Summary
In 7 healthy subjects (3 males and 4 females), the kinetics of nadolol was investigated after oral doses of 60 and 120 mg. The t1/2 was 14.0±1.8 h. The peak plasma level was doubled on doubling the dose (from 69±15 to 132±27 ng/ml, respectively) and the urinary excretion (13.5%) rose similarly. The half-life of elimination was longer at night than in the day, probably because of the slower nocturnal flow of urine.
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Schäfer-Korting, M., Bach, N., Knauf, H. et al. Pharmacokinetics of nadolol in healthy subjects. Eur J Clin Pharmacol 26, 125–127 (1984). https://doi.org/10.1007/BF00546720
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DOI: https://doi.org/10.1007/BF00546720