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  • 1
    Keywords: climate change ; agriculture
    Description / Table of Contents: The Agricultural Model Intercomparison and Improvement Project: Phase I Activities by a Global Community of Science (Cynthia Rosenzweig, James W Jones, Jerry L Hatfield, John M Antle, Alexander C Ruane, and Carolyn Z Mutter) --- AgMIP's Transdisciplinary Agricultural Systems Approach to Regional Integrated Assessment of Climate Impacts, Vulnerability, and Adaptation (John M Antle, Roberto O Valdivia, Kenneth J Boote, Sander Janssen, James W Jones, Cheryl H Porter, Cynthia Rosenzweig, Alexander C Ruane, and Peter J Thorburn) --- AgMIP Climate Data and Scenarios for Integrated Assessment (Alexander C Ruane, Jonathan M Winter, Sonali P McDermid, and Nicholas I Hudson) --- Cropping Systems Modeling in AgMIP: A New Protocol-Driven Approach for Regional Integrated Assessments (Peter J Thorburn, Kenneth J Boote, John N G Hargreaves, Perry L Poulton, and James W Jones) --- Representative Agricultural Pathways and Scenarios for Regional Integrated Assessment of Climate Change Impacts, Vulnerability, and Adaptation (Roberto O Valdivia, John M Antle, Cynthia Rosenzweig, Alexander C Ruane, Joost Vervoort, Muhammad Ashfaq, Ibrahima Hathie, Sabine Homann-Kee Tui, Richard Mulwa, Charles Nhemachena, Paramasivam Ponnusamy, Herath Rasnayaka, and Harbir Singh) --- Data Interoperability Tools for Regional Integrated Assessments (Cheryl H Porter, Chris Villalobos, Dean Holzworth, Roger Nelson, Jefffrey W White, Ioannis N Athanasiadis, Meng Zhang, Sander Janssen, Rob Knapen, James W Jones, Kenneth J Boote, John Hargreaves, and John M Antle) --- The AgMIP GRIDded Crop Modeling Initiative (AgGRID) and the Global Gridded Crop Model Intercomparison (GGCMI) (Joshua Elliott and Christoph Müller) --- The AgMIP Coordinated Climate-Crop Modeling Project (C3MP): Methods and Protocols (Sonali P McDermid, Alexander C Ruane, Cynthia Rosenzweig, Nicholas I Hudson, Monica D Morales, Prabodha Agalawatte, Shakeel Ahmad, L R Ahuja, Istiqlal Amien, Saseendran S Anapalli, Jakarat Anothai, Senthold Asseng, Jody Biggs, Federico Bert, Patrick Bertuzzi, Virender S Bhatia, Marco Bindi, Ian Broad, Davide Cammarano, Ramiro Carretero, Ashfaq Ahmad Chattha, Uran Chung, Stephanie Debats, Paola Deligios, Giacomo De Sanctis, Thanda Dhliwayo, Benjamin Dumont, Lyndon Estes, Frank Ewert, Roberto Ferrise, Thomas Gaiser, Guillermo Garcia, Sika Gbegbelegbe, Vellingiri Geethalakshmi, Edward Gerardeaux, Richard Goldberg, Brian Grant, Edgardo Guevara, Jonathan Hickman, Holger Hoffmann, Huanping Huang, Jamshad Hussain, Flavio Barbosa Justino, Asha S Karunaratne, Ann-Kristin Koehler, Patrice K Kouakou, Soora Naresh Kumar, Arunachalam Lakshmanan, Mark Lieffering, Xiaomao Lin, Qunying Luo, Graciela Magrin, Marco Mancini, Fabio Ricardo Marin, Anna Dalla Marta, Yuji Masutomi, Theodoros Mavromatis, Greg McLean, Santiago Meira, Monoranjan Mohanty, Marco Moriondo, Wajid Nasim, Lamyaa Negm, Francesca Orlando, Simone Orlandini, Isik Ozturk, Helena Maria Soares Pinto, Guillermo Podesta, Zhiming Qi, Johanna Ramarohetra, Muhammad Habib ur Rahman, Helene Raynal, Gabriel Rodriguez, Reimund Rötter, Vaishali Sharda, Lu Shuo, Ward Smith, Val Snow, Afshin Soltani, K Srinivas, Benjamin Sultan, Dillip Kumar Swain, Fulu Tao, Kindie Tesfaye, Maria I Travasso, Giacomo Trombi, Alex Topaj, Eline Vanuytrecht, Federico E Viscarra, Syed Aftab Wajid, Enli Wang, Hong Wang, Jing Wang, Erandika Wijekoon, Lee Byun-Woo, Yang Xiaoguang, Ban Ho Young, Jin I Yun, Zhigan Zhao, and Lareef Zubair) --- Uncertainty in Agricultural Impact Assessment (Daniel Wallach, Linda O Mearns, Michael Rivington, John M Antle, and Alexander C Ruane) --- Uncertainties in Scaling-Up Crop Models for Large-Area Climate Change Impact Assessments (Frank Ewert, Lenny G J van Bussel, Gang Zhao, Holger Hoffmann, Thomas Gaiser, Xenia Specka, Claas Nendel, Kurt-Christian Kersebaum, Carmen Sosa, Elisabet Lewan, Jagadeesh Yeluripati, Matthias Kuhnert, Fulu Tao, Reimund Rötter, Julie Constantin, Helene Raynal, Daniel Wallach, Edmar Teixeira, Balasz Grosz, Michaela Bach, Luca Doro, Pier Paolo Roggero, Zhigan Zhao, Enli Wang, Ralf Kiese, Edwin Haas, Henrik Eckersten, Giacomo Trombi, Marco Bindi, Christian Klein, Christian Biernath, Florian Heinlein, Eckart Priesack, Davide Cammarano, Senthold Asseng, Joshua Elliott, Michael Glotter, Bruno Basso, Guillermo A Baigorria, Consuelo C Romero, and Marco Moriondo) --- Statistical Analysis of Large Simulated Yield Datasets for Studying Climate Change Effects (David Makowski, Senthold Asseng, Frank Ewert, Simona Bassu, Jean-Louis Durand, Pierre Martre, Myriam Adam, Pramod K Aggarwal, Carlos Angulo, Christian Baron, Bruno Basso, Patrick Bertuzzi, Christian Biernath, Hendrik Boogaard, Kenneth J Boote, Nadine Brisson, Davide Cammarano, Andrew J Challinor, Sjakk J G Conijn, Marc Corbeels, Delphine Deryng, Giacomo De Sanctis, Jordi Doltra, Sebastian Gayler, Richard Goldberg, Patricio Grassini, Jerry L Hatfield, Lee Heng, Steven Hoek, Josh Hooker, Tony L A Hunt, Joachim Ingwersen, Cesar Izaurralde, Raymond E E Jongschaap, James W Jones, Armen R Kemanian, Christian Kersebaum, Soo-Hyung Kim, Jon Lizaso, Christoph Müller, Naresh S Kumar, Claas Nendel, Garry J O'Leary, Jorgen E Olesen, Tom M Osborne, Taru Palosuo, Maria V Pravia, Eckart Priesack, Dominique Ripoche, Cynthia Rosenzweig, Alexander C Ruane, Fredirico Sau, Mickhail A Semenov, Iurii Shcherbak, Pasquale Steduto, Claudio Stöckle, Pierre Stratonovitch, Thilo Streck, Iwan Supit, Fulu Tao, Edmar I Teixeira, Peter Thorburn, Denis Timlin, Maria Travasso, Reimund Rötter, Katharina Waha, Daniel Wallach, Jeffrey W White, Jimmy R Williams, and Joost Wolf) --- Crop Diseases and Climate Change in the AgMIP Framework (Ariena H C van Bruggen, James W Jones, Jose Mauricio C Fernandes, Karen Garrett, and Kenneth J Boote) --- Perspectives on Climate Effects on Agriculture: The International Efforts of AgMIP in Sub-Saharan Africa (Job Kihara, Dilys S MacCarthy, Andre Bationo, Saidou Koala, Jonathan Hickman, Jawoo Koo, Charles Vanya, Samuel Adiku, Yacob Beletse, Patricia Masikate, Karuturi P C Rao, Carolyn Z Mutter, Cynthia Rosenzweig, and James W Jones) --- Climate Change Impacts on West African Agriculture: An Integrated Regional Assessment (CIWARA) (Samuel G K Adiku, Dilys S MacCarthy, Ibrahima Hathie, Madina Diancoumba, Bright S Freduah, Joseph Amikuzuno, P C Sibiry Traore, Seydou Traore, Eric Koomson, Alhassane Agali, Jon I Lizaso, Dougbedji Fatondji, Myriam Adams, Lodoun Tigana, Daouda Z Diarra, Ousmane N'diaye, and Roberto O Valdivia) --- Impacts of Climate Variability and Change on Agricultural Systems in East Africa (Karuturi P C Rao, Gummadi Sridhar, Richard M Mulwa, Mary N Kilavi, Anthony Esilaba, Ioannis N Athanasiadis, and Roberto O Valdivia) --- Projected Impacts of Climate Change Scenarios on the Production of Maize in Southern Africa: An Integrated Assessment Case Study of the Bethlehem District, Central Free State, South Africa (Yacob G Beletse, Wiltrud Durand, Charles Nhemachena, Olivier Crespo, Weldemichael A Tesfuhuney, Matthew R Jones, Mogos Y Teweldemedhin, Sunshine M Gamedze, Pontsho M Bonolo, Syanda Jonas, SueWalker, Patrick Gwimbi, Thembeka N Mpuisang, Davide Cammarano, and Roberto O Valdivia) --- Crop-Livestock Intensification in the Face of Climate Change: Exploring Opportunities to Reduce Risk and Increase Resilience in Southern Africa by Using an Integrated Multi-modeling Approach (Patricia Masikati, Sabine Homann-Kee Tui, Katrien Descheemaeker, Olivier Crespo, Sue Walker, Christopher J Lennard, Lieven Claessens, Arthur C Gama, Sebastiao Famba, Andre F van Rooyen, and Roberto O Valdivia) --- Integrated Assessments of the Impacts of Climate Change on Agriculture: An Overview of AgMIP Regional Research in South Asia (Sonali P McDermid, Guntuku Dileepkumar, K M Dakshina Murthy, S Nedumaran, Piara Singh, Chukka Srinivasa, B Gangwar, N Subash, Ashfaq Ahmad, Lareef Zubair, and S P Nissanka) --- Impact of Climate Change on the Rice–Wheat Cropping System of Pakistan (Ashfaq Ahmad, Muhammad Ashfaq, Ghulam Rasul, Syed Aftab Wajid, Tasneem Khaliq, Fahd Rasul, Umer Saeed, Muhammad Habib ur Rahman, Jamshad Hussain, Irfan Ahmad Baig, Syed Asif Ali Naqvi, Syed Ahsan Ali Bokhari, Shakeel Ahmad, Wajid Naseem, Gerrit Hoogenboom, and Roberto O Valdivia) --- Integrated Climate Change Assessment through Linking Crop Simulation with Economic Modeling — Results from the Indo-Gangetic Basin (Nataraja Subash, Babooji Gangwar, Harbir Singh, Guillermo Baigorria, Alok Kumar Sikka, and Roberto O Valdivia) --- Integrated Assessment of Climate Change Impacts on Maize Farms and Farm Household Incomes in South India: A Case Study from Tamil Nadu (Paramasivam Ponnusamy, Geethalakshmi Vellingiri, Raji Reddy Danda, Lakshmanan Arunachalam, Dakshina Murthy, Sunandini Prema, Sreenivas Gade, Sonali P McDermid, and Roberto O Valdivia) --- Climate Change Impacts on Rice Farming Systems in Northwestern Sri Lanka (Lareef Zubair, Sarath P Nissanka, W M W Weerakoon, Dumindu I Herath, Asha S Karunaratne, A S M Prabodha, M B Agalawatte, Rasnayaka M Herath, S Zeenas Yahiya, B V R Punyawardene, Janan Vishwanathan, Punya Delpitiya, A Erandika N Wijekoon, Janaka Gunaratna, Sewwandhi S K Chandrasekara, P Wickramagamage, K D N Weerasinghe, Champa M Navaratne, Ruchika S Perera, Asela I Gunesekara, G M Pradeep Kumara, Daniel Wallach, Roberto O Valdivia, and Sonali P McDermid) --- AgMIP Regional Activities in a Global Framework: The Brazil Experience (Eduardo D Assad, Fábio R Marin, Roberto O Valdivia, and Cynthia Rosenzweig) --- AgMIP Regional Activities in a Global Framework: The China Experience (Fulu Tao and Erda Lin) --- AgMIP Training in Multiple Crop Models and Tools (Kenneth J Boote, Cheryl H Porter, John Hargreaves, Gerrit Hoogenboom, Peter Thorburn, and Carolyn Mutter) --- Major Findings and Future Activities (Cynthia Rosenzweig and Daniel Hillel)
    Pages: Online-Ressource (XXVII, 525 pages (part 1); XXIII, 580 pages (part 2))
    ISBN: 9781783265633
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 219-232 
    ISSN: 1573-1596
    Keywords: climate change ; mediterranean region ; agriculture ; cereal production ; impact assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract Current trends in Mediterranean agriculture reveal differences between the Northern and Southern Mediterranean countries as related to population growth, land and water use, and food supply and demand. The changes in temperature and precipitation predicted by general circulation models for the Mediterranean region will affect water availability and resource management, critically shaping the patterns of future crop production. Three companion papers analyze in detail future impacts of predicted climate change on wheat (Triticum aestivum L.) and maize (Zea mays L.) production in Spain, Greece, and Egypt, and test farm- level adaptation strategies such as early planting and cultivar change with the aid of dynamic crop models. Strategies to improve the assessment of the potential effects of future climate change on agricultural production are discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 233-250 
    ISSN: 1573-1596
    Keywords: climate change ; vulnerability ; adaptation ; agriculture ; Egypt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract If no timely measures are taken to adapt Egyptian agriculture to possible climate warming, the effects may be negative and serious. Egypt appears to be particularly vulnerable to climate change because of its dependence on the Nile River as the primary water source, its large traditional agricultural base, and its long coastline, already undergoing both intensifying development and erosion. A simulation study characterized potential yield and water use efficiency decreases on two reference crops in the main agricultural regions with possible future climatic variation, even when the beneficial effects of increased CO2 were taken into account. On-farm adaptation techniques which imply no additional cost to the agricultural system, did not compensate for the yield losses with the warmer climate or improve the crop water-use efficiency. Economic adjustments such as the improvement of the overall water-use efficiency of the agricultural system, soil drainage and conservation, land management, and crop alternatives are essential. If appropriate measures are taken, negative effects of climate change in agricultural production and other major resource sectors (water and land) may be lessened.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 219-232 
    ISSN: 1573-1596
    Keywords: climate change ; mediterranean region ; agriculture ; cereal production ; impact assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract Current trends in Mediterranean agriculture reveal differences between the Northern and Southern Mediterranean countries as related to population growth, land and water use, and food supply and demand. The changes in temperature and precipitation predicted by general circulation models for the Mediterranean region will affect water availability and resource management, critically shaping the patterns of future crop production. Three companion papers analyze in detail future impacts of predicted climate change on wheat (Triticum aestivum L.) and maize (Zea mays L.) production in Spain, Greece, and Egypt, and test farm- level adaptation strategies such as early planting and cultivar change with the aid of dynamic crop models. Strategies to improve the assessment of the potential effects of future climate change on agricultural production are discussed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Mitigation and adaptation strategies for global change 1 (1997), S. 233-250 
    ISSN: 1573-1596
    Keywords: climate change ; vulnerability ; adaption ; agriculture ; Egypt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Abstract If no timely measures are taken to adapt Egyptian agriculture to possible climate warming, the effects may be negative and serious. Egypt appears to be particularly vulnerable to climate change because of its dependence on the Nile River as the primary water source, its large traditional agricultural base, and its long coastline, already undergoing both intensifying development and erosion. A simulation study characterized potential yield and water use efficiency decreases on two reference crops in the main agricultural regions with possible future climatic variation, even when the beneficial effects of increased CO2 were taken into account. On-farm adaptation techniques which imply no additional cost to the agricultural system, did not compensate for the yield losses with the warmer climate or improve the crop water-use efficiency. Economic adjustments such as the improvement of the overall water-use efficiency of the agricultural system, soil drainage and conservation, land management, and crop alternatives are essential. If appropriate measures are taken, negative effects of climate change in agricultural production and other major resource sectors (water and land) may be lessened.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Environmental modeling and assessment 4 (1999), S. 115-132 
    ISSN: 1573-2967
    Keywords: agriculture ; land use ; wheat production ; simulation models ; China
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract CERES-Wheat, a dynamic process crop growth model, is specified and validated for eight sites in the major wheat-growing regions of China. Crop model results are then used to test the Mitscherlich-Baule and the quadratic functional forms for yield response to nitrogen fertilizer, irrigation water, temperature, and precipitation. The resulting functions are designed to be used in a linked biophysical-economic model of land-use and land-cover change in China. While both functions predict yield responses adequately, the Mitscherlich-Baule function is preferable to the quadratic function because its parameters are biologically and physically realistic. Variables explaining a significant proportion of simulated yield variance are nitrogen, irrigation water, and precipitation; temperature was a less significant component of yield variation within the range of observed year-to-year variability at the study sites. Crop model simulations with a generic soil with median characteristics of the eight sites compared to simulations with site-specific soils showed that agricultural soils in China have similar and, in general, low-to-moderate water-holding capacities and organic matter contents. The validated crop model is useful for simulating the range of conditions under which wheat is grown in China, and provides the means to estimate production functions when experimental field data are not available.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2001-07-14
    Description: Interferons (IFN) alpha/beta and gamma induce the formation of two transcriptional activators: gamma-activating factor (GAF) and interferon-stimulated gamma factor 3 (ISGF3). We report a natural heterozygous germline STAT1 mutation associated with susceptibility to mycobacterial but not viral disease. This mutation causes a loss of GAF and ISGF3 activation but is dominant for one cellular phenotype and recessive for the other. It impairs the nuclear accumulation of GAF but not of ISGF3 in heterozygous cells stimulated by IFNs. Thus, the antimycobacterial, but not the antiviral, effects of human IFNs are principally mediated by GAF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dupuis, S -- Dargemont, C -- Fieschi, C -- Thomassin, N -- Rosenzweig, S -- Harris, J -- Holland, S M -- Schreiber, R D -- Casanova, J L -- New York, N.Y. -- Science. 2001 Jul 13;293(5528):300-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire de Genetique Humaine des Maladies Infectieuses, Universite de Paris Rene Descartes-INSERM UMR550, Faculte de Medecine Necker-Enfants Malades, 75015 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11452125" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Cell Line ; Child ; Child, Preschool ; DNA/metabolism ; DNA-Binding Proteins/genetics/*physiology ; Female ; Fibroblasts/metabolism/virology ; Gene Expression Regulation ; *Germ-Line Mutation ; Humans ; *Immunity/genetics ; Interferon-Stimulated Gene Factor 3 ; Interferon-Stimulated Gene Factor 3, gamma Subunit ; Interferon-alpha/*immunology/metabolism ; Interferon-gamma/*immunology/metabolism ; Janus Kinase 1 ; Mice ; Mycobacterium Infections/genetics/*immunology ; Mycobacterium avium Complex/immunology ; Mycobacterium avium-intracellulare Infection/genetics/immunology ; Mycobacterium bovis ; Pedigree ; Protein Binding ; Protein-Tyrosine Kinases/genetics ; STAT1 Transcription Factor ; Signal Transduction ; Simian virus 40 ; Trans-Activators/genetics/*physiology ; Transcription Factors/physiology ; Virus Diseases/genetics/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 1998-05-09
    Description: Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4+ T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4+ T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD4+ T cell loss in early SIV infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Veazey, R S -- DeMaria, M -- Chalifoux, L V -- Shvetz, D E -- Pauley, D R -- Knight, H L -- Rosenzweig, M -- Johnson, R P -- Desrosiers, R C -- Lackner, A A -- AI25328/AI/NIAID NIH HHS/ -- AI38559/AI/NIAID NIH HHS/ -- DK50550/DK/NIDDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1998 Apr 17;280(5362):427-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Post Office Box 9102, Southborough, MA 01772, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9545219" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/*immunology/virology ; Colon/*immunology/virology ; Immunity, Mucosal ; Immunologic Memory ; Intestinal Mucosa/immunology/virology ; Intestine, Small/*immunology/virology ; Lymphocyte Activation ; Lymphocytes/immunology/virology ; Lymphoid Tissue/immunology/virology ; Macaca mulatta ; Macrophages/virology ; Male ; Receptors, Interleukin-2/analysis ; Simian Acquired Immunodeficiency Syndrome/*immunology/*virology ; Simian Immunodeficiency Virus/immunology/pathogenicity/*physiology ; Viral Load ; Virulence ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2008-06-13
    Description: Animals from flies to humans are able to distinguish subtle gradations in temperature and show strong temperature preferences. Animals move to environments of optimal temperature and some manipulate the temperature of their surroundings, as humans do using clothing and shelter. Despite the ubiquitous influence of environmental temperature on animal behaviour, the neural circuits and strategies through which animals select a preferred temperature remain largely unknown. Here we identify a small set of warmth-activated anterior cell (AC) neurons located in the Drosophila brain, the function of which is critical for preferred temperature selection. AC neuron activation occurs just above the fly's preferred temperature and depends on dTrpA1, an ion channel that functions as a molecular sensor of warmth. Flies that selectively express dTrpA1 in the AC neurons select normal temperatures, whereas flies in which dTrpA1 function is reduced or eliminated choose warmer temperatures. This internal warmth-sensing pathway promotes avoidance of slightly elevated temperatures and acts together with a distinct pathway for cold avoidance to set the fly's preferred temperature. Thus, flies select a preferred temperature by using a thermal sensing pathway tuned to trigger avoidance of temperatures that deviate even slightly from the preferred temperature. This provides a potentially general strategy for robustly selecting a narrow temperature range optimal for survival.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730888/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730888/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamada, Fumika N -- Rosenzweig, Mark -- Kang, Kyeongjin -- Pulver, Stefan R -- Ghezzi, Alfredo -- Jegla, Timothy J -- Garrity, Paul A -- P01 NS044232/NS/NINDS NIH HHS/ -- P01 NS044232-060002/NS/NINDS NIH HHS/ -- P01 NS044232-070002/NS/NINDS NIH HHS/ -- P30 NS045713/NS/NINDS NIH HHS/ -- P30 NS045713-069006/NS/NINDS NIH HHS/ -- P30 NS045713S10/NS/NINDS NIH HHS/ -- R01 EY013874/EY/NEI NIH HHS/ -- R01 EY013874-06/EY/NEI NIH HHS/ -- R01 EY13874/EY/NEI NIH HHS/ -- R01 MH067284/MH/NIMH NIH HHS/ -- R01 MH067284-05/MH/NIMH NIH HHS/ -- RR16780/RR/NCRR NIH HHS/ -- England -- Nature. 2008 Jul 10;454(7201):217-20. doi: 10.1038/nature07001. Epub 2008 Jun 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Center for Behavioral Genomics, Volen Center for Complex Systems, Biology Department, Brandeis University MS-008, 415 South Street, Waltham, Massachusetts 02454, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18548007" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning ; Body Temperature ; Choice Behavior/*physiology ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster/growth & development/*physiology ; Female ; Larva ; Molecular Sequence Data ; Neurons/metabolism ; Oocytes/metabolism ; TRPC Cation Channels/genetics/*metabolism ; *Temperature ; Xenopus laevis
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2008-02-22
    Description: Ischaemia of the heart, brain and limbs is a leading cause of morbidity and mortality worldwide. Hypoxia stimulates the secretion of vascular endothelial growth factor (VEGF) and other angiogenic factors, leading to neovascularization and protection against ischaemic injury. Here we show that the transcriptional coactivator PGC-1alpha (peroxisome-proliferator-activated receptor-gamma coactivator-1alpha), a potent metabolic sensor and regulator, is induced by a lack of nutrients and oxygen, and PGC-1alpha powerfully regulates VEGF expression and angiogenesis in cultured muscle cells and skeletal muscle in vivo. PGC-1alpha-/- mice show a striking failure to reconstitute blood flow in a normal manner to the limb after an ischaemic insult, whereas transgenic expression of PGC-1alpha in skeletal muscle is protective. Surprisingly, the induction of VEGF by PGC-1alpha does not involve the canonical hypoxia response pathway and hypoxia inducible factor (HIF). Instead, PGC-1alpha coactivates the orphan nuclear receptor ERR-alpha (oestrogen-related receptor-alpha) on conserved binding sites found in the promoter and in a cluster within the first intron of the VEGF gene. Thus, PGC-1alpha and ERR-alpha, major regulators of mitochondrial function in response to exercise and other stimuli, also control a novel angiogenic pathway that delivers needed oxygen and substrates. PGC-1alpha may provide a novel therapeutic target for treating ischaemic diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arany, Zoltan -- Foo, Shi-Yin -- Ma, Yanhong -- Ruas, Jorge L -- Bommi-Reddy, Archana -- Girnun, Geoffrey -- Cooper, Marcus -- Laznik, Dina -- Chinsomboon, Jessica -- Rangwala, Shamina M -- Baek, Kwan Hyuck -- Rosenzweig, Anthony -- Spiegelman, Bruce M -- P30 DK040561/DK/NIDDK NIH HHS/ -- P30 DK040561-12/DK/NIDDK NIH HHS/ -- R01 DK054477/DK/NIDDK NIH HHS/ -- England -- Nature. 2008 Feb 21;451(7181):1008-12. doi: 10.1038/nature06613.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. zarany1@partners.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18288196" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Hypoxia ; Cells, Cultured ; Gene Expression Regulation ; Hypoxia-Inducible Factor 1/metabolism ; Ischemia/*metabolism ; Mice ; Mice, Transgenic ; Muscle, Skeletal/metabolism ; *Neovascularization, Physiologic ; Oxygen/metabolism ; Receptors, Estrogen/metabolism ; Trans-Activators/deficiency/genetics/*metabolism ; Transcription Factors ; Transgenes/genetics ; Vascular Endothelial Growth Factor A/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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