Publication Date:
1990-11-30
Description:
The current studies were designed to determine whether chronic overexpression of low density lipoprotein (LDL) receptors in the liver would protect mice from the increase in plasma LDL-cholesterol that is induced by high-fat diets. A line of transgenic mice was studied that express the human LDL receptor gene in the liver under control of the transferrin promoter. When fed a diet containing cholesterol, saturated fat, and bile acids for 3 weeks, the transgenic mice, in contrast to normal mice, did not develop a detectable increase in plasma LDL. The current data indicate that unregulated overexpression of LDL receptors can protect against diet-induced hypercholesterolemia in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yokode, M -- Hammer, R E -- Ishibashi, S -- Brown, M S -- Goldstein, J L -- HL 20948/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1990 Nov 30;250(4985):1273-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics, University of Texas, Southwestern Medical Center, Dallas 75235.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2244210" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cholesterol, Dietary/adverse effects
;
Cholesterol, LDL/*blood
;
Dietary Fats/*adverse effects
;
Exons
;
*Gene Expression
;
Humans
;
Hypercholesterolemia/etiology/*prevention & control
;
Introns
;
Lipoproteins/blood
;
Lipoproteins, HDL/blood
;
Lipoproteins, IDL
;
Lipoproteins, VLDL/blood
;
Liver/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Nucleic Acid Hybridization
;
Promoter Regions, Genetic/genetics
;
RNA, Messenger/genetics
;
Receptors, LDL/*genetics
;
Transferrin/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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