ISSN:
1573-8221
Keywords:
rhodopsin resynthesis
;
retina
;
hereditary retinal dystrophy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Rhodopsin resynthesis was studied in vivo in the retina and optic cup of two strains of rats with hereditary dystrophy: Campbell albino rats and Hunter rats with pigmented eyes. Wistar and MSU rats, respectively, were used as the controls. The rate of reduction of rhodopsin after its decolorization in the retina in the affected animals was shown to be much slower than in healthy animals and to decrease as the disease developed. In the period of marked morphological changes, only 50% of the decolorized pigment was reduced during 2 h of dark adaptation (the time for complete regeneration of rhodopsin in healthy rats). In Campbell and Hunter rats the breakdown and resynthesis of rhodopsin take place not only in the retina, but also in the layer of fragments of outer segments of the photoreceptors, located between cells of the pigmented epithelium and the retina.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00800113
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