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  • Mutation
  • Phosphorylation
  • American Association for the Advancement of Science (AAAS)  (10)
  • American Institute of Physics (AIP)
  • 2005-2009
  • 1980-1984  (10)
  • 1981  (10)
Collection
Publisher
  • American Association for the Advancement of Science (AAAS)  (10)
  • American Institute of Physics (AIP)
  • Springer  (4)
Years
  • 2005-2009
  • 1980-1984  (10)
Year
  • 1
    Publication Date: 1981-07-31
    Description: Benzodiazepines inhibit Ca2+-calmodulin-stimulated membrane protein phosphorylation. The effects of the benzodiazepines on protein phosphorylation are stereospecific and produced by membrane-bound benzodiazepine. The potency of benzodiazepine kinase inhibition is correlated with the ability of the benzodiazepines to inhibit electric shock-induced convulsions. These findings provide evidence that some of the anticonvulsant and neuronal stabilizing effects of benzodiazepines may be modulated by the Ca2+-calmodulin protein kinase system and indicate that this calmodulin-kinase system represents an identifiable benzodiazepine receptor in brain that is distinquishable by several criteria from the previously described high affinity benzodiazepine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeLorenzo, R J -- Burdette, S -- Holderness, J -- NS 1352/NS/NINDS NIH HHS/ -- NSI-EA-1-K04-NS245/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):546-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/metabolism ; Brain/*enzymology ; Calcium/*pharmacology ; Calcium-Binding Proteins/*pharmacology ; Calmodulin/*pharmacology ; Cell Membrane/enzymology ; Chlordiazepoxide/*pharmacology ; Diazepam/*pharmacology ; Enzyme Activation ; Kinetics ; Molecular Weight ; Phosphorylation ; Protein Kinases/*metabolism ; Rats ; Receptors, Drug/metabolism ; Receptors, GABA-A
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1981-04-24
    Description: The chromosomes of the ovarian nurse cells of Drosophila melanogaster fall apart during their cycles of endoreduplication. However, chromosomal synapsis occurs in the pseudonurse cells produced in certain mutant females. The resulting polytene chromosomes undergo developmental changes that are strikingly different from those recorded for the giant chromosomes of the larval salivary gland cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, R C -- Riley, S F -- Cassidy, J D -- White, P E -- Paik, Y K -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):441-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6782674" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatin/ultrastructure ; Chromosome Inversion ; Chromosomes/*ultrastructure ; DNA Replication ; Drosophila melanogaster/*genetics ; Female ; Heterochromatin/ultrastructure ; Mutation ; Ovarian Neoplasms/genetics/veterinary ; Ovary/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1336-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259729" target="_blank"〉PubMed〈/a〉
    Keywords: Abelson murine leukemia virus/enzymology ; Alpharetrovirus/enzymology ; Animals ; Avian Sarcoma Viruses/enzymology ; Cell Adhesion ; *Cell Transformation, Viral ; Glycolysis ; Humans ; Oncogene Protein pp60(v-src) ; Oncogenic Viruses/*enzymology ; Phosphoproteins/physiology ; Phosphorylation ; Protein Kinases/*physiology ; Tumor Virus Infections/*enzymology ; Tyrosine/metabolism ; Viral Proteins/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1981-05-01
    Description: The kinetic patterns of DNA synthesis in wild-type (RAD+) and rad 52 mutants of yeast, which exhibit high levels of synchrony during meiosis, are comparable. However, RAD 52 mutants accumulate single-strand breaks in parental DNA during the DNA synthesis period. Thus, the product of the RAD 52 gene has a role in meiotic DNA metabolism, as well as in the repair of DNA damage during mitotic growth. The observed breaks may be unresolved recombination intermediates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Resnick, M A -- Kasimos, J N -- Game, J C -- Braun, R J -- Roth, R M -- 5 R01 GM17317-11/GM/NIGMS NIH HHS/ -- S07-RR07027/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 May 1;212(4494):543-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7010606" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA Repair ; DNA, Fungal/genetics ; DNA, Single-Stranded/genetics ; Genes ; *Meiosis ; Molecular Weight ; Mutation ; *Recombination, Genetic ; Saccharomyces cerevisiae/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1981-01-02
    Description: Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adams, P M -- Fabricant, J D -- Legator, M S -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):80-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444453" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning ; Behavior, Animal/*physiology ; Cyclophosphamide/*pharmacology ; Female ; Locomotion ; Male ; Motor Activity ; Mutation ; Rats ; Spermatogenesis/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1981-01-30
    Description: Phosphorylation of the 20,000-dalton light chain of myosin is closely correlated with cross-bridge cycling in arterial smooth muscle. Evidence is presented that dephosphorylation can produce an attached, noncycling cross-bridge (latch-bridge) which is responsible for the high economy of force maintenance in this tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dillon, P F -- Aksoy, M O -- Driska, S P -- Murphy, R A -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):495-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6893872" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Animals ; Calcium/physiology ; Carotid Arteries/*physiology ; Macromolecular Substances ; *Muscle Contraction ; Muscle, Smooth/*physiology ; Myosins/*metabolism ; Phosphorylation ; Protein Kinases/metabolism ; Swine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-04-24
    Description: Five ICR-170--induced mutations at the His4 locus in yeast are +1 G.C (G, guanine; C, cytosine) additions in DNA regions that contain multiple G.C base pairs. These mutations represents both nonsuppressible and suppressible alleles. All externally, suppressible frameshift mutations occur in glycine and proline codons to produce the four-base codons GGGU (U, uracil), GGGG, and CCCU. This implies that suppression of these four-base codons in yeast, as in bacteria, involves a four-base anticodon or its functional equivalent. Two identical four-base codons (CCCU) at widely separate regions with His4 are not suppressed equally.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donahue, T F -- Farabaugh, P J -- Fink, G R -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):455-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7010605" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; *Codon ; DNA, Fungal/genetics ; Glycine/*genetics ; Histidine/genetics ; Mutation ; Proline/*genetics ; *RNA, Messenger ; Saccharomyces cerevisiae/*genetics ; *Suppression, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 1981-10-23
    Description: The active portion of the alpha subunit of pyruvate dehydrogenase in rat frontal cortex was elevated after a training experience. No change in total pyruvate dehydrogenase activity was observed. The phosphorylation in vitro of pyruvate dehydrogenase (band F-2) was also elevated after training. Since activation of pyruvate dehydrogenase requires its dephosphorylation, the following sequence is proposed. Training alters frontal cortex and reduces the phosphate content of pyruvate dehydrogenase in vivo; this leads to enzyme activation; and an increase in back-titration of sites available for phosphorylation in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morgan, D G -- Routtenberg, A -- MH25281/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):470-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/*physiology ; Brain/*enzymology ; Male ; Neuronal Plasticity ; Phosphoproteins/metabolism ; Phosphorylation ; Pyruvate Dehydrogenase Complex/*metabolism ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 1981-09-18
    Description: The relationship between the actin-activated adenosinetriphosphatase activity of smooth muscle myosin and the extent of myosin light chain phosphorylation is nonlinear. It is suggested that the phosphorylation of the two heads of smooth muscle myosin is an ordered process and that the two heads are influenced by cooperative interactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Persechini, A -- Hartshorne, D J -- HL 23615/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 18;213(4514):1383-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6455737" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/pharmacology ; Adenosine Triphosphatases/metabolism ; Allosteric Regulation ; Animals ; Chickens ; Enzyme Activation/drug effects ; Gizzard ; Macromolecular Substances ; Muscle, Smooth/*metabolism ; Myosin-Light-Chain Kinase ; Myosins/*metabolism ; Phosphorylation ; Protein Kinases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russell, E S -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1074, 1076.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6946561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Disease Models, Animal ; Dogs ; *Genetic Engineering ; *Genetics, Medical ; Humans ; Mice ; Mutation ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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