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  • 1
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    A Synchrotron X-ray Study of a Solid-Solid Phase Transition in a Two-Dimensional Crystal (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-12-02
    Description: A measurement and interpretation on a molecular level of a phase transition in an ordered Langmuir monolayer is reported. The diagram of surface pressure (pi) versus molecular area of a monolayer of chiral (S)-[CF(3)-(CF(2))(9)-(CH(2))(2)-OCO-CH(2)-CH (NH(3)(+))CO(2)(-)] over water shows a change in slope at about pi(s)= 25 millinewtons per meter. Grazing-incidence x-ray diffraction and specular reflectivity measurements indicate a solid-solid phase transition at pi(s). The diffraction pattren at low pressures reveals two diffraction peaks of equal intensities, with lattice spacings d of 5.11 and 5.00 angstroms; these coalesce for pi 〉/=pi(s). Structural models that fit the diffraction data show that at pi〉 pi(s) the molecules pack in a two-dimensional crystal with the molecules aligned vertically. At pi 〈 pi(s) there is a molecular tilt of 16 degrees +/- 7 degrees . Independent x-ray reflectivity data yield a tilt of 26 degrees +/- 7 degrees . Concomitant with the tilt, the diffraction data indicate a transition from a hexagonal to a distorted-hexagonal lattice. The hexagonal arrangement is favored because the -(CF(2))(9)CF(3) moiety adopts a helical conformation. Compression to 70 millinewtons per meter yields a unit cell with increased crystallinity and a coherence length exceeding 1000 angstroms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolf, S G -- Landau, E M -- Lahav, M -- Leiserowitz, L -- Deutsch, M -- Kjaer, K -- Als-Nielsen, J -- New York, N.Y. -- Science. 1988 Dec 2;242(4883):1286-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17817076" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-25
    Description: Long-term potentiation (LTP) at the Schaffer collateral-CA1 synapse involves interacting signaling components, including calcium (Ca2+)/calmodulin-dependent protein kinase II (CaMKII) and cyclic adenosine monophosphate (cAMP) pathways. Postsynaptic injection of thiophosphorylated inhibitor-1 protein, a specific inhibitor of protein phosphatase-1 (PP1), substituted for cAMP pathway activation in LTP. Stimulation that induced LTP triggered cAMP-dependent phosphorylation of endogenous inhibitor-1 and a decrease in PP1 activity. This stimulation also increased phosphorylation of CaMKII at Thr286 and Ca2+-independent CaMKII activity in a cAMP-dependent manner. The blockade of LTP by a CaMKII inhibitor was not overcome by thiophosphorylated inhibitor-1. Thus, the cAMP pathway uses PP1 to gate CaMKII signaling in LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blitzer, R D -- Connor, J H -- Brown, G P -- Wong, T -- Shenolikar, S -- Iyengar, R -- Landau, E M -- DK52054/DK/NIDDK NIH HHS/ -- GM54508/GM/NIGMS NIH HHS/ -- NS33646/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1998 Jun 19;280(5371):1940-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bronx VA Medical Center and Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA. rb2@doc.mssm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9632393" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors/*metabolism ; *Carrier Proteins ; Cyclic AMP/analogs & derivatives/*metabolism/pharmacology ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Electric Stimulation ; Enzyme Inhibitors/metabolism/pharmacology ; Hippocampus/*metabolism ; In Vitro Techniques ; *Intracellular Signaling Peptides and Proteins ; *Long-Term Potentiation ; Male ; Phosphoprotein Phosphatases/antagonists & inhibitors/*metabolism ; Phosphorylation ; Protein Phosphatase 1 ; RNA-Binding Proteins/metabolism/pharmacology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Synapses/*metabolism ; Thionucleotides/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-12
    Description: Lipidic cubic phases provide a continuous three-dimensional bilayer matrix that facilitates nucleation and growth of bacteriorhodopsin microcrystals. The crystals diffract x-rays isotropically to 2.0 angstroms. The structure of this light-driven proton pump was solved at a resolution of 2.5 angstroms by molecular replacement, using previous results from electron crystallographic studies as a model. The earlier structure was generally confirmed, but several differences were found, including loop conformations and side chain residues. Eight water molecules are now identified experimentally in the proton pathway. These findings reveal the constituents of the proton translocation pathway in the ground state.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pebay-Peyroula, E -- Rummel, G -- Rosenbusch, J P -- Landau, E M -- New York, N.Y. -- Science. 1997 Sep 12;277(5332):1676-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Biologie Structurale/CEA-CNRS/Universite Joseph Fourier, 41 Avenue des Martyrs, F-38027 Grenoble Cedex 1, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9287223" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteriorhodopsins/*chemistry ; Crystallization ; Crystallography, X-Ray/*methods ; Cytoplasm/chemistry ; Glycerides ; Halobacterium/chemistry ; Hydrogen Bonding ; Models, Molecular ; *Protein Conformation ; Protein Structure, Secondary ; Proton Pumps ; Protons ; Retinaldehyde/chemistry ; Schiff Bases ; Synchrotrons ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    A new class of stable head-to tail (Z-type) Langmuir Blodgett films. A second harmonic generation study (1988)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 110 (1988), S. 2672-2674 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00216a064
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  • 5
    Electronic Resource
    Electronic Resource
    Reexamination of carbodiimide as a possible affinity label for the acetylcholine receptor at the frog neuromuscular junction (1977)
    Springer
    The journal of membrane biology 35 (1977), S. 1-7 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The effects of a water-soluble carbodiimide were examined at the frog neuromuscular junction. Acetylcholine sensitivity was measured using a fluid electrode technique and intracellular recording of miniature end-plate potentials. The carbodiimide blocked synaptic sensitivity by a reversible, curare-like action. Irreversible blockade was also observed, probably due to covalent binding. The conditions of reaction and irreversibility suggest that several different residues may be attacked. The inability of cholinergic antagonists to protect the receptor from attack indicates that nonspecific sites, and not the acetylcholine binding site, are involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01869936
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  • 6
    Electronic Resource
    Electronic Resource
    Morphology of Motor Nerve Terminals subjected to Polarizing Currents (1969)
    [s.l.] : Nature Publishing Group
    Nature 221 (1969), S. 271-272 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Presynaptic polarizing currents and the ultrastructure of nerve endings. Nerve endings containing vesicles and mitochondria are shown in the upper part of each plate. The suhsynaptic region of the muscle fibre (lower part of plates) is clearly separated from the nerve ending by the synaptic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/221271a0
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  • 7
    Electronic Resource
    Electronic Resource
    THE RELATIONSHIP BETWEEN THE STATE OF NERVE-TERMINAL POLARIZATION AND LIBERATION OF ACETYLCHOLINE (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 144 (1967), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1967.tb53787.x
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  • 8
    Electronic Resource
    Electronic Resource
    Synaptic frequency demodulation (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1033-1035 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die synaptische Übertragung von Reizmustern wurde an der neuromuskularen Synapse beiRana ridibunda geprüft. Der Nerv wurde mit einer sinusoidal modulierten Frequenz gereizt und die postsynaptischen Potentiale intrazellulär abgeleitet. Daraus wird geschlossen, dass die Synapse Veränderungen in der Einsatzfrequenz überträgt, die einem “Low-pass”-Filter gleichkommt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01918654
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  • 9
    Electronic Resource
    Electronic Resource
    Vespa Larvae send out Rhythmic Hunger Signals (1972)
    [s.l.] : Nature Publishing Group
    Nature 237 (1972), S. 286-287 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 A nest of larva orientalis consisting of three interconnected combs. The openings of the cells are directed downwards. Vespa orientalis F is prevalent in countries of the Mediterranean basin, and builds its nest in cavities under the ground. The colony is found in the spring by a fertilized ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/237286a0
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  • 10
    Electronic Resource
    Electronic Resource
    Electro-mechanical noise in atrial muscle fibres of the carp (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1058-1060 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Steady membrane voltage fluctuations have been observed in atrial muscle fibres of the carp. These voltage fluctuations produce minute mechanical oscillations, as revealed by an interference contrast microscope. The steady voltage fluctuations may be related to abnormal automaticity in the heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945968
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