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  • 1
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 46 (1994), S. 275-277 
    ISSN: 1432-1041
    Keywords: Prostaglandin E1 ; Infusion ; pharmacokinetics ; metabolism ; volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract In a single-blind, randomized, two-way crossover study with 12 healthy male volunteers, 60 μg of prostaglandin E1 (PGE1) or placebo was administered by intravenous infusion during a 120-min period. PGE1, 13,14-dihydro-PGE1 (PGE0) and 15-keto-PGE0 plasma concentrations were measured by a highly specific and sensitive GC-MS/MS method. Endogenous PGE1 plasma concentrations ranged between 1.2 and 1.8 pg·ml−1. Endogenous PGE0 and 15-keto-PGE0 plasma concentrations varied from 0.8 to 1.3 pg·ml−1 and from 4.2 to 6.0 pg/ml respectively. During intravenous infusion of PGE1, plasma PGE1 concentrations rose to a level twice as high as during the placebo infusion. In contrast, PGE0 plasma concentrations were 8 times higher during PGE1 infusion than during placebo infusion, and 15-keto-PGE0 plasma concentrations were 20 times higher. The new analytical method has thus been useful to describe the pharmacokinetics of PGE1 and its metabolites PGE0 and 15-keto-PGE0, during and after intravenous infusion of PGE1.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 830-832 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The switching dynamics between TE- and TM-polarization states is studied in a strained ridge-waveguide InGaAsP/InP laser that exhibits TE/TM bistability. Using current modulation with frequencies between 50 and 500 MHz, three types of emission are distinguished. With increasing modulation amplitude, the laser runs through a region of TE emission, a range of stochastic switching between TE and TM modes, and a third region of regular polarization switching. The minimum modulation amplitude for regular switching rises strongly with frequency while the respective switching times decrease from about 700 ps at 50 MHz down to 250 ps around 500 MHz, corresponding to gigahertz mode switching.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 1442-1455 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effect of particulate volume fraction vp and diameter dp on the composite Young's modulus Ec is studied both experimentally, using a silica bead/epoxy system, as well as with the help of computer simulations. The experimental and simulation results show that for a given particulate size, the overall Ec vs vp curve displays a concave upward shape and not a linear shape. This superlinear trend of the data implies that the average strain normalized to the applied strain λ=ε¯p/εc transferred to the particulates increases with volume fraction. The above finding is explained in terms of a mean-field picture, where a single particle interacts with an effective medium consisting of the remaining particles embedded in the matrix. As the modulus of the effective medium surrounding a reference particle increases with vp, the modulus mismatch between the reference particulate and the medium is consequently reduced. This leads to an overall increase in the normalized average strain λ transferred to each particulate as vp is increased. The experimental results using silica particulates with various sizes dp, as well as the simulation results, show that smaller particulates provide an increased composite modulus as compared to larger particulates, at constant vp. General equations are developed, which relate the composite modulus to the average particle stress or strain, given only information about the volume fraction and the Young's modulus of each of the phases present.Through the application of these relations, it is found that smaller particulates display a greater amount of normalized average strain λ transferred than larger particulates. The effect of particulate Young's modulus Ep in combination with particulate size on the resulting Ec is also studied using simulations only. It is found that for a low particulate to matrix modulus ratio Ep/Em, the particulate size has very little influence on Ec. Moreover, the shape of the Ec vs vp curve can be well approximated by a straight line up to large values of vp. On the other hand, as the ratio Ep/Em is increased, the superlinear trend of the composite modulus Ec vs vp data is more apparent. This results in a smaller range of the Ec vs vp curve, which can be approximated by a linear function. It is also found that the extent of this linear region also decreases with particle size.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 104 (1991), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: The remanent magnetization of Palaeozoic and Mesozoic carbonates from the Tibetan Sedimentary Series (TSS) of the Manang area north of the Annapurna Range (north central Nepal) has been investigated. the TSS forms part of the tectonic unit between the Indian-Eurasian plate boundary in the north and the Main Central Thrust (MCT) in the south.Apart from a present field direction, three remanence components have been separated: a normal polarity, post-folding remanence (negative fold test) is carried by pyrrhotite (the core corrected mean direction for five sites with 47 specimens from Silurian/Devonian rocks is decl. = 312.9°, incl. = 58.3°α95= 17.6°, K= 19.8). the origin of this component is not understood.A more precisely determined, reversed polarity, post-folding remanence (99 per cent negative fold test) is also carried by pyrrhotite (the core corrected mean direction for 12 sites with 229 specimens from Carboniferous/Triassic rocks is decl. = 196.4°, incl. = -65.9°, α95= 3.2°, k = 183).One site of Lower Carinan age shows—in addition to the pyrrhotite component— a second, stable remanence direction carried by magnetite. the fold test is 99 per cent positive and there is a high probability that the remanence is of detrital origin (the bedding corrected direction for one site with 40 specimens is decl. =334.3°, incl. = -54.1°, α95= 4.2°, k = 30.2, palaeolatitude 34.6°S).The direction of the magnetite component coincides with other Triassic palaeodirection data from the literature and the inclination suggests a palaeoposition of the TSS at the northern margin of India at this time. the northern extent of India in the Triassic cannot be reconstructed from the data because of the strong anticlockwise rotation (48°) of stable India since this time.The inclination of the reverse polarity pyrrhotite component is 19° steeper than expected from the maximum northern position of the area. This suggests a regional northward tilt along the MCT which is supported by steep inclinations found in other areas.Declination data for the reverse polarity pyrrhotite component and for the magnetite component deviate clockwise from expected values for the area by 23°-34° (calculated from the Indian APWP). Utilizing Klootwijk, Conaghan & Powell's (1985) rotational underthrusting model, the minimum magnitude of continental underthrusting between the TSS and stable India at the longitude of central Nepal (84°E) has been calculated from the declination of our reverse polarity pyrrhotite component. A possible range of 520–1100 km results from consideration of different tectonic models.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 71 (1992), S. 551-556 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The interaction of continuous CO2 laser radiation with water is described. Tightly focused radiation at powers of up to 120 W is used to generate and maintain a conical depression in the water surface similar to the keyhole created during laser penetration welding. The observed penetration depth of up to 7 mm is explained in terms of a hydrodynamic model and observations on the interaction induced liquid flows are described. The momentum reaction to the flow of steam up out of the keyhole generates a downward flow in the liquid around the keyhole with a velocity of ∼20 cm/s under the conditions of these experiments. The experiment has also been performed under variable gravity conditions provided by the NASA KC-135 Microgravity Aircraft to observe effects associated with changes in hydrostatic pressure and buoyancy on the system.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The new Schwerionen-Synchrotron (SIS)/Experimenteller Speicher-Ring (ESR) heavy ion accelerator facility [Nucl. Instrum. Methods A 278, 7, 19 (1989)], built for basic atomic and nuclear physics at Darmstadt (Federal Republic of Germany), also provides unique possibilities to study rf accelerator and beam/target interaction physics for inertial confinement fusion driven with heavy ion beams. It is the first machine that offers this opportunity. Beam parameters and experiments planned over the next five years are discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 60 (1992), S. 3212-3214 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new method to determine the proton concentration in LiNbO3 is presented. The method is based on the measurement of the diffraction efficiency of a photorefractive grating in two situations. It is first measured after recording at room temperature, and second after saturation of the fixing process at a given temperature (about 150 °C). From only these two experimental data, the value obtained for the proton concentration in our sample is H0=(4.4±0.7)×1018 cm−3. This value agrees, within the experimental error, with that obtained from the infrared absorption arising from the OH− stretching bond.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 57 (1990), S. 2517-2519 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have realized a novel wavelength division multiplexer/demultiplexer based on rib waveguides in GaInAsP/InP. The device is a strongly asymmetric codirectional coupler with periodic variation of the coupling constant and has sinc2-type characteristics. Our devices have center wavelengths around 1.3 μm, filter half-widths 10–15 nm, and far end isolation down to −17 dB. The structure is suited for integration into optoelectronic integrated circuits for applications in bidirectional optical communication systems.
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