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  • Instrumentation and Photography  (7)
  • Humans  (5)
  • 2000-2004  (12)
  • 1
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    Susceptibility locus for Alzheimer's disease on chromosome 10 (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-12-23
    Description: The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Myers, A -- Holmans, P -- Marshall, H -- Kwon, J -- Meyer, D -- Ramic, D -- Shears, S -- Booth, J -- DeVrieze, F W -- Crook, R -- Hamshere, M -- Abraham, R -- Tunstall, N -- Rice, F -- Carty, S -- Lillystone, S -- Kehoe, P -- Rudrasingham, V -- Jones, L -- Lovestone, S -- Perez-Tur, J -- Williams, J -- Owen, M J -- Hardy, J -- Goate, A M -- AG16208/AG/NIA NIH HHS/ -- AG5681/AG/NIA NIH HHS/ -- U24 AG021886/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Dec 22;290(5500):2304-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11125144" target="_blank"〉PubMed〈/a〉
    Keywords: Age of Onset ; Aged ; Alleles ; Alzheimer Disease/*genetics ; Apolipoprotein E4 ; Apolipoproteins E/genetics ; Chromosomes, Human, Pair 10/*genetics ; Genetic Linkage ; Genetic Markers ; *Genetic Predisposition to Disease ; Genotype ; Humans ; Lod Score ; Nuclear Family ; Odds Ratio
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Regional mu opioid receptor regulation of sensory and affective dimensions of pain (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-14
    Description: The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. We examined the function of the opioid system and mu-opioid receptors in the brains of healthy human subjects undergoing sustained pain. Sustained pain induced the regional release of endogenous opioids interacting with mu-opioid receptors in a number of cortical and subcortical brain regions. The activation of the mu-opioid receptor system was associated with reductions in the sensory and affective ratings of the pain experience, with distinct neuroanatomical involvements. These data demonstrate the central role of the mu-opioid receptors and their endogenous ligands in the regulation of sensory and affective components of the pain experience.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zubieta, J K -- Smith, Y R -- Bueller, J A -- Xu, Y -- Kilbourn, M R -- Jewett, D M -- Meyer, C R -- Koeppe, R A -- Stohler, C S -- R01 DE 12059/DE/NIDCR NIH HHS/ -- R01 DE 12743/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 2001 Jul 13;293(5528):311-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Mental Health Research Institute, Medical School, The University of Michigan, Ann Arbor, MI 48104-1687, USA. zubieta@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11452128" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amygdala/physiology ; Analgesics, Opioid/administration & dosage ; Brain/*physiology ; Brain Mapping ; Female ; Fentanyl/administration & dosage/*analogs & derivatives ; Humans ; Magnetic Resonance Imaging ; Male ; Masseter Muscle ; Opioid Peptides/physiology ; *Pain ; Pain Measurement ; Receptors, Opioid, mu/*physiology ; Thalamus/physiology ; Tomography, Emission-Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1 (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-24
    Description: Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX3CR1, an HIV coreceptor and leukocyte chemotactic/adhesion receptor for the chemokine fractalkine. HIV-infected patients homozygous for CX3CR1-I249 M280, a variant haplotype affecting two amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes. Functional CX3CR1 analysis showed that fractalkine binding is reduced among patients homozygous for this particular haplotype. Thus, CX3CR1-I249 M280 is a recessive genetic risk factor in HIV/AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faure, S -- Meyer, L -- Costagliola, D -- Vaneensberghe, C -- Genin, E -- Autran, B -- Delfraissy, J F -- McDermott, D H -- Murphy, P M -- Debre, P -- Theodorou, I -- Combadiere, C -- New York, N.Y. -- Science. 2000 Mar 24;287(5461):2274-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire d'Immunologie Cellulaire et Tissulaire, Centre National de la Recherche Scientifique UMR 7627, Hopital Pitie-Salpetriere, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10731151" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/genetics/*physiopathology/virology ; Case-Control Studies ; Chemokine CX3CL1 ; *Chemokines, CX3C ; Chemokines, CXC/metabolism ; Chromosomes, Human, Pair 3 ; Cohort Studies ; Disease Progression ; European Continental Ancestry Group/genetics ; Genetic Variation ; Genotype ; HIV/physiology ; HIV Infections/genetics/*physiopathology/virology ; Haplotypes ; Homozygote ; Humans ; Leukocytes, Mononuclear/metabolism ; Linkage Disequilibrium ; Membrane Proteins/metabolism ; Mutation ; Polymorphism, Restriction Fragment Length ; *Polymorphism, Single Nucleotide ; Polymorphism, Single-Stranded Conformational ; Receptors, Cytokine/*genetics/*physiology ; Receptors, HIV/*genetics/*physiology ; Survival Analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Calling it something other than cloning (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-07-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer, Eli -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):51-2; author reply 51-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12102093" target="_blank"〉PubMed〈/a〉
    Keywords: *Blastocyst ; *Cloning, Organism/legislation & jurisprudence ; Humans ; *Life ; Semantics ; *Stem Cells ; Terminology as Topic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-29
    Description: Cytokinesis is the essential process that partitions cellular contents into daughter cells. To identify and characterize cytokinesis proteins rapidly, we used a functional proteomic and comparative genomic strategy. Midbodies were isolated from mammalian cells, proteins were identified by multidimensional protein identification technology (MudPIT), and protein function was assessed in Caenorhabditis elegans. Of 172 homologs disrupted by RNA interference, 58% displayed defects in cleavage furrow formation or completion, or germline cytokinesis. Functional dissection of the midbody demonstrated the importance of lipid rafts and vesicle trafficking pathways in cytokinesis, and the utilization of common membrane cytoskeletal components in diverse morphogenetic events in the cleavage furrow, the germline, and neurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679889/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679889/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skop, Ahna R -- Liu, Hongbin -- Yates, John 3rd -- Meyer, Barbara J -- Heald, Rebecca -- F32 GM064159/GM/NIGMS NIH HHS/ -- F32 GM064159-01/GM/NIGMS NIH HHS/ -- F32 GM064159-02/GM/NIGMS NIH HHS/ -- F32 GM064159-03/GM/NIGMS NIH HHS/ -- F32 GM64159-01/GM/NIGMS NIH HHS/ -- P41 RR011823/RR/NCRR NIH HHS/ -- RR1823/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2004 Jul 2;305(5680):61-6. Epub 2004 May 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA. skop@wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166316" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CHO Cells ; Caenorhabditis elegans/cytology/genetics/physiology ; Carrier Proteins/analysis/isolation & purification/physiology ; Cell Cycle/physiology ; *Cell Division ; Cell Fractionation ; Cell Membrane/physiology ; Computational Biology ; Cricetinae ; Cytoskeletal Proteins/analysis/isolation & purification/physiology ; Cytoskeleton/physiology ; Germ Cells/physiology ; HeLa Cells ; Humans ; Membrane Microdomains/physiology ; Morphogenesis ; Organelles/chemistry/*physiology ; Protein Transport ; Proteins/analysis/isolation & purification/*physiology ; Proteome/*analysis ; Proteomics ; Signal Transduction ; Spindle Apparatus/physiology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    The Long Duration Flight of the TopHat Experiment (2002)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: TopHat is a balloon-borne instrument designed to operate on the top of a balloon. From this location, the experiment could efficiently observe using a clean beam with extremely low sidelobes. The experiment was designed to scan a large portion of the sky directly above it and to map the anisotropy of the Cosmic Microwave Background (CMBR) and thermal emission from galactic dust. The instrument used a one meter class telescope with a five band single pixel radiometer spanning the frequency range from 150-600 GHz. The radiometer used bolometric detectors operating at approx. 250 mK. Here, we will report on the flight of the TopHat experiment over Antarctica in January, 2001 and describe the scientific goals, the operation, and in-flight performance.
    Keywords: Instrumentation and Photography
    Type: SPIE Meeting; Aug 22, 2002 - Aug 28, 2002; Waikoloa, HI; United States
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
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    SOFIA First Generation Science Instruments (2003)
    In:  Other Sources
    Details
    Publication Date: 2019-07-18
    Description: SOFIA will provide 0.3- 1600 pm wavelength coverage, excellent FIR/submm angular resolution, a variety of focal plane instruments, and access to them throughout a 20-year lifetime. These attributes assure SOFIA a vital role in future observations of the interstellar medium, and in numerous other studies. SOFIA is a joint program of NASA in the U.S. and DLR in Germany. Observing time will be arranged by annual peer review of proposals, with roughly 80 percent of the time granted by the U.S. and 20 percent of the time granted by Germany. International proposals may be submitted to either time allocation committee. SOFIA is expected to begin science flights in 2005.
    Keywords: Instrumentation and Photography
    Type: Dense Interstellar Medium in Galaxies; Sep 22, 2003 - Sep 26, 2003; Zermatt; Switzerland
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    NASA TECHNICAL REPORTS
  • 8
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    Video Image Stabilization and Registration (2002)
    In:  CASI
    Details
    Publication Date: 2019-07-10
    Description: A method of stabilizing and registering a video image in multiple video fields of a video sequence provides accurate determination of the image change in magnification, rotation and translation between video fields, so that the video fields may be accurately corrected for these changes in the image in the video sequence. In a described embodiment, a key area of a key video field is selected which contains an image which it is desired to stabilize in a video sequence. The key area is subdivided into nested pixel blocks and the translation of each of the pixel blocks from the key video field to a new video field is determined as a precursor to determining change in magnification, rotation and translation of the image from the key video field to the new video field.
    Keywords: Instrumentation and Photography
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  • 9
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    Video Image Stabilization and Registration (2003)
    In:  CASI
    Details
    Publication Date: 2019-08-13
    Description: A method of stabilizing and registering a video image in multiple video fields of a video sequence provides accurate determination of the image change in magnification, rotation and translation between video fields, so that the video fields may be accurately corrected for these changes in the image in the video sequence. In a described embodiment, a key area of a key video field is selected which contains an image which it is desired to stabilize in a video sequence. The key area is subdivided into nested pixel blocks and the translation of each of the pixel blocks from the key video field to a new video field is determined as a precursor to determining change in magnification, rotation and translation of the image from the key video field to the new video field.
    Keywords: Instrumentation and Photography
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    NASA TECHNICAL REPORTS
  • 10
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    SOFIA Water Vapor Monitor Design (2002)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The SOFIA Water Vapor Monitor (WVM) is a heterodyne radiometer designed to determine the integrated amount of water vapor along the telescope line of sight and directly to the zenith. The basic technique that was chosen for the WVM uses radiometric measurements of the center and wings of the 183.3 GHz rotational line of water to measure the water vapor. The WVM reports its measured water vapor levels to the aircraft Mission Controls and Communication System (MCCS) while the SOFIA observatory is in normal operation at flight altitude. The water vapor measurements are also available to other scientific instruments aboard the observatory. The electrical, mechanical and software design of the WVM are discussed.
    Keywords: Instrumentation and Photography
    Type: Astronomical Telescopes and Instrumentation; Aug 01, 2002; Waikoloa, HI; United States
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