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  • Artikel  (307)
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  • Neueste Artikel (Zeitschrifteninhaltsverzeichnisse / in press)  (307)
  • Rats  (281)
  • Cloning, Molecular
  • 1980-1984  (307)
  • 1984  (143)
  • 1981  (164)
  • Biologie  (307)
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  • Artikel  (307)
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  • 1980-1984  (307)
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  • 1
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    Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into denervated hypothalamus (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-21
    Beschreibung: Fetal raphe cells transplanted into the hypothalamus reversed facilitation of feminine sexual behavior in rats with brain lesions induced by 5,7-dihydroxytryptamine. Immunocytochemical and chemical analyses of serotonin indicate that reinnervation of the ventromedial nucleus of the hypothalamus by the transplants is associated with behavioral recovery. The findings suggest that transplanted fetal tissue can exert functional regulation over an innate, complex, hormone-dependent behavior in adult rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luine, V N -- Renner, K J -- Frankfurt, M -- Azmitia, E C -- HD06368/HD/NICHD NIH HHS/ -- HD12011/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1436-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6209800" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 5,7-Dihydroxytryptamine/pharmacology ; Animals ; Castration ; Catecholamines/analysis ; Denervation ; Estradiol/pharmacology ; Female ; Fetus ; Hydroxyindoleacetic Acid/analysis ; Hypothalamus/*physiology/surgery ; Raphe Nuclei/*physiology/transplantation ; Rats ; Serotonin/*metabolism ; *Sexual Behavior, Animal ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    High-resolution proton nuclear magnetic resonance analysis of metastatic cancer cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-21
    Beschreibung: High-resolution proton nuclear magnetic resonance (NMR) studies of intact cancer cells revealed differences between cells with the capacity to metastasize and those that produce locally invasive tumors. The NMR resonances that characterize the metastatic cells were associated with an increased ratio of cholesterol to phospholipid and an increased amount of plasma membrane-bound cholesterol ester. High-resolution NMR spectroscopy could therefore be used to assess the metastatic potential of primary tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mountford, C E -- Wright, L C -- Holmes, K T -- Mackinnon, W B -- Gregory, P -- Fox, R M -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1415-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505699" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Membrane/analysis ; Cholesterol Esters/analysis ; *Magnetic Resonance Spectroscopy ; Membrane Lipids/analysis ; Neoplasm Metastasis/*etiology ; Neoplasms, Experimental/*analysis/pathology ; Rats ; Rats, Inbred Strains ; Triglycerides/analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Essential role of insulin in transcription of the rat 25,000 molecular weight casein gene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-14
    Beschreibung: Insulin is essential for the accumulation of rat casein messenger RNA (mRNA) in the presence of glucocorticoid and prolactin. The accumulation of certain mRNA's in other tissues has also been linked to insulin action. The present study shows that the accumulation effect on the 25,000 molecular weight rat casein mRNA does not reflect stabilization of the transcript by insulin. Rather, insulin is essential for its synthesis in the presence of glucocorticoid and prolactin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chomczynski, P -- Qasba, P -- Topper, Y J -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1326-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6390680" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Caseins/biosynthesis/*genetics ; Culture Techniques ; *Gene Expression Regulation ; Half-Life ; Hydrocortisone/physiology ; Insulin/*physiology ; Mammary Glands, Animal/metabolism ; Molecular Weight ; Prolactin/physiology ; RNA, Messenger/physiology ; Rats ; Transcription, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    RNA required for import of precursor proteins into mitochondria (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-14
    Beschreibung: A cytoplasmic RNA moiety is necessary for posttranslational uptake of nuclear-encoded mammalian proteins destined for the mitochondrial matrix. Post-translational addition of ribonuclease to a reticulocyte lysate-programmed cell-free translation mixture inhibited subsequent import of six different mitochondrial matrix enzyme precursors into rat liver mitochondria. The required RNA is highly protected, as indicated by the high concentrations of ribonuclease necessary to produce this inhibition. The dependence of the inhibitory effect on temperature, duration of exposure to ribonuclease, and availability of divalent cations is characteristic of the nuclease susceptibility of ribonucleoproteins. The ribonuclease-sensitive component was found in a 400-kilodalton fraction which contains the mitochondrial protein precursors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Firgaira, F A -- Hendrick, J P -- Kalousek, F -- Kraus, J P -- Rosenberg, L E -- AM 09527/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1319-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6209799" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell-Free System ; Cytoplasm/metabolism ; Mitochondria, Liver/*metabolism ; Ornithine Carbamoyltransferase/metabolism ; Protein Precursors/*metabolism ; *Protein Processing, Post-Translational ; RNA/*metabolism ; Rats ; Ribonucleases/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Intrinsic mechanisms of pain inhibition: activation by stress (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-14
    Beschreibung: Portions of the brain stem seem normally to inhibit pain. In man and laboratory animals these brain areas and pathways from them to spinal sensory circuits can be activated by focal stimulation. Endogenous opioids appear to be implicated although separate nonopioid mechanisms are also evident. Stress seems to be a natural stimulus triggering pain suppression. Properties of electric footshock have been shown to determine the opioid or nonopioid basis of stress-induced analgesia. Two different opioid systems can be activated by different footshock paradigms. This dissection of stress analgesia has begun to integrate divergent findings concerning pain inhibition and also to account for some of the variance that has obscured the reliable measurement of the effects of stress on tumor growth and immune function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terman, G W -- Shavit, Y -- Lewis, J W -- Cannon, J T -- Liebeskind, J C -- MH 15795/MH/NIMH NIH HHS/ -- NS-07628/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1270-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505691" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptation, Physiological ; Adrenalectomy ; Anesthesia ; Animals ; Brain Stem/physiology ; Conditioning (Psychology) ; Electroshock ; Endorphins/physiology ; Histamine/physiology ; Humans ; Hypophysectomy ; Immunosuppression ; Naltrexone/pharmacology ; Neoplasms/physiopathology ; Nociceptors/physiology ; Pain/*physiopathology ; Pentobarbital/pharmacology ; Rats ; Stress, Physiological/*physiopathology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Characterization and molecular cloning of a human parvovirus genome (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-07
    Beschreibung: The genome of the small human virus serologically associated with erythrocyte aplasia and erythema infectiosum (fifth disease) is shown to be a linear, nonpermuted, single-stranded DNA molecule with self-priming hairpin termini, properties which are characteristic of the genomes of the family Parvoviridae. This human parvovirus chromosome was molecularly cloned into bacterial plasmid vectors and the cloned DNA was used to explore its relatedness to other mammalian parvovirus serotypes by DNA:DNA hybridization. It is not related to the human adeno-associated viruses but does show a distant evolutionary relationship to genomes of the helper-independent parvoviruses of rodents. This strongly suggests that it is an autonomous parvovirus, and as such is the first example of a member of this group of common animal pathogens to cause disease in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cotmore, S F -- Tattersall, P -- CA29303/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1161-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6095448" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; Cloning, Molecular ; DNA, Single-Stranded/analysis ; DNA, Viral/*analysis ; DNA-Directed DNA Polymerase ; Dependovirus/genetics ; Escherichia coli/enzymology ; Nucleic Acid Denaturation ; Nucleic Acid Hybridization ; Parvoviridae/*genetics ; Plasmids ; Templates, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Cloned mycoplasma ribosomal RNA genes for the detection of mycoplasma contamination in tissue cultures (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-07
    Beschreibung: A cloned fragment of the mycoplasma ribosomal RNA operon was used as a molecular probe for the detection of mycoplasmas in cell cultures. According to the conditions of hybridization, the probe can detect prokaryotes in general or mycoplasmas specifically.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gobel, U B -- Stanbridge, E J -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1211-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505688" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cloning, Molecular ; *Culture Techniques ; Genes, Bacterial ; HeLa Cells ; Humans ; Mycoplasma/*genetics/isolation & purification ; Nucleic Acid Hybridization ; RNA, Ribosomal/*genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Nucleotide sequences of the human and mouse atrial natriuretic factor genes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-07
    Beschreibung: Mouse and human atrial natriuretic factor (ANF) genes have been cloned and their nucleotide sequences determined. Each ANF gene consists of three coding blocks separated by two intervening sequences. The 5' flanking sequences and those encoding proANF are highly conserved between the two species, while the intervening sequences and 3' untranslated regions are not. The conserved sequences 5' of the gene may play an important role in the regulation of ANF gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, C E -- Bloch, K D -- Klein, K A -- Smith, J A -- Seidman, J G -- AI-18436/AI/NIAID NIH HHS/ -- HL-070208/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1206-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6542248" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Atrial Natriuretic Factor ; Base Sequence ; Cloning, Molecular ; Gene Expression Regulation ; Genes ; Heart Atria/metabolism ; Humans ; Mice ; Natriuretic Agents ; Protein Precursors/genetics ; Proteins/*genetics ; Receptors, Glucocorticoid/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-07
    Beschreibung: The human T-cell leukemia (lymphotropic) virus type III (HTLV-III) appears to be central to the causation of the acquired immune deficiency syndrome (AIDS). Two full-length integrated proviral DNA forms of HTLV-III have now been cloned and analyzed, and DNA sequences of the virus in cell lines and fresh tissues from patients with AIDS or AIDS-related complex (ARC) have been characterized. The results revealed that (i) HTLV-III is an exogenous human retrovirus, approximately 10 kilobases in length, that lacks nucleic acid sequences derived from normal human DNA; (ii) HTLV-III, unlike HTLV types I and II, shows substantial diversity in its genomic restriction enzyme cleavage pattern; (iii) HTLV-III persists in substantial amounts in cells as unintegrated linear DNA, an uncommon property that has been linked to the cytopathic effects of certain animal retroviruses; and (iv) HTLV-III viral DNA can be detected in low levels in fresh (primary) lymphoid tissue of a minority of patients with AIDS or ARC but appears not to be present in Kaposi's sarcoma tissue. These findings have important implications concerning the biological properties of HTLV-III and the pathophysiology of AIDS and Kaposi's sarcoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaw, G M -- Hahn, B H -- Arya, S K -- Groopman, J E -- Gallo, R C -- Wong-Staal, F -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1165-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6095449" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*microbiology ; Base Sequence ; Cell Line ; Child ; Cloning, Molecular ; Cytopathogenic Effect, Viral ; DNA Restriction Enzymes/metabolism ; DNA, Viral/*analysis ; Deltaretrovirus/*genetics ; Humans ; Male ; Nucleic Acid Hybridization
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Morphine analgesia potentiated but tolerance not affected by active immunization against cholecystokinin (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-07
    Beschreibung: Administration of cholecystokinin was recently found to attenuate opiate analgesia. In the present study, the role of endogenous cholecystokinin in opiate analgesia was examined. Endogenously released cholecystokinin was sequestered by antibodies to cholecystokinin developed in response to an active immunization procedure. Morphine analgesia was potentiated and prolonged in rats immunized against cholecystokinin. The rate of development of morphine tolerance, however, was not affected by the antibodies. Endogenous cholecystokinin appears to function as a short-term modulator of opiate action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faris, P L -- McLaughlin, C L -- Baile, C A -- Olney, J W -- Komisaruk, B R -- ES-07066/ES/NIEHS NIH HHS/ -- MH-38894/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505689" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies ; Cholecystokinin/immunology/*physiology ; *Drug Tolerance ; Immunization ; Male ; Morphine/*pharmacology ; Pain/*physiology ; Rats ; Rats, Inbred Strains ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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