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  • 1
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    Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-25
    Description: Long-term potentiation (LTP) at the Schaffer collateral-CA1 synapse involves interacting signaling components, including calcium (Ca2+)/calmodulin-dependent protein kinase II (CaMKII) and cyclic adenosine monophosphate (cAMP) pathways. Postsynaptic injection of thiophosphorylated inhibitor-1 protein, a specific inhibitor of protein phosphatase-1 (PP1), substituted for cAMP pathway activation in LTP. Stimulation that induced LTP triggered cAMP-dependent phosphorylation of endogenous inhibitor-1 and a decrease in PP1 activity. This stimulation also increased phosphorylation of CaMKII at Thr286 and Ca2+-independent CaMKII activity in a cAMP-dependent manner. The blockade of LTP by a CaMKII inhibitor was not overcome by thiophosphorylated inhibitor-1. Thus, the cAMP pathway uses PP1 to gate CaMKII signaling in LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blitzer, R D -- Connor, J H -- Brown, G P -- Wong, T -- Shenolikar, S -- Iyengar, R -- Landau, E M -- DK52054/DK/NIDDK NIH HHS/ -- GM54508/GM/NIGMS NIH HHS/ -- NS33646/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1998 Jun 19;280(5371):1940-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bronx VA Medical Center and Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA. rb2@doc.mssm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9632393" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors/*metabolism ; *Carrier Proteins ; Cyclic AMP/analogs & derivatives/*metabolism/pharmacology ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Electric Stimulation ; Enzyme Inhibitors/metabolism/pharmacology ; Hippocampus/*metabolism ; In Vitro Techniques ; *Intracellular Signaling Peptides and Proteins ; *Long-Term Potentiation ; Male ; Phosphoprotein Phosphatases/antagonists & inhibitors/*metabolism ; Phosphorylation ; Protein Phosphatase 1 ; RNA-Binding Proteins/metabolism/pharmacology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Synapses/*metabolism ; Thionucleotides/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Formation of regulatory patterns during signal propagation in a Mammalian cellular network (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-08-16
    Description: We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity were highly connected nodes required for the formation of regulatory motifs, indicating the potential importance of such motifs in determining cellular choices between homeostasis and plasticity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032439/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032439/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ma'ayan, Avi -- Jenkins, Sherry L -- Neves, Susana -- Hasseldine, Anthony -- Grace, Elizabeth -- Dubin-Thaler, Benjamin -- Eungdamrong, Narat J -- Weng, Gehzi -- Ram, Prahlad T -- Rice, J Jeremy -- Kershenbaum, Aaron -- Stolovitzky, Gustavo A -- Blitzer, Robert D -- Iyengar, Ravi -- DA15863/DA/NIDA NIH HHS/ -- GM-072853/GM/NIGMS NIH HHS/ -- GM-54508/GM/NIGMS NIH HHS/ -- GM-62754/GM/NIGMS NIH HHS/ -- GM-65065/GM/NIGMS NIH HHS/ -- P50 GM071558/GM/NIGMS NIH HHS/ -- P50 GM071558-01A20007/GM/NIGMS NIH HHS/ -- P50 GM071558-020007/GM/NIGMS NIH HHS/ -- P50 GM071558-030007/GM/NIGMS NIH HHS/ -- R01 GM054508/GM/NIGMS NIH HHS/ -- R01 GM054508-12/GM/NIGMS NIH HHS/ -- R01 GM072853/GM/NIGMS NIH HHS/ -- R01 GM072853-01/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 12;309(5737):1078-83.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Biological Chemistry Mount Sinai School of Medicine, New York, NY 10029, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16099987" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Feedback, Physiological ; Glutamic Acid/metabolism ; Hippocampus/*cytology/physiology ; Homeostasis ; Ligands ; Long-Term Potentiation ; Mammals ; Mathematics ; Mitogen-Activated Protein Kinases/metabolism ; Models, Neurological ; Neuronal Plasticity ; Neurons/*physiology ; Norepinephrine/metabolism ; Protein Kinase C/metabolism ; Receptors, AMPA/metabolism ; *Signal Transduction ; Software ; Systems Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A critical role for IGF-II in memory consolidation and enhancement (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-01-29
    Description: We report that, in the rat, administering insulin-like growth factor II (IGF-II, also known as IGF2) significantly enhances memory retention and prevents forgetting. Inhibitory avoidance learning leads to an increase in hippocampal expression of IGF-II, which requires the transcription factor CCAAT enhancer binding protein beta and is essential for memory consolidation. Furthermore, injections of recombinant IGF-II into the hippocampus after either training or memory retrieval significantly enhance memory retention and prevent forgetting. To be effective, IGF-II needs to be administered within a sensitive period of memory consolidation. IGF-II-dependent memory enhancement requires IGF-II receptors, new protein synthesis, the function of activity-regulated cytoskeletal-associated protein and glycogen-synthase kinase 3 (GSK3). Moreover, it correlates with a significant activation of synaptic GSK3beta and increased expression of GluR1 (also known as GRIA1) alpha-amino-3-hydroxy-5-methyl-4-isoxasolepropionic acid receptor subunits. In hippocampal slices, IGF-II promotes IGF-II receptor-dependent, persistent long-term potentiation after weak synaptic stimulation. Thus, IGF-II may represent a novel target for cognitive enhancement therapies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908455/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908455/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Dillon Y -- Stern, Sarah A -- Garcia-Osta, Ana -- Saunier-Rebori, Bernadette -- Pollonini, Gabriella -- Bambah-Mukku, Dhananjay -- Blitzer, Robert D -- Alberini, Cristina M -- F31-MH816213/MH/NIMH NIH HHS/ -- R01 MH065635/MH/NIMH NIH HHS/ -- R01 MH074736/MH/NIMH NIH HHS/ -- R01-GM054508/GM/NIGMS NIH HHS/ -- R01-MH065635/MH/NIMH NIH HHS/ -- R01-MH074736/MH/NIMH NIH HHS/ -- R21-DA29298/DA/NIDA NIH HHS/ -- T32 MH087004/MH/NIMH NIH HHS/ -- T32-MH087004/MH/NIMH NIH HHS/ -- England -- Nature. 2011 Jan 27;469(7331):491-7. doi: 10.1038/nature09667.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21270887" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CCAAT-Enhancer-Binding Protein-beta/metabolism ; Gene Expression Regulation ; Hippocampus/drug effects/*metabolism ; Insulin-Like Growth Factor II/*metabolism/pharmacology ; Long-Term Potentiation/physiology ; Male ; Memory/drug effects/*physiology ; Rats ; Rats, Long-Evans ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Ligand-Gated Ion Channels (2005)
    American Association for the Advancement of Science
    Details
    Publication Date: 2005-04-12
    Print ISSN: 1945-0877
    Electronic ISSN: 1937-9145
    Topics: Biology , Medicine
    Published by American Association for the Advancement of Science
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  • 5
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    Long-Term Potentiation: Mechanisms of Induction and Maintenance (2005)
    American Association for the Advancement of Science
    Details
    Publication Date: 2005-11-01
    Print ISSN: 1945-0877
    Electronic ISSN: 1937-9145
    Topics: Biology , Medicine
    Published by American Association for the Advancement of Science
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  • 6
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    Synthesis and Structure−Activity Relationships of N-Propyl-N-(4-pyridinyl)-1H-indol-1-amine (Besipirdine) and Related Analogs as Potential Therapeutic Agents for Alzheimer's Disease (1996)
    American Chemical Society
    Details
    Publication Date: 1996-01-01
    Print ISSN: 0022-2623
    Electronic ISSN: 1520-4804
    Topics: Chemistry and Pharmacology , Medicine
    Published by American Chemical Society
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