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  • 1
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    In:  Eos, Trans., Am. Geophys. Un., London, Army Corps of Engineers, Woodward-Clyde Consultants, vol. 80, no. 48, pp. 575, 579, 581, pp. 1062, (ISBN: 0-12-018847-3)
    Publication Date: 1999
    Keywords: Project report/description ; Volcanology ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Global Positioning System ; Gravimetry, Gravitation ; Geochemistry ; microgravity ; changes ; no ; deformation ; gas ; sulfur
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  • 2
    Publication Date: 2012-01-05
    Description: We report the three-dimensional structure of a β-catenin armadillo repeat in complex with the liver receptor homolog-1 (LRH-1) ligand binding domain at 2.8 Å resolution as the first structure of β-catenin in complex with any nuclear receptor. The surface of β-catenin that binds LRH-1 partly overlaps defined contact sites for peptide segments of β-catenin partners, including T-cell factor-4. The surface of LRH-1 that engages β-catenin is comprised of helices 1, 9, and 10 and is distinct from known interaction surfaces of LRH-1, including corepressor and coactivator binding sites. Targeted mutagenesis of amino acids forming both sides of the LRH-1/β-catenin interface reveals that they are essential for stable interactions between these proteins in solution. The LRH-1 binding site in β-catenin is also required for association with androgen receptor, providing evidence that the observed LRH-1/β-catenin interaction may be prototypic.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 3
    Publication Date: 2013-06-24
    Description: : Genome-wide expression analysis can result in large numbers of clusters of co-expressed genes. Although there are tools for ab initio discovery of transcription factor-binding sites, most do not provide a quick and easy way to study large numbers of clusters. To address this, we introduce a web tool called MEME-LaB. The tool wraps MEME (an ab initio motif finder), providing an interface for users to input multiple gene clusters, retrieve promoter sequences, run motif finding and then easily browse and condense the results, facilitating better interpretation of the results from large-scale datasets. Availability: MEME-LaB is freely accessible at: http://wsbc.warwick.ac.uk/wsbcToolsWebpage/ . Contact: p.e.brown@warwick.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 4
    Publication Date: 2018-01-20
    Description: We studied the temperature relations of wild and zoo Aldabra giant tortoises ( Aldabrachelys gigantea ) focusing on (1) the relationship between environmental temperature and tortoise activity patterns ( n  = 8 wild individuals) and (2) on tortoise body temperature fluctuations, including how their core and external body temperatures vary in relation to different environmental temperature ranges (seasons; n  = 4 wild and n  = 5 zoo individuals). In addition, we surveyed the literature to review the effect of body mass on core body temperature range in relation to environmental temperature in the Testudinidae. Diurnal activity of tortoises was bimodally distributed and influenced by environmental temperature and season. The mean air temperature at which activity is maximized was 27.9°C, with a range of 25.8–31.7°C. Furthermore, air temperature explained changes in the core body temperature better than did mass, and only during the coldest trial, did tortoises with higher mass show more stable temperatures. Our results, together with the overall Testudinidae overview, suggest that, once variation in environmental temperature has been taken into account, there is little effect of mass on the temperature stability of tortoises. Moreover, the presence of thermal inertia in an individual tortoise depends on the environmental temperatures, and we found no evidence for inertial homeothermy. Finally, patterns of core and external body temperatures in comparison with environmental temperatures suggest that Aldabra giant tortoises act as mixed conformer–regulators. Our study provides a baseline to manage the thermal environment of wild and rewilded populations of an important island ecosystem engineer species in an era of climate change. According to the patterns of body temperature in relation to environmental temperature, Aldabra giant tortoises act as conformer–regulators. In the wild, tortoises modify their daily and seasonal activity and regulate their body temperature close to 30°C. This study provides a baseline to manage the thermal environment of wild and rewilded populations of an important island ecosystem engineer species in an era of climate change.
    Electronic ISSN: 2045-7758
    Topics: Biology
    Published by Wiley
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  • 5
    Publication Date: 2016-12-08
    Description: Plants obtain soil-resident elements that support growth and metabolism from the water-flow facilitated by transpiration and active transport processes. The availability of elements in the environment interacts with the genetic capacity of organisms to modulate element uptake through plastic adaptive responses, such as homeostasis. These interactions should cause the elemental contents of plants to vary such that the effects of genetic polymorphisms will be dramatically dependent on the environment in which the plant is grown. To investigate genotype by environment interactions underlying elemental accumulation, we analyzed levels of elements in maize kernels of the Intermated B73 Mo17 (IBM) recombinant inbred population grown in 10 different environments, spanning a total of six locations and five different years. In analyses conducted separately for each environment, we identified a total of 79 quantitative trait loci (QTL) controlling seed elemental accumulation. While a set of these QTL was found in multiple environments, the majority were specific to a single environment, suggesting the presence of genetic by environment interactions. To specifically identify and quantify QTL by environment interactions (QEIs), we implemented two methods: linear modeling with environmental covariates, and QTL analysis on trait differences between growouts. With these approaches, we found several instances of QEI, indicating that elemental profiles are highly heritable, interrelated, and responsive to the environment.
    Electronic ISSN: 2160-1836
    Topics: Biology
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  • 6
    Publication Date: 2023-06-08
    Description: Pyroclastic density currents (PDCs) that escape their confining channels are among the most dangerous of volcanic hazards. These unconfined PDCs are capable of inundating inhabited areas that may be unprepared for these hazards, resulting in significant loss of life and damage to infrastructure. Unconfined PDCs can be categorized based on some of their primary dynamic characteristics (e.g., velocity, concentration, dynamic pressure, temperature), which also determine the impacts that they have on humans and infrastructure. Here, we used impact assessments following eruptions at Merapi (Indonesia) in 2010 and Fuego (Guatemala) in 2018 to better understand the dynamics of the PDCs during the eruptions. By analyzing these and similar events, we identified four main categories of unconfined PDC based on their dynamic characteristics: 1. fast overspill flows, 2. slow overspill flows, 3. high-energy surges, and 4. low-energy detached surges (LEDS). How we treat the uncertainty associated with forecasting the inundation area of these PDCs (e.g., in modelling) significantly impacts hazard planning for areas prone to volcanic eruptions. We provide an example of this using hazard modelling of lava dome collapse PDCs from several high-risk volcanoes in Southeast Asia, which show a difference in the projected impacts depending on the overspill buffer with which the PDC is modelled.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 7
    Publication Date: 2021-05-17
    Description: Campi Flegrei is an active volcanic area situated in the Campanian Plain (Italy) and dominated by a resurgent caldera. The great majority of past eruptions have been explosive, variable in magnitude, intensity, and in their vent locations. In this hazard assessment study we present a probabilistic analysis using a variety of volcanological data sets to map the background spatial probability of vent opening conditional on the occurrence of an event in the foreseeable future. The analysis focuses on the reconstruction of the location of past eruptive vents in the last 15 ka, including the distribution of faults and surface fractures as being representative of areas of crustal weakness. One of our key objectives was to incorporate some of the main sources of epistemic uncertainty about the volcanic system through a structured expert elicitation, thereby quantifying uncertainties for certain important model parameters and allowing outcomes from different expert weighting models to be evaluated. Results indicate that past vent locations are the most informative factors governing the probabilities of vent opening, followed by the locations of faults and then fractures. Our vent opening probability maps highlight the presence of a sizeable region in the central eastern part of the caldera where the likelihood of new vent opening per kilometer squared is about 6 times higher than the baseline value for the whole caldera. While these probability values have substantial uncertainties associated with them, our findings provide a rational basis for hazard mapping of the next eruption at Campi Flegrei caldera.
    Description: Published
    Description: 2309-2329
    Description: 6V. Pericolosità vulcanica e contributi alla stima del rischio
    Description: JCR Journal
    Keywords: vent opening probability maps ; expert judgment ; Campi Flegrei caldera
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 8
    Publication Date: 2021-05-17
    Description: In this study, we combine reconstructions of volcanological data sets and inputs from a structured expert judgment to produce a first long-term probability map for vent opening location for the next Plinian or sub-Plinian eruption of Somma-Vesuvio. In the past, the volcano has exhibited significant spatial variability in vent location; this can exert a significant control on where hazards materialize (particularly of pyroclastic density currents). The new vent opening probability mapping has been performed through (i) development of spatial probability density maps with Gaussian kernel functions for different data sets and (ii) weighted linear combination of these spatial density maps. The epistemic uncertainties affecting these data sets were quantified explicitly with expert judgments and implemented following a doubly stochastic approach. Various elicitation pooling metrics and subgroupings of experts and target questions were tested to evaluate the robustness of outcomes. Our findings indicate that (a) Somma-Vesuvio vent opening probabilities are distributed inside the whole caldera, with a peak corresponding to the area of the present crater, but with more than 50% probability that the next vent could open elsewhere within the caldera; (b) there is a mean probability of about 30% that the next vent will open west of the present edifice; (c) there is a mean probability of about 9.5% that the next medium-large eruption will enlarge the present Somma-Vesuvio caldera, and (d) there is a nonnegligible probability (mean value of 6–10%) that the next Plinian or sub-Plinian eruption will have its initial vent opening outside the present Somma-Vesuvio caldera.
    Description: Published
    Description: 4357 – 4376
    Description: 6V. Pericolosità vulcanica e contributi alla stima del rischio
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 9
    Publication Date: 2017-04-04
    Description: Disasters from explosive volcanic eruptions are infrequent and experience in emergency planning and mitigation for such events remains limited. The need for urgently developing more robust methods for risk assessment and decision making in volcanic crises has become increasingly apparent as world populations continue to expand in areas of active explosive volcanism. Nowhere is this more challenging than at Vesuvius, Italy, with hundreds of thousands of people living on the flanks of one of the most dangerous volcanoes in the world. We describe how a new paradigm, evidence-based volcanology, has been applied in EXPLORIS to contribute to crisis planning and management for when the volcano enters its next state of unrest, as well as in long-term land-use planning. The analytical approach we adopted enumerates and quantifies all the processes and effects of the eruptive hazards of the volcano known to influence risk, a scientific challenge that combines field data on the vulnerability of the built environment and humans in past volcanic disasters with theoretical research on the state of the volcano, and including evidence from the field on previous eruptions as well as numerical simulation modelling of eruptive processes. Formal probabilistic reasoning under uncertainty and a decision analysis approach have provided the basis for the development of an event tree for a future range of eruption types with probability paths and hypothetical casualty outcomes for risk assessment. The most likely future eruption scenarios for emergency planning were derived from the event tree and elaborated upon from the geological and historical record. Modelling the impacts in these scenarios and quantifying the consequences for the circumvesuvian area provide realistic assessments for disaster planning and for showing the potential risk–benefit of mitigation measures, the main one being timely evacuation, but include for consideration protecting buildings against dilute, low dynamic pressure surges, and temporary roof supports in the most vulnerable buildings, as well as hardening infrastructure and lifelines. This innovative work suggests that risk-based methods could have an important role in crisis management at cities on volcanoes and small volcanic islands.
    Description: Published
    Description: 454-473
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: open
    Keywords: planning ; emergency ; volcano ; eruption ; mitigation ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 10
    Publication Date: 2017-04-04
    Description: No Abstract
    Description: Published
    Description: V-IX
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: reserved
    Keywords: Rischio Vulcanico ; Exploris ; Vulcani esplosivi ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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