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  • 1
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    Future Internet, Vol. 6, Pages 688-716: The ARCOMEM Architecture for Social- and Semantic-Driven Web Archiving (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-11-05
    Description: The constantly growing amount ofWeb content and the success of the SocialWeb lead to increasing needs for Web archiving. These needs go beyond the pure preservationo of Web pages. Web archives are turning into “community memories” that aim at building a better understanding of the public view on, e.g., celebrities, court decisions and other events. Due to the size of the Web, the traditional “collect-all” strategy is in many cases not the best method to build Web archives. In this paper, we present the ARCOMEM (From Future Internet 2014, 6 689 Collect-All Archives to Community Memories) architecture and implementation that uses semantic information, such as entities, topics and events, complemented with information from the Social Web to guide a novel Web crawler. The resulting archives are automatically enriched with semantic meta-information to ease the access and allow retrieval based on conditions that involve high-level concepts..
    Electronic ISSN: 1999-5903
    Topics: Computer Science
    Published by MDPI Publishing
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  • 2
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    Algorithms, Vol. 7, Pages 685-702: Fusion of Multiple Pyroelectric Characteristics for Human Body Identification (2014)
    MDPI Publishing
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    Publication Date: 2014-12-19
    Description: Due to instability and poor identification ability of single pyroelectric infrared (PIR) detector for human target identification, this paper proposes a new approach to fuse the information collected from multiple PIR sensors for human identification. Firstly, Fast Fourier Transform (FFT), Short Time Fourier Transform (STFT), Wavelet Transform (WT) and Wavelet Packet Transform (WPT) are adopted to extract features of the human body, which can be achieved by single PIR sensor. Then, we apply Principal Component Analysis (PCA) and Support Vector Machine (SVM) to reduce the characteristic dimensions and to classify the human targets, respectively. Finally, Fuzzy Comprehensive Evaluation (FCE) is utilized to fuse recognition results from multiple PIR sensors to finalize human identification. The pyroelectric characteristics under scenarios with different people and/or different paths are analyzed by various experiments, and the recognition results with/without fusion procedure are also shown and compared. The experimental results demonstrate our scheme has improved efficiency for human identification.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
    Published by MDPI Publishing
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  • 3
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    Future Internet, Vol. 6, Pages 1-60: A Comparison of Internet Protocol (IPv6) Security Guidelines (2014)
    MDPI Publishing
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    Publication Date: 2014-01-11
    Description: The next generation of the Internet Protocol (IPv6) is currently about to be introduced in many organizations. However, its security features are still a very novel area of expertise for many practitioners. This study evaluates guidelines for secure deployment of IPv6, published by the U.S. NIST and the German federal agency BSI, for topicality, completeness and depth. The later two are scores defined in this paper and are based on the Requests for Comments relevant for IPv6 that were categorized, weighted and ranked for importance using an expert survey. Both guides turn out to be of practical value, but have a specific focus and are directed towards different audiences. Moreover, recommendations for possible improvements are presented. Our results could also support strategic management decisions on security priorities as well as for the choice of security guidelines for IPv6 roll-outs.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
    Published by MDPI Publishing
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  • 4
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    Algorithms, Vol. 7, Pages 1-14: On Stable Matchings and Flows (2014)
    MDPI Publishing
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    Publication Date: 2014-01-23
    Description: We describe a flow model related to ordinary network flows the same way as stable matchings are related to maximum matchings in bipartite graphs. We prove that there always exists a stable flow and generalize the lattice structure of stable marriages to stable flows. Our main tool is a straightforward reduction of the stable flow problem to stable allocations. For the sake of completeness, we prove the results we need on stable allocations as an application of Tarski’s fixed point theorem.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 5
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    Algorithms, Vol. 7, Pages 206-228: Stochastic Diffusion Search: A Comparison of Swarm Intelligence Parameter Estimation Algorithms with RANSAC (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-05-06
    Description: Stochastic diffusion search (SDS) is a multi-agent global optimisation technique based on the behaviour of ants, rooted in the partial evaluation of an objective function and direct communication between agents. Standard SDS, the fundamental algorithm at work in all SDS processes, is presented here. Parameter estimation is the task of suitably fitting a model to given data; some form of parameter estimation is a key element of many computer vision processes. Here, the task of hyperplane estimation in many dimensions is investigated. Following RANSAC (random sample consensus), a widely used optimisation technique and a standard technique for many parameter estimation problems, increasingly sophisticated data-driven forms of SDS are developed. The performance of these SDS algorithms and RANSAC is analysed and compared for a hyperplane estimation task. SDS is shown to perform similarly to RANSAC, with potential for tuning to particular search problems for improved results.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
    Published by MDPI Publishing
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  • 6
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    Algorithms, Vol. 7, Pages 15-31: Bio-Inspired Meta-Heuristics for Emergency Transportation Problems (2014)
    MDPI Publishing
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    Publication Date: 2014-02-12
    Description: Emergency transportation plays a vital role in the success of disaster rescue and relief operations, but its planning and scheduling often involve complex objectives and search spaces. In this paper, we conduct a survey of recent advances in bio-inspired meta-heuristics, including genetic algorithms (GA), particle swarm optimization (PSO), ant colony optimization (ACO), etc., for solving emergency transportation problems. We then propose a new hybrid biogeography-based optimization (BBO) algorithm, which outperforms some state-of-the-art heuristics on a typical transportation planning problem.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 7
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    Algorithms, Vol. 7, Pages 32-59: Choice Function-Based Two-Sided Markets: Stability, Lattice Property, Path Independence and Algorithms (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-02-15
    Description: We build an abstract model, closely related to the stable marriage problem and motivated by Hungarian college admissions. We study different stability notions and show that an extension of the lattice property of stable marriages holds in these more general settings, even if the choice function on one side is not path independent. We lean on Tarski’s fixed point theorem and the substitutability property of choice functions. The main virtue of the work is that it exhibits practical, interesting examples, where non-path independent choice functions play a role, and proves various stability-related results.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 8
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    Future Internet, Vol. 6, Pages 171-189: Mobility Tolerant Firework Routing for Improving Reachability in MANETs (2014)
    MDPI Publishing
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    Publication Date: 2014-03-25
    Description: In this paper, we investigate our mobility-assisted and adaptive broadcast routing mechanism, called Mobility Tolerant Firework Routing (MTFR), which utilizes the concept of potentials for routing and improves node reachability, especially in situations with high mobility, by including a broadcast mechanism. We perform detailed evaluations by simulations in a mobile environment and demonstrate the advantages of MTFR over conventional potential-based routing. In particular, we show that MTFR produces better reachability in many aspects at the expense of a small additional transmission delay and intermediate traffic overhead, making MTFR a promising routing protocol and feasible for future mobile Internet infrastructures.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
    Published by MDPI Publishing
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  • 9
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    Future Internet, Vol. 6, Pages 190-202: The Problems and Challenges of Managing Crowd Sourced Audio-Visual Evidence (2014)
    MDPI Publishing
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    Publication Date: 2014-04-02
    Description: A number of recent incidents, such as the Stanley Cup Riots, the uprisings in the Middle East and the London riots have demonstrated the value of crowd sourced audio-visual evidence wherein citizens submit audio-visual footage captured on mobile phones and other devices to aid governmental institutions, responder agencies and law enforcement authorities to confirm the authenticity of incidents and, in the case of criminal activity, to identify perpetrators. The use of such evidence can present a significant logistical challenge to investigators, particularly because of the potential size of data gathered through such mechanisms and the added problems of time-lining disparate sources of evidence and, subsequently, investigating the incident(s). In this paper we explore this problem and, in particular, outline the pressure points for an investigator. We identify and explore a number of particular problems related to the secure receipt of the evidence, imaging, tagging and then time-lining the evidence, and the problem of identifying duplicate and near duplicate items of audio-visual evidence.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
    Published by MDPI Publishing
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  • 10
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    Algorithms, Vol. 7, Pages 188: Correction: Pareto Optimization or Cascaded Weighted Sum: A Comparison of Concepts. Algorithms 2014, 7, 166–185 (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-04-03
    Description: It has come to our attention that due to an error in producing the PDF version of the paper [1], doi:10.3390/a7010166, website: http://www.mdpi.com/1999-4893/7/1/166, Figures 1 and 9 are displayed incorrectly.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 11
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    Algorithms, Vol. 7, Pages 189-202: Faster and Simpler Approximation of Stable Matchings (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-04-05
    Description: We give a 3 2 -approximation algorithm for finding stable matchings that runs in O(m) time. The previous most well-known algorithm, by McDermid, has the same approximation ratio but runs in O(n3/2m) time, where n denotes the number of people andm is the total length of the preference lists in a given instance. In addition, the algorithm and the analysis are much simpler. We also give the extension of the algorithm for computing stable many-to-many matchings.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 12
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    Algorithms, Vol. 7, Pages 597-607: Eight-Scale Image Contrast Enhancement Based on Adaptive Inverse Hyperbolic Tangent Algorithm (2014)
    MDPI Publishing
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    Publication Date: 2014-10-29
    Description: The Eight-Scale parameter adjustment is a natural extension of Adaptive Inverse Hyperbolic Tangent (AIHT) algorithm. It has long been known that the Human Vision System (HVS) heavily depends on detail and edge in the understanding and perception of scenes. The main goal of this study is to produce a contrast enhancement technique to recover an image from blurring and darkness, and at the same time to improve visual quality. Eight-scale coefficient adjustments can provide a further local refinement in detail under the AIHT algorithm. The proposed Eight-Scale Adaptive Inverse Hyperbolic Tangent (8SAIHT) method uses the sub-band to calculate the local mean and local variance before the AIHT algorithm is applied. This study also shows that this approach is convenient and effective in the enhancement processes for various types of images. The 8SAIHT is also capable of adaptively enhancing the local contrast of the original image while simultaneously extruding more on object details.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 13
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    Future Internet, Vol. 6, Pages 612-639: From Raw Data to Meaningful Information: A Representational Approach to Cadastral Databases in Relation to Urban Planning (2014)
    MDPI Publishing
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    Publication Date: 2014-10-25
    Description: Digesting the data hose that cities are constantly producing is complex; data is usually structured with different criteria, which makes comparative analysis of multiple cities challenging. However, the publicly available data from the Spanish cadaster contains urban information in a documented format with common semantics for the whole territory, which makes these analyses possible. This paper uses the information about the 3D geometry of buildings, their use and their year of construction, stored in cadastral databases, to study the relation between the built environment (what the city is) and the urban plan (what the city wants to become), translating the concepts of the cadastral data into the semantics of the urban plan. Different representation techniques to better understand the city from the pedestrians’ point of view and to communicate this information more effectively are also discussed.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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  • 14
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    Future Internet, Vol. 6, Pages 640-672: Towards a Conceptual Framework for WikiGIS (2014)
    MDPI Publishing
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    Publication Date: 2014-10-30
    Description: As an emerging complex concept, GeoDesign requires an innovative theoretical basis, tools, supports and practices. For this reason, we propose a new concept, “WikiGIS”, designed to answer some dimensions of the GeoDesign process. WikiGIS focuses on the needs of GeoDesign, but we leave the door open for future improvement when tested in other areas that may have additional needs. WikiGIS is built on Web 2.0 technologies—and primarily on wiki—to manage the tracking of participants’ editing (i.e., managing the contributions history). It also offers GIS functions for geoprocessing and a design-based approach for sketching proposals. One of the main strengths of WikiGIS is its ability to manage the traceability of contributions with an easy and dynamical access, data quality and deltification. The core of this paper consists of presenting a conceptual framework for WikiGIS using UML diagrams. A user interface is presented later to show how our WikiGIS proposal works. This interface is simply a means to illustrate the concepts underlying WikiGIS.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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  • 15
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    Algorithms, Vol. 7, Pages 608-620: High-Order Entropy Compressed Bit Vectors with Rank/Select (2014)
    MDPI Publishing
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    Publication Date: 2014-11-04
    Description: We design practical implementations of data structures for compressing bit-vectors to support efficient rank-queries (counting the number of ones up to a given point). Unlike previous approaches, which either store the bit vectors plainly, or focus on compressing bit-vectors with low densities of ones or zeros, we aim at low entropies of higher order, for example 101010...10. Our implementations achieve very good compression ratios, while showing only a modest increase in query time.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 16
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    Algorithms, Vol. 7, Pages 582-596: Processing KNN Queries in Grid-Based Sensor Networks (2014)
    MDPI Publishing
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    Publication Date: 2014-10-24
    Description: Recently, developing efficient processing techniques in spatio-temporal databases has been a much discussed topic. Many applications, such as mobile information systems, traffic control system, and geographical information systems, can benefit from efficient processing of spatio-temporal queries. In this paper, we focus on processing an important type of spatio-temporal queries, the K-nearest neighbor (KNN) queries. Different from the previous research, the locations of objects are located by the sensors which are deployed in a grid-based manner. As the positioning technique used is not the GPS technique, but the sensor network technique, this results in a greater uncertainty regarding object location. With the uncertain location information of objects, we try to develop an efficient algorithm to process the KNN queries. Moreover, we design a probability model to quantify the possibility of each object being the query result. Finally, extensive experiments are conducted to demonstrate the efficiency of the proposed algorithms.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 17
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    Algorithms, Vol. 7, Pages 554-581: Parallelizing Particle Swarm Optimization in a Functional Programming Environment (2014)
    MDPI Publishing
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    Publication Date: 2014-10-24
    Description: Many bioinspired methods are based on using several simple entities which search for a reasonable solution (somehow) independently. This is the case of Particle Swarm Optimization (PSO), where many simple particles search for the optimum solution by using both their local information and the information of the best solution found so far by any of the other particles. Particles are partially independent, and we can take advantage of this fact to parallelize PSO programs. Unfortunately, providing good parallel implementations for each specific PSO program can be tricky and time-consuming for the programmer. In this paper we introduce several parallel functional skeletons which, given a sequential PSO implementation, automatically provide the corresponding parallel implementations of it. We use these skeletons and report some experimental results. We observe that, despite the low effort required by programmers to use these skeletons, empirical results show that skeletons reach reasonable speedups.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 18
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    Future Internet, Vol. 6, Pages 673-687: The Gender Digital Divide in Developing Countries (2014)
    MDPI Publishing
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    Publication Date: 2014-11-01
    Description: Empirical studies clearly show that women in the developing world have significantly lower technology participation rates than men; a result of entrenched socio-cultural attitudes about the role of women in society. However, as studies are beginning to show, when those women are able to engage with Internet technology, a wide range of personal, family and community benefits become possible. The key to these benefits is on-line education, the access to which sets up a positive feedback loop. This review gives an overview of the digital divide, before focusing specifically on the challenges women in developing countries face in accessing the Internet. Current gender disparities in Internet use will be outlined and the barriers that potentially hinder women’s access and participation in the online world will be considered. We will then look at the potential opportunities for women’s participation in a global digital society along with a consideration of current initiatives that have been developed to mitigate gender inequity in developing countries. We will also consider a promising avenue for future research.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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  • 19
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    Future Internet, Vol. 6, Pages 542-555: Neogeography and Preparedness for Real-to-Virtual World Knowledge Transfer: Conceptual Steps to Minecraft Malta (2014)
    MDPI Publishing
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    Publication Date: 2014-08-29
    Description: Societies have rapidly morphed into complex entities that are creating accessibility, yet, at the same time, they are developing new forms of neogeographic-poverty related to information uptake. Those that have managed to partake in the opportunities provided by the web have new vistas to survive in, in contrast to the new poor who have limited or no access to information. New forms of data in spatial format are accessible to all, however few realize the implications of such a transitional change in wellbeing: Whether entire societies or individuals. The different generations taking up the information access can face different levels of accessibility that may be limited by access to online data, knowledge of usage of tools and the understanding of the results, all within the limits on the spaces they are familiar with. This paper reviews a conceptual process underlining the initial steps of a long-term project in the Maltese Islands that seeks to create an online series of tools that bring the concept of “physical place” to the different generations through the management of a major project, the creation of a 3D virtuality, employing scanning processes, GIS, conversion aspects, and a small block-based Minecraft engine.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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  • 20
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    Future Internet, Vol. 6, Pages 597-611: Geography Geo-Wiki in the Classroom: Using Crowdsourcing to Enhance Geographical Teaching (2014)
    MDPI Publishing
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    Publication Date: 2014-09-30
    Description: Geo-Wiki is a crowdsourcing tool used to derive information, based on satellite imagery, to validate and enhance global land cover. Around 5000 users are registered, who contribute to different campaigns to collect data across various domains (e.g., agriculture, biomass, human impact, etc.). However, seeing the Earth’s surface from above does not provide all of the necessary information for understanding what is happening on the ground. Instead, we need to enhance this experience with local knowledge or with additional information, such as geo-located photographs of surface features with annotation. The latest development in enhancing Geo-Wiki in this context has been achieved through collaboration with the University of Waterloo to set up a separate branch called Geography Geo-Wiki for use in undergraduate teaching. We provide the pedagogical objectives for this branch and describe two modules that we have introduced in first and third year Physical Geography classes. The majority of the feedback was positive and in, many cases, was part of what the student liked best about the course. Future plans include the development of additional assignments for the study of environmental processes using Geo-Wiki that would engage students in a manner that is very different from that of conventional teaching.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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  • 21
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    Algorithms, Vol. 7, Pages 492-509: Power Cable Fault Recognition Based on an Annealed Chaotic Competitive Learning Network (2014)
    MDPI Publishing
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    Publication Date: 2014-09-27
    Description: In electric power systems, power cable operation under normal conditions is very important. Various cable faults will happen in practical applications. Recognizing the cable faults correctly and in a timely manner is crucial. In this paper we propose a method that an annealed chaotic competitive learning network recognizes power cable types. The result shows a good performance using the support vector machine (SVM) and improved Particle Swarm Optimization (IPSO)-SVM method. The experimental result shows that the fault recognition accuracy reached was 96.2%, using 54 data samples. The network training time is about 0.032 second. The method can achieve cable fault classification effectively.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 22
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    Algorithms, Vol. 7, Pages 650-662: Time Series Prediction Method of Bank Cash Flow and Simulation Comparison (2014)
    MDPI Publishing
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    Publication Date: 2014-11-27
    Description: In order to improve the accuracy of all kinds of information in the cash business and enhance the linkage between cash inventory forecasting and cash management information in the commercial bank, the first moving average prediction method, the second moving average prediction method, the first exponential smoothing prediction and the second exponential smoothing prediction methods are adopted to realize the time series prediction of bank cash flow, respectively. The prediction accuracy of the cash flow time series is improved by optimizing the algorithm parameters. The simulation experiments are carried out on the reality commercial bank’s cash flow data and the predictive performance comparison results show the effectiveness of the proposed methods.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 23
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    Algorithms, Vol. 7, Pages 635-649: The Lobe Fissure Tracking by the Modified Ant Colony Optimization Framework in CT Images (2014)
    MDPI Publishing
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    Publication Date: 2014-11-25
    Description: Chest computed tomography (CT) is the most commonly used technique for the inspection of lung lesions. However, the lobe fissures in lung CT is still difficult to observe owing to its imaging structure. Therefore, in this paper, we aimed to develop an efficient tracking framework to extract the lobe fissures by the proposed modified ant colony optimization (ACO) algorithm. We used the method of increasing the consistency of pheromone on lobe fissure to improve the accuracy of path tracking. In order to validate the proposed system, we had tested our method in a database from 15 lung patients. In the experiment, the quantitative assessment shows that the proposed ACO method achieved the average F-measures of 80.9% and 82.84% in left and right lungs, respectively. The experiments indicate our method results more satisfied performance, and can help investigators detect lung lesion for further examination.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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  • 24
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    Future Internet, Vol. 6, Pages 735-759: Public Involvement in Taking Legislative Action as to the Spatial Development of the Tourist Sector in Greece—The “OpenGov” Platform Experience (2014)
    MDPI Publishing
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    Publication Date: 2014-11-26
    Description: By the Aarhus Convention (1998) it is recognized the right of citizens to get access to and influence decision-making in respect to issues affecting the state of the environment. More specifically, in Article 8 it is stated that public authorities are forced to engage public participation when preparing regulations or legally binding rules that have a significant environmental impact. Towards this end, Information and Communication Technologies (ICTs) and their applications have considerably expanded the potential of planners and decision makers to interact with stakeholders and the public and engage them in participatory processes through ICTs-enabled platforms. The focus of the present paper is on the context of public consultation in taking legislative action as to the spatial development of the tourist sector in Greece. It consists of three parts: the first part, where the context of engaging the public in governmental decision-making in Greece is discussed, following the Open Government Partnership (OGP) initiative; the second part, presenting the steps of the “OpenGov” online platform, designed for gathering public knowledge to further improve legislative efforts and policy; and the third part, elaborating on the experience gained by the use of the “OpenGov” platform for decision-making on the spatial development of the tourist sector in Greece.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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    Future Internet, Vol. 6, Pages 760-772: Reducing Risky Security Behaviours: Utilising Affective Feedback to Educate Users (2014)
    MDPI Publishing
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    Publication Date: 2014-11-28
    Description: Despite the number of tools created to help end-users reduce risky security behaviours, users are still falling victim to online attacks. This paper proposes a browser extension utilising affective feedback to provide warnings on detection of risky behaviour. The paper provides an overview of behaviour considered to be risky, explaining potential threats users may face online. Existing tools developed to reduce risky security behaviours in end-users have been compared, discussing the success rates of various methodologies. Ongoing research is described which attempts to educate users regarding the risks and consequences of poor security behaviour by providing the appropriate feedback on the automatic recognition of risky behaviour. The paper concludes that a solution utilising a browser extension is a suitable method of monitoring potentially risky security behaviour. Ultimately, future work seeks to implement an affective feedback mechanism within the browser extension with the aim of improving security awareness.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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  • 26
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    Algorithms, Vol. 7, Pages 444-455: A Novel Contrast Enhancement Technique on Palm Bone Images (2014)
    MDPI Publishing
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    Publication Date: 2014-09-06
    Description: Contrast enhancement plays a fundamental role in image processing. Many histogram-based techniques are widely used for contrast enhancement of given images, due to their simple function and effectiveness. However, the conventional histogram equalization (HE) methods result in excessive contrast enhancement, which causes natural looking and satisfactory results for a variety of low contrast images. To solve such problems, a novel multi-histogram equalization technique is proposed to enhance the contrast of the palm bone X-ray radiographs in this paper. For images, the mean-variance analysis method is employed to partition the histogram of the original grey scale image into multiple sub-histograms. These histograms are independently equalized. By using this mean-variance partition method, a proposed multi-histogram equalization technique is employed to achieve the contrast enhancement of the palm bone X-ray radiographs. Experimental results show that the multi-histogram equalization technique achieves a lower average absolute mean brightness error (AMBE) value. The multi-histogram equalization technique simultaneously preserved the mean brightness and enhanced the local contrast of the original image.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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    Future Internet, Vol. 6, Pages 556-584: 7R Data Value Framework for Open Data in Practice: Fusepool (2014)
    MDPI Publishing
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    Publication Date: 2014-09-09
    Description: Based on existing literature, this article makes a case for open (government) data as supporting political efficiency, socio-economic innovation and administrative efficiency, but also finds a lack of measurable impact. It attributes the lack of impact to shortcomings regarding data access (must be efficient) and data usefulness (must be effective). To address these shortcomings, seven key activities that add value to data are identified and are combined into the 7R Data Value Framework, which is an applied methodology for linked data to systematically address both technical and social shortcomings. The 7R Data Value Framework is then applied to the international Fusepool project that develops a set of integrated software components to ease the publishing of open data based on linked data and associated best practices. Real-life applications for the Dutch Parliament and the Libraries of Free University of Berlin are presented, followed by a concluding discussion.
    Electronic ISSN: 1999-5903
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    Algorithms, Vol. 7, Pages 456-470: A Fovea Localization Scheme Using Vessel Origin-Based Parabolic Model (2014)
    MDPI Publishing
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    Publication Date: 2014-09-11
    Description: At the center of the macula, fovea plays an important role in computer-aided diagnosis. To locate the fovea, this paper proposes a vessel origin (VO)-based parabolic model, which takes the VO as the vertex of the parabola-like vasculature. Image processing steps are applied to accurately locate the fovea on retinal images. Firstly, morphological gradient and the circular Hough transform are used to find the optic disc. The structure of the vessel is then segmented with the line detector. Based on the characteristics of the VO, four features of VO are extracted, following the Bayesian classification procedure. Once the VO is identified, the VO-based parabolic model will locate the fovea. To find the fittest parabola and the symmetry axis of the retinal vessel, an Shift and Rotation (SR)-Hough transform that combines the Hough transform with the shift and rotation of coordinates is presented. Two public databases of retinal images, DRIVE and STARE, are used to evaluate the proposed method. The experiment results show that the average Euclidean distances between the located fovea and the fovea marked by experts in two databases are 9.8 pixels and 30.7 pixels, respectively. The results are stronger than other methods and thus provide a better macular detection for further disease discovery.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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    Future Internet, Vol. 6, Pages 584-596: Digital Forensics to Intelligent Forensics (2014)
    MDPI Publishing
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    Publication Date: 2014-09-13
    Description: In this paper we posit that current investigative techniques—particularly as deployed by law enforcement, are becoming unsuitable for most types of crime investigation. The growth in cybercrime and the complexities of the types of the cybercrime coupled with the limitations in time and resources, both computational and human, in addressing cybercrime put an increasing strain on the ability of digital investigators to apply the processes of digital forensics and digital investigations to obtain timely results. In order to combat the problems, there is a need to enhance the use of the resources available and move beyond the capabilities and constraints of the forensic tools that are in current use. We argue that more intelligent techniques are necessary and should be used proactively. The paper makes the case for the need for such tools and techniques, and investigates and discusses the opportunities afforded by applying principles and procedures of artificial intelligence to digital forensics intelligence and to intelligent forensics and suggests that by applying new techniques to digital investigations there is the opportunity to address the challenges of the larger and more complex domains in which cybercrimes are taking place.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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    Future Internet, Vol. 6, Pages 773-799: Inside Technology: Opening the Black Box of Health-Website Configuration and Content Management (2014)
    MDPI Publishing
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    Publication Date: 2014-12-11
    Description: Given the existing divide related to Internet skills and types of Internet use, it is safe to assume that a large proportion of the population uses the Internet for health purposes in a partially productive fashion. We suggest that in addition to user characteristics, another factor that inhibits productive Internet use, and thus contributes to the existing gap, is related to the ways in which the technology is configured. The goal of this study was to explore the processes that webmasters and content managers use for constructing and producing, or selecting content, for health websites. Interviews conducted with 23 website builders and managers of websites that represent public and non-public health organizations revealed that they do not plan or conduct activities for content needs elicitation, either in the design stage or on an ongoing basis. Rather, these professionals rely on a “self-embodiment” standard, whereby their and their cohorts’ expectations determine the quality and functionality of the websites’ structure and content. Hence, target groups beyond their social sphere are disregarded, and instead of new opportunities, new cleavages are created. We recommended that government, public and non-public stakeholders work to establish construction standards, to ensure that health websites meet the needs of varied end-user populations.
    Electronic ISSN: 1999-5903
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    Algorithms, Vol. 7, Pages 663-684: COOBBO: A Novel Opposition-Based Soft Computing Algorithm for TSP Problems (2014)
    MDPI Publishing
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    Publication Date: 2014-12-13
    Description: In this paper, we propose a novel definition of opposite path. Its core feature is that the sequence of candidate paths and the distances between adjacent nodes in the tour are considered simultaneously. In a sense, the candidate path and its corresponding opposite path have the same (or similar at least) distance to the optimal path in the current population. Based on an accepted framework for employing opposition-based learning, Oppositional Biogeography-Based Optimization using the Current Optimum, called COOBBO algorithm, is introduced to solve traveling salesman problems. We demonstrate its performance on eight benchmark problems and compare it with other optimization algorithms. Simulation results illustrate that the excellent performance of our proposed algorithm is attributed to the distinct definition of opposite path. In addition, its great strength lies in exploitation for enhancing the solution accuracy, not exploration for improving the population diversity. Finally, by comparing different version of COOBBO, another conclusion is that each successful opposition-based soft computing algorithm needs to adjust and remain a good balance between backward adjacent node and forward adjacent node.
    Electronic ISSN: 1999-4893
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    Algorithms, Vol. 7, Pages 538-553: Predicting Student Academic Performance: A Comparison of Two Meta-Heuristic Algorithms Inspired by Cuckoo Birds for Training Neural Networks (2014)
    MDPI Publishing
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    Publication Date: 2014-10-17
    Description: Predicting student academic performance with a high accuracy facilitates admission decisions and enhances educational services at educational institutions. This raises the need to propose a model that predicts student performance, based on the results of standardized exams, including university entrance exams, high school graduation exams, and other influential factors. In this study, an approach to the problem based on the artificial neural network (ANN) with the two meta-heuristic algorithms inspired by cuckoo birds and their lifestyle, namely, Cuckoo Search (CS) and Cuckoo Optimization Algorithm (COA) is proposed. In particular, we used previous exam results and other factors, such as the location of the student’s high school and the student’s gender as input variables, and predicted the student academic performance. The standard CS and standard COA were separately utilized to train the feed-forward network for prediction. The algorithms optimized the weights between layers and biases of the neuron network. The simulation results were then discussed and analyzed to investigate the prediction ability of the neural network trained by these two algorithms. The findings demonstrated that both CS and COA have potential in training ANN and ANN-COA obtained slightly better results for predicting student academic performance in this case. It is expected that this work may be used to support student admission procedures and strengthen the service system in educational institutions.
    Electronic ISSN: 1999-4893
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    Algorithms, Vol. 7, Pages 523-537: Multi-Sensor Building Fire Alarm System with Information Fusion Technology Based on D-S Evidence Theory (2014)
    MDPI Publishing
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    Publication Date: 2014-10-15
    Description: Multi-sensor and information fusion technology based on Dempster-Shafer evidence theory is applied in the system of a building fire alarm to realize early detecting and alarming. By using a multi-sensor to monitor the parameters of the fire process, such as light, smoke, temperature, gas and moisture, the range of fire monitoring in space and time is expanded compared with a single-sensor system. Then, the D-S evidence theory is applied to fuse the information from the multi-sensor with the specific fire model, and the fire alarm is more accurate and timely. The proposed method can avoid the failure of the monitoring data effectively, deal with the conflicting evidence from the multi-sensor robustly and improve the reliability of fire warning significantly.
    Electronic ISSN: 1999-4893
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    Algorithms, Vol. 7, Pages 510-522: A CR Spectrum Allocation Algorithm in Smart Grid Wireless Sensor Network (2014)
    MDPI Publishing
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    Publication Date: 2014-10-14
    Description: Cognitive radio (CR) method was introduced in smart grid communication systems to resolve potential maladies such as the coexistence of heterogeneous networks, overloaded data flow, diversity in data structures, and unstable quality of service (QOS). In this paper, a cognitive spectrum allocation algorithm based on non-cooperative game theory is proposed. The CR spectrum allocation model was developed by modifying the traditional game model via the insertion of a time variable and a critical function. The computing simulation result shows that the improved spectrum allocation algorithm can achieve stable spectrum allocation strategies and avoid the appearance of multi-Nash equilibrium at the expense of certain sacrifices in the system utility. It is suitable for application in distributed cognitive networks in power grids, thus contributing to the improvement of the isomerism and data capacity of power communication systems.
    Electronic ISSN: 1999-4893
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    Future Internet, Vol. 6, Pages 397-413: Privacy and Open Government (2014)
    MDPI Publishing
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    Publication Date: 2014-06-19
    Description: The public-oriented goals of the open government movement promise increased transparency and accountability of governments, enhanced citizen engagement and participation, improved service delivery, economic development and the stimulation of innovation. In part, these goals are to be achieved by making more and more government information public in reusable formats and under open licences. This paper identifies three broad privacy challenges raised by open government. The first is how to balance privacy with transparency and accountability in the context of “public” personal information. The second challenge flows from the disruption of traditional approaches to privacy based on a collapse of the distinctions between public and private sector actors. The third challenge is that of the potential for open government data—even if anonymized—to contribute to the big data environment in which citizens and their activities are increasingly monitored and profiled.
    Electronic ISSN: 1999-5903
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    Algorithms, Vol. 7, Pages 376-396: A Hybrid Metaheuristic Approach for Minimizing the Total Flow Time in A Flow Shop Sequence Dependent Group Scheduling Problem (2014)
    MDPI Publishing
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    Publication Date: 2014-07-15
    Description: Production processes in Cellular Manufacturing Systems (CMS) often involve groups of parts sharing the same technological requirements in terms of tooling and setup. The issue of scheduling such parts through a flow-shop production layout is known as the Flow-Shop Group Scheduling (FSGS) problem or, whether setup times are sequence-dependent, the Flow-Shop Sequence-Dependent Group Scheduling (FSDGS) problem. This paper addresses the FSDGS issue, proposing a hybrid metaheuristic procedure integrating features from Genetic Algorithms (GAs) and Biased Random Sampling (BRS) search techniques with the aim of minimizing the total flow time, i.e., the sum of completion times of all jobs. A well-known benchmark of test cases, entailing problems with two, three, and six machines, is employed for both tuning the relevant parameters of the developed procedure and assessing its performances against two metaheuristic algorithms recently presented by literature. The obtained results and a properly arranged ANOVA analysis highlight the superiority of the proposed approach in tackling the scheduling problem under investigation.
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    Algorithms, Vol. 7, Pages 166-185: Pareto Optimization or Cascaded Weighted Sum: A Comparison of Concepts (2014)
    MDPI Publishing
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    Publication Date: 2014-03-22
    Description: Looking at articles or conference papers published since the turn of the century, Pareto optimization is the dominating assessment method for multi-objective nonlinear optimization problems. However, is it always the method of choice for real-world applications, where either more than four objectives have to be considered, or the same type of task is repeated again and again with only minor modifications, in an automated optimization or planning process? This paper presents a classification of application scenarios and compares the Pareto approach with an extended version of the weighted sum, called cascaded weighted sum, for the different scenarios. Its range of application within the field of multi-objective optimization is discussed as well as its strengths and weaknesses.
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    Algorithms, Vol. 7, Pages 328-338: Economic Dispatch Using Modified Bat Algorithm (2014)
    MDPI Publishing
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    Publication Date: 2014-07-04
    Description: Economic dispatch is an important non-linear optimization task in power systems. In this process, the total power demand is distributed amongst the generating units such that each unit satisfies its generation limit constraints and the cost of power production is minimized. This paper presents an over view of three optimization algorithms namely real coded genetic algorithm, particle swarm optimization and a relatively new optimization technique called bat algorithm. This study will further propose modifications to the original bat. Simulations are carried out for two test cases. First is a six-generator power system with a simplified convex objective function. The second test case is a five-generator system with a non-convex objective function. Finally the results of the modified algorithm are compared with the results of genetic algorithm, particle swarm and the original bat algorithm. The results demonstrate the improvement in the Bat Algorithm.
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    Algorithms, Vol. 7, Pages 295-327: Solving the Examination Timetabling Problem in GPUs (2014)
    MDPI Publishing
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    Publication Date: 2014-07-04
    Description: The examination timetabling problem belongs to the class of combinatorial optimization problems and is of great importance for every University. In this paper, a hybrid evolutionary algorithm running on a GPU is employed to solve the examination timetabling problem. The hybrid evolutionary algorithm proposed has a genetic algorithm component and a greedy steepest descent component. The GPU computational capabilities allow the use of very large population sizes, leading to a more thorough exploration of the problem solution space. The GPU implementation, depending on the size of the problem, is up to twenty six times faster than the identical single-threaded CPU implementation of the algorithm. The algorithm is evaluated with the well known Toronto datasets and compares well with the best results found in the bibliography. Moreover, the selection of the encoding of the chromosomes and the tournament selection size as the population grows are examined and optimized. The compressed sparse row format is used for the conflict matrix and was proven essential to the process, since most of the datasets have a small conflict density, which translates into an extremely sparse matrix.
    Electronic ISSN: 1999-4893
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    Algorithms, Vol. 7, Pages 145-165: The Minimum Scheduling Time for Convergecast in Wireless Sensor Networks (2014)
    MDPI Publishing
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    Publication Date: 2014-03-18
    Description: We study the scheduling problem for data collection from sensor nodes to the sink node in wireless sensor networks, also referred to as the convergecast problem. The convergecast problem in general network topology has been proven to be NP-hard. In this paper, we propose our heuristic algorithm (finding the minimum scheduling time for convergecast (FMSTC)) for general network topology and evaluate the performance by simulation. The results of the simulation showed that the number of time slots to reach the sink node decreased with an increase in the power. We compared the performance of the proposed algorithm to the optimal time slots in a linear network topology. The proposed algorithm for convergecast in a general network topology has 2.27 times more time slots than that of a linear network topology. To the best of our knowledge, the proposed method is the first attempt to apply the optimal algorithm in a linear network topology to a general network topology.
    Electronic ISSN: 1999-4893
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    Future Internet, Vol. 6, Pages 155-170: A Novel DOA Estimation Algorithm Using Array Rotation Technique (2014)
    MDPI Publishing
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    Publication Date: 2014-03-18
    Description: The performance of traditional direction of arrival (DOA) estimation algorithm based on uniform circular array (UCA) is constrained by the array aperture. Furthermore, the array requires more antenna elements than targets, which will increase the size and weight of the device and cause higher energy loss. In order to solve these issues, a novel low energy algorithm utilizing array base-line rotation for multiple targets estimation is proposed. By rotating two elements and setting a fixed time delay, even the number of elements is selected to form a virtual UCA. Then, the received data of signals will be sampled at multiple positions, which improves the array elements utilization greatly. 2D-DOA estimation of the rotation array is accomplished via multiple signal classification (MUSIC) algorithms. Finally, the Cramer-Rao bound (CRB) is derived and simulation results verified the effectiveness of the proposed algorithm with high resolution and estimation accuracy performance. Besides, because of the significant reduction of array elements number, the array antennas system is much simpler and less complex than traditional array.
    Electronic ISSN: 1999-5903
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    Future Internet, Vol. 6, Pages 203-222: Routing Diverse Evacuees with the Cognitive Packet Network Algorithm (2014)
    MDPI Publishing
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    Publication Date: 2014-04-18
    Description: Regarding mobility, health conditions and personal preferences, evacuees can be categorized into different classes in realistic environments. Previous emergency navigation algorithms that direct evacuees with a single decision rule cannot fulfil civilians’ distinct service requirements and increase the likelihood of inducing destructive crowd behaviours, such as clogging, pushing and trampling, due to diverse mobility. This paper explores a distributed emergency navigation algorithm that employs the cognitive packet network concept to tailor different quality of service needs to different categories of evacuees. In addition, a congestion-aware algorithm is presented to predict the future congestion degree of a path with respect to the observed population density, arrival rate and service rate of each route segment. Experiments are implemented in a simulated environment populated with autonomous agents. Results show that our algorithm can increase the number of survivors while providing improved quality of service.
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    Algorithms, Vol. 7, Pages 186-187: Editorial: Special Issue on Algorithms for Sequence Analysis and Storage (2014)
    MDPI Publishing
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    Publication Date: 2014-03-26
    Description: This special issue of Algorithms is dedicated to approaches to biological sequence analysis that have algorithmic novelty and potential for fundamental impact in methods used for genome research.
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    Algorithms, Vol. 7, Pages 203-205: Editorial: Special Issue on Matching under Preferences (2014)
    MDPI Publishing
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    Publication Date: 2014-04-09
    Description: This special issue of Algorithms is devoted to the study of matching problems involving ordinal preferences from the standpoint of algorithms and complexity.
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    Future Internet, Vol. 6, Pages 223-241: An Ontology of the Appropriate Assessment of Municipal Master Plans Related to Sardinia (Italy) (2014)
    MDPI Publishing
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    Publication Date: 2014-04-24
    Description: This paper discusses some key points related to the ontology of the “appropriate assessment” [1] procedure concerning plans significantly affecting Natura 2000 sites. We study this ontology by discussing its implementation into the adjustment process of the master plans of the regional municipalities of Sardinia (Italy) to the Regional Landscape Plan (RLP) and put as evidence some important general observations, coming from the case study, concerning the utility and effectiveness of the ontological conceptual framework in order to help planners and decision-makers understand and structure the assessment process of plans.
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    Future Internet, Vol. 6, Pages 242-260: Exploiting Multimedia in Creating and Analysing Multimedia Web Archives (2014)
    MDPI Publishing
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    Publication Date: 2014-04-25
    Description: The data contained on the web and the social web are inherently multimedia and consist of a mixture of textual, visual and audio modalities. Community memories embodied on the web and social web contain a rich mixture of data from these modalities. In many ways, the web is the greatest resource ever created by human-kind. However, due to the dynamic and distributed nature of the web, its content changes, appears and disappears on a daily basis. Web archiving provides a way of capturing snapshots of (parts of) the web for preservation and future analysis. This paper provides an overview of techniques we have developed within the context of the EU funded ARCOMEM (ARchiving COmmunity MEMories) project to allow multimedia web content to be leveraged during the archival process and for post-archival analysis. Through a set of use cases, we explore several practical applications of multimedia analytics within the realm of web archiving, web archive analysis and multimedia data on the web in general.
    Electronic ISSN: 1999-5903
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    Algorithms, Vol. 7, Pages 621-634: Neural Networks for Muscle Forces Prediction in Cycling (2014)
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    Publication Date: 2014-11-14
    Description: This paper documents the research towards the development of a system based on Artificial Neural Networks to predict muscle force patterns of an athlete during cycling. Two independent inverse problems must be solved for the force estimation: evaluation of the kinematic model and evaluation of the forces distribution along the limb. By solving repeatedly the two inverse problems for different subjects and conditions, a training pattern for an Artificial Neural Network was created. Then, the trained network was validated against an independent validation set, and compared to evaluate agreement between the two alternative approaches using Bland-Altman method. The obtained neural network for the different test patterns yields a normalized error well below 1% and the Bland-Altman plot shows a considerable correlation between the two methods. The new approach proposed herein allows a direct and fast computation for the inverse dynamics of a cyclist, opening the possibility of integrating such algorithm in a real time environment such as an embedded application.
    Electronic ISSN: 1999-4893
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    Future Internet, Vol. 6, Pages 717-734: Using Multilevel Analysis to Examine the Relationship between Upper Secondary Students Internet Safety Awareness, Social Background and Academic Aspirations (2014)
    MDPI Publishing
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    Publication Date: 2014-11-15
    Description: Since 2009, most Norwegian students in upper secondary have had access to their own personal computer at school. Hence, with the increased access to technology, the importance of online connectedness has increased for adolescents’ social interaction and communication. It is, therefore, important to identify and understand the concept of Internet safety among upper secondary school students. A total of 4216 students from 238 classrooms in 23 upper secondary schools completed an Internet safety assessment. The aim of the study was to operationalize and measure Internet safety in a school context, and to further examine the factors predicting students’ Internet safety awareness and responsibility. Our analysis revealed substantial variation in Internet safety awareness between schools, classrooms and students. Overall, the findings indicate that students’ social backgrounds are determining for their development and understanding of Internet safety awareness.
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    Algorithms, Vol. 7, Pages 471-491: Applying a Dynamic Resource Supply Model in a Smart Grid (2014)
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    Publication Date: 2014-09-23
    Description: Dynamic resource supply is a complex issue to resolve in a cyber-physical system (CPS). In our previous work, a resource model called the dynamic resource supply model (DRSM) has been proposed to handle resources specification, management and allocation in CPS. In this paper, we are integrating the DRSM with service-oriented architecture and applying it to a smart grid (SG), one of the most complex CPS examples. We give the detailed design of the SG for electricity charging request and electricity allocation between plug-in hybrid electric vehicles (PHEV) and DRSM through the Android system. In the design, we explain a mechanism for electricity consumption with data collection and re-allocation through ZigBee network. In this design, we verify the correctness of this resource model for expected electricity allocation.
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    Future Internet, Vol. 6, Pages 498-517: Assessing Social Value in Open Data Initiatives: A Framework (2014)
    MDPI Publishing
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    Publication Date: 2014-08-20
    Description: Open data initiatives are characterized, in several countries, by a great extension of the number of data sets made available for access by public administrations, constituencies, businesses and other actors, such as journalists, international institutions and academics, to mention a few. However, most of the open data sets rely on selection criteria, based on a technology-driven perspective, rather than a focus on the potential public and social value of data to be published. Several experiences and reports confirm this issue, such as those of the Open Data Census. However, there are also relevant best practices. The goal of this paper is to investigate the different dimensions of a framework suitable to support public administrations, as well as constituencies, in assessing and benchmarking the social value of open data initiatives. The framework is tested on three initiatives, referring to three different countries, Italy, the United Kingdom and Tunisia. The countries have been selected to provide a focus on European and Mediterranean countries, considering also the difference in legal frameworks (civic law vs. common law countries).
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    Future Internet, Vol. 6, Pages 518-541: ARCOMEM Crawling Architecture (2014)
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    Publication Date: 2014-08-20
    Description: The World Wide Web is the largest information repository available today. However, this information is very volatile and Web archiving is essential to preserve it for the future. Existing approaches to Web archiving are based on simple definitions of the scope of Web pages to crawl and are limited to basic interactions with Web servers. The aim of the ARCOMEM project is to overcome these limitations and to provide flexible, adaptive and intelligent content acquisition, relying on social media to create topical Web archives. In this article, we focus on ARCOMEM’s crawling architecture. We introduce the overall architecture and we describe its modules, such as the online analysis module, which computes a priority for the Web pages to be crawled, and the Application-Aware Helper which takes into account the type of Web sites and applications to extract structure from crawled content. We also describe a large-scale distributed crawler that has been developed, as well as the modifications we have implemented to adapt Heritrix, an open source crawler, to the needs of the project. Our experimental results from real crawls show that ARCOMEM’s crawling architecture is effective in acquiring focused information about a topic and leveraging the information from social media.
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    Algorithms, Vol. 7, Pages 405-417: Seminal Quality Prediction Using Clustering-Based Decision Forests (2014)
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    Publication Date: 2014-08-12
    Description: Prediction of seminal quality with statistical learning tools is an emerging methodology in decision support systems in biomedical engineering and is very useful in early diagnosis of seminal patients and selection of semen donors candidates. However, as is common in medical diagnosis, seminal quality prediction faces the class imbalance problem. In this paper, we propose a novel supervised ensemble learning approach, namely Clustering-Based Decision Forests, to tackle unbalanced class learning problem in seminal quality prediction. Experiment results on real fertility diagnosis dataset have shown that Clustering-Based Decision Forests outperforms decision tree, Support Vector Machines, random forests, multilayer perceptron neural networks and logistic regression by a noticeable margin. Clustering-Based Decision Forests can also be used to evaluate variables’ importance and the top five important factors that may affect semen concentration obtained in this study are age, serious trauma, sitting time, the season when the semen sample is produced, and high fevers in the last year. The findings could be helpful in explaining seminal concentration problems in infertile males or pre-screening semen donor candidates.
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    Future Internet, Vol. 6, Pages 457-481: Should I Care about Your Opinion? Detection of Opinion Interestingness and Dynamics in Social Media (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-08-14
    Description: In this paper, we describe a set of reusable text processing components for extracting opinionated information from social media, rating it for interestingness, and for detecting opinion events. We have developed applications in GATE to extract named entities, terms and events and to detect opinions about them, which are then used as the starting point for opinion event detection. The opinions are then aggregated over larger sections of text, to give some overall sentiment about topics and documents, and also some degree of information about interestingness based on opinion diversity. We go beyond traditional opinion mining techniques in a number of ways: by focusing on specific opinion-target extraction related to key terms and events, by examining and dealing with a number of specific linguistic phenomena, by analysing and visualising opinion dynamics over time, and by aggregating the opinions in different ways for a more flexible view of the information contained in the documents.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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    Algorithms, Vol. 7, Pages 418-428: Target Channel Visiting Order Design Using Particle Swarm Optimization for Spectrum Handoff in Cognitive Radio Networks (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-08-19
    Description: In a dynamic spectrum access network, when a primary user (licensed user) reappears on the current channel, cognitive radios (CRs) need to vacate the channel and reestablish a communications link on some other channel to avoid interference to primary users, resulting in spectrum handoff. This paper studies the problem of designing target channel visiting order for spectrum handoff to minimize expected spectrum handoff delay. A particle swarm optimization (PSO) based algorithm is proposed to solve the problem. Simulation results show that the proposed algorithm performs far better than random target channel visiting scheme. The solutions obtained by PSO are very close to the optimal solution which further validates the effectiveness of the proposed method.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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    Algorithms, Vol. 7, Pages 429-443: ℓ1 Major Component Detection and Analysis (ℓ1 MCDA) in Three and Higher Dimensional Spaces (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-08-20
    Description: Based on the recent development of two dimensional ℓ1 major component detection and analysis (ℓ1 MCDA), we develop a scalable ℓ1 MCDA in the n-dimensional space to identify the major directions of star-shaped heavy-tailed statistical distributions with irregularly positioned “spokes” and “clutters”. In order to achieve robustness and efficiency, the proposed ℓ1 MCDA in n-dimensional space adopts a two-level median fit process in a local neighbor of a given direction in each iteration. Computational results indicate that in terms of accuracy ℓ1 MCDA is competitive with two well-known PCAs when there is only one major direction in the data, and ℓ1 MCDA can further determine multiple major directions of the n-dimensional data from superimposed Gaussians or heavy-tailed distributions without and with patterned artificial outliers. With the ability to recover complex spoke structures with heavy-tailed noise and clutter in the data, ℓ1 MCDA has potential to generate better semantics than other methods.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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    Future Internet, Vol. 6, Pages 482-497: Rikki Don’t Lose That Number: Enumerated Human Rights in a Society of Infinite Connections (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-08-20
    Description: The international Human Rights regime acknowledges a certain number of rights. That number, albeit increasing since its inception, does not seem able to keep up with the pace of modern technology. Human rights today are not only exercised in the tangible world; they are also exercised on a daily basis in a world of ubiquitous computing–as such they can be easily breached with a mere click of a button. To make matters worse, these rights are controlled largely by multinational corporations that have little regard for their value. In this paper we will attempt to explore the difficulties the global human rights regime faces today, the challenge that is its enforcement, and whether it has come to a standstill in an age where connections grow faster than the rule of law.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
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    Algorithms, Vol. 7, Pages 363-375: Pressure Model of Control Valve Based on LS-SVM with the Fruit Fly Algorithm (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-07-12
    Description: Control valve is a kind of essential terminal control component which is hard to model by traditional methodologies because of its complexity and nonlinearity. This paper proposes a new modeling method for the upstream pressure of control valve using the least squares support vector machine (LS-SVM), which has been successfully used to identify nonlinear system. In order to improve the modeling performance, the fruit fly optimization algorithm (FOA) is used to optimize two critical parameters of LS-SVM. As an example, a set of actual production data from a controlling system of chlorine in a salt chemistry industry is applied. The validity of LS-SVM modeling method using FOA is verified by comparing the predicted results with the actual data with a value of MSE 2.474 × 10−3. Moreover, it is demonstrated that the initial position of FOA does not affect its optimal ability. By comparison, simulation experiments based on PSO algorithm and the grid search method are also carried out. The results show that LS-SVM based on FOA has equal performance in prediction accuracy. However, from the respect of calculation time, FOA has a significant advantage and is more suitable for the online prediction.
    Electronic ISSN: 1999-4893
    Topics: Computer Science
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    Science for lasting peace (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-08-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Aug 15;345(6198):715. doi: 10.1126/science.1259611.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25124402" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Ecology. What's killing the reindeer? (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2014 Nov 7;346(6210):685. doi: 10.1126/science.346.6210.685.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25378600" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carnivory ; *Conservation of Natural Resources ; Food Chain ; Lynx ; Mustelidae ; Norway ; Population Dynamics ; *Reindeer
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Ebola's perfect storm (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-09-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piot, Peter -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1221. doi: 10.1126/science.1260695.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Peter Piot is director and professor of Global Health at the London School of Hygiene & Tropical Medicine, London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214580" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Western/epidemiology ; Disease Outbreaks/*prevention & control ; Ebola Vaccines ; Hemorrhagic Fever, Ebola/*epidemiology/*prevention & control ; Humans ; International Cooperation ; Poverty
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Materials design. Folding structures out of flat materials (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉You, Zhong -- New York, N.Y. -- Science. 2014 Aug 8;345(6197):623-4. doi: 10.1126/science.1257841.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Engineering Science, University of Oxford, Parks Road, Oxford, OX3 0PL, UK. zhong.you@eng.ox.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25104372" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    RNA events. Cas9 targeting and the CRISPR revolution (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-05-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barrangou, Rodolphe -- New York, N.Y. -- Science. 2014 May 16;344(6185):707-8. doi: 10.1126/science.1252964.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA. rbarran@ncsu.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24833384" target="_blank"〉PubMed〈/a〉
    Keywords: Caspase 9/genetics/*metabolism ; *Clustered Regularly Interspaced Short Palindromic Repeats ; *DNA Cleavage ; Gene Targeting/*methods ; Genetic Engineering/*methods ; RNA, Guide/*genetics ; Streptococcus pyogenes/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Ultrafast switching to a stable hidden quantum state in an electronic crystal (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-12
    Description: Hidden states of matter may be created if a system out of equilibrium follows a trajectory to a state that is inaccessible or does not exist under normal equilibrium conditions. We found such a hidden (H) electronic state in a layered dichalcogenide crystal of 1T-TaS2 (the trigonal phase of tantalum disulfide) reached as a result of a quench caused by a single 35-femtosecond laser pulse. In comparison to other states of the system, the H state exhibits a large drop of electrical resistance, strongly modified single-particle and collective-mode spectra, and a marked change of optical reflectivity. The H state is stable until a laser pulse, electrical current, or thermal erase procedure is applied, causing it to revert to the thermodynamic ground state.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stojchevska, L -- Vaskivskyi, I -- Mertelj, T -- Kusar, P -- Svetin, D -- Brazovskii, S -- Mihailovic, D -- New York, N.Y. -- Science. 2014 Apr 11;344(6180):177-80. doi: 10.1126/science.1241591.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Complex Matter, Jozef Stefan Institute, Jamova 39, Ljubljana SI-1000, Slovenia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24723607" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Environmental Economics. Using and improving the social cost of carbon (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-12-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pizer, William -- Adler, Matthew -- Aldy, Joseph -- Anthoff, David -- Cropper, Maureen -- Gillingham, Kenneth -- Greenstone, Michael -- Murray, Brian -- Newell, Richard -- Richels, Richard -- Rowell, Arden -- Waldhoff, Stephanie -- Wiener, Jonathan -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1189-90. doi: 10.1126/science.1259774.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Duke University, Durham, NC 27708, USA. Resources for the Future, Washington, DC 20036, USA. william.pizer@duke.edu. ; Duke University, Durham, NC 27708, USA. ; Resources for the Future, Washington, DC 20036, USA. Harvard University, Cambridge, MA 02138, USA. ; University of California Berkeley, Berkeley, CA 94720, USA. ; Resources for the Future, Washington, DC 20036, USA. University of Maryland, College Park, MD 20742, USA. ; Yale University, New Haven, CT 06511, USA. ; University of Chicago, Chicago, IL 60637, USA. ; Duke University, Durham, NC 27708, USA. Resources for the Future, Washington, DC 20036, USA. ; Electric Power Research Institute, Washington, DC 20036, USA. ; University of Illinois, Champaign, IL 61801, USA. ; Pacific Northwest National Laboratory, Richland, WA 99354, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477446" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon Dioxide/*economics ; Climate Change/*economics ; Cost-Benefit Analysis ; *Environment ; Models, Economic ; Socioeconomic Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Conservation biology. The coming salamander plague (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2014 Oct 31;346(6209):530-1. doi: 10.1126/science.346.6209.530.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25359941" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chytridiomycota ; Communicable Diseases, Emerging/*veterinary ; *Endangered Species ; Mycoses/*veterinary ; Urodela/*microbiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Genetics. A genomic road map for complex human disease (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-03-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gregersen, Peter K -- New York, N.Y. -- Science. 2014 Mar 7;343(6175):1087-8. doi: 10.1126/science.1251426.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Robert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 110430, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24604188" target="_blank"〉PubMed〈/a〉
    Keywords: Crohn Disease/*genetics ; Dendritic Cells/*immunology ; Female ; Gene Expression Regulation/*immunology ; *Gene-Environment Interaction ; *Genetic Predisposition to Disease ; Host-Pathogen Interactions/*genetics ; Humans ; Immunity, Innate/*genetics ; Interferon Regulatory Factor-7/*genetics ; Male ; Monocytes/*immunology ; STAT Transcription Factors/*genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Climate change. Is Atlantic holding Earth's missing heat? (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-08-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2014 Aug 22;345(6199):860-1. doi: 10.1126/science.345.6199.860.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25146261" target="_blank"〉PubMed〈/a〉
    Keywords: *Global Warming ; *Greenhouse Effect ; *Hot Temperature
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    Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-08-26
    Description: Aging-associated cognitive decline is affected by factors produced inside and outside the brain. By using multiorgan genome-wide analysis of aged mice, we found that the choroid plexus, an interface between the brain and the circulation, shows a type I interferon (IFN-I)-dependent gene expression profile that was also found in aged human brains. In aged mice, this response was induced by brain-derived signals, present in the cerebrospinal fluid. Blocking IFN-I signaling within the aged brain partially restored cognitive function and hippocampal neurogenesis and reestablished IFN-II-dependent choroid plexus activity, which is lost in aging. Our data identify a chronic aging-induced IFN-I signature, often associated with antiviral response, at the brain's choroid plexus and demonstrate its negative influence on brain function, thereby suggesting a target for ameliorating cognitive decline in aging.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baruch, Kuti -- Deczkowska, Aleksandra -- David, Eyal -- Castellano, Joseph M -- Miller, Omer -- Kertser, Alexander -- Berkutzki, Tamara -- Barnett-Itzhaki, Zohar -- Bezalel, Dana -- Wyss-Coray, Tony -- Amit, Ido -- Schwartz, Michal -- AG045034/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2014 Oct 3;346(6205):89-93. doi: 10.1126/science.1252945. Epub 2014 Aug 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. ; Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel. ; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. ; Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel. michal.schwartz@weizmann.ac.il ido.amit@weizmann.ac.il. ; Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. michal.schwartz@weizmann.ac.il ido.amit@weizmann.ac.il.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25147279" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/genetics/*pathology ; Animals ; Brain/*physiology ; Choroid Plexus/*metabolism ; *Cognition ; *Gene Expression Regulation ; Hippocampus/cytology ; Interferon Regulatory Factors/*genetics ; Interferon Type I/*physiology ; Mice ; Mice, Transgenic ; Neurogenesis ; Receptors, Interferon/genetics
    Print ISSN: 0036-8075
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    Central cell-derived peptides regulate early embryo patterning in flowering plants (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-12
    Description: Plant embryogenesis initiates with the establishment of an apical-basal axis; however, the molecular mechanisms accompanying this early event remain unclear. Here, we show that a small cysteine-rich peptide family is required for formation of the zygotic basal cell lineage and proembryo patterning in Arabidopsis. EMBRYO SURROUNDING FACTOR 1 (ESF1) peptides accumulate before fertilization in central cell gametes and thereafter in embryo-surrounding endosperm cells. Biochemical and structural analyses revealed cleavage of ESF1 propeptides to form biologically active mature peptides. Further, these peptides act in a non-cell-autonomous manner and synergistically with the receptor-like kinase SHORT SUSPENSOR to promote suspensor elongation through the YODA mitogen-activated protein kinase pathway. Our findings demonstrate that the second female gamete and its sexually derived endosperm regulate early embryonic patterning in flowering plants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Costa, Liliana M -- Marshall, Eleanor -- Tesfaye, Mesfin -- Silverstein, Kevin A T -- Mori, Masashi -- Umetsu, Yoshitaka -- Otterbach, Sophie L -- Papareddy, Ranjith -- Dickinson, Hugh G -- Boutiller, Kim -- VandenBosch, Kathryn A -- Ohki, Shinya -- Gutierrez-Marcos, Jose F -- BB/F008082/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/L003023/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/L003023/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Apr 11;344(6180):168-72. doi: 10.1126/science.1243005.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Sciences, University of Oxford, South Parks Road, OX1 3RB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24723605" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Arabidopsis/*embryology/genetics ; Arabidopsis Proteins/chemistry/genetics/*metabolism ; *Body Patterning ; Endosperm/embryology/genetics ; Flowers/*embryology/genetics ; Gene Duplication ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Plant ; Gene Knockout Techniques ; Interleukin-1 Receptor-Associated Kinases/metabolism ; MAP Kinase Kinase Kinases/metabolism ; Molecular Sequence Data ; Peptides/chemistry/genetics/metabolism ; Seeds/*embryology/genetics
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    Hunting a climate fugitive (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-06-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2014 Jun 27;344(6191):1472-3. doi: 10.1126/science.344.6191.1472.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24970077" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; Atmosphere ; Climate Change ; *Methane ; *Natural Gas ; *Oil and Gas Fields
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Carbon cycle. Sunlight controls water column processing of carbon in arctic fresh waters (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-08-26
    Description: Carbon in thawing permafrost soils may have global impacts on climate change; however, the factors that control its processing and fate are poorly understood. The dominant fate of dissolved organic carbon (DOC) released from soils to inland waters is either complete oxidation to CO2 or partial oxidation and river export to oceans. Although both processes are most often attributed to bacterial respiration, we found that photochemical oxidation exceeds rates of respiration and accounts for 70 to 95% of total DOC processed in the water column of arctic lakes and rivers. At the basin scale, photochemical processing of DOC is about one-third of the total CO2 released from surface waters and is thus an important component of the arctic carbon budget.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cory, Rose M -- Ward, Collin P -- Crump, Byron C -- Kling, George W -- New York, N.Y. -- Science. 2014 Aug 22;345(6199):925-8. doi: 10.1126/science.1253119.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Earth and Environmental Sciences, University of Michigan, Ann Arbor, MI 48109, USA. rmcory@umich.edu. ; Earth and Environmental Sciences, University of Michigan, Ann Arbor, MI 48109, USA. ; Earth, Ocean, and Atmospheric Sciences, Oregon State University, Corvallis, OR 97331, USA. ; Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25146289" target="_blank"〉PubMed〈/a〉
    Keywords: Arctic Regions ; Carbon/*chemistry ; *Carbon Cycle ; Carbon Dioxide/chemistry ; Fresh Water/*chemistry ; Geologic Sediments/chemistry ; Photochemical Processes ; Soil ; *Sunlight ; Wetlands
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Raising the bar (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Jul 4;345(6192):9. doi: 10.1126/science.1257891.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24994623" target="_blank"〉PubMed〈/a〉
    Keywords: Bias (Epidemiology) ; *Editorial Policies ; *Manuscripts as Topic ; Research Design/*statistics & numerical data ; Statistics as Topic/*standards
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-kappaB activation (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-05-17
    Description: A switchlike response in nuclear factor-kappaB (NF-kappaB) activity implies the existence of a threshold in the NF-kappaB signaling module. We show that the CARD-containing MAGUK protein 1 (CARMA1, also called CARD11)-TAK1 (MAP3K7)-inhibitor of NF-kappaB (IkappaB) kinase-beta (IKKbeta) module is a switch mechanism for NF-kappaB activation in B cell receptor (BCR) signaling. Experimental and mathematical modeling analyses showed that IKK activity is regulated by positive feedback from IKKbeta to TAK1, generating a steep dose response to BCR stimulation. Mutation of the scaffolding protein CARMA1 at serine-578, an IKKbeta target, abrogated not only late TAK1 activity, but also the switchlike activation of NF-kappaB in single cells, suggesting that phosphorylation of this residue accounts for the feedback.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shinohara, Hisaaki -- Behar, Marcelo -- Inoue, Kentaro -- Hiroshima, Michio -- Yasuda, Tomoharu -- Nagashima, Takeshi -- Kimura, Shuhei -- Sanjo, Hideki -- Maeda, Shiori -- Yumoto, Noriko -- Ki, Sewon -- Akira, Shizuo -- Sako, Yasushi -- Hoffmann, Alexander -- Kurosaki, Tomohiro -- Okada-Hatakeyama, Mariko -- 5R01CA141722/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2014 May 16;344(6185):760-4. doi: 10.1126/science.1250020.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. ; Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Institute for Quantitative and Computational Biosciences (QC Bio) and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90025, USA. ; Laboratory for Cell Signaling Dynamics, RIKEN Quantitative Biology Center (QBiC), 6-2-3, Furuedai, Suita, Osaka 565-0874, Japan. Cellular Informatics Laboratory, RIKEN, 2-1 Hirosawa, Wako 351-0198, Japan. ; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. ; Graduate School of Engineering, Tottori University 4-101, Koyama-minami, Tottori 680-8552, Japan. ; Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. ; Cellular Informatics Laboratory, RIKEN, 2-1 Hirosawa, Wako 351-0198, Japan. ; Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Institute for Quantitative and Computational Biosciences (QC Bio) and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90025, USA. ahoffmann@ucla.edu kurosaki@rcai.riken.jp marikoh@rcai.riken.jp. ; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. ahoffmann@ucla.edu kurosaki@rcai.riken.jp marikoh@rcai.riken.jp. ; Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. ahoffmann@ucla.edu kurosaki@rcai.riken.jp marikoh@rcai.riken.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24833394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/metabolism ; CARD Signaling Adaptor Proteins/genetics/*metabolism ; Cell Line ; Chickens ; Feedback, Physiological ; Guanylate Cyclase/genetics/*metabolism ; I-kappa B Kinase/*metabolism ; MAP Kinase Kinase Kinases/genetics/*metabolism ; Mice ; Mice, Knockout ; Mutation ; NF-kappa B/*agonists ; Phosphorylation ; Receptors, Antigen, B-Cell/genetics/*metabolism ; Serine/genetics/metabolism ; Signal Transduction
    Print ISSN: 0036-8075
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    Human evolution. How we tamed ourselves--and became modern (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):405-6. doi: 10.1126/science.346.6208.405.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342776" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Domestic/*psychology ; *Biological Evolution ; *Cooperative Behavior ; Female ; Hominidae/anatomy & histology/psychology ; Humans ; Male ; Skull/*anatomy & histology ; Testosterone/metabolism ; Tooth/anatomy & histology
    Print ISSN: 0036-8075
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    Public health. Measuring the path toward malaria elimination (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-06-14
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340075/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340075/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Churcher, Thomas S -- Cohen, Justin M -- Novotny, Joseph -- Ntshalintshali, Nyasatu -- Kunene, Simon -- Cauchemez, Simon -- MR/K010174/1/Medical Research Council/United Kingdom -- U54 GM088491/GM/NIGMS NIH HHS/ -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Jun 13;344(6189):1230-2. doi: 10.1126/science.1251449.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Infectious Disease Epidemiology, Imperial College London, London, UK. ; Clinton Health Access Initiative, Boston, MA 02127, USA. ; Clinton Health Access Initiative, Boston, MA 02127, USA. Global Health Group, University of California, San Francisco, CA 94143, USA. ; National Malaria Control Program, Manzini, Swaziland. ; Department of Infectious Disease Epidemiology, Imperial College London, London, UK. Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Paris, France. simon.cauchemez@pasteur.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24926005" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Culicidae/parasitology ; Disease Eradication/*methods/*trends ; Endemic Diseases/*prevention & control ; Female ; *Global Health ; Humans ; Insect Vectors/parasitology ; Malaria/epidemiology/*prevention & control/transmission ; Mosquito Control/methods ; Seasons
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    Physics. The advantages of extra entanglement (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Widera, Artur -- New York, N.Y. -- Science. 2014 Apr 11;344(6180):160-1. doi: 10.1126/science.1251472.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physics Department and Research Center OPTIMAS, Kaiserslautern University, Erwin-Schrodinger-Str., 67663 Kaiserslautern, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24723603" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Environment. 25 years after the Exxon Valdez, where are the herring? (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pegau, W Scott -- New York, N.Y. -- Science. 2014 Mar 28;343(6178):1416. doi: 10.1126/science.343.6178.1416.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24675929" target="_blank"〉PubMed〈/a〉
    Keywords: Alaska ; Animals ; *Disasters ; *Fishes ; *Petroleum Pollution
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-06-28
    Description: The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. Approximately 50% of the infected cells in one patient were from a single clone, and some clones persisted for many years. There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262401/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262401/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maldarelli, F -- Wu, X -- Su, L -- Simonetti, F R -- Shao, W -- Hill, S -- Spindler, J -- Ferris, A L -- Mellors, J W -- Kearney, M F -- Coffin, J M -- Hughes, S H -- 25XS119/PHS HHS/ -- HSSN261200800001E/PHS HHS/ -- R01 CA089441/CA/NCI NIH HHS/ -- R37 CA089441/CA/NCI NIH HHS/ -- Z99 CA999999/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 Jul 11;345(6193):179-83. doi: 10.1126/science.1254194. Epub 2014 Jun 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA. ; Leidos Biomedical Research, Frederick, MD 21702, USA. ; HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA. Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, 20122 Milan, Italy. ; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. ; Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA. ; HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA. hughesst@mail.nih.gov.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24968937" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Retroviral Agents/therapeutic use ; Basic-Leucine Zipper Transcription Factors/*genetics ; Clone Cells/virology ; DNA, Viral/analysis/genetics/metabolism ; Genome, Human ; HIV/genetics/*physiology ; HIV Infections/drug therapy/genetics/*virology ; Humans ; RNA, Viral/analysis/genetics/metabolism ; Transcription Factors/*genetics ; Virus Integration/*genetics ; Virus Latency/*genetics
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    Virology. Getting rid of a persistent troublemaker to cure hepatitis (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shlomai, Amir -- Rice, Charles M -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1212-3. doi: 10.1126/science.1252186.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626921" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antiviral Agents/*pharmacology ; DNA, Circular/*metabolism ; DNA, Viral/*metabolism ; Hepatitis B/*drug therapy ; Hepatitis B virus/*drug effects ; Hepatocytes/*drug effects ; Humans ; Interferon-alpha/*pharmacology ; Lymphotoxin beta Receptor/*agonists
    Print ISSN: 0036-8075
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    The administrator: Jay Walsh (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):29. doi: 10.1126/science.344.6179.29.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700839" target="_blank"〉PubMed〈/a〉
    Keywords: *Administrative Personnel ; Biomedical Research/*economics/organization & administration ; Budgets ; Financing, Government ; Illinois ; National Institutes of Health (U.S.)/economics ; Research Support as Topic/*organization & administration ; United States ; Universities/*economics/organization & administration
    Print ISSN: 0036-8075
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    Neuromuscular disease. DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-09-23
    Description: The neuromuscular junction (NMJ) is the synapse between a motor neuron and skeletal muscle. Defects in NMJ transmission cause muscle weakness, termed myasthenia. The muscle protein Dok-7 is essential for activation of the receptor kinase MuSK, which governs NMJ formation, and DOK7 mutations underlie familial limb-girdle myasthenia (DOK7 myasthenia), a neuromuscular disease characterized by small NMJs. Here, we show in a mouse model of DOK7 myasthenia that therapeutic administration of an adeno-associated virus (AAV) vector encoding the human DOK7 gene resulted in an enlargement of NMJs and substantial increases in muscle strength and life span. When applied to model mice of another neuromuscular disorder, autosomal dominant Emery-Dreifuss muscular dystrophy, DOK7 gene therapy likewise resulted in enlargement of NMJs as well as positive effects on motor activity and life span. These results suggest that therapies aimed at enlarging the NMJ may be useful for a range of neuromuscular disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arimura, Sumimasa -- Okada, Takashi -- Tezuka, Tohru -- Chiyo, Tomoko -- Kasahara, Yuko -- Yoshimura, Toshiro -- Motomura, Masakatsu -- Yoshida, Nobuaki -- Beeson, David -- Takeda, Shin'ichi -- Yamanashi, Yuji -- G0701521/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Sep 19;345(6203):1505-8. doi: 10.1126/science.1250744.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. ; Department of Occupational Therapy, Nagasaki University School of Health Sciences, Nagasaki, Japan. ; Department of Electrical and Electronics Engineering, Faculty of Engineering, Nagasaki Institute of Applied Science, Nagasaki, Japan. ; Laboratory of Developmental Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ; Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. ; Division of Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. yyamanas@ims.u-tokyo.ac.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25237101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dependovirus ; Disease Models, Animal ; Female ; Genetic Therapy/*methods ; Genetic Vectors/administration & dosage ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle Proteins/*genetics ; Muscle, Skeletal/*innervation/physiopathology ; Muscular Dystrophies, Limb-Girdle/genetics/*pathology/*therapy ; Neuromuscular Junction/*pathology
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    Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-05-31
    Description: Synaptic vesicle recycling has long served as a model for the general mechanisms of cellular trafficking. We used an integrative approach, combining quantitative immunoblotting and mass spectrometry to determine protein numbers; electron microscopy to measure organelle numbers, sizes, and positions; and super-resolution fluorescence microscopy to localize the proteins. Using these data, we generated a three-dimensional model of an "average" synapse, displaying 300,000 proteins in atomic detail. The copy numbers of proteins involved in the same step of synaptic vesicle recycling correlated closely. In contrast, copy numbers varied over more than three orders of magnitude between steps, from about 150 copies for the endosomal fusion proteins to more than 20,000 for the exocytotic ones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilhelm, Benjamin G -- Mandad, Sunit -- Truckenbrodt, Sven -- Krohnert, Katharina -- Schafer, Christina -- Rammner, Burkhard -- Koo, Seong Joo -- Classen, Gala A -- Krauss, Michael -- Haucke, Volker -- Urlaub, Henning -- Rizzoli, Silvio O -- New York, N.Y. -- Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuro- and Sensory Physiology, University of Gottingen Medical Center, European Neuroscience Institute, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Gottingen, Germany. International Max Planck Research School Neurosciences, 37077 Gottingen, Germany. ; Bioanalytical Mass Spectrometry Group, Max-Planck-Institute for Biophysical Chemistry, 37077 Gottingen, Germany. ; Department of Neuro- and Sensory Physiology, University of Gottingen Medical Center, European Neuroscience Institute, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Gottingen, Germany. International Max Planck Research School Molecular Biology, 37077 Gottingen, Germany. ; Department of Neuro- and Sensory Physiology, University of Gottingen Medical Center, European Neuroscience Institute, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Gottingen, Germany. ; Leibniz Institut fur Molekulare Pharmakologie, Department of Molecular Pharmacology and Cell Biology, Robert-Rossle-Strasse 10, 13125 Berlin, Germany. ; Bioanalytical Mass Spectrometry Group, Max-Planck-Institute for Biophysical Chemistry, 37077 Gottingen, Germany. Bioanalytics, Department of Clinical Chemistry, University Medical Center Gottingen, 37075 Gottingen, Germany. ; Department of Neuro- and Sensory Physiology, University of Gottingen Medical Center, European Neuroscience Institute, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Gottingen, Germany. srizzol@gwdg.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876496" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism/ultrastructure ; Exocytosis ; Imaging, Three-Dimensional ; Immunoblotting/methods ; Mass Spectrometry/methods ; Microscopy, Electron/methods ; Models, Neurological ; Presynaptic Terminals/chemistry/*metabolism/ultrastructure ; Protein Transport ; Rats ; Rats, Wistar ; Synaptic Vesicles/chemistry/*metabolism ; Synaptosomes/chemistry/*metabolism/ultrastructure ; Vesicular Transport Proteins/analysis/*metabolism
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    Conversion of channelrhodopsin into a light-gated chloride channel (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-03-29
    Description: The field of optogenetics uses channelrhodopsins (ChRs) for light-induced neuronal activation. However, optimized tools for cellular inhibition at moderate light levels are lacking. We found that replacement of E90 in the central gate of ChR with positively charged residues produces chloride-conducting ChRs (ChloCs) with only negligible cation conductance. Molecular dynamics modeling unveiled that a high-affinity Cl(-)-binding site had been generated near the gate. Stabilizing the open state dramatically increased the operational light sensitivity of expressing cells (slow ChloC). In CA1 pyramidal cells, ChloCs completely inhibited action potentials triggered by depolarizing current injections or synaptic stimulation. Thus, by inverting the charge of the selectivity filter, we have created a class of directly light-gated anion channels that can be used to block neuronal output in a fully reversible fashion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wietek, Jonas -- Wiegert, J Simon -- Adeishvili, Nona -- Schneider, Franziska -- Watanabe, Hiroshi -- Tsunoda, Satoshi P -- Vogt, Arend -- Elstner, Marcus -- Oertner, Thomas G -- Hegemann, Peter -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):409-12. doi: 10.1126/science.1249375. Epub 2014 Mar 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biology, Experimental Biophysics, Humboldt Universitat zu Berlin, D-10115 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24674867" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Binding Sites ; CA1 Region, Hippocampal/cytology ; Chloride Channels/*chemistry/*metabolism ; Chlorides/*metabolism ; HEK293 Cells ; Humans ; Hydrogen Bonding ; Ion Channel Gating ; Light ; Models, Molecular ; Molecular Dynamics Simulation ; Mutation ; Patch-Clamp Techniques ; Protein Conformation ; Protein Engineering ; Pyramidal Cells/metabolism ; Rats ; Recombinant Fusion Proteins/chemistry ; Rhodopsin/*chemistry/genetics/*metabolism ; Transfection
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    Misleading results: don't blame the mice (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-01-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Churchill, Gary A -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):370. doi: 10.1126/science.343.6169.370-a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Jackson Laboratory, Bar Harbor, ME 04609, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458625" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation/*standards/*statistics & numerical data ; Animals ; Humans
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A single gene affects both ecological divergence and mate choice in Drosophila (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-02-15
    Description: Evolutionary changes in traits involved in both ecological divergence and mate choice may produce reproductive isolation and speciation. However, there are few examples of such dual traits, and the genetic and molecular bases of their evolution have not been identified. We show that methyl-branched cuticular hydrocarbons (mbCHCs) are a dual trait that affects both desiccation resistance and mate choice in Drosophila serrata. We identify a fatty acid synthase mFAS (CG3524) responsible for mbCHC production in Drosophila and find that expression of mFAS is undetectable in oenocytes (cells that produce CHCs) of a closely related, desiccation-sensitive species, D. birchii, due in part to multiple changes in cis-regulatory sequences of mFAS. We suggest that ecologically influenced changes in the production of mbCHCs have contributed to reproductive isolation between the two species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chung, Henry -- Loehlin, David W -- Dufour, Heloise D -- Vaccarro, Kathy -- Millar, Jocelyn G -- Carroll, Sean B -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Mar 7;343(6175):1148-51. doi: 10.1126/science.1249998. Epub 2014 Feb 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24526311" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Desiccation ; Drosophila/*genetics/physiology ; Ecosystem ; Evolution, Molecular ; Fatty Acid Synthases/*genetics/physiology ; *Genes, Insect ; *Genetic Variation ; Hydrocarbons/*metabolism ; *Mating Preference, Animal ; Molecular Sequence Data ; *Reproductive Isolation
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The big picture for big data: visualization (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-02-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shneiderman, Ben -- New York, N.Y. -- Science. 2014 Feb 14;343(6172):730. doi: 10.1126/science.343.6172.730-a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computer Science, University of Maryland, College Park, MD 20742, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24531954" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; *Computer Graphics ; *Database Management Systems ; Humans ; Information Dissemination/*methods ; Retinol-Binding Proteins, Cellular ; Vitamin A
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    Monolignol ferulate transferase introduces chemically labile linkages into the lignin backbone (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-04-05
    Description: Redesigning lignin, the aromatic polymer fortifying plant cell walls, to be more amenable to chemical depolymerization can lower the energy required for industrial processing. We have engineered poplar trees to introduce ester linkages into the lignin polymer backbone by augmenting the monomer pool with monolignol ferulate conjugates. Herein, we describe the isolation of a transferase gene capable of forming these conjugates and its xylem-specific introduction into poplar. Enzyme kinetics, in planta expression, lignin structural analysis, and improved cell wall digestibility after mild alkaline pretreatment demonstrate that these trees produce the monolignol ferulate conjugates, export them to the wall, and use them during lignification. Tailoring plants to use such conjugates during cell wall biosynthesis is a promising way to produce plants that are designed for deconstruction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilkerson, C G -- Mansfield, S D -- Lu, F -- Withers, S -- Park, J-Y -- Karlen, S D -- Gonzales-Vigil, E -- Padmakshan, D -- Unda, F -- Rencoret, J -- Ralph, J -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):90-3. doi: 10.1126/science.1250161.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700858" target="_blank"〉PubMed〈/a〉
    Keywords: Acyltransferases/*chemistry/*genetics/isolation & purification ; Angelica sinensis/enzymology/genetics ; Cell Wall/chemistry/metabolism ; Coumaric Acids/metabolism ; Genes, Plant ; Lignin/*chemistry/*metabolism ; Molecular Structure ; Plant Roots/enzymology ; Plants, Genetically Modified/genetics/growth & development ; Populus/*genetics/growth & development/*metabolism ; Trees/genetics/metabolism
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    Transcription. Comment on "Mechanism of eukaryotic RNA polymerase III transcription termination" (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-08-02
    Description: Nielsen et al. (Reports, 28 June 2013, p. 1577) characterized their RNA polymerase III (Pol III) preparation and concluded that it requires an RNA hairpin/duplex structure for terminating transcription. We could not corroborate their findings using bona fide Pol III from two laboratory sources. We show that Pol III efficiently terminates transcription in the absence of a hairpin/duplex in vitro and in vivo.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157655/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157655/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arimbasseri, Aneeshkumar G -- Kassavetis, George A -- Maraia, Richard J -- Z99 HD999999/Intramural NIH HHS/ -- ZIA HD000412-25/Intramural NIH HHS/ -- ZIA HD000412-26/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 Aug 1;345(6196):524. doi: 10.1126/science.1253783. Epub 2014 Jul 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. ; Division of Biological Sciences, University of California, San Diego, CA, USA. ; Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Commissioned Corps, U.S. Public Health Service. maraiar@mail.nih.gov.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25082694" target="_blank"〉PubMed〈/a〉
    Keywords: RNA Polymerase III/*metabolism ; Saccharomyces cerevisiae/*enzymology ; *Transcription Termination, Genetic
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    The ancient heritage of water ice in the solar system (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-09-27
    Description: Identifying the source of Earth's water is central to understanding the origins of life-fostering environments and to assessing the prevalence of such environments in space. Water throughout the solar system exhibits deuterium-to-hydrogen enrichments, a fossil relic of low-temperature, ion-derived chemistry within either (i) the parent molecular cloud or (ii) the solar nebula protoplanetary disk. Using a comprehensive treatment of disk ionization, we find that ion-driven deuterium pathways are inefficient, which curtails the disk's deuterated water formation and its viability as the sole source for the solar system's water. This finding implies that, if the solar system's formation was typical, abundant interstellar ices are available to all nascent planetary systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cleeves, L Ilsedore -- Bergin, Edwin A -- Alexander, Conel M O'D -- Du, Fujun -- Graninger, Dawn -- Oberg, Karin I -- Harries, Tim J -- New York, N.Y. -- Science. 2014 Sep 26;345(6204):1590-3. doi: 10.1126/science.1258055.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, University of Michigan, 311 West Hall, 1085 South University Avenue, Ann Arbor, MI 48109, USA. cleeves@umich.edu. ; Department of Astronomy, University of Michigan, 311 West Hall, 1085 South University Avenue, Ann Arbor, MI 48109, USA. ; Department of Terrestrial Magnetism, Carnegie Institution of Washington, Washington, DC 20015, USA. ; Harvard-Smithsonian Center for Astrophysics, Harvard University, Cambridge, MA 02138, USA. ; Department of Physics and Astronomy, University of Exeter, Stocker Road, Exeter EX4 4QL, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25258075" target="_blank"〉PubMed〈/a〉
    Keywords: Deuterium/chemistry ; Earth (Planet) ; *Ice ; Origin of Life ; *Solar System
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    Organic electronics. Room-temperature coupling between electrical current and nuclear spins in OLEDs (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-09-23
    Description: The effects of external magnetic fields on the electrical conductivity of organic semiconductors have been attributed to hyperfine coupling of the spins of the charge carriers and hydrogen nuclei. We studied this coupling directly by implementation of pulsed electrically detected nuclear magnetic resonance spectroscopy in organic light-emitting diodes (OLEDs). The data revealed a fingerprint of the isotope (protium or deuterium) involved in the coherent spin precession observed in spin-echo envelope modulation. Furthermore, resonant control of the electric current by nuclear spin orientation was achieved with radiofrequency pulses in a double-resonance scheme, implying current control on energy scales one-millionth the magnitude of the thermal energy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malissa, H -- Kavand, M -- Waters, D P -- van Schooten, K J -- Burn, P L -- Vardeny, Z V -- Saam, B -- Lupton, J M -- Boehme, C -- New York, N.Y. -- Science. 2014 Sep 19;345(6203):1487-90. doi: 10.1126/science.1255624. Epub 2014 Sep 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, USA. hmalissa@physics.utah.edu john.lupton@ur.de boehme@physics.utah.edu. ; Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, USA. ; Centre for Organic Photonics & Electronics, School of Chemistry and Molecular Biosciences, The University of Queensland, Queensland 4072, Australia. ; Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, USA. Institut fur Experimentelle und Angewandte Physik, Universitat Regensburg, 93053 Regensburg, Germany. hmalissa@physics.utah.edu john.lupton@ur.de boehme@physics.utah.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25237097" target="_blank"〉PubMed〈/a〉
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    Ancient DNA. Three-part ancestry for Europeans (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2014 Sep 5;345(6201):1106-7. doi: 10.1126/science.345.6201.1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25190770" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/*genetics ; European Continental Ancestry Group/*genetics ; Genome, Human ; Humans
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    Quaternary coral reef refugia preserved fish diversity (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-05-31
    Description: The most prominent pattern in global marine biogeography is the biodiversity peak in the Indo-Australian Archipelago. Yet the processes that underpin this pattern are still actively debated. By reconstructing global marine paleoenvironments over the past 3 million years on the basis of sediment cores, we assessed the extent to which Quaternary climate fluctuations can explain global variation in current reef fish richness. Comparing global historical coral reef habitat availability with the present-day distribution of 6316 reef fish species, we find that distance from stable coral reef habitats during historical periods of habitat loss explains 62% of the variation in fish richness, outweighing present-day environmental factors. Our results highlight the importance of habitat persistence during periods of climate change for preserving marine biodiversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pellissier, Loic -- Leprieur, Fabien -- Parravicini, Valeriano -- Cowman, Peter F -- Kulbicki, Michel -- Litsios, Glenn -- Olsen, Steffen M -- Wisz, Mary S -- Bellwood, David R -- Mouillot, David -- New York, N.Y. -- Science. 2014 May 30;344(6187):1016-9. doi: 10.1126/science.1249853.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Fribourg, Department of Biology, Chemin du Musee 10, CH-1700 Fribourg, Switzerland. Department of Bioscience, Aarhus University, 8000 C Aarhus, Denmark. ; Laboratoire Ecologie des Systemes Marins Cotiers UMR 5119, CNRS, Institut de Recherche pour le Developpement (IRD), Institut Francais de Recherche pour l'Exploitation de la Mer, UM2, UM1, cc 093, Place E. Bataillon, FR-34095 Montpellier Cedex 5, France. ; IRD, UR 227 CoReUs, LABEX (Laboratoire d'Excellence) Corail, Laboratoire Arago, Boite Postale 44, FR-66651 Banyuls/mer, France. CESAB (Centre de Synthese et d'Analyse sur la Biodiversite)-FRB (Fondation pour la Recherche sur la Biodiversite), Immeuble Henri Poincare, Domaine du Petit Arbois, FR-13857 Aix-en-Provence cedex 3, France. ; Centre for Macroevolution and Macroecology, Research School of Biology, Australian National University, Canberra, ACT 0200, Australia. ; IRD, UR 227 CoReUs, LABEX (Laboratoire d'Excellence) Corail, Laboratoire Arago, Boite Postale 44, FR-66651 Banyuls/mer, France. ; Department of Ecology and Evolution, Biophore Building, University of Lausanne, 1015 Lausanne, Switzerland. Swiss Institute of Bioinformatics, Quartier Sorge, 1015 Lausanne, Switzerland. ; Center for Ocean and Ice, Danish Meteorological Institute, Lyngbyvej 100, 2100 Copenhagen, Denmark. ; Department of Bioscience, Aarhus University, 8000 C Aarhus, Denmark. Department of Ecology and Environment, DHI Water and Environment, 2970 Horsholm, Denmark. ; Australian Research Council Centre of Excellence for Coral Reef Studies, and School of Marine and Tropical Biology, James Cook University, Townsville, QLD 4811, Australia. ; Laboratoire Ecologie des Systemes Marins Cotiers UMR 5119, CNRS, Institut de Recherche pour le Developpement (IRD), Institut Francais de Recherche pour l'Exploitation de la Mer, UM2, UM1, cc 093, Place E. Bataillon, FR-34095 Montpellier Cedex 5, France. Australian Research Council Centre of Excellence for Coral Reef Studies, and School of Marine and Tropical Biology, James Cook University, Townsville, QLD 4811, Australia. david.mouillot@univ-montp2.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876495" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Australia ; *Biodiversity ; *Climate Change ; *Conservation of Natural Resources ; *Coral Reefs ; *Fishes
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    Breast cancer. The advocate (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Mar 28;343(6178):1460-1. doi: 10.1126/science.343.6178.1460.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24675951" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; *Breast Neoplasms ; Female ; Humans ; *Patient Advocacy ; United States
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    Thermohaline circulation crisis and impacts during the mid-Pleistocene transition (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-06-28
    Description: The mid-Pleistocene transition (MPT) marked a fundamental change in glacial-interglacial periodicity, when it increased from ~41-thousand-year to 100-thousand-year cycles and developed higher-amplitude climate variability without substantial changes in the Milankovitch forcing. Here, we document, by using Nd isotopes, a major disruption of the ocean thermohaline circulation (THC) system during the MPT between marine isotope stages (MISs) 25 and 21 at ~950 to 860 thousand years ago, which effectively marks the first 100-thousand-year cycle, including an exceptional weakening through a critical interglacial (MIS 23) at ~900 thousand years ago. Its recovery into the post-MPT 100-thousand-year world is characterized by continued weak glacial THC. The MPT ocean circulation crisis facilitated the coeval drawdown of atmospheric CO2 and high-latitude ice sheet growth, generating the conditions that stabilized 100-thousand-year cycles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pena, Leopoldo D -- Goldstein, Steven L -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):318-22. doi: 10.1126/science.1249770. Epub 2014 Jun 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lamont-Doherty Earth Observatory of Columbia University, 61 Route 9W, Palisades, NY 10964, USA. leopoldo@ldeo.columbia.edu. ; Lamont-Doherty Earth Observatory of Columbia University, 61 Route 9W, Palisades, NY 10964, USA. Department of Earth and Environmental Sciences, Columbia University, 61 Route 9W, Palisades, NY 10964, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24968939" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Atmosphere/chemistry ; Carbon Dioxide/analysis ; *Climate ; *Ice Cover ; Isotopes/analysis ; Neodymium/analysis ; *Seawater ; *Water Cycle
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    Botany. Patterning cues from the altruistic sibling (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bayer, Martin -- New York, N.Y. -- Science. 2014 Apr 11;344(6180):158-9. doi: 10.1126/science.1252985.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24723601" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*embryology ; Arabidopsis Proteins/*metabolism ; *Body Patterning ; Flowers/*embryology ; Seeds/*embryology
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    Materials science. Fibers do the twist (2014)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2014-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yuan, Jinkai -- Poulin, Philippe -- New York, N.Y. -- Science. 2014 Feb 21;343(6173):845-6. doi: 10.1126/science.1250471.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre de Recherche Paul Pascal, CNRS, Universite de Bordeaux, 115 Avenue Schweitzer, 33600 Pessac, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24558149" target="_blank"〉PubMed〈/a〉
    Keywords: *Cotton Fiber ; Humans ; *Nylons ; *Tensile Strength ; *Torsion, Mechanical
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    T cell memory. Skin-resident memory CD8(+) T cells trigger a state of tissue-wide pathogen alert (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-10-04
    Description: After an infection, pathogen-specific tissue-resident memory T cells (T(RM) cells) persist in nonlymphoid tissues to provide rapid control upon reinfection, and vaccination strategies that create T(RM) cell pools at sites of pathogen entry are therefore attractive. However, it is not well understood how T(RM) cells provide such pathogen protection. Here, we demonstrate that activated T(RM) cells in mouse skin profoundly alter the local tissue environment by inducing a number of broadly active antiviral and antibacterial genes. This "pathogen alert" allows skin T(RM) cells to protect against an antigenically unrelated virus. These data describe a mechanism by which tissue-resident memory CD8(+) T cells protect previously infected sites that is rapid, amplifies the activation of a small number of cells into an organ-wide response, and has the capacity to control escape variants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ariotti, Silvia -- Hogenbirk, Marc A -- Dijkgraaf, Feline E -- Visser, Lindy L -- Hoekstra, Mirjam E -- Song, Ji-Ying -- Jacobs, Heinz -- Haanen, John B -- Schumacher, Ton N -- New York, N.Y. -- Science. 2014 Oct 3;346(6205):101-5. doi: 10.1126/science.1254803. Epub 2014 Aug 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands. ; Division of Biological Stress Response, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands. ; Experimental Animal Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands. ; Division of Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands. t.schumacher@nki.nl.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25278612" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CD8-Positive T-Lymphocytes/*immunology ; Female ; Immunologic Memory/genetics/*immunology ; Male ; Mice ; Skin/*immunology/microbiology/virology ; Transcriptome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Neuroscience. The Michael Jackson fly (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-05
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143233/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143233/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mann, Richard S -- R01 NS070644/NS/NINDS NIH HHS/ -- R01NS070644/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):48-9. doi: 10.1126/science.1252431.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700848" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila/*physiology ; Female ; Male ; Neurons/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    The vulnerable: Talene Yacoubian (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):26. doi: 10.1126/science.344.6179.26.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700836" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/*economics ; Parkinson Disease ; Research Personnel/*economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Genetics. Racing for disaster? (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-06-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2014 Jun 13;344(6189):1213-4. doi: 10.1126/science.344.6189.1213.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24925995" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Horses/*genetics/*physiology ; *Inbreeding ; Male ; *Physical Conditioning, Animal ; *Running ; Selection, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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