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  • 1
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    A mutation in APP protects against Alzheimer's disease and age-related cognitive decline (2012)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2012-07-18
    Beschreibung: The prevalence of dementia in the Western world in people over the age of 60 has been estimated to be greater than 5%, about two-thirds of which are due to Alzheimer's disease. The age-specific prevalence of Alzheimer's disease nearly doubles every 5 years after age 65, leading to a prevalence of greater than 25% in those over the age of 90 (ref. 3). Here, to search for low-frequency variants in the amyloid-beta precursor protein (APP) gene with a significant effect on the risk of Alzheimer's disease, we studied coding variants in APP in a set of whole-genome sequence data from 1,795 Icelanders. We found a coding mutation (A673T) in the APP gene that protects against Alzheimer's disease and cognitive decline in the elderly without Alzheimer's disease. This substitution is adjacent to the aspartyl protease beta-site in APP, and results in an approximately 40% reduction in the formation of amyloidogenic peptides in vitro. The strong protective effect of the A673T substitution against Alzheimer's disease provides proof of principle for the hypothesis that reducing the beta-cleavage of APP may protect against the disease. Furthermore, as the A673T allele also protects against cognitive decline in the elderly without Alzheimer's disease, the two may be mediated through the same or similar mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jonsson, Thorlakur -- Atwal, Jasvinder K -- Steinberg, Stacy -- Snaedal, Jon -- Jonsson, Palmi V -- Bjornsson, Sigurbjorn -- Stefansson, Hreinn -- Sulem, Patrick -- Gudbjartsson, Daniel -- Maloney, Janice -- Hoyte, Kwame -- Gustafson, Amy -- Liu, Yichin -- Lu, Yanmei -- Bhangale, Tushar -- Graham, Robert R -- Huttenlocher, Johanna -- Bjornsdottir, Gyda -- Andreassen, Ole A -- Jonsson, Erik G -- Palotie, Aarno -- Behrens, Timothy W -- Magnusson, Olafur T -- Kong, Augustine -- Thorsteinsdottir, Unnur -- Watts, Ryan J -- Stefansson, Kari -- HL-102924/HL/NHLBI NIH HHS/ -- HL-102925/HL/NHLBI NIH HHS/ -- HL-102926/HL/NHLBI NIH HHS/ -- HL-103010/HL/NHLBI NIH HHS/ -- England -- Nature. 2012 Aug 2;488(7409):96-9. doi: 10.1038/nature11283.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22801501" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aging/*genetics ; Alleles ; Alzheimer Disease/*genetics/pathology/physiopathology/prevention & control ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Protein Precursor/chemistry/*genetics/*metabolism ; Aspartic Acid Endopeptidases/metabolism ; Cognition/physiology ; Cognition Disorders/*genetics/*physiopathology/prevention & control ; Genetic Predisposition to Disease ; HEK293 Cells ; Humans ; Mutation/*genetics ; Plaque, Amyloid/genetics/metabolism
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
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  • 2
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    Basin-scale phenology and effects of climate variability on global timing of initial seaward migration of Atlantic salmon (Salmo salar) (2013)
    Jaime Otero, Jan Henning L'Abée-Lund, Ted Castro-Santos, Kjell Leonardsson, Geir O. Storvik, Bror Jonsson, J. Brian Dempson, Ian C. Russell, Arne J. Jensen, Jean-Luc Baglinière, Mélanie Dionne, John D. Armstrong, Atso Romakkaniemi, Benjamin H. Letcher, John F. Kocik, Jaakko Erkinaro, Russell Poole, Ger Rogan, Hans Lundqvist, Julian C. Mac; Lean, Erkki Jokikokko, Jo Vegar Arnekleiv, Richard J. Kennedy, Eero Niemelä, Pablo Caballero, Paul A. Music, Thorolfur Antonsson, Sigurdur Gudjonsson, Alexey E. Veselov, Anders Lamberg, Steve Groom, Benjamin H. Taylor, Malcolm Taberner, Mary Dillane, Fridthjofur Arnason, Gregg Horton, Nils A. Hvidsten, Ingi R. Jonsson, Nina Jonsson, Simon McKelvey, Tor F. Næsje, Øystein Skaala, Gordon W. Smith, Harald Sægrov, Nils C. Stenseth, Leif Asbjørn Vøllestad
    Wiley
    Details
    Publikationsdatum: 2013-08-23
    Beschreibung: Migrations between different habitats are key events in the lives of many organisms. Such movements involve annually recurring travel over long distances usually triggered by seasonal changes in the environment. Often, the migration is associated with travel to or from reproduction areas to regions of growth. Young anadromous Atlantic salmon ( Salmo salar ) emigrate from freshwater nursery areas during spring and early summer to feed and grow in the North Atlantic Ocean. The transition from the freshwater (‘parr’) stage to the migratory stage where they descend streams and enter salt water (‘smolt’) is characterized by morphological, physiological and behavioural changes where the timing of this parr-smolt transition is cued by photoperiod and water temperature. Environmental conditions in the freshwater habitat control the downstream migration and contribute to within- and among-river variation in migratory timing. Moreover, the timing of the freshwater emigration has likely evolved to meet environmental conditions in the ocean as these affect growth and survival of the post-smolts. Using generalized additive mixed-effects modelling, we analysed spatio-temporal variations in the dates of downstream smolt migration in 67 rivers throughout the North Atlantic during the last five decades and found that migrations were earlier in populations in the east than the west. After accounting for this spatial effect, the initiation of the downstream migration among rivers was positively associated with freshwater temperatures, up to about 10 °C and levelling off at higher values, and with sea-surface temperatures. Earlier migration occurred when river discharge levels were low but increasing. On average, the initiation of the smolt seaward migration has occurred 2.5 days earlier per decade throughout the basin of the North Atlantic. This shift in phenology matches changes in air, river, and ocean temperatures, suggesting that Atlantic salmon emigration is responding to the current global climate changes. This article is protected by copyright. All rights reserved.
    Print ISSN: 1354-1013
    Digitale ISSN: 1365-2486
    Thema: Biologie , Energietechnik , Geographie
    Publiziert von Wiley
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  • 3
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    Sequence variants at the TERT-CLPTM1L locus associate with many cancer types (2009)
    Springer Nature
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    Publikationsdatum: 2009-01-18
    Print ISSN: 1061-4036
    Digitale ISSN: 1546-1718
    Thema: Biologie , Medizin
    Publiziert von Springer Nature
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  • 4
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    Basin-scale phenology and effects of climate variability on global timing of initial seaward migration of Atlantic salmon (Salmo salar) (2013)
    Wiley
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    Publikationsdatum: 2013-11-21
    Print ISSN: 1354-1013
    Digitale ISSN: 1365-2486
    Thema: Biologie , Energietechnik , Geographie
    Publiziert von Wiley
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  • 5
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    Optimal size at seaward migration in an anadromous salmonid (2016)
    Inter-Research
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    Publikationsdatum: 2016-11-09
    Print ISSN: 0171-8630
    Digitale ISSN: 1616-1599
    Thema: Biologie
    Publiziert von Inter-Research
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  • 6
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    Migratory Atlantic salmon as vectors for the transfer of energy and nutrients between freshwater and marine environments (2003)
    Oxford, UK : Blackwell Science Ltd
    Freshwater biology 48 (2003), S. 0 
    Details
    ISSN: 1365-2427
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: SUMMARY 1. Annual energy, carbon, nitrogen and phosphorus fluxes across the river mouth by Atlantic salmon were estimated for 18 years (1976–94) in the Norwegian River Imsa. The total energy content of the emigrating smolts in each year varied considerably with a mean value of 237 × 103 kJ. That of returning adults also varied between years with a mean value of 141 × 104 kJ. One-sea-winter salmon (grilse) made up 65% of the total energy content of the spawners in the river. Dead carcasses remaining in the river after spawning were estimated to have a mean annual energy content of 175 × 103 kJ.2. The net annual energy flux from the sea to the river varied between 48 × 103 kJ (1987) and 152 × 104 kJ (1989) with a mean of 616 × 103 kJ, and a coefficient of variation of 67%. Average net marine import of the returning adults was 83 × 104 kJ year−1 with a coefficient of variation of 52%. Mean annual export of C, N and P to sea by the smolts was 595, 131 and 22 kg, and by kelts 1535, 352 and 70 kg, respectively, whereas gross import via the adults was 3176 kg C, 735 kg N and 132 kg P. The annual flux across the river mouth was 1046 kg C, 253 kg N and 39 kg P. The net marine import were 1585 kg C, 371 kg N and 60 kg P. The net flux was estimated at 0.2% for nitrogen and 5% for phosphorus of the total river load.3. The energy flux caused by Atlantic salmon spawning in the River Imsa was relatively high because the general nutrient load in the river is low. Thus, even though most Atlantic salmon survive spawning, their contribution to the nutrient flux in the river is significant.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2427.2003.00964.x
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  • 7
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    Migration of anadromous brown trout Salmo trutta in a Norwegian river (2002)
    Oxford UK : Blackwell Science Ltd
    Freshwater biology 47 (2002), S. 0 
    Details
    ISSN: 1365-2427
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: 1. Upstream and downstream migrating anadromous brown trout Salmo trutta were monitored daily in fish traps in the River Imsa in south-western Norway for 24 years, from 1976 to 1999. One-third of the fish descended to sea during spring (February–June) and two-thirds during autumn (September–January).2. In spring, high water temperature appeared to influence the downstream descent. Large brown trout (〉 30 cm, chiefly two or more sea sojourns) descended earlier and appeared less dependent on high water temperature than smaller and younger fish. The spring water flow was generally low and of little importance for the descent.3. In autumn, the daily number of descending brown trout correlated positively with flow and negatively with water temperature.4. Brown trout ascended from the sea between April and December, but more than 70% ascended between August and October. The number of ascending trout increased significantly with both decreasing temperature and flow during the autumn. This response to flow appeared to be the result of the autumn discharge which is generally high and most fish ascended at an intermediate flow of 7.5–10 m3 s−1 (which is low for the season).5. In a river like the Imsa with low spring and high autumn flows, water temperature appears to be the main environmental factor influencing the timing and rate of spring descent, while both water temperature and flow seemed to influence the timing and rate of the autumn descent and ascent. These relationships make sea trout migrations susceptible to variation in climate and human impacts of the flow regime in rivers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2427.2002.00873.x
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  • 8
    Digitale Medien
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    Potential for sea ranching rainbow trout, Oncorhynchus mykiss (Walbaum): evidence from trials in two Norwegian fjords (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Aquaculture research 24 (1993), S. 0 
    Details
    ISSN: 1365-2109
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract. In total, 10014 hatchery-reared 1+ and 2+ rainbow trout, Oncorhynchus mykiss (Walbaum), were released near the mouth of the River Imsa, south-western Norway, and in the Oslofjord, south-eastern Norway. The reported recapture rate was significantly higher in the Oslofjord(15·4%) than at Ims(3·6%). Between 70 and 80% of the recaptures were made in the year of release. The fish were recaptured in rivers and the sea along the Norwegian coast, most of them near the release sites. In total, 60% were recaptured in salt water and 40% in fresh water. Fish released in the Oslofjord were largely captured with rod and line. Of those released at Ims most of the freshwater recaptures were made in a fish trap in the River Imsa. In salt water most fish were captured by nets. Specific growth rate varied inversely with body weight at release, decreased with time after release and decreased faster for fish released in the Oslofjord than at Ims. In general, the proportion of fish recaptured increased with mean fish weight at release. Recaptured biomass per 1000 fish released was higher when released in the Oslofjord (87·12kg) than at Ims (24·42kg). Stocking of rainbow trout in fjords is feasible and may contribute to local recreational fisheries. Yield was highest when relatively small (∼50g) fish were released. Economically, the best results may be obtained when the fish are released in nutrient rich fjords.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2109.1993.tb00641.x
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  • 9
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    Coastal movement and growth of domesticated rainbow trout (Oncorhynchus mykiss (Walbaum)) in Norway (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Ecology of freshwater fish 2 (1993), S. 0 
    Details
    ISSN: 1600-0633
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Between 1979 and 1991, hatchery-reared 1+ and 2+ rainbow trout were released in May and June in the Boknafjord at the mouth of the River Imsa, and from April to June in the Oslofjord, southern Norway. The fish were recaptured in the fjords of release, in rivers emptying there and from rivers and sea further along the Norwegian coast. Of the total recaptures, 35.6% ascended rivers in the year of release. Some fish released at the River Imsa returned to the area of release after spending 1 to 3 years at sea. Among those that were recaptured in rivers, 11.9% were recaptured in other rivers than the Imsa. The growth rate of the fish varied inversely with size at release. The growth rate was higher in the Oslofjord than in the Boknafjord, and in both areas the growth rate decreased with time after release. Rainbow trout that had escaped from local fish farms entered the River Imsa between March and December. Adults ascending in spring remained a shorter time in the river (37 days) than those ascending in autumn (200 days). Fish entering in autumn decreased more in weight during their river stay than those ascending in spring, and females more than males. Spawning took place in April-May. The monthly mean river stay of juvenile entrants ranged from 2 weeks to 6 months. In total, 27.8% of the rainbow trout escaped from fish farms and captured in the Imsa strayed to other rivers for repeat spawning. There is no evidence for continuing survival of escaped Norwegian rainbow trout in the wild.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0633.1993.tb00097.x
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  • 10
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    Atlantic salmon Salmo salar L., brown trout Salmo trutta L. and Arctic charr Salvelinus alpinus (L.): a review of aspects of their life histories (2003)
    Oxford, UK : Blackwell Science, Ltd
    Ecology of freshwater fish 12 (2003), S. 0 
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    ISSN: 1600-0633
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract  – Among the species in the family Salmonidae, those represented by the genera Salmo, Salvelinus, and Oncorhynchus (subfamily Salmoninae) are the most studied. Here, various aspects of phenotypic and life-history variation of Atlantic salmon Salmo salar L., brown trout Salmo trutta L., and Arctic charr Salvelinus alpinus (L.) are reviewed. While many strategies and tactics are commonly used by these species, there are also differences in their ecology and population dynamics that result in a variety of interesting and diverse topics that are challenging for future research. Atlantic salmon display considerable phenotypic plasticity and variability in life-history characters ranging from fully freshwater resident forms, where females can mature at approximately 10 cm in length, to anadromous populations characterised by 3–5 sea-winter (5SW) salmon. Even within simple 1SW populations, 20 or more spawning life-history types can be identified. Juveniles in freshwater can use both fluvial and lacustrine habitats for rearing, and while most smolts migrate to sea during the spring, fall migrations occur in some populations. At sea, some salmon undertake extensive oceanic migrations while other populations stay within the geographical confines of areas such as the Baltic Sea. At the other extreme are those that reside in estuaries and return to freshwater to spawn after spending only a few months at sea. The review of information on the diversity of life-history forms is related to conservation aspects associated with Atlantic salmon populations and current trends in abundance and survival. Brown trout is indigenous to Europe, North Africa and western Asia, but was introduced into at least 24 countries outside Europe and now has a world-wide distribution. It exploits both fresh and salt waters for feeding and spawning (brackish), and populations are often partially migratory. One part of the population leaves and feeds elsewhere, while another part stays as residents. In large, complex systems, the species is polymorphic with different size morphs in the various parts of the habitat. Brown trout feed close to the surface and near shore, but large individuals may move far offshore. The species exhibits ontogenetic niche shifts partly related to size and partly to developmental rate. They switch when the amount of surplus energy available for growth becomes small with fast growers being younger and smaller fish than slow growers. Brown trout is an opportunistic carnivore, but individuals specialise at least temporarily on particular food items; insect larvae are important for the young in streams, while littoral epibenthos in lakes and fish are most important for large trout. The sexes differ in resource use and size. Females are more inclined than males to become migratory and feed in pelagic waters. Males exploit running water, near-shore and surface waters more than females. Therefore, females feed more on zooplankton and exhibit a more uniform phenotype than males. The Arctic charr is the northernmost freshwater fish on earth, with a circumpolar distribution in the Holarctic that matches the last glaciation. Recent mtDNA studies indicate that there are five phylogeographic lineages (Atlantic, Arctic, Bering, Siberian and Acadian) that may be of Pleistocene origin. Phenotypic expression and ecology are more variable in charr than in most fish. Weights at maturation range from 3 g to 12 kg. Population differences in morphology and coloration are large and can have some genetic basis. Charr live in streams, at sea and in all habitats of oligotrophic lakes, including very deep areas. Ontogenetic habitat shifts between lacustrine habitats are common. The charr feed on all major prey types of streams, lakes and near-shore marine habitats, but has high niche flexibility in competition. Cannibalism is expressed in several cases, and can be important for developing and maintaining bimodal size distributions. Anadromy is found in the northern part of its range and involves about 40, but sometimes more days in the sea. All charr overwinter in freshwater. Partial migration is common, but the degree of anadromy varies greatly among populations. The food at sea includes zooplankton and pelagic fish, but also epibenthos. Polymorphism and sympatric morphs are much studied. As a prominent fish of glaciated lakes, charr is an important species for studying ecological speciation by the combination of field studies and experiments, particularly in the fields of morphometric heterochrony and comparative behaviour.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1034/j.1600-0633.2003.00010.x
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