ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Steroidal Cardiotonics, I. Introduction of Substituents into the Butenolide Ring of Heart GlycosidesThe introduction of halogen, alkyl, and alkoxy substituents into the lactone ring of cardenolide glycosides has been achieved via intramolecular PO-activated cyclization with 14β-hydroxy-C/D-cis-steroid aglycones and glycosides deriving from heart glycosides like digoxin, digitoxin, ouabain, evomonosid, and convallatoxol. The structure of the C-22 substituted glycosides (7, 8, 10, 13) was identified by spectroscopic methods.
Notes:
Die Einführung von Halogen-, Alkyl- und Alkoxy-Substituenten in den Lactonring von Cardenolidglykosiden gelingt durch intramolekulare PO-aktivierte Cyclisierung an 14β-Hydroxy-C/D-cis-steroid-Aglykonen und -Glykosiden vom Typ Digoxin, Digitoxin, Ouabain, Evomonosid und Convallatoxol. Die Struktur der C-22-substituierten Glykoside (7, 8, 10, 13) wurde mittels spektroskopischer Methoden gesichert.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19721051122
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