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  • 1
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    Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-21
    Description: The nucleotide exchange activity of RCC1, the only known nucleotide exchange factor for Ran, a Ras-like small guanosine triphosphatase, was required for microtubule aster formation with or without demembranated sperm in Xenopus egg extracts arrested in meiosis II. Consistently, in the RCC1-depleted egg extracts, Ran guanosine triphosphate (RanGTP), but not Ran guanosine diphosphate (RanGDP), induced self-organization of microtubule asters, and the process required the activity of dynein. Thus, Ran was shown to regulate formation of the microtubule network.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ohba, T -- Nakamura, M -- Nishitani, H -- Nishimoto, T -- New York, N.Y. -- Science. 1999 May 21;284(5418):1356-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi Higashi-ku, Fukuoka 812-8582, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10334990" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle Proteins ; Cell Extracts ; Cell Nucleus/metabolism ; DNA-Binding Proteins/metabolism ; Dyneins/metabolism ; Female ; GTP Phosphohydrolases/*metabolism ; *Guanine Nucleotide Exchange Factors ; Guanosine Diphosphate/metabolism ; Guanosine Triphosphate/*metabolism ; Male ; Microtubules/chemistry/*metabolism/ultrastructure ; Nuclear Proteins/analysis/*metabolism ; Ovum ; Recombinant Proteins/metabolism ; Sperm Head/physiology ; Spindle Apparatus/chemistry/*metabolism/ultrastructure ; Xenopus ; *Xenopus Proteins ; ran GTP-Binding Protein
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-09-18
    Description: Human cyclin E, originally identified on the basis of its ability to function as a G1 cyclin in budding yeast, associated with a cell cycle-regulated protein kinase in human cells. The cyclin E-associated kinase activity peaked during G1, before the appearance of cyclin A, and was diminished during exit from the cell cycle after differentiation or serum withdrawal. The major cyclin E-associated kinase in human cells was Cdk2 (cyclin-dependent kinase 2). The abundance of the cyclin E protein and the cyclin E-Cdk2 complex was maximal in G1 cells. These results provide further evidence that in all eukaryotes assembly of a cyclin-Cdk complex is an important step in the biochemical pathway that controls cell proliferation during G1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koff, A -- Giordano, A -- Desai, D -- Yamashita, K -- Harper, J W -- Elledge, S -- Nishimoto, T -- Morgan, D O -- Franza, B R -- Roberts, J M -- New York, N.Y. -- Science. 1992 Sep 18;257(5077):1689-94.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1388288" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/metabolism ; *CDC2-CDC28 Kinases ; Cell Line ; Cyclin-Dependent Kinase 2 ; *Cyclin-Dependent Kinases ; Cyclins/*metabolism ; Flow Cytometry ; G1 Phase/*physiology ; Humans ; Immunoblotting ; Immunosorbent Techniques ; Protein Kinases/*metabolism ; *Protein-Serine-Threonine Kinases ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Structural basis for eIF2B inhibition in integrated stress response (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉A core event in the integrated stress response, an adaptive pathway common to all eukaryotic cells in response to various stress stimuli, is the phosphorylation of eukaryotic translation initiation factor 2 (eIF2). Normally, unphosphorylated eIF2 transfers the methionylated initiator tRNA to the ribosome in a guanosine 5'-triphosphate–dependent manner. By contrast, phosphorylated eIF2 inhibits its specific guanine nucleotide exchange factor, eIF2B. To elucidate how the eIF2 phosphorylation status regulates the eIF2B activity, we determined cryo–electron microscopic and crystallographic structures of eIF2B in complex with unphosphorylated or phosphorylated eIF2. The unphosphorylated and phosphorylated forms of eIF2 bind to eIF2B in completely different manners: the nucleotide exchange-active and -inactive modes, respectively. These structures explain how phosphorylated eIF2 dominantly inhibits the nucleotide exchange activity of eIF2B.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Electronic Resource
    Electronic Resource
    Geochemical analyses of geological layers and groundwater flows (2000)
    Springer
    Environmental geology 39 (2000), S. 1147-1154 
    Details
    ISSN: 1432-0495
    Keywords: Key words Geological layers ; Groundwater flow ; X-ray fluorescent spectroscopy ; Chlorine element
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract X-ray fluorescent spectroscope analysis easily finds ratios of geochemical elements in soil. Applying the method of ratio matching to measured ratios, the classification of geological layers, and the flow directions of groundwater can be determined. This method is applied to three hill slopes in Japan and the results are in good agreement with the observations and measurements of soil cores obtained by drilling. The classification of geological layers is found to be quantitatively connected with the rates of organic matter in soil cores.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002549900086
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  • 5
    Electronic Resource
    Electronic Resource
    Prediction method of sand-movement direction in rivers by geochemical elements (1996)
    Springer
    Environmental geology 28 (1996), S. 88-98 
    Details
    ISSN: 1432-0495
    Keywords: Key words River sand ; Geochemical elements ; X-ray fluorescent spectroscopy ; Correlation number ; Ratio matching ; Correlation matrix ; Geological characteristics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  The analysis of sand samples by X-ray fluorescent spectroscopy (XRF) gives the ratio of the geochemical elements to construct the sand samples. The application of the ratio matching to sand samples represents the correlation number between two sand samples with respect to geochemical elements. When the correlation number between two sand samples is low, the two samples are not geochemically similar each other. This denotes that the exchange of sand between two sampling points is scarce or the two samples are independent. When the correlation number between two sand samples is high, the two samples are geochemically similar, signifying that the exchange of sand between two sampling points is frequent or there is sand movement between two sampling points. If there exists prominent sand movement in the study area, the correlation number is almost 1 and kilo count number per second of each geochemical element per weight decreases along the flow direction. The decrease is caused by the reduction of sizes and the adherence of dirt on the surface of sand particles. Since the flow direction in rivers is usually the same as the direction of sand movement, it can be verified. This study obtains satisfactory results applying the method of prediction in sand movement to sediments in rivers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540050081
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  • 6
    Electronic Resource
    Electronic Resource
    Prediction method of sand-movement direction in water by geochemical elements (1995)
    Springer
    Environmental geology 25 (1995), S. 100-108 
    Details
    ISSN: 1432-0495
    Keywords: Sand movement ; Geochemistry ; Fluorescent spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The analysis of sand samples by x-ray fluorescent spectroscopy (XRF) gives the ratio of the geochemical elements to construct the sand samples. The x-ray analysis therefore shows the geochemical characteristics of sand in the sampled area. In this study, sand is sampled on coasts and rivers of the Noto Peninsula to determine the geochemical elements and to show the geological characteristics that occur, especially iron and calcium. The experiments show the effect of rivers and Kotogahama beach on iron and calcium, respectively. Applying the method of ratio matching to the measured data of the geochemical elements, the direction of movement of sand on the coast is determined by considering the correlation matrix and the ratio of geochemical elements between sand samples at two locations. The predominant longshore direction movement of sand offshore in the study area is from south to north. Sand in rivers is not directly transported to adjacent beaches; however, offshore sand is transported to beaches. The estimated direction of movement of sand longshore near coastal structures agrees with observations. The proposed method to predict the direction of movement of sand gives the correct one in comparison with the observed data in rivers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00767865
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  • 7
    Electronic Resource
    Electronic Resource
    The gene coding a ubiquitin-activating enzyme may locate on X chromosome
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 153 (1988), S. 1173-1178 
    Details
    ISSN: 0006-291X
    Keywords: [abr] DME; Dulbecco modified Eagle medium ; [abr] HPRT; hypoxanthine phosphoribosyl transferase ; [abr] PCC; premature chromosome condensation ; [abr] PEG; polyethyleneglycol ; [abr] TK; thymidine kinase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(88)81351-2
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  • 8
    Electronic Resource
    Electronic Resource
    The correlation between transcription and membrane-association of λ DNA
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 46 (1972), S. 349-356 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(72)80145-1
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  • 9
    Electronic Resource
    Electronic Resource
    Molecular Cloning and Identification of Two Types of Hamster Cyclin-Dependent Kinases: CDK2 and CDK2L
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 197 (1993), S. 1524-1529 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bbrc.1993.2650
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  • 10
    Electronic Resource
    Electronic Resource
    The Human CHC1 Gene Encoding RCC1 (Regulator of Chromosome Condensation) (CHC1) Is Localized to Human Chromosome 1p36.1
    Amsterdam : Elsevier
    Genomics 23 (1994), S. 719-721 
    Details
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/geno.1994.1570
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