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  • 1
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    Neuronal Mechanics and Transport (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progression of neurodegenerative diseases, acute traumatic injury, and for designing novel approaches to promote neuronal regeneration following disease, stroke, or trauma. Mechanical properties and forces shape the development of the nervous system from the cellular up to the organ level. Recent advances in quantitative live cell imaging, biophysical, and nanotechnological methods such as traction force microscopy, optical tweezers, and atomic force microscopy have enabled researchers to gain better insights into how cytoskeletal dynamics and motor-driven transport, membrane-dynamics, adhesion, and substrate rigidity influence axonal elongation. Given the complexity and mechanical nature of this problem, mathematical modeling contributes significantly to our understanding of neuronal mechanics. Nonetheless, there has been limited direct interaction and discussions between experimentalists and theoreticians in this research area. The purpose of this Frontiers Research Topic is to highlight exciting and important work that is currently developing in the fields of neuronal cell biology, neuronal mechanics, intracellular transport, and mathematical modeling in the form of primary research articles, reviews, perspectives, and commentaries.
    Keywords: RC321-571 ; Q1-390 ; neuronal development ; neuronal mechanics ; Axonal elongation ; force ; Neuronal morphology ; stiffness ; glia ; Neuronal transport ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    E-BOOK
  • 2
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    Kinematic modeling of cross-sectional deformation sequences by computer simulation (1990)
    In:  J. Geophys. Res., Roma, Publicazioni dell'Istituto Nazionale di Geofisica, vol. 95, no. B2, pp. 21913-21929, pp. 2128, (ISBN: 0-12-018847-3)
    Details
    Publication Date: 1990
    Keywords: Crustal deformation (cf. Earthquake precursor: deformation or strain) ; flexural ; flow ; folding ; Geol. aspects ; JGR
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    BIBLIOGRAPHY SEISMOLOGY
  • 3
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    Global patterns of tectonic stress (1989)
    In:  Nature, Stockholm, 3-4, vol. 341, no. B6, pp. 291-298, pp. L17317, (ISSN: 1340-4202)
    Details
    Publication Date: 1989
    Keywords: Stress ; Review article ; Stress measurements ; Mueller ; Muller ; Suarez ; Udias ; Bluemling ; Blumling
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    BIBLIOGRAPHY SEISMOLOGY
  • 4
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    Orientational data on the state of stress in northeastern Mexico as inferred from stress-induced borehole elongations (1987)
    In:  J. Geophys. Res., Washington, D.C., AGU, vol. 92, no. 4, pp. 2617-2626, pp. B05402, (ISSN: 1340-4202)
    Details
    Publication Date: 1987
    Keywords: Stress ; Borehole breakouts ; JGR
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    BIBLIOGRAPHY SEISMOLOGY
  • 5
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    Orientational data on the state of stress in northeastern Mexico as inferred from stress-induced borehole elongation (1987)
    In:  Journal of Geophysical Research, Washington, D.C., AGU, vol. 92, no. B3, pp. 2617-2626, pp. B05402, (ISSN: 1340-4202)
    Details
    Publication Date: 1987
    Keywords: Stress ; Borehole breakouts ; Borehole Televiewer ; JGR
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    BIBLIOGRAPHY SEISMOLOGY
  • 6
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    Memory and relatedness of transcriptional activity in mammalian cell lineages (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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    PAPER CURRENT
  • 7
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    Nitrogen yield advantage from grass-legume mixtures is robust over a wide range of legume proportions and environmental conditions (2015)
    Wiley
    Details
    Publication Date: 2015-01-29
    Description: Current challenges to global food security require sustainable intensification of agriculture through initiatives that include more efficient use of nitrogen (N), increased protein self-sufficiency through home-grown crops, and reduced N losses to the environment. Such challenges were addressed in a continental-scale field experiment conducted over three years, in which the amount of total nitrogen yield (N tot ) and the gain of N yield in mixtures as compared to grass monocultures (N gainmix ) was quantified from four-species grass-legume stands with greatly varying legume proportions. Stands consisted of monocultures and mixtures of two N 2 fixing legumes and two non-fixing grasses.The amount of N tot of mixtures was significantly greater ( P ≤ 0.05) than that of grass monocultures at the majority of evaluated sites in all three years. N tot and thus N gainmix increased with increasing legume proportion up to one third of legumes. With higher legume percentages, N tot and N gainmix did not continue to increase. Thus, across sites and years, mixtures with one third proportion of legumes attained ~95% of the maximum N tot acquired by any stand and had 57% higher N tot than grass monocultures.Realized legume proportion in stands and the relative N gain in mixture (N gainmix /N tot in mixture) were most severely impaired by minimum site temperature ( R = 0.70, P = 0.003 for legume proportion; R = 0.64, P = 0.010 for N gainmix /N tot in mixture). Nevertheless, the relative N gain in mixture was not correlated to site productivity ( P = 0.500), suggesting that, within climatic restrictions, balanced grass-legume mixtures can benefit from comparable relative gains in N yield across largely differing productivity levels.We conclude that the use of grass-legume mixtures can substantially contribute to resource-efficient agricultural grassland systems over a wide range of productivity levels, implying important savings in N fertilizers and thus greenhouse gas emissions and a considerable potential for climate change mitigation. This article is protected by copyright. All rights reserved.
    Print ISSN: 1354-1013
    Electronic ISSN: 1365-2486
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Published by Wiley
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  • 8
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    DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: a systematic review (2016)
    BioMed Central
    Details
    Publication Date: 2016-01-27
    Description: Increasing evidence suggests the involvement of epigenetic processes in the development of schizophrenia and bipolar disorder, and recent reviews have focused on findings in post-mortem brain tissue. A systema...
    Electronic ISSN: 1471-2156
    Topics: Biology
    Published by BioMed Central
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  • 9
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    Control of early viral and bacterial distribution and disease by natural antibodies (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-11
    Description: Natural antibodies are often dismissed from immunological analysis as "background," but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or with Listeria monocytogenes, viral or bacterial titers in peripheral organs, including the kidney and brain, were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary lymphoid organs were 10 to 100 times lower than in antibody-competent mice. Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen-trapping in secondary lymphoid organs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ochsenbein, A F -- Fehr, T -- Lutz, C -- Suter, M -- Brombacher, F -- Hengartner, H -- Zinkernagel, R M -- New York, N.Y. -- Science. 1999 Dec 10;286(5447):2156-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10591647" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Bacterial/blood/immunology ; Antibodies, Viral/blood/immunology ; Bacterial Infections/*immunology/microbiology ; Germ-Free Life ; *Immunity, Innate ; Immunoglobulin M/blood/*immunology ; Kidney/microbiology/virology ; Listeria monocytogenes/immunology/physiology ; Listeriosis/immunology ; Lymphocytic choriomeningitis virus/immunology/physiology ; Lymphoid Tissue/immunology/microbiology/virology ; Mice ; Mice, Inbred C57BL ; Neutralization Tests ; Rhabdoviridae Infections/immunology/virology ; Specific Pathogen-Free Organisms ; Spleen/microbiology/virology ; Vaccinia virus/immunology/physiology ; Vesicular stomatitis Indiana virus/immunology/physiology ; Virus Diseases/*immunology/virology ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Mammalian genes are transcribed with widely different bursting kinetics (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-03-19
    Description: In prokaryotes and eukaryotes, most genes appear to be transcribed during short periods called transcriptional bursts, interspersed by silent intervals. We describe how such bursts generate gene-specific temporal patterns of messenger RNA (mRNA) synthesis in mammalian cells. To monitor transcription at high temporal resolution, we established various gene trap cell lines and transgenic cell lines expressing a short-lived luciferase protein from an unstable mRNA, and recorded bioluminescence in real time in single cells. Mathematical modeling identified gene-specific on- and off-switching rates in transcriptional activity and mean numbers of mRNAs produced during the bursts. Transcriptional kinetics were markedly altered by cis-regulatory DNA elements. Our analysis demonstrated that bursting kinetics are highly gene-specific, reflecting refractory periods during which genes stay inactive for a certain time before switching on again.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suter, David M -- Molina, Nacho -- Gatfield, David -- Schneider, Kim -- Schibler, Ueli -- Naef, Felix -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):472-4. doi: 10.1126/science.1198817. Epub 2011 Mar 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Sciences III, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21415320" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Animals ; Cells, Cultured ; Chromatin/physiology ; Circadian Rhythm/genetics ; Down-Regulation ; *Gene Expression ; Histones/metabolism ; Kinetics ; Luminescent Measurements ; Mice ; Models, Genetic ; NIH 3T3 Cells ; Promoter Regions, Genetic ; Protein Biosynthesis ; RNA, Messenger/genetics/metabolism ; Stochastic Processes ; *Transcription, Genetic ; Transcriptional Activation ; Transgenes ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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