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  • 1
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    Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-11-22
    Description: Fatty acid binding proteins (FABPs) are small cytoplasmic proteins that are expressed in a highly tissue-specific manner and bind to fatty acids such as oleic and retinoic acid. Mice with a null mutation in aP2, the gene encoding the adipocyte FABP, were developmentally and metabolically normal. The aP2-deficient mice developed dietary obesity but, unlike control mice, they did not develop insulin resistance or diabetes. Also unlike their obese wild-type counterparts, obese aP2-/- animals failed to express in adipose tissue tumor necrosis factor-alpha (TNF-alpha), a molecule implicated in obesity-related insulin resistance. These results indicate that aP2 is central to the pathway that links obesity to insulin resistance, possibly by linking fatty acid metabolism to expression of TNF-alpha.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hotamisligil, G S -- Johnson, R S -- Distel, R J -- Ellis, R -- Papaioannou, V E -- Spiegelman, B M -- DK31405/DK/NIDDK NIH HHS/ -- HD27295/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 22;274(5291):1377-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8910278" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/*metabolism ; Animals ; Blood Glucose/metabolism ; Carrier Proteins/genetics/metabolism/*physiology ; Dietary Fats/administration & dosage ; Fatty Acid-Binding Proteins ; Fatty Acids/*metabolism ; Female ; Gene Expression Regulation ; Gene Targeting ; Glucose Tolerance Test ; Homeostasis ; Insulin/blood ; *Insulin Resistance ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Myelin P2 Protein/genetics/metabolism/*physiology ; *Neoplasm Proteins ; *Nerve Tissue Proteins ; Obesity/*metabolism ; Triglycerides/blood ; Tumor Necrosis Factor-alpha/*biosynthesis/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Haploid expression of a mouse testis alpha-tubulin gene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-06
    Description: A complementary DNA clone for an alpha-tubulin has been isolated from a mouse testis complementary DNA library. The untranslated 3' end of this complementary DNA is homologous to two RNA transcripts present in postmeiotic cells of the testis but absent from meiotic cells and from several tissues including brain. The temporal expression of this alpha-tubulin complementary DNA provides evidence for the haploid expression of a mammalian structural gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Distel, R J -- Kleene, K C -- Hecht, N B -- GM 29224/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):68-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701535" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/metabolism ; Cloning, Molecular ; DNA/genetics ; Drosophila ; Gene Expression Regulation ; Haploidy ; Male ; Mice ; Nucleic Acid Hybridization ; Rats ; Spermatids/metabolism ; Spermatogenesis ; Spermatozoa/physiology ; Testis/*metabolism ; Tubulin/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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