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  • 1
    Electronic Resource
    Electronic Resource
    Does geographic range affect the attractant–aggregation–attachment pheromone of the tropical bont tick, Amblyomma variegatum? (2000)
    Springer
    Experimental and applied acarology 24 (2000), S. 283-299 
    Details
    ISSN: 1572-9702
    Keywords: Amblyomma variegatum ; pheromone ; tick ; geographic range ; heartwater
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The tropical bont tick, Amblyomma variegatum, transmits heartwater in sub-Saharan Africa and in the Caribbean. This species has a broad geographic distribution, ranging from Madagascar and other islands in the Indian Ocean through most of sub-Saharan Africa, to several islands in the eastern Caribbean Sea. Blood fed male A. variegatum secrete an attraction–aggregation–attachment (AAA) pheromone which, combined with CO2, excites host finding and formation of feeding clusters of these ticks. However, it is not known whether the composition of the pheromone varies throughout A. variegatum’s geographic range. Extracts of fed male ticks were examined for phenols and volatile organic acids by gas chromatography and mass spectrometry to determine whether differences occur in the pheromone components of populations of this species across the geographic range (Guadeloupe, Zimbabwe, Zambia and Rwanda). No significant difference in the chemical composition of the pheromone in relation to geographic range was found. No significant differences in rates of attachment in response to native versus foreign extracts were found in on-host attachment tests comparing ticks from two countries, Guadeloupe (Caribbean) and Zimbabwe (African). This finding was confirmed in more detailed studies with ticks from Guadeloupe and four African countries (Kenya, Rwanda, Zambia and Zimbabwe). On-host attachment assays from these countries did not detect consistent differences in response to extracts from different locations. In an olfactometer bioassay, females were not consistently more attracted to extracts from their native locality than from any of the foreign localities. We conclude that despite the widespread distribution of A. variegatum over both hemispheres, no significant differences in pheromone composition or biological responses to male tick pheromone secretions occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006479118160
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  • 2
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    Cell migration: integrating signals from front to back (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-06
    Description: Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ridley, Anne J -- Schwartz, Martin A -- Burridge, Keith -- Firtel, Richard A -- Ginsberg, Mark H -- Borisy, Gary -- Parsons, J Thomas -- Horwitz, Alan Rick -- New York, N.Y. -- Science. 2003 Dec 5;302(5651):1704-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14657486" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/physiology ; Animals ; Cell Adhesion ; *Cell Movement ; Cell Polarity ; Humans ; Integrins/physiology ; Models, Biological ; Proteins/metabolism ; Pseudopodia/physiology ; *Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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