Summary
The effects of praziquantel, a novel antischistosomal compound, on the activity of adultSchistosoma mansoni (Liverpool strain) in vitro were investigated.
Worm activity was modified at all concentrations of praziquantel. High concentrations (above 0.5 μg/ml) produced rapid paralysis, whilst low concentrations of praziquantel stimulated worm activity. It is concluded that such activity modification could lead to worm displacement in vivo.
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Chavasse, C.J., Brown, M.C. & Bell, D.R. Schistosoma mansoni: Activity responses in vitro to praziquantel. Z. Parasitenkd. 58, 169–174 (1979). https://doi.org/10.1007/BF01951341
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DOI: https://doi.org/10.1007/BF01951341