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  • 1
    Publication Date: 2013-05-08
    Description: MicroRNA-122 (miR-122) facilitates hepatitis C virus replication in vitro. Serum miR-122 has been implicated as a biomarker for various liver diseases; however, its role in chronic hepatitis C remains unclear. To address this issue, 126 patients with chronic hepatitis C who completed pegylated IFN plus ribavirin therapy with sustained virologic...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2015-06-10
    Description: Signal transducer and activator of transcription 3 (STAT3) had been involved in liver fibrogenesis. We aimed to explore the antifibrotic activities of sorafenib and its derivative SC-1 (devoid of Raf kinase inhibition activity) both in vivo and in vitro with special focus on the STAT3 pathway in hepatic stellate cells...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 3
    Publication Date: 2012-06-29
    Description: The global ionospheric response to a stratospheric sudden warming (SSW) is studied using three-dimensional electron density maps derived from radio occultation observations of FORMOSAT-3/COSMIC during the 2009 SSW periods. Results show that the ionospheric electron density at EIA crests exhibit a morning/early afternoon increase followed by an afternoon decrease and an evening increase, indicative of a semidiurnal component during the SSW period, which is consistent with recent studies. The latitude-altitude electron density slice maps show that the SSW related modifications of the equatorial plasma fountain interact with the existing summer-to-winter neutral winds and resulting in a north–south asymmetry. The global ionospheric response shows a clear longitudinal dependence in the equatorial plasma fountain enhancement during morning/early afternoon, inferred from the duration of the equatorial ionization anomaly (EIA) enhancement. Following the enhancement, prominent global EIA reductions resulting from the equatorial plasma fountain weakening in the afternoon sector are seen. The ionospheric response to the 2009 SSW event is also compared with the usual seasonal variation during January–February 2007. Instead of showing the electron density increase in the northern hemisphere and decrease in the southern hemisphere as the usual seasonal variation does, the SSW period ionosphere shows prominent global electron density reductions in the afternoon period during the 2009 SSW event.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 4
    Publication Date: 2011-09-16
    Description: Author(s): L. Liu, C. H. Liu, J. G. Wang, and R. K. Janev State-selective and total single-electron-capture cross sections in collisions of H + with the excited Li * (2 p ) atom have been investigated by using the full quantum-mechanical molecular orbital close-coupling (QMOCC) method in the energy range 0.001–3 keV/u and by the two-center atomic orbital close-... [Phys. Rev. A 84, 032710] Published Thu Sep 15, 2011
    Keywords: Atomic and molecular collisions and interactions
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
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  • 5
    Publication Date: 2015-01-15
    Description: A new class of complex nonsymmetric algebraic Riccati equations has been studied by Liu & Xue (2012. Complex nonsymmetric algebraic Riccati equations arising in Markov modulated fluid flows. SIAM J. Matrix Anal. Appl. , 33 , 569–596), which is related to the M -matrix algebraic Riccati equations. Doubling algorithms, with properly chosen parameters, are used there for equations in this new class. It is pointed out that the number of iterations for the doubling algorithms may be relatively large in some situations. In this paper, we show that the performance of the doubling algorithms can often be improved significantly if a proper preprocessing procedure is used on the given Riccati equation. There are some difficult cases for which the preprocessing procedure does not help much by itself. We then propose new strategies for choosing parameters for doubling algorithms after using the preprocessing procedure. Numerical experiments show that our preprocessing procedure and the new parameter strategies are very effective.
    Print ISSN: 0272-4979
    Electronic ISSN: 1464-3642
    Topics: Mathematics
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  • 6
    Publication Date: 2012-09-07
    Description: A coincident observation that occurred on 24 March 2000 between the irregularity structure measured by ROCSAT-1 and the scintillation experiment at the Ascension Island has been studied. The study of scintillation statistics is carried out first, and the results show that the Nakagami distribution can portray the normalized intensity of the L-band scintillation at various S4 values, up to S4 equal to 1.4. Moreover, the departure of frequency dependence on S4 predicted by the weak scintillation is noticed due to multiple forward scattering effects. The coincident feature between the characteristics of irregularity structure and the scintillation variation are then studied. The causal relationship between the fluctuation of ion density and the scintillation variation is obtained. A numerical simulation using the parabolic wave equation has been carried out with the ROCSAT-1 data in space to compare with the ground scintillation observation. The results show the reasonable scintillation level at the coincident time to indicate a direct relationship between the irregularity structure and the scintillation in both temporal and amplitudinal variations. Finally, some assumptions and limitations of the simulation model are discussed.
    Print ISSN: 0048-6604
    Electronic ISSN: 1944-799X
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
    Publication Date: 2015-08-14
    Description: Ultrafast energy relaxation process in Bi 2 Te 3 thin films is studied using a collinear two color pump-probe technique. The coherent optical phonon is enhanced and destroyed by changing the separation times of double pump pulses. The non-oscillatory component of the reflectivity trace after the second pump pulse shows a distinct difference with and without the presence of coherent optical phonons, thus providing a direct evidence of the effect of optical phonon on the hot carrier relaxation process. The deduced characteristic times are systematically smaller when coherent optical phonons are involved in the energy transfer process. Comparatively, the conventional relaxation process is relatively slow, which is explained by the screening effect of the incoherent optical phonon. This work suggests that the energy relaxation can be manipulated through the excitation of coherent optical phonons.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 8
    Publication Date: 2012-04-27
    Description: Author(s): C. H. Liu, J. G. Wang, and R. K. Janev Dynamics of electron capture and excitation processes in collisions of H + with the excited He(2  1,3  L m ) atom ( L   =   S , P ) has been studied by using the full quantum-mechanical molecular orbital close-coupling (QMOCC) method with ab initio determined molecular states. 38 singlet and 37 triplet molecular... [Phys. Rev. A 85, 042719] Published Thu Apr 26, 2012
    Keywords: Atomic and molecular collisions and interactions
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
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  • 9
    Publication Date: 2012-01-19
    Description: In this paper, modifications of the ionospheric tidal signatures during the 2009 stratospheric sudden warming (SSW) event are studied by applying atmospheric tidal analysis to ionospheric electron densities observed using radio occultation soundings of FORMOSAT-3/COSMIC. The tidal analysis indicates that the zonal mean and major migrating tidal components (DW1, SW2 and TW3) decrease around the time of the SSW, with 1.5–4 hour time shifts in the daily time of maximum around EIA and middle latitudes. The typical ionospheric SSW signature: a semi-diurnal variation of the ionospheric electron density, featuring an earlier commencement and subsidence of EIA, can be reproduced by differencing the migrating tides before and during the SSW period. Our results also indicate that the migrating tides represent ∼80% of the ionospheric tidal components at specific longitudes, suggesting that modifications of the migrating tides may be the major driver for producing ionospheric changes observed during SSW events, accounting for greater variability than the nonmigrating tides that have been the focus of previous studies.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 10
    Publication Date: 2014-10-01
    Description: As described in a previous paper [ Tsai et al ., 2009], a three-dimensional ionospheric electron density ( N e ) model has been constructed from vertical N e profiles retrieved from the FS3/COSMIC GPS radio occultation (RO) measurements and worldwide ionosonde foF2 and foE data, and named the TaiWan Ionospheric Model (TWIM). The TWIM exhibits vertically fitted α-Chapman-type layers with distinct F2, F1, E, and D layers, and surface spherical harmonic approaches for the fitted layer parameters including peak density, peak density height and scale height. To improve the TWIM into a real-time model we have developed a time series autoregressive model to forecast short-term TWIM coefficients. The time series of TWIM coefficients are considered as realizations of stationary stochastic processes within a processing window of 30 days. These autocorrelation coefficients are used to derive the autoregressive parameters and then forecast the TWIM coefficients, based on the least squares method and Lagrange multiplier technique. The forecast root-mean-square relative TWIM coefficient errors are generally 〈30% for one day predictions. The forecast TWIM values of foE and foF2 values are also compared and evaluated using worldwide ionosonde data.
    Print ISSN: 0048-6604
    Electronic ISSN: 1944-799X
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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