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  • 1
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    Fish population persistence in hydrologically variable landscapes (2014)
    Wiley
    Details
    Publication Date: 2014-12-21
    Description: Forecasting population persistence in environments subjected to periodic disturbances represents a general challenge for ecologists. In arid and semi-arid regions, climate change and human water use represent significant threats to the future persistence of aquatic biota whose populations typically depend on permanent refuge waterholes for their viability, as such habitats are increasingly being lost as a result of decreasing runoff and increased water extraction. We constructed a spatially explicit population model for golden perch Macquaria ambigua (Richardson), a native freshwater fish in the Murray-Darling Basin, eastern Australia. We then used the model to examine the effects of increased aridity, increased drought frequency, and localized human water extraction on population viability. Consistent with current observations, the model predicted golden perch population persistence under the current climate and levels of water use. Modeled increases in local water extraction greatly increased the risk of population decline, while scenarios of increased aridity and drought frequency were associated with only minor increase in this risk. We conclude that natural variability in abundances and high turnover rates (extinction / recolonization) of local populations dictate the importance of spatial connectivity and periodic cycles of population growth. Our study also demonstrates an effective way to examine population persistence in intermittent and ephemeral river systems by integrating spatial and temporal dynamics of waterhole persistence with demographic processes (survival, recruitment and dispersal) within a stochastic modeling framework. The approach can be used to help understand the impacts of natural and anthropogenic drivers, including water resource development, on the viability of biota inhabiting highly dynamic environments. # doi:10.1890/14-1618.1
    Print ISSN: 1051-0761
    Electronic ISSN: 1939-5582
    Topics: Biology
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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  • 2
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    Susceptibility locus for Alzheimer's disease on chromosome 10 (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-12-23
    Description: The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Myers, A -- Holmans, P -- Marshall, H -- Kwon, J -- Meyer, D -- Ramic, D -- Shears, S -- Booth, J -- DeVrieze, F W -- Crook, R -- Hamshere, M -- Abraham, R -- Tunstall, N -- Rice, F -- Carty, S -- Lillystone, S -- Kehoe, P -- Rudrasingham, V -- Jones, L -- Lovestone, S -- Perez-Tur, J -- Williams, J -- Owen, M J -- Hardy, J -- Goate, A M -- AG16208/AG/NIA NIH HHS/ -- AG5681/AG/NIA NIH HHS/ -- U24 AG021886/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Dec 22;290(5500):2304-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11125144" target="_blank"〉PubMed〈/a〉
    Keywords: Age of Onset ; Aged ; Alleles ; Alzheimer Disease/*genetics ; Apolipoprotein E4 ; Apolipoproteins E/genetics ; Chromosomes, Human, Pair 10/*genetics ; Genetic Linkage ; Genetic Markers ; *Genetic Predisposition to Disease ; Genotype ; Humans ; Lod Score ; Nuclear Family ; Odds Ratio
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Conductance quantization at a half-integer plateau in a symmetric GaAs quantum wire (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-06-03
    Description: We present data from an induced gallium arsenide (GaAs) quantum wire that exhibits an additional conductance plateau at 0.5(2e2/h), where e is the charge of an electron and h is Planck's constant, in zero magnetic field. The plateau was most pronounced when the potential landscape was tuned to be symmetric by using low-temperature scanning-probe techniques. Source-drain energy spectroscopy and temperature response support the hypothesis that the origin of the plateau is the spontaneous spin-polarization of the transport electrons: a ferromagnetic phase. Such devices may have applications in the field of spintronics to either generate or detect a spin-polarized current without the complications associated with external magnetic fields or magnetic materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crook, R -- Prance, J -- Thomas, K J -- Chorley, S J -- Farrer, I -- Ritchie, D A -- Pepper, M -- Smith, C G -- New York, N.Y. -- Science. 2006 Jun 2;312(5778):1359-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cavendish Laboratory, 19 JJ Thomson Avenue, Cambridge CB3 0HE, UK. rc230@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16741116" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Determing Rubber Hydrocarbon in Rubber-Bearing Plants (1953)
    s.l. : American Chemical Society
    Analytical chemistry 25 (1953), S. 1535-1538 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60082a033
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  • 5
    Electronic Resource
    Electronic Resource
    ApoE2 Allele, Down's Syndrome, and Dementia (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 777 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: All individuals with Down's syndrome (trisomy 21-DS) develop the pathogenic hallmarks of Alzheimer's disease in old age (+40 years).1-4 The extent of pathology is variable, but it has been shown that the amount of β-amyloid pathology is variable and related to age and the degree of dementia.3 Thus, in DS, growing old is associated with a progressive pathological process which results in cognitive decline. However, neuropsychological studies of older DS subjects have identified a clinical dementia in only a proportion of cases.1-4These contradictory observations could be reconciled if some factor existed which modulated the rate and amount of β-amyloid pathology. Recent studies demonstrate an association between the apolipoprotein E4 (ApoE4) allele and the earlier age of onset in both sporadic8-9 and familial10 AD. Increased amounts of βamyloid pathology can also be related to the E4 allele. However, at present there are no data documenting the effects of ApoE genotype on the expression or degree of clinical symptoms of the disease. We have examined the ApoE genotype in a cohort of clinically evaluated elderly patients with DS in order to examine the effects of ApoE genotype on the clinical symptoms of dementia. We report here that, despite the presence of an active disease process, the ApoE E2 allele is associated with longevity and preservation of cognitive functioning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb34428.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of palm oil, margarine, butter, and sunflower oil on the serum lipids and lipoproteins of normocholesterolemic middle-aged men
    Amsterdam : Elsevier
    Journal of Nutritional Biochemistry 4 (1993), S. 286-297 
    Details
    ISSN: 0955-2863
    Keywords: apolipoproteins ; cholesterol ; dietary fats ; lipoproteins ; palm oil ; trans fatty acids ; triglycerides
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0955-2863(93)90099-I
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  • 7
    Electronic Resource
    Electronic Resource
    The structure of the presenilin 1 ( S182 ) gene and identification of six novel mutations in early onset AD families (1995)
    [s.l.] : Nature Publishing Group
    Nature genetics 11 (1995), S. 219-222 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We isolated full length cDNA clones for the PS-1 gene. Analysis of the sequence of this clone revealed that it was identical in predicted amino acid sequence to that previously reported5 with the exception of the absence of amino acids VRSQ at position 26-29. Comparison of this sequence in Genbank ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1095-219
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  • 8
    Electronic Resource
    Electronic Resource
    Damage and the nonlinear viscoelastic response of glassy polycarbonate and LaRC-TPI (1993)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 33 (1993), S. 56-62 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: In the bulk, the nonlinear viscoelastic response of glassy polymers is due to the irreversible work done on the body by the surroundings. The source of the irreversibility is plastic flow of material near distributed shear bands or microcracks in the polymer. Shear bands and microcracks also form new traction free boundaries in the body. The presence of these new boundaries diminish the load bearing capacity of the polymer. These changes in polymer lattice structure are a mechanism that promotes the release of stored strain energy. If the release of stored strain energy is stress controlled, then at sufficiently high levels of stress to cause a permanent structural arrangement of the polymer chains, polycarbonate and LaRC-TPI behave as nonlinear viscoelastic materials. If the current stress is less than the maximum stress the polymer has experienced, then the current energy release rate for the propagation of shear bands, crazes, etc., is less than the critical energy release rate. In this instance, damage production is a constant and the material can be modeled using linear viscoelasticity. It will be shown that the stress-induced nonlinear shift factors are a measure of the rate of damage production in glassy polycarbonate.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760330107
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  • 9
    Electronic Resource
    Electronic Resource
    Free volume in glassy poly(arylene ether ketone)s (1992)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 30 (1992), S. 1195-1198 
    Details
    ISSN: 0887-6266
    Keywords: free volume in glassy poly(arylene ether ketones)s ; glassy polymers, free volume in ; poly(arylene ether ketone)s, free volume in ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Amorphous polyarylene ether ketones were examined in the glassy state by positron annihilation lifetime spectroscopy (PALS) and in the melt by standard rheological techniques. Specimens were well-characterized fractions of two isomeric structures. PALS clearly shows that the polymer with meta linkages in its backbone contains larger voids (〉 0.25 nm radius). Thus despite their similar bulk densities, the two materials must pack very differently on a local scale. On the other hand, the free volumes inferred from the WLF treatment of melt viscosity data are practically identical in both materials ca. 4% at Tg. The comparison between techniques sheds some light on the distribution of free volume. © 1992 John Wiley & Sons, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1992.090301103
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  • 10
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    Imaging Fractal Conductance Fluctuations and Scarred Wave Functions in a Quantum Billiard (2003)
    American Physical Society
    Details
    Publication Date: 2003-12-11
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society
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