Publication Date:
2016-07-31
Description:
Two new indole alkaloid derivatives (1, 2), together with six known indole alkaloids (3-8) were isolated from the 70% ethanolic-H 2 O extract of the stem of Nauclea officinalis . Their structures were determined on the basis of extensive analyses of spectroscopic data (IR, MS, 1D and 2D NMR). All the isolates were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7, and all the compounds showed significant inhibitory activities with IC 50 values of 0.82, 6.45, 9.75, 1.34, 3.40, 2.69, 1.58, and 1.96 μM, compared to the positive drug control group aminoguanidine with IC 50 value of 1.80 μM, compound 1 had the most significant activity, especially. This article is protected by copyright. All rights reserved.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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