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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 3 (1966), S. 175-185 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Summary In isolated receptors the impulse frequency following “step” stretches had a highly significant correlation with both muscle length and tension; any deviations from linearity were in opposite directions, impulse frequency rising more quickly than linearly with length and more slowly than linearly with tension. The impulse frequency decayed according to a power function of time from application of a step increase in length. A transfer function was derived and used to predict responses to sinusoidal and constant velocity stretches. The experimental data generally agreed with predictions. The deviations that were found could be accounted for by considering quantitatively any non-linearity between frequency and length, the adaptation of the impulse frequency to constant currents, the all-or-none nature of the action potential, and the viscous forces present during dynamic stretch. The approximately linear relationship between impulse frequency and muscle length and muscle tension is discussed. Muscle tension appears to be the more direct causal agent of impulse generation. Possible physical bases for the transfer function are also considered.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 24 (1968), S. 1210-1211 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé On a enregistré des décharges de 17 fibres fusimotrices dont on suppose l'existence dans les filaments de racines ventrales des chats décérébrés. 8 fibres ont été inhibées par stimulation répétée de la portion centrale isolée du reste de la racine ventrale. Ces résultats montrent qu'il existe une inhibition antidromique dans les neurones fusimoteurs.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Empirical economics 14 (1989), S. 273-289 
    ISSN: 1435-8921
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract This paper makes use of the fact that the stock of medical manpower in Canada is institutionally and exogenously determined in order to develop a model predicting physician average net income. An econometric evaluation of this model on a sample involving Canada's ten provinces during 1968–1982 suggests that a one per cent increase in physician fees increases physician average net income by 0.70 per cent, and a one per cent increase in the physician to population ratio reduces average net income by 0.62 per cent. In both cases, the elasticities are less than unity because the supply function for an individual physician is backward bending — on average, a Canadian physician reduces his hours worked by an amount between 0.17 and 0.50 per cent (95 per cent confidence interval) if his real wage rate is increased by one per cent.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 16 (1978), S. 408-418 
    ISSN: 1741-0444
    Keywords: Activity ; Metrifonate ; Oxamniquine ; Schistosome ; Ultrasonics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Il décrit une méthode de mise au point et d'application in vitro, de l'effet de médicaments antischistosome sur l'activité des schistosomes. Le système décrit enregistre l'activité de troubles causés par les mouvements des vers, dans un champ ultrasonore de 10 MHz. Les enregistrements de l'activité, allant jusqu'à 10 canaus, sont relevés par ordinateur, et les changements d'activité sont évalués au moyen de statistique. On démontre et étudie les changement d'activité, dus aux réactions des Métrifonate et Oxamniquine.
    Abstract: Zusammenfassung Eine Methode zur Feststellung der Wirkung schistosomalhemmender Medikamente auf die Tätigkeit der Schistosomen in vitro wurde erarbeitet und ausgewertet. Die Methode erläutert Tätigkeitsaufzeichnungen, der durch die Wurmbewegungen erzeugten Unregelmäßigkeiten in einem 10 MHz Ultraschallfeld. Tätigkeitsaufzeichnungen von bis zu 10 Kanälen werden von einem Computer aufgezeichnet und die Tätigkeitsveränderungen werden zufriedenstellend ausgewertet. Es werden die Tätigkeitsveränderungen in bezug auf Metrifonate und Oxamniquine dargestellt und diskutiert.
    Notes: Abstract A method of assessing the effect of antischistosomal drugs on the activity of schistosomes,in vitro has been devised and exploited. The system described records activity from the disturbances caused by the worm movements in a 10 MHz ultrasonic field. Activity recordings from up to 10 channels are plotted by computer, and changes in activity evaluated statistically. The activity changes in response to Metrifonate and to Oxamniquine are demonstrated and discussed
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Parasitology research 58 (1979), S. 169-174 
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of praziquantel, a novel antischistosomal compound, on the activity of adultSchistosoma mansoni (Liverpool strain) in vitro were investigated. Worm activity was modified at all concentrations of praziquantel. High concentrations (above 0.5 μg/ml) produced rapid paralysis, whilst low concentrations of praziquantel stimulated worm activity. It is concluded that such activity modification could lead to worm displacement in vivo.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 16 (1978), S. 597-598 
    ISSN: 1741-0444
    Keywords: Activity monitoring ; Oxaminiquine ; Schistosomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 1968-12-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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  • 8
    Publication Date: 2014-07-01
    Description: Ages retrieved from accessory minerals in high-grade metamorphic rocks place important constraints on the timing of events and the rates of tectonometamorphic processes operating in the deep crust. In suprasolidus rocks, the dissolution and growth of zircon and monazite are strongly dependent on the P–T conditions of metamorphism and the chemistry and quantity of anatectic melt present. Along a clockwise P–T path, prograde heating above the solidus leads to episodic melt loss and changes in melt chemistry that have important implications for the dissolution and growth of zircon and monazite. In this study, phase equilibria modelling of open-system melting is coupled with experimental data on zircon and monazite solubility to evaluate the stability of these minerals at suprasolidus conditions along several schematic clockwise P–T paths. In migmatite melanosomes and residual granulites, some zircon is expected to survive heating to peak temperature and subsequent isothermal decompression, whereas monazite may be completely consumed, consistent with the observation that inherited cores are less common in monazite than in zircon. After decompression, during cooling to the solidus, new zircon and monazite growth from melt trapped along grain boundaries in melanosomes and residual granulites is expected to be limited. By contrast, leucosomes in migmatites and anatectic granites are predicted to contain mostly newly formed zircon and monazite with minimal inherited components, unless significant entrainment of these minerals from the source occurs. The preservation of cores inside newly formed zircon, as observed in many anatectic granites, demonstrates that segregation, ascent and emplacement is commonly fast enough to limit dissolution of these inherited grains.
    Print ISSN: 0016-7649
    Topics: Geosciences
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  • 9
    Publication Date: 2014-01-16
    Description: Partial melting and melt drainage from deep suprasolidus crust in orogens has important consequences for tectonics. Melt extraction along prograde segments of clockwise P – T paths reduces fertility and increases the density and strength of residual crust, which has implications for further melt production during decompression. Using calculated P – T phase diagrams, implications of stepwise melt loss along clockwise P – T paths for pelite and greywacke are assessed, and density of the progressively more residual source and the potential role of buoyancy in the exhumation of deep crustal rocks are evaluated. Two model P – T paths are considered: isobaric heating at 1.2 GPa followed by decompression to 0.4 GPa at 750, 820 and 890 °C, and prograde heating from the fluid-present solidus at 1.2 GPa to 860 °C at 1.8 GPa followed by isothermal decompression to 0.4 GPa. Both closed-system (undrained) and conditionally open-system (drained by intermittent melt loss) conditions are assessed. If melt is drained along clockwise P – T paths in suprasolidus crust then lower quantities of melt will be generated during decompression than sometimes inferred in tectonic models. Instead, the role of melt transfer through suprasolidus crust and melt accumulation at shallow levels in the anatectic zone should be considered rather than simply invoking the generation of large volumes of melt in decompressing crust.
    Print ISSN: 0016-7649
    Topics: Geosciences
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  • 10
    Publication Date: 1966-11-01
    Print ISSN: 0340-1200
    Electronic ISSN: 1432-0770
    Topics: Biology , Computer Science , Physics
    Published by Springer
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