Publication Date:
2014-12-11
Description:
Three new phthalides, gnaphalides A–C ( 1 – 3 , resp.), together with three known phthalides, were isolated from the aerial part of Gnaphalium adnatum. The structures of the new compounds were elucidated as 6-(1,1-dimethylprop-2-en-1-yl)-5,7-dihydroxy-2-benzofuran-1(3 H )-one ( 1 ), 5-hydroxy-7-[(2-hydroxy-3-methylbut-3-en-1-yl)oxy]-2-benzofuran-1(3 H )-one ( 2 ), and 1,3-dihydro-7-[(3-methylbut-2-en-1-yl)oxy]-1-oxo-2-benzofuran-5-yl β - D -glucopyranoside ( 3 ) on the basis of spectral analyses. The structure of 1 was also confirmed by X-ray crystallographic analysis. The three known phthalides, identified as 5,7-dihydroxyisobenzofuran-1(3 H )-one ( 4 ), anaphatol ( 5 ), and 7- O -( β -glucopyranosyl)-5-hydroxyisobenzofuran-1(3 H )-one ( 6 ), were isolated from the genus Gnaphalium for the first time.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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