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  • Articles  (226)
  • Latest Papers from Table of Contents or Articles in Press  (226)
  • Humans  (224)
  • Middle Aged  (22)
  • Analytical Chemistry and Spectroscopy
  • Cell & Developmental Biology
  • Chemistry
  • Reproducibility of Results
  • 2015-2019
  • 1975-1979  (226)
  • 1978  (226)
  • Medicine  (226)
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  • Articles  (226)
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  • 2015-2019
  • 1975-1979  (226)
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  • 101
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    Cohort mortality for prostatic cancer among United States nonwhites (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: In recent decades, age-adjusted mortality rates from prostatic cancer have risen precipitously among blacks, remaining unchanged among whites. It is now the most common cancer among United States black males. When nonwhite mortality rates were examined by age and birth cohort, it was found that peak rates occurred at every age in the cohort of 1896 to 1900, and declined thereafter. This presages an arrest and reversal of the time trend in summary mortality rates as more recent nonwhite cohorts reach the ages of maximum risk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ernster, V L -- Selvin, S -- Winkelstein, W Jr -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1165-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653361" target="_blank"〉PubMed〈/a〉
    Keywords: *African Continental Ancestry Group ; Age Factors ; Aged ; European Continental Ancestry Group ; Humans ; Male ; Middle Aged ; Prostatic Neoplasms/*mortality
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 102
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    Sustained release of alcohol: subcutaneous silastic implants in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: A sustained-release device for use in ethanol dependence studies in mice is described. The Silastic device, dubbed SERT (sustained ethanol release tube), holds 0.35 milliliter of 95 percent ethanol (by volume) and is implanted under the skin of the back where it releases ethanol for up to 12 hours, with no observable tissue damage. The device may be adaptable to the release of other volatile liquids or drugs, in other animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erickson, C K -- Koch, K I -- Mehta, C S -- McGinity, J W -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1457-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/564551" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholic Intoxication/etiology ; Alcoholism/*etiology ; Animals ; *Disease Models, Animal ; Drug Administration Schedule ; Drug Implants ; Drug Tolerance ; Ethanol/*administration & dosage ; Humans ; Mice ; Silicone Elastomers
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
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    Cognitive development and social policy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: The city of Warsaw was razed at the end of World War II and rebuilt under a socialist government whose policy was to allocate dwellings, schools, and health facilities without regard to social class. Of the 14,238 children born in 1963 and living in Warsaw, 96 percent were given the Raven's Progressive Matrices Test and an arithmetic and a vocabulary test in March to June of 1974. Information was collected on the families of the children, and on characteristics of schools and city districts. Parental occupation and education were used to form a family factor, and the district data were collapsed into two factors, one relating to social marginality, and the other to distance from city center. Analysis showed that the initial assumption of even distribution of family, school, and district attributes was reasonable. Mental performance was unrelated either to school or district factors; it was related to parental occupation and education in a strong and regular gradient. It is concluded that an egalitarian social policy executed over a generation failed to override the association of social and family factors with cognitive development that is characteristic of more traditional industrial societies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Firkowska, A N -- Ostrowska, A -- Sokolowska, M -- Stein, Z -- Susser, M -- Wald, I -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1357-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663616" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Cognition ; Educational Status ; Environment ; Humans ; Occupations ; Poland ; Socioeconomic Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 104
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    Myoadenylate deaminase deficiency: a new disease of muscle (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: Five cases of a new disease presented with muscular weakness or cramping after exercise; three of the cases also had an elevated serum creatine phosphokinase. Muscle biopsies were histologically normal but lacked adenylate deaminase by stain and solution assay, while the erythrocyte isozyme was normal. A clinical diagnostic test has been developed, and the human enzyme was separated by acrylamide-gel electrophoresis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishbein, W N -- Armbrustmacher, V W -- Griffin, J L -- New York, N.Y. -- Science. 1978 May 5;200(4341):545-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644316" target="_blank"〉PubMed〈/a〉
    Keywords: AMP Deaminase/blood/*deficiency ; Adenine Nucleotides/metabolism ; Adenosine Deaminase/blood ; Adolescent ; Adult ; Child ; Creatine Kinase/metabolism ; Female ; Humans ; Male ; Muscles/enzymology ; Muscular Diseases/*enzymology ; Nucleotide Deaminases/*deficiency
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 105
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    The red cell as a fluid droplet: tank tread-like motion of the human erythrocyte membrane in shear flow (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-24
    Description: When whole human blood is subjected to viscometric flow, individual red cells are seen to be elongated and oriented in the shear field. In addition, a tank tread-like motion of the membrane around the cell content occurs. In dilute suspensions of erythrocytes in viscous media, the same behavior is better observed and can also be measured quantitatively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischer, T M -- Stohr-Lissen, M -- Schmid-Schonbein, H -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):894-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715448" target="_blank"〉PubMed〈/a〉
    Keywords: *Blood Viscosity ; Erythrocyte Membrane/*physiology ; Erythrocytes/*physiology/ultrastructure ; Humans ; Rheology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 106
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    Cancer death risk in hospitalized mental patients (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, B H -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):966-968.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684429" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Female ; Hospitalization ; Humans ; Male ; Mental Disorders/*complications ; Middle Aged ; Neoplasms/*mortality ; Risk ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 107
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    Evaluation of medical practices (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: Evaluation of the efficacy of a medical intervention requires valid measurements of both its benefits and risks as compared to those of alternative forms of management. The requisite measurements are more difficult to make than this simple description suggests, and the accumulation of information is further inhibited by certain characteristics of our pattern of health care. These features include, for example, discontinuous care by a variety of unrelated providers, inadequate records, the autonomy of physicians as decision-makers, financial disincentives, ambiguities in what we mean by "experimental" and "accepted" forms of therapy, and failure to see continuing evaluation as a necessary component of the cost of providing good medical care. Although no single change will solve all the problems of evaluation, several offer promise of improving our ability to choose from among medical interventions those most likely to be useful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frazier, H S -- Hiatt, H H -- New York, N.Y. -- Science. 1978 May 26;200(4344):875-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417402" target="_blank"〉PubMed〈/a〉
    Keywords: Cost-Benefit Analysis ; Defensive Medicine ; Delivery of Health Care/organization & administration ; Diagnostic Errors ; Ethics, Medical ; Humans ; Malpractice ; Medical Records ; *Quality of Health Care/economics ; Quality of Life ; Risk ; Therapeutics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 108
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    Immunoreactive vasopressin and oxytocin: concentration in individual human hypothalamic nuclei (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: Individual hypothalamic nuclei were microdissected from brain tissue of ten human subjects who had died suddenly while in apparent good health. Appreciable amounts of vasopressin and oxytocin immunoreactivity were found by specific radioimmunoassay in six hypothalamic nuclei including supraoptic and paraventricular nuclei. Vasopressin and oxytocin are presumed to be synthesized in supraoptic and paraventricular nuclei for axonal transport to the posterior pituitary for storage and release. Vasopressin and oxytocin in other hypothalamic nuclei may be a part of this system of neurosecretion or may serve some other function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉George, J M -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):342-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/556308" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Brain Chemistry ; Female ; Humans ; Hypothalamus/*analysis ; Male ; Median Eminence/analysis ; Middle Aged ; Oxytocin/*analysis ; Paraventricular Hypothalamic Nucleus/analysis ; Radioimmunoassay ; Supraoptic Nucleus/analysis ; Vasopressins/*analysis
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 109
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    Genetically determined sex-reversal in 46,XY humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉German, J -- Simpson, J L -- Chaganti, R S -- Summitt, R L -- Reid, L B -- Merkatz, I R -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):53-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567843" target="_blank"〉PubMed〈/a〉
    Keywords: Disorders of Sex Development/embryology/*genetics ; Female ; Humans ; Karyotyping ; Male ; Ovary/embryology ; Pedigree ; Sex Chromosome Aberrations/embryology ; Testis/embryology ; Turner Syndrome/embryology/*genetics
    Print ISSN: 0036-8075
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  • 110
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    Aggregation effects on oxygen binding of sickle cell hemoglobin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: Deoxygenation of concentrated solutions (0.33 gram per milliliter) of sickle cell hemoglobin show (i) a "crisis point" where the oxygen binding curve is unusually steep (Hill coefficient of 5 to 6), and (ii) a simultaneous increase in light scattering. Nearly identical oxygen binding curves are obtained upon oxygenation and deoxygenation of these solutions. The influence of aggregation is to shift the curve toward higher pressures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gill, S J -- Skold, R -- Fall, L -- Shaeffer, T -- Spokane, P -- Wyman, J -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):362-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663663" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Diphosphoglyceric Acids/blood ; Hemoglobin, Sickle/*metabolism ; Humans ; Oxygen/*blood ; Oxyhemoglobins/*metabolism ; Solubility
    Print ISSN: 0036-8075
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  • 111
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    Age affect and replicative life-span of fibroblasts of diabetic, prediabetic, and normal donors: another look at the data (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gleason, R E -- Goldstein, S -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1217-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725599" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; *Aging ; Cell Division ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus/*physiopathology ; Humans ; Middle Aged ; Prediabetic State/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 112
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    Entry of insulin into human cultured lymphocytes: electron microscope autoradiographic analysis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: Electron microscope autoradiographs were prepared of IM-9 human cultured lymphocytes incubated with iodine-125-labeled insulin. With the use of [125I]insulin and Ilford L-4 emulsion, the technique had a resolution half-distance of approximately 0.085 micrometer. Autoradiographs revealed a time-dependent entry of insulin into the cell interior that was maximal after 30 minutes of incubation. At this time point nearly 40 percent of the [125I]insulin was in the interior of the cell at a distance 1 micrometer or greater from the plasma membrane. Grain distribution and volume density analyses revealed that the intracellular insulin was concentrated in the endoplasmic reticulum and nuclear membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldfine, I D -- Jones, A L -- Hradek, G T -- Wong, K Y -- Mooney, J S -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):760-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715440" target="_blank"〉PubMed〈/a〉
    Keywords: Autoradiography ; Biological Transport ; Cell Nucleus/metabolism ; Cells, Cultured ; Endoplasmic Reticulum/metabolism ; Humans ; Insulin/*metabolism ; Kinetics ; Lymphocytes/*metabolism
    Print ISSN: 0036-8075
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  • 113
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    Chronologic and physiologic age affect replicative life-span of fibroblasts from diabetic, prediabetic, and normal donors (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Cultured skin fibroblasts from subjects with clinically apparent diabetes mellitus and from subjects genetically predisposed to diabetes have a replicative lifespan that is inversely related to donor age. Fibroblasts from carefully defined normal subjects not predisposed to diabetes fail to show this correlation. The data support the idea that physiologic status of the tissue donor is a more precise determinant of fibroblast replicative lifespan than chronologic age.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldstein, S -- Moerman, E J -- Soeldner, J S -- Gleason, R E -- Barnett, D M -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):781-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622567" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; *Aging ; Cell Division ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus/pathology/*physiopathology ; Fibroblasts/*cytology/pathology ; Humans ; Middle Aged ; Prediabetic State/pathology/*physiopathology ; Regression Analysis ; Skin/cytology/pathology
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  • 114
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    Prolactin synthesis by human chorion-decidual tissue: a possible source of prolactin in the amniotic fluid (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: Explants of human chorion-decidual tissue obtained at delivery from normal, full-term pregnancies synthesize and secrete prolactin. This hormone is indistinguishable from pituitary prolactin by chromatographic, electrophoretic, immunologic, and receptor assay techniques. These results suggest that chorion-decidua may be the source of the large quantities of prolactin in amniotic fluid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Golander, A -- Hurley, T -- Barrett, J -- Hizi, A -- Handwerger, S -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694535" target="_blank"〉PubMed〈/a〉
    Keywords: Amnion/metabolism ; Amniotic Fluid/*metabolism ; Chorion/*metabolism ; Decidua/*metabolism ; Female ; Humans ; In Vitro Techniques ; Pregnancy ; Prolactin/*biosynthesis ; Trophoblasts/metabolism
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  • 115
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    Retrograde amnesia produced by several treatments: evidence for a common neurobiological mechanism (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: This experiment examined the effects on memory of various amnestic treatments in animals earlier treated with the alpha-adrenergic antagonist phenoxybenzamine (PBZ). Thirty minutes before being trained in a one-trial inhibitory (passive) avoidance task, animals received an injection of PBZ or saline. Immediately after training, each animal received one of the following amnestic treatments: stimulation of the frontal cortex or amygdala, pentylenetetrazol, diethyldithiocarbamate, or cycloheximide. In control animals, each treatment produced retrograde amnesia. However, PBZ-treated animals did not develop amnesia. These findings suggest that there may be a common neurobiological mechanism underlying the amnesias produced by many treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, P E -- Sternberg, D B -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208153" target="_blank"〉PubMed〈/a〉
    Keywords: Amnesia/*etiology ; Amnesia, Retrograde/*etiology/prevention & control ; Amygdala/physiopathology ; Animals ; Avoidance Learning/drug effects ; Cerebral Cortex/physiopathology ; Cycloheximide/antagonists & inhibitors ; Ditiocarb/antagonists & inhibitors ; Electric Stimulation ; Humans ; Memory/*drug effects ; Mice ; Phenoxybenzamine/*pharmacology ; Rats ; Seizures/complications
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 116
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    Macroeconomics of disease prevention in the United States (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gori, G B -- Richter, B J -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1124-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653358" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Costs and Cost Analysis ; Environment ; Female ; Government ; Humans ; Infant ; Life Expectancy ; Male ; Middle Aged ; Population Dynamics ; *Preventive Medicine ; Social Security ; Socioeconomic Factors ; United States
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  • 117
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    Pattern formation by cultured human epidermal cells: development of curved ridges resembling dermatoglyphs (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: In cultures made from disaggregated human epidermal cells, growth to a confluent cell layer is followed by the emergence of patterns resembling those of human dermatoglyphs. These patterns reflect intrinsic properties of kertinocytes. In vivo, only the epidermis of the volar surfaces forms patterns, but in culture, patterns are formed by epidermal cells from other sites as well. Patterns develop by a process of cell movement which first produces ridges and then curves the ridges into figures of increasing complexity, ultimately whorls.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, H -- Thomas, J -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1385-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663617" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Differentiation ; Cell Movement ; Cells, Cultured ; *Dermatoglyphics ; Embryonic Induction ; Epidermis/*cytology ; Fibroblasts/cytology ; Humans ; Time Factors
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  • 118
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    Melatonin content of the human pineal gland (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: Gas chromatography with electron capture detection was used to quantitate melatonin in single human pineal glands. The sensitivity of this melatonin assay is in the low picogram range. A 24-hour rhythm of pineal melatonin content was observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greiner, A C -- Chan, S C -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):83-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉North Lawn Unit, Riverview Hospital, Essondale, British Columbia, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569491" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aged, 80 and over ; Chromatography, Gas ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Male ; Melatonin/analogs & derivatives/*analysis ; Middle Aged ; Pineal Gland/*chemistry
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    Iconic storage: the role of rods (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: The hypothesis that rods mediate iconic storage was tested by presenting letters of one color against a field of another. The colors were chosen to be discriminable only by the cones, only by the rods, or both. Under dark adaptation, the rods had little if any effect on partial-report advantage; however, they were important in determining the phenomenal persistence of the stimulus. Under light adaptation, the rods played no apparent role in either type of persistence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adelson, E H -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):544-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663675" target="_blank"〉PubMed〈/a〉
    Keywords: Afterimage/*physiology ; Color Perception/physiology ; Dark Adaptation ; Form Perception/physiology ; Humans ; Memory, Short-Term/*physiology ; Photoreceptor Cells/*physiology ; Time Factors
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    Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgetic focal stimulation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: Enkephalin-like activity has been measured in the ventricular cerebrospinal fluid of patients with intractable pain. Electrical stimulation of periventricular brain sites resulted in significant decrease in persistent pain in these subjects. This analgesia, which was blocked by naloxone in 80% of the cases, was accompanied by a significant rise in ventricular enkephalin-like activity, as measured by two different methods. The results present evidence of in vivo release of enkephalin-like material in humans and suggest that stimulation analgesia may be partially due to this release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Akil, H -- Richardson, D E -- Hughes, J -- Barchas, J D -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):463-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663668" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*physiopathology ; Cerebral Aqueduct ; Electric Stimulation ; Endorphins/*cerebrospinal fluid ; Enkephalins/*cerebrospinal fluid ; Female ; Humans ; Male ; Pain/*cerebrospinal fluid/physiopathology ; Pain Management
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    Controlled clinical trials (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alling, D W -- Halperin, M -- Ware, J H -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1105.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715462" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Research Design ; Statistics as Topic
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    Phenylalanine depletion for the management of phenylketonuria: use of enzyme reactors with immobilized enzymes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Multitubular enzyme reactors with immobilized phenylalanine ammonia lyase were tested in vitro and in vivo for depletion of phenylalanine in circulating blood. Sustained reduction of phenylalanine was achieved in less than 30 minutes. A 50% decrease of phenylalanine was obtained with a 2-hour application of enzyme reactors and was maintained for more than 2 days. Similar enzyme reactors have therapeutic potential for temporary management of phenylketonuric patients when their circulating phenylalanine becomes exceedingly high because of infection, fever, or pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ambrus, C M -- Ambrus, J L -- Horvath, C -- Pedersen, H -- Sharma, S -- Kant, C -- Mirand, E -- Guthrie, R -- Paul, T -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):837-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567372" target="_blank"〉PubMed〈/a〉
    Keywords: Ammonia-Lyases/*therapeutic use ; Animals ; *Disease Models, Animal ; Dogs ; Enzymes, Immobilized/*therapeutic use ; Extracorporeal Circulation ; Humans ; Phenylalanine/blood ; Phenylalanine Ammonia-Lyase/*therapeutic use ; Phenylketonurias/*therapy
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    Autoradiographic image intensification: applications in medical radiography (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-10
    Description: The image of an 80 to 90 percent underexposed medical radiograph can be increased to readable density and contrast by autoradiographic image intensification. The technique consists of combining the image silver of the radiograph with a radioactive compound, thiourea labeled with sulfur-35, and then making an autoradiograph from the activated negative.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Askins, B S -- New York, N.Y. -- Science. 1978 Feb 10;199(4329):684-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/625659" target="_blank"〉PubMed〈/a〉
    Keywords: Autoradiography/*methods ; Contrast Media ; Humans ; Mammography/methods ; Radiation Dosage ; *Radiographic Image Enhancement ; Radiography/methods ; Technology, Radiologic
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    Copulatory vocalizations of chacma baboons (Papio ursinus), gibbons (Hylobates hoolock), and humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: The copulatory vocalizations of female baboons (Papio ursinus) are more complex than those of female gibbons (Hylobates hoolock) or human females. Adult males of all these species begin calling later than the female, but subordinate baboon males do not call. Copulatory vocalizations may serve to mutually stimulate the mating partners or to incite male competition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamilton, W J 3rd -- Arrowood, P C -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1405-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663622" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Female ; Hominidae/*physiology ; Humans ; Hylobates/*physiology ; Male ; Middle Aged ; Papio/*physiology ; Respiration ; Sexual Behavior/*physiology ; Sexual Behavior, Animal/*physiology ; Vocalization, Animal/*physiology
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    Anxiety change through electroencephalographic alpha feedback seen only in high anxiety subjects (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-07-07
    Description: Subjects who were either high or low in trait anxiety used alpha feedback to increase and to decrease their electroencephalographic alpha activity. The alpha changes were tightly linked to anxiety changes, but only in high anxiety subjects (for whom anxiety was reduced in proportion to alpha increases, and was increased in proportion to alpha suppression). Low trait-anxiety subjects were superior at both enhancement and suppression training, but their alpha changes were not related to anxiety changes. In both groups, anxiety changes were generally unrelated to either resting levels or changes in frontalis electromyograms and respiration rate. These results suggest that long-term alpha feedback training (at least 5 hours) may be useful in anxiety therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hardt, J V -- Kamiya, J -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):79-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663641" target="_blank"〉PubMed〈/a〉
    Keywords: *Alpha Rhythm ; Anxiety/*physiopathology/therapy ; Biofeedback, Psychology/*physiology ; Humans ; Mmpi
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    Lichen myxedematosus serum stimulates human skin fibroblast proliferation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: Serum from patients with lichen myxedematosus, when added to exponentially growing normal human skin fibroblasts, stimulates DNA synthesis and cell proliferation. The degree of response in vitro is correlated with the extent of the disease in vivo and is specific for fibroblasts. The results suggest that there is a systemic factor (or factors) which may play a role in the etiology of diseases affecting the connective tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harper, R A -- Rispler, J -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):545-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622555" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Cells, Cultured ; Female ; Fibroblasts/metabolism ; Humans ; Immunoglobulin G/analysis ; Male ; Middle Aged ; Skin Diseases/*blood/immunology/pathology ; Thymidine/metabolism
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    Mummy of the "Elder Lady" in the tomb of Amenhotep II: Egyptian museum catalog number 61070 (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-06-09
    Description: An unidentified female mummy found in a cache of great kings and queens in 1898 in the Valley of the Kings was examined from the viewpoint of Egyptology, x-ray cephalometry, biostatistics, and biochemistry. The result was the identification of Queen Tiye, of the Eighteenth Dynasty, wife of Amenhotep III and mother of Akhenaton.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harris, J E -- Wente, E F -- Cox, C F -- Nawaway, I E -- Kowalski, C J -- Storey, A T -- Russell, W R -- Ponitz, P V -- Walker, G F -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1149-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/349693" target="_blank"〉PubMed〈/a〉
    Keywords: Cephalometry ; Egypt ; Electron Probe Microanalysis ; Female ; Hair/analysis ; History, Ancient ; Humans ; Middle Aged ; *Mummies ; Skull/radiography
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    Child spacing and birth order: effect on intellectual ability in two-child families (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: The effect on intellectual ability of the spacing of the birth of siblings was studied in two series of young men from two-child families: (i) 535 pairs of brothers and (ii) 1511 unrelated firstborn and secondborn. Birth-order effect and level of ability were not influenced by length of interval between firstborn and secondborn.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Belmont, L -- Stein, Z -- Zybert, P -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):995-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/568823" target="_blank"〉PubMed〈/a〉
    Keywords: *Birth Order ; Family ; Female ; Humans ; *Intelligence ; Male ; Maternal Age ; Socioeconomic Factors ; Time Factors
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    Is binocular vision always monocular? (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-06-30
    Description: Visual sensitivity of one eye was determined under binocular stimulus conditions yielding apparent fusion, stereopsis, monocular dominance, and monocular suppression. Marked losses in sensitivity accompanied monocular suppression but were not evident during stable singel vision. The results are inconsistent with the hypothesis that supression alone mediates binocular single vision.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blake, R -- Camisa, J -- New York, N.Y. -- Science. 1978 Jun 30;200(4349):1497-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663633" target="_blank"〉PubMed〈/a〉
    Keywords: Functional Laterality ; Humans ; Vision, Ocular/*physiology ; Visual Perception/*physiology
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Shotgun collections of Charon 3A bacteriophages containing Eco RI fragments of human and mouse DNA were constructed with the use of in vitro packaging. Plaques were screened by hybridization, and globin-specific clones were isolated from both human (Charon 3AHs51.1) and mouse (Charon 3AMm30.5). The fragments cloned were detected in unfractionated genomic DNA by the Southern method of hybridization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blattner, F R -- Blechl, A E -- Denniston-Thompson, K -- Faber, H E -- Richards, J E -- Slightom, J L -- Tucker, P W -- Smithies, O -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1279-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725603" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coliphages/genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Fetal Hemoglobin/genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; Poly A ; Poly T
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    Children absorb tris-BP flame retardant from sleepwear: urine contains the mutagenic metabolite, 2,3-dibromopropanol (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: The flame retardant, tris(2,3-dibromopropyl)phosphate (tris-BP), which is a mutagen and causes cancer and sterility in animals is absorbed from fabric by people. 2,3-Dibromopropanol, a metboloite of tris-BP and a mutagen itself, has been found in the urine samples of ten children who were wearing or who had worn tris-BP-treated sleepwear. Eight of these children were wearing well-washed sleepwear and the possibility of absorption of tris-BP from well-washed sleepwear discussed. 2,3-Dibromopropanol was not found in the urines of one child and one adult who had never worn tris-BP-treated garments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blum, A -- Gold, M D -- Ames, B N -- Jones, F R -- Hett, E A -- Dougherty, R C -- Horning, E C -- Dzidic, I -- Carroll, D I -- Stillwell, R N -- Thenot, J P -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1020-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684422" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Propanol/urine ; Child ; Chromatography, Gas ; *Clothing ; Female ; Flame Retardants/*metabolism ; Humans ; Hydrocarbons, Brominated/metabolism ; Mass Spectrometry/methods ; Mutagens/*metabolism ; Organophosphates/*metabolism ; *Propanols ; *Skin Absorption
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    Immunity to antigens associated with primate C-type oncoviruses in pregnant women (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Cell-mediated and humoral immune responses against antigens associated with primate C-type oncoviruses were evaluated in humans by microcytotoxicity and radioimmunoprecipitation assays. Five of six women tested sequentially during pregnancy developed selective cell-mediated reactivity against baboon endogenous virus (BEV)--infected human fibroblasts. Responsiveness peaked during the second and third trimesters and corresponded temporally with elevated antibody levels to BEV antigens. Similar cell-mediated reactivity was not observed in nonpregnant individuals. Selective cell-mediated reactivity directed against cells infected with the simian sarcoma virus-simian sarcoma associated virus complex (SSV--SSAV) was observed in four of 20 healthy adults (three of 14 nonpregnant, one of six pregnant). These observations suggest that cell-mediated reactivity against primate C-type oncoviruses is occasionally detected in healthy nonpregnant adults, but that during pregnancy both cell-mediated and humoral reactivity against BEV may become selectively expressed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirsch, M S -- Kelly, A P -- Chapin, D S -- Fuller, T C -- Black, P H -- Kurth, R -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1337-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204010" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/*analysis ; *Antigens, Viral ; Female ; Humans ; *Immunity, Cellular ; Papio/microbiology ; *Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Retroviridae/*immunology ; Sarcoma Virus, Woolly Monkey/immunology
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    Platelet factor 4: an inhibitor of collagenase (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: Human platelet factor 4 (PF4) is known to bind to heparin and inhibit its anticoagulant effect. This factor also inhibits the enzyme collagenase derived from cultured human skin and collagenase extracted from human granulocytes. The addition of heparin to the PF4-collagenase assay system has no effect on the observed inhibition of collagenase. Thus PF4 inhibits collagenase, in addition to neutralizing heparin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hiti-Harper, J -- Wohl, H -- Harper, E -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):991-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203038" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Coagulation Factors/*physiology ; Collagen/metabolism ; Glycine/metabolism ; Granulocytes/enzymology/metabolism ; Heparin/pharmacology ; Humans ; Microbial Collagenase/*antagonists & inhibitors/blood/metabolism ; Organ Culture Techniques ; Platelet Factor 4/pharmacology/*physiology ; Skin/enzymology/metabolism
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    Ethology of sleep studied with time-lapse photography: postural immobility and sleep-cycle phase in humans (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-09-29
    Description: Human sleep is characterized by episodes of immobility punctuated by major postural shifts. The organization of this motor activity was shown with a combination of photographic and electroencephalographic recording to be periodic and related to the electroencephalographic sleep cycle. The amount of immobility as measured photographically was positively related to subjective estimates of the goodness of sleep.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hobson, J A -- Spagna, T -- Malenka, R -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1251-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694515" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Electroencephalography ; Environment ; Female ; Humans ; Male ; *Movement ; Photography ; Sleep Stages/*physiology
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    Senators hear case for psychotherapy (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-09-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):794-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/356263" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Insurance Benefits/legislation & jurisprudence ; Medicaid/*legislation & jurisprudence ; Medicare/*legislation & jurisprudence ; *Psychotherapy ; United States
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    Skin color and nutrient photolysis: an evolutionary hypothesis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: Human populations native to areas of intense sunlight tend to be heavily melanized. Previous explanations for this relationship have invoked only weak selective pressures. To test the hypothesis that dark pigmentation may protect against photolysis of crucial light-sensitive vitamins and metabolites by ultraviolet light, folate was used as a model. It was found that exposure of human plasma in vitro to simulated strong sunlight causes 30 to 50 percent loss of folate within 60 minutes. Furthermore, light-skinned patients exposed to ultraviolet light for dermatologic disorders have abnormally low serum folate concentrations, suggesting that photolysis may also occur in vivo. Deficiency of folate, which occurs in many marginally nourished populations, causes severe anemia, fetal wastage, frank infertility, and maternal mortality. Prevention of ultraviolet photolysis of folate and other light sensitive nutrients by dark skin may be sufficient explanation for the maintenance of this characteristic in human groups indigenous to regions of intense solar radiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Branda, R F -- Eaton, J W -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):625-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675247" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; Climate ; Folic Acid/blood/*radiation effects ; Humans ; In Vitro Techniques ; Melanins/physiology ; Photolysis ; Phototherapy ; Skin Diseases/therapy ; *Skin Pigmentation ; Sunlight ; *Ultraviolet Rays
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    Somatically evoked magnetic fields of the human brain (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: The human brain is found to produce a magnetic field near the scalp which varies in synchrony with periodic electrical stimulation applied to a finger. Use of a highly sensitive superconducting quantum interference device as a magnetic field detector reveals that the brain's field is sharply localized over the primary projection area of the sensory cortex contralateral to the digit being stimulated. The phase of the response at the stimulus frequency varies monotonically with the repetition rate and at intermediate frequencies yields a latency of approximately 70 milliseconds for cortical response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brenner, D -- Lipton, J -- Kaufman, L -- Williamson, S J -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):81-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, New York University, New York, NY 10003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569490" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*physiology ; Brain Mapping ; Electric Stimulation ; *Electromagnetic Fields ; Fingers ; Humans ; Male ; Reaction Time ; Thumb
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    Infant astigmatism measured by photorefraction (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: Photorefraction of a sample of 93 infants of ages 1 day to 12 months showed that 63 percent of the subjects had astigmatism of 0.75 diopter or greater, and 12 percent greater than 2 diopters. Seventy percent of these astigmatisms were in the horizontal-vertical meridians. By comparison, only 8 percent of a sample of 26 adults tested by the same method showed astigmatism (all 0.75 to 1 diopter). The high incidence of infant astigmatism has implications for critical periods in human visual development and for infant acuity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Howland, H C -- Atkinson, J -- Braddick, O -- French, J -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):331-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694540" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Astigmatism/*diagnosis/epidemiology ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases/*diagnosis ; Photography ; Refraction, Ocular/*methods
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  • 139
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    In vitro fertilization: is it safe and repeatable? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1978 Aug 25;201(4357):698-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566955" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; *Ectogenesis ; Embryo Implantation ; Female ; *Fertilization ; Genetic Diseases, Inborn ; Humans ; Methods ; *Risk Assessment ; Zygote/transplantation
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  • 140
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    Behavioral teratology: birth defects of the mind (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):732-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/568821" target="_blank"〉PubMed〈/a〉
    Keywords: Anesthesia, Obstetrical/adverse effects ; Behavior/*drug effects ; Female ; Gonadal Steroid Hormones/adverse effects ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases/chemically induced ; Male ; Mental Disorders/*chemically induced ; Narcotics ; Pregnancy ; Semen/metabolism ; Spermatozoa/drug effects ; Substance Withdrawal Syndrome/etiology ; *Teratogens/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 141
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    Immunization against infectious disease (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: Mortality and morbidity from infectious diseases in the United States have declined more than 90 percent since 1900. Factors believed to be responsible for this decline include changes in the natural history of disease, sanitation, quarantine measures, control of nonhuman vectors, antibacterial drugs, and immunization. The contributions of each of these factors differ among the various infectious diseases; except for smallpox and diphtheria control, immunization had little effect until after World War II. The success of present and future immunization programs is endangered by public and physician complacency and by complex legal and ethical problems related to informed consent and responsibility for rare, vaccine-related injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mortimer, E A Jr -- New York, N.Y. -- Science. 1978 May 26;200(4344):902-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347579" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; *Communicable Disease Control ; Communicable Diseases/history/mortality ; History, 20th Century ; Humans ; *Immunization/adverse effects/history ; Infant ; Middle Aged ; United States ; Vaccination/history ; Vaccines/adverse effects ; Vaccines, Attenuated/adverse effects
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  • 142
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    Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurland, J I -- Bockman, R S -- Broxmeyer, H E -- Moore, M A -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):552-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/304600" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells ; Cell Differentiation ; Cells, Cultured ; Colony-Stimulating Factors/*physiology ; Feedback ; Glycoproteins/*physiology ; Granulocytes/*cytology ; *Hematopoiesis ; Humans ; Leukocytes/*cytology ; Macrophages/cytology/*physiology ; Mice ; Models, Biological ; Monocytes/*physiology ; Prostaglandins E/*physiology
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  • 143
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    Cholecystokinin inhibits tail pinch-induced eating in rats (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: Peripheral administration of the COOH-terminal octapeptide of cholecystokinin in doses from 1 to 100 micrograms per kilogram of body weight (0.25 to 25.0 micrograms per rat) significantly antagonized tail pinch-induced eating in rats, an animal model for stress-induced human hyperphagia. Centrally administered cholecystokinin was effective only in high doses (3 micrograms into the cerebral ventricle). The finding that the minimal effective dose of cholecystokinin in suppressing stress-induced appetitive behavior is smaller after peripheral than central administration suggests that the peptide is acting on peripheral, as opposed to central nervous system, substrates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nemeroff, C B -- Osbahr, A J 3rd -- Bissette, G -- Jahnke, G -- Lipton, M A -- Prange, A J -- New York, N.Y. -- Science. 1978 May 19;200(4343):793-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/565535" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Bradykinin/pharmacology ; Cholecystokinin/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Feeding Behavior/*drug effects ; Humans ; Male ; Peptide Fragments/pharmacology ; Rats ; Stress, Psychological
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    Analysis of melatonin in human plasma by gas chromatography negative chemical ionization mass spectrometry (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-25
    Description: Three techniques have been used to measure human plasma melatonin: bioassay, radioimmunoassay, and gas chromatography--mass spectrometry (GC-MS). GC-MS is theoretically capable of the greatest specificity, but in general suffers from insufficient sensitivity. Negative chemical ionization, a new technique, provides a 150-fold increase in GC-MS sensitivity for electron-capturing compounds. Negative chemical ionization GC-MS permits routine measurement in human plasma of melatonin at a concentration as low as 1 picogram per milliliter.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewy, A J -- Markey, S P -- New York, N.Y. -- Science. 1978 Aug 25;201(4357):741-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675255" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anions ; Chromatography, Gas/methods ; Circadian Rhythm ; Female ; Humans ; Male ; Mass Spectrometry/methods ; Melatonin/*blood
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  • 145
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    Antibody-dependent lymphocytotoxicity induced by immunoglobulin G from Hodgkin's disease splenic lymphocytes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: Immunoglobulin G, produced in cultures of splenic lymphocytes obtained from patients with Hodgkin's disease, bound to a population of homologous peripheral blood lymphocytes and initiated antibody-dependent cell cytotoxicity in cultures from five out of eight patients. Two patients whose cultures produced negative results had minimal disease; the other was in remission. The target cells appear to be T lymphocytes; the effector cells bear Fc receptors that are inhibited by antigen-antibody complexes. Antibody-dependent cell cytotoxicity events may produce the anergy and lymphopenia often seen in Hodgkin's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Longmire, R L -- Ryan, S -- McMillan, R -- Lightsey, A -- Heath, V -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):71-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Hematology and Oncology, Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569485" target="_blank"〉PubMed〈/a〉
    Keywords: *Antibody-Dependent Cell Cytotoxicity ; Cells, Cultured ; Hodgkin Disease/*immunology ; Humans ; Immunoglobulin G/*immunology ; Lymphocytes/*immunology ; Spleen/cytology/immunology ; T-Lymphocytes/*immunology
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  • 146
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    Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Erythroid colonies, raised from erythroid stem cells circulating in the peripheral blood of normal adult individuals, synthesize considerable amounts of fetal hemoglobin. In cultures from persons with sickling disorders, amounts of hemoglobin F that are known to inhibit sickling in vivo are produced. The results provide evidence that primitive erythroid progenitors are able to express the hemoglobin F production program and that cultures of mononuclear cells of the adult blood can be used to investigate the mechanisms involved in regulation of gamma-globin gene switching.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Papayannopoulou, T -- Nakamoto, B -- Buckley, J -- Kurachi, S -- Nute, P E -- Stamatoyannopoulos, G -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1349-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628844" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anemia, Sickle Cell/blood ; Cell Differentiation ; Cells, Cultured ; Fetal Hemoglobin/*biosynthesis ; Hematopoietic Stem Cells/cytology/*metabolism ; Hemoglobin A/biosynthesis ; Hemoglobin, Sickle/biosynthesis ; Humans ; Reticulocytes/metabolism ; Thalassemia/blood
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  • 147
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    Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: Long-term treatment of rats with haloperidol produced an increased sensitivity to the locomotor and stereotypic effect of apomorphine. This behavioral dopaminergic supersensitivity was accompanied by increased binding of [3H] spiroperidol in the striatum. Rats treated concurrently with lithium and haloperidol failed to develop both behavioral sensitivity to apomorphine and increased striatal dopamine receptor binding. The ability of lighium to prevent recurrent manicdepressive episodes may be related, in part, to its ability to stabilize dopaminergic receptor sensitivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pert, A -- Rosenblatt, J E -- Sivit, C -- Pert, C B -- Bunney, W E Jr -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566468" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/pharmacology ; Corpus Striatum/metabolism ; Haloperidol/pharmacology ; Humans ; Lithium/*pharmacology ; Male ; Rats ; Receptors, Dopamine/*drug effects/metabolism ; Spiperone/metabolism ; Stereotyped Behavior/drug effects ; Time Factors
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  • 148
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    Nicotine in breast fluid of nonlactating women (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-20
    Description: Using a combination of gas chromatography, mass spectrometry, and selected ion recording techniques, we have identified nicotine and its major metabolite, continine, in the breast fluid of nonlactating women smokers. As little as 25 picograms could be measured by using the deuterated variants, [5',5'-2H]nicotine and [3,3-2H]cotinine, both as internal standards and as carriers in an inverse isotope dilution method.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petrakis, N L -- Gruenke, L D -- Beelen, T C -- Castagnoli, N Jr -- Craig, J C -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):303-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619458" target="_blank"〉PubMed〈/a〉
    Keywords: Body Fluids/analysis ; Breast/*analysis ; Cotinine/analysis ; Female ; Humans ; Nicotine/*analysis ; Smoking
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    "Resolution" of diploid-tetraploid tree frogs (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ralin, D B -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):335-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567845" target="_blank"〉PubMed〈/a〉
    Keywords: Albumins/genetics ; Animals ; Anura/*genetics ; Humans ; *Ploidies
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  • 150
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    Palmitoleic acid in erythrocytes from carriers of Duchenne muscular dystrophy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rao, G A -- Siler, K -- Larkin, E C -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1416.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663625" target="_blank"〉PubMed〈/a〉
    Keywords: Erythrocyte Membrane/*metabolism ; Erythrocytes/*metabolism ; Fatty Acids, Unsaturated/*blood ; Humans ; Membrane Lipids/blood ; Muscular Dystrophies/*blood ; Phospholipids/blood ; Plasmalogens/blood
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  • 151
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    Age determination of an Alaskan mummy: morphological and biochemical correlation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Aspartic acid racemization analysis of a tooth from an Alaskan mummy yielded an age at death of 53 (+/- 5) years, which correlates well with earlier estimates based on morphological features. This study illustrates the value of integrative approaches to paleopathologic problems and the importance of preserving rare specimens for the application of new techniques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Masters, P M -- Zimmerman, M R -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):811-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/356264" target="_blank"〉PubMed〈/a〉
    Keywords: *Aspartic Acid ; Bicuspid ; Female ; History, Ancient ; Humans ; Middle Aged ; Mummies ; *Paleodontology ; Stereoisomerism
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  • 152
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    Hair: a diagnostic tool to complement blood serum and urine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1271-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725602" target="_blank"〉PubMed〈/a〉
    Keywords: Celiac Disease/diagnosis ; Clinical Laboratory Techniques/*methods ; Diabetes Mellitus, Type 1/diagnosis ; Hair/*analysis ; Humans ; Intellectual Disability/diagnosis ; Research Design ; Trace Elements/*analysis ; Zinc/deficiency
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  • 153
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    Chemical carcinogens: how dangerous are low doses? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):37-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694517" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotransformation ; *Carcinogens/metabolism/standards ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Environmental Exposure ; Humans ; Inactivation, Metabolic ; Neoplasms/*chemically induced ; Oxidation-Reduction
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  • 154
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    Advances in medical instrumentation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ream, A K -- New York, N.Y. -- Science. 1978 May 26;200(4344):959-64.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644338" target="_blank"〉PubMed〈/a〉
    Keywords: Computers ; Costs and Cost Analysis ; Economics, Hospital ; Humans ; Medical Laboratory Science/economics/*instrumentation ; Monitoring, Physiologic/economics/instrumentation ; Quality of Health Care ; Tomography, X-Ray Computed/economics
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  • 155
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    A fertility reaction to a historical event: southern white birthrates and the 1954 desegregation ruling (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: On 17 May 1954 the Supreme Court, in its decision in Brown v. Board of Education, declared de jure segregation of the public schools to be unconstitutional. It is argued here that a consequence of that decision was a decline in childbearing among white Southerners. In the nation as a whole, period fertility rates increased between 1954 and 1955, but in 9 of the 11 former Confederate states they decreased. Further analysis shows that these Southern fertility decreases began about 12 months after the Supreme Court decision. This variation in behavior in reaction to a historical event has important implications for the explanation and prediction of fertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rindfuss, R R -- Reed, J S -- John, C -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351806" target="_blank"〉PubMed〈/a〉
    Keywords: *Birth Rate ; *European Continental Ancestry Group ; History, 20th Century ; Human Rights ; Humans ; Legislation as Topic ; Psychology, Social ; *Schools ; *Social Change ; United States
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  • 156
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    Morphological alterations in hippocampus after long-term alcohol consumption in mice (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-08-18
    Description: Golgi methods were used to examine the hippocampus of laboratory mice that received alcohol-containing or control diets for 4 months followed by a 2-month alcohol-free period. Long-term alcohol consumption resulted in a significant loss of dendritic spines on hippocampal pyramidal cells and dentate granule cells. This study provides evidence that long-term alcohol consumption, in the absence of malnutrition, produces morphological damage to the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, J N -- Walker, D W -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):646-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566953" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/*pathology ; Animals ; Dendrites/ultrastructure ; *Disease Models, Animal ; Female ; Hippocampus/*pathology ; Humans ; Mice ; Pyramidal Tracts/pathology
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    Sickling rates of human AS red cells infected in vitro with Plasmodium falciparum malaria (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-10
    Description: The kinetics of sickling of malaria-infected red cells from humans with sickle cell trait were studied in vitro in an attempt to obtain direct experimental evidence for a selective advantage of the hemoglobin S heterozygote in a malarious region. The sickling rates of cells infected with Plasmodium falciparum and of non-infected cells were studied both in the total absence of oxygen (by dithionite addition) and at several different concentrations of oxyhemoglobin which might obtain in vivo. In all cases, red cells containing small plasmodium parasite forms (ring forms) sickled approximately eight times as readily as uninfected cells. Cells containing large parasitic forms (trophozoites and schizonts) appeared to sickle less readily than uninfected cells, by light microscopy criteria, but electron micrographs demonstrated the presence of polymerized deoxyhemoglobin S with a high frequency. It is concluded that enhanced sickling of plasmodium-infected AS cells may be one mechanism whereby the hemoglobin S polymorphism is balanced in favor of the heterozygote.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, E F Jr -- Friedman, M -- Ueda, Y -- Tellez, I -- Trager, W -- Nagel, R L -- New York, N.Y. -- Science. 1978 Nov 10;202(4368):650-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/360396" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*parasitology ; Erythrocytes, Abnormal/*parasitology ; Heterozygote ; Humans ; Kinetics ; Malaria/*blood ; Plasmodium falciparum ; Sickle Cell Trait/parasitology
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  • 158
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    Emotions are expressed more intensely on the left side of the face (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-27
    Description: Pictures of human faces posing six distinct emotions (plus a neutral expression) and their mirror reversals were split down the midlines, and left-side and right-side composites were constructed. Subjects judged left-side composites as expressing emotions more intensely than right-side composites. The finding indicates hemispheric asymmetry in the control over emotional expression in the face.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sackeim, H A -- Gur, R C -- Saucy, M C -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):434-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705335" target="_blank"〉PubMed〈/a〉
    Keywords: *Emotions ; *Facial Expression ; Female ; *Functional Laterality ; Humans ; Male
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  • 159
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    Commissural transmission: maturational changes in humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: Latency differences between ipsilateral and contralateral somatosensory evoked potentials show maturational trends in keeing with the myelogenic timetable and development of the corpus callosum. The distribution and modality-specific projection of early ipsilateral activity suggests an origin in the contralateral posterior-parietal area.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salamy, A -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1409-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208144" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Child ; Child, Preschool ; Corpus Callosum/*growth & development/physiology ; Evoked Potentials ; Humans ; Somatosensory Cortex/physiology ; *Synaptic Transmission
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    H-Y antigen gene loci (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, F H -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):842.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567373" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Genes ; Humans ; Isoantigens/*genetics ; Male ; X Chromosome ; Y Chromosome
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  • 161
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    Astigmatism in infants (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-10-20
    Description: Compared with children of school age, infants show ten times the incidence and considerably greater amounts of clinically significant astigmatism. The amount begins to decrease in the second semester of life, and the incidence declines during the third year. The unanticipated results bear on both the etiology and the neural sequelae of astigmatism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mohindra, I -- Held, R -- Gwiazda, J -- Brill, J -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694539" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Astigmatism/*epidemiology/etiology/physiopathology ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases/epidemiology
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  • 162
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    Neural organization and evolution of thermal regulation in mammals (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-07-07
    Description: This article proposes a modification of the currently accepted view of the central neural integration of body temperature. In place of a single integrator with multiple inputs and outputs, the new model includes as many integrators as there are thermoregulatory responses. Futhermore, these integrators are postulated to be represented at many levels of the nervous system, with each level facilitated or inhibited by levels above and below. The purpose of such a complicated arrangement is to achieve finer and finer control over body temperature. A consideration of how endothermy might have evolved, with originally nonthermally related responses gradually coming under thermal control, makes such a brain organization highly reasonable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Satinoff, E -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):16-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351802" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Biological Evolution ; *Body Temperature Regulation ; Brain/*physiology ; Fever/physiopathology ; Humans ; Hypothalamus/*physiology ; Mammals/*physiology ; Models, Neurological ; *Nervous System Physiological Phenomena ; Pain/physiopathology ; Reflex/physiology ; Skin/innervation ; Spinal Cord/physiology ; Thermoreceptors/*physiology
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    The current emphasis on preventive medicine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saward, E -- Sorensen, A -- New York, N.Y. -- Science. 1978 May 26;200(4344):889-94.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644331" target="_blank"〉PubMed〈/a〉
    Keywords: Attitude to Health ; Education, Medical ; Environment ; Environmental Exposure ; Environmental Health ; Government ; Humans ; Insurance, Health ; Nutritional Physiological Phenomena ; *Preventive Medicine ; Public Health ; Risk ; United States
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  • 164
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    Compulsive, abnormal walking caused by anticholinergics in akinetic, 6-hydroxydopamine-treated rats (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-03-31
    Description: In otherwise profoundly akinetic rats that had been severely depleted of brain catecholamines, anticholinergic drugs caused excessive walking. The effect did not appear until 10 days after surgery and then increased with time, suggesting that a phenomenon analogous to denervation supersensitivity may be involved. If the animals walked into corners, they were unable to turn around or back out. Their gait (extremely short steps) was reminiscent of that of patients with Parkinson's disease. The results are consistent with a mutually antagonistic interaction between cholinergic and dopaminergic brain systems and emphasize certain complexities in this interaction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schallert, T -- Whishaw, I Q -- Ramirez, V D -- Teitelbaum, P -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1461-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/564552" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/*pharmacology/therapeutic use ; Catalepsy/chemically induced/drug therapy ; Gait ; Humans ; Hydroxydopamines/*pharmacology ; Locomotion/*drug effects ; Male ; Rats
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  • 165
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    Tricyclic antidepressants: therapeutic properties and affinity for alpha-noradrenergic receptor binding sites in the brain (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: Tricyclic antidepressants vary in their capacity to cause psychomotor activation, to relieve agitated depressive states, and to cause sedation and hypotension. We have quantified relative potencies of tricyclic antidepressants in competing for the binding of 3H-labeled WB-4101 to alpha-noradrenergic receptor sites in rat brain membranes. Affinities of tricyclic drugs for alpha-noradrenergic receptor sites in the brain correlate well with the capacity of these agents to relieve psychomotor agitation and to induce sedation and hypotension; these affinities also correlate inversely with tendencies to elicit psychomotor activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉U'Prichard, D C -- Greenberg, D A -- Sheehan, P P -- Snyder, S H -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):197-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/202024" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents, Tricyclic/*metabolism/therapeutic use ; Binding, Competitive ; Brain/*metabolism ; Humans ; Hypotension/chemically induced ; Psychomotor Agitation/*drug therapy ; Rats ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, alpha/*metabolism ; Structure-Activity Relationship
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    Intellectual status of working-class children adopted early into upper-middle-class families (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-30
    Description: Failure rates observed (13 +/- 6 percent for school failures, 17 +/- 5 percent for scores below 95 on a collective IQ test) were far below those expected from the social class of birth (55 percent, 51 percent) or observed in a control group (56 +/- 8 percent, 49 +/- 9 percent) but close to those expected from the social class of adoption (15 percent, 15 percent).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schiff, M -- Duyme, M -- Dumaret, A -- Stewart, J -- Tomkiewicz, S -- Feingold, J -- New York, N.Y. -- Science. 1978 Jun 30;200(4349):1503-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663634" target="_blank"〉PubMed〈/a〉
    Keywords: *Adoption ; Humans ; *Intelligence ; Intelligence Tests ; Socioeconomic Factors ; Wechsler Scales
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    1976 swine flu campaign faulted yet principals would do it again (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):849, 851-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715445" target="_blank"〉PubMed〈/a〉
    Keywords: Disease Outbreaks/*prevention & control ; Humans ; Immunization ; *Influenza Vaccines ; Influenza, Human/prevention & control ; Preventive Health Services
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  • 168
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    Adherence of group A streptococci to pharyngeal cells: a role in the pathogenesis of rheumatic fever (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: We used an assay in vitro to investigate the possible role of streptococcal adherence to human pharyngeal cells in the pathogenesis of acute rheumatic fever. There was no difference in adherence of rheumatic fever-associated and non-associated strains of group A streptococci to pooled pharyngeal cells of normal people. Likewise, streptococci not associated with rheumatic fever adhered equally well to cells taken from normal people and from patients with rheumatic heart disease. However, the pharyngeal cells of all nine rheumatic heart disease patients tested had increased avidity for adherence for a rheumatic fever-associated strain of streptococcus compared to the pharyngeal cells obtained from age- and sex-matched controls. Increased streptococcal adherence to pharyngeal cells of rheumatic fever-prone patients may play a role in the pathogenesis of rheumatic fever.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Selinger, D S -- Julie, N -- Reed, W P -- Williams, R C Jr -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):455-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351810" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Male ; Middle Aged ; Pharyngeal Diseases/complications/microbiology ; Pharynx/*microbiology ; Rheumatic Fever/*etiology/microbiology ; Streptococcus pyogenes/*physiology
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    Genetics and Medicine: an evolving relationship (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-05-26
    Description: The rapid expansion of knowledge in human and medical genetics has revealed at least 6 percent average heterozygosity per structural gene locus, in excess of 2300 Mendelian (single gene) variants and several hundred chromosomal variants in man. This means that with the exception of monozygous twins, no two individuals are alike in their phenotype. Therefore, each person has a relative state of health, and genetic factors contribute significantly to disease. The ubiquity of genetic diversity requires the development of services for genetic screening, diagnosis, and counseling to prevent and treat a major portion of disease in modern society. Specific programs in Quebec and Canada illustrate how individuals and populations can be served by such services. Better education of citizens and health professionals in human genetics is essential for the further improvement of genetics services in society.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scriver, C R -- Laberge, C -- Clow, C L -- Fraser, F C -- New York, N.Y. -- Science. 1978 May 26;200(4344):946-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644337" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Chemical Analysis ; Canada ; Genetic Counseling ; Genetic Diseases, Inborn/epidemiology/*genetics ; Genetics, Medical ; Humans ; Insurance, Health ; Mass Screening ; Prenatal Diagnosis ; Quebec
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    Pollution in Maryland valley (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Capurro, P U -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):731.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622563" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollution ; Humans ; *Industrial Waste ; Maryland ; Neoplasms/*chemically induced/epidemiology
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  • 171
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    Enzyme-linked immunosorbent assay for identification of rotaviruses from different animal species (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-21
    Description: Rotaviruses cause gastroenteritis in man and a wide variety of animal species. They cross-react in many immunologic tests and have a similar appearance by electron microscopy, making differentiation among them difficult. Rotaviruses derived from different host species were distinguished by postinfection serum blocking virus activity in an enzyme-linked immunosorbent assay (ELISA). Thirty-three rotavirus isolates from children living in three different parts of the world could not be differentiated by this technique, but they were distinct from four strains recovered from calves, and a series of strains isolated from piglets, foals, monkeys, and infant mice. The four bovine strains were similar, but they could be differentiated from the other animal strains, each of which exhibited a distinct pattern when tested by the ELISA blocking technique.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yolken, R H -- Barbour, B -- Wyatt, R G -- Kalica, A R -- Kapikian, A Z -- Chanock, R M -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):259-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208150" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/analysis ; Antibody Specificity ; Antigens, Viral/analysis ; Cattle/microbiology ; Diarrhea/*microbiology ; Enzyme-Linked Immunosorbent Assay ; Horses/microbiology ; Humans ; Mice/microbiology ; RNA Viruses/*classification ; Rotavirus/*classification/immunology ; Swine/microbiology
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  • 172
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    Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-21
    Description: The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wise, R A -- Spindler, J -- deWit, H -- Gerberg, G J -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):262-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Conditioning, Operant/drug effects ; Food ; Humans ; Parkinson Disease/physiopathology ; Pimozide/*pharmacology ; Rats ; Receptors, Dopamine/drug effects ; *Reward ; Schizophrenia/physiopathology
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    Human breast cancer: androgen action mediated by estrogen receptor (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Growth of the human breast cancer cell line MCF-7 is enhanced by androgens, but only at pharmacological concentrations. Although physiological concentrations of androgens translocate the androgen receptor into the nucleus, no mitogenic effects are observed. By contrast, pharmacological androgens translocate not only the androgen receptor but also the estrogen receptor, and at these high doses significantly increase both DNA and estrogen-dependent protein synthesis. We therefore propose that androgens stimulate MCF-7 cell growth not through the androgen receptor but rather through the estrogen receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zava, D T -- McGuire, W L -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):787-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622569" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/*pharmacology ; Breast Neoplasms/*metabolism ; Cell Line ; Cell Nucleus/drug effects/metabolism ; Cytoplasm/drug effects/metabolism ; Dihydrotestosterone/pharmacology ; Humans ; Receptors, Androgen/drug effects ; Receptors, Estrogen/drug effects/*physiology ; Receptors, Glucocorticoid/drug effects/metabolism ; Receptors, Progesterone/drug effects/metabolism ; Stimulation, Chemical ; Translocation, Genetic
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    Human auditory frequency-following responses to a missing fundamental (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: Both a complex tone perceived as a 365-hertz "missing fundamental" and a 365-hertz pure tone evoked 365-hertz far-field frequency-following responses. Narrow-band masking noise centered at 365 hertz attenuated the responses to the pure tone but not to the complex tone. Results support the concept that perception of the missing fundamental is based on periodic neural activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, J C -- Marsh, J T -- Greenberg, S -- Brown, W S -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):639-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675250" target="_blank"〉PubMed〈/a〉
    Keywords: Auditory Pathways/*physiology ; Evoked Potentials ; Humans ; Inferior Colliculi/*physiology ; Periodicity ; Pitch Discrimination/*physiology
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  • 175
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    United States population dose estimates for iodine-131 in the thyroid after the Chinese atmospheric nuclear weapons tests (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: Analysis of samples collected within the United States after the Chinese atmospheric nuclear weapons tests of 26 September and 17 November 1976 indicates that the radiation dose to the thyroid from iodine-131 in milk was predominant. A U.S. population dose to the thyroid of 68,000 man-rads was calculated for the iodine-131 fallout. The four excess thyroid cancers that are estimated to occur as a result of the September test during the next 45 years will be masked by the 380,000 cases of thyroid cancer which are expected to occur in the United States from all causes during the same interval.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, J M -- Broadway, J A -- Strong, A B -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):44-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/565079" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Air Pollution, Radioactive/analysis ; Animals ; Cattle ; Child ; Humans ; Infant ; Iodine Radioisotopes/*analysis ; Milk/analysis ; Neoplasms, Radiation-Induced/*etiology ; Radiation Monitoring ; Radioactive Fallout/*analysis ; Thyroid Neoplasms/epidemiology/*etiology ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 176
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    NAS saccharin report sweetens FDA position, but not by much (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):852-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715446" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; *Carcinogens ; Cocarcinogenesis ; Female ; Humans ; Male ; Risk ; Saccharin/*adverse effects ; United States ; United States Food and Drug Administration
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  • 177
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    Prostaglandin E1 inhibitis platelet aggregation by a pathway independent of adenosine 3',5'-monophosphate (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-14
    Description: Aggregation of human blood platelets induced by adenosine diphosphate or 1-epinephrine was inhibited when the platelets were suspended in plasma which had been previously exposed to an insolubilized omega-aminohexylagarose derivative of prostaglandin E1. This decrease of platelet aggregation was not accompanied by a change in the concentration of adenosine 3',5'-monophosphate (cyclic AMP) in platelets. The results demonstrate the existence of an alternative pathway independent of cyclic AMP for the inhibition of platelet aggregation by plasma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sinha, A K -- Colman, R W -- New York, N.Y. -- Science. 1978 Apr 14;200(4338):202-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204997" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/antagonists & inhibitors ; Cyclic AMP/*blood ; Epinephrine/antagonists & inhibitors ; Humans ; Plasma/physiology ; Platelet Aggregation/*drug effects ; Prostaglandins E, Synthetic/*pharmacology ; Sepharose/analogs & derivatives ; Solubility
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    Schizophrenic symptoms improve with apomorphine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tamminga, C A -- Schaffer, M H -- Smith, R C -- Davis, J M -- New York, N.Y. -- Science. 1978 May 5;200(4341):567-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347574" target="_blank"〉PubMed〈/a〉
    Keywords: Apomorphine/pharmacology/*therapeutic use ; Chronic Disease ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Male ; Nerve Endings/drug effects ; Receptors, Dopamine/drug effects ; Schizophrenia/*drug therapy
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  • 179
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    Foreign aid support of science and economic growth (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: The history of U.S. foreign aid support of science and technology in Latin America is examined and an attempt is made to evaluate the scientific and economic growth of that area in relation to the total foreign aid effort.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szmant, H H -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1173-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415363" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry ; Cost-Benefit Analysis ; Education ; History, 20th Century ; International Educational Exchange ; Latin America ; *Research Support as Topic ; *Science/history ; United States
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  • 180
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    Nitrite and nitrate are formed by endogenous synthesis in the human intestine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-30
    Description: Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification. These findings significantly alter our previous conceptions of human exposure to nitrite and suggest an even wider role for nitrite in the etiology of human cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tannenbaum, S R -- Fett, D -- Young, V R -- Land, P D -- Bruce, W R -- New York, N.Y. -- Science. 1978 Jun 30;200(4349):1487-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663630" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Dietary Proteins/metabolism ; Feces/metabolism ; Humans ; Ileostomy ; Intestines/*metabolism ; Male ; Nitrates/*metabolism/urine ; Nitrites/*metabolism
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  • 181
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    Medicine: meritorious or meretricious (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: In spite of remarkable advances in medical therapy and in the development of fantastic diagnostic devices, American society appears increasingly disenchanted with the physician. The paradox can be explained by the high cost of medical care, the overselling of medicine's capabilities, the expectation that the physician will be both ultrascientific and as emphathic as yesterday's doctor, and little recognition that the curing of one illness in the elderly exposes this group to other disease. Finally, though the physician is trained to manage illnesses, he is also given the excessively broad task of improving personal and societal practices disadvantageous to health.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ingelfinger, F J -- New York, N.Y. -- Science. 1978 May 26;200(4344):942-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644336" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Defensive Medicine ; Diagnosis ; Forecasting ; Health Services Misuse ; Humans ; *Medicine/standards/trends ; Physician-Patient Relations ; Preventive Medicine ; Therapeutics
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  • 182
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    Opiate effects after adrenocorticotropin or beta-endorphin injection in the periaqueductal gray matter of rats (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: Injections of adrenocorticotropic hormone (ACTH) into the periaqueductal gray matter of drug-naive rats resulted in a dose-dependent opiate abstinence syndrome characterized by fearful hyperreactivity and explosive motor behavior. Injecting shorter chains of ACTH caused attenuated forms of this behavior. Injections of beta-endorphin at this same site caused opposite behavior: sedative, analgestic, and catatonic. If the effects of morphine are mediated by two classes of receptor) and the other which is not stereospecific and naloxone-insensitive--the endogtor)--and the other which is not stereospecific and naloxone-insensitive the endogenous ligand of the second receptor may be ACTH. The neuropeptides ACTH and endorphin may be part of an integrated neuromodulatory system, and the opiate abstinence syndrome may be the result of an altered interaction between the two receptor systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacquet, Y F -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1032-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210506" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/administration & dosage/*pharmacology ; Animals ; Cerebral Aqueduct ; Cosyntropin/pharmacology ; Drug Interactions ; Endorphins/administration & dosage/*pharmacology ; Humans ; Injections ; Injections, Intraperitoneal ; Male ; Melanocyte-Stimulating Hormones/administration & dosage/pharmacology ; Morphine/administration & dosage/pharmacology ; Motor Activity/drug effects ; Naloxone/administration & dosage/pharmacology ; *Narcotics ; Rats ; Receptors, Opioid/drug effects ; Substance Withdrawal Syndrome/*chemically induced
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    Covalent immunoglobulin assembly in vitro: reactivity of light chain covalent dimers (L2) and blocked light chain monomers (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-10
    Description: Covalent light chain dimers (L2) and cysteine-blocked L chain monomers readily react with partially reduced heavy (H) chains. A rapid disappearance of these blocked L chain species is followed by the appearance of covalent intermediates-HL, H2, and H2L-leading to fully assembled H2L2. The mechanism of initial disulfide bond formation between heavy and light chains is disulfide interchange.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kazin, A R -- Beychok, S -- New York, N.Y. -- Science. 1978 Feb 10;199(4329):688-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415360" target="_blank"〉PubMed〈/a〉
    Keywords: Bence Jones Protein/metabolism ; Cysteine/metabolism ; Disulfides ; Humans ; *Immunoglobulin G/biosynthesis ; *Immunoglobulin Heavy Chains/biosynthesis ; *Immunoglobulin Light Chains/biosynthesis ; *Immunoglobulin gamma-Chains/biosynthesis ; *Immunoglobulin kappa-Chains/biosynthesis ; In Vitro Techniques ; Oxidation-Reduction ; Protein Conformation
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  • 184
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    Human flicker sensitivity: two stages of retinal diffusion (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-24
    Description: A well-known solution of the diffusion equation gives an exponential square-root function as the frequency response for a one-dimensional diffusion or transmission process. When two or more such processes are cascaded, the result is still an exponential square-root characteristic, but with a longer time constant. This seems to explain why flicker thresholds obey the Kelly-Veringa diffusion model at high frequencies, even though the psychophysically inferred diffusion process is much slower than the first stage of visual transduction measured by, for example, late receptor potentials. Two such stages in tandem are sufficient to account for the psychophysical data, because the psychophysical time constant is proportional to the square of the number of stages involved. In addition, the nonlinear behavior of flicker thresholds under intense light adaptation can be explained if the loss factor in the first stage is proportional to the amount of the photopigment bleached. Apparently the flicker thresholds are governed by first- and second-order retinal neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelly, D H -- Wilson, H R -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):896-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715449" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Diffusion ; Flicker Fusion/*physiology ; Humans ; Light ; Models, Biological ; Photoreceptor Cells/physiology ; Retina/*physiology ; Retinal Pigments/physiology ; Time Factors
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    International cancer congress: AAAS clearinghouse (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kiernan, B A -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):968.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684430" target="_blank"〉PubMed〈/a〉
    Keywords: Argentina ; *Congresses as Topic ; Human Rights ; Humans ; *Information Services ; International Cooperation ; *Neoplasms ; *Societies, Scientific ; United States
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  • 186
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    Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: A permanent human cell line that maintains the granulocytic characteristics of acute myelogenous leukemia cells has been established. The cells of this line form myeloid colonies in soft gel culture in the presence of human colony-stimulating activity. The cell line may be useful for studying human acute myelogenous leukemia and the mechanism of response to colony-stimulating activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koeffler, H P -- Golde, D W -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1153-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/306682" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; *Cell Line ; Chromosome Aberrations/genetics ; Chromosome Disorders ; Colony-Stimulating Factors/*pharmacology ; Glycoproteins/*pharmacology ; Granulocytes/pathology ; Humans ; Leukemia, Myeloid, Acute/genetics/*pathology ; Male ; Middle Aged ; Receptors, Antigen, B-Cell/analysis
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    Infertility: promising new treatments (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):200-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694526" target="_blank"〉PubMed〈/a〉
    Keywords: Bromocriptine/therapeutic use ; Clomiphene/therapeutic use ; Female ; Humans ; Infertility/psychology/*therapy ; Infertility, Female/etiology ; Male ; Ovulation ; Prolactin/blood
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  • 188
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    Psychophysical functions for perceived and remembered size (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-04-21
    Description: Separate groups of people estimated the sizes of perceived or of remembered objects. In three independent experiments, both sets of data were well fit by power functions, and the exponent was reliably smaller by remembered than for perceived size.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moyer, R S -- Bradley, D R -- Sorensen, M H -- Whiting, C -- Mansfield, D P -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635592" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Memory/*physiology ; Models, Biological ; Size Perception/*physiology
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  • 189
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    Plutonium in drinking water: effects of chlorination on its maximum permissible concentration (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: Soluble plutonium is oxidized to the Pi(VI) oxidation state by chlorine during water treatment. Under certain conditions Pi(VI) is readily absorbed from the gastrointestinal tract. It appears that due consideration has not been given to the effect that the presence of plutonium in this oxidation state may have on the maximum permissible concentration of plutonium in drinking water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larsen, R P -- Oldham, R D -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1008-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684421" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chlorine/*pharmacology ; *Environmental Exposure ; Humans ; Intestinal Absorption ; *Maximum Allowable Concentration ; Oxidation-Reduction ; Plutonium/*analysis ; Rats ; Solubility ; Water/*analysis ; Water Pollutants/*analysis ; Water Pollutants, Radioactive/*analysis ; Water Supply
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  • 190
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    Rearing regimen producing piglet diarrhea (rotavirus) and its relevance to acute infantile diarrhea (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Piglets were weaned when 1 day old and thus were denied further access to the antibodies supplied by their dam's milk. They were placed in a nursery in which contamination by the ubiquitous rotavirus steadily increased with continuous use causing a progressive increase in the incidence of vomiting, diarrhea, and death among the piglets. A similar syndrome involving an antigenically related rotavirus and analogous management practices occurs in human infants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lecce, J G -- King, M W -- Dorsey, W E -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):776-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203032" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/immunology ; Antibody Formation ; Child, Preschool ; Colostrum/immunology ; Diarrhea/immunology/microbiology/*veterinary ; Diarrhea, Infantile/immunology ; Humans ; Infant ; Rotavirus/immunology ; Swine ; Virus Diseases/immunology/microbiology/*veterinary ; Weaning
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  • 191
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    Niemann-Pick disease experimental model (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lullmann, H -- Lullmann-Rauch, R -- New York, N.Y. -- Science. 1978 May 5;200(4341):568-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/77041" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cyclohexanes ; *Disease Models, Animal ; Humans ; Niemann-Pick Diseases/*chemically induced ; *trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 192
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    Postprandial changes in the exhalation rate of radon produced in vivo (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: The rate of exhalation of radon by persons with long-standing radium burdens increases about twofold shortly after a meal. The increase is short-lived and "normal" values are regained in 1.5 to 2 hours. The effect may account in part for the poor reproducibility in estimates of the freely emanating part of the radium content.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rundo, J -- Markun, F -- Sha, J Y -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1211-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628836" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Breath Tests ; Circadian Rhythm ; *Eating ; Environmental Exposure ; Female ; Humans ; Male ; Radium/*metabolism ; Radon/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 193
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    Newborn minor physical anomalies predict short attention span, peer aggression, and impulsivity at age 3 (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: From a 5-to 10-minute newborn examination, behaviors of males at age 3 could be predicted. The number of minor physical anomalies, assessed soon after birth, was significantly related to a cluster of behaviors that are frequently labeled hyperactivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waldrop, M F -- Bell, R Q -- McLaughlin, B -- Halverson, C F Jr -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):563-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622559" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Multiple/*complications ; Aggression ; Attention ; Child, Preschool ; Humans ; Hyperkinesis/*diagnosis/etiology ; Infant, Newborn ; Male ; Motor Activity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 194
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    3-Methoxy-4-hydroxyphenylglycol in cerebrospinal fluid and vanillylmandelic acid in urine of humans with hypertension (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: 3-Methoxy-4-hydroxyphenylglycol (MHPG) was measured in lumbar spinal fluid of 20 subjects with hypertension of varied etiology and severity. There was a significant correlation between the concentration of MHPG and the severity of hypertension. However, changes in the concentration of vanillylmandelic acid in the urine of these subjects were insignificant. In six subjects, administration of clonidine or alpha-methyldopa, two centrally acting antihypertensive drugs, was associated with a significant lowering of MHPG concentrations. These data support the hypothesis that central catecholamines are involved in clinical hypertension.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saran, R K -- Sahuja, R C -- Gupta, N N -- Hasan, M -- Bhargava, K P -- Shanker, K -- Kishor, K -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):317-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635588" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Pressure/drug effects ; Clonidine/pharmacology ; Female ; Glycols/*cerebrospinal fluid ; Humans ; Hypertension/*metabolism ; Male ; Methoxyhydroxyphenylglycol/*cerebrospinal fluid ; Methyldopa/pharmacology ; Vanilmandelic Acid/*urine
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 195
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    Schistosoma mansoni: identification of chemicals that attract or trap its snail vector, Biomphalaria glabrata (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-08
    Description: A new bioassay for chemical attractants of aquatic snails demonstrated that Biomphalaria glabrata could be attracted to or trapped in the vicinity of homogenates of lettuce. Fractionation of homogenates revealed the amino acids glutamate and proline and the primary attractants. Attraction was specific for the L form of glutamate. Proline appeared to stimulate reproductive activity. Glutathione, gamma-aminobutyric acid, and a number of other compounds had no effect. Extracts of lyophilized snail tissue also attracted other snails and may thus contain pheromones. These results permit formulation and testing of controlled-release attractants designed to overcome the repellant effects of slow-release molluscicides, as well as the design of stimulants to be used with no-release poisons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Uhazy, L S -- Tanaka, R D -- MacInnis, A J -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):924-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684418" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/isolation & purification ; Animals ; Biomphalaria/parasitology/*physiology ; *Disease Vectors ; Food ; Humans ; Pest Control, Biological/*methods ; Pheromones/*isolation & purification ; Schistosoma mansoni ; Schistosomiasis/*prevention & control
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 196
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    Central nervous system dysfunction due to lead exposure (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: Central nervous system dysfunction was investigated in workers at a secondary lead smelter by means of performance tests. Correlations between test scores and zinc protoporphyrin levels, a biological indicator of lead toxicity, are statistically significant. This correlation should prove to be useful in current efforts to evaluate effects of lead exposure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valciukas, J A -- Lilis, R -- Fischbein, A -- Selikoff, I J -- Eisinger, J -- Blumberg, W E -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):465-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663669" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Behavior/physiology ; Central Nervous System/*physiopathology ; Environmental Exposure ; Humans ; Lead/blood ; Lead Poisoning/blood/*physiopathology ; Middle Aged ; Neurologic Examination/methods ; Occupational Diseases/*physiopathology ; Porphyrins/*blood ; Protoporphyrins/*blood ; Zinc/blood
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 197
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    Serum lipoprotein concentrations in cystic fibrosis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Two major classes of lipoproteins, low density and high density, are decreased in the serum of patients with cystic fibrosis; major apoproteins are also decreased. Since essential fatty acids and certain fat-soluble vitamins depend on lipoproteins for transport in the serum, knowledge of lipoprotein levels in cystic fibrosis patients could prove valuable in understanding (i) the basis for the abnormally low serum levels of these fatty acids and vitamins and (ii) the effects of therapies involving these molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaughan, W J -- Lindgren, F T -- Whalen, J B -- Abraham, S -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):783-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203033" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Carrier State/blood ; Child ; Child, Preschool ; Cystic Fibrosis/*blood ; Electrophoresis, Agar Gel ; Electrophoresis, Polyacrylamide Gel ; Female ; Humans ; Lipoproteins/*blood ; Lipoproteins, HDL/blood ; Lipoproteins, LDL/blood ; Lipoproteins, VLDL/blood ; Male
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  • 198
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    Amino acid sequence of the Fc region of a canine immunoglobulin M: interspecies homology for the IgM class (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: The amino acid structure for the Fc portion of a canine immunoglobulin mu chain was determined. The sequence was compared with those of two human mu chains, and a high degree of interspecies homology was observed. The preservation of primary structure between species is probably reflective of the unique functions associated with the immunoglobulin M class.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wasserman, R L -- Capra, J D -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1159-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653360" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Biological Evolution ; Dogs ; Humans ; *Immunoglobulin Fc Fragments ; *Immunoglobulin M ; Species Specificity
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  • 199
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    Computer use in diagnosis, prognosis, and therapy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: Computers are used to influence diagnostic and therapeutic decisions. The computer's information-handling capabilities allow it to serve as a reliable extension of the physician's memory and expander of the physician's information and synthesized knowledge resources. Computers have been used to facilitate decisions through organization of patient data, improved classification of patients, decision analysis in clinical settings, and simulation of expert clinical reasoning. Computer programs are more successful in narrow, constrained, single arenas of medicine with much underlying pathophysiologic understanding and where decisions are based largely on hard laboratory data. New models of synthetic reasoning that simulate expert clinical behavior show promise of supporting complicated decisions concerning problems of multiple diseases. All systems are confronted by problems of consensus and authority of the underlying information used.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schoolman, H M -- Bernstein, L M -- New York, N.Y. -- Science. 1978 May 26;200(4344):926-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347580" target="_blank"〉PubMed〈/a〉
    Keywords: *Computers ; Coronary Disease/diagnosis ; *Diagnosis, Computer-Assisted ; Diagnosis, Differential ; Humans ; Information Systems ; Medical Records, Problem-Oriented ; *Prognosis ; *Therapeutics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 200
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    Preferential utilization of free cholesterol from high-density lipoproteins for biliary cholesterol secretion in man (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: High- and low-density lipoproteins carrying free cholesterol labeled with 3H or 14C were administered to a patient with a bile fistula. The free cholesterol from high-density lipoproteins was more rapidly incorporated into biliary cholesterol than the free cholesterol from low-density lipoproteins. These findings show that the liver in man selectively utilizes and secretes the free cholesterol from a particular lipoprotein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, C C -- Halloran, L G -- Vlahcevic, Z R -- Gregory, D H -- Swell, L -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):62-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204996" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Bile/*metabolism ; Cholesterol/blood/*metabolism ; Coronary Disease/metabolism ; Erythrocytes/metabolism ; Female ; Humans ; Lipoproteins, HDL/*metabolism ; Lipoproteins, LDL/*metabolism ; Liver/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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