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  • 1
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    Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1 (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-03-21
    Description: The sphingolipid metabolite sphingosine-1-phosphate (SPP) has been implicated as a second messenger in cell proliferation and survival. However, many of its biological effects are due to binding to unidentified receptors on the cell surface. SPP activated the heterotrimeric guanine nucleotide binding protein (G protein)-coupled orphan receptor EDG-1, originally cloned as Endothelial Differentiation Gene-1. EDG-1 bound SPP with high affinity (dissociation constant = 8.1 nM) and high specificity. Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, M J -- Van Brocklyn, J R -- Thangada, S -- Liu, C H -- Hand, A R -- Menzeleev, R -- Spiegel, S -- Hla, T -- DK45659/DK/NIDDK NIH HHS/ -- GM43880/GM/NIGMS NIH HHS/ -- HL49094/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1998 Mar 6;279(5356):1552-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Connecticut School of Medicine, Farmington, CT 06030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9488656" target="_blank"〉PubMed〈/a〉
    Keywords: Cadherins/*biosynthesis ; *Cell Aggregation ; Cell Differentiation ; Cell Line ; Cloning, Molecular ; GTP-Binding Proteins/metabolism ; Gene Expression ; Genes, Immediate-Early ; Humans ; Immediate-Early Proteins/genetics/*metabolism ; Intercellular Junctions/*ultrastructure ; Ligands ; *Lysophospholipids ; Mitogen-Activated Protein Kinase 1/metabolism ; Morphogenesis ; Receptors, Cell Surface/genetics/*metabolism ; *Receptors, G-Protein-Coupled ; Receptors, Lysophospholipid ; Signal Transduction ; Sphingosine/*analogs & derivatives/metabolism ; Transfection ; rho GTP-Binding Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    On and off retinal circuit assembly by divergent molecular mechanisms (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-02
    Description: Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and normal SAC stratification in the mouse retina. Plexin A2 is expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs. Specific On-Off bistratified direction-selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of On directional motion responses. These results correlate the elaboration of symmetric SAC dendritic morphology and asymmetric responses to motion, shedding light on the development of visual pathways that use the same cell types for divergent outputs.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863450/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863450/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Lu O -- Jiang, Zheng -- Rivlin-Etzion, Michal -- Hand, Randal -- Brady, Colleen M -- Matsuoka, Ryota L -- Yau, King-Wai -- Feller, Marla B -- Kolodkin, Alex L -- EY013528/EY/NEI NIH HHS/ -- EY019498/EY/NEI NIH HHS/ -- EY06837/EY/NEI NIH HHS/ -- NS35165/NS/NINDS NIH HHS/ -- P30 NS050274/NS/NINDS NIH HHS/ -- R01 EY006837/EY/NEI NIH HHS/ -- R01 EY019498/EY/NEI NIH HHS/ -- R01 NS035165/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):1241974. doi: 10.1126/science.1241974.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24179230" target="_blank"〉PubMed〈/a〉
    Keywords: Amacrine Cells/cytology/metabolism/*physiology ; Animals ; Dendrites/metabolism/physiology ; Mice ; Mice, Mutant Strains ; Motion ; *Motion Perception ; Nerve Tissue Proteins/genetics/*metabolism ; Receptors, Cell Surface/genetics/*metabolism ; Retina/metabolism/*physiology ; Semaphorins/genetics/*metabolism ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Viscosity of Clay Suspensions (1938)
    [s.l.] : Nature Publishing Group
    Nature 142 (1938), S. 255-255 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] CONSIDERABLE attention has been given recently to the thixotropy and viscosity characteristics of clays. During the course of a research programme now in progress, certain results of general interest have been obtained. Average Yield Value Fract. No. equivalent Mobility 25° ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/142255a0
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  • 4
    Electronic Resource
    Electronic Resource
    The use of agarose gel electrophoresis to measure the size of DNA molecules in crude cell lysates
    Amsterdam : Elsevier
    Analytical Biochemistry 115 (1981), S. 231-235 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(81)90551-0
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  • 5
    Electronic Resource
    Electronic Resource
    Electrical stunning and stillness of lambs
    Amsterdam : Elsevier
    Meat Science 11 (1984), S. 45-58 
    Details
    ISSN: 0309-1740
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0309-1740(84)90016-0
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  • 6
    Electronic Resource
    Electronic Resource
    Studies on triploid oysters in Australia: effect of initial size on growth of diploid and triploid Sydney rock oysters, Saccostrea commercialis (Iredale & Roughley) (1999)
    Oxford, UK : Blackwell Science Ltd
    Aquaculture research 30 (1999), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: In a 2-year grow-out trial, triploid Sydney rock oysters, Saccostrea commercialis (Iredale & Roughley), from two initial size grades grew faster (in terms of both mean whole weight and shell height) than the equivalent initial size grades of sibling diploids (P 〈 0.05). Small size grade triploids caught up with and had significantly heavier (P 〈 0.05) final whole weights than large size grade diploids after a 2-years grow-out period. The initial size grade had a significant effect on final mean whole weight and shell height for both ploidy types. After the 2-years grow-out trial, the final mean whole weights (but not shell heights) of small and large diploids (35.8 ± 0.6 g and 39.4 ± 0.5 g, respectively) were significantly different (P 〈 0.05). Small and large triploids grew at a similar rate for the first 18 months despite the significantly (P 〈 0.05) heavier final mean weight of large grade triploids (48.4 ± 0.8 g and 61.2 ± 0.7 g, respectively). The effect of the initial size grade on subsequent growth of both diploid and triploid oysters which was demonstrated in the present study is of significant commercial value to hatchery and nursery operators as well as growers of single seed oysters. In addition, small-grade triploids appeared to be more valuable in terms of potential growth rate than all diploid grades. There was no significant difference in the final percentage triploidy between small and large grade triploids. A large proportion of diploid/triploid mosaicism was detected in adult oysters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2109.1999.00296.x
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  • 7
    Electronic Resource
    Electronic Resource
    The use of liquid jets to simulate angled drop impact (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 70 (1991), S. 7111-7118 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The liquid jet impact technique has been used extensively for the quantitative study of rain impact. Most of this work has been for normal impact. Although some angled impact studies have been pursued using jets, these have been purely of a qualitative nature. This paper develops the theory of angled drop impact. This allows the establishment of a method of correlating between angled drop and jet impact and obtaining "equivalent drop'' curves for jet impact. The correlation is also applied to normal impact. For normal impact it is shown that the previously published equivalent drop curves need to be modified especially at low velocities. The results for both normal and angled impact are discussed with reference to the details of the jet profile, and it is shown that angled jets may be considered as having an average equivalent drop size. The theory of angled impact also explains the shape of damage marks produced by impact and why the amount of damage decreases so rapidly with increasing angle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.349793
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  • 8
    Electronic Resource
    Electronic Resource
    Inhibition of mammalian DNA replication by dichlorobenzimidazole riboside
    Amsterdam : Elsevier
    Experimental Cell Research 107 (1977), S. 343-354 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(77)90356-1
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  • 9
    Electronic Resource
    Electronic Resource
    DNA replication during a serum-induced S phase in primate CV-1 cells
    Amsterdam : Elsevier
    Experimental Cell Research 121 (1979), S. 363-371 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(79)90016-8
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  • 10
    Electronic Resource
    Electronic Resource
    Further characterization of the phenotype of ts20, a DNA^t^s mutant of BALB/3T3 cells
    Amsterdam : Elsevier
    Experimental Cell Research 160 (1985), S. 184-196 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(85)90247-2
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