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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical evidence that Patched is the Hedgehog receptor (1996)
    [s.l.] : Nature Publishing Group
    Nature 384 (1996), S. 176-179 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Epistasis analysis has implicated a number of genes as acting downstream of hh in Drosophila', including patched (ptc)6'1. Transcription of hh targets is repressed in cells expressing ptc, and hh acts to antagonize ptc activity, resulting in the induction of the target genes8"10. Although it acts ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/384176a0
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex (2005)
    [s.l.] : Nature Publishing Group
    Nature 436 (2005), S. 261-265 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A substantial decrease in the number of synapses occurs in the mammalian brain from the late postnatal period until the end of life. Although experience plays an important role in modifying synaptic connectivity, its effect on this nearly lifelong synapse loss remains unknown. Here we used ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature03715
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization and Antibacterial Effect of a Novel Nanocomposite Membrane (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 325-328 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In this experiment, un-dried silver-hydroxyapatite-titania nanoparticles slurry was used tomake membrane with Polyamide-66 by co-polymerization method. The morphology, chemicalcomponents and structures of the membrane were characterized by AAS, XRD, SEM and EDX. S.aureus, E. eoli, P.gingivalis, F.nucleatum and S.mutans were utilized to test the antibacterial effect.XRD results demonstrated that the membrane have characteristic diffraction peaks of pure HA. Ahomogeneous distribution of the Ca, P, Ti, and Ag element in the membrane was confirmed byEDX. Both surface and section showed porous structure which was confirmed by SEM and theholes size was average 20-30μm. The bacteria assay reflects to the antibacterial effect, 56.31 % ofS. aureus and 50.10 % of E. eoli were killed after 24 hours incubation. However, 91.84 % of P.gingivalis, 90.64 % of F. nucleatum and 90.49 % of S. mutans were killed and pictures of SEMshowed obviously fewer cells on the surface. So the nanocomposite membrane could be one of thebioactive materials with antibacterial properties for oral GBR technique
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.325.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Nano-Hydroxyapatite/Polymer Composite Scaffold for Bone Tissue Engineering (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 365-368 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Nano-hydroxyapatite/polyamide66 (n-HA/PA66) composite scaffolds are prepared usingphase separation and phase separation in combination with particle leaching, and both thecomposite powder and paste are used as starting materials. The composite is characterized by IRand XRD. The micro-architecture of the scaffolds is observed by SEM, and the mechanisms that theformation of the porous structure follows have been investigated preliminarily. The results showthat scaffold prepared by phase separation in combination with particle leaching method usingcomposite powder as starting material possesses controllable porosity and interconnectivity, as wellas good mechanical strength comparable to human cancellous bone, suitable for being thetissue-engineered scaffold for load-bearing bone repair. Furthermore, scaffold made by phaseseparation using composite paste as starting material exhibits an anisotropy both in morphology andmechanical properties, which indicates the potential of guiding cell seeding, distribution and newtissue formation in preferential direction
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.365.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Influences of the Crystallization Behavior of n-HA Reinforced PA66 Biocomposite on Its Mechanical Properties (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 510-511 (Mar. 2006), p. 898-901 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The crystallization behavior of n-HA/PA66 biocomposites at different processingpressure and annealing temperature were investigated by XRD and DSC. The results showed that increasing annealing temperature would weaken the crystalline intensities of pure PA66 and its composites. For n-HA/PA66 composites, the peaks of α1 crystals of PA66 disappeared, only α2 crystals existed, and with the increase of injection pressure and annealing temperature, the crystalline intensity of PA66 decreased. The degree of crystallinity (Xc) of PA66 in composites increased with the increase of injection pressure, however, annealing temperature had no obviouseffects on crystalline degree. The mechanical properties had close relationship with the crystallization behavior of the materials
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/12/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.510-511.898.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Antibacterial Effect and Security Evaluation on Nano-Hydroxyapatite Bearing Cu〈sup〉2+〈/sup〉 and Zn〈sup〉2+〈/sup〉 (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 510-511 (Mar. 2006), p. 890-893 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Nano-hydroxyapatite (n-HA) slurry was synthesized at normal pressure, and (Cu2+, Zn2+)-bearing nano-hydroxyapatite (Cu-Zn-HA) was prepared by ion exchange reaction in water medium. The properties of n-HA and Cu-Zn-HA were characterized by AAS, TEM, XRD and FTIR. The results of XRD analysis indicate that Cu2+ and Zn2+ can occupy Ca2+ sites and enter the crystal lattice of hydroxyapatite. Through the antibacterial experiments, it was found that Cu-Zn-HA had better antibacterial ability on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). After heat treatment at 400℃ for an hour, the materials still had good antibacterial effect. The accelerated aging method was employed to test antibacterial durability of the material and the results indicated that the durability was good. The results of the security assessment, including skin stimulation testof rabbit, acute toxicity test by stomach filling and the micronucleus test in bone marrow polychromatic erythrocytes of mice, showed that the security of the material was excellent
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/12/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.510-511.890.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Preparation of Nano-Hydroxyapatite/Polyamide6 Composite Porous Scaffold for Bone Tissue Engineering (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 544-545 (May 2007), p. 793-796 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Scaffold in bone tissue engineering must have a three-dimensional (3-D) interconnectedporous structure acting as a template for bone tissue regeneration, and material fabricating thescaffold must be biocompatible and can provide structural support during bone growth andremodeling at the same time. In this paper, a method of phase separation and particle leachingcombined (PS/PL) was used to prepare porous scaffold of nano-hydroxyapatite and polyamide6(n-HA/PA6) composite. The results show that the scaffold prepared by PS/PL has not onlyinterconnected macropores of 100~300 μm, but also micropores on the walls of macropores, andPS/PL scaffold is more interconnective in compare with phase separation (PS) scaffold. When theporosity of the scaffold is about 79%, its compressive strongth is about 3.27 MPa, that is similar tothe human cancellous bone(2~10MPa). Ethanol has some effect on hydrogen bonds, but fabricatingmethod will not change the chemical component of the composite. The porous scaffold is prospectfor bone tissue engineering
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/15/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.544-545.793.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of Compatibilizers on the Properties of Nano-Hydroxyapatite Reinforced Polyamide 66 and High Density Polyethylene Blends (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 510-511 (Mar. 2006), p. 978-981 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The compatibility efficiency on different compatibilizer for nano-hydroxyapatite(n-HA) reinforced polyamide 66 (PA66) and high density polyethylene (HDPE) blends at a composition of 40/42/18 as functionalized biomaterial was investigated by mechanical properties testing and scanning electron microscopy (SEM). The results showed that mechanical properties of compatibilized blends were much improved by the compatibilizers of maleic anhydride graftedpolyethylene (PE-g-MAH) and ethylene/methacrylic acid ionomer-sodium ion (ION) compared with the uncompatibilized blends. Blends had peak mechanical values of different compatibilizer. Both PE-g and ION formed adhesion during melt mixing and stabilized the morphology and significantly reduced the size of dispersed PE phase. PE-g gave the blends with PE spheres ranging from 1 to 4µm and ION with well-dispersed spheres with an average diameter of 1µm. The moreenlarged interphase of the blends containing ION reduced the lower interfacial energy to increase the miscibiliy of the blends. Consequently, ION had better contribution to rigidity properties than PE-g for n-HA/PA/PE blends
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/12/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.510-511.978.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Study on the Biomimetic Properties of Bone Substitute Material: Nanohydroxyapatite/Polyamide 66 Composite (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 510-511 (Mar. 2006), p. 938-941 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: To compare with the human cortical bone, the biomimetic properties ofnano-hydroxyapatite/polyamide 66 composite (n-HA/PA66) were preliminarily studied qualitatively and quantitatively with TEM, XRD in crystal morphology, phase composition and crystal structure. A series of structure parameters such as cell lattice parameters (a and c), mean crystallite size and micro-strain were calculated to characterize quantitatively the microstructure of n-HA/PA66 andhuman cortical bone at the atomic level. The results show that n-HA/PA66 is a good biomimetic biomaterial. But there still are some differences between n-HA/PA66 and human cortical bone. Compared to human cortical bone, the crystal microstructure of n-HA/PA66 is denser, the crystal lattice of n-HA is more perfect and the distortion of crystal lattice decreases
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/12/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.510-511.938.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Fabrication of n-HA/CS Porous Scaffold Carrying Ampicillin-Loaded Microspheres (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 544-545 (May 2007), p. 941-944 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In the paper, ampicillin-loaded alginate(ALG) microspheres covered with chitosan (CS)were firstly prepared by emulsification/internal gelation method. These microspheres were mixedwith n-HA/CS composite and then were fabricated into porous scaffold carrying micropheres bygas-foaming together with phase-separation. their properties were characterized by the methods ofscanning electronic microscopy (SEM), X-ray diffraction (XRD), infrared spectroscopy (IR) andinversed microscope. The drug releasing rate and entrapment efficiency were tested byspectrophotometry at 203 nm. The results show that the porous scaffold carrying microspheres hasgood property of slow drug releasing rate. The research will offer a new kind of degradable porousscaffold with good property of controlled drug release for bone or cartilage repairing
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/15/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.544-545.941.pdf
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