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  • 1
    Monographie ausleihbar
    Monographie ausleihbar
    Oxford [u.a.] : Oxford Univ. Press
    Signatur: PIK N 073-10-0195 ; IASS 12.0087
    Beschreibung / Inhaltsverzeichnis: Contents: A. Overview ; 1: 'Ethics and Global Climate Change' ; B. The Nature of the Problem ; 2: 'The Economics of Climate Change' ; 3: 'Ethics, Public Policy and Global Warming' ; 4: 'A Perfect Moral Storm: Climate Change, Intergenerational Ethics and the Problem of Moral Corruption' ; C: Global Justice and Future Generations ; 5: 'Global Environment and International Inequality' ; 6: 'Energy Policy and the Further Future: The Identity Problem' ; 7: 'Cosmopolitan Justice, Responsibility and Global Climate Change' ; 8: 'Deadly Delays, Saving Opportunities: Creating a More Dangerous World?' ; 9: 'Climate Change, Human Rights and Moral Thresholds' ; D: Policy Responses to Climate Change ; 10: 'One Atmosphere' ; 11: 'Subsistence Emissions and Luxury Emissions' ; 12: 'Greenhouse Development Rights: A Framework for Climate Protection that is "More Fair" than Equal per Capita Emissions Rights' ; 13: 'Selling Environmental Indulgences' ; 14: 'Adaptation: Who Pays Whom?' ; 15: Adaptation, Mitigation, and Justice' ; 16: 'Is "Arming the Future" with Geoengineering Really the Lesser Evil? Some Doubts About the Ethics of Intentionally Manipulating the Climate System' ; E. Individual Responsibility ; 17: 'When Utilitarians Should be Virtue Theorists' ; 18: 'It's Not My Fault: Global Warming and Individual Moral Obligations'
    Materialart: Monographie ausleihbar
    Seiten: XVI, 351 S. : graph. Darst.
    ISBN: 9780195399615
    Standort: A 18 - Bitte bestellen
    Zweigbibliothek: PIK Bibliothek
    Zweigbibliothek: RIFS Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Schriftenreihen ausleihbar
    Schriftenreihen ausleihbar
    Ottawa : Geological Survey of Canada
    Dazugehörige Bände
    Signatur: SR 90.0008(87-13)
    In: Paper
    Materialart: Schriftenreihen ausleihbar
    Seiten: 11 S. + 1 pl.
    ISBN: 0660124483
    Serie: Paper / Geological Survey of Canada 87-13
    Sprache: Englisch
    Standort: Kompaktmagazin unten
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Signatur: 9/M 07.0421(461)
    In: Geological Society Special Publication
    Materialart: Monographie ausleihbar
    Seiten: 255 Seiten , Illustrationen
    ISBN: 9781786203229
    Serie: Geological Society Special Publication 461
    Klassifikation:
    Historische Geologie
    Sprache: Englisch
    Standort: Lesesaal
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Schlagwort(e): Antarctica ; glaciology ; subglacial Antarctica ; subglacial mountains ; subglacial lakes ; subglacial volcanoes ; glacier mass loss
    Beschreibung / Inhaltsverzeichnis: Exploration of subsurface Antarctica: uncovering past changes and modern processes / Martin J. Siegert, Stewart S. R. Jamieson and Duanne White / Geological Society, London, Special Publications, 461, 1-6, 25 September 2017, https://doi.org/10.1144/SP461.15 --- A 60-year international history of Antarctic subglacial lake exploration / Martin J. Siegert / Geological Society, London, Special Publications, 461, 7-21, 25 May 2017, https://doi.org/10.1144/SP461.5 --- Exploring the Recovery Lakes region and interior Dronning Maud Land, East Antarctica, with airborne gravity, magnetic and radar measurements / Rene Forsberg, Arne V. Olesen, Fausto Ferraccioli, Tom A. Jordan, Kenichi Matsuoka, Andres Zakrajsek, Marta Ghidella and Jamin S. Greenbaum / Geological Society, London, Special Publications, 461, 23-34, 20 September 2017, https://doi.org/10.1144/SP461.17 --- Ice-flow reorganization within the East Antarctic Ice Sheet deep interior / L. H. Beem, M. G. P. Cavitte, D. D. Blankenship, S. P. Carter, D. A. Young, G. R. Muldoon, C. S. Jackson and M. J. Siegert / Geological Society, London, Special Publications, 461, 35-47, 11 August 2017, https://doi.org/10.1144/SP461.14 --- Was South Georgia covered by an ice cap during the Last Glacial Maximum? / Duanne A. White, Ole Bennike, Martin Melles, Sonja Berg and Steven A. Binnie / Geological Society, London, Special Publications, 461, 49-59, 13 June 2017, https://doi.org/10.1144/SP461.4 --- The Gebra–Magia Complex: mass-transport processes reworking trough-mouth fans in the Central Bransfield Basin (Antarctica) / D. Casas, M. García, F. Bohoyo, A. Maldonado and G. Ercilla / Geological Society, London, Special Publications, 461, 61-75, 16 June 2017, https://doi.org/10.1144/SP461.10 --- Bathymetry of Schirmacher lakes as a tool for geomorphological evolution studies / Ashit Kumar Swain / Geological Society, London, Special Publications, 461, 77-93, 11 July 2017, https://doi.org/10.1144/SP461.13 --- Heavy mineral assemblage of marine sediments as an indicator of provenance and east antarctic ice sheet fluctuations / Mayuri Pandey, Naresh C. Pant, Paromita Biswas, Prakash K. Shrivastava, Sonalika Joshi and Neety Nagi / Geological Society, London, Special Publications, 461, 95-111, 22 June 2017, https://doi.org/10.1144/SP461.2 --- Position and variability of complex structures in the central East Antarctic Ice Sheet / Thilo Wrona, Michael J. Wolovick, Fausto Ferraccioli, Hugh Corr, Tom Jordan and Martin J. Siegert / Geological Society, London, Special Publications, 461, 113-129, 15 June 2017, https://doi.org/10.1144/SP461.12 --- Summit of the East Antarctic Ice Sheet underlain by thick ice-crystal fabric layers linked to glacial–interglacial environmental change / Bangbing Wang, Bo Sun, Carlos Martin, Fausto Ferraccioli, Daniel Steinhage, Xiangbin Cui and Martin J. Siegert / Geological Society, London, Special Publications, 461, 131-143, 26 May 2017, https://doi.org/10.1144/SP461.1 --- Drilling project at Gamburtsev Subglacial Mountains, East Antarctica: recent progress and plans for the future / Pavel Talalay, Youhong Sun, Yue Zhao, Yuansheng Li, Pinlu Cao, Alexey Markov, Huiwen Xu, Rusheng Wang, Nan Zhang, Xiaopeng Fan, Yang Yang, Mikhail Sysoev, Yongwen Liu and Yunchen Liu / Geological Society, London, Special Publications, 461, 145-159, 24 May 2017, https://doi.org/10.1144/SP461.9 --- A deep subglacial embayment adjacent to the grounding line of Institute Ice Stream, West Antarctica / Hafeez Jeofry, Neil Ross, Hugh F. J. Corr, Jilu Li, Prasad Gogineni and Martin J. Siegert / Geological Society, London, Special Publications, 461, 161-173, 13 June 2017, https://doi.org/10.1144/SP461.11 --- Ocean forced variability of Totten Glacier mass loss / Jason Roberts, Benjamin K. Galton-Fenzi, Fernando S. Paolo, Claire Donnelly, David E. Gwyther, Laurie Padman, Duncan Young, Roland Warner, Jamin Greenbaum, Helen A. Fricker, Antony J. Payne, Stephen Cornford, Anne Le Brocq, Tas van Ommen, Don Blankenship and Martin J. Siegert / Geological Society, London, Special Publications, 461, 175-186, 23 August 2017, https://doi.org/10.1144/SP461.6 --- Chemical characteristics of the ice cores obtained after the first unsealing of subglacial Lake Vostok / Irina Alekhina, Alexey Ekaykin, Alexey Moskvin and Vladimir Lipenkov / Geological Society, London, Special Publications, 461, 187-196, 24 May 2017, https://doi.org/10.1144/SP461.3 --- Antarctic subglacial groundwater: a concept paper on its measurement and potential influence on ice flow / Martin J. Siegert, Bernd Kulessa, Marion Bougamont, Poul Christoffersen, Kerry Key, Kristoffer R. Andersen, Adam D. Booth and Andrew M. Smith / Geological Society, London, Special Publications, 461, 197-213, 25 May 2017, https://doi.org/10.1144/SP461.8 --- Modern to Glacial age subglacial meltwater drainage at Law Dome, coastal East Antarctica from topography, sediments and jökulhlaup observations / Ian D. Goodwin, Jason L. Roberts, David M. Etheridge, John Hellstrom, Andrew D. Moy, Marta Ribo and Andrew M. Smith / Geological Society, London, Special Publications, 461, 215-230, 12 July 2017, https://doi.org/10.1144/SP461.16 --- A new volcanic province: an inventory of subglacial volcanoes in West Antarctica / Maximillian van Wyk de Vries, Robert G. Bingham and Andrew S. Hein / Geological Society, London, Special Publications, 461, 231-248, 29 May 2017, https://doi.org/10.1144/SP461.7
    Seiten: Online-Ressource (VI, 255 Seiten) , Diagramme, Karten
    ISBN: 9781786203229
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Beschreibung / Inhaltsverzeichnis: Arsenic is perhaps history’s favorite poison, often termed the "King of Poisons" and the "Poison of Kings" and thought to be the demise of fiction’s most famous ill-fated lovers. The toxic nature of arsenic has been known for millennia with the mineral realgar (AsS), originally named “arsenikon” by Theophrastus in 300 B.C.E. meaning literally "potent." For centuries it has been used as rat poison and as an important component of bactericides and wood preservatives. Arsenic is believed to be the cause of death to Napoleon Bonaparte who was exposed to wallpaper colored green from aceto-arsenite of copper (Aldersey-Williams 2011). The use of arsenic as a poison has been featured widely in literature, film, theatre, and television. Its use as a pesticide made it well known in the nineteenth century and it was exploited by Sir Arthur Conan Doyle in the Sherlock Holmes novel The Golden Pince-Nez (Conan-Doyle 1903). The dark comedy Arsenic and Old Lace is a prime example of arsenic in popular culture, being first a play but becoming famous as a movie. Arsenic has figured prominently not only in fiction but in historical crimes as well (Kumar 2010). A high profile case of the mid-nineteenth century involved a hydrotherapist, Dr. Thomas Smethurst, who was accused of using arsenic to poison a woman he had befriended (Wharton 2010). Based on analytical evidence from a renowned toxicologist, Alfred Swaine Taylor, a death sentence was imposed, however Taylor had to confess that his apparatus was contaminated. The verdict was overturned after public opinion was voiced against it and a plea for clemency was made to Queen Victoria. In recent years, arsenic has been recognized as a widespread, low-level, natural groundwater contaminant in many parts of the world, particularly in places such as West Bengal and Bangladesh, where it has given rise to chronic human-health issues. Long-term exposure to arsenic has been shown to cause skin lesions, blackfoot disease, and cancer of the skin, bladder, and lungs, and is also associated with developmental effects, cardiovascular disease, neurotoxicity, and diabetes (WHO 2012). Arsenate’s toxicity is caused by its close chemical similarities to phosphate; it uses a phosphate transport system to enter cells. Arsenic occurs in many geological environments including sedimentary basins, and is particularly associated with geothermal waters and hydrothermal ore deposits. It is often a useful indicator of proximity to economic concentrations of metals such as gold, copper, and tin, where it occurs in hydrothermally altered wall rocks surrounding the zones of economic mineralization. Arsenic is commonly a persistent problem in metal mining and there has been significant effort to manage and treat mine waste to mitigate its environmental impacts. This volume compiles and reviews current information on arsenic from a variety of perspectives, including mineralogy, geochemistry, microbiology, toxicology, and environmental engineering. The first chapter (Bowell et al. 2014) presents an overview of arsenic geochemical cycles and is followed by a chapter on the paragenesis and crystal chemistry of arsenic minerals (chapter 2; Majzlan et al. 2014). The next chapters deal with an assessment of arsenic in natural waters (chapter 3; Campbell and Nordstrom 2014) and a review of thermodynamics of arsenic species (chapter 4; Nordstrom et al. 2014). The next two chapters deal with analytical measurement and assessment starting with measuring arsenic speciation in solids using x-ray absorption spectroscopy (chapter 5; Foster and Kim 2014). Chapter 6 (Leybourne and Johannesson 2014) presents a review on the measurement of arsenic speciation in environmental media: sampling, preservation, and analysis. In chapter 7 (Amend et al. 2014) there is a review of microbial arsenic metabolism and reaction energetics. This is followed by an overview of arsenic toxicity and human health issues (chapter 8; Mitchell 2014) and an assessment of methods used to characterize arsenic bioavailability and bioaccessibility (chapter 9; Basta and Jurasz 2014). This leads into chapter 10 (Craw and Bowell 2014), which describes the characterization of arsenic in mine waste with some examples from New Zealand, followed by a chapter on the management and treatment of arsenic in mining environments (chapter 11; Bowell and Craw 2014). The final three chapters are in-depth case studies of the geochemistry and mineralogy of legacy arsenic contamination in different historical mining environments: the Giant gold mine in Canada (chapter 12; Jamieson 2014), the Sierra Nevada Foothills gold belt of California (chapter 13; Alpers et al. 2014), and finally, the hydrogeochemistry of arsenic in the Tsumeb polymetallic mine in Namibia (chapter 14; Bowell 2014).
    Seiten: Online-Ressource (xvi ; 635 Seiten)
    ISBN: 9780939950942
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
  • 7
    Digitale Medien
    Digitale Medien
    Amsterdam : Elsevier
    Phytochemistry 15 (1976), S. 1713-1715 
    ISSN: 0031-9422
    Schlagwort(e): Compositae ; Petasites ; fatty acids, bakkenolide-A, chemotaxonomy, cytotoxicity ; transformed cells.
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Publikationsdatum: 2002-05-01
    Print ISSN: 0168-583X
    Digitale ISSN: 1872-9584
    Thema: Physik
    Publiziert von Elsevier
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Publikationsdatum: 1976-01-01
    Print ISSN: 0031-9422
    Digitale ISSN: 1873-3700
    Thema: Biologie , Chemie und Pharmazie
    Publiziert von Elsevier
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Publikationsdatum: 2009-11-20
    Beschreibung: Abstract 3275 Poster Board III-1 Introduction: Leukemia stem cells (LSC) are rare, self-renewing cells capable of proliferation and differentiation into the bulk of cells that make up a leukemia. LSC, like normal tissue-specific stem cells, can be highly quiescent and resistant to apoptosis induced by drugs and radiotherapy that target rapidly dividing cells. While traditional chemotherapy may successfully eradicate the bulk of tumor cells, it often fails to kill LSC resulting in their reactivation and eventual relapse of disease. Apoptosis resistance in cancer often involves deregulation of Bcl-2 family proteins. Bcl-2 family expression also seems to have an important role in normal stem cell function as expression changes of Mcl-1, Bcl-2, and Bcl-XL in mouse hematopoietic stem and progenitors characterize the differentiation of hematopoietic cells to different lineages. Several studies have linked expression of Bcl-2 family members to the development of blast crisis chronic myeloid leukemia (BC CML) in vitro, however there has been little data on the role of Bcl-2 expression in apoptosis resistance in human LSC. Also, various data has shown that CML cells become increasingly resistant to BCR-ABL inhibition with progression to blast crisis. In BC CML, LSC are enriched in the progenitor population and can be serially transplanted in immunodeficient mice leading to BC CML in vivo. We hypothesize that human BC CML LSC may resist chemotherapy by overexpression of Bcl-2 family proteins and maintenance of quiescence. We analyzed Bcl-2 family protein expression in BC CML LSC and analyzed whether these cells were sensitive to chemotherapy treatment in vitro. We further analyzed whether BC CML LSC could maintain quiescence in vivo. Finally, we tested the efficacy of the broad spectrum Bcl-2 antagonist apogossypol on BC CML LSC in vitro and in vivo. Methods: Bcl-2 and Mcl-1 protein expression was measured in 1° BC CML LSC by intracellular FACS analysis and compared to expression in normal and chronic phase CML cells. CD34+ cells isolated from serially transplanted BC CML LSC were used for all subsequent studies. To assess whether BC CML cells maintained quiescence in vivo, they were stained with DiR, an infrared fluorescent cell membrane dye, transplanted into neonatal mice, and analyzed for DiR fluorescence 18 weeks later. Dividing cells will distribute DiR to all daughter cells leading to dilution of the dye and a decrease in fluorescent signal per cell. LSC drug resistance was tested in vitro by culturing the cells with etoposide, dasatinib, and apogossypol and by measuring apoptosis by FACS using annexin-V/7-AAD staining. Finally, apogossypol efficacy was tested in vivo in LSC transplanted mice. At 8 weeks post-transplantation, mice were treated for 3 weeks with apogossypol or vehicle and then analyzed for human hematopoietic cell engraftment and apoptosis by FACS. Results: 1° BC CML progenitors expressed significantly higher levels of Bcl-2 and Mcl-1 protein compared to normal cord blood and chronic phase CML cells. LSC cultured in vitro were also resistant to etoposide and dasatinib-induced apoptosis. Apogossypol treatment in vitro however led to a dose-dependent increase in cell death and apoptosis and resulted in a significant increase in the frequency of lin+ staining cells along with a significant shift in the frequency of the common myeloid progenitor (CMP) and granulocyte-macrophage progenitor (GMP) populations compared to vehicle treated controls. Mice transplanted with BC CML LSC developed diffuse myeloid sarcomas and had high levels of human engraftment in the liver, spleen, and bone marrow. Human cells in tumors and the liver were uniformly DiR- while cells engrafted in the spleen and bone marrow retained DiR fluorescence. In vivo treatment with apogossypol led to a significant reduction in human cell engraftment in mouse bone marrow compared to vehicle controls. Consistent with the results in vitro, there was also a significant increase in the frequency of lin+ staining cells in engrafted mouse spleens as well as a significant decrease in engrafted GMP in the mouse bone marrow. Conclusions: Our results demonstrate that BC CML LSC are highly resistant to conventional chemotherapy but are sensitive to apogossypol in vitro and in vivo. Broad-spectrum inhibition of Bcl-2 family proteins may help to eliminate CML LSC by inducing apoptosis as well as by inducing differentiation. Disclosures: Goff: Coronado Biosciences: Research Funding. Tesi:Coronado Biosciences: President and CEO. Jamieson:Coronado Biosciences: Research Funding. Jamieson:Coronado Biosciences: Research Funding.
    Print ISSN: 0006-4971
    Digitale ISSN: 1528-0020
    Thema: Biologie , Medizin
    Standort Signatur Erwartet Verfügbarkeit
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