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A multichannel ultrasonic activity monitor forin-vitro screening of antischistosomal drugs

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Abstract

A method of assessing the effect of antischistosomal drugs on the activity of schistosomes,in vitro has been devised and exploited. The system described records activity from the disturbances caused by the worm movements in a 10 MHz ultrasonic field. Activity recordings from up to 10 channels are plotted by computer, and changes in activity evaluated statistically. The activity changes in response to Metrifonate and to Oxamniquine are demonstrated and discussed

Sommaire

Il décrit une méthode de mise au point et d'application in vitro, de l'effet de médicaments antischistosome sur l'activité des schistosomes. Le système décrit enregistre l'activité de troubles causés par les mouvements des vers, dans un champ ultrasonore de 10 MHz. Les enregistrements de l'activité, allant jusqu'à 10 canaus, sont relevés par ordinateur, et les changements d'activité sont évalués au moyen de statistique. On démontre et étudie les changement d'activité, dus aux réactions des Métrifonate et Oxamniquine.

Zusammenfassung

Eine Methode zur Feststellung der Wirkung schistosomalhemmender Medikamente auf die Tätigkeit der Schistosomen in vitro wurde erarbeitet und ausgewertet. Die Methode erläutert Tätigkeitsaufzeichnungen, der durch die Wurmbewegungen erzeugten Unregelmäßigkeiten in einem 10 MHz Ultraschallfeld. Tätigkeitsaufzeichnungen von bis zu 10 Kanälen werden von einem Computer aufgezeichnet und die Tätigkeitsveränderungen werden zufriedenstellend ausgewertet. Es werden die Tätigkeitsveränderungen in bezug auf Metrifonate und Oxamniquine dargestellt und diskutiert.

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References

  • Arthur, B. W., Casida, J. E. (1957) Metabolism and selectivity of O, O-dimethyl 2,2,2-trichlorol-1-hydroxyethyl phosphonate and its acetyl and derivatives.J. Ag. & Food Chem. 5, 186–192.

    Article  Google Scholar 

  • Brown, M. C., Koura, M., Bell, D. R., Gilles, H. M. (1973) Anin vitro activity monitor for schistosomes: preliminary report.Ann. Trop. Med. & Parasit. 67, 3, 369–370.

    Google Scholar 

  • Coles, G. C. (1975) The response ofSchistosoma mansoni maintainedin vitro to schistosomicidal compounds.J. Helminth. 49, 205–209.

    Article  Google Scholar 

  • Henry, W., Girgis, N. I., Mansour, N. S. (1976)In vitro studies on the use of penicillamine with tartar emetic againstSchistosoma mansoni worms.Ann. Trop. Med. & Parasit. 70, 425–429.

    Google Scholar 

  • Hillman, G. R., Olsen, N. J., Senft, A. W. (1974) Effect on Methysergide and Dihydroergotamine onSchistosoma mansoni.J. Pharmacol. & Exp. Therapeutics 188, 529–535.

    Google Scholar 

  • Hillman, G. R., Senft, A. W. (1973) Schistosome motility measurements: Response to drugs.185, 177–184.

    Google Scholar 

  • Hillman, G. R., Senft, A. W. (1975) Anticholinergic properties of the antischistosomal drug Hycanthone.Am. J. Trop. Med. & Hygiene 24, 877–884.

    Google Scholar 

  • Jewsbury, J. M., Homewood, C. A., Marshall, I. (1977) Inexpensive apparatus for measuring activity ofSchistosoma mansoni in vitro.Trans. R. Soc. Trop. Med. & Hygiene 71, 115.

    Google Scholar 

  • Senft, A. W., Hillman, G. R. (1973) Effect of Hycanthone Niridazole and Antimony Tartrate on schistosome motility.Am. J. Trop. Med. & Hygiene 22, 734–742.

    Google Scholar 

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Authors and Affiliations

  1. Bioengineering and Medical Physics Unit, University of Liverpool, L69 3BX, Liverpool, England

    M. C. Brown

  2. Liverpool School of Tropical Medicine, Pembroke Place, L3 50A, Liverpool, England

    D. F. Norman, D. R. Bell & C. J. Chavasse

Authors
  1. M. C. Brown
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  2. D. F. Norman
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  3. D. R. Bell
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  4. C. J. Chavasse
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Brown, M.C., Norman, D.F., Bell, D.R. et al. A multichannel ultrasonic activity monitor forin-vitro screening of antischistosomal drugs. Med. Biol. Eng. Comput. 16, 408–418 (1978). https://doi.org/10.1007/BF02442658

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  • DOI: https://doi.org/10.1007/BF02442658

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