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  • Springer  (34)
  • 2000-2004  (8)
  • 1990-1994  (16)
  • 1965-1969  (10)
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  • 1
    Electronic Resource
    Electronic Resource
    A photoisomerisation product of dieldrin (1966)
    Springer
    Bulletin of environmental contamination and toxicology 1 (1966), S. 127-132 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01844243
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  • 2
    Electronic Resource
    Electronic Resource
    A review of the molecular structure of tetanus toxin (1991)
    Springer
    Molecular and cellular biochemistry 107 (1991), S. 33-44 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary A discontinuous preparative polyacrylamide gel electrophoresis system has been developed and used to purify both the nicked and unnicked forms of tetanus toxin. The system was also used to prepare purified H and L chain peptides from the nicked toxin. The results show that the endogenous protease(s), which convert unnicked toxin to the nicked form, produce multiple species of nicked toxin, and heterogeneity in the H and L chains. The major amino termini of the toxins and their peptide components are: extract toxin, proline; filtrate toxin, proline, serine and asparagine; L chain, proline; and H chain, serine and asparagine. The L chain is located in the amino terminal position of the toxin molecule and the H chain the carboxy terminal end. A model is proposed to explain these results. Using the analytical ultracentrifuge, we have determined the molecular weights of extract and filtrate toxins to be 140 000 ± 5 000 and 128 000 ± 3 000, respectively. Using S DS-polyacrylamide gel electrophoresis we estimate the molecular weights of the H and L chains to be 87 000 and 48 000 daltons, respectively. Circular dichroic spectra of the toxins and their peptide components indicate that: the major tryptophanyl band in the toxin is contributed almost entirely by the H chain, the microenvironments of all the aromatics and disulfides in the two toxins appear to have small if any differences, the two toxins show little difference in their ordered secondary structure, and the two peptides when separated from one another still retain 80% of the helical structure that is present in the intact toxin but show a considerable loss of β-structure. The crystalline form of the nicked toxin has a hexagonal symmetry with two dimensional reciprocal lattice constants of 1/150 Å−1 and 1/150 Å−1. The crystals appear to belong to the two dimensional plane group P6 suggesting that each unit cell contains 6 or a multiple of 6 toxin molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214820
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  • 3
    Electronic Resource
    Electronic Resource
    Scaleup of Oral Extended-Release Dosage Forms (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 1800-1805 
    Details
    ISSN: 1573-904X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018946819849
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  • 4
    Electronic Resource
    Electronic Resource
    Application of BARE-1 retrotransposon markers to the mapping of a major resistance gene for net blotch in barley (2000)
    Springer
    Molecular genetics and genomics 264 (2000), S. 325-334 
    Details
    ISSN: 1617-4623
    Keywords: BARE-1 retrotransposon Barley Net blotch resistance Linkage mapping Quantitative trait locus (QTL)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Net blotch, which is caused by the fungus Pyrenophora teres Drechs. f. teres Smedeg., presents a serious problem for barley production worldwide, and the identification and deployment of sources of resistance to it are key objectives for many breeders. Here, we report the identification of a major resistance gene, accounting for 65% of the response variation, in a cross between the resistant line CI9819 and the susceptible cv. Rolfi. The resistance gene was mapped to chromosome 6H with the aid of two recently developed systems of retrotransposon-based molecular markers, REMAP and IRAP. A total of 239 BARE-1 and Sukkula retrotransposon markers were mapped in the cross, and the 30-cM segment containing the locus with significant resistance effect contained 26 of the markers. The type and local density of the markers should facilitate future map-based cloning of the resistance gene as well as manipulation of the resistance through backcross breeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380000326
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  • 5
    Electronic Resource
    Electronic Resource
    The accumulation of amino acids by various preparations of dog intestine (1965)
    Springer
    Cellular and molecular life sciences 21 (1965), S. 12-13 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé On a séparé le tissu intestinal en muqueuse et muscle, lesquels ont été incubés in vitro dans une solution d'acide aminé marqué; ainsi on a pu étudier l'absorption intracellulaire de l'acide aminé. On a trouvé que la musculature intestinale ne peut accumuler un acide aminé contre un gradient de concentration. Il semble qu'il existe dans le muscle une barrière contre la diffusion dont la significance est discutée.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02136353
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of ethacrynic acid and furosemide on the transport systems of the rat intestine (1968)
    Springer
    Naturwissenschaften 55 (1968), S. 232-233 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606224
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  • 7
    Electronic Resource
    Electronic Resource
    Rapid purification of transfected porcine muscle cells (2000)
    Springer
    Methods in cell science 22 (2000), S. 217-223 
    Details
    ISSN: 1573-0603
    Keywords: Flow cytometry ; Muscle cell ; Porcine ; Transfection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A detailed methodology is described for fluorescence-activated cell sorting (FACS) of porcine muscle cells that have been transfected to express green fluorescent protein (GFP). Cells are liberated from porcine skeletal muscle and primary cultures are transfected with DNA encoding GFP. Primary cultures are subjected to immunocytochemistry using a primary muscle-specific monoclonal antibody followed by incubation with a phycoerythrin-conjugated second antibody. Transfected myoblasts aresorted from fibroblasts using forward angle light scatter and ninety degree light scatter, phycoerythrin fluorescence, and GFP fluorescence. These procedures allow for isolation of genetically-engineered porcine muscle cells more rapidly than traditional clonal selection procedures. Consequently, FACS provides porcine myoblast populations that retain the majority of their replicative capacity and are not contaminated with non-myogenic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009856411749
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  • 8
    Electronic Resource
    Electronic Resource
    Programmed demethylation in CpG islands during human fetal development (1991)
    Springer
    Somatic cell and molecular genetics 17 (1991), S. 159-168 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The mechanism for establishing the DNA methylation patterns observed in adult mammalian tissues is not well understood. To determine when adult patterns are established for housekeeping genes, we examined the clustered CpGs in genes on the human active X chromosome (PGK, G6PD, P3, GdX, HPRT) and the autosomal gene,DHFR. We find unique methylation patterns present at theP3 locus in all tissues analyzed from 6- to 9-week fetal specimens, and at theHPRT locus in adrenal gland DNA at this stage of development. Adult patterns are established subsequently by demethylating specific CpGs. Our results show that demethylating events affecting CpG islands are programmed during mammalian fetal development. They suggest that the process of de novo methylation in the fetus methylates at least some sites in the 3′ region of the CpG islands in active genes and that adult patterns are established at 6–14 weeks developmental age by sequence-specific demethylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01232973
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  • 9
    Electronic Resource
    Electronic Resource
    Land application of poultry litter and water quality in Oklahoma, U.S.A. (1994)
    Springer
    Nutrient cycling in agroecosystems 40 (1994), S. 165-173 
    Details
    ISSN: 1573-0867
    Keywords: Animal manure ; eutrophication ; ground water ; nitrogen ; phosphorus ; surface runoff
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract With the rapid growth of the poultry industry in Oklahoma, U.S.A., more litter is applied to farm land. Thus, information is required on the impact of applications on regional soil and water resources. The effect of soil and poultry litter management on nitrogen (N) and phosphorus (P) loss in runoff and subsurface flow from four 16 m2 plots (Ruston fine sandy loam, 6 to 8% slope) was investigated under natural rainfall. Plots under Bermudagrass (Cynodon dactylon) received 11 Mg litter ha−1, which amounts to contributions of approximately 410 kg N and 140 kg P ha−1 yr−1. In spring, litter was broadcast on 3 of the plots; the upper half of one and total area of the other two. One of the total-area broadcast plots was tilled to 6 cm, the other remained as no till. The fourth plot served as a control. Relative to the control, litter application increased mean concentrations of total N and total P in runoff during the 16-week study for no-till (15.4 and 5.8 mg L−1) and tilled treatments (16.7 and 6.1 mg L−1). However, values for the half-area application (5.6 and 2.0 mg L−1) were similar to the control (5.7 and 1.3 mg L−1). Interflow (subsurface lateral flow at 70 cm depth) P was not affected by litter application; however, nitrate-N concentrations increased from 0.6 (control) to 2.9 mg L−1 (no till). In all cases, 〈 2 % litter N and P was lost in runoff and interflow, maintaining acceptable water quality concentrations. Although litter increased grass yield (8518 kg ha−1) compared to the control (3501 kg ha−1), yields were not affected by litter management. An 8-fold increase in the plant available P content of surface soil indicates long-term litter management and application rates will be critical to the environmentally sound use of this nutrient resource.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00750462
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  • 10
    Electronic Resource
    Electronic Resource
    DNA methylation of the fragile X locus in somatic and germ cells during fetal development: Relevance to the fragile X syndrome and X inactivation (1993)
    Springer
    Somatic cell and molecular genetics 19 (1993), S. 393-404 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract To obtain insights into mechanisms responsible for methylation of CpG islands on the inactive X chromosome of normal females, we examined methylation of the fragile X (FraX) locus in a variety of tissues from normal fetuses and adults, and from males with the FraX syndrome. We identified 20 CCGG sites (MspI-HpaII sites M1–M20) within a 12-kb BglII fragment that includes the CpG island. Sites M3–M18, within the 1.2-kb CpG island are unmethylated on the active X in normal males and females at all ages and in all tissues studied. In contrast, these sites are at least partially methylated on the inactive X chromosome in a variety of tissues from normal females by six weeks from conception. The exceptional tissues are chorionic villi and gonads, which are significantly undermethylated. In addition, fetal germ cells are unmethylated at site M3, which is methylated on the inactive X in other tissues; thus, the methylation imprint of the inactive X has been erased. Methylation of the locus on the fragile X chromosome is similar to that of the normal inactive X but is more extensive and less heterogeneous. This suggests that the expansion of the island and the greater number of CpGs that result from amplification of the CGG repeat enhance the methylatibility of the island. Additional studies show that the chromatin of the CpG island is nuclease hypersensitive on the active X but insensitive on both inactive and FraX.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01232750
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