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  • 1
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    New 1222-Type Thallium-Indium Layered Cuprates (Tl,In)Sr 2 (Nd,Ce) 2 Cu 2 O z and Their Superconductivity (1993)
    Institute of Physics
    Details
    Publication Date: 1993-01-01
    Print ISSN: 0256-307X
    Electronic ISSN: 1741-3540
    Topics: Physics
    Published by Institute of Physics
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  • 2
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    Smart cities – enabling services and applications (2016)
    Springer
    Details
    Publication Date: 2016-06-23
    Print ISSN: 1867-4828
    Electronic ISSN: 1869-0238
    Topics: Computer Science
    Published by Springer
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  • 3
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    Future Internet, Vol. 11, Pages 70: Software-Defined Heterogeneous Vehicular Networking: The Architectural Design and Open Challenges (2019)
    MDPI
    Details
    Publication Date: 2019
    Description: The promising advancements in the telecommunications and automotive sectors over the years have empowered drivers with highly innovative communication and sensing capabilities, in turn paving the way for the next-generation connected and autonomous vehicles. Today, vehicles communicate wirelessly with other vehicles and vulnerable pedestrians in their immediate vicinity to share timely safety-critical information primarily for collision mitigation. Furthermore, vehicles connect with the traffic management entities via their supporting network infrastructure to become more aware of any potential hazards on the roads and for guidance pertinent to their current and anticipated speeds and travelling course to ensure more efficient traffic flows. Therefore, a secure and low-latency communication is highly indispensable in order to meet the stringent performance requirements of such safety-critical vehicular applications. However, the heterogeneity of diverse radio access technologies and inflexibility in their deployment results in network fragmentation and inefficient resource utilization, and these, therefore, act as bottlenecks in realizing the aims for a highly efficient vehicular networking architecture. In order to overcome such sorts of bottlenecks, this article brings forth the current state-of-the-art in the context of intelligent transportation systems (ITS) and subsequently proposes a software-defined heterogeneous vehicular networking (SDHVNet) architecture for ensuring a highly agile networking infrastructure to ensure rapid network innovation on-demand. Finally, a number of potential architectural challenges and their probable solutions are discussed.
    Electronic ISSN: 1999-5903
    Topics: Computer Science
    Published by MDPI
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  • 4
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    Tunable monoenergetic electron beams from independently controllable laser-wakefield acceleration and injection (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-01-06
    Description: Author(s): G. Golovin, S. Chen, N. Powers, C. Liu, S. Banerjee, J. Zhang, M. Zeng, Z. Sheng, and D. Umstadter We report the results of experiments on laser-wakefield acceleration in a novel two-stage gas target with independently adjustable density and atomic-composition profiles. We were able to tailor these profiles in a way that led to the separation of the processes of electron injection and acceleratio... [Phys. Rev. ST Accel. Beams 18, 011301] Published Mon Jan 05, 2015
    Keywords: New Acceleration Techniques
    Electronic ISSN: 1098-4402
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5 (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-15
    Description: The mammalian hippocampus contains the neural circuitry that is crucial for cognitive functions such as learning and memory. The development of such circuitry is dependent on the generation and correct placement of the appropriate number and types of neurons. Mice lacking function of the LIM homeobox gene Lhx5 showed a defect in hippocampus development. Hippocampal neural precursor cells were specified and proliferated, but many of them failed to either exit the cell cycle or to differentiate and migrate properly. Lhx5 is therefore essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhao, Y -- Sheng, H Z -- Amini, R -- Grinberg, A -- Lee, E -- Huang, S -- Taira, M -- Westphal, H -- New York, N.Y. -- Science. 1999 May 14;284(5417):1155-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10325223" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Patterning ; Cell Differentiation ; Cell Division ; Cell Movement ; Crosses, Genetic ; Dentate Gyrus/cytology/embryology ; Female ; Gene Deletion ; Gene Expression ; *Genes, Homeobox ; Hippocampus/*cytology/*embryology ; Homeodomain Proteins/*genetics/physiology ; Interneurons/cytology ; LIM-Homeodomain Proteins ; Male ; Mice ; Morphogenesis ; Nerve Tissue Proteins/*genetics/physiology ; Neuroglia/cytology ; Neurons/*cytology ; Pyramidal Cells/cytology ; Stem Cells/*cytology ; Transcription Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Multistep control of pituitary organogenesis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps-first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sheng, H Z -- Moriyama, K -- Yamashita, T -- Li, H -- Potter, S S -- Mahon, K A -- Westphal, H -- New York, N.Y. -- Science. 1997 Dec 5;278(5344):1809-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9388186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Division ; Cell Lineage ; Embryonic and Fetal Development/genetics ; Gene Expression Regulation, Developmental ; *Genes, Homeobox ; Homeodomain Proteins/*genetics/physiology ; LIM-Homeodomain Proteins ; Mice ; Mutation ; Pituitary Gland/chemistry/cytology/*embryology ; Pituitary Hormones/analysis/genetics ; Stem Cells/cytology ; *Transcription Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Specification of pituitary cell lineages by the LIM homeobox gene Lhx3 (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-17
    Description: During pituitary organogenesis, the progressive differentiation of distinct pituitary-specific cell lineages from a common primordium involves a series of developmental decisions and inductive interactions. Targeted gene disruption in mice showed that Lhx3, a LIM homeobox gene expressed in the pituitary throughout development, is essential for differentiation and proliferation of pituitary cell lineages. In mice homozygous for the Lhx3 mutation, Rathke's pouch formed but failed to grow and differentiate; such mice lacked both the anterior and intermediate lobes of the pituitary. The determination of all pituitary cell lineages, except the corticotrophs, was affected, suggesting that a distinct, Lhx3-independent ontogenetic pathway exists for the initial specification of this lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sheng, H Z -- Zhadanov, A B -- Mosinger, B Jr -- Fujii, T -- Bertuzzi, S -- Grinberg, A -- Lee, E J -- Huang, S P -- Mahon, K A -- Westphal, H -- New York, N.Y. -- Science. 1996 May 17;272(5264):1004-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638120" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carrier Proteins/genetics ; Cell Differentiation ; Cell Lineage ; Embryonic and Fetal Development ; *Gene Expression Regulation, Developmental ; Gene Targeting ; *Genes, Homeobox ; Glycoprotein Hormones, alpha Subunit/biosynthesis/genetics ; Homeodomain Proteins/*genetics ; LIM-Homeodomain Proteins ; *Membrane Proteins ; Mice ; Mutation ; Phospholipid Transfer Proteins ; Pituitary Gland/abnormalities/*cytology/embryology ; Pituitary Gland, Anterior/abnormalities/*cytology/embryology ; Pro-Opiomelanocortin/biosynthesis/genetics ; Transcription Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-06-03
    Description: The low density lipoprotein receptor-related protein (LRP) has been proposed to mediate in concert with the LDL receptor (LDLR) the uptake of dietary lipoproteins into the hepatocytes. This hypothesis was tested by transient inactivation of LRP in vivo. Receptor-associated protein (RAP), a dominant negative regulator of LRP function, was transferred by an adenoviral vector to the livers of mice lacking LDLR (LDLR-/-). The inactivation of LRP by RAP was associated with a marked accumulation of chylomicron remnants in LDLR-/- mice and to a lesser degree in normal mice, suggesting that both LDLR and LRP are involved in remnant clearance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willnow, T E -- Sheng, Z -- Ishibashi, S -- Herz, J -- HL20948/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1994 Jun 3;264(5164):1471-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7515194" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviridae/genetics ; Animals ; Apolipoprotein B-48 ; Apolipoproteins B/*metabolism ; Carrier Proteins/genetics/*physiology ; Cholesterol/blood ; Chylomicrons/blood/*metabolism ; Gene Transfer Techniques ; Genetic Vectors ; Glycoproteins/genetics/*physiology ; LDL-Receptor Related Protein-Associated Protein ; Liver/*metabolism ; Low Density Lipoprotein Receptor-Related Protein-1 ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Immunologic/antagonists & inhibitors/*metabolism ; Receptors, LDL/metabolism ; Triglycerides/blood ; alpha-Macroglobulins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents (2018)
    Royal Society
    Details
    Publication Date: 2018-07-05
    Description: Metastatic cancer is considered a fatal progression of cancer worldwide. It has been shown that a key player in this scenario is the CXC chemokine receptor 2 (CXCR2). To identify novel CXCR2 antagonists, a pharmacophore model was built with the H ip H op program by screening a database containing compounds which were designed based on the known structure–activity relationship (SAR) of the diarylurea series CXCR2 antagonists. Compound 1a bearing the novel skeleton was selected from database screening and subjected to the in vitro biological test which showed a moderate CXCR2 antagonist potential. With further modification and exploration of SAR, compound 1e demonstrated improved CXCR2 antagonist activity with an IC 50 value of 14.8 µM. Furthermore, wound healing assay using the NCI-H1299 cell line indicated that 1e showed an excellent anti-cancer metastatic effect (72% inhibition in cell migration at 50 µg ml –1 ).
    Keywords: medicinal chemistry, computer-aided design
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 10
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    Bandgap control for the lattice-matched InGaAs/InAlAs/InP single quantum wells (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-02-14
    Description: In 0.53 Ga 0.47 As/In 0.52 Al 0.48 As single quantum well (SQW) grown by molecular-beam epitaxy on the InP (001) substrate is investigated by using photoluminescence (PL) spectroscopy and time-resolved photoluminescence (TRPL). At the low temperature of 8 K and excitation intensity of 1 W/cm 2 , the emitting wavelength of QWs shifts from 1387 nm to 1537 nm when the well width increases from 5 nm to 50 nm, approaching the emitting wavelength of bulk In 0.52 Al 0.48 As. The emitting wavelength of QWs can be flexibly tailored by varying the thickness of the InGaAs layer.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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