI/NIAID NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Sep 27;229(4720):1358-65.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2994218" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Antigens, Viral/immunology ; Capsid/physiology ; Chemical Phenomena ; Chemistry ; HeLa Cells/microbiology ; Mutation ; Poliovirus/physiology/*ultrastructure ; Protein Conformation ; Virus Replication ; X-Ray Diffraction
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 68
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    An omnifarious data bank for biology? (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-06-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Jun 21;228(4706):1412-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012300" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Information Systems ; *Models, Biological ; National Institutes of Health (U.S.) ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 69
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    HHS revises rules on animal research (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 May 17;228(4701):830.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001924" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Care Committees ; *Animal Experimentation ; *Animal Testing Alternatives ; Animals ; *Animals, Laboratory ; Behavioral Research ; Biomedical Research ; Federal Government ; *Government Regulation ; *Research ; United States ; United States Public Health Service
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 70
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    Getting health promotion into Medicare (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-03-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Mar 8;227(4691):1183.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3883486" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Health Promotion/*legislation & jurisprudence ; Medicare/*legislation & jurisprudence ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 71
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    Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-24
    Beschreibung: Experiments were conducted to test the hypothesis that tumor-derived transforming growth factor-alpha (TGF-alpha) is responsible for the increased bone resorption and hypercalcemia seen in some malignant diseases. Homogeneous synthetic TGF-alpha prepared by the solid-phase synthesis method stimulated bone resorption directly in vitro in a concentration-dependent manner. Incubation times of 72 hours or more were required to stimulate resorption, which is similar to the time course of bone resorption by epidermal growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ibbotson, K J -- Twardzik, D R -- D'Souza, S M -- Hargreaves, W R -- Todaro, G J -- Mundy, G R -- AM-28149/AM/NIADDK NIH HHS/ -- CA-29537/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 May 24;228(4702):1007-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3859011" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bone Resorption/*drug effects ; Bone and Bones/drug effects ; Dose-Response Relationship, Drug ; History, 20th Century ; Kinetics ; Molecular Weight ; Organ Culture Techniques ; Peptides/chemical synthesis/*pharmacology ; Rats ; Transforming Growth Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 72
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    Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-13
    Beschreibung: The pol gene of Rous sarcoma virus is positioned downstream of the gag gene in a different, briefly overlapping reading frame; nevertheless, the primary translation product of pol is a gag-pol fusion protein. Two mechanisms, ribosomal frameshifting and RNA splicing, have been considered to explain this phenomenon. The frameshifting model is supported by synthesis of both gag protein and gag-pol fusion protein in a cell-free mammalian translation system programmed by a single RNA species that was synthesized from cloned viral DNA with a bacteriophage RNA polymerase. Under these conditions, the ratio of the gag protein to the fusion protein (about 20 to 1) is similar to that previously observed in infected cells, the frameshifting is specific for the gag-pol junction, and it is unaffected by large deletions in gag. In addition, synthesis of the fusion protein is ten times less efficient in an Escherichia coli cell-free translation system and cannot be explained by transcriptional errors or in vitro modification of the RNA. Ribosomal frameshifting may affect production of other proteins in higher eukaryotes, including proteins encoded by several retroviruses and transposable elements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacks, T -- Varmus, H E -- New York, N.Y. -- Science. 1985 Dec 13;230(4731):1237-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2416054" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Avian Sarcoma Viruses/*genetics ; Base Sequence ; Cell-Free System ; *Gene Expression Regulation ; Gene Products, gag ; Molecular Weight ; *Protein Biosynthesis ; RNA, Messenger/genetics ; RNA, Viral/genetics ; RNA-Directed DNA Polymerase/*genetics ; Rabbits ; Retroviridae Proteins/genetics ; Ribosomes/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 73
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    Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-06-07
    Beschreibung: Human T-lymphotropic virus type III (HTLV-III) is thought to play an etiologic role in the development of the acquired immune deficiency syndrome (AIDS). In this study the serologic characterization of a new simian retrovirus that is related to HTLV-III is described. This new virus, here referred to as STLV-III, was isolated from sick macaques at the New England Regional Primate Research Center. Radioimmunoprecipitation analysis revealed STLV-III-specific proteins of 160, 120, 55, and 24 kilodaltons, all similar in size to the major gag and env proteins of HTLV-III. These antigens were recognized by representative macaque serum samples and human reference serum samples positive for HTLV-III antibodies. Monoclonal antibodies directed to p24, the major core protein of HTLV-III, also immunoprecipitated a 24-kilodalton species in lysates of cells infected with the macaque virus. This HTLV-III-related virus, which naturally infects a nonhuman primate species, may provide a useful model for the study of HTLV-III and the pathogenesis of AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kanki, P J -- McLane, M F -- King, N W Jr -- Letvin, N L -- Hunt, R D -- Sehgal, P -- Daniel, M D -- Desrosiers, R C -- Essex, M -- 5TRRR07000/RR/NCRR NIH HHS/ -- CA18216/CA/NCI NIH HHS/ -- CA37466/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Jun 7;228(4704):1199-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3873705" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*veterinary ; Animals ; Antigens, Viral/analysis ; Glycoproteins/immunology ; Lymphoma/microbiology ; Macaca/*microbiology ; Molecular Weight ; Monkey Diseases/microbiology ; Retroviridae/*immunology/isolation & purification ; T-Lymphocytes/*microbiology ; Viral Proteins/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 74
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    AIDS repository (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-07-05
    Beschreibung: In the article "Spotlight falls on science policy" (News and Comment, 10 May, p. 691) by Mark H. Crawford, the findings of a General Accounting Office report on the operating costs of the Continuous Electron Beam Accelerator Facility (CEBAF) were overstated. The report found that the Department of Energy's operating costs would rise by $80 million if both CEBAF and the Relativistic Heavy Ion Collider are constructed. CEBAF's operating cost is estimated to be $30 million. The report also found problems in accommodating the operating costs of the proposed Superconducting Super Collider in the department's budget.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaslow, R A -- New York, N.Y. -- Science. 1985 Jul 5;229(4708):8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012314" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Acquired Immunodeficiency Syndrome ; *Homosexuality ; Humans ; Male ; National Institutes of Health (U.S.) ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 75
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    Government policies and the cost of doing research (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-02-01
    Beschreibung: The changes in the political economy of science are the natural outcome of two trends: science itself has become a more capital-intensive activity at the same time that federal support for research programs has slowed its growth. The results of the accumulating shortfall in the capital base for university research--increased seeking of support from private industry, efforts to circumvent peer review and competitive allocation, and a falling-out between institutions and investigators over how to divide up available resources--threaten to unravel what has been an extraordinary way of doing science.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, D -- New York, N.Y. -- Science. 1985 Feb 1;227(4686):480-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966157" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Academies and Institutes ; Government ; National Institutes of Health (U.S.) ; Peer Review ; Politics ; *Research Support as Topic ; United States ; Universities
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 76
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    Dispute over access to Reye's study data (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):297-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996130" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aspirin/*adverse effects ; Centers for Disease Control and Prevention (U.S.) ; Child ; Federal Government ; Humans ; *Jurisprudence ; Research ; Reye Syndrome/*chemically induced ; *Technology, Pharmaceutical ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 77
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    Breast cancer consensus (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Sep 27;229(4720):1378.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3898364" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Breast Neoplasms/*drug therapy/pathology/therapy ; Clinical Trials as Topic ; Female ; Humans ; Lymphatic Metastasis ; Menopause ; Middle Aged ; National Institutes of Health (U.S.) ; Receptors, Estrogen/drug effects ; Tamoxifen/therapeutic use ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 78
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    Surgeons disagree on artificial heart (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Nov 15;230(4727):786-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3904000" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Heart Transplantation ; *Heart, Artificial ; Humans ; Patient Selection ; Resource Allocation ; *Risk Assessment ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 79
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    Is the war on cancer being won? (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-08-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Aug 9;229(4713):543-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023699" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; Neoplasms/diagnosis/mortality/*prevention & control ; Research ; Statistics as Topic ; Time Factors ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 80
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    Testing for trichinosis (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-02-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Feb 8;227(4687):621, 624.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3969551" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Enzyme-Linked Immunosorbent Assay ; Humans ; *Meat ; Swine ; Trichinella ; Trichinellosis/*prevention & control ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 81
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    Heart panel's conclusions questioned (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-01-04
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Jan 4;227(4682):40-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3880617" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cholesterol/*blood ; Cholesterol, Dietary/adverse effects ; Clinical Trials as Topic ; Coronary Disease/etiology/*prevention & control ; Diet ; Female ; Humans ; Male ; Middle Aged ; *National Institutes of Health (U.S.) ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 82
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    NIH budget and better health (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-06-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- New York, N.Y. -- Science. 1985 Jun 21;228(4706):1382.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3839316" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Health ; *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 83
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    Modest proposals for the granting system (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-07-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- New York, N.Y. -- Science. 1985 Jul 19;229(4710):231.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012319" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 84
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    Benefits, risks, vaccines, and the courts (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- New York, N.Y. -- Science. 1985 Mar 15;227(4692):1289.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975614" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; *Compensation and Redress ; Federal Government ; Humans ; Jurisprudence ; Legislation, Medical ; Risk Assessment ; United States ; *Vaccines/adverse effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 85
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    Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-06-07
    Beschreibung: Infection of human T cells by human T-lymphotropic virus, type I (HTLV-I), a retrovirus, is uniformly associated with the constitutive expression of large numbers of cellular receptors for interleukin-2 (IL-2). Comparison with normal T cells shows that neither IL-2 receptor gene organization nor IL-2 receptor messenger RNA processing are altered in the leukemic cells. However, mitogenic stimuli activate IL-2 receptor gene expression in normal T cells, whereas these stimuli paradoxically inhibit IL-2 receptor gene transcription in HTLV-I-infected leukemic T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kronke, M -- Leonard, W J -- Depper, J M -- Greene, W C -- New York, N.Y. -- Science. 1985 Jun 7;228(4704):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2988127" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Nucleus/physiology ; Cells, Cultured ; DNA/genetics ; Deltaretrovirus ; Humans ; Leukemia/*genetics ; Molecular Weight ; Poly A/genetics ; RNA, Messenger/genetics ; Receptors, Immunologic/*genetics ; Receptors, Interleukin-2 ; T-Lymphocytes/microbiology/*physiology ; Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 86
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    Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-06-07
    Beschreibung: The 55 codons upstream of the gene sequence encoding the hepatitis B surface antigen (HBsAg) are called the pre-S(2) region. It has been proposed that polypeptides of high molecular weight that contain the pre-S(2) region should be included in future hepatitis B virus (HBV) vaccines. The pre-S(2) region and the S gene product [25 kilodalton (kD)] together compose a polypeptide of high molecular weight (33 kD). As an initial attempt to determine the relevance of the 33-kD polypeptide to development of an HBV vaccine, the murine immune response to pre-S(2)-encoded determinants as compared to S-encoded determinants on the same polypeptide was examined. The results indicate (i) the pre-S(2) region is significantly more immunogenic than the S region of HBsAg, (ii) the 26 amino acid residues at the NH2-terminus of the 33-kD polypeptide represent a dominant antibody binding site on the pre-S(2) region, (iii) the immune response to the pre-S(2) region is regulated by H-2-linked genes distinct from those that regulate the response to the S region, and (iv) immunization of an S region nonresponder strain with HBV envelope particles that contain both the pre-S(2) and S regions can circumvent nonresponsiveness to the S region.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Milich, D R -- Thornton, G B -- Neurath, A R -- Kent, S B -- Michel, M L -- Tiollais, P -- Chisari, F V -- AI 00585/AI/NIAID NIH HHS/ -- AI 20001/AI/NIAID NIH HHS/ -- AI 20720/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 7;228(4704):1195-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2408336" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antibody Formation ; Antibody Specificity ; Epitopes ; Genes, MHC Class II ; Genes, Viral ; Hepatitis B Antibodies/immunology ; Hepatitis B Surface Antigens/genetics/*immunology ; Mice ; Molecular Weight ; Protein Precursors/genetics/immunology ; Viral Hepatitis Vaccines/*immunology ; Viral Proteins/genetics/immunology
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 87
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    Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-01-25
    Beschreibung: The expression of a previously unidentified gene product, encoded by the hepatitis B virus (HBV) genome, has been achieved with a recombinant SV40 expression vector. Antibodies against synthetic peptides representing defined regions of this protein were used to screen cells infected with recombinant virus as well as tissues naturally infected with HBV. A 24,000-dalton protein (p24) was detected in cells infected with recombinant virus and a 28,000-dalton protein (p28) was detected in tissues infected with HBV. The peptides or recombinant-derived protein were used as antigens to screen sera from individuals infected with HBV. Specific antibodies were detected predominantly in sera from patients with hepatocellular carcinoma. The presence of p28 in tissues infected with HBV and the appearance of specific antibodies in infectious sera establish the existence of an additional marker for HBV infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moriarty, A M -- Alexander, H -- Lerner, R A -- Thornton, G B -- New York, N.Y. -- Science. 1985 Jan 25;227(4685):429-33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2981434" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carcinoma, Hepatocellular/diagnosis/*immunology ; Cell Line ; Cloning, Molecular ; Enzyme-Linked Immunosorbent Assay ; Genetic Vectors ; Hepatitis B/diagnosis/*immunology ; Hepatitis B Antibodies/*analysis/immunology ; Hepatitis B Antigens/*analysis/immunology ; Humans ; Liver/*immunology ; Liver Neoplasms/diagnosis/*immunology ; Molecular Weight ; Peptides/immunology ; Simian virus 40/genetics ; Viral Proteins/immunology
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 88
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    Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-08-02
    Beschreibung: Crude fractions of urine from pregnant women are immunosuppressive in vitro. An 85-kilodalton immunosuppressive glycoprotein purified to homogeneity from such urine inhibited in vitro assays of human T-cell and monocyte activity at concentrations of 10(-9) to 10(-11) molar. This material was nontoxic and blocked early events required for normal T-cell proliferation in vitro. On the basis of its tissue source and its in vitro activity, the name "uromodulin" is proposed for this glycoprotein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muchmore, A V -- Decker, J M -- New York, N.Y. -- Science. 1985 Aug 2;229(4712):479-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2409603" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): B-Lymphocytes/drug effects ; Chromatography/methods ; Collodion ; Cytotoxicity, Immunologic/drug effects ; Electrophoresis, Polyacrylamide Gel ; Epitopes ; Female ; Hemolytic Plaque Technique ; Humans ; Immunosuppressive Agents/isolation & purification/*urine ; In Vitro Techniques ; Isoelectric Focusing ; Lymphocyte Activation/drug effects ; Molecular Weight ; *Mucoproteins ; Pregnancy ; Pregnancy Proteins/isolation & purification/pharmacology/*urine ; T-Lymphocytes/drug effects ; Uromodulin
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 89
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    A test of clathrin function in protein secretion and cell growth (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-11-29
    Beschreibung: Clathrin-coated membranes are intimately associated with a variety of protein transport processes in eukaryotic cells, yet no direct test of clathrin function has been possible. The data presented demonstrate that Saccharomyces cerevisiae does not require clathrin for either cell growth or protein secretion. Antiserum to the yeast clathrin heavy chain has been used to isolate a molecular clone of the heavy chain gene (CHC1) from a library of yeast DNA in lambda gt11. Clathrin-deficient mutant yeast have been obtained by replacing the single chromosomal CHC1 gene with a disrupted version of the cloned DNA. Cells harboring a nonfunctional chc1 allele produce no immunoreactive heavy chain polypeptide, and vesicles prepared from mutant cells are devoid of clathrin heavy and light chains. Although clathrin-deficient cells grow two to three times more slowly than normal, secretion of invertase occurs at a nearly normal rate. Therefore protein transport through the secretory pathway is not obligately coupled to the formation of clathrin-coated vesicles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Payne, G S -- Schekman, R -- New York, N.Y. -- Science. 1985 Nov 29;230(4729):1009-14.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2865811" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biological Transport ; *Cell Physiological Phenomena ; Clathrin/genetics/immunology/*physiology ; Coated Pits, Cell-Membrane/*physiology ; Endosomes/*physiology ; Eukaryotic Cells/*physiology ; Genes ; Genes, Fungal ; Genetic Engineering ; Glycoside Hydrolases/secretion ; Macromolecular Substances ; Molecular Weight ; Proteins/*secretion ; Saccharomyces cerevisiae/genetics ; beta-Fructofuranosidase
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 90
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    Thermosensitivity of a DNA recognition site: activity of a truncated nutL antiterminator of coliphage lambda (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-04-05
    Beschreibung: Antitermination is an important transcriptional control. In bacteriophage lambda, the presence of the nut antiterminators between the promoters and terminators results in relatively unhindered transcription when the lambda N gene product and necessary host factors are supplied. This antitermination system has been rendered thermosensitivity by modification of the nut site. A fragment of lambda DNA [74 base pairs (bp) in length]that contained the 17-bp nutL core sequence, but lacked the 8-bp boxA sequence, was cloned in a pp-N-tL1-galK plasmid between the pp promoter and gene N. This fragment mediated antitermination of transcription at 30 degrees C, as measured by assaying galK gene expression in Escherichia coli. At 42 degrees C, however, antitermination at the lambda tL1 terminator was abolished. Antitermination at 42 degrees C was restored by replacing the 74-bp nutL fragment with longer sequences containing both nutL and boxA or by cloning a synthetic boxA sequence ahead of the 74-bp nutL fragment. Thus, efficient antitermination required both boxA and the 17-bp nutL core, with the latter becoming conditionally defective when the boxA sequence was deleted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peltz, S W -- Brown, A L -- Hasan, N -- Podhajska, A J -- Szybalski, W -- 5-P30-CA-07175/CA/NCI NIH HHS/ -- 5-PO1-CA-23076/CA/NCI NIH HHS/ -- CA-09135/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Apr 5;228(4695):91-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3156406" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bacteriophage lambda/*genetics ; DNA, Viral/*genetics/physiology ; Escherichia coli/genetics ; Hot Temperature ; Mutation ; Plasmids ; Promoter Regions, Genetic ; Terminator Regions, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 91
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    Retinal S antigen identified as the 48K protein regulating light-dependent phosphodiesterase in rods (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-17
    Beschreibung: Retinal S antigen chromatographically purified from whole retina, induces experimental autoimmune uveoretinitis in laboratory animals. The 48K protein, a soluble protein found in rod outer segments, is purified through its specific binding to photoexcited rhodopsin and is involved in the quenching of light-induced guanosine 3',5'-monophosphate-phosphodiesterase activity. Biochemical, immunological, functional, and pathological tests showed that retinal S antigen and the 48K protein are identical.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pfister, C -- Chabre, M -- Plouet, J -- Tuyen, V V -- De Kozak, Y -- Faure, J P -- Kuhn, H -- New York, N.Y. -- Science. 1985 May 17;228(4701):891-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2988124" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 3',5'-Cyclic-GMP Phosphodiesterases/*metabolism ; Animals ; *Antigens/isolation & purification ; Arrestin ; Autoimmune Diseases/etiology ; Cattle ; Eye Proteins/immunology/isolation & purification/pharmacology ; Light ; Molecular Weight ; Photoreceptor Cells/*enzymology ; Rats ; Retina/analysis/*immunology ; Rod Cell Outer Segment/analysis/immunology ; Uveitis/etiology
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 92
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    Isolation and propagation of a human enteric coronavirus (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-06
    Beschreibung: Coronavirus-like particles were found by electron microscopy in stools from infants with necrotizing enterocolitis. Stool samples from these infants as well as control specimens were passaged in cultures of human fetal intestinal organs. Two samples yielded virus-like particles and these have now been passaged 14 times (HEC 14). Gradient-purified HEC 14 strains had typical coronavirus morphology on electron microscopy and contained five major proteins with molecular sizes ranging from 190 to 23 kilodaltons. Infants with necrotizing enterocolitis developed specific antibody to the viral antigens between the acute and convalescent stages of the disease, as shown by examining serum specimens by single radial hemolysis, immunoenzymatic assay, and Western immunoblotting. No cross-reactivity was shown with other coronavirus strains tested, or with the newly isolated viruses of the Breda-Berne group, responsible for calf or horse diarrhea.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Resta, S -- Luby, J P -- Rosenfeld, C R -- Siegel, J D -- New York, N.Y. -- Science. 1985 Sep 6;229(4717):978-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992091" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigens, Viral/analysis ; Coronaviridae/immunology/*isolation & purification ; Coronaviridae Infections/*microbiology ; Cross Infection ; Disease Outbreaks ; Enterocolitis, Pseudomembranous/*microbiology ; Feces/microbiology ; Humans ; Infant ; Microscopy, Electron ; Molecular Weight ; Viral Proteins/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 93
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    GAO find errors in A-bomb test data (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1985 Dec 20;230(4732):1361.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071056" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; Japan ; *Military Personnel ; *Nuclear Warfare ; Radiation Injuries/*etiology ; United States
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 94
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    The stability of DNA in human cerebellar neurons (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-24
    Beschreibung: Human tissues have carbon-isotope ratios (13C/12C) that reflect dietary ratios. This observation has been used to determine the extent of metabolic turnover of DNA in cells of the adult human cerebellum (90 percent of which are neuronal). If adult human neuronal DNA were metabolically stable, its 13C/12C would reflect that in the maternal diet during fetal development as nearly all neurons are formed during maturation of the fetal brain and do not undergo cell division thereafter. The 13C/12C ratios in the food chains and body tissues of Europeans differ from corresponding American ratios by about 50 parts per million on the average. Therefore, turnover was studied by comparing 13C/12C ratios in cerebellar DNA of American-born Americans, European-born Americans, and European-born Europeans. The 13C/12C ratios in cerebellar DNA from European-born Americans were closer to 13C/12C ratios in cerebellar DNA from European-born Europeans than from American-born Americans, indicating that there was little or no turnover of neuronal DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slatkin, D N -- Friedman, L -- Irsa, A P -- Micca, P L -- NS 17822-01 RNM/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 May 24;228(4702):1002-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001927" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; Aging ; Carbon ; Carbon Isotopes ; Cerebellum/cytology/*metabolism ; DNA/*metabolism ; Europe/ethnology ; Female ; Humans ; Male ; Middle Aged ; Neurons/*metabolism ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 95
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    Vaccination against Schistosoma mansoni with purified surface antigens (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-02-01
    Beschreibung: Two surface antigens were isolated from young or adult schistosomes by affinity chromatography with monoclonal antibodies. Vaccination with an antigen having a molecular weight of 155,000 gave partial protection against challenge in some batches of mice and in a group of cynomolgus monkeys. Vaccination with an antigen having a molecular weight of 53,000 gave similar levels of protection in mice. The results demonstrate that protection can be obtained with single antigens, but the precise requirements for reproducible vaccination are as yet unknown.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, M A -- Clegg, J A -- New York, N.Y. -- Science. 1985 Feb 1;227(4686):535-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966161" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal ; Antigens, Helminth/*immunology/isolation & purification ; Antigens, Surface/*immunology/isolation & purification ; Chromatography, Affinity ; Immunoglobulin E/biosynthesis ; Immunoglobulin G/biosynthesis ; Immunoglobulin M/biosynthesis ; Macaca fascicularis ; Macrophage Activation ; Mice ; Molecular Weight ; Schistosoma mansoni/*immunology ; Schistosomiasis/immunology/*prevention & control ; *Vaccination ; Vaccines
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 96
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    A model for the tertiary structure of p21, the product of the ras oncogene (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-10-04
    Beschreibung: A model was developed for the structure of p21, the protein with a molecular weight of 21,000 that is produced by the ras genes. This model predicts that p21 consists of a central core of beta-sheet structure, connected by loops and alpha helices. Four of these loops comprise the guanine nucleotide binding site. The phosphoryl binding region is made up of amino acid sequences from 10 to 16 and from 57 to 63 of p21. The latter sequence may contain a site for magnesium binding. Amino acids defining guanine specificity are Asn-116 and Asp-119, and sequences around amino acid 145 may contribute to guanine binding. The model makes it possible to visualize how oncogenic mutations of p21 affect interaction with guanine nucleotides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCormick, F -- Clark, B F -- la Cour, T F -- Kjeldgaard, M -- Norskov-Lauritsen, L -- Nyborg, J -- New York, N.Y. -- Science. 1985 Oct 4;230(4721):78-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3898366" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acids/analysis ; Animals ; *Aspartate Carbamoyltransferase ; Base Sequence ; Binding Sites ; *Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) ; Cattle ; *Dihydroorotase ; Escherichia coli ; Guanine Nucleotides/metabolism ; Humans ; Macromolecular Substances ; Magnesium/metabolism ; Membrane Proteins/analysis ; Models, Chemical ; *Multienzyme Complexes ; Mutation ; *Oncogenes ; Peptide Elongation Factor Tu ; Peptide Elongation Factors/analysis ; Protein Conformation ; Proteins/*analysis ; RNA, Transfer, Amino Acyl/metabolism ; Saccharomyces cerevisiae ; Transducin
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 97
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    NIH gaining in grants battle (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-04-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Apr 5;228(4695):35.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975632" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *National Institutes of Health (U.S.) ; Research Support as Topic/*legislation & jurisprudence ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 98
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    New curriculum at Harvard Medical School (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-01-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Jan 11;227(4683):153.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966150" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Curriculum ; *Education, Medical ; Physician-Patient Relations ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 99
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    Colocalization of band 3 with ankyrin and spectrin at the basal membrane of intercalated cells in the rat kidney (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-12-13
    Beschreibung: An immunoreactive form of the anion channel protein of erythrocytes, band 3, has been identified in the rat kidney. It is found in the intercalated cells of the distal tubule and collecting ducts. Immunostaining specific for band 3 is confined to the basolateral plasma membrane of these cells, where this protein probably mediates the transport of bicarbonate across the tubular wall. Double-immunolabeling studies demonstrate that band 3 is colocalized with immunoreactive forms of ankyrin and spectrin along the basolateral plasma membrane. The polarized distribution of band 3 may be the result of the association of its cytoplasmic domain with ankyrin, which in turn links band 3 to spectrin and the cytoskeleton. These observations help to explain how the collecting ducts of the kidney can direct the transport of bicarbonate ions, thus maintaining the acid-base balance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Drenckhahn, D -- Schluter, K -- Allen, D P -- Bennett, V -- K04 AM00926/AM/NIADDK NIH HHS/ -- R01 AM29808/AM/NIADDK NIH HHS/ -- R01 GM33996/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 Dec 13;230(4731):1287-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2933809" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anion Exchange Protein 1, Erythrocyte/*metabolism ; Ankyrins ; Bicarbonates/*metabolism ; Cell Membrane/metabolism ; Fluorescent Antibody Technique ; Immunosorbent Techniques ; Kidney/metabolism/*ultrastructure ; Kidney Tubules, Collecting/metabolism/ultrastructure ; Kidney Tubules, Distal/metabolism/ultrastructure ; Macromolecular Substances ; Membrane Proteins/*metabolism ; Molecular Weight ; Rats ; Spectrin/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 100
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    Gonadotropin-releasing hormone binding sites in human breast carcinoma (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-06
    Beschreibung: Gonadotropin-releasing hormone analogs can cause regression of hormone-dependent breast carcinomas. These effects are thought to be mediated through the inhibition of gonadotropic and steroid hormones. These analogs may also act directly on the tumor because they are effective in treating breast cancer in some postmenopausal women. The presence of specific binding sites for gonadotropin-releasing hormone was demonstrated in human breast carcinomas by means of a novel approach of ligand immunoblotting. The results indicate a possible mechanism by which the peptide has direct effects on this tissue. These binding proteins were not detectable in non-neoplastic breast tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eidne, K A -- Flanagan, C A -- Millar, R P -- New York, N.Y. -- Science. 1985 Sep 6;229(4717):989-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992093" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Breast Neoplasms/*metabolism ; Female ; Gonadotropin-Releasing Hormone/*metabolism ; Humans ; Membrane Proteins/metabolism ; Menopause ; Middle Aged ; Molecular Weight ; Receptors, Cell Surface/*metabolism ; Receptors, LHRH
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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