ALBERT

Description / Table of Contents: Preface -- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction -- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System -- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function -- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression -- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target -- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease -- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor -- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders -- The Role of D3 Dopamine-Receptors in Nicotine Dependence: A Synthesis of the Pre-Clinical and Clinical Literature -- The Dopamine D3 receptor in Food Addiction -- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia -- D3 receptors and Restless Legs Syndrome -- D3 receptors and PET imaging.

Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.

Description / Table of Contents: 1 Introduction -- Part I: Forest and woodland biomes -- 2 White sand ecosystems in the Amazon basin: geographic distribution, distinctive features, and ecology. An overview -- 3 The forests of the Rio Negro basin in the north-western Amazon: a phytosociological classification -- 4 Amazon caatinga complex: sclerophyllous vegetation on nutrient-poor white sand soils -- Part II: Meadow biomes -- 5 Mapping white-sand ecosystems by integrating Global PALSAR-2 and SENTINEL-1 with NDVI (LANDSAT data) -- 6 The study areas: landscapes and soils -- 7 Soil properties, formation, distribution, and classification -- 8 Origin and sources of sand: from highlands to lowlands -- 9 Sand dynamics and distribution: a geo-sedimentological approach -- 10 Features and trends of meadow landscape evolution -- 11 Meadow phytodiversity: flora, endemism, vegetation types, and geographic distribution patterns -- 12 Synthesis: white-sand and meadow-vegetation relationships.

Description / Table of Contents: 1. What do we know about mammal movement in African tropical forests? -- 2. Movements patterns and population dynamics of giant forest hog groups in Kibale National Park, Uganda -- 3. Forest elephant movements in Central Africa – megafauna need megaspaces -- 4. Elephant movements, abundance and use of water sources in Kibale National Park, Uganda -- 5. Movement ecology and evolutionary history of forest buffalo -- 6. Site fidelity and home range shifts in a leaf-eating primate -- 7. Primate movements across the nutritional landscapes of Africa -- 8. Conditions facilitating a “landscape of fear from disease” in African forest mammals -- 9. Do seasonally frugivory and cognition shape foraging movements in wild western gorillas? -- 10. Females Move in Tight Crowds, Males Roam: Society and Movement Ecology of Mandrills -- 11. Linking Movement Ecology to Conservation Biology.

Description / Table of Contents: Preface -- Practical Aspects of NMR-Based Metabolomics -- Compound Identification in Mass Spectrometry-Based Metabolomics -- METABOLOMICS USING NMR – Avoiding the ‘Black-Box’ -- Natural products drug discovery: on silica or in silico?- Quantitative NMR Methods in Metabolomics -- Advancements in pulsed stable isotope resolved metabolomics -- Metabolomics in Cell Biology -- NMR-based metabolomics to evaluate individual response to treatments -- Pharmacometabolomics of Asthma as a road map to Precision Medicine -- Prospective metabolomic studies in precision medicine -- Chemotherapy-induced Peripheral Neuropathy -- Metabolomics of Respiratory Diseases.

Description / Table of Contents: Introduction -- Biomes: Concepts, Characteristics and Terminology -- Profiles of Angola’s Biomes and Ecoregiens -- Landscapes: Geology, Hydrology and Geomorphology.

Description / Table of Contents: Preface -- Part 1 Modulation -- Cav1.1Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies -- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia -- Sympathetic Nervous System Regulation of Cardiac Calcium Channels -- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19 -- Part 2 Pharmacological Approaches -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits -- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors -- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies -- CACNA1C-Related Channelopathies -- CACNA1D-Related Channelopathies: From Hypertension to Autism -- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options -- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits.

Description / Table of Contents: Part 1: Introduction to squirrels of the world and their conservation trends. Chapter 1: The World’s Squirrel Taxonomy -- Chapter 2: Evolution, habitat trends, and extinction rate estimates of the world squirrels -- Part 2: Squirrels of the world in the Anthropocene. Chapter 3: Habitat Trends and the Squirrel-Human Interface -- Chapter 4: A Meta-analysis based on Open Access Big Data Mining of Global Predicted Squirrel Distribution Models with Machine Learning for IUCN Conservation Status and Trend Policy Assessments -- Chapter 5: Squirrels in Cities -- Chapter : Squirrels in the Tropics -- Chapter 7: Squirrels on Islands -- Chapter 8: Tree squirrels in old-growth forests? -- Chapter 9: Can squirrels be used as indicators to identify and protect old-growth forest reserves? -- Chapter 10: Squirrel Economics -- Part 3: Problems and governance in the squirrel world. Chapter 11: Squirrel Hunting Regulations and Enforcement (Or Lack Thereof) -- Chapter 12: Where do the World’s Squirrel Hotspots and Coldspots of 230+ species go with Climate change 2100? -- Chapter 13: Squirrel’s marginalization and modern lack of conservation and poor sustainability outlook as a call to good action -- Part 4: First conclusions and the way forward. Chapter 14: A Conservation Management SWOT analysis for over 300 Squirrels of the World using 132 GIS layers confirming the PESTLE assessment -- Chapter 15: First Conclusions, Success stories, and Calls-to-action for the conservation of the world’s squirrels.

Description / Table of Contents: 1. Introduction to Rangeland Wildlife Ecology and Conservation -- Part I Rangeland Ecosystems and Processes -- 2. Rangelands of Western North America -- 3. A History of North American Rangelands -- 4. Western Rangeland Livestock Production Systems and Grazing Management -- 5. Manipulation of Rangeland Wildlife Habitats -- 6. Role and Management of Fire in Rangelands -- 7. Water is Life: Importance and Management of Riparian Areas for Rangeland Wildlife -- 8. Rangeland Biodiversity -- Part II Species Accounts -- 9. Prairie Grouse -- 10. Sage-Grouse -- 11. Quails -- 12. Rangeland Songbirds -- 13. Wetland Birds of Rangelands -- 14. Avian Predators in Rangelands -- 15. Burrowing Rodents -- 16. Mesocarnivores of Western Rangelands -- 17. Black-tailed and Mule Deer -- 18. White-tailed Deer -- 19. Pronghorn -- 20. Elk -- 21. Feral Equids -- 22. Mountain Ungulates -- 23. American Bison -- 24. Large Carnivores -- 25. Amphibians and Reptiles -- 26. Insects in Grassland Ecosystems -- Part III Social-Ecological Considerations -- 27. Wildlife, Rural Communities, and the Rangeland Livelihoods they Share: Opportunities in a Diverse Economies Approach -- 28. Living with Predators: A 20-year Case Study in the Blackfoot River Watershed of Montana -- 29. A Perspective on Rangeland and Wildlife Disciplines: Similarities Over Differences -- 30. Future of Rangeland Wildlife in North America.

Description / Table of Contents: Part I - Money and its role in the economy -- 1. Introduction: the world is on a collision course -- 2. What is money? -- 3. Money is like the ‘blood’ of the economy -- Part II Money and the unsustainability in stricto sensu -- 4. The growth imperative inherent in our financial system -- 5. The effect of the money interest rate on money supply, demand and growth -- 6. Economic growth in the long run is unsustainable -- 7. Economic growth or unemployment -- Part III. Money and inequality -- 8. Our current monetary system produces income inequality -- 9. Moral-ethic aspects of interest-induced inequality -- Part IV Natural money as solution -- 10. Gesell’s solution -- 11. Gesell’s Solution to achieve the SDGs -- 12. How to implement Gesell’s solution in today’s world -- 13. Alternatives to Gesell’s solution -- 14. Experiences with Gesell’s solution -- Part V Outlook and final considerations -- 15. Towards a Development at Human Scale -- 16. Economic resilience in presence of externals shocks -- 17. Final considerations.

Description / Table of Contents: Part 1 Pharmacological Basic Principles -- The impact of sex and gender in medicine and pharmacology -- Sex differences in pharmacokinetics -- Clinical pharmacological considerations in transgender medicine -- Sex and gender differences in the pharmacology of the overactive urinary bladder -- Part 2 Pathologies of the Brain -- Sex differences in the evaluation and treatment of stroke -- Sex differences in pain and its treatment -- Therapeutics For Substance-Using Women: The Need To Elucidate Sex-Specific Targets For Better-Tailored Treatments -- Intersection of sex and depression: pathogenesis, presentation and treatments -- Biological and clinical implications of sex-specific differences in Alzheimer’s disease -- Part 3 Diabetes, metabolic diseases & cardiovascular risk -- Gender Differences In Cardiovascular Health: Hormonal Effects on Cardiovscular Risk And Management. - Sex Differences in Glucose Homeostasis -- Sex-gender-based differences in metabolic diseases -- Hypothalamic pituitary gonadal axis disorders impacting fertility in both sexes and the potential of kisspeptin-based therapies to treat them.

Description / Table of Contents: 1- Basic concepts of ecology applied on the neotropic ecosystems -- 2 - Natural resources and sustainable development in Peru -- 3 - Classification of the Peruvian Ecosystems -- 4 - Peruvian ecosystems geography -- 5 - Biodiversity and endemism of the Andes -- 6 - Ecological communities, populations and metapopulations -- 7 - Succession and change of the ecosystems -- 8 - Biodiversity of the Amazonia Basin -- 9 - Peruvian protected natural areas -- 10 - The paramo ecosystems -- 11 - The Humboldt National Forest -- 12 - The Northwest Biosphere Reserve -- 13 - Urban ecosystems and development -- 14 - Climate changes -- 15 - Traditional land-use systems and agrobiodiversity in Peru -- Index.

Description / Table of Contents: Part I: Physiological Functions of Endo-lysosomal Cation Channels -- NAADP-Mediated Ca2+ Signalling -- NAADP-Dependent TPC Current -- NAADP-Evoked Ca2+ Signaling: The DUOX2–HN1L/JPT2–Ryanodine Receptor 1 Axis -- TPC Functions in the Immune System -- Lysosomal Ion Channels and Lysosome– 1 Organelle Interactions -- TRPML1 and TFEB, an Intimate Affair -- Lysosomal Potassium Channels -- Part II Structure and Composition of TPC and TRPML Channels -- Structure and Function of Plant and Mammalian TPC Channels -- A Structural Overview of TRPML1 and the TRPML Family -- Endo-Lysosomal Two-Pore Channels and Their Protein Partners -- Part III: Tools and Methods to Characterize Endolysosomal Cation Channels -- Electrophysiological Techniques on the Study of Endolysosomal Ion Channels -- The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channels -- Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels -- Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging.

Description / Table of Contents: Introduction -- Development, anatomy and histology of the mesentery -- The mesenteric intersitium -- Mesnteric organ lymphatics -- The mesentery as an immunological organ -- Bacterial translocation to the mesentery -- The microbiome of mesenteric lymh nodes -- Mesenteric Adenopathy and adenitis -- The effects of mesenteric inflammation on the intestine -- The mesentery as an ADME organ -- Targteing the mesentery using surgery -- Future directions.

Description / Table of Contents: 1. Agro-biodiversity across the food chain -- 2. Emerging risks to plant health -- 3. Future-proofing Plants against Climate Change- A path to ensure Sustainable Food Systems -- 4. The role of Integrated Pest Management for sustainable food production: The soybean example -- 5. (Alternative approaches to pesticide use): Plant-derived pesticides -- 6. Antimicrobial use in animal food production -- 7. Impacts of environment-friendly unit operations on the functional properties of bee pollen -- 8. Microbiome applications for sustainable food systems -- 9. Healthier and sustainable food systems: integrating underutilized crops in a ‘Theory of Change Approach -- 10. Alternative proteins for food and feed.

Description / Table of Contents: Part 1. Pharmacogenomics -- Building evidence in RCTs Implementation of pharmacogenomics in healthcare in the UK -- Part 2. Precision medicine in clinical entities -- Precision medicine in therapy of non-solid cancer -- Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia -- Precision medicine in Asthma -- Precision medicine in Diabetes -- Precision Medicine in Antidepressants Treatment -- Precision Medicine in Neuropathic Pain -- Part 3. Techniques in Precision Medicine -- Imaging techniques in pharmacological precision medicine -- Challenges to use NGS data to optimize drug therapy -- Part 4. Economics -- Pharmacoeconomics in precision medicine. .

Description / Table of Contents: 1. Introduction. Randall W. Myster -- 2. Mountain gradients in the Neotropics, a bracken fern perspective. Jorge Luis Avila Nuñez, Maria Pia Calcagno-Pissarelli, Miguel E. Alonso-Amelot -- 3. Effects of agricultural expansion on lotic benthic macroinvertebrate communities: a review and case study from Brazil. Elaine C. Corrêa and Ryan M. Utz -- 4. Plant competition across topographic gradients in Neotropical Cerrado savannas: an isotopic approach. Davi R. Rossatto and Augusto C. Franco -- 5. Diversity of aquatic macroinvertebrates along altitudinal gradients in Colombian. Cesar E. Tamaris-Turizo, Gabriel A. Pinilla-A and Juan D. González-Trujillo -- 6. Intraspecific trait variability of emblematic grass and tree species from Venezuelan savannas across extended physical gradients. Zdravko Baruch -- 7. Latitudinal trends in scorpion assemblages of Brazilian Atlantic Forest: do the Rapoport’s and Bergmann’s rules apply? André F.A. Lira, Alessandra R.S. Andrade and Stênio I.A. Foerster -- 8. Species diversity of three faunal communities along a successional cloud forest gradient. Juan Manuel Díaz-García, Fabiola López-Barrera, Eduardo Pineda, Jorge Valenzuela-González and Adriana Sandoval-Comte -- -- 9. Ecohydrological gradient in Neotropical montane ecosystems: From tropical montane forests to glacier. Conrado Tobón, Erick Castro, and Jorge Luís Ceballos -- 10. Communities of small terrestrial arthropods change rapidly along a Costa Rican elevation gradient. M. Alex Smith, Connor Warne, Kate Pare, Sarah Dolson, Elyssa Loewen, Kelsey Jones, Megan McPhee, Lauren Stitt, Lauren Janke, Rebecca M. Smith, Heather Coatsworth, Alexandre M. M. C. Loureiro, Angel Solis, Carlos F. Viquez, Josephine Rodriguez, Jose Fernandez-Triana, Michael J. Sharkey, James Whitfield, Alejandro Masís, María Marta Chavarría, Roger Blanco, Felipe Chavarria, Eugenie Phillips-Rodríguez, Roberto Fernández, Dunia Garcia, Guillermo Pereira, Harry Ramirez, Manuel Pereira, Winnie Hallwachs and Daniel H. Janzen -- 11 Neotropical gradients of insect groups in Brazilian mountains. Lucas Neves Perillo, Frederico de Siqueira Neves, Flávio Siqueira de Castro and Ricardo Ribeiro de Castro Solar -- 12. Altitudinal Pattern of Soil Organic Carbon and Nutrients in a Tropical Forest in Puerto Rico. Dingfang Chen, Mei Yu, Grizelle González, Qiong Gao -- 13. Elevational and latitudinal species richness patterns of dung beetles in North and South America and the role played by historical factors. Jorge M. Lobo and José Gutiérrez -- 14. Diversity patterns of vascular plant groups along gradients of elevation and disturbance in Mexico. Jorge A. Gómez-Díaz, Alma P. Bautista-Bello, César I. Carvajal-Hernández, Valeria Guzmán-Jacob, María Leticia Monge-González and Thorsten Krömer -- 15 Gradients and the Structure of Neotropical Metacommunities: Effects of Disturbance -- Elevation, Landscape Structure, and Biogeography. Steven J. Presley, Michael R. Willig -- 16. Socioecological gradients: contesting traditional ecoclines to explain the high biocultural diversity of the Andean verdant. Fausto Sarmiento, Andreas Haller, Domenico Branca, Christiam Aguirre, Vladimir Kremsa, Carla Marchant, Masahito Yoshida -- 17. Conclusions, synthesis and future directions. Randall W. Myster.

Description / Table of Contents: Part 1: Quality by Design (QbD) -- Chapter 1. Pharmaceutical Quality by Design (QbD) overview and major elements -- Chapter 2. Fundamentals of design of experiments and optimization: designs for factor screening and data analysis in pre-response surface methodology -- Chapter 3. Fundamentals of design of experiments and optimization: experimental designs in response surface methodology -- Chapter 4. Fundamentals of design of experiments and optimization: data modeling in response surface methodology -- Chapter 5. Quality by Design in pharmaceutical product and process development -- Chapter 6. A Quality by Design update on nano-drug delivery systems -- Chapter 7. Control strategies of solid dosage forms by PAT tools -- Part 2: Analytical Quality by Design (AQbD) -- Chapter 8. Analytical Quality by Design Fundamentals, Compendial and Regulatory Perspectives -- Chapter 9. Analytical Target Profile (ATP) and Method Operable Design Region (MODR) -- Chapter 10: Quality by Design applications to development of analytical methods for quality control of pharmaceuticals -- Chapter 11. Design of Experiments Applied to the Extraction of Active Compounds. .

Description / Table of Contents: Chapter 1. Introduction -- Chapter Two. Theories and Models -- Chapter 3. The Structure of Macroecological Data -- Chapter 4. Structure and Dynamics of Geographic Ranges -- Chapter 5. The Macroecological Understanding of Ecological Niches -- Chapter 6. Richness and Diversity Patterns -- Chapter 7. Macroecological Assemblages -- Chapter 8. Patterns in Body Size -- Chapter 9. From Theoretical to Applied Macroecology -- Chapter 10. Concluding Remarks. .

Description / Table of Contents: PART I. Polypharmacology as a New Branch of Pharmacology: Concept and Principles -- Basics of Polypharmacology -- Polypharmacology in Clinical Applications: Multitarget Multidrug-combination (MTMD-C) -- Polypharmacology in Clinical Applications: Multitarget Multidrug-single-formulation (MTMD-SF) -- Polypharmacology in Clinical Applications: Multitarget Single-drug (MTSD) -- Polypharmacology in Drug Discovery: Designed Epigenetic MTSD and Small-molecule MTSD -- Anti-cancer Polypharmacology -- Cardiovascular Polypharmacology -- Neuronal Polypharmacology -- Pulmonary Polypharmacology -- Polypharmacology of Metabolic Disease -- Polypharmacology of Infectious Disease -- Polypharmacology of Inflammation -- Anti-psychotics Polypharmacology -- Anti-aging Polypharmacology -- Polypharmacology in Drug Repurposing -- Polypharmacology and Unintended Drug Promiscuity -- Polypharmacology Pharmacokinetics -- The Future of Polypharmacology -- PART II. Polypharmacology in New Drug Development: Strategies and Protocols -- Designed MTSD Discovery Process -- Designed MTSD Discovery Strategies -- Designed MTSD Discovery Technologies -- Designed MTSD Discovery Databases -- Designed MTSD Target Deconvolution.-Designed MTSD Target Validation -- Designed MTSD Lead Identification and Optimization -- Designed MTSD Discovery Protocols -- Natural Products in MTSD Discovery -- Polypharmacology Procedures for Drug Repurposing -- Polypharmacology Procedures for Drug Promiscuity Discovery.

Description / Table of Contents: 1 General Introduction -- 2 Peace Ecology in the Anthropocene for Africa -- 3 Civil Society, Climate Change, Security Risks Management and Peacebuilding in the Anthropocene -- 4 Faith-based Organisations and Environmental Peace: Impact of Laudato Si’ and Its Relevance in the Anthropocene -- 5 Healing Nature and Creation in the Anthropocene: A Reflection on the Role of Religion -- 6 Empowering Women to Build Peace: A Case Study of Grace to Heal Trust in Lupane District -- 7 Peacebuilding through Indigenous Knowledge Systems: Lessons from Civil Society Organisations in Zimbabwe -- 8 Civil Society and Peacebuilding in the Kivu Provinces of the Democratic Republic of Congo -- 9 Zimbabwe’s National Peace and Reconciliation Commission and Civil Society: Partners in Peacebuilding? -- 10 Civil Society and Peacebuilding in the Democratic Republic of Congo: Opportunities, Challenges and Recommendations -- 11 Promoting Democratisation in DR Congo: The Case Study of Act for Transparent and Peaceful Elections -- 12 Civil Society Organisations and School Peace Clubs in South Africa: An Outcome Evaluation -- 13 The Challenges and Opportunities for Civil Society in Peacebuilding: Lessons from the Matabeleland Collective, Zimbabwe -- 14 The Role of Civil Society Participation in Social Cohesion Processes in KwaZulu-Natal, South Africa.-15 Building the Capacity of Civil Society Organisations in Nonviolent Campaigning: A Case Study from South Sudan -- 16 How Informal Peace Committees Complement Macro-infrastructures for Peace in Zimbabwe -- 17 Protecting and Nurturing Children Born from Rape in South Kivu Communities: A Challenge for Civil Society -- 18 Indigenous Peacebuilding Approaches and the Accountability of Former Child Soldiers: African Case Studies -- 19 Navigating Channels for Civil Society Participation in Conflict Prevention and Peace-Making in the African Peace & Security Architecture -- 20 Centre-periphery Relations Between Civil Society Organisations and External Funding Partners: A Case Study of South Kivu’s Peace and Development Agenda. .

Description / Table of Contents: Part I Anatomy, Physiology and Pharmacology of Macrophages -- Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective -- Introduction to Pharmacology of Macrophages from Drug Delivery Perspective -- Mechanisms and Ways of Macrophage Delivery -- Macrophage Associated Disorders: Pathophysiology, Treatment Challenges and Possible Solutions -- Understanding Macrophage Associated Diseases and Applications of Nano Drug Delivery Systems -- Part II Polymeric Nanoparticles for Macrophage Targeting -- Targeting of Macrophages: Basic and therapeutic Role of Polymeric Nanoparticles -- Polymeric Nanoparticles Based Drug and Gene Delivery to Macrophages -- Surface Modification of Nanoparticles for Macrophage Targeting -- Part III Lipid Nanoparticles for Macrophage Targeting -- Liposomes as Delivery System for Macrophage Targeting -- Solid Lipid Nanoparticles Based Drug and Gene Delivery to Macrophages -- In vivo Fate of Colloidal Carriers Undergoing Macrophage Targeting -- Nanoparticle-based Theranostics for Macrophage-associated Diseases -- Part IV Targeting Macrophages for Treatment of Various Diseases -- Tumor Associated Macrophages as Therapeutic Target for Drug/immune Therapy of Cancer -- Macrophage Targeting for Therapy of Autoimmune Diseases -- Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD) -- Macrophage targeting for therapy of intracellular infections -- Targeting Drugs and Nucleic Acids to Macrophages for Therapy of Inflammatory Diseases -- Macrophage Targeted Chemotherapy for Tuberculosis and other Respiratory Disease. -- Part V Specific Formulations and Clinical Trials on Macrophage Targeted Delivery -- Nano- and Microparticles Based Dry Powder Inhalers for Pulmonary Macrophage Drug Delivery -- Recent Trends in Clinical Studies on Macrophage Targeted Delivery -- Future Directions and Challenges in Macrophage Targeting. .

Description / Table of Contents: Chap 1: Disturbance ecology: a guideline -- Chap 2: Definitions and quantifications -- Chap 3: Concepts -- Chap 4: Abiotic disturbances -- Chap 5: Biotic disturbances -- Chap 6: Anthropogenic disturbances -- Chap 7: Disturbances in global change -- Chap 8: Disturbances and management.

Description / Table of Contents: Therapeutic and toxic concentration of drugs in biological matrices -- Analytical techniques for therapeutic drug monitoring and clinical toxicology -- Plasma therapeutic drug monitoring and clinical toxicology -- Dried blood spots in therapeutic drug monitoring and toxicology -- The role of artificial intelligence in therapeutic drug monitoring and clinical toxicity -- Therapeutic drug monitoring and optimal pharmacotherapy with medicines of narrow therapeutic index -- Therapeutic drug monitoring (TDM) and toxicological studies in alternative biological matrices -- Analyzing data from therapeutic drug monitoring, pharmacokinetics, and clinical toxicology studies -- Reducing toxicity in critically ill patients by using therapeutic drug monitoring -- Quality assurance of samples for therapeutic drug monitoring and clinical toxicology -- Therapeutic drug monitoring and toxicology of anticancer drugs -- Therapeutic drug monitoring and toxicology of immunosuppressant -- Therapeutic drug monitoring and toxicology: relevance of measuring metabolites -- Recent advances in nanosensors for Therapeutic Drug Monitoring (TDM) -- Organ toxicity by immunosuppressive drugs in solid organ transplantation -- Artificial intelligence-based techniques to assess drug toxicity in drug induced liver injury (DILI) disease -- Drug dose and therapy individualization -- Models for drug individualization: patient to population level -- Toxicity evaluation of nanomedicine -- Biochemical indices of drug toxicity -- Therapeutic drug monitoring and clinical toxicology: challenges and future directions.

Description / Table of Contents: Intracellular TLRs (TLR3, TLR7, and TRL9) in host defense or TLRs in mast cells -- Toll-like receptors as drug targets in the intestinal epithelium -- Innate immune memory-priming, tolerance and exhaustion-in health and disease -- TLRs in brain immunity -- TLRs in cerebrovascular diseases -- TLRs in stem cells or progenitor cells -- TLRs in adaptive immunity -- Overview on TLRs in immunity -- TLR10 and its role in immunity.

Description / Table of Contents: Review of the Pathophysiology of the Alloimmune response -- A Comprehensive Review of Calcineurin Inhibitors Used for Immunosuppression in Cardiac Transplantation -- Anti-proliferative Agents -- Mechanistic Target of Rapamycin (mTOR) Inhibitors -- Corticosteroids -- Induction therapy and antibodies -- Immunosuppression and Heart Transplantation -- Immunosuppression and Lung Transplantation -- Immunosuppression and renal transplant recipients -- Immunosuppression in Rheumatologic and Auto-immune Disease -- Immunosuppression in Bone Marrow Transplantation -- Immunosuppression in Multiple Sclerosis and Other Neurologic Disorders -- Novel immunosuppressive agents for the treatment of organ transplants -- Adverse Effects of Immunosuppression: Infections -- Malignancy: An Adverse Effect of Immunosuppression -- Adverse Effects of Immunosuppression:Nephrotoxicity, Hypertension and Metabolic Disease.

Description / Table of Contents: Part I Obesity. Epidemiology of Obesity -- The Circadian Clock and Obesity -- Nutrition and Microbiome -- From Obesity to Diabetes: The Role of the Adipose Organ -- Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy -- The Enteroendocrine System in Obesity -- Insights from Studies of White Adipose Tissue Using Single-Cell Approaches -- Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction -- Obesity, Senescence, and Senolytics -- Obesity and Obstructive Sleep Apnea -- Part II Diabetes and Complications. Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance -- Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes -- NAFLD and NASH: The Metabolically Diseased Liver -- Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities -- Diabetic Peripheral Neuropathy -- Part III Lifestyle Modifications and Future Treatments. Weight Loss Strategies -- Physical Activity, Obesity and Weight Loss Maintenance -- Bariatric/Metabolic Surgery -- Drugs for Treating Obesity -- Novel Drugs for Diabetes Therapy -- Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function -- Precision Medicine and Obesity -- Targeting the Enteroendocrine System for Treatment of Obesity.

Description / Table of Contents: From the contents. Preface.-Part I: Molecular aspects of KOR -- Part II: Preclinical research on pharmacology of KOR agonists and antagonists in animals -- Part III: KOR agonists and antagonists in clinical use and in past and present clinical trials.

Description / Table of Contents: Experimental evidence for pesticide contribution in the pathogenesis of Parkinsonism: an update -- Epidemiological evidence for pesticide involvement in the etiology of Parkinson’s Disease: current state of affairs?” -- Manganese induced Parkinsonism: cellular and molecular mechanisms -- Manganese overexposures in occupational and environmental settings and Parkinsonism: where do we stand -- Aberrant dopamine metabolism as a focal point in the mechanism of environmental contaminant-induced dopaminergic dysfunction -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Protein kinase C-delta (PKC-delta): a major molecular target for disparate dopaminergic toxicants -- Environmental contribution to redox dyshomeostasis in Parkinsonism.

Description / Table of Contents: Chapter 1: Achillea biebersteinii Afan -- Chapter 2: Aesculus hippocastanum L. -- Chapter 3: Berberis crataegina DC. -- Chapter 4: Calendula officinalis L. -- Chapter 5: Camellia sinensis (L.) Kuntze -- Chapter 6: Capsella bursa-pastoris (L.) Medik. -- Chapter 7: Capsicum annuum L. -- Chapter 8: Cedrus libani A.Rich. -- Chapter 9: Chelidonium majus L. -- Chapter 10: Cichorium intybus L. -- Chapter 11: Cistus laurifolius L. -- Chapter 12: Coriandrum sativum L. -- Chapter 13: Cornus mas L. -- Chapter 14: Curcuma longa L..-Chapter 15: Cydonia oblonga Mill. -- Chapter 16: Cynara scolymus L. -- Chapter 17: Equisetum arvense L. -- Chapter 18: Foeniculum vulgare Mill. -- Chapter 19: Fraxiınus ornus L. -- Chapter 20: Fumaria officinalis L. -- Chapter 21: Helichrysum plicatum DC. -- Chapter 22: Hyoscyamus niger L. -- Chapter 23: Juglans regia L. -- Chapter 24: Laurus nobilis L. -- Chapter 25: Liquidambar orientalis Miller -- Chapter 26: Matricaria chamomilla L. -- Chapter 27: Melissa officinalis L. -- Chapter 28: Momordica charantia L. -- Chapter 29: Nigella sativa L. -- Chapter 30: Olea europaea L. -- Chapter 31: Papaver somniferum L. -- Chapter 32: Rheum ribes L. -- Chapter 33: Rosa canina L. -- Chapter 34: Rosmarinus officinalis L. -- Chapter 35: Silybum marianum L. Gaertn. -- Chapter 36: Urtica dioica L -- Chapter 37: Valeriana officinalis L. -- Chapter 38: Viburnum opulus L.

Description / Table of Contents: Part I: Conceptualizing human-nature interactions -- Chapter 1. Conceptualizing human-nature interactions – an overview -- Chapter 2. Environmental Values and Nature’s Contributions to People: Towards methodological pluralism in evaluation of sustainable ecosystem services -- Chapter 3. Disentangling trade-offs between the state of coastal ecosystems with human well-being and activities as a strategy addressing sustainable tourism -- Chapter 4. From human-nature dualism towards more integration in socio-ecosystems studies -- Chapter 5. A network approach to Green Infrastructure: how to enhance ecosystem services provision? -- Chapter 6. Transformations of urban coastal nature(s): Meanings and paradoxes of Blue Urbanism and nature-based solutions for climate adaptation in Southeast Asia -- Part II: Mountain systems -- Chapter 7. Values of mountain landscapes: Insights about the Blue Mountains National Park, Australia from Twitter -- Chapter 8. Earth observations of human-nature interactions from a cultural ecosystem service perspective -- Chapter 9. Gendered Values, Roles, and Challenges for Sustainable Provision of Forest-based Ecosystem Services in Nepal -- Chapter 10. Environmental [in]equity: Accessibility to green spaces in a rapidly urbanizing mountain-city -- Chapter 11. Ecosystem services and sustainable development in the European Alps: spatial patterns and mountain-lowland relationships -- Chapter 12. Human-nature relationships for the Flathead Wild and Scenic River System: Analyzing diversity, synergies, and tensions in a mountainous region of Montana, USA -- Chapter 13. Resilience and sustainability of the Maloti-Drakensberg mountain system: a case study on the upper uThukela catchment -- Chapter 14. Invasive alien plants in the montane areas of South Africa: impacts and management options -- Part III: Urban systems -- Chapter 15. Ecosystem service flows across the rural-urban spectrum -- Chapter 16. A typology for green infrastructure planning to enhance multifunctionality incorporating peri-urban agricultural land -- Chapter 17. Urban green spaces in a post-apartheid city: challenges and opportunities for nature-based solutions -- Chapter 18. Green infrastructure and ecosystem services within spatial structure of city – examples from Poznań, Poland -- Chapter 19. Accessibility to and fragmentation of urban green infrastructure: importance for adaptation to climate change -- Chapter 20. Social Demand for Urban Wilderness in Purgatory -- Chapter 21. The Role of Allotment Gardens for Connecting Nature and People -- Chapter 22. Green spaces and their social functions: specific challenges in urban spaces of arrival -- Chapter 23. The link between urban green space planning tools and distributive, procedural and recognition justice -- Part IV: Coastal-marine systems -- Chapter 24. Can local knowledge of Small-scale fishers be used to monitor and assess changes in marine ecosystems in a European context? -- Chapter 25. Marine ecological democracy: participatory marine planning in Indigenous marine areas in Chile -- Chapter 26. The Socio-Ecological Dimension of Ocean Multi-Use -- Chapter 27. Localizing the Sustainable Development Goals for marine and coastal management in Norway: A venture overdue -- Chapter 28. Coastal-Marine ecosystem accounting to support Integrated Coastal Zone Management -- Chapter 29. Exposure of coastal ecosystem services to natural hazards in the Bangladesh coast -- Chapter 30. Adaptations to climate variability in fisheries and aquaculture social-ecological systems in the Northern Humboldt Current Ecosystem: challenges and solutions -- Chapter 31. Socio-Ecological transformations in coastal wetlands: an approach from the south-central zone of Chile -- Chapter 32. A Nature-based Solution for coastal foredune restoration: The Case Study of Maghery, County Donegal, Ireland.

Description / Table of Contents: C ontents -- Part 1. Theory -- To Understand Economics, Follow the Money: To Understand Ecosystems, Follow the Energy -- Two Views of Ecology, Evolution, and Conservation -- Why I Wrote this Book -- Dualities Still Impede Conservation Efforts -- The Intergovernmental Science-Policy Platform of Biodiversity -- Targets for Conservation -- Evolving Objectives -- Literature Review -- Updating Ecosystem Ecology -- References -- What Can We Learn by Studying Ecosystems that We Can’t Learn from Studying Populations? -- The Predator-Prey Conundrum -- The Serengeti Ecosystem -- Evolution in the “Ecological Theater” -- Predator-Prey Interactions Tell Only Part of the Story -- Evolution in the “Thermodynamic Theater” -- References -- A Thermodynamic Definition of Ecosystems -- Ecosystems in the 20th Century -- Cycling of Strontium-90 -- Cesium-137 in Food Chains -- Recycling of Isotopes in Norwegian Sheep -- Ecological Energetics -- Is it Time to Bury the Ecosystem Concept? -- A Thermodynamic Definition of Life -- A Thermodynamic Definition of Ecosystems -- The Phase Transition between Order and Chaos -- References -- Thermodynamic Characteristics of Ecosystems -- Equilibrium -- The Equilibrium Law -- Thermodynamic Equilibrium -- Open Thermodynamic Systems -- Ecosystems are Thermodynamically Open Non-Equilibrium Systems -- Work is Performed by Non-equilibrium Systems -- Advantage of a Thermodynamically Open System -- 4.3 Ecosystems are Entropic -- 4.4 Ecosystems are Cybernetic -- Cybernetic Systems -- Economic Systems are Cybernetic Ecosystems are Cybernetic -- The Ecosystem Feedback Function -- Indirect vs. Direct Feedback -- Deviation Dampening and Amplifying Feedback -- Set Points -- Ecosystems are Autocatalytic -- Ecosystems have Boundaries -- Ecosystems are Hierarchical -- Hierarchy in Physical Systems -- Hierarchy in Ecological Systems -- Common Currencies -- Macro-and Micro-System Models -- Why an Ecosystem Model that Includes Everything is not Possible -- A Nested Marine Community -- Ecosystems are Deterministic -- Ecosystems are Information Rich -- An Engineering Definition of Information -- Information to Facilitate Exchange -- High Energy Information -- Low Energy Information -- Information Theory -- Genetic Information -- Ecosystems are Non-Teleological -- Criticisms of Ecosystem Models -- References -- Ecosystem Control: A Top-Down View -- Two Ways to Look at Systems -- Composing and Decomposing Trophic Webs -- Decomposers in Soil Organic Matter -- Decomposers in Marshes and Mangroves -- Control of Systems -- Top-Down vs. Bottom-Up -- Top-Down Exogenous Control -- Exogenous Impacts and Stability -- Top-Down Endogenous Control -- Endogenous Control through Nutrient Recycling -- Autocatalysis -- Control of Microbial Activity -- Inhibition of Microbial Activity by Leaf Sclerophylly -- Inhibition of Microbial Activity Chemical Defenses -- Inhibition of Microbial Activity by Ecological Stoichiometry -- The Synchrony Principle -- The Decay Law -- Direct Nutrient Cycling -- The Role of Animals -- Indirect Interactions -- Marine Systems -- Nutrient and Energy Recycling -- Exogenous Control -- Control in Lakes -- Control in Managed Ecosystems -- References -- Ecosystem Control: A Bottom-Up View -- Species as Arbitrageurs of Energy -- Relation Between Rate of Flow and Mass in Hydraulic Systems -- Relation Between Population Biomass and Rate of Energy Flow -- Equilibrium -- Mechanisms of Adjustment -- Adjustments and Climate Change -- Bird Populations -- Dis-equilibrium -- Population Instability vs. Ecosystem Instability -- Control by Interactions: Direct vs. Indirect -- Indirect Interactions -- Direct Interactions -- Predator – Prey -- Mutualisms -- Competition -- Decomposition -- Parasitism and Disease -- Commensalism and Amensalism -- Persistence of Negative Interactions -- References -- Ecosystem Stability -- Background -- A Thermodynamic Definition -- Regime Shift -- Metastability -- Pulsed Stability -- Resistance and Resilience -- Species Richness and Functional Stability -- Species Richness and Cultural Values -- Keystone Species, and Population and Ecosystem Stability -- 7.5.1 Keystone Species in the Yellowstone region of Wyoming -- References -- 8. Case Studies of Ecosystem Control and Stability -- Walden -- “Harmony in Nature” -- Feedback Produces Nature’s “Harmony” -- Feedback Mechanisms -- Perturbations in Amazon Rain Forests -- Top-Down Control -- The San Carlos Project: A Small-scale, Low Intensity, Short Duration Disturbance -- 8.3.2 The Jarí Project: A Large-scale, High Intensity, Long Duration Disturbance -- Bottom-Up Control -- The El Verde Project -- The Long-Term Ecological Research Project in Puerto Rico -- The Lago Guri Island Project -- The Biological Dynamics of Tropical Rainforest Fragments Project -- What have Case Studies Taught us about Stability of Tropical Ecosystems? -- Tropical Ecosystems are Stable -- Tropical Ecosystems are Unstable -- Energy Flow in Tropical Savannas and Rain Forests -- Insects in Tropical Ecosystems -- Application of Lessons to Other Regions -- Relevance to Temperate Zones -- Relevance to Aquatic Ecosystems -- The Experimental Lakes Project (Ecosystem Control of Species) -- Lake Mendota Studies (Species Control of Ecosystems) -- 8.7 Case Studies as Tests of Thermodynamic Theory -- References -- Entropy and Maximum Power -- Entropy -- 9.2 Entropy in a Steel Bar -- Thermodynamic Equilibrium -- Entropic Gradients -- Capturing and Storing Entropy -- Evapotranspiration and Entropy Reduction -- Life is a Balance between Storing and Releasing Entropy -- The Law of Maximum Entropy Production -- Energy for Metabolism as well as Growth -- Unassisted Entropy Capture is a Unique Characteristic of Life.-9.6Entropy Storage by Ecosystems -- 9.6.1 What Causes Entropy to be Stored? -- 9.7 Capturing Pressure -- 9.8 Entropy and Time -- 9.8.1 Time’s Speed Regulator -- Efficiency of Energy Transformations -- Passage of Time for Cats -- 9.9The Maximum Power Principle.-9.10 Optimum Efficiencies for a Truck and its Driver.-9.11 Sustainability -- References -- A Thermodynamic View of Succession -- 10.1 The Population View -- 10.2 The Thermodynamic View -- 10.2.1 Leaf Area Index and Succession -- 10.2.2 Power Output as a Function of Leaf Area Index -- 10.2.3 What Causes Changes in Leaf Area Index? -- 10.2.4 Maximum Entropy Production Principle -- 10.2.5 Successional Ecosystems Move Further from Thermodynamic Equilibrium -- 10.2.6 Entropy Storage by Animals -- 10.3 The Strategy of Ecosystem Development -- A Problem with Odum’s Strategy -- Why Power Output Continues to Increase -- Revised Definition of Maximum Power -- Costs of Ecosystem Stabilization -- Transactional Costs -- Succession, Power Output, and Efficiency -- 10.5.1 Kleiber’s Law -- Are Ecosystems Spendthrifts? -- Interactions Between Species Facilitate Increase in Power Output -- Facilitation -- Tolerance -- Inhibition -- Intermediate Disturbance Hypothesis -- Nutrient Use Efficiency during Succession -- Succession Following Logging vs Following Agriculture -- 10.10 Thermodynamic View of Succession: Implications for Resource Management -- References -- Panarchy -- The Universal Cycle of Systems -- Panarchy -- Thermodynamic Interpretation of the Sacred Rules -- 11.2.1 Growth and Consolidation -- 11.2.2 Collapse -- Renewal -- Sub-systems -- Panarchy over 2 Billion Years of Evolution -- Consolidation, Bureaucracy and System Collapse -- Bureaucracy in Action (Case Studies) -- Case Study: Panarchy in the Georgia Piedmont -- Thermodynamic Interpretation -- References -- 12. A Thermodynamic View of Evolution -- 12.1 Life – A Physicist's View -- 12.1.1 Life is Produced by Capturing Entropy -- 12.1.2 The Origin of Life -- 12.2 Two Approaches to Evolution -- 12.2.1 The Eco-Evo-Devo View -- 12.2.2 The Thermodynamic View -- 12.2.3 Fitness -- 12.2.4 The “Goal” of Evolution -- 12.3 The Relationship between Species and Environment -- 12.3.1 Evolution’s “Theater” -- 12.3.2 Is Evolution Stochastic or Deterministic? -- 12.4 Ecosystem Evolution -- 12.4.1 Succession was the Clue -- 12.4.2 Ecosystems Moved away from Equilibrium -- 12.4.3 Thermodynamic Mechanisms -- 12.4.4 Biological Mechanisms -- 12.4.5 Ecosystem Fitness -- 12.4.6 Ecosystems Evolve One Step at a Time -- 12.5. The Origin of Ecosystems -- 12.5.1 Origin of Feedback Loops -- 12.5.2 Origin of Trophic Levels -- 12.5.3 Why are there Trophic Levels? -- 12.6 The “Goal” of Ecosystem Evolution -- 12.6.1 Conflicting Goals? -- 12.6.2 “Motivations” of Species -- 12.6.3 The Earth Ecosystem -- 12.6.4 Why is there Resistance to the Idea of Ecosystem Evolution? -- 12.6.5 Evolution of Economic Systems -- 12.7 A Thermodynamic Model of Ecosystem Evolution -- 12.7.1 Network Models -- 12.7.2 Increase in Complexity of Trophic Webs -- 12.7.3 Evolution of Trophic Webs -- 12.7.4 Life Moves Ashore -- 12.8 Biodiversity and the Five Great Extinctions -- 12.8.1 The Cretaceous-Tertiary (K-T) Boundary Extinction -- 12.8.2The Amazing Sustainability of Trophic Chains -- 12.8.3 A Test of Thermodynamic Theory -- 12.9 Panarchy and Evolution -- 12.10 Thermodynamic Requirements for Living Systems on Other Planets -- References -- -- Why is Species Diversity Higher in the Tropics? -- 13.1 Tropical Explorations -- 13.2 A Few Theories -- 13.3 A Thermodynamic Explanation -- 13.3.1 The Latitudinal Energy Gradient -- 13.3.2 The Latitudinal Productivity Gradient -- 13.3.3 The Data -- 13.3.4 Other Factors Affecting Productivity -- 13.4 Empirical Evidence for a High Productivity High Diversity Correlation -- 13.5 Humboldt’s Enigma -- 13.5.1 Are Productivity and Species Richness Correlated on Tropical -- Mountains? -- 13.6 The Mechanism Linking Productivity and Diversity -- 13.7 Answer to “Why is Species Diversity Higher in the Tropics?” -- 13.7.1 Differences within the Tropics -- 13.8 Why is Species Diversity Low at High Latitudes? -- 13.9 An Economic Perspective on D.

Description / Table of Contents: Introduction: Taxonomy, distribution and conservation status of wild guanaco’s populations -- 1. Zooarchaeological and socio-anthropological perspective of the human - guanaco (Lama guanicoe) interaction over the last 6000 years in the Patagonia, Argentina -- 2. Interspecific competition between guanacos and livestock and its impact on Patagonian rangelands: review and synthesis -- 3. Health status of Patagonian guanaco and its relevance for conservation -- 4. Patagonian pumas and their ungulate prey in the 21st century, a key interaction in a degraded environment -- 5. International policies and national legislation concerning guanaco conservation, management and trade in Argentina -- 6. Guanaco sustainable management as a conservation strategy and socioeconomic rural development -- 7. Historical perspective and current advances in ecology, conservation and management of the guanaco in the Chilean Patagonia -- 8. Lessons for the future of conservation and sustainable use of guanacos.

Description / Table of Contents: Part I: About Environmental Education -- Chapter 1 - Training and dissemination about the Environment: keys to impulse the abiotic component of Environmental Education -- Chapter 2 Educating to deliver environmentally focused social innovation -- Chapter 3 - Environmental education for sustainable development: working for fundamental rights -- Chapter 4 - Nature as a teaching resource and the nature of learning -- Part II: Environmental Education and it´s Teaching -- Chapter 5 - The importance of Nature-based solutions to enhance Cabo Verde's Environment -- Chapter 6- Development of Scientific Literacy and the impact of environmental attitudes of citizens in a geological natural space -- Chapter 7- A PBL approach to Environmental Education through a Field Trip and a Science Centre Visit -- Chapter 8- Living labs in higher education: sustainable buildings technologies -- Chapter 9 - What is doing Latin America regarding the teaching of Nature-based solutions to boost Environmental Education? -- Chapter 10 - Lessons learned from including aquaponic experiments into five different tertiary education curricula -- Chapter 11 - Recommendations for promoting Environmental Education through Nature-based solutions at Turkish Higher Education Institutes -- Part III: Environmental Education and Social Engagement -- Chapter 12 - Bees and Society: native biodiversity as a strategy for environmental education based on the processes of nature -- Chapter 13- Perceptions about Sustainable Development of visitants in an Environmental Education Natural Park -- Chapter 14 - Start Park project: co-designing green-blue infrastructures to build resilient communities to climate change -- Chapter 15 - Societal embedding in geoparks: a case study in Portugal -- Chapter 16 - Environmental Education in Naturtejo UNESCO Global Geopark (Portugal): a nature-based approach -- Part IV: – Environmental Education and Nature-Based Solutions -- Chapter 17- Green Roof and walls technology standardisation and market across Europe -- Chapter 18- How Nature-Based Solutions can Contribute to Enhance Circularity in Cities -- Chapter 19- Nature-based solutions to promote environmental education on integral ecological sanitation -- Chapter 20 - Nature-based solutions for environmental education in the East Asian context -- Chapter 21- Decarbonizing the European energy sector: frameworks, examples and how education plays a key role -- Chapter 22- Nature-based solutions for water pollution control: promoting environmental education through case studies.

Description / Table of Contents: Drying -- Mixing -- Comminution -- Filtration -- Pharmaceutical Packaging -- Oral Emulsion -- Oral Suspensions -- Tablets and Capsules -- Oral Inhalers -- Topically Applied Products -- Sterile Products -- Industrial Hazards -- Modified Release Drug Delivery Systems -- Novel Drug Delivery System -- Polymer for Biomedical Applications -- Biotechnology Based Drugs.

Description / Table of Contents: Part I. Social aspects of opioid use -- Chapter 1: A brief history of opioids and the evolution of concepts associated with substance use disorders -- Chapter 2: The two sides of opioid use: Unmet needs of opioids for pain management and the role of opioids in substance use disorders -- Chapter 3: Opioid markets and special populations -- Chapter 4: Towards a new drug policy agreement -- Chapter 5: The opioid crises -- Chapter 6: Persons who misuse opioids -- Chapter 7: The need for structural interventions for persons who misuse opioids -- Part II. Pharmacological and medical aspects of opioid use -- Chapter 8: Opioid effects and classification -- Chapter 9: Opioid receptors and neuronal signal transduction -- Chapter 10: Opioids in Pain -- Chapter 11: Opioids in Palliative Care -- Chapter 12: Opioids and the immune system -- Chapter 13: Opioid dependence, tolerance, and withdrawal -- Chapter 14: Medication-Assisted Treatment (MAT) 1: Opioid substitution therapy -- Chapter 15: Medication-Assisted Treatment for Opioid Use Disorders 2. Detoxification -- Chapter 16: Synthetic Opioids as New Psychoactive Substances (NPS).

Description / Table of Contents: From the contents: Preface -- Part I: Background on the Blood Brain Barrier – structure/function.-Part II: Challenges with finding drugs to cross the BBB/not cross BBB -- Part III: Experimental Methods to study BBB – in vitro and in vivo -- Part IV: BBB and Diseases: Novel treatment approaches from a BBB perspective. .

Description / Table of Contents: Drug discovery paradigms: target-based drug discovery -- Drug discovery paradigms: phenotypic-based drug discovery -- Target Identification Approaches in Drug Discovery -- Introduction to target validation -- Structure-based binding pocket detection and druggability assessment -- Network-Based Target Identification -- The Current State of Precision Medicine and Targeted-Cancer Therapies – Where are We? -- Metabolic Control Analysis for drug target selection against human diseases -- Progress on open chemoinformatic tools for drug discovery.

Description / Table of Contents: Preface -- Part I: History and Epidemiology -- Part II: General Mechanisms -- Part III: Symptoms and Diseases -- Part IV: From Environmental Trigger to Disease Management -- Part V: Specific Mechanisms -- Part VI: Risk Factors -- Part VII: Diagnostics -- Part VIII: Allergy Prevention.

Description / Table of Contents: Section I: General, Identity and Taxonomy -- The genus Phoma: What we know and what we need to know? -- Taxonomical evaluation of Phoma- history of classification, current status and future directions -- Section II: Diversity, Diseases and Host Range -- Phoma on medicinal and aromatic plants -- Diseases of fruits, tubers, and seeds caused by Phoma sensu lato species complex -- Overview of Phoma-like fungi on important legumes (Papilionaceous plants) -- Diseases of vegetables caused by Phoma spp -- Phoma diseases: identification, epidemiology and strategies for management -- Major plant diseases caused by Phoma sensu lato species and their integrated management strategies -- Phoma as an infectious pathogen in medical practice -- Section III: Secondary metabolites and Bioactivities -- Fruitful decade of Phoma secondary metabolites from 2011 to 2020: Chemistry, chemical diversity and biological activities -- Bioactive secondary metabolites from endophytic Phoma spp -- The genus Phoma: a review of its potential bioactivities, implications and prospects -- Bioherbicidal activity of Phoma macrostoma -- New technologies for the formulation of secondary metabolites produced by Phoma sp. for biological control of weeds -- Biological management of plant diseases by non-pathogenic Phoma spp -- Plant growth promoting Phoma spp -- Section IV:Nanotechnology and Fossil records of Phoma -- Potential role of Phoma spp. for mycogenic synthesis of Silver nanoparticles -- In situ occurrence of Phomites Fritel in the phyllosphere of ancient Siwalik forests of eastern Himalaya during the Mio-Pleistocene.

Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.

Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.

Description / Table of Contents: PRELIMINARY (ToC of second edition) 1 Plant ecology at high elevations -- The concept of limitation -- A regional and historical account -- The challenge of alpine plant research -- 2 The alpine life zone -- Altitudinal boundaries -- Global alpine land area -- Alpine plant diversity -- Origin of alpine floras -- Alpine growth forms -- 3 Alpine climate -- Which alpine climate -- Common features of alpine climates -- Regional features of alpine climates -- 4 The climate plants experience -- Interactions of relief, wind and sun -- How alpine plants influence their climate -- The geographic variation of alpine climate -- 5 Life under snow: protection and limitation -- Temperatures under snow -- Solar radiation under snow -- Gas concentrations under snow -- Plant responses to snowpack -- 6 Alpine soils -- Physics of alpine soil formation -- The organic compound -- The interaction of organic and inorganic compounds -- 7 Alpine treelines -- About trees and lines -- Current altitudinal positions of climatic treelines -- Treeline-climate relationships -- Intrazonal variations and pantropical plateauing of alpine treelines -- Treelines in the past -- Attempts at a functional explanation of treelines -- A hypothesis for treeline formation -- Growth trends near treelines -- Evidence for sink limitation -- 8 Climatic stress -- Survival of low temperature extremes -- Avoidance and tolerance of low temperature extremes -- Heat stress in alpine plants -- Ultraviolet radiation — a stress factor -- 9 Water relations -- Ecosystem water balance -- Soil moisture at high altitudes -- Plant water relations — a brief review of principles -- Water relations of alpine plants -- Desiccation stress -- Water relations of special plant types -- 10 Mineral nutrition -- Soil nutrients -- The nutrient status of alpine plants -- Nutrient cycling and nutrient budgets -- Nitrogen fixation -- Mycorrhiza -- Responses of vegetation to variable nutrient supply -- 11 Uptake and loss of carbon -- Photosynthetic capacity of alpine plants -- Photosynthetic responses to the environment -- Daily carbon gain of leaves -- The seasonal carbon gain of leaves -- C4 and CAM photosynthesis at high altitudes -- Tissue respiration of alpine plants -- Ecosystem carbon balance -- 12 Carbon investments -- Non-structural carbohydrates -- Lipids and energy content -- Carbon costs of leaves and roots -- Whole plant carbon allocation -- 13 Growth dynamics and phenology -- Seasonal growth -- Diurnal leaf extension -- Rates of plant dry matter accumulation -- Functional duration of leaves and roots -- 14 Cell division and tissue formation -- Cell size and plant size -- Mitosis and the cell cycle -- From meristem activity to growth control -- 15 Plant biomass production -- The structure of alpine plant canopies -- Primary productivity of alpine vegetation -- Plant dry matter pools -- Biomass losses through herbivores -- 16 Plant reproduction -- Flowering and pollination -- Seed development and seed size -- Germination -- Alpine seed banks and natural recruitment -- Clonal propagation -- Alpine plant age -- Community processes -- 17 Global change at high elevation -- Alpine land use -- The impact of altered atmospheric chemistry -- Climatic change and alpine ecosystems -- References (with chapter annotation) -- Taxonomic index (genera) -- Geographical index -- Color plates -- Plant life forms -- The alpine life zone -- Environmental stress -- The human dimension.

Description / Table of Contents: Part 1: Historical and biogeographical aspects -- The Atlantic Forest: an introduction to the megadiverse forest of Southern America -- The Atlantic Forest Ecological History: from pre-history to the Anthropocene -- The North-eastern Atlantic Forest: biogeographical, historical and current aspects in the Sugarcane Zone -- The Hileia Baiana - an assessment of natural and historical aspects of the land use and degradation of the central corridor of the Brazilian Atlantic Forest -- The southern Atlantic Forest: Use, degradation, and perspectives for conservation -- Part II – Biodiversity -- Tree diversity in the Brazilian Atlantic Forest: biases and general patterns using different sources of information -- Vascular Epiphytes of the Atlantic Forest: diversity and community ecology -- Social Insects of the Atlantic Forest -- Tetrapod diversity in the Atlantic Forest: maps and gaps -- Freshwater Studies in Atlantic Forest: general overview and prospects -- Part III – Threats -- Land-cover changes and an uncertain future: will the Brazilian Atlantic Forest lose the chance to become a hopespot? -- Climate change and biodiversity in the Atlantic Forest: best climatic models, predicted changes and impacts, and adaptation options -- Non-native species introductions, invasions, and biotic homogenization in the Atlantic Forest -- Causes and consequences of large-scale defaunation in the Atlantic forest -- Pollination systems in the Atlantic Forest: characterization, threats, and opportunities -- IV - Opportunities -- Atlantic Forest: ecosystem services linking people and biodiversity -- Changing the agriculture paradigm in the Brazilian Atlantic Forest: the importance of agroforestry -- Engaging people for large-scale forest restoration: Governance lessons from the Atlantic Forest of Brazil -- The Atlantic Forest Trail: connecting people, biodiversity and protected areas -- Conservation initiatives in the Brazilian Atlantic forest -- Financing conservation in the Brazilian Atlantic Forest -- Integrating researchers for understanding the biodiversity in Atlantic Forest -- The future of the Atlantic Forest.

Description / Table of Contents: Comparison of K+ Channel families -- High-resolution structures of K+ channels -- Pharmacological approaches to studying potassium channels -- Cardiac K+ channels and channelopathies -- Cardiac hERG K+ channel as safety and pharmacological target -- Pharmacology of A-type K+ channels -- Kv7 channels and hyperexcitability disorders -- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain -- Potassium channels in cancer -- Kir channel molecular physiology, pharmacology and therapeutic implications -- The pharmacology of ATP-sensitive K+ channels (KATP) -- Calcium-activated K+ channels (KCa) and therapeutic implications -- The Pharmacology of two-pore domain potassium channels -- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits -- Peptide toxins targeting KV channels -- Therapeutic antibodies targeting potassium ion channels.

Description / Table of Contents: Chapter 1. Introduction (Deborah C. Hayes, Becky K. Kerns, Toral Patel-Weynand, and Deborah M. Finch) -- Chapter 2. Impacts of Invasive Species in Terrestrial and Aquatic Systems in the United States (Albert E. Mayfield III, Steven J. Seybold, Wendell R. Haag, M. Tracy Johnson, Becky K. Kerns, John C. Kilgo, Daniel J. Larkin, Rima D. Lucardi, Bruce D. Moltzan, Dean E. Pearson, John D. Rothlisberger, Jeffrey D. Schardt, Michael K. Schwartz, and Michael K. Young) -- Chapter 3. Impacts of Invasive Species on Forest and Grassland Ecosystem Processes in the United States (Chelcy Ford Miniat, Jennifer M. Fraterrigo, Steven T. Brantley, Mac A. Callaham, Jr., Susan Cordell, Jeffrey S. Dukes, Christian P. Giardina, Shibu Jose, and Gary Lovett) -- Chapter 4. Effects of Climate Change on Invasive Species (Deborah M. Finch, Jack L. Butler, Justin B. Runyon, Christopher J. Fettig, Francis F. Kilkenny, Shibu Jose, Susan J. Frankel, Samuel A. Cushman, Richard C. Cobb, Jeffrey S. Dukes, Jeffrey A. Hicke, and Sybill K. Amelon) -- Chapter 5. Invasive Species Response to Natural and Anthropogenic Disturbance (Susan E. Meyer, Mac A. Callaham, Jr., Jane E. Stewart, and Steven D. Warren) -- Chapter 6. Early Intervention Strategies for Invasive Species Management: Connections Between Risk Assessment, Prevention Efforts, Eradication, and Other Rapid Responses (Robert C. Venette, Doria R. Gordon, Jennifer Juzwik, Frank H. Koch, Andrew M. Liebhold, Robert K.D. Peterson, Sharlene E. Sing, and Denys Yemshanov) -- Chapter 7. Management of Landscapes for Established Invasive Species (Therese M. Poland, Jennifer Juzwik, Allen Rowley, Cynthia D. Huebner, John C. Kilgo, Vanessa M. Lopez, Deanna H. Olson, Dean Pearson, Robert Progar, Robert Rabaglia, John D. Rothlisberger, Justin B. Runyon, and Sharlene E. Sing) -- Chapter 8. Restoration of Landscapes and Habitats Affected by Established Invasive Species (Jennifer Koch, Dean E. Pearson, Cynthia D. Huebner, Michael K. Young, and Richard A. Sniezko) -- Chapter 9. Sectoral Impacts of Invasive Species in the United States and Approaches to Management (Anne S. Marsh, Deborah C. Hayes, Patrice N. Klein, Nicole Zimmerman, Alison Dalsimer, Douglas A. Burkett, Cynthia D. Huebner, Robert Rabaglia, Laura A. Meyerson, Bonnie L. Harper-Lore, Jamie L. Davidson, Marla R. Emery, Travis Warziniack, Rebecca Flitcroft, Becky K. Kerns, and Vanessa M. Lopez) -- Chapter 10. Inventory and Monitoring of Invasive Species (Sonja Oswalt, Chris Oswalt, Alycia Crall, Robert Rabaglia, Michael Schwartz, and Becky K. Kerns) -- Chapter 11. Tools and Technologies for Quantifying Spread and Impacts of Invasive Species (Matt Reeves, Inés Ibáñez, Dana Blumenthal, Gang Chen, Qinfeng Guo, Catherine Jarnevich, Jennifer Koch, Frank Sapio, Michael K. Schwartz, Bruce K. Wylie, and Stephen Boyte) -- Chapter 12. Social and Cultural Dynamics of Non-Native Invasive Species (John Schelhas, Janice Alexander, Mark Brunson, Tommy Cabe, Alycia Crall, Michael J. Dockry, Marla R. Emery, Susan J. Frankel, Nina Hapner, Caleb R. Hickman, Rebecca Jordan, Michael J. LaVoie, Zhao Ma, Ross K. Meentemeyer, Joe Starinchak, and Jelena Vukomanovic) -- Chapter 13. The Role of International Cooperation in Invasive Species Research (Andrew Liebhold, Faith Campbell, Doria R. Gordon, Qinfeng Guo, Nathan Havill, Bradley Kinder, Richard MacKenzie, David R. Lance, Dean Pearson, Sharlene E. Sing, Travis Warziniack, Robert C. Venette, and Denys Yemshanov) -- Chapter 14. Economics of Invasive Species (Travis Warziniack, Robert G. Haight, Denys Yemshanov, Jenny L. Apriesnig, Thomas P. Holmes, Amanda M. Countryman, John D. Rothlisberger, and Christopher Haberland) -- Chapter 15. Legislation and Policy (Faith T. Campbell, Hilda Diaz-Soltero, and Deborah C. Hayes) -- Chapter 16. Future Invasive Species Research Challenges and Opportunities (Becky K. Kerns, Therese M. Poland, Robert C. Venette, Toral Patel-Weynand, Deborah M. Finch, Allen Rowley, Deborah C. Hayes, Mike Ielmini) -- APPENDIX 1: Regional Summaries.

Description / Table of Contents: Part I. Soil and Sediment Contaminants, Risk Assessment and Remediation -- Chapter 1. Introduction to Part I: Soil and Sediment Contaminants, Risk Assessment and Remediation -- Chapter 2. Combating Arsenic Pollution in Soil Environment via Alternate Agricultural Land Use -- Chapter 3. Temporal and Seasonal Variation in Leachate Pollution Index (LPI) in Sanitary Landfill Sites- A Case study of Baidyabati landfill, West Bengal, India -- Chapter 4.Quantification of Landfill Gas Emission and Energy Recovery Potential: A Comparative Assessment of LandGEM and MTM Model for Kolkata -- Chapter 5. Assessment of natural enrichment of heavy minerals along coastal placers of India: Role of lake and river mouth embayment and its implications -- Chapter 6. Assessment the Impact of Plastic Contaminated Fertilizers on Agricultural Soil Health: A Case Study in Memari II C.D.Block, Purba Bardhaman,West Bengal, India -- Chapter 7. Determining the Role of Leaf Relative Water Content and Soil Cation Exchange Capacity in Phytoextraction Process – Using Regression Modelling -- Chapter 8. Phytoremediation of Arsenic using Allium sativum as Model System -- Chapter 9. Spatio-temporal analysis of open waste dumping sites using Google Earth: A case study of Kharagpur City, India -- Part II. Water Contaminants, Risk Assessment and Remediation -- Chapter 10. Introduction to Part II: Water Contaminants, Risk Assessment and Remediation -- Chapter 11. Groundwater Arsenic Contamination Zone based on geospatial modeling, risk and remediation -- Chapter 12. Geospatial assessment of surface water pollution and industrial activities in Ibadan, Nigeria -- Chapter 13. Aquaculture-based water quality assessment and risk remediationalong the Rasulpur River belt, West Bengal -- Chapter 14. Heavy Metal Contamination in Groundwater and Impact on Plant and Human -- Chapter 15. Emerging Threats of Microplastic contaminant in freshwater environment -- Chapter 16. Exploring Particle Size Transport Variability of Suspended Sediments in two Alpine Catchments over the Lesser Himalayan Region, India -- Chapter 17. Salinity and corrosion potential of groundwater in Mewat district of Haryana, India -- Chapter 18. Threats to quality in the coasts of the Black Sea: heavy metal pollution of seawater, sediment, macro-algae and sea-grass -- Chapter 19. Geospatial assessment of groundwater quality for drinking through Water Quality Index and Human Health Risk Index in an upland area of Chotanagpur Plateau of West Bengal, India -- Chapter 20. Existence of Pharmaceuticals and Personal Care Products (PPCPs) in the conventional water treatment process -- Chapter 21. Arsenic-rich surface and groundwater around eastern parts of Rupnagar district, Punjab, India -- Part III. Environmental Contaminants, Impacts and Sustainable Management -- Chapter 22. Introduction to Part III: Environmental Contaminants, Risk Assessment and Remediation -- Chapter 23. Dynamics of ultra-fine particles in indoor and outdoor environments: a modelling approach to study the evolution of particle characteristics -- Chapter 24. Environmental impacts of coal-mining and coal-fired power-plant activities in a developing country with global context -- Chapter 25. Overview of Indoor air pollution: A human health perspective -- Chapter 26. Mineralogy and Morphological characterization of Technogenic Magnetic Particles (TMP) from industrial dust: Insights into environmental implications -- Chapter 27. Pesticides: Recent Updates on Types Toxicity and Bioremediation Strategies -- Chapter 28. Commonly available plant neem (Azadirachtaindica A. Juss) ameliorates dimethoate induced toxicity in climbing perch Anabas testudineus -- Chapter 29. Estimating Particulate Matter concentrations from MODIS AOD considering meteorological parameters using Random Forest Algorithm -- Chapter 30 Bio-monitoring and bioremediation of a trans-boundary river in India: Functional roles of benthic mollusks and fungi -- Chapter 31 Assessing the Maximum Aerobic Biodegradation Potential of Leaf Litter, an Organic Fraction of Municipal Solid Waste, Under Optimum Nutrient Conditions -- Chapter 32. Rising trend of air pollution and its decadal consequences on meteorology and thermal comfort over Gangetic West Bengal, India.

Description / Table of Contents: Chapter 1. Introduction to Fire Ecology across USA Forested Ecosystems: Past, Present, and Future (Cathryn H. Greenberg, Beverly S. Collins, Scott Goodrick, Michael C. Stambaugh, and Gary R. Wein) -- Chapter 2. The Role of Fire in the Dynamics of Piedmont Vegetation (Joanna Spooner, Robert K. Peet, Michael P. Schafale, Alan S. Weakley and Thomas R. Wentworth) -- Chapter 3. Fire Ecology and Fire Management of Southeastern Coastal Plain Pine Ecosystems (Jeff S. Glitzenstein, J. Stephen Brewer, Ronald. E. Masters, J. Morgan Varner, and J. Kevin Hiers) -- Chapter 4. Fire Ecology and Management in Eastern Broadleaf and Appalachian Forests (Mary A. Arthur, J. Morgan Varner, Charles W. Lafon, Heather D. Alexander, Daniel C. Dey, Craig A. Harper, Sally P. Horn, Todd F. Hutchinson, Tara L. Keyser, Marcus A. Lashley, Christopher E. Moorman, and Callie J. Schweitzer) -- Chapter 5. Fire Ecology and Management of Forest Ecosystems in the Western Central Hardwoods and Prairie-Forest Border (Michael C. Stambaugh, Benjamin O. Knapp, and Daniel C. Dey) -- Chapter 6. Fire in Floodplain Forests of the Southeastern USA hy (Paul R. Gagnon, Loretta L. Battaglia, Brice B. Hanberry, William H. Conner, and Sammy L. King) -- Chapter 7. History and Future of Fire in Hardwood and Conifer Forests of the Great Lakes-Northeastern Forest Region, USA(Lee E. Frelich, Craig G. Lorimer, and Michael C. Stambaugh) -- Chapter 8. Fire Ecology of Rocky Mountain Forests(Sharon M. Hood, Brian J. Harvey, Paula J. Fornwalt, Cameron E. Naficy, Winslow D. Hansen, Kimberley T. Davis, Mike A. Battaglia, Camille Stevens-Rumann, Victoria Saab) -- Chapter 9. Fire Ecology of the North American Mediterranean-Climate Zone(Hugh D. Safford, Ramona J. Butz, Gabrielle N. Bohlman, Michelle Coppoletta, Becky L. Estes, Shana E. Gross, Kyle E. Merriam, Marc D. Meyer, Nicole A. Molinari, and Amarina Wuenschel) -- Chapter 10. Fire Ecology and Management in Pacific Northwest Forests(Matthew J. Reilly, Jessica E. Halofsky, Meg A. Krawchuk, Daniel C. Donato, Paul F. Hessburg, James Johnston, Andrew Merschel, Mark E. Swanson, Joshua S. Halofsky, and Thomas A. Spies) -- Chapter 11. Fire Ecology and Management of Southwestern Forests(Peter Z. Fulé, Catrin M. Edgeley, Carol L. Chambers, Serra Hoagland, Blanca Céspedes) -- Chapter 12. Fire and Forests in the 21st Century: Managing Resilience under Changing Climates and Fire Regimes in USA Forests(James M. Vose, David L. Peterson, Christopher J. Fettig, Jessica E. Halofsky, J. Kevin Hiers, Robert E. Keane, Rachel Loehman, and Michael C. Stambaugh).

Description / Table of Contents: General Overview of Organic Cation Transporters in Brain -- Organic Cation Transporter Expression and Function in the CNS -- Genetic and Epigenetic Regulation of Organic Cation Transporters -- Experimental Methods for Investigating Uptake 2 Processes In Vivo -- Substrates and inhibitors of OCTs and PMAT and therapeutic implications -- Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications -- Organic Cation Transporters in Brain Catecholamine Homeostasis -- The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances -- Organic Cation Transporters in Psychiatric Disorders -- Organic Cation Transporters and Nongenomic Glucocorticoid Action -- Brain Plasma Membrane Monoamine Transporter in Health and Disease -- Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications -- Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery.

Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.

Description / Table of Contents: Pharmacological thinking in WNT signaling -- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically -- WNTs on exosomes -- Strategies to target LRPs in WNT signaling -- Targeting the receptor tyrosine kinase ROR1 by small molecules -- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors -- Disheveled proteins as crucial mediators of WNT signaling -- Destruction complex and regulation of CTNNB1 -- Strategies to therapeutically target WNT/PCP like signaling in disease -- Mining natural compounds to target WNT signaling - from mushrooms to corals -- FZD7 as a therapeutic target in intestinal cancer -- Targeting oncogenic WNT signaling with WNT derived peptides -- Targeting WNT signaling in lung pathology -- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting -- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy? -- Targeting WNT signaling as a risk.

Description / Table of Contents: Chapter 1 The World of Carbohydrates -- Chapter 2 Basic Knowledge of Glycobiology -- Chapter 3 Carbohydrates involved in Diseases -- Chapter 4 Detection of Carbohydrate by Colorimetric Methods -- Chapter 5. Analytical Techniques to Study Carbohydrates -- Chapter 6 Monosaccharide Composition Analysis -- Chapter 7 Carbohydrate Analysis of Glycoconjugates -- Chapter 8 Structural Characterization of Released Glycans -- Chapter 9 Analysis of Sialic Acids -- Chapter 10 Carbohydrate Microarray Technology -- Chapter 11 Analysis of Carbohydrates by Mass Spectrometry -- Chapter 12 Analysis of Carbohydrates by Nuclear Magnetic -- Chapter 13 Glycobioinformatics -- Chapter 14 Concluding Remarks. .

Description / Table of Contents: Part 1 Introduction -- 1 Host Community Interfaces: The Wildlife-Livestock -- 2 Natural And Historical Overview Of The Animal Wildlife-Livestock Interface -- 3 The Ecology Of Pathogens Transmission At The Wildlife-Livestock Interface: Beyond Disease Ecology, Towards Socio-Ecological System Health -- Part 2 Regional Perspectives Of Disease At The Wildlife-Livestock Interface -- 4 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Europe -- 5 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Asia -- 6 Characteristics And Perspectives Of Disease At Wildlife-Livestock Interface In Africa -- 7 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Oceania -- 8 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In North America -- 9 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Central And South America -- Part 3 Characterization Of The Wildlife-Livestock Interface -- 10 Collecting Data To Assess The Interactions Between Livestock And Wildlife -- 11 Characterization Of Wildlife-Livestock Interfaces: The Need For Interdisciplinary Approaches And A Dedicated Thematic Field -- 12 Quantifying Transmission Between Wild And Domestic Populations -- Part 4 Synthesis And Conclusions -- 13 Synthesis And Future Perspectives Of The Study And Management Of Diseases At The Wildlife-Livestock Interface.

Description / Table of Contents: High pressure and High pressure environments -- High pressure: molecules, chemical processes and cellular structures -- The high pressure micro-environment of vertebrate load bearing joints- Effects of high pressure on the activity of ordinary animals, including humans, and on the function of their excitable cells and ion channels -- The effects of decompression and subsequent re-compression on the activity of deep sea animals and eukaryote cells. The isobaric collection of deep sea animals.-Molecular adaptation to high pressure: proteins in deep sea animals -- Molecular adaptation to high pressure: membranes -- Prokaryotes at high pressure in the Oceans and the Deep Biosphere -- Hydrothermal vents: the inhabitants, their way of life and their adaptation to high pressure -- Buoyancy at depth -- Divers: Air breathing animals, including humans, at high pressure -- Adaptation to high pressure in the laboratory -- High pressure equipment used in the laboratory, at sea and at depth.

Description / Table of Contents: Preface and Introduction -- Part I Risks and Impacts Enhancing the Vulnerability of Social-Ecological Systems -- Part II Environmental and Climate Change Impacts on Social-Ecological Systems – Conflict, Inequality and Human Security -- Part III Human Mobility and Social-Ecological Systems -- Part IV Enhancing the Sustainability and Resilience of Social-Ecological Systems – Some Recommended Paths -- Conclusions.

Description / Table of Contents: Introduction -- Part I. Ethology and Behavioral Ecology of Sea Otters -- Taxonomy and Evolution of Sea Otters -- Sea Otter Behavior: Morphologic, Physiologic, and Sensory Adaptations -- Sea Otter Foraging Behavior -- Social Structure of Marine Otters: Inter and Intraspecific Variation -- Reproductive Behavior of Male Sea Otters -- Reproductive Behavior of Female Sea Otters and Their Pups -- Sea Otter Behavior and Its Influence on Littoral Community Structure -- Sea Otter Predator Avoidance Behavior -- Sea Otters and the Maritime Fur Trade -- Part II. Ethology and Behavioral Ecology of Polar Bears -- Polar Bear Taxonomy and Evolution -- Polar Bear Behavior: Morphologic and Physiologic Adaptations -- Polar Bear Foraging Behavior -- Polar Bear Reproductive and Denning Behavior -- Polar Bear Maternal Care, Neonatal Development, and Social Behavior -- Polar Bear Behavior in Response to Climate Change -- Human-Polar Bear Interactions.

Description / Table of Contents: SECTION I. Natural and human environment of coastal ecosystems -- Chapter 1. Ecological modelling and conservation on the coasts of Mexico -- Chapter 2. SE Pacific: the ecosystem and its use along the Chilean and Peruvian coast -- SECTION II. Marine ecosystem models in the South East Pacific coast -- Chapter 3. Modelling the Northern Humboldt Current Ecosystem; from winds to predators -- Chapter 4. Marine ecosystem models in the South Pacific coast -- Chapter 5. Keystone Species Complexes and macroscopic properties for improving ecosystem-based conservation practices in kelp forest along the north-central Chilean coast -- Chapter 6. Exploring alternative management policies for benthic ecological systems of northern Chile (SE Pacific) -- SECTION III. Central Pacific, Caribbean and Atlantic coastal ecosystem models -- Chapter 7. How much biomass must remain at the sea after fishing to conserve ecosystem -- functioning? The case of the Monterey sardine in the Gulf of California, Mexico -- Chapter 8. Dynamic and spatial model of the coral reef of Banco Chinchorro Biosphere Reserve (Caribbean Sea) for assessment harvest scenarios: short-term responses -- Chapter 9. Ecological role of sharks assessed by Ecopath models -- SECTION IV. System-based conservation and management: conclusions -- Chapter 10. Graph theory in food webs: uses and applications for conservation of marine ecosystems -- Chapter 11. Modelling aim the conservation of coastal marine ecosystem in Latin America.

Description / Table of Contents: Chapter 1 - Ecosystem services as a tool for decision-making in Patagonia -- Chapter 2- Assessment of provisioning ecosystem services in terrestrial ecosystems of Santa Cruz province, Argentina -- Chapter 3 - Grazing management and provision of ecosystem services in Patagonian arid rangelands -- Chapter 4 - Synergies and trade-offs among ecosystem services and biodiversity in different forest types inside and off-reserve in Tierra del Fuego, Argentina -- Chapter 5 - Shrubland management in northwestern Patagonia: an evaluation of its short-term effects on multiple ecosystem services -- Chapter 6 - Silvopastoral systems in northern Argentine-Chilean Andean Patagonia: Ecosystem services provision in a complex territory -- Chapter 7 - Ecosystem services values of the northwestern Patagonian natural grasslands -- Chapter 8 - The ecosystem services provided by peatlands in Patagonia -- Chapter 9 - Restoration for provision of ecosystem services in Patagonia-Aysén, Chile -- Chapter 10 - The North American beaver invasion and the impact over the ecosystem services in the Tierra del Fuego archipelago -- Chapter 11 - Social links for a nexus approach from an ecosystem services perspective in Central-East Patagonia -- Chapter 12 - Salmon farming: is it possible to relate its impact to the waste remediation ecosystem service? -- Chapter 13 - Using the ecosystem services approach to understand the distributional effects of marine protected areas in the Chilean Patagonia -- Chapter 14 - Socio-cultural valuation of ecosystem services in Southern Patagonia, Argentina -- Chapter 15 - Looking beyond ecosystem services supply: co-production and access barriers in marine ecosystems of the Chilean Patagonia -- Chapter 16 - Ecosystem services and human well-being: a comparison of two Patagonian social-ecological systems -- Chapter 17 - Urban Planning In Arid Northern Patagonia Cities To Maximize Local Ecosystem Services Provision -- Chapter 18 - Land size, native forests and ecosystem services inequalities in the rural Chilean Patagonia -- Chapter 19 - Imaginaries, transformations and resistances in Patagonian territories from a socio-ecological perspective -- Chapter 20 - The challenges of implementing ecosystem services in the Argentinean and Chilean Patagonia -- Chapter 21 - Natural capital and local employment in Argentine Patagonia -- Chapter 22 - Ecosystem services in Patagonia: a synthesis and future directions. .

Description / Table of Contents: Part 1 Introduction and Biomedical Applications of Nanoparticles -- 1. Introduction to Nanomaterials and Nanotechnology -- 2. Biomedical Applications of Nanoparticles -- Part II-Polymeric Nanoparticles -- 3. Nanocrystallization and Nanoprecipitation Technologies -- 4. Microfluidics Technology for Nanoparticles and Equipment-. 5. Production of Nanocomposites via Extrusion Techniques -- 6. The Use of Supercritical Fluids Technologies for Nanoparticle Production -- 7. Salting out and Ionic Gelation Manufacturing Techniques for Nanoparticles -- 8. Nanogel Synthesis by Irradiation of Aqueous Polymer Solutions -- 9. Cellulose acetate based nanofibers: Synthesis, Manufacturing and Applications -- 10. Production of nanofibers, environmental challenges and solutions -- Part III-Lipid Nanoparticles -- 11. High Pressure Homogenization Techniques for Nanoparticles -- 12. Solvent emulsification evaporation and solvent emulsification diffusion techniques for nanoparticles -- 13. Ultrasound Activated Nanoemulsions -- 14. Multiple Emulsions: Emphasizing on industrial applications -- 15. Membrane techniques for the preparation of nanomaterials -- 16. Self-assembling Lipid Nanoparticles/Nanosystems (SLNN) using Hydrophilic Solvents: Overview and Industrial Uses -- 17. Nanoemulsions – An emerging technology in drug delivery -- Part IV- Metallic Nanoparticles -- 18. Manufacturing techniques for carbon nanotubes, gold nanoparticles and silver nanoparticles -- 19. Radio frequency (RF) plasma-based Synthesis of metallic Nano particles for Biomedical Application -- 20. Techniques for accurate sizing of nanoparticles -- 21. Silver nanoparticles synthesis from cyanobacteria: Environmental and biomedical applications -- 22. Selenium Nanoparticles: Green Synthesis and Exploitation -- Part V- Quality control for nanoparticles -- 23. Practical guidelines for the characterization and quality control of nanoparticlesin the pharmaceutical industry -- Part VI-Challenges in scale-up production of nanoparticles -- 24. Nanomedicine Scale-Up Technologies: Feasibilities and Challenges -- 25. Patent survey on recent technology for nanoparticles -- Part VII-Injectable Nanosystems -- 26. Injectable Nanosystems and Inherent Nano-Serum Interactions -- Part VIII- Future directions and challenges -- 27. Current Challenges and Future Directions in Nanomedicine.

Description / Table of Contents: Macro-, micro- and nanosensors based on biological / chemical materials -- Bactericidal, fungicidal and immunomodulating activity of nano-surfaces -- Enzymatic Tissue Biotests (MAO and AChE biotests) and Bioindicators -- Is it possible to detect less than one bacterial cell? -- SERS for bacterial, virus and protein bio-sensing -- Biosensors for virus detection -- Specific immobilization of rotaviruses for atomic force microscopy with using Langmuir antibody films based on amphiphilic polyelectrolytes -- Fluorimetric and SERS sensor systems for diagnostics and monitoring of catecholamines-dependent diseases -- Enhanced sensitivity rapid tests for the detection of sepsis marker procalcitonin -- Analytical capabilities of some biosensors for the determination of drugs -- Electrochemical DNA sensors based on nanostructured polymeric materials for determination of antitumor drugs -- Variants of amperometric biosensors in the determination of some micotoxins: analytical capabilities -- New class of diagnostic systems based on polyelectrolyte microcapsules for urea detection -- Bioluminescent nano- and micro-biosensing elements for detection of organophosphorous compounds -- Nano- and microelectrochemical biosensors for determining blood glucose -- Micro-Electrochemical SMBG Biosensor Chip Design Development for Sustainable Mass Production based on the Strategic Platform Patent Map -- Biological Fuel Cells: Applications in Health Service and Ecology -- Recent Trends in Fabrication and Applications of Wearable Bioelectronics for Early-Stage Disease Monitoring and Diagnosis -- Self-powered biosensors in medicine and ecology -- Self-powered implantable biosensors – a review of recent advancements and future perspectives.

Description / Table of Contents: Part 1. Basic Science -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- Botulinum Neurotoxins: Mechanism of Action -- Manufacturing and Clinical Formulations of Botulinum Neurotoxins -- Novel Native and Engineered Botulinum Neurotoxins -- Part 2. Clinical Practice -- Clinical Pharmacology of Botulinum Toxin Drugs -- The Use of Botulinum Toxin for Treatment of the Dystonias -- The Use of Botulinum Toxin for Treatment of Spasticity -- Use of Botulinum Toxin in Ophthalmology -- Hyperhidrosis and Aesthetics -- Use of Botulinum Toxin in Genitourinary System -- Gastrointestinal Uses of Botulinum Toxin -- The Use of Botulinum Toxin in the Management of Headache Disorders -- Botulinum Toxin and Pain -- The Use of Botulinum Toxin for Treatment of Depression.

Description / Table of Contents: The effect of curcumin supplementation on pulse wave velocity in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial -- Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer -- The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-blind, Randomized, Placebo-Controlled Trial -- Protective effects of curcumin phytosomes against high-fat diet-induced atherosclerosis -- Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-fed Rabbits -- Updated review on the role of curcumin in gastrointestinal cancers -- Curcumin can bind and interact with CRP: an in silico study -- Antifungal activities of curcumin and difluorinated curcumin against clinical dermatophyte isolates -- Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial -- Effect of Curcumin on Severity of Functional Dyspepsia; a Triple Blinded Clinical Trial -- Possible mechanisms and special clinical considerations of curcumin supplementation in patients with COVID-19 -- Paving the road toward exploiting the therapeutic effects of ginsenosides: an emphasis on autophagy and endoplasmic reticulum stress -- Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: A clinical review -- Plants with anti-addictive potential -- Use of Plant-Derived Natural Products in Sleep Disturbances -- The effects of nutraceuticals and herbal medicine on Candida albicans in oral candidiasis: a comprehensive review -- Pharmacological properties of the plant-derived natural products cannabinoids and implications for cardiovascular health -- Beneficial effects of plant-derived natural products on non-alcoholic fatty liver disease -- Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats -- Beneficial Medicinal Plants for Memory and Cognitive Functions Based on Traditional Persian Medicine -- The use of medicinal plants for the treatment of alopecia in the Canon of Avicenna: an evidence-based review -- Ethnobotanical uses, phytochemistry and pharmacology of different Rheum species (Polygonaceae): A review -- Genus Rosa: A review of ethnobotany, phytochemistry and traditional aspects according to Islamic traditional medicine (ITM) -- Ethnobotany, Phytochemistry, traditional and modern uses of Actaea racemosa L. (Black cohosh): A review -- Ethnobotany, phytochemistry and pharmacological features of Centella asiatica: a comprehensive review -- Ethnomedicinal uses, phytochemistry and pharmacology of different Cichorium species (Asteraceae): A review -- Medicinal species of the genus Berberis: A review of their traditional and ethnomedicinal uses, phytochemistry and pharmacology -- Protective effects of intravenous magnesium sulfate in stroke patients receiving amiodarone: A randomized controlled trial -- In silico identification of novel interactions for FABP5 (Fatty Acid-Binding Protein 5) with nutraceuticals: Possible repurposing approach.

Description / Table of Contents: Foreword -- Preface -- PART I: Evolution, genetics and distribution -- 1. Phylogenesis and evolution -- 2. Population genetics and genomics -- 3. Conservation and breeding -- 4 Biogeography and local adaptations -- 5. Mediterranean pines as invasive species -- PART II: Ecophysiology of Mediterranean pines: resistance to stress and perturbation -- 6. Physiological trade-offs under stress and perturbation -- 7. Carbon allocation dynamics under stress -- 8 -- Root systems under drought -- 9. Stress and tree mortality -- 10. Forest diseases affecting pines -- 11. Resistance to herbivorous insects -- PART III: Pine and mixed forest ecosystems under global climate change -- 12. Growth and vigor -- 13. Forest distribution resilience under climate change -- 14. Carbon and energy balance -- 15. Soil properties and biogeochemical functioning -- 16. Decomposition -- PART IV: Forest dynamics, biodiversity and biotic interactions -- 17. Dynamics of mixed pine-oak forests -- 18. Bird diversity -- 19 Soil micro- and macrofauna -- 20. Mycorhizae -- PART V: Forest fire ecology and management -- 21. Fire past present and future -- 22. Adaptations to fire -- 23. Post-fire soil erosion -- 24. The impact of grazing on understory fuel load -- 25. Post fire restoration -- 26. Predicting post-fire conifer regeneration in California -- 27. Remote sensing fire damage -- PART VI: Policy and Ecosystem services of Mediterranean pine and mixed forest ecosystems -- 28. Mediterranean forests and the United Nations sustainable development goals -- 29. Ecosystem services -- 30.Multi-disciplinary assessment of cultural ecosystem services supplied by Mediterranean pine and mixed forests -- PART VII: Afforestation and forest management policy -- 31. Dynamics and management of western Mediterranean pinewoods -- 32. From pine monoculture forests into sustainable mixed forest ecosystems -- 33. Forest policy in Israel -- 34. Water based forest management.

Description / Table of Contents: 1. Overview of the impact of protein interfacial instability on the development of biologic products -- 2. Protein adsorption at a gas-aqueous interface -- 3. Interfacial behaviors of proteins -- 4. Interfacial stresses during drug substance purification processes -- 5. Evaluation of interfacial stress during drug product development -- 6.Relating interfacial shear and dilatations stress-es to protein aggregation in mAbs -- 7. Analytical techniques for evaluating protein instability at interfaces -- 8. Analysis of aggregates and particles -- 9. Protein interfacial instability of mixing and lyophilization during drug product manufacturing process scale-up and tech transfer -- 10. Excipients: Characterization, purpose, and selection -- 11. Interfacial stress and proteins prepared in the solid state -- 12. Interfaces in protein drug delivery: device concern -- 13. Future perspectives. .

Description / Table of Contents: 1. Introduction: Randall W. Myster -- 2. Dynamics of Andean Treeline Ecotones: Between Cloud Forest and Páramo Geocritical Tropes. Fausto O. Sarmiento -- 3. ANÁLISIS REGIONAL EN ECOSISTEMAS DE MONTAÑA EN COLOMBIA:Una mirada desde la funcionalidad del paisaje y los servicios ecosistémicos. Paola Isaacs-Cubides, Julián Díaz and Tobias Leyva-Pinto -- 4. Ecohydrology of Tropical Andean Cloud Forests. Conrado Tobon Martin -- 5. Litterfall in Andean forests: Quantity, composition, and environmental drivers. Wolfgang Wilcke -- 6. Arbuscular Mycorrhizal Fungi and Ectomycorrhizas in the Andean Cloud Forest of South Ecuador. Ingeborg Haug, Sabrina Setaro, Juan Pablo Suárez -- 7. Nesting ecology of the Tucuman Amazon (Amazona tucumana) in the cloud forest of Northwestern Argentina. Luis Rivera and Natalia Politi -- 8. Adaptive strategies of frugivore bats to Andean cloud forests. Adriana Ruiz and Pascual J. Soriano -- 9. Diversification and dispersal of Neotropical fauna: Processes and patterns in Andean species diversity. Juan C. Garcia-Ramirez and Angela M. Mendoza-Henao -- 10. Mapping Hydrological Ecosystem Services and Impacts of Scenarios for Deforestation and Conservation of Lowland, Montane and Cloud-Affected Forests. Mark Mulligan -- 11. Randall W. Myster. Conclusions, synthesis and future directions.

Description / Table of Contents: Chapter 1. Introduction to Veterinary Vaccines -- Chapter 2. "What is Required to Develop a Viral Vector Vaccine: Key Components of Vaccine-Induced Immune Responses" -- Chapter 3. Viruses and the evolution of viral vectors -- Chapter 4. The role of adjuvants in the application of viral vector vaccines -- Chapter 5. Adenovirus Vectors -- Chapter 6. Poxvirus Vectors -- Chapter 7. The Construction and Evaluation of Herpesvirus Vectors -- Chapter 8. Paramyxoviruses as Vaccine Vectors -- Chapter 9. Rhabdoviruses as vaccine vectors for veterinary pathogens -- Chapter 10. Coronaviruses as Vaccine Vector for Veterinary Pathogens -- Chapter 11. Alphavirus-Based Vaccines -- Chapter 12. Manufacturing and Control of Viral Vectored Vaccines: Challenges -- Chapter 13. Regulatory strategies and factors affecting veterinary viral vector development -- Chapter 14. "Emerging Viral Vectored Technology Future potential of capripoxvirus and African swine fever virus as viral vectors". .

Description / Table of Contents: Protein kinase-mediated decision between life and death -- Aging, cellular senescence and protein kinases -- Oxidative stress-related endothelial cell death and protein kinases -- Signal transduction in immune cells and protein kinases -- Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity -- Metabolic stress and immunity -- Activation of tropomyosin-related kinase receptor B by N-acetyl-serotonin: implications for neuroprotection -- Protein kinase inhibitors in traumatic brain injury and repair -- Amyloid beta toxicity in Alzheimer’s Disease and neuronal death-associated protein kinases -- Glucolipotoxicity-related beta cell death and protein kinases -- Protein kinases and cell death in hematological disorders -- A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy -- Bile acid toxicity and protein kinases -- Nanoparticle toxicity: Protein kinases and cell death -- Two-component signal transduction systems in antibiotic resistance -- ERK1/2 MAP kinase, its regulation and role in cellular activities including apoptosis and cell survival. .

Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: Regional context and maritime governance -- Chapter 3: Alboran Sea area climate and weather -- Chapter 4: The Oceanographic and climatic context -- Chapter 5: A Geological history for the Alboran Sea region -- Chapter 6: Seafloor morphology and processes in the Alboran Sea -- Chapter 7: The biogeochemical context of marine planktonic ecosystems -- Chapter 8: Seaweeds and seagrasses: the marine forests from the Alboran Sea -- Chapter 9: Benthic fauna of littoral and deep-sea habitats of the Alboran Sea: A hotspot of biodiversity -- Chapter 10: Invertebrates: the realm of diversity -- Chapter 11: Biogeographical and Macroecological context of the Alboran Sea -- Chapter 12: Biophysical processes determining the connectivity of the Alboran Sea fish populations -- Chapter 13: Evolving from fry fisheries to early life research on pelagic fish resources -- Chapter 14: Description of artisanal fisheries in northern Alboran Sea -- Chapter 15: Description of artisanal fisheries in southern Alboran Sea -- Chapter 16: Small pelagic resources: A historic perspective and current state of the resources -- Chapter 17: North Atlantic Oscillation effect on the biology and fisheries of tunas species in the Alboran Sea -- Chapter 18: Demersal Resources -- Chapter 19: The Blackspot seabream fishery in the Strait of Gibraltar: lessons and future perspectives of shared marine resource -- Chapter 20: Aquaculture in the Alboran Sea -- Chapter 21: Marine megafauna and charismatic vertebrate species -- Chapter 22: Fisheries economics and management under the impact of Human and varying marine environmental conditions in the Alboran Sea -- Chapter 23: A historical approach to living resources on the Spanish coasts from Alboran Sea between the 16th and 20th centuries -- Chapter 24: Sustainable development and Blue growth in the Alboran Sea: enabling ocean health and ecosystem services through ocean science and equitable governance -- Chapter 25: Marine Protected Areas and Key Biodiversity Areas of the Alboran Sea and adjacent areas.

Description / Table of Contents: Ecosystem Collapse and Climate Change: An Introduction -- PART I. Polar and Boreal Ecosystems -- Ecosystem Collapse on a Sub-Antarctic Island -- Permafrost Thaw in Northern Peatlands: Rapid Changes in Ecosystem and Landscape Functions -- Post-fire Recruitment Failure as a Driver of Forest to Non-forest Ecosystem Shifts in Boreal Regions -- A Paleo-perspective on Ecosystem Collapse in Boreal North America -- PART II. Temperate and Semi-arid Ecosystems -- The 2016 Tasmanian Wilderness Fires: Fire Regime Shifts and Climate Change in a Gondwanan Biogeographic Refugium -- Climate-Induced Global Forest Shifts due to Heatwave-Drought -- Extreme Events Trigger Terrestrial and Marine Ecosystem Collapses in the Southwestern USA and Southwestern Australia -- PART III. Tropical and Temperate Coastal Ecosystems -- Processes and Factors Driving Change in Mangrove Forests: An Evaluation Based on the Mass Dieback Event in Australia’s Gulf of Carpentaria -- Recurrent Mass-Bleaching and the Potential for Ecosystem Collapse on Australia’s Great Barrier Reef -- Sliding Toward the Collapse of Mediterranean Coastal Marine Rocky Ecosystems -- Marine Heatwave Drives Collapse of Kelp Forests in Western Australia -- Impact of Marine Heatwaves on Seagrass Ecosystems.

Description / Table of Contents: Preface -- Liposome Formulations as Adjuvants for Vaccines -- Polymeric nanoparticle-based vaccine adjuvants and delivery vehicles -- Virus-like particle vaccines against respiratory viruses and protozoan parasites -- Protein and Peptide Nanocluster Vaccines.

Description / Table of Contents: Basic semiologic principles to define coherent color palettes for vegetation mapping -- Plant species distributions and ecological complexity: mapping sampling-effort bias explicitly -- Mapping of biogeographical territories: flora, vegetation and landscape criteria -- Dynamic-catenal vegetation mapping as a tool for ecologic restoration, conservation and policy -- Climate Change, Wetland Management and Alpaca Pastoralism in the Bolivian High Andes Mountains -- Essays on geobotanic mapping in the Andes of Bolivia, with particular reference to the conservation status of vegetation -- Using geobotanical tools to map and assess ecosystem services (MAES) in southern Portugal -- Spatial representation of plant diversity at geographical scale: the Italian experience -- Cognitive mapping of forest fragments -- California ultramafic vegetation: a phytosociological update -- Plant associations of the Petasition officinalis alliance in the east Carpathians (Călimani and Gurghiu Mountains) -- Arthrocaulon (Arthrocnemum) macrostachyum plant communites in the Iberian Peninsula, Balaeric and Canary Islands (Spain and Portugal) -- Geosynphytosociological typology of the French atlantic coastal rocky cliffs vegetations -- Symphytosociology: a tool for landscape monitoring: case study from the Swiss Alps -- Why does Mediterranean vegetation seem so diverse? -- Coastal dune vegetation zonation in Italy: squeezed between environmental drivers and threats -- Topographic and other constraints on evergreen broad-leaved forests in the southeastern USA -- Role of riparian zones in reducing pollution of surface and ground water, and increasing agricultural production nutrient acquisition and storage in river catchments -- Vegetation and flora of sacred natural sites in northwestern Morocco – landscape context and conservation value -- The Kaga Coast in Japan: Natural ecosystem and cultural landscape insuring biodiversity -- Species and habitat biodiversity measurement and conservation at different fine scales.

Description / Table of Contents: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.

Description / Table of Contents: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.

Description / Table of Contents: Preface -- The marine physical environment during the Polar Night -- Light in the Polar Night -- Marine micro- and macroalgae in the Polar Night -- Zooplankton in the Polar Night -- Benthic communities in the Polar Night -- Fish ecology in the Polar Night -- Biological clocks and rhythms in polar organisms -- Sensor carrying platforms -- Operative habitat mapping and monitoring in the Polar Night -- The Polar Night exhibition: Life and light at the dead of night -- Index.

Description / Table of Contents: Abelmoschus maschatus -- Abrus precatorius -- Abutilon indicum -- Acacia catechu -- Acacia nilotica (A. arabica) -- Achillea millefolium -- Achyranthes aspera -- Aconitum napellus -- Acorus calamus -- Adiantum venustum (Adiantun capillus-veneris) -- Aegle marmelos -- Agrimonia eupatorium.-Alhagi maurorum -- Alkanna tinctoria -- Allium cepa -- Allium sativum -- Aloe vera -- Alpinia galangal -- Alpinia officinarum -- Alstonia scholaris -- Althaea officinalis -- Ammi majus -- Anacardium occidentale -- Anacyclus pyrethrum -- Andrographis paniculata -- Anethum graveolens -- Anthemis nobilis -- Apium graveolens -- Argemone Mexicana -- Aristolochia bracteolata -- Aristolochia fontanesii (A. longa) -- Aristolochia indica -- Aristolochia rotunda -- Artemisia absinthium -- Artemisia vulgaris -- Asparagus adscendens -- Asparagus officinalis -- Asparagus racemosus -- Atropa belladonna -- Azadirachta indica -- Bacopa monnieri -- Bauhinia tomentosa -- Berberis Aristata -- Berberis vulgaris -- Bombyx mori -- Borago officinalis -- Boswellia serrata -- Brassica nigra -- Butea monosperma -- Caccinia macranthera var. glauca (C. glauca) -- Caesalpinia bonduc (Caesalpinia bonducella) -- Cannabis sativa -- Capparis spinosa -- Cardiospermum halicacabum -- Carthamus tinctorius -- Carum carvi -- Cassia fistula -- Catharanthus roseus -- Celastrus paniculatus -- Centaurea behen -- Centella asiatica -- Chamaecrista absus (Cassia absus) -- Chamaemelum nobile (Anthemis nobilis) -- Cheilocostus speciosus (Costus Speciosus) -- Cichorium intybus -- Cinnamomum camphora -- Cinnamomum cassia -- Cinnamomum verum (C. zeylanicum) -- Citrullus colocynthis -- Clitoria ternatea -- Colchicum autumnale -- Colchicum luteum -- Commiphora gileadensis (C. opobalsamum) -- Commiphora myrrha -- Commiphora wightii (C. mukul) -- Convolvulus scammonia -- Cotoneaster nummularius -- Crocus sativus -- Croton tiglium -- Cullen corylifolium (Psoralea corylifolia) -- Cuminum cyminum -- Curcuma aromatica -- Curcuma longa -- Curcuma zedoaria -- Cuscuta chinensis -- Cuscuta reflexa -- Cydonia oblonga -- Cymbopogon schoenanthus -- Cyperus rotundus -- Datura stramonium -- Delphinium denudatum -- Dolichousnea longissimi (Usnea longissima) -- Doronicum pardalianches -- Embelia ribes -- Euphorbia hirta -- Euphorbia resinifera -- Ferula assa-foetida -- Ficus carica -- Ficus racemosa -- Foeniculum vulgare -- Fumaria officinalis -- Gentiana lutea -- Glycyrrhiza glabra -- Gymnema sylvestre -- Helleborus niger -- Hemidesmus Indicus -- Hibiscus rosa-sinensis -- Holarrhena pubescens (Holarrhena antidysenterica) -- Hyoscyamus niger -- Hyssopus officinalis -- Illicium verum -- Iris germanica -- Juniperus communi -- Justicia adhatoda (Adhatoda vasica) -- Lactuca sativa -- Lavandula stoechas -- Lawsonia inermis -- Lepidium sativum -- Linum usitatissimum -- Lupinus albus -- Malva sylvestris -- Marrubium vulgare -- Matricaria chamomilla -- Melia azedarach -- Melilotus officinalis -- Melissa officinalis -- Mesua ferrea -- Momordica charantia -- Moringa oleifera -- Myristica fragrans -- Myrtus communis -- Nageia nagi -- Nepeta cataria -- Nigella sativa -- Ocimum basilicum -- Ocimum gratissimum -- Ocimum tenuiflorum (Ocimum sanctum -- Operculina turpethum -- Paeonia emodi -- Pandanus odorifer (Pandanus Odoratissimus) -- Papaver somniferum -- Persicaria bistorta -- Phyllanthus emblica (Emblica officinalis) -- Picrorhiza kurroa -- Pimpinella anisum -- Piper cubeba -- Piper nigrum -- Pistacia lentiscus -- Plantago major -- Plantago ovata -- Plumbago zeylanica -- Polygonum aviculare -- Portulaca oleracea -- Quercus infectoria -- Rauvolfia serpentina -- Rheum emodi -- Rheum officinale -- Ricinus communis -- Rubia cordifolia -- Rumex vesicarius -- Ruta graveolens -- Salix caprea -- Salvia officinalis -- Santalum album -- Saussurea lappa -- Semecarpus anacardium -- Senna alexandrina -- Senna occidentalis -- Senna tora -- Sida cordifolia -- Smilax china;- Solanum americanum (S. nigrum) -- Sterculia urens -- Strychnos nux-vomica -- Swertia chirata -- Symplocos racemosa -- Syzygium cumini (Eugenia jambolana) -- Tamarindus indica -- Taraxacum officinale -- Taxus baccata -- Tephrosia purpurea -- Terminalia bellirica -- Terminalia chebula -- Thymus vulgaris -- Tinospora cordifolia -- Trachyspermum ammi (Ptychotis coptica) -- Tribulus terrestris -- Trigonella foenum-graecum -- Tussilago farfara -- Valeriana jatamansi (Nardostachys jatamansi) -- Verbena officinalis -- Vernonia anthelmintica (Baccharoides anthelmintica) -- Vigna unguiculata (Dolichos biflorus) -- Viola odorata -- Viscum album -- Withania somnifera -- Wrightia tinctoria -- Zingiber officinale -- Zingiber zerumbet -- Ziziphus jujuba -- Abbreviations -- Glossary -- Ayurvedic Terms of Diseases -- List of Referenced Books -- Index.

Description / Table of Contents: Chapter 1. Revisiting the concept of human disease (Mariano Bizzarri, Mirko Minini, and Noemi Monti) -- Chapter 2. Dynamical aspects of pharmacokinetic/pharmacodynamics and quantitative systems pharmacology models (Ioannis Loisios-Konstantinidis, Panteleimon D. Mavroudis, Panos Macheras) -- Chapter 3. The efficiency of multi-target drugs: a network approach (Lucas N. Alberca, Alan Talevi) -- Chapter 4. Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases (Vinicius M. Alvesa, Stephen J. Capuzzia, Nancy Baker, Eugene N. Muratov, Alexander Trospsha, and Anthony J. Hickey) -- Chapter 5. Big Data, Personalized Medicine and Network Pharmacology: beyond the current paradigms (Alessandro Giuliani and Virginia Todde) -- Chapter 6. Epigenetic Control Using Small Molecules in Cancer (Tomohiro Kozako, Yukihiro Itoh, Shinichiro Honda, Takayoshi Suzuki) -- Chapter 7. Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread (Mark AJ Chaplain) -- Chapter 8. Precision Oncology vs Phenotypic approaches in the management of cancer: a case for the postmitotic state (Armando Aranda-Anzaldo and Myrna A.R. Dent) -- Chapter 9. Migrastatics - anti-metastatic drugs targeting cancer cell invasion (Aneta Gandalovičová , Daniel Rosel , Jan Brábek) -- Chapter 10. Critical steps in Epithelial-Mesenchymal transition as target for cancer treatment (Evgeny V. Denisov, Mohit Kumar Jolly, Vitaly P. Shubin, Alexey S. Tsukanov, Nadezhda V. Cherdyntseva) -- Chapter 11. Targeting the tumor-associated macrophages for ‘normalizing’ cancer (Julia Kzhyshkowska) -- Chapter 12. Tumor Reversion induced by embryo and oocyte extracts (Sara Proietti, Andrea Pensotti and Alessandra Cucina) -- Chapter 13. Trabectedin, a drug acting on both cancer cells and the tumor microenvironment (Paola Allavena, Manuela Liguori, Cristina Belgiovine) -- Chapter 14. Advances in Characterizing Recently-identified Molecular Actions of Melatonin: Clinical Implications (Russel J. Reiter, Ramaswamy Sharma, Sergio A. Rosales-Corral, Ana Coto-Montes, Jose Antonio Boga, Jerry Vriend) -- Chapter 15. Multitarget activities of Inositol and Inositol Hexakisphosphate (Ivana Vucenik) -- Chapter 16. Integration of Phytochemicals and Phytotherapy into Cancer Precision Medicine (Nadire Özenver and Thomas Efferth) -- Chapter 17. Synergistic Effects of Chinese Herbal Medicine and Biological Networks (Deep Jyoti Bhuyan, Saumya Perera1, Kirandeep Kaur, Muhammad A. Alsherbiny, Mitchell Low, Sai-Wang Seto, Chun-Guang Li, Xian Zhou) -- Chapter 18. Medicinal herbs: its therapeutic use in obstetrics and gynaecology (Irene Orbe, Daniel Paz, Leyre Pejenaute, Andrea Puente, Laura Diaz de Alda, Sandra Yague, Iñaki Lete) -- Chapter 19. Overcoming Antibiotic Resistance: New Perspectives (Matteo Bassetti, Elda Righi).

Description / Table of Contents: Chapter 1: Introduction: Ecological Subsidies as a Framework for Understanding Contaminant Fate, Exposure, and Effects at the Land-Water Interface -- Part I: Ecological Subsidies Drive Exposure -- Chapter 2: Ecological Factors Controlling Insect-Mediated Methylmercury Flux from Aquatic to Terrestrial Ecosystems: Lessons Learned from Mesocosm and Pond Experiments -- Chapter 3: Pathways of Contaminant Transport Across the Aquatic-Terrestrial Interface: Implications for Terrestrial Consumers, Ecosystems and Management -- Part II: Exposure Drives Ecological Subsidies -- Chapter 4: Agriculture and Mining Contamination Contribute to a Productivity Gradient Driving Cross-Ecosystem Associations between Stream Insects and Riparian Arachnids -- Chapter 5: Cross-Ecosystem Linkages and Trace Metals at the Land-Water Interface -- Chapter 6: Metamorphosis and the Impact of Contaminants on Ecological Subsidies -- Part III: Other Global Stressors -- Chapter 7: Variables Affecting Resource Subsidies from Streams and Rivers to Land and their Susceptibility to Global Change Stressors -- Chapter 8: Beyond “Donors and Recipients”: Impacts of Species Gains and Losses Reverberate among Ecosystems due to Changes in Resource Subsidies -- Part IV: Management Applications and Tools -- Chapter 9: Practical Considerations for the Incorporation of Insect-Mediated Contaminant Flux into Ecological Risk Assessments -- Chapter 10: When Nutrients Become Contaminants in Aquatic Systems: Identifying Responses to Guide Terrestrial-Derived Detrital Endpoint Development for Managers -- Chapter 11: Mesocosms to Evaluate Aquatic-Terrestrial Contaminant Linkages using Aquatic Insect Emergence: Utility for Aquatic Life Criteria Development -- Chapter 12: Studying Effects of Contaminants on Aquatic-Terrestrial Subsidies: Experimental Designs using Outdoor and Indoor Mesocosms and Microcosms -- Part V: Syntheses -- Chapter 13: Ecological Networks as a Framework for Understanding and Predicting Contaminant Movement across the Land-Water Interface -- Chapter: 14: Synthesis: A Framework for Predicting the Dark Side of Ecological Subsidies.

Description / Table of Contents: Preface Chapter 1: Overview of the Immune System and its Pharmacological Targets -- Chapter 2: Modulation of the Innate Immune System -- Chapter 3: Modulation of the Adaptive Immune System -- Chapter 4: Respiratory Disorders of the Immune System and their Pharmacological Treatment -- Chapter 5: Inflammation of the Skin and its therapeutic topics -- Chapter 6: Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments -- Chapter 7: Mechanisms of Autoimmunity and Pharmacologic Treatments -- Chapter 8: Transplantation: Immunologic Principles and Pharmacologic Agents -- Chapter 9: Immunopathogenesis, Immunization, and Treatment of Infectious Diseases -- Chapter 10: Cancer Immunotherapy.

Description / Table of Contents: Rabies Life Cycle, Transmission and Pathogenesis -- History of Rabies and Rabies Vaccines -- Rabies vaccines for wildlife -- Human Rabies Vaccines -- Rabies vaccines, prophylactic, Peru -- Rabies Prevention in Asia: Institutionalizing Implementation Capacities -- Passive Immunity in Rabies Prophylaxis -- Rabies Little Virus Against Powerful Innate Immunity -- Novel Rabies Vaccines -- Assessing the potency of inactivated veterinary vaccines and oral live vaccines against rabies -- WHO Perspective on Rabies.

Description / Table of Contents: Part 1: Introduction -- Post Mortem Forensic Toxicology -- Human Performance Toxicology -- Drug-Facilitated Sexual Assault -- Forensic Drug Testing -- Performance enhancing Drug Testing -- Drug Testing in Pain Management -- Pharmacokinetics and Pharmacodynamics -- Part II. Specimen Preparation -- Spectrophotometry -- Chromatography -- Derivatization -- Immunoassy -- Mass Spectrometry -- Quantitation -- Method Validation -- Measurement Uncertainty and Traceability -- Statistics in Forensic Toxicology -- Part III Analytes -- Alcohol -- Benzodiazapines -- Gammahydroxybutyric acid,- Miscellaneous Central Nervous System Depressants -- Opioids -- Cocanie -- Cannabis -- Amphetamines-Sympathomimetic Amines,- Hallucinogens and Psychedelics -- Antidepressants and Neuroleptics -- Miscellaneous Therapeutic Drugs -- Carbon Monoxide/Cyanide -- Inhalants -- Metals -- Part III Special Topics -- Stability of Drugs of Abuse in Biological Systems -- Postmortem Redistribution of Drugs -- Postmortem Clinical Testing -- Pharmacogenomics -- Hair Drug Testing -- Oral Fluid Testing -- Meconium Drug Testing -- Drugs in Embalmed Tissues.

Description / Table of Contents: Introduction -- History of CROs: Including CRO Snapshots and a CRO Genealogy Chart -- The Pharmaceutical Development Process & Testing Requirements -- The Medical Device Development Process & Testing Requirements -- Functions and Types of CROs -- Labs in China and India -- Selection of CROs -- Study Directors and PIs -- Nuts and Bolts of Study Performance SCG/CBS -- Electronic Reporting Requirements (SEND & eCTD) -- Study and Project Monitoring -- Contracting, Pricing, and Cost of Works Performed by CROs -- Consultants and their Role -- Building Relationships: Maximizing your return on Expectations with a CRO -- Common Problems and their Solutions -- Appendices: A Toxicology Labs B Medical Device Labs C Phase I Labs D Analytical Labs E GMP Contract Facilities F Formulation G Dosage Forms H Clinical Testing I Regulatory Services J Forms and Checklists -- K Specialized Services -- L Consultants Known to be In-Practice -- Index. .

Description / Table of Contents: 1. Introduction: aquatic insects in Australia’s environments -- 1.1. The background to concern -- References -- 2. Major habitats -- 2.1. Introduction -- 2.2. Ponds and lakes -- 2.3. Streams and rivers -- References -- 3. Australian inland waters -- 3.1. Introduction -- 3.2. Waterfalls -- 3.3. Subterranean aquifers -- 3.4. Rock pools -- 3.5. Mound springs -- 3.6. Lakes -- 3.7. Billabongs -- 3.8. Streams and rivers -- 3.9. Exposed riverine sediments -- References -- 4. Monitoring freshwater macroinvertebrates -- 4.1. Scope and needs for assessments -- References -- 5. Threats: the background variations in condition -- 5.1. Introduction -- 5.2. Drought -- 5.3. Flood -- References -- 6. Major imposed threats -- 6.1. Introduction -- 6.2. Water temperature -- 6.3. Sedimentation -- 6.3.1. Mining -- 6.4. Pollution -- 6.5. Salinisation -- 6.6. Exploitation -- 6.7. Electrofishing -- 6.8. Changes to riparian vegetation -- 6.8.1. Emergent vegetation -- 6.9. Alien species -- 6.9.1. Plants -- 6.9.2. Fish -- 6.9.3. Mammals -- 6.10. River regulation -- 6.11. Fire -- 6.12. Urbanisation -- 6.13. Recreation -- 6.14. Ecological traps -- 6.15. Climate change -- References -- 7. Macroinvertebrates of inland waters -- 7.1. Introduction -- 7.2. The variety of aquatic insects -- 7.3. Other macroinvertebrates -- 7.3.1. Crustaceans -- 7.3.2. Molluscs -- References -- 8. Insects of Australia’s inland waters -- 8.1. Introduction -- 8.2. Ephemeroptera -- 8.3. Odonata -- 8.4. Plecoptera -- 8.5. Hemiptera -- 8.6. Coleoptera -- 8.7. Mecoptera -- 8.8. Megaloptera -- 8.9. Neuroptera -- 8.10. Lepidoptera -- 8.11. Trichoptera -- 8.12. Diptera -- 8.12.1. Control of aquatic pest flies -- References -- 9. Australia’s flagship freshwater insects -- 9.1. Introduction -- 9.2. Selected flagship taxa -- References -- 10. Ecology and management -- 10.1. Introduction -- 10.2. Dispersal -- 10.2.1. Impacts of urban lighting -- 10.2.2. Pond colonization -- References -- 11. Conservation -- 11.1. Introduction -- 11.2. Protected areas -- 11.3. Management and restoration -- 11.4. Fish conservation -- 11.5. Education and involvement -- 11.6. Artificial water bodies -- 11.7. Temporary ponds -- 11.8. Intermittent streams -- 11.9. Stormwater retention ponds -- 11.10. Refuges -- 11.11. Woody debris -- 11.12. Riparian zones -- 11.13. Perspective and prospects -- References -- Appendix 1 -- Index.

Description / Table of Contents: 1. History of development of botulinum toxin therapy in medical and surgical fields -- 2. Molecular structure and mechanisms of action of botulinum toxins as it pertains to clinical symptoms -- 3. Types of toxins in commercial use, their similarities and differences -- 4. A review of current Botulinum toxin treatment indications in medical field. - 5. Mechanisms of Analgesic effects of botulinum neurotoxins -- 6. Botulinum toxin treatment in Head and neck surgery -- 7. Botulinum toxin treatment of thoracic and abdominal surgery -- 8. Botulinum Toxin A in Abdominal Wall Reconstruction -- 9. Use of Botulinum toxin A in post-mastectomy breast reconstruction -- 10. Botulinum Toxins for Treatment of Pain in Orthopedic Disorders -- 11. Botulinum toxin for pediatric patients, Who? For what? When? -- 12. Botulinum Toxin Treatment in Plastic Surgery -- 13. Botulinum Toxin Treatment in Ophthalmology and Ophthalmic surgery -- 14. Botulinum Toxin Treatment in Gastrointestinal Disorders -- 15. Botulinum Toxin Treatment in Urological Disorders -- 16. Botulinum Toxin Treatment in Dentistry -- 17. Botulinum toxin treatment in Veterinary Medicine - Clinical implications -- 18. Future Perspectives of Botulinum Toxin Application In Dentistry.

Description / Table of Contents: Nano-technological Platforms and Manipulations for the Emerging Ocular Manifestations -- Phytonanomedicines as Topical Alternatives for the Treatment of Skin Cancer -- Nano-sized Labile and Particulate Ingredients in Topical Formulations: A Strategic Approach Against Photoageing and Photocarcinogenisis -- Application of Biocompatible Nanocarriers in Glaucoma: Challenges and Advances -- Nano-carriers for Natural Therapeutics in the Management of Neuropathic Pain -- Advances in the Delivery of Therapeutic Peptides -- Nanoformulations and Their Role in Colon Targeting -- Theranostic Nanoformulations: Merging Diagnostics and Therapeutics -- The Role of Nanoformulations in Nose-To-Brain Drug Delivery -- Cubic Lyotropic Liquid Crystalline Nanostructures: A Versatile Platform for Delivery -- Preformulation Challenges: The Concept Behind the Selection, Design, and Preparation of Nanoformulations -- Nanoethosomes for Topical Fungal Therapeutics -- Comparison of Therapeutic Efficiency of Nanoformulations of Curcumin vs. Tetrahydrocurcumin in Various Disorders -- Nanomedicinal Approaches of Phytotherapeutics to Treat Alzheimers Disease -- Nanoparticulate Approaches to Exploit the Pathophysiology of Rheumatoid and Osteoarthritis -- Emerging Nanotechnology in Chronic Respiratory Diseases -- Conventional and Non-conventional Approaches of Site-specific Targeting of Therapeutics in Some Infectious Diseases and Metabolic Disorders -- Nanoformulations in Human Health Conditions: The Paradigm Shift -- Magnetic Nanoparticles Nanoformulation for Alternative Therapy of Cancer by Super-paramagnetic Hyperthermia -- Nano-weapons Against Tuberculosis -- Drug-Excipient Interactions in Nanoformulations with Special Focus on Impurity Control per ICH guidelines.

Description / Table of Contents: Part 1-Nanotechnology in Skin Infections -- Atopic dermatitis and current trends in pharmacological treatment - a nanoparticulate approach -- Acne vulgaris - recent trends on pharmacological and nanotechnological approaches in therapeutics -- Nitric oxide nanoparticles on skin infections: Current State and Future Prospects -- Metal Nanoparticles Based Antibacterial Nanocomposites for Skin Infections -- Combination therapy using metal nanoparticles for skin infection -- Applications of nanometals in cutaneous infections -- Antifungal nanotherapy: a novel approach to combat superficial fungal infections -- Biocompatible polymers for skin Nanomedicines -- Part 2-Nanotechnology on Soft-Tissue Infections -- Nanotechnological approach to manage diabetic foot ulcer -- Metal nanoparticles in wound infections -- Advances in nanomedicine for burn wound infection treatment -- Applications of chitosan in formulation of novel antibacterial agents and wound dressings -- Polymeric nanocomposites for skin and soft tissues -- Nanoformulations of polyphenols for the treatment of soft tissues infections -- Cutting Edge Nanotechnologies for Targeting Liver Disorders -- NanoCurcumin compounds formulations: Perspectives in skin and soft tissues infections -- Nanobiotechnology strategies for the treatment tegumentary and visceral leishmaniases, and emergence resistance -- Part 3-Nanotechnology in Bone Infections -- Artificial Scaffolds for Bone Tissue Engineering -- The bone biology and the nanotechnology for bone infections and bone engineering -- Part 4-Nanotechnology and Toxicity -- Genotoxicity studies of Silver Nanoparticles in in vivo and in vitro models.