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  • 1
    Publication Date: 2015-08-05
    Description: Infection of cells with DNA viruses triggers innate immune responses mediated by DNA sensors. cGMP-AMP synthase (cGAS) is a key DNA sensor that produces the cyclic dinucleotide cGMP-AMP (cGAMP) upon activation, which binds to and activates stimulator of interferon genes (STING), leading to IFN production and an antiviral response. Kaposi’s...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2014-10-31
    Description: Article The fission yeast, Schizosaccharomyces pombe , is a valuable model organism, but the lack of a portable RNA Pol III promoter has prevented the implementation of the CRISPR/Cas9 system. Here the authors develop a CRISPR/Cas9 system that achieves selection-free specific mutagenesis with very high efficiencies in S. pombe . Nature Communications doi: 10.1038/ncomms6344 Authors: Jake Z. Jacobs, Keith M. Ciccaglione, Vincent Tournier, Mikel Zaratiegui
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 3
    Publication Date: 2014-06-19
    Description: Maternal infection during pregnancy increases the risk for schizophrenia in offspring. In rodent models, maternal immune activation (MIA) yields offspring with schizophrenia-like behaviors. None of these behaviors are, however, specific to schizophrenia. The presence of hallucinations is a key diagnostic symptom of schizophrenia. In mice, this symptom can be defined...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 4
    Publication Date: 2014-07-11
    Description: Author(s): Daniel B. Larremore, Aaron Clauset, and Abigail Z. Jacobs Bipartite networks are a common type of network data in which there are two types of vertices, and only vertices of different types can be connected. While bipartite networks exhibit community structure like their unipartite counterparts, existing approaches to bipartite community detection have dra... [Phys. Rev. E 90, 012805] Published Thu Jul 10, 2014
    Keywords: Networks and Interdisciplinary Physics
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
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  • 5
    Publication Date: 2002-01-12
    Description: In the Eurasian Upper Paleolithic after about 35,000 years ago, abstract or depictional images provide evidence for cognitive abilities considered integral to modern human behavior. Here we report on two abstract representations engraved on pieces of red ochre recovered from the Middle Stone Age layers at Blombos Cave in South Africa. A mean date of 77,000 years was obtained for the layers containing the engraved ochres by thermoluminescence dating of burnt lithics, and the stratigraphic integrity was confirmed by an optically stimulated luminescence age of 70,000 years on an overlying dune. These engravings support the emergence of modern human behavior in Africa at least 35,000 years before the start of the Upper Paleolithic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henshilwood, Christopher S -- d'Errico, Francesco -- Yates, Royden -- Jacobs, Zenobia -- Tribolo, Chantal -- Duller, Geoff A T -- Mercier, Norbert -- Sealy, Judith C -- Valladas, Helene -- Watts, Ian -- Wintle, Ann G -- New York, N.Y. -- Science. 2002 Feb 15;295(5558):1278-80. Epub 2002 Jan 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Iziko Museums of Cape Town, South African Museum, Post Office Box 61, Cape Town, 8000, South Africa. chenshilwood@iziko.org.za〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11786608" target="_blank"〉PubMed〈/a〉
    Keywords: *Aluminum Silicates ; Animals ; *Archaeology ; *Behavior ; Cognition ; *Engraving and Engravings ; *Geologic Sediments ; *Hominidae ; Humans ; South Africa ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2011-10-15
    Description: The conceptual ability to source, combine, and store substances that enhance technology or social practices represents a benchmark in the evolution of complex human cognition. Excavations in 2008 at Blombos Cave, South Africa, revealed a processing workshop where a liquefied ochre-rich mixture was produced and stored in two Haliotis midae (abalone) shells 100,000 years ago. Ochre, bone, charcoal, grindstones, and hammerstones form a composite part of this production toolkit. The application of the mixture is unknown, but possibilities include decoration and skin protection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henshilwood, Christopher S -- d'Errico, Francesco -- van Niekerk, Karen L -- Coquinot, Yvan -- Jacobs, Zenobia -- Lauritzen, Stein-Erik -- Menu, Michel -- Garcia-Moreno, Renata -- 249587/European Research Council/International -- New York, N.Y. -- Science. 2011 Oct 14;334(6053):219-22. doi: 10.1126/science.1211535.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Archaeology, History, Culture and Religion, University of Bergen, Bergen, Norway. christopher.henshilwood@ahkr.uib.no〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21998386" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; *Cognition ; Coloring Agents/*history ; *Geologic Sediments ; Geological Phenomena ; History, Ancient ; Humans ; South Africa
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2004-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henshilwood, Christopher -- d'Errico, Francesco -- Vanhaeren, Marian -- van Niekerk, Karen -- Jacobs, Zenobia -- New York, N.Y. -- Science. 2004 Apr 16;304(5669):404.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Development Studies, University of Bergen, Norway. chris@blomboscave.co.za〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15087540" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Archaeology ; Art ; *Culture ; Humans ; Snails ; *Social Behavior ; South Africa ; *Symbolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2012-11-09
    Description: There is consensus that the modern human lineage appeared in Africa before 100,000 years ago. But there is debate as to when cultural and cognitive characteristics typical of modern humans first appeared, and the role that these had in the expansion of modern humans out of Africa. Scientists rely on symbolically specific proxies, such as artistic expression, to document the origins of complex cognition. Advanced technologies with elaborate chains of production are also proxies, as these often demand high-fidelity transmission and thus language. Some argue that advanced technologies in Africa appear and disappear and thus do not indicate complex cognition exclusive to early modern humans in Africa. The origins of composite tools and advanced projectile weapons figure prominently in modern human evolution research, and the latter have been argued to have been in the exclusive possession of modern humans. Here we describe a previously unrecognized advanced stone tool technology from Pinnacle Point Site 5-6 on the south coast of South Africa, originating approximately 71,000 years ago. This technology is dominated by the production of small bladelets (microliths) primarily from heat-treated stone. There is agreement that microlithic technology was used to create composite tool components as part of advanced projectile weapons. Microliths were common worldwide by the mid-Holocene epoch, but have a patchy pattern of first appearance that is rarely earlier than 40,000 years ago, and were thought to appear briefly between 65,000 and 60,000 years ago in South Africa and then disappear. Our research extends this record to ~71,000 years, shows that microlithic technology originated early in South Africa, evolved over a vast time span (~11,000 years), and was typically coupled to complex heat treatment that persisted for nearly 100,000 years. Advanced technologies in Africa were early and enduring; a small sample of excavated sites in Africa is the best explanation for any perceived 'flickering' pattern.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, Kyle S -- Marean, Curtis W -- Jacobs, Zenobia -- Schoville, Benjamin J -- Oestmo, Simen -- Fisher, Erich C -- Bernatchez, Jocelyn -- Karkanas, Panagiotis -- Matthews, Thalassa -- England -- Nature. 2012 Nov 22;491(7425):590-3. doi: 10.1038/nature11660. Epub 2012 Nov 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Archaeology, University of Cape Town, Rondebosch 7701, South Africa.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23135405" target="_blank"〉PubMed〈/a〉
    Keywords: Archaeology ; History, Ancient ; Humans ; South Africa ; Technology/*history ; Time Factors ; Weapons/*history
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2008-11-01
    Description: The expansion of modern human populations in Africa 80,000 to 60,000 years ago and their initial exodus out of Africa have been tentatively linked to two phases of technological and behavioral innovation within the Middle Stone Age of southern Africa-the Still Bay and Howieson's Poort industries-that are associated with early evidence for symbols and personal ornaments. Establishing the correct sequence of events, however, has been hampered by inadequate chronologies. We report ages for nine sites from varied climatic and ecological zones across southern Africa that show that both industries were short-lived (5000 years or less), separated by about 7000 years, and coeval with genetic estimates of population expansion and exit times. Comparison with climatic records shows that these bursts of innovative behavior cannot be explained by environmental factors alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobs, Zenobia -- Roberts, Richard G -- Galbraith, Rex F -- Deacon, Hilary J -- Grun, Rainer -- Mackay, Alex -- Mitchell, Peter -- Vogelsang, Ralf -- Wadley, Lyn -- New York, N.Y. -- Science. 2008 Oct 31;322(5902):733-5. doi: 10.1126/science.1162219.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉GeoQuEST Research Centre, School of Earth and Environmental Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia. zenobia@uow.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18974351" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Southern ; *Anthropology, Physical ; *Archaeology ; Behavior ; Climate ; Culture ; Emigration and Immigration/history ; Geologic Sediments ; History, Ancient ; Humans ; Population Dynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2009-08-15
    Description: The controlled use of fire was a breakthrough adaptation in human evolution. It first provided heat and light and later allowed the physical properties of materials to be manipulated for the production of ceramics and metals. The analysis of tools at multiple sites shows that the source stone materials were systematically manipulated with fire to improve their flaking properties. Heat treatment predominates among silcrete tools at approximately 72 thousand years ago (ka) and appears as early as 164 ka at Pinnacle Point, on the south coast of South Africa. Heat treatment demands a sophisticated knowledge of fire and an elevated cognitive ability and appears at roughly the same time as widespread evidence for symbolic behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, Kyle S -- Marean, Curtis W -- Herries, Andy I R -- Jacobs, Zenobia -- Tribolo, Chantal -- Braun, David -- Roberts, David L -- Meyer, Michael C -- Bernatchez, Jocelyn -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):859-62. doi: 10.1126/science.1175028.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Archaeology, University of Cape Town, Rondebosch 7701, Cape Town, Republic of South Africa.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19679810" target="_blank"〉PubMed〈/a〉
    Keywords: *Archaeology ; Behavior ; *Fires ; History, Ancient ; *Hot Temperature ; Humans ; Paleontology ; South Africa ; Symbolism ; Technology/*history
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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