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  • bioavailability  (28)
  • taxonomy  (28)
  • Springer  (56)
  • American Chemical Society
  • American Institute of Physics (AIP)
  • Institute of Physics
  • Oxford University Press
  • 2005-2009
  • 1980-1984  (56)
  • 1984  (56)
Collection
Keywords
Publisher
  • Springer  (56)
  • American Chemical Society
  • American Institute of Physics (AIP)
  • Institute of Physics
  • Oxford University Press
Years
  • 2005-2009
  • 1980-1984  (56)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacodynamics and pharmacokinetics of xipamide in patients with normal and impaired kidney function (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 513-520 
    Details
    ISSN: 1432-1041
    Keywords: xipamide ; electrolyte excretion ; bioavailability ; elimination ; extrarenal clearance ; chronic renal failure ; furosemide ; hydrochlorothiazide ; amiloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of a single oral dose of 40 mg xipamide on urinary excretion of Na+, K+, Cl−, Ca2+ and Mg2+ in healthy subjects and in patients with varying degrees of renal impairment was compared with various conventional diuretics. Xipamide caused marked excretion of Na+ and Cl−, whereas the diuretic produced only moderate kaliuresis; urinary excretion of Ca2+ was increased in proportion to Na+, like the loop diuretics. Xipamide affected electrolyte excretion even in patients with a creatinine clearance below 30 ml/min, as do the loop diuretics, too. Therefore, the pharmacodynamic characteristics of xipamide are more like those of a loop diuretic than of a thiazide. Xipamide was good bioavailable, its t1/2β was 7 h and urinary recovery of the undegraded drug was 40% of the given dose. In renal insufficiency, t1/2β increased from 7 to only 9 h, yielding a moderate increase in the AUC. Urinary recovery of the drug was reduced in proportion to the reduction in the creatinine clearance of the patient. Therefore, significant extrarenal elimination of the diuretic must be postulated, which suffices to prevent significant drug accumulation in renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542150
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  • 2
    Electronic Resource
    Electronic Resource
    Bioavailability and pharmacokinetics of phenytoin during pregnancy (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 105-110 
    Details
    ISSN: 1432-1041
    Keywords: phenytoin ; epileptic women ; pharmacokinetics ; bioavailability ; pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug. Plasma phenytoin concentration — time data were analysed by three different pharmacokinetic techniques. However assessed, the mean oral bioavailability of the drug proved to be about 90% of the intravenous bioavailability. This finding makes it unlikely that impaired bioavailability accounts for the increase in oral phenytoin dosage necessary in pregnancy to maintain plasma phenytoin concentrations at pre-pregnancy values. Phenytoin clearance in the pregnant subjects was approximately double the published values for phenytoin clearance in nonpregnant persons. This suggests that increased (metabolic) clearance accounts for the increased phenytoin dosage requirement of pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02395215
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  • 3
    Electronic Resource
    Electronic Resource
    Implications of intraindividual variability in bioavailability studies of furosemide (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 595-602 
    Details
    ISSN: 1432-1041
    Keywords: furosemide ; bioavailability ; generic tablet formulations ; intrasubject variability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Intrasubject variation in bioavailability (rate and extent) and disposition of furosemide 40 mg was investigated using a repeated, randomized, double-blind cross-over study in 8 healthy subjects. Two generic tablet formulations (Lasix and Furix) and intravenous furosemide were compared on 6 separate days. Extensive intrasubject variability after oral administration was observed in AUC, mean absorption time (MAT) and urinary excretion. The variability (error variance) within the dosage forms was as large as that between the two generics. These variations most probably depended on the absorption process, since the repeated i.v. doses showed only marginal intrasubject variability. Absolute bioavailability was 56% for Lasix and 55% for Furix (AUC). The range was 20 to 84% between individuals and the maximal range within one individual was 20 to 61%. Confidence interval and Bayesian analysis showed a high probability of non-equivalence not only between but also within the generics when the separate cross-over experiments were analyzed (8 observations). When extending the analysis to 16 observations, bioequivalence was demonstrated for the two generic tablets. Rate of absorption, quantified as MAT, was 128 min for Lasix and 98 min for Furix (16 observations). Since MAT was significantly longer (p〈0.001) than the mean residence time after the i.v. dose (57 min), absorption was evidently the rate-limiting step in the overall kinetics of oral furosemide. Intraindividual variation in absorption is a confounding factor in bioavailability studies of furosemide using limited numbers of subjects. This is important to consider when designing and evaluating bioavailability studies for drugs showing these variations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00556898
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  • 4
    Electronic Resource
    Electronic Resource
    Food does not effect in bioavailability of theophylline from Theolin Retard® (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 405-407 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; drug absorption ; bioavailability ; food intake ; sustained-release preparations ; Theolin Retard
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The absorption of theophylline from a sustained release tablet preparation (Theolin® Retard 300 mg) was studied in 10 subjects both when fasting and immediately after a standardized breakfast. Intravenous aminophylline was used as the reference material. Food did not influence the absorption from Theolin Retard. The bioavailability was complete (93% after 30 h) both with and without food, and no difference was found in the time to peak of the plasma concentration curve (7 h), or the mean residence time (14 h). The absorption characteristics, with predominantly zero order kinetics, did not change with concomitant intake of breakfast.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548776
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of food on pharmacokinetics of chlorambucil and its main metabolite, phenylacetic acid mustard (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 111-114 
    Details
    ISSN: 1432-1041
    Keywords: chlorambucil ; chronic lymphocytic leukaemia ; phenylacetic acid mustard ; food intake ; pharmacokinetics ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of food intake on the pharmacokinetics of chlorambucil (C) and its cytotoxic metabolite, phenylacetic acid mustard (PAM), has been studied in man after oral doses of chlorambucil. The administration of chlorambucil with food resulted in slower absorption than when fasting. However, the area under the plasma concentration-time curve (AUC) was unaffected. The mean ratio AUCPAM/AUCC was 2.8 (range 1.4–7.1) under fasting and 3.3 (range 1.3–7.4) under nonfasting conditions. The metabolite very probably plays an important role in the cytotoxic effects observed after administration of C, since calculations show that a major fraction of the metabolite is eliminated by alkylation reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553164
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  • 6
    Electronic Resource
    Electronic Resource
    Studies of the bioavailability of nitroglycerin from a transdermal therapeutic system (Nitroderm TTS) (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 7-12 
    Details
    ISSN: 1432-1041
    Keywords: nitroglycerin ; plasma concentration ; transdermal administration ; bioavailability ; pharmacodynamics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 6 healthy volunteers, intravenous infusions of nitroglycerin 4.8 and 10.6 µg/min yielded mean steady-state plasma concentrations of 0.5±0.02 and 0.82±0.04 ng/ml as determined by a gas chromatographic/mass spectrometric method. The plasma concentrations reached in the same subjects 17 h after application of Nitroderm TTS 5 and 10 with in vivo release rates of 3.7 and 5.7 µg/min were 0.28±0.01 and 0.37±0.01 ng/ml, respectively. Thus, 75% of the quantity of nitroglycerin released by the systems passed into the circulation. The inter-individual and intra-individual variations in plasma concentrations were similar for both modes of administration. The nitroglycerin-induced morphological changes in the fingerpulse wave were clearly dose-dependent, but it seems that this pharmacodynamic parameter is determined less by the plasma concentration than by the nitroglycerin content of the vascular wall.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02395198
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  • 7
    Electronic Resource
    Electronic Resource
    Steady state bioavailability of a new oral formulation of Hydergine® in geriatric patients (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 133-135 
    Details
    ISSN: 1432-1041
    Keywords: co-dergocrine mesylate ; geriatric patients ; hydergine ; bioavailability ; steady state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The relative bioavailability of the newly developed formulation of co-dergocrine mesylate (Hydergine spezial, 1×4 mg) was determined in elderly patients under steady state conditions, with conventional Hydergine forte tablets (2×2 mg) as a reference. Both formulations were given once a day for 8 days in a randomised cross-over design. The areas under the curve showed that the bioavailability of the new tablet was about 30% higher (28±6.3%) than that of Hydergine forte. The peak plasma concentration was reached 3±0.9 h after administration. Because of its greater relative bioavailability higher plasma levels were found 2–24 hours after the Hydergine spezial formulation than after Hydergine forte tablets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00546722
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  • 8
    Electronic Resource
    Electronic Resource
    Bioequivalence studies in humans of indomethacin capsules marketed in India (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 261-264 
    Details
    ISSN: 1432-1041
    Keywords: indomethacin capsules ; bioequivalence ; volunteers ; pharmacokinetics ; statistical significance ; bioavailability ; comparative bioequivalence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Two, separate 6×6 Latin square cross-over bioequivalence studies were performed in adult male volunteers using 10 different indomethacin capsule preparations marketed in India together with the pure drug powder as the standard. The products were evaluated with respect to plasma level at various times up to 8 h following administration of a 50 mg (2 × 25 mg) dose. Plasma samples were analysed by a fluorimetric method. Various pharmacokinetic parameters were calculated according to a two compartment model. Statistical evaluation of the data employed analysis of variance for a cross-over design (ANOVA) and Duncan's multiple range test to ascertain the significance of differences between the products. Of the 10 products studied, two were found to be bioinequivalent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630296
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  • 9
    Electronic Resource
    Electronic Resource
    Elucidation of the structure and receptor binding studies of the major primary, metabolite of dihydroergotamine in man (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 463-470 
    Details
    ISSN: 1432-1041
    Keywords: dihydroergotamine ; 8′-hydroxy-dihydroergotamine ; plasma metabolites ; bioavailability ; receptor affinity ; healthy volunteers ; liver microsomal incubates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma concentrations and urinary excretion of dihydroergotamine and its metabolites have been measured after a single oral administration of 3 mg tritium-labelled drug to 6 male volunteers. The plasma level of non-volatile radioactivity declined biphasically with α- and β-phase half-lives of 2.1 h and 32.3 h, respectively. The peak plasma concentration was reached within 3.2h. Urinary excretion of total non-volatile radioactivity was low, amounting to 1.0% of the dose. The parent drug and four metabolites could be quantitated in urine and plasma samples. Metabolite 4 (8′-hydroxy-dihydroergotamine) was isolated from incubates of rat and monkey liver microsomal preparations. In human liver microsomal incubates, metabolite 4 was shown to be the primary metabolite of dihydroergotamine. In receptor binding studies performed with mammalian brain preparations, metabolite 4 had IC50-values at 6 monoaminergic binding sites similar to those of dihydroergotamine. Thus, it appears that the active principle consists at least of dihydroergotamine and its 8′-hydroxy derivative. As the concentration of metabolite 4 exceeded 5–7 times that of dihydroergotamine in urine and plasma, the bioavailability of dihydroergotamine should be reevaluated, taking into account the plasma concentrations of the parent drug and of its acitve metabolite, 8′-hydroxydihydroergotamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542142
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  • 10
    Electronic Resource
    Electronic Resource
    Bioavailability of amiodarone (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 533-534 
    Details
    ISSN: 1432-1041
    Keywords: amiodarone ; bioavailability ; clearance estimation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542153
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  • 11
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of nadolol in healthy subjects (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 125-127 
    Details
    ISSN: 1432-1041
    Keywords: nadolol ; pharmacokinetics ; plasma levels ; urinary excretion ; bioavailability ; circadian rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 7 healthy subjects (3 males and 4 females), the kinetics of nadolol was investigated after oral doses of 60 and 120 mg. The t1/2 was 14.0±1.8 h. The peak plasma level was doubled on doubling the dose (from 69±15 to 132±27 ng/ml, respectively) and the urinary excretion (13.5%) rose similarly. The half-life of elimination was longer at night than in the day, probably because of the slower nocturnal flow of urine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00546720
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  • 12
    Electronic Resource
    Electronic Resource
    The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: Age related differences as compared to adults (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 183-189 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; cystic fibrosis ; bioavailability ; renal clearance ; renal function differences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and metabolism of cimetidine were studied in five cystic fibrosis patients (mean age 12.6 years) after oral and intravenous administration. As compared to healthy adult volunteers, cystic fibrosis children had an elevated cimetidine total body clearance (474 vs 300 ml/min/m2) as well as renal clearance (293 vs 232 ml/min/m2) whether normalized for body weight or surface area differences. Cimetidine elimination was elevated in juvenile cystic fibrosis patients as compared to adult volunteers, however, it did not differ significantly from that previously seen in age matched children. There were no appreciable differences in cimetidine metabolism after either route of administration. Differences between adults and cystic fibrosis children were attributed to developmental and age related differences between the two groups. The recommended pediatric dose of 15 to 20 mg/kg, although four-fold greater than that used in adults, produces serum concentrations similar to those seen in adults, and is adequate for most juvenile cystic fibrosis patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630284
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  • 13
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of furosemide in man after intravenous and oral administration. Application of moment analysis (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 197-207 
    Details
    ISSN: 1432-1041
    Keywords: furosemide ; bioavailability ; pharmacokinetics ; oral administration ; i.v. administration ; drug absorption ; moment analysis ; food effect ; dissolution effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Furosemide 40 mg was administered to 8 healthy subjects as an i.v. bolus dose, as 1 tablet in the fasting state, and as 1 tablet and a solution after food intake. The i.v. data gave a total body clearance of 162±10.8 ml/min and a renal clearance of 117±11.3 ml/min; the volume of distribution at steady state was 8.3±0.61. Oral administration gave a bioavailability of the tablet (fasting) of 51%. Food intake slightly reduced the bioavailability, but not to a significant extent. There was no significant difference in availability between the tablet and the solution. Moment analysis gave a mean residence time after the i.v. dose, MRTi.v., of 51±1.5 min. The mean absorption times (MAT) for all oral doses were significantly longer than the MRTi.v., indicating absorption rate-limited kinetics of furosemide. On average, food delayed the absorption by 60 min. The MAT for the tablet in the postprandial state was significantly longer than for the solution, indicating dissolution rate-limited absorption of the tablet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630286
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  • 14
    Electronic Resource
    Electronic Resource
    Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 271-273 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; prednisolone ; aluminium phosphate ; antacids ; bioavailability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten fasting subjects received 200 mg cimetidine orally either with water or 11 g aluminium phosphate mixture in a randomized, single dose, two-way cross-over study. Blood samples were taken for 12 h and urine was collected for 24 h. Cimetidine in plasma and urine was analysed by HPLC. There were no significant differences between the treatments with respect to peak plasma concentration, time to peak plasma concentration, area under the plasma concentration-time curve, and urinary excretion. In 12 healthy subjects the absorption of prednisolone was investigated when given alone and together with 11 g aluminium phosphate. Blood samples were taken over 16 h and prednisolone in plasma was analysed by HPLC. There were no significant differences in the values of area under curve (AUC), Cmax and tmax. The results indicate that aluminium phosphate does not reduce the bioavailability of cimetidine and prednisolone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630299
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  • 15
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of cimetidine in advanced cirrhosis (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 347-355 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; cirrhosis ; pharmacokinetics ; bioavailability ; clearance reduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of impaired liver function on the pharmacokinetics of cimetidine was studied in 8 patients with advanced cirrhosis given single doses of 100 mg i.v. and 400 mg p.o. on separate days. Compared to a control group of 10 healthy volunteers, the total renal and nonrenal clearance was significantly reduced in the cirrhotic patients; (total plasma clearance mean ± SD) 356±181 vs 789±262 ml/min (p〈0.01); renal clearance (Clr) 296±100 vs 588±181 ml/min (p〈0.01) and nonrenal clearance (Clnr) 97±111 vs 205±89 ml/min (p〈0.05). Compared to published results for age-matched ulcer patients, both total and nonrenal clearance were lower whereas renal clearance was within the reported normal range. A significant reduction in volume of distribution (Vdβ) was found, from 2.1±0.1 l/kg in controls to 1.0±0.4l/kg, and in the patient group there was a significant correlation between Vdβ and total plasma clearance (r=0.72, p〈0.05). Volume of distribution in steady state (Vdss) did not differ from published results in age-matched controls. No significant change in half-life was found. Bioavailability, estimated by AUC-measurement, showed considerable patient variability (21–143%), with a mean of 70±39%. This was lower than in the controls. In contrast, measurement of urinary excretion showed higher bioavailability in the patients (66±23 vs 51±8%). No correlation was found between any of the kinetic parameters and the clinical and laboratory data. It is suggested that patients with advanced cirrhosis should be closely observed when given cimetidine, and a reduction in dose should be concidered if side effects are to be avoided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548766
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  • 16
    Electronic Resource
    Electronic Resource
    Bioavailability and pharmacokinetics of phenytoin during pregnancy (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 105-110 
    Details
    ISSN: 1432-1041
    Keywords: phenytoin ; epileptic women ; pharmacokinetics ; bioavailability ; pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug. Plasma phenytoin concentration — time data were analysed by three different pharmacokinetic techniques. However assessed, the mean oral bioavailability of the drug proved to be about 90% of the intravenous bioavailability. This finding makes it unlikely that impaired bioavailability accounts for the increase in oral phenytoin dosage necessary in pregnancy to maintain plasma phenytoin concentrations at pre-pregnancy values. Phenytoin clearance in the pregnant subjects was approximately double the published values for phenytoin clearance in nonpregnant persons. This suggests that increased (metabolic) clearance accounts for the increased phenytoin dosage requirement of pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553163
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  • 17
    Electronic Resource
    Electronic Resource
    Effect of food on pharmacokinetics of chlorambucil and its main metabolite, phenylacetic acid mustard (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 111-114 
    Details
    ISSN: 1432-1041
    Keywords: chlorambucil ; chronic lymphocytic leukaemia ; phenylacetic acid mustard ; food intake ; pharmacokinetics ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of food intake on the pharmacokinetics of chlorambucil (C) and its cytotoxic metabolite, phenylacetic acid mustard (PAM), has been studied in man after oral doses of chlorambucil. The administration of chlorambucil with food resulted in slower absorption than when fasting. However, the area under the plasma concentration-time curve (AUC) was unaffected. The mean ratio AUCPAM/AUCC was 2.8 (range 1.4–7.1) under fasting and 3.3 (range 1.3–7.4) under nonfasting conditions. The metabolite very probably plays an important role in the cytotoxic effects observed after administration of C, since calculations show that a major fraction of the metabolite is eliminated by alkylation reactions.
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    URL: http://dx.doi.org/10.1007/BF02395216
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  • 18
    Electronic Resource
    Electronic Resource
    Studies of the bioavailability of nitroglycerin from a transdermal therapeutic system (Nitroderm TTS) (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 7-12 
    Details
    ISSN: 1432-1041
    Keywords: nitroglycerin ; plasma concentration ; transdermal administration ; bioavailability ; pharmacodynamics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 6 healthy volunteers, intravenous infusions of nitroglycerin 4.8 and 10.6 µg/min yielded mean steady-state plasma concentrations of 0.5±0.02 and 0.82±0.04 ng/ml as determined by a gas chromatographic/mass spectrometric method. The plasma concentrations reached in the same subjects 17 h after application of Nitroderm TTS 5 and 10 with in vivo release rates of 3.7 and 5.7 µg/min were 0.28±0.01 and 0.37±0.01 ng/ml, respectively. Thus, 75% of the quantity of nitroglycerin released by the systems passed into the circulation. The inter-individual and intra-individual variations in plasma concentrations were similar for both modes of administration. The nitroglycerin-induced morphological changes in the fingerpulse wave were clearly dose-dependent, but it seems that this pharmacodynamic parameter is determined less by the plasma concentration than by the nitroglycerin content of the vascular wall.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553146
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  • 19
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of oral and rectal flurbiprofen in children (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 367-369 
    Details
    ISSN: 1432-1041
    Keywords: flurbiprofen ; syrup ; suppository ; kinetics ; children ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight subjects, aged 6–12 years and weighing 18.8–36.7 kg, received single doses of flurbiprofen 50 or 75 mg (corresponding to 1.4–2.7 mg/kg) as syrup and suppository in a Latin square design. Half-life (2.7–3.2 h), elimination constant (0.22–0.26 h−1), area under the plasma level curve (72.4–77.3 µg·h·ml−1) and time to reach the concentration peak (1–0.75 h) were similar after the syrup and suppository. Flurbiprofen showed equivalent bioavailability after oral and rectal administration and the same pharmacokinetic profile was confirmed in children as observed in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542178
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  • 20
    Electronic Resource
    Electronic Resource
    Cimetidine bioavailability and variable renal clearance (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 623-624 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; bioavailability ; renal clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00556904
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  • 21
    Electronic Resource
    Electronic Resource
    Bioavailability of cyclophosphamide from oral formulations (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 269-270 
    Details
    ISSN: 1432-1041
    Keywords: cyclophosphamide ; cytostatic drug ; cancer therapy ; female breast cancer ; bioavailability ; rapid release formulations ; gastric juice resistant formulation ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Cyclophosphamide (CP) is an alkylating cytostatic compound, which is activated to its cytotoxic form in the liver [1]. Since the therapeutic range of CP in the treatment of human tumours, is small like other cytostatics, a constant high bioavailability is essential for its oral administration. Although CP has become one of the most widely used cytostatics [2], there do not appear to have been any bioavailability investigations providing the necessary information. The development of a very sensitive gas chromatographic analytical method has now permited investigation of the pharmacokinetics of oral CP in conventional clinical doses [3, 4, 5, 6].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630298
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  • 22
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and bioavailability of digitoxin by a specific assay (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 85-89 
    Details
    ISSN: 1432-1041
    Keywords: digitoxin ; radioimmunoassay ; pharmacokinetics ; bioavailability ; digitoxin metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and bioavailability of digitoxin were examined in six normal human subjects using an assay that separates digitoxin from its metabolites. After intravenous administration, the mean systemic clearance was 2.44 ml/min; the volume of distribution was 0.47 l/kg; and the elimination half-life was 6.5 days. After oral administration, the elimination half-life was 5.8 days. The bioavailability was 81.5% using the specific assay. Using a non-specific, direct serum digitoxin radioimmunoassay the bioavailability was 98.0%. Assay of aqueous fractions from extracted serum samples indicated higher levels of water-soluble metabolites following oral compared to intravenous digitoxin administration. These findings suggest that previously reported values for digitoxin bioavailability using non-specific methods may be falsely elevated due to the presence of digitoxin metabolites in serum.
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    Pharmacokinetics and bioavailability of digitoxin by a specific assay (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 85-89 
    Details
    ISSN: 1432-1041
    Keywords: digitoxin ; radioimmunoassay ; pharmacokinetics ; bioavailability ; digitoxin metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and bioavailability of digitoxin were examined in six normal human subjects using an assay that separates digitoxin from its metabolites. After intravenous administration, the mean systemic clearance was 2.44 ml/min; the volume of distribution was 0.47 l/kg; and the elimination half-life was 6.5 days. After oral administration, the elimination half-life was 5.8 days. The bioavailability was 81.5% using the specific assay. Using a non-specific, direct serum digitoxin radioimmunoassay the bioavailability was 98.0%. Assay of aqueous fractions from extracted serum samples indicated higher levels of water-soluble metabolites following oral compared to intravenous digitoxin administration. These findings suggest that previously reported values for digitoxin bioavailability using non-specific methods may be falsely elevated due to the presence of digitoxin metabolites in serum.
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    The delimitation and taxonomic position of the tropical African generaLeptactina andDictyandra (Rubiaceae) (1984)
    Springer
    Plant systematics and evolution 145 (1984), S. 105-118 
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    ISSN: 1615-6110
    Keywords: Rubiaceae ; Coffeeae ; Gardenieae ; Pavetteae ; Dictyandra ; Leptactina ; Tarenna ; Pavetta ; Dictyandra congolana sp. nova ; taxonomy ; morphology ; seed-coat ; palynology ; Flora of tropical Africa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The closely related African generaDictyandra andLeptactina are redelimited. The two genera are distinguished by long tubular corolla-tubes with included anthers (Leptactina) vs. much shorter tubes with exserted anthers (Dictyandra), rather than—as previously thought—presence or absence of multilocellate anthers. The discovery of a new species (Dictyandra congolana from the Congo and W-Zaire) confirms this. It can be concluded, especially from comparative morphological studies of fruits and seeds, thatDictyandra andLeptactina are related toPavetta, Tarenna, Ixora, etc., i.e. the group of genera in theCoffeeae s.l. with terminal inflorescences. It is proposed that the tribePavetteae be revived to accomodate those genera.
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    An ultrastructural comparison betweenSpermatozopsis andDunaliella (Chlorophyceae) (1984)
    Springer
    Plant systematics and evolution 146 (1984), S. 31-46 
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    ISSN: 1615-6110
    Keywords: Chlorophyceae ; Spermatozopsis ; Dunaliella ; D. salina ; Green flagellates ; ultrastructure ; taxonomy ; systematics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The ultrastructure of the type species of the genusDunaliella, D. salina, has been reinvestigated in an attempt to clarify the relationships betweenDunaliella andSpermatozopsis. Dunaliella salina differs in the following ultrastructural characters fromSpermatozopsis (as exemplified byS. similis Preisig etMelkonian): presence of a distinctive surface coat covering the plasmalemma; presence of a prominent pyrenoid (with pairs of thylakoids partially entering the pyrenoid matrix); dictyosomes parabasal; endoplasmic reticulum closely underlying the plasmalemma around most of the cell; contractile vacuoles absent; cell form ovoid to elongated and not spirally twisted; mitochondrial profiles near the flagellar apparatus. Differences in the ultrastructure of the flagellar apparatus: basal body angle more or less fixed; distal connecting fibre cross-striated; system II fibre (rhizoplast) present, associated with mitochondrial profile; system I fibre underlying two-stranded microtubular root; mating structure present. These ultrastructural differences justify distinction between the two taxa at generic level. The problematical status of “freshwater” species ofDunaliella is briefly discussed.
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    A light and electron microscopical study of the green flagellateSpermatozopsis similis spec. nova (1984)
    Springer
    Plant systematics and evolution 146 (1984), S. 57-74 
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    ISSN: 1615-6110
    Keywords: Chlorophyceae ; Spermatozopsis similis ; Green flagellate ; new species ; algal culture ; electron microscopy ; taxonomy ; phylogeny
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The green flagellateSpermatozopsis similis spec. nova has been studied in culture by light and electron microscopy. The flagellate bears two flagella, is naked and has a characteristic crescent and spirally twisted cell shape. The two flagella are of subequal length, each with a prominent hair-point. Each cell contains two contractile vacuoles, a single chloroplast with an anterior eyespot but lacking a pyrenoid, an anteriorly located nucleus, a single dictyosome associated with the posterior end of the nucleus, a single mitochondrion posterior to the nucleus and associated with a small microbody, some conspicuous vacuoles, and a greater number of secondary cytoskeletal microtubules which probably are responsible for maintaining the peculiar shape of this species. SinceS. similis in culture is only biflagellate, it cannot be accommodated within the quadriflagellate, but otherwise very similar speciesS. exsultans. Spermatozopsis similis is compared with other green flagellates and is shown to share common ultrastructural characters withChlamydomonas-type green algae.
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    Spiniferomonas septispina andS. enigmata, two new algal species confusing the distinction betweenSpiniferomonas andChrysosphaerella (Chrysophyceae) (1984)
    Springer
    Plant systematics and evolution 148 (1984), S. 103-117 
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    ISSN: 1615-6110
    Keywords: Algae ; Chrysophyceae ; Spiniferomonas septispina sp. n. ; S. enigmata sp. n. ; Chrysosphaerella ; Morphology ; taxonomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two new species of non-colonial silica-scaled chrysophytes were discovered in Ontario and were assigned to the genusSpiniferomonas (Chrysophyceae) owing to their solitary cell habit. Scale structure in the two new species is distinctive but includes features common to bothSpiniferomonas andChrysosphaerella. The use of scale structure as the main diagnostic feature to distinguish the two genera is no longer acceptable. A more expedient separation of the two genera based on cell habit (solitary vs. colonial) is proposed and includes the transfer ofChrysospharella salina Birch-Andersen andChrysosphaerella coronacircumspina Wujek & Kristiansen to the genusSpiniferomonas as new combinations. The proposed revision is consistent with existing generic circumscriptions of other ochromonadalean forms with either solitary or colonial cell habit.
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    Über einen intrazellulären Parasiten beiCryptomonas (Cryptophyceae), II. (1984)
    Springer
    Plant systematics and evolution 148 (1984), S. 165-167 
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    ISSN: 1615-6110
    Keywords: Cryptophyceae ; Bodonaceae ; Proteromonas steinii sp. n. ; Cryptomonas spp. div. ; Intracellular parasite ; taxonomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A new intracellular parasite inCryptomonas spp. div. previously known is described asProteromonas steinii spec. nova. The flagellate (infectious) stage isBodo-like, with a distinct kinetoplast. The immobile parasitic stage occurs in the cells of Cryptomonads as a multinucleate trophocyst with a thin mucilage envelope (pseudocyst), while the hypnocyst is uninucleate, walled and bearing two horned projections.
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    Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered (1984)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 575-586 
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    ISSN: 1573-8744
    Keywords: hydrochlorothiazide ; triamterene ; hydroxytriamterene sulfate ; pharmacokinetics ; bioavailability ; renal clearance ; interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Hydrochlorothiazide, triamterene, and hydroxytriamterene sulfate were monitored in the plasma and urine of 24 healthy young men taking single doses of a liquid preparation containing both hydrochlorothiazide and triameterene, liquid preparations containing either of these drugs alone, and a combination tablet recently formulated with a dose ratio of hydrochlorothiazide: triamterene (1∶1,5) found to give optimal potassium-sparing effect. In contradiction to a recent publication, no interaction between the drugs affecting the bioavailability or renal clearance of either could be demonstrated. The previous report of drug-drug interaction probably arose from formulationrelated problems with bioavailability from the two capsule and two tablet products which had been studied. A well-formulated hydrochlorothiazide-triamterene combination tablet promotes plasma concentrations and urinary excretion of hydrochlorothiazide, triamterene, and hydroxytriamterene sulfate which are virtually identical to those seen after either a combination liquid dosage form or simple liquid forms containing only one of the two drugs.
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    Disopyramide pharmacokinetics and bioavailability following the simultaneous administration of disopyramide and14C-disopyramide (1984)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 289-313 
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    ISSN: 1573-8744
    Keywords: protein binding ; pharmacokinetics ; bioavailability ; disopyramide ; heart failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics and bioavailability of total (bound plus unbound) and unbound disopyramide were compared following the simultaneous administration of an oral dose of disopyramide and an intravenous dose of14C-disopyramide in five normal volunteers and in 11 patients with congestive heart failure. The binding of disopyramide varied between 60 and 92% in patients and between 81 and 88% in normal subjects at postequilibrium drug concentrations of 10−7M. The binding of disopyramide to serum protein was concentration-dependent in all study subjects at serum concentrations achieved following drug administration. The association constant for the first binding site in serum from normal subjects and patients averaged 8.7X105 M−1 and 4.4X10 5 M−1, respectively (p 〈 0.05). The unbound clearance of disopyramide averaged 277ml/min and 209 ml/min in normal subjects and in patients (p 〈 0.05). When normalized for body weight, the unbound clearance between patients and normal subjects was not significantly different. The elimination half-life of unbound concentrations in normal subjects and in patients averaged 4.9 and 6.1 h, respectively (p 〈 0.05). The clearance and elimination half-life of total disopyramide was the same in both groups. Although the bioavailability of disopyramide averaged 0.85 in both groups, it was more variable in patients owing to the variability in the fraction of the dose absorbed. The unbound renal clearance and volume of distribution at steady state of disopyramide was related to cardiac index. The ratio of elimination half-lives of total and unbound disopyramide was related to the extent of serum protein binding.
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    Lack of influence of an intensive antacid regimen on theophylline bioavailability (1984)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 315-331 
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    ISSN: 1573-8744
    Keywords: theophylline ; antacids ; interaction ; bioavailability ; steady state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract We examined the influence of a large-volume, therapeutic antacid regimen, administered for three full days, on the steady-state bioavailability of a conventional-release and sustained-release theophylline product, Aminophyllin and Theodur, respectively. Nine stable asthmatics voluntarily completed a four-phase investigation requiring a total stay of 12 days in the Clinical Research Unit. The treatments consisted of administration of the formulations mentioned with and without antacids to each patient in a randomized sequence. Four patients participated in an additional phase where antacids were administered q2h around the clock for three days. After coadministration of theophylline plus antacids for two days, theophylline therapy was discontinued while numerous blood samples were obtained over 22 hr and analyzed for theophylline content via radioimmunoassay. Antacids had no predictable, consistent influence on theophylline absorption rate as determined by the absorption rate constant, the time to maximal theophylline concentration, or the lag time for theophylline absorption. Antacids had no detectable influence on theophylline elimination half-life and had no consistent, statistically significant effect on the extent of theophylline bioavailability, according to measurements of maximal concentration, AUCmeasured over the appropriate steady-state dosing interval, or elimination-rate adjusted AUC.The substantial intraindividual changes for all parameters of theophylline bioavailability that occurred for control and treatment phases likely represent spontaneous, random between-day variability in theophylline disposition independent of antacid administration, as evidenced by the comparability of the percent coefficient of variation for parameters of biovailability across all phases. Our data demonstrate that therapeutic antacid administration has no effect on steady-state theophylline bioavailability and does not alter the intrinsic variability in theophylline absorption. Based on the results of our data, it is unlikely that a clinically significant (〉20%) decrease in theophylline absorption would occur in any patient treated intensively with antacids concurrently.
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    A new statistical procedure for testing equivalence in two-group comparative bioavailability trials (1984)
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    Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 83-91 
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    ISSN: 1573-8744
    Keywords: bioavailability ; bioequivalence ; hypothesis tests ; sample size determination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The clinical problem of testing for equivalence in comparative bioavailability trials is restated in terms of the proper statistical hypotheses. A simple t-test procedure for these hypotheses has been devloped that is more powerful than the methods based on usual (shortest) and symmetric confidence intervals. In this note, this new procedure is explained and an example is given, including the method for sample size determination.
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    Theoretical considerations in the calculation of bioavailability of drugs exhibiting Michaelis-Menten elimination kinetics (1984)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 437-450 
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    ISSN: 1573-8744
    Keywords: first-pass ; bioavailability ; Michaelis-Menten ; volume of distribution ; absorption rate constant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Two approaches used for bioavailability determination of drugs with Michaelis-Menten elimination kinetics were examined by computer simulation. The first method involved treating the drug as though its clearance remained constant during elimination, and the conventional method of taking the ratio of areas under the curve resulting from the oral and intravenous doses was used to calculate bioavailability. The second approach involved using the Michaelis parameters, Vmax and Km,to determine concentration dependent clearance values, but based these calculations on peripheral drug concentrations rather than on concentrations entering or in the liver. We have developed a simulation method that was used to test the accuracy of the above two methods. In the simulations described, Vmax, Km,and hepatic blood flow were chosen to represent a drug with an extraction ratio of 0.9 under linear conditions, but with Michaelis-Menten kinetics occurring at the doses given. Absorption was assumed to be first-order, and metabolism was assumed to occur only in the liver. These simulations showed that the most accurate determination of bioavailability requires knowledge of the direct contribution of oral absorption to the concentration of drug entering the liver. Unexpectedly, the results also showed that if a drug has a large volume of distribution or a large absorption rate constant, or both, use of the much simpler conventional method of bioavailability determination may be appropriate even in cases where the degree of saturation is substantial.
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    The rotifer fauna and population dynamics of Lake Studer 2 (Kerguelen Archipelago) with description ofFilinia terminalis kergueleniensis n. ssp. and a new record ofKeratella sancta Russel 1944 (1984)
    Springer
    Hydrobiologia 108 (1984), S. 57-64 
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    ISSN: 1573-5117
    Keywords: rotifers ; taxonomy ; population dynamics ; biomass
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    Topics: Biology
    Notes: Abstract Filinia terminalis kergueleniensis nov. spp. (FamilyFiliniidae Bartos 1959), from Lake Studer 2 is described and figured.Filinia terminalis kergueleniensis differs from the type in length of bristles and their insertion.Keratella sancta was found again; it is the third record after its discovery by Russel 1944 in New Zealand.Notholca cf.jugosa Gosse 1889 is also found in the plankton of the subantarctic lake. The new subspecies andKeratella sancta occur all year round, whileNotholca cf.jugosa is sporadic. Population dynamics appear to be dependent on changes in temperature and chlorophyll content. We have estimated the relative contribution of these three species to community biomass from their numerical abundance and measured volumes. The major community biomass peak lasts from March to June with a secondary maximum between October and January.
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    Two new and three redescribed species of Viscosia (Nematoda, Oncholaimidae) (1984)
    Springer
    Hydrobiologia 114 (1984), S. 123-147 
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    ISSN: 1573-5117
    Keywords: Nematodes ; freeliving ; marine ; brackish ; taxonomy ; new species ; Viscosia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Viscosia coomansi sp. nov. and Viscosia heterolaina sp. nov. are described from Lake Grevelingen and Eastern Scheldt (The Netherlands). Viscosia glabra (Bastian, 1865) de Man 1890, Viscosia franzii Boucher 1977, and Viscosia viscosa (Bastian 1865) de Man 1890 are redescribed, taking into account new important characters. Juvenile specimens are depicted for V. viscosa. Viscosia carnleyensis Ditlevsen, 1921 is synonymized with Viscosia glabra (Bastian, 1865). Mononcholaimus viscosus Allgén, 1930 and Mononcholaimus elegans sensu Schuurmans-Stekhoven, 1942, 1950 (nec. Kreis, 1924) are synonymized with Viscosia viscosa (Bastian, 1865).
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    The undescribed female of Pseudostenhelia secunda Wells, 1971 (Copepoda Harpacticoida) and keys to the genus (1984)
    Springer
    Hydrobiologia 114 (1984), S. 149-156 
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    ISSN: 1573-5117
    Keywords: female ; Pseudostenhelia secunda ; Copepoda ; Harpacticoida ; taxonomy ; identification keys ; India
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The hitherto unknown female of Pseudostenhelia secunda Wells, 1971 collected from Lake Kolleru, India, is described and illustrated. It can be readily diagnosed inter alia by the abdominal ornamentation, and by the setation of legs 2–4. The original description of the male of this species is supplemented. Further, keys are furnished for identifying both sexes of the three known species of the genus Pseudostenhelia Wells.
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    Some problems in the taxonomy of Chinese species of Gracilaria (Rhodophyta) (1984)
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    Hydrobiologia 116-117 (1984), S. 59-62 
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    ISSN: 1573-5117
    Keywords: seaweed ; Gracilaria ; taxonomy ; systematics ; marine algae ; morphology
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    Topics: Biology
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    Developmental studies on cultured endolithic conchocelis (Rhodophyta) (1984)
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    Hydrobiologia 116-117 (1984), S. 201-208 
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    ISSN: 1573-5117
    Keywords: seaweed ; conchocelis ; endolith ; Rhodophyta ; culture ; development ; taxonomy ; morphology ; influence of substrate mineralogy ; morphometry
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    Topics: Biology
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    A new aspect of Ulva vegetation along the Japanese coast (1984)
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    Hydrobiologia 116-117 (1984), S. 229-232 
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    ISSN: 1573-5117
    Keywords: seaweed ; Ulva ; taxonomy ; phenology
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    Topics: Biology
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    Four new species of Halicyclops Norman, 1903 (Copepoda, Cyclopoida) from Brazil (1984)
    Springer
    Hydrobiologia 119 (1984), S. 107-117 
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    ISSN: 1573-5117
    Keywords: taxonomy ; estuarine crustaceans ; Copepoda ; Halicyclops ; Neotropical Region ; Brazil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Four new species of Halicyclops are described and figured from plankton samples of the brackish waters of Pomonga River, Sergipe State (NE Brazil). The ornamentation of the median apical setae of the furcal rami is proposed as useful diagnostic character for species distinction.
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    Desmoscolecids (Nematode) from New Georgia, Solomon Islands (1984)
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    Hydrobiologia 119 (1984), S. 181-191 
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    ISSN: 1573-5117
    Keywords: Desmoscolecida ; Desmoscolex ; Nematoda ; Solomon Islands ; morphology ; taxonomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two new desmoscolecid species are described: Desmoscolex koloensis sp. nov. and D. parakoloensis sp. nov. Additional information is given on Desmoscolex (Desmolorenzenia) montana, D. sieverti and D. fennicus. The genus Desmolorenzenia is considered a subgenus of Desmoscolex. Pareudesmoscolex lacustris represents a juvenile state of Desmocolex dussarti. Some reflections are made on terrestrial and freshwater desmoscolecids.
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    Taxonomy of Gracilaria: Evaluation of some aspects of reproductive structure (1984)
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    Hydrobiologia 116-117 (1984), S. 41-46 
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    ISSN: 1573-5117
    Keywords: seaweed ; Gracilaria ; spermatangia ; gonimoblast ; tetrasporangia ; taxonomy
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    Topics: Biology
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    Phylogenetic and taxonomic problems in freshwater Oligochaeta with special emphasis on chitinous structures in Tubificinae (1984)
    Springer
    Hydrobiologia 115 (1984), S. 19-23 
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    ISSN: 1573-5117
    Keywords: aquatic Oligochaeta ; Tubificinae ; phylogeny ; taxonomy ; chitinous penis sheaths
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Setae and chitinous penis sheaths are the main characters used to distinguish genera and species of the subfamily Tubificinae. Genital setae and penis sheaths are of functional importance to facilitate copulation. Similar structures in different genera may be homologous or products of parallel evolution (homoiologous). Form and dimensions of the penis sheaths of many tubificine species are very variable. Transspecific overlap of quantitative species characters can make the determination of specimens in the genus Limnodrilus difficult. The configuration of the distal ends of the penis sheaths is an important character to distinguish Limnodrilus species. The definition of the intraspecific variability of this morphological character is problematic.
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    Taxonomic features used in discriminating some central and eastern Pacific species of Gracilaria (1984)
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    Hydrobiologia 116-117 (1984), S. 47-50 
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    ISSN: 1573-5117
    Keywords: seaweed ; Gracilaria ; taxonomy ; marine algae ; red algae ; agarweeds
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    An evaluation of some vegetative features and some interesting problems in Japanese populations of Gracilaria (1984)
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    Hydrobiologia 116-117 (1984), S. 51-54 
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    ISSN: 1573-5117
    Keywords: seaweed ; Gracilaria ; taxonomy ; systematics ; red algae ; Japanese algae
    Source: Springer Online Journal Archives 1860-2000
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    URL: http://dx.doi.org/10.1007/BF00027638
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    The genus Mixodiaptomus Kiefer, 1932 (Copepoda, Diaptomidae) in Spain (1984)
    Springer
    Hydrobiologia 118 (1984), S. 135-146 
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    ISSN: 1573-5117
    Keywords: Copepoda ; Diaptomidae ; taxonomy ; biogeography ; ecology ; Mixodiaptomus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The distribution of the Calanoid genus Mixodiaptomus was studied in a large number of pools and small lakes scattered over Spain. Four species occur: M. incrassatus, M. kupelwieseri, M. ortizi and M. laciniatus, the latter in 2 subspecies (M. laciniatus laciniatus and M. laciniatus atlantis). M. ortizi is described as a new species. M. laciniatus lives in mountains, while all other species occur in the plains. M. incrassatus is found all over the country, M. kupelwieseri only in the eastern part of Catalonia, M. laciniatus atlantis in Andalucia and M. ortizi in the central lands called Mesetas. All live in little mineralized waters and only M. incrassatus and M. laciniatus atlantis occur in clayey waters.
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    URL: http://dx.doi.org/10.1007/BF00021038
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    A canthobrama centisquama Heckel and the validity of the genus Mirogrex Goren, Fishelson and Trewavas (Osteichthyes: Cyprinidae) (1984)
    Springer
    Hydrobiologia 109 (1984), S. 275-278 
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    ISSN: 1573-5117
    Keywords: Cyprinidae ; Middle East ; taxonomy ; zoogeography ; Acanthobrama ; Mirogrex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The poorly known cyprinid fish Acanthobrama centisquama is re-described and its distribution is clarified. It is found in the Orontes basin and not waters around Damascus. The genus Mirogrex is synonymised with Acanthobrama.
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    URL: http://dx.doi.org/10.1007/BF00007745
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    The rotifer fauna and population dynamics of Lake Studer 2 (Kerguelen Archipelago) with description of Filinia terminalis kergueleniensis n. ssp. and a new record of Keratella sancta Russel 1944 (1984)
    Springer
    Hydrobiologia 108 (1984), S. 57-64 
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    ISSN: 1573-5117
    Keywords: rotifers ; taxonomy ; population dynamics ; biomass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Filinia terminalis kergueleniensis nov. spp. (Family Filiniidae Bartos 1959), from Lake Studer 2 is described and figured. Filinia terminalis kergueleniensis differs from the type in length of bristles and their insertion. Keratella sancta was found again; it is the third record after its discovery by Russel 1944 in New Zealand. Notholca cf. jugosa Gosse 1889 is also found in the plankton of the subantarctic lake. The new subspecies and Keratella sancta occur all year round, while Notholca cf. jugosa is sporadic. Population dynamics appear to be dependent on changes in temperature and chlorophyll content. We have estimated the relative contribution of these three species to community biomass from their numerical abundance and measured volumes. The major community biomass peak lasts from March to June with a secondary maximum between October and January.
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    URL: http://dx.doi.org/10.1007/BF00028183
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    The rotifer fauna and population dynamics of Lake Studer 2 (Kerguelen Archipelago) with description ofFilinia terminalis kergueleniensis n. ssp. and a new record ofKeratella sancta Russel 1944 (1984)
    Springer
    Hydrobiologia 108 (1984), S. 57-64 
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    ISSN: 1573-5117
    Keywords: rotifers ; taxonomy ; population dynamics ; biomass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Filinia terminalis kergueleniensis nov. spp. (FamilyFiliniidae Bartos 1959), from Lake Studer 2 is described and figured.Filinia terminalis kergueleniensis differs from the type in length of bristles and their insertion.Keratella sancta was found again; it is the third record after its discovery by Russel 1944 in New Zealand.Notholca cf.jugosa Gosse 1889 is also found in the plankton of the subantarctic lake. The new subspecies andKeratella sancta occur all year round, whileNotholca cf.jugosa is sporadic. Population dynamics appear to be dependent on changes in temperature and chlorophyll content. We have estimated the relative contribution of these three species to community biomass from their numerical abundance and measured volumes. The major community biomass peak lasts from March to June with a secondary maximum between October and January.
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    URL: http://dx.doi.org/10.1007/BF02391633
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    Revision of the African species of the genus Mesocyclops Sars, 1914 (Copepoda: Cyclopidae) (1984)
    Springer
    Hydrobiologia 109 (1984), S. 3-66 
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    ISSN: 1573-5117
    Keywords: Copepoda ; Mesocyclops ; Africa ; revision ; taxonomy ; zoogeography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A revision is made of the African Mesocyclops species, based on type material (when extant) and on collections from various parts in Africa. Diagnostic characteristics are: presence or absence of spinule patterns on antennular segments, structure of the hyaline membrane of the 17th antennular segment, spine pattern on the basipodite of the antenna, armature of the maxillulary palp, presence or absence of a spine on the basipodite of P1, armature of the connecting lamella, coxopodite and basipodite of P4, armature of the apical spines of Enp3P4, armature of the last thoracic segment, genital segment and the other abdominal segments, armature of the furcal rami and structure of the receptaculum seminis. First, the taxonomical status of M. leuckarti (Claus) is redefined; this species does not occur in Africa and its geographical range is restricted to Europe and the western part of Northern Asia. On the African continent, twelve other taxa are found. Four are described as new to science: M. kieferi sp.n., M. dussarti sp.n., M. spinosus sp.n. and M. aequatorialis similis subsp.n. The remainder are: M. major Sars, M. tenuisaccus (Sars), M. paludosus Lindberg, M. salinus Onabamiro, M. ogunnus Onabamiro, M. aspericornis (Daday), M. rarus Kiefer and M. aequatorialis aequatorialis (Kiefer). Their geographical distribution is discussed. Eleven taxa are restricted to the African continent (including the Arabian Peninsula and the Canary Islands). One taxon is also found in the Oriental Region. Madagascan representatives are briefly mentioned. The importance of breeding and cross-breeding experiments should be stressed in copepod taxonomy. Experiments were performed on African species and M. leuckarti to evaluate the morphological characters used in the present study, and intraspecific morphological variability was examined up to and including the third generation (Van de Velde, in press). In future one should critically reconsider the so-called cosmopolitan species; they may indeed represent a complex of related taxa, each with a geographical range more restricted than that of the species-complex itself.
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    URL: http://dx.doi.org/10.1007/BF00006297
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    Remarques taxonomiques sur quelques rotiferès des tourbières avec la description d'une espèce et d'une sous-espèce nouvelles (1984)
    Springer
    Hydrobiologia 109 (1984), S. 125-130 
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    ISSN: 1573-5117
    Keywords: rotifers ; taxonomy ; peat bogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé Des prévisions d'ordre taxonomique sont apportées sur quelques espèces intéressantes de rotifères des tourbières: Lepadella quadricurvata n. sp. et Lepadella koniari arvernae n. ssp. nouvelles pour la science sont d\'ecrites La pr\'esence de trois rares esp\`eces de Lecane (L. lauterborni, L. sagula et L. kluchor) est signal\'ee et leurs variations sont \'etudi\'ees Le probl\`eme de la synonymie de Trichocerca montana Hauer et de T. intermedia (Stenroos) est discut\'e L'existence de formes interm\'ediaires entre trois esp\`eces de Trichocerca (T. porcellus, T. parvula, T. musculus) est soulign\'ee.
    Notes: Abstract Taxonomic notes about peat-bog rotifers with a description of one new species and one new subspecies. Variations and problems about some peat-bog rotifers (especially the genera Lecane and Keratella) are discussed. Descriptions of Lepadella quadricurvata nov. sp. and Lepadella koniari arvernae nov. ssp. are added. {xxCes notes résultent d'une étude effectuée en 1980 dans une dizaine de tourbières du Puy-de-Dôme (France Centrale). Au cours de ce travail nous nous sommes heurtés à quelques problèms interéssants de taxonomie qu'il nous paraît utile de soulever, les rotifères des tourbières restant un domaine peu exploré.}
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    URL: http://dx.doi.org/10.1007/BF00011571
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    A review of the rotifer fauna of the Sudan (1984)
    Springer
    Hydrobiologia 110 (1984), S. 113-130 
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    ISSN: 1573-5117
    Keywords: Sudan ; rotifers ; taxonomy ; biogeography ; Africa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A collection of rotifers contained in samples from the Blue, White and joint Niles in the Sudan, the Red Sea Hills, and Jebel Marra mountains is studied, and the previous literature on the rotifera of Sudan is reviewed. A total of 145 rotifer taxa are now known from this country. Ecological and distributional notes on selected species are added. Besides cosmopolitan, pantropical, and tropical species, a small but significant fraction of the fauna is of northern origin, possibly reflecting climatic conditions of the late-Pleistocene.
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    URL: http://dx.doi.org/10.1007/BF00025783
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    Cladocera from the Sudan: Red Sea Hills, Jebel Marra and valley of the main Nile (1984)
    Springer
    Hydrobiologia 110 (1984), S. 163-169 
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    ISSN: 1573-5117
    Keywords: Sudan ; Cladocera ; biogeography ; taxonomy ; Sudan ; Nile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Twenty species of Cladocera are reported from the Nile, where lacustrine species dominate, and from Jebel Marra and the Red Sea Hills, where chydorids dominate. The community found in the Red Sea Hills is more typically desertic than that of Jebel Marra, which appears closely related to the fauna of the West and Central African Sahel.
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    URL: http://dx.doi.org/10.1007/BF00025787
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    On the freshwater ostracods (Crustacea, Ostracoda) of the Sudan, with special reference to the Red Sea Hills, including a description of a new species (1984)
    Springer
    Hydrobiologia 110 (1984), S. 137-161 
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    ISSN: 1573-5117
    Keywords: Sudan ; freshwater ostracods ; Africa ; taxonomy ; zoogeography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A collection of freshwater ostracods from the Sudan is studied and 18 species are recorded. Paracypretta amati sp.n. is new to science. A redescription of the holotype female of Paracypretta aratra (Brady, 1904) (not recorded in this collection) and a provisional key to the species of Paracypretta are given. Heterocypris giesbrechtii (G. W. Müller, 1898) is re-described; Heterocypris sobrinus (Masi, 1932) is placed in the synonymy of H. fretensis; Hemicypris intermedia (Lindroth, 1953) is recorded for the first time since its original description and is redescribed, while Cyprinotus largereticulatus Rome, 1969 is transferred to Hemicypris. The zoogeographical composition of this fauna is briefly discussed.
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    URL: http://dx.doi.org/10.1007/BF00025786
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    The calanoid copepods of the Nile system (1984)
    Springer
    Hydrobiologia 110 (1984), S. 191-212 
    Details
    ISSN: 1573-5117
    Keywords: Sudan ; Copepoda ; Calanoida ; taxonomy ; biogeography ; Africa ; Nile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract At least 11 or 12 calanoid taxa occur in the Nile system. One species is typical of the river and of Lake Chad (Th. galebi); two are restricted to Lake Victoria (Th. galeboides, T. stuhlmanni), but both might be only subspecies to more widespread species. One is restricted to Lakes Edward and George (T. worthingtoni) but is a little known species. No calanoids are on record from Lakes Albert and Kyoga, while the species reported from Lake Turkana (T. banforanus) is out of range, and almost certainly represents an erroneous record. Among the remaining species, four are East-African, ranging from the southern tip of the continent to the Ethiopian plateau and the Nile valley (P. schultzei, Th. mixtus, T. kraepelini, T. cf orientalis), while two are Sahelian species that span Africa from east to west (M. mauretanicus, T. processifer et ssp.). Two new synonyms are introduced. One new subspecies (T. processifier friedae) is described from the Ethiopian plateau. It is suggested that Tropodiaptomus orientalis (Brady, 1886), the type species of its genus, should not be considered a nomen dubium, but should be redescribed on its type female(s) and on topotypical males from Sri Lanka.
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    Caractères taxinomiques et spécificité dans le genreAsplanchna (Rotifère) (1984)
    Springer
    Hydrobiologia 112 (1984), S. 41-44 
    Details
    ISSN: 1573-5117
    Keywords: rotifers ; Asplanchna ; taxonomy ; specificity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A comparative analysis of eight characters in two clones ofA. brightwelli and a clone ofA. intermedia, fed withParamecium orBrachionus, is made to determine the intraclonal, interclonal and interspecific variations in this complex of species. The trophi morphology appears the most species specific criterium whereas the other features (size of males, diameter and ornamentation of resting eggs, nuclear number in syncytial glands) show variability, either genetic or related to environmental conditions. The variation observed in the ornamentation of resting eggs and in the nuclear number of vitellogen was distributed along a continuous gradient.
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    URL: http://dx.doi.org/10.1007/BF00007664
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